Dr Dilys Freeman

  • Senior Lecturer (Institute of Cardiovascular and Medical Sciences)
  • Associate (School of Medicine, Dentistry and Nursing)

telephone: 01413302299
email: Dilys.Freeman@glasgow.ac.uk

Biography

After studying Biochemistry at the University of Edinburgh, Dr Dilys Freeman undertook her PhD in industry at Glaxo Group Research in Middlesex. Postdoctoral positions in Glasgow and the University of Texas Southwestern Medical Center at Dallas were followed by her first academic appointment in Biological Science at the University of Durham. Dilys joined the University of Glasgow in 1999. Dr Freeman's early research was in the field of cardiovascular disease in particular lipid and lipoprotein metabolism. She studied cholesteryl ester transfer protein and its role in high density lipoprotein metabolism as well as the genetic regulation of plasma high density lipoprotein and low density lipoprotein levels. Dilys has been involved in the analysis of the West of Scotland Coronary Prevention Study (WOSCOPS), in particular the influence of inflammation, statins and genetics on the aetiology of type 2 diabetes. Her current research is in the field of metabolism in diabetes and also in pregnancy. 


Research interests

Member: Metabolic Disease & Diabetes Research

My current research predominantly focuses on metabolism in pregnancy and its vascular complications such as preeclampsia, gestational diabetes mellitus and growth restriction. The focus is on lipid and carbohydrate metabolism and inflammation in obese pregnancy and the role of vascular function, the adipocyte and ectopic fat in the development of adverse pregnancy outcome. The metabolic cross-talk between mother and baby, its regulation by the placenta and long term disease implications for the offspring are also of interest.


Research on type 2 diabetes involves exploring the links between adipose tissue expandability and ectopic fat accumulation. I am involved in studies comparing how adipose tissue from Europeans and South Asians adapts to weight gain and weight loss and in studies looking at how muscle stores triglyceride in insulin resistant states.


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Vaso-protective properties of maternal high density lipoprotein (HDL) in metabolic complications of pregnancy
    NHS Greater Glasgow and Clyde Endowment Funds
    2018 - 2019
     
  • Role of alternative pathway of triglyceride synthesis in determining insulin sensitivity in muscle of individuals at risk of type 2 diabetes
    Diabetes UK
    2016 - 2019
     
  • IL-33 as an Immune Regulator in Pregnancy
    Tenovus Scotland
    2014 - 2015
     
  • EMIF
    European Commission
    2013 - 2017
     
  • Early pregnancy mobilisation of fatty acids
    The Carnegie Trust for the Universities of Scotland
    2010 - 2011
     
  • Maternal lipotoxic response in obese pregnancy
    Wellbeing of Women
    2010 - 2012
     
  • The intrauterine environment and differences in adiposity and insulin resistance between South Asian and European populations
    British Heart Foundation
    2009 - 2011
     
  • Early pregnancy metabolic and inflammatory changes and their relationship to successful pregnancy
    Wellbeing of Women
    2007 - 2010
     
  • Risk factors for the development of incident thrombotic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Chest Heart and Stroke Scotland
    2005 - 2006
     
  • An investigation of the role of the chemokine receptor D6 in placental dysfunction
    Scottish Hospital Endowments Research Trust
    2005 - 2007
     
  • Adipocyte lipolysis as a candidate pathway in the pathogenesis of pre-eclampsia
    British Heart Foundation
    2004 - 2008
     
  • Maternal and fetal dyslipidaemia in polycystic ovarian syndrome pregnancy
    The Future Forum
    2004 - 2005
     
  • Longitudinal assessment of vascular function throughout pregnancy and the puerperium - relationship of maternal body fat distribution to...
    British Medical Association
    2003 - 2006
     
  • Lipocortin 1 - modulation of molecular mechanisms of inflammation in atherosclerosis
    British Heart Foundation
    2003 - 2005
     
  • Does low birth weight pregnancy signal markedly increased maternal cardiovascular risk
    Chest Heart and Stroke Scotland
    2003 - 2004
     
  • Is there a link between inflammation and insulin resistance in pre-eclampsia?
    Scottish Executive Health Department
    2003 - 2004
     

Teaching

Programme Director MSc Diabetes

Women's and Children's Health Specialist Course Co-Ordinator, Intercalated BSc.


Additional information

Editorial Board

  • 2014 - ongoing: Pediatric Obesity - Associate Editor
  • 2008 - ongoing: Clinical Science - Editorial Board and Associate Editor
  • 2000 - 2007: Atherosclerosis - Associate Editor

Invited International Presentations

  • 2014: Association for the Study of Obesity (ASO) - Organising committee and keynote speaker
  • 2013: International Association for the Study of Obesity (IASO) - Organising committee and keynote speaker
  • 2012: HDLnet COST action BM0904 Meeting - Invited speaker
  • 2011: New Zealand Maternal Fetal Medicine Network - Keynote speaker
  • 2011: American Diabetes Association - Keynote speaker
  • 2011: American Diabetes Association - Keynote speaker
  • 2011: Australian Diabetes in Pregnancy Society (ADIPS) - Keynote speaker
  • 2010: International Association of the Diabetes and Pregnancy Study Groups (IADPSG) - Keynote speaker
  • 2008: International Society for the Study of Hypertension in Pregnancy (ISSHP) - Keynote speaker

Professional Learned Society

  • 2014 - 2015: UKCO 2015 - Organising Committee
  • 2014 - ongoing: Yorkhill Children's Charity - Steering Committee
  • 2014 - 2015: International Association for the Study of Obesity - Organising Committee
  • 2013 - ongoing: Association for the Study of Obesity - Treasurer
  • 2013 - ongoing: University of Wollongong, Australia - Visiting Principal Fellow
  • 2012 - ongoing: NHSGGC - Member of the NHSGGC Research Endowments Committee
  • 2011 - ongoing: BM0904 - Management committee member (BM0904) EU COST action
  • 2008 - ongoing: University of Wollongong, Australia - Visiting Senior Fellow
  • 2007 - 2011: European Lipoprotein Club - Treasurer

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 69.

2018

Chavan-Gautam, P., Rani, A. and Freeman, D. J. (2018) Distribution of fatty acids and lipids during pregnancy. In: Makowski, G. S. (ed.) Advances in Clinical Chemistry. Elsevier, pp. 209-239. (doi:10.1016/bs.acc.2017.12.006)

Onyiaodike, C. C. et al. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8(1), 1216. (doi:10.1038/s41598-018-19500-0)

2017

Jayabalan, N. et al. (2017) Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes. Frontiers in Endocrinology, 8, 239. (doi:10.3389/fendo.2017.00239)

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F. and Freeman, D.J. (2017) Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester. Thrombosis Research, 157, pp. 49-54. (doi:10.1016/j.thromres.2017.06.027) (PMID:28692840)

Gao, X., Salomon, C. and Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, 202. (doi:10.3389/fendo.2017.00202)

Huda, S. S., Jordan, F., Bray, J., Love, G., Payne, R., Sattar, N. and Freeman, D. J. (2017) Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancy. Clinical Science, 131(13), pp. 1529-1540. (doi:10.1042/CS20160832) (PMID:28566469)

Meyer, B. J. and Freeman, D. J. (2017) Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure. Fats of Life,

Small, H. Y., Akehurst, C., Sharafetdinova, L., McBride, M. W., McClure, J. D., Robinson, S. W., Carty, D. M., Freeman, D. J. and Delles, C. (2017) HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia. Physiological Genomics, 49(3), pp. 193-200. (doi:10.1152/physiolgenomics.00106.2016) (PMID:28130428) (PMCID:PMC5374453)

Freeman, D. J. and Meyer, B. J. (2017) Brain food for babies. Biochemist, 39(1), pp. 26-29.

2016

Brown, S. H.J., Eather, S. R., Freeman, D. J., Meyer, B. J. and Mitchell, T. W. (2016) A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage. PLoS ONE, 11(9), e0163972. (doi:10.1371/journal.pone.0163972) (PMID:27685997) (PMCID:PMC5042456)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B. , Sattar, N. , Lyall, H., Nelson, S. M. and Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101(4), pp. 1745-1753. (doi:10.1210/jc.2015-3089) (PMID:26895389)

2015

Akehurst, C. et al. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33(10), pp. 2068-2074. (doi:10.1097/HJH.0000000000000656) (PMID:26213997) (PMCID:PMC4570688)

Escola-Gil, J.C., Julve, J., Griffin, B.A., Freeman, D.J. and Blanco-Vaca, F. (2015) HDL and lifestyle interventions. In: von Eckardstein, A. and Kardassis, D. (eds.) High Density Lipoproteins: From Biological Understanding to Clinical Exploitation. Series: Handbook of experimental pharmacology (224). Springer Open: Cham, pp. 569-592. ISBN 9783319096650 (doi:10.1007/978-3-319-09665-0_18)

2014

Lawlor, D. A., West, J., Fairley, L., Nelson, S. M. , Bhopal, R. S., Tuffnell, D., Freeman, D. J., Wright, J., Whitelaw, D. C. and Sattar, N. (2014) Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother–offspring pairs: findings from a prospective pregnancy cohort. Diabetologia, 57(12), pp. 2492-2500. (doi:10.1007/s00125-014-3386-6)

Huda, S. S., Forrest, R., Paterson, N., Jordan, F., Sattar, N. and Freeman, D. J. (2014) In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy. Hypertension, 63(5), pp. 1094-1101. (doi:10.1161/​HYPERTENSIONAHA.113.01824) (PMID:24591340)

2013

McKenna, L., Huda, S., Freeman, D. and Jarvie, E. (2013) How to assess and manage hypertension during and after pregnancy. Clinical Practice, 10(4), pp. 455-470. (doi:10.2217/CPR.13.34)

Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J. and Freeman, D.J. (2013) Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98(2), pp. 643-652. (doi:10.1210/jc.2012-3481)

Hodson, L., Neville, M., Chong, M.F.-F., Rogers, I., Huda, S.S., Freeman, D.J., Frayn, K.N. and Fielding, B.A. (2013) Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), pp. 1128-1133. (doi:10.1016/j.numecd.2012.11.003)

2012

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D., Freeman, D.J., Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi:10.1111/1471-0528.12016)

Carty, D.M., Anderson, L.A., Freeman, D.J., Welsh, P.I. , Brennand, J.E., Dominiczak, A.F. and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30(5), pp. 954-959. (doi:10.1097/HJH.0b013e328352573b)

Bernini, F. et al. (2012) European lipoprotein club: report of the 34th ELC annual conference, Tutzing, 5–8 September 2011. Atherosclerosis, 221(1), pp. 287-293. (doi:10.1016/j.atherosclerosis.2011.12.002)

Mackay, V.A. et al. (2012) Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency. Hypertension, 60(4), pp. 1078-1085. (doi:10.1161/HYPERTENSIONAHA.112.197897)

Sattar, N. and Freeman, D.J. (2012) Potential mechanisms contributing to gestational diabetes and pre-eclampsia in the obese woman. In: Gillman, M.W. and Poston, L. (eds.) Maternal Obesity. Series: Cambridge medicine. Cambridge University Press: Cambridge, UK, pp. 45-55. ISBN 978107003965 (doi:10.1017/CBO9780511782466)

Sattar, N. and Freeman, D.J. (2012) Potential mechanisms contributing to gestational diabetes and preeclampsia in the obese woman. In: Gillman, M.W. and Poston, L. (eds.) Maternal Obesity. Cambridge University Press. ISBN 9781107003965

2011

Bernini, F., Fisher, R., Freeman, D.J., Groen, A., Kalopissis, A., Malle, E., Mulder, M., Niemeier, A., Parini, P. and Hansen, A.T. (2011) Report of the 33rd Annual Conference of the European Lipoprotein Club, Tutzing, 6–9 September 2010. Atherosclerosis, 215(1), pp. 249-255. (doi:10.1016/j.atherosclerosis.2010.12.002)

Freeman, D. J. et al. (2011) Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). BMC Geriatrics, 11, 8. (doi:10.1186/1471-2318-11-8) (PMID:21342490) (PMCID:PMC3053238)

2010

Sattar, N. et al. (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet, 375(9716), pp. 735-742. (doi:10.1016/S0140-6736(09)61965-6)

Fisher, R. et al. (2010) European Lipoprotein Club: Report of the 32nd ELC Annual Conference, Tutzing, 7–10 September 2009. Atherosclerosis, 210(2), pp. 680-686. (doi:10.1016/j.atherosclerosis.2009.12.038)

Freeman, D.J. (2010) Effects of maternal obesity on fetal growth and body composition: implications for programming and future health. Seminars in Fetal and Neonatal Medicine, 15(2), pp. 113-118. (doi:10.1016/j.siny.2009.09.001 Univ Glasgow, Western Infirm, Fac Med, Glasgow G11 6NT, Lanark, Scotland.)

Freeman, D.J. and Sattar, N. (2010) The effect of pregnancy on energy metabolism, body composition and endothelial function. In: Tsatsoulis, A., Wyckoff, J. and Brown, F.M. (eds.) Diabetes in Women. Series: Contemporary diabetes. Humana Press Inc., pp. 207-222. ISBN 9781603272506 (doi:10.1007/978-1-60327-250-6_11)

Jarvie, E., Hauguel‑de‑Mouzon, S., Nelson, S.M. , Sattar, N. , Catalano, P.M. and Freeman, D.J. (2010) Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. Clinical Science, 119(3), pp. 123-129. (doi:10.1042/CS20090640)

Madigan, J. et al. (2010) Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients. Journal of Immunology, 184(6), pp. 3202-3212. (doi:10.4049/jimmunol.0902118)

Nelson, S. M. , Stewart, F., Fleming, R. and Freeman, D. J. (2010) Longitudinal assessment of antimullerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin. Fertility and Sterility, 93(4), pp. 1356-1358. (doi:10.1016/j.fertnstert.2009.07.1676)

Sofat, R. et al. (2010) Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation, 121(1), pp. 52-62. (doi:10.1161/CIRCULATIONAHA.109.865444)

2009

Bernini, F. et al. (2009) European Lipoprotein Club: Report of the 31st ELC Annual Conference, Tutzing, 8–11 September 20. Atherosclerosis, 205(1), pp. 41-47. (doi:10.1016/j.atherosclerosis.2008.12.003)

Huda, S.S., Freeman, D.J. and Nelson, S.M. (2009) Short and long term strategies for the management of hypertensive disorders of pregnancy. Expert Review of Cardiovascular Therapy, 7(12), pp. 1581-1594. (doi:10.1586/erc.09.147)

Huda, S., Sattar, N. and Freeman, D. (2009) Lipoprotein metabolism and vascular complications in pregnancy. Clinical Lipidology, 4(1), pp. 91-102.

Kanagalingam, M.G., Nelson, S. , Freeman, D., Ferrell, W.R., Cherry, L.M., Lowe, G.D.O., Greer, I.A. and Sattar, N.A. (2009) Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring. Atherosclerosis, 205(1), pp. 244-250. (doi:10.1016/j.atherosclerosis.2008.10.006)

Nelson, S. , Freeman, D., Sattar, N. and Lindsay, R. (2009) Erythrocytosis in offspring of mothers with Type 1 diabetes-are factors other than insulin critical determinants? Diabetic Medicine, 26(9), pp. 887-892. (doi:10.1111/j.1464-5491.2009.02797.x)

Sattar, N. et al. (2009) Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. Diabetologia, 52(2), pp. 235-239.

2008

Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi:10.1136/ard.2007.086652)

Sattar, N. et al. (2008) Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet, 371(9628), pp. 1927-1935. (doi:10.1016/S0140-6736(08)60602-9)

Freeman, D., Tham, K., Brown, E., Rumley, A., Lowe, G. and Greer, I. (2008) Placental corticotrophin-releasing hormone RNA and microparticles in maternal plasma are not measures of placental shedding of debris: reply to a rebuttal. Journal of Thrombosis and Haemostasis, 6(10), pp. 1838-1839.

Freeman, D., Tham, K., Brown, E., Rumley, A., Lowe, G. and Greer, I. (2008) Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia. Journal of Thrombosis and Haemostasis, 6(3), pp. 421-427. (doi:10.1111/j.1538-7836.2007.02882.x)

Hofker, M. et al. (2008) European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3–6 Septem. Atherosclerosis, 197(1), pp. 471-479. (doi:10.1016/j.atherosclerosis.2007.12.022)

Meyer, B. and Freeman, D. (2008) Role of omega-3 polyunsaturated fatty acids in pregnancy: need for increasing awareness among women. Agro Food Industry Hi-Tech, 19(4), pp. 17-19.

Nelson, S. , Freeman, D.J., Sattar, N. and Lindsay, R.S. (2008) Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes. Diabetes Care, 31(6), pp. 1123-1125. (doi:10.2337/dc07-2195)

2007

Stewart, F.M., Freeman, D.J., Ramsay, J.E., Greer, I.A., Caslake, M. and Ferrell, W.R. (2007) Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. Journal of Clinical Endocrinology and Metabolism, 92(3), pp. 969-975. (doi:10.1210/jc.2006-2083)

Freeman, D. (2007) Genetic factors in vascular disease. In: Greer, I.A., Ginsberg, J. and Forbes, C.D. (eds.) Women's Vascular Health. Hodder Arnold: London, pp. 52-60. ISBN 100340809973

Nelson, S. , Freeman, D., Lindsay, R.S. and Sattar, N. (2007) Preeclampsia and screening for cardiovascular disease. BMJ Rapid Response,

Nelson, S.M. , Freeman, D.J., Sattar, N. , Johnstone, F.D. and Lindsay, R.S. (2007) IGF-1 and leptin associate with fetal HDL cholesterol at birth: Examination in offspring of mothers with type 1 diabetes. Diabetes, 56, pp. 2705-2709. (doi:10.2337/db07-0585)

Nelson, S. , Sattar, N. , Freeman, D., Walker, J. and Lindsay, R. (2007) Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetes. Diabetes, 56, pp. 2697-2704. (doi:10.2337/db07-0662)

Stewart, F., Rodie, V., Ramsay, J., Greer, I., Freeman, D. and Meyer, B. (2007) Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partum. Lipids, 42, pp. 335-344. (doi:10.1007/s11745-006-3005-5)

2006

Freeman, D. (2006) Update on gestational hypertension. Women's Health, 2(5), pp. 695-698.

2005

Boekholdt, S. et al. (2005) Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment - Individual patient meta-analysis of 13,677 subjects. Circulation, 111, pp. 278-287. (doi:10.1161/01.CIR.0000153341.46271.40)

Rodie, V., Young, A., Jordan, F., Sattar, N. , Greer, I. and Freeman, D. (2005) Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction. Journal of the Society For Gynecologic Investigation, 12, pp. 320-329. (doi:10.1016/j.jsgi.2005.03.004)

2004

Freeman, D., McManus, F., Brown, E., Cherry, L., Norrie, J., Ramsay, J., Clark, P., Walker, I., Sattar, N. and Greer, I. (2004) Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension, 44, pp. 708-714. (doi:10.1161/01.HYP.0000143849.67254.ca)

Rodie, V., Caslake, M., Stewart, F., Sattar, N. , Ramsay, J., Greer, I. and Freeman, D. (2004) Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis, 176, pp. 181-187. (doi:10.1016/j.atherosclerosis.2004.04.026)

Rodie, V., Freeman, D., Sattar, N. and Greer, I. (2004) Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? Atherosclerosis, 175, pp. 189-202. (doi:10.1016/j.atherosclerosis.2004.01.038)

Shepherd, J. et al. (2004) CHD and diabetes reversing the trend. Doctor, Supple, pp. 1-8.

2003

Clark, P., Freeman, D., Streja, E., Sattar, N. , Walker, I. and Greer, I. (2003) The G-to-T point mutation in codon 34 of the factor XIII gene and the risk of pre-eclampsia. Blood Coagulation and Fibrinolysis, 14, pp. 155-157. (doi:10.1097/01.mbc.0000046189.72384.5a)

Freeman, D., Samani, N., Wilson, V., McMahon, A., Braund, P., Cheng, S., Caslake, M., Packard, C. and Gaffney, D. (2003) A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. European Heart Journal, 24, pp. 1833-1842. (doi:10.1016/j.ehj.2003.07.001)

Shepherd, A. et al. (2003) Stroke prevention in primary care. Doctor, Supple, pp. 1-8.

Shepherd, J. et al. (2003) Obesity, metabolic syndrome and cardiovascular risk. Doctor, Supple, pp. 1-8.

2002

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D. S. J.,, Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600. (doi:10.2337/diabetes.51.5.1596)

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D.S., Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600.

Shepherd, J.S. et al. (2002) Pragmatic coronary prevention, identifying patients at high risk of coronary heart disease. British Journal of Cardiology, 9(4), S1-S15.

2001

Freeman, D. et al. (2001) Pravastatin and the development of diabetes mellitus - Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation, 103(3), pp. 357-362.

This list was generated on Sun May 27 18:31:04 2018 BST.
Number of items: 69.

Articles

Onyiaodike, C. C. et al. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8(1), 1216. (doi:10.1038/s41598-018-19500-0)

Jayabalan, N. et al. (2017) Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes. Frontiers in Endocrinology, 8, 239. (doi:10.3389/fendo.2017.00239)

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F. and Freeman, D.J. (2017) Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester. Thrombosis Research, 157, pp. 49-54. (doi:10.1016/j.thromres.2017.06.027) (PMID:28692840)

Gao, X., Salomon, C. and Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, 202. (doi:10.3389/fendo.2017.00202)

Huda, S. S., Jordan, F., Bray, J., Love, G., Payne, R., Sattar, N. and Freeman, D. J. (2017) Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancy. Clinical Science, 131(13), pp. 1529-1540. (doi:10.1042/CS20160832) (PMID:28566469)

Meyer, B. J. and Freeman, D. J. (2017) Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure. Fats of Life,

Small, H. Y., Akehurst, C., Sharafetdinova, L., McBride, M. W., McClure, J. D., Robinson, S. W., Carty, D. M., Freeman, D. J. and Delles, C. (2017) HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia. Physiological Genomics, 49(3), pp. 193-200. (doi:10.1152/physiolgenomics.00106.2016) (PMID:28130428) (PMCID:PMC5374453)

Freeman, D. J. and Meyer, B. J. (2017) Brain food for babies. Biochemist, 39(1), pp. 26-29.

Brown, S. H.J., Eather, S. R., Freeman, D. J., Meyer, B. J. and Mitchell, T. W. (2016) A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage. PLoS ONE, 11(9), e0163972. (doi:10.1371/journal.pone.0163972) (PMID:27685997) (PMCID:PMC5042456)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B. , Sattar, N. , Lyall, H., Nelson, S. M. and Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101(4), pp. 1745-1753. (doi:10.1210/jc.2015-3089) (PMID:26895389)

Akehurst, C. et al. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33(10), pp. 2068-2074. (doi:10.1097/HJH.0000000000000656) (PMID:26213997) (PMCID:PMC4570688)

Lawlor, D. A., West, J., Fairley, L., Nelson, S. M. , Bhopal, R. S., Tuffnell, D., Freeman, D. J., Wright, J., Whitelaw, D. C. and Sattar, N. (2014) Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother–offspring pairs: findings from a prospective pregnancy cohort. Diabetologia, 57(12), pp. 2492-2500. (doi:10.1007/s00125-014-3386-6)

Huda, S. S., Forrest, R., Paterson, N., Jordan, F., Sattar, N. and Freeman, D. J. (2014) In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy. Hypertension, 63(5), pp. 1094-1101. (doi:10.1161/​HYPERTENSIONAHA.113.01824) (PMID:24591340)

McKenna, L., Huda, S., Freeman, D. and Jarvie, E. (2013) How to assess and manage hypertension during and after pregnancy. Clinical Practice, 10(4), pp. 455-470. (doi:10.2217/CPR.13.34)

Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J. and Freeman, D.J. (2013) Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98(2), pp. 643-652. (doi:10.1210/jc.2012-3481)

Hodson, L., Neville, M., Chong, M.F.-F., Rogers, I., Huda, S.S., Freeman, D.J., Frayn, K.N. and Fielding, B.A. (2013) Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), pp. 1128-1133. (doi:10.1016/j.numecd.2012.11.003)

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D., Freeman, D.J., Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi:10.1111/1471-0528.12016)

Carty, D.M., Anderson, L.A., Freeman, D.J., Welsh, P.I. , Brennand, J.E., Dominiczak, A.F. and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30(5), pp. 954-959. (doi:10.1097/HJH.0b013e328352573b)

Bernini, F. et al. (2012) European lipoprotein club: report of the 34th ELC annual conference, Tutzing, 5–8 September 2011. Atherosclerosis, 221(1), pp. 287-293. (doi:10.1016/j.atherosclerosis.2011.12.002)

Mackay, V.A. et al. (2012) Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency. Hypertension, 60(4), pp. 1078-1085. (doi:10.1161/HYPERTENSIONAHA.112.197897)

Bernini, F., Fisher, R., Freeman, D.J., Groen, A., Kalopissis, A., Malle, E., Mulder, M., Niemeier, A., Parini, P. and Hansen, A.T. (2011) Report of the 33rd Annual Conference of the European Lipoprotein Club, Tutzing, 6–9 September 2010. Atherosclerosis, 215(1), pp. 249-255. (doi:10.1016/j.atherosclerosis.2010.12.002)

Freeman, D. J. et al. (2011) Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). BMC Geriatrics, 11, 8. (doi:10.1186/1471-2318-11-8) (PMID:21342490) (PMCID:PMC3053238)

Sattar, N. et al. (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet, 375(9716), pp. 735-742. (doi:10.1016/S0140-6736(09)61965-6)

Fisher, R. et al. (2010) European Lipoprotein Club: Report of the 32nd ELC Annual Conference, Tutzing, 7–10 September 2009. Atherosclerosis, 210(2), pp. 680-686. (doi:10.1016/j.atherosclerosis.2009.12.038)

Freeman, D.J. (2010) Effects of maternal obesity on fetal growth and body composition: implications for programming and future health. Seminars in Fetal and Neonatal Medicine, 15(2), pp. 113-118. (doi:10.1016/j.siny.2009.09.001 Univ Glasgow, Western Infirm, Fac Med, Glasgow G11 6NT, Lanark, Scotland.)

Jarvie, E., Hauguel‑de‑Mouzon, S., Nelson, S.M. , Sattar, N. , Catalano, P.M. and Freeman, D.J. (2010) Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. Clinical Science, 119(3), pp. 123-129. (doi:10.1042/CS20090640)

Madigan, J. et al. (2010) Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients. Journal of Immunology, 184(6), pp. 3202-3212. (doi:10.4049/jimmunol.0902118)

Nelson, S. M. , Stewart, F., Fleming, R. and Freeman, D. J. (2010) Longitudinal assessment of antimullerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin. Fertility and Sterility, 93(4), pp. 1356-1358. (doi:10.1016/j.fertnstert.2009.07.1676)

Sofat, R. et al. (2010) Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation, 121(1), pp. 52-62. (doi:10.1161/CIRCULATIONAHA.109.865444)

Bernini, F. et al. (2009) European Lipoprotein Club: Report of the 31st ELC Annual Conference, Tutzing, 8–11 September 20. Atherosclerosis, 205(1), pp. 41-47. (doi:10.1016/j.atherosclerosis.2008.12.003)

Huda, S.S., Freeman, D.J. and Nelson, S.M. (2009) Short and long term strategies for the management of hypertensive disorders of pregnancy. Expert Review of Cardiovascular Therapy, 7(12), pp. 1581-1594. (doi:10.1586/erc.09.147)

Huda, S., Sattar, N. and Freeman, D. (2009) Lipoprotein metabolism and vascular complications in pregnancy. Clinical Lipidology, 4(1), pp. 91-102.

Kanagalingam, M.G., Nelson, S. , Freeman, D., Ferrell, W.R., Cherry, L.M., Lowe, G.D.O., Greer, I.A. and Sattar, N.A. (2009) Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring. Atherosclerosis, 205(1), pp. 244-250. (doi:10.1016/j.atherosclerosis.2008.10.006)

Nelson, S. , Freeman, D., Sattar, N. and Lindsay, R. (2009) Erythrocytosis in offspring of mothers with Type 1 diabetes-are factors other than insulin critical determinants? Diabetic Medicine, 26(9), pp. 887-892. (doi:10.1111/j.1464-5491.2009.02797.x)

Sattar, N. et al. (2009) Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. Diabetologia, 52(2), pp. 235-239.

Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi:10.1136/ard.2007.086652)

Sattar, N. et al. (2008) Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet, 371(9628), pp. 1927-1935. (doi:10.1016/S0140-6736(08)60602-9)

Freeman, D., Tham, K., Brown, E., Rumley, A., Lowe, G. and Greer, I. (2008) Placental corticotrophin-releasing hormone RNA and microparticles in maternal plasma are not measures of placental shedding of debris: reply to a rebuttal. Journal of Thrombosis and Haemostasis, 6(10), pp. 1838-1839.

Freeman, D., Tham, K., Brown, E., Rumley, A., Lowe, G. and Greer, I. (2008) Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia. Journal of Thrombosis and Haemostasis, 6(3), pp. 421-427. (doi:10.1111/j.1538-7836.2007.02882.x)

Hofker, M. et al. (2008) European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3–6 Septem. Atherosclerosis, 197(1), pp. 471-479. (doi:10.1016/j.atherosclerosis.2007.12.022)

Meyer, B. and Freeman, D. (2008) Role of omega-3 polyunsaturated fatty acids in pregnancy: need for increasing awareness among women. Agro Food Industry Hi-Tech, 19(4), pp. 17-19.

Nelson, S. , Freeman, D.J., Sattar, N. and Lindsay, R.S. (2008) Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes. Diabetes Care, 31(6), pp. 1123-1125. (doi:10.2337/dc07-2195)

Stewart, F.M., Freeman, D.J., Ramsay, J.E., Greer, I.A., Caslake, M. and Ferrell, W.R. (2007) Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. Journal of Clinical Endocrinology and Metabolism, 92(3), pp. 969-975. (doi:10.1210/jc.2006-2083)

Nelson, S. , Freeman, D., Lindsay, R.S. and Sattar, N. (2007) Preeclampsia and screening for cardiovascular disease. BMJ Rapid Response,

Nelson, S.M. , Freeman, D.J., Sattar, N. , Johnstone, F.D. and Lindsay, R.S. (2007) IGF-1 and leptin associate with fetal HDL cholesterol at birth: Examination in offspring of mothers with type 1 diabetes. Diabetes, 56, pp. 2705-2709. (doi:10.2337/db07-0585)

Nelson, S. , Sattar, N. , Freeman, D., Walker, J. and Lindsay, R. (2007) Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetes. Diabetes, 56, pp. 2697-2704. (doi:10.2337/db07-0662)

Stewart, F., Rodie, V., Ramsay, J., Greer, I., Freeman, D. and Meyer, B. (2007) Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partum. Lipids, 42, pp. 335-344. (doi:10.1007/s11745-006-3005-5)

Freeman, D. (2006) Update on gestational hypertension. Women's Health, 2(5), pp. 695-698.

Boekholdt, S. et al. (2005) Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment - Individual patient meta-analysis of 13,677 subjects. Circulation, 111, pp. 278-287. (doi:10.1161/01.CIR.0000153341.46271.40)

Rodie, V., Young, A., Jordan, F., Sattar, N. , Greer, I. and Freeman, D. (2005) Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction. Journal of the Society For Gynecologic Investigation, 12, pp. 320-329. (doi:10.1016/j.jsgi.2005.03.004)

Freeman, D., McManus, F., Brown, E., Cherry, L., Norrie, J., Ramsay, J., Clark, P., Walker, I., Sattar, N. and Greer, I. (2004) Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension, 44, pp. 708-714. (doi:10.1161/01.HYP.0000143849.67254.ca)

Rodie, V., Caslake, M., Stewart, F., Sattar, N. , Ramsay, J., Greer, I. and Freeman, D. (2004) Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis, 176, pp. 181-187. (doi:10.1016/j.atherosclerosis.2004.04.026)

Rodie, V., Freeman, D., Sattar, N. and Greer, I. (2004) Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? Atherosclerosis, 175, pp. 189-202. (doi:10.1016/j.atherosclerosis.2004.01.038)

Shepherd, J. et al. (2004) CHD and diabetes reversing the trend. Doctor, Supple, pp. 1-8.

Clark, P., Freeman, D., Streja, E., Sattar, N. , Walker, I. and Greer, I. (2003) The G-to-T point mutation in codon 34 of the factor XIII gene and the risk of pre-eclampsia. Blood Coagulation and Fibrinolysis, 14, pp. 155-157. (doi:10.1097/01.mbc.0000046189.72384.5a)

Freeman, D., Samani, N., Wilson, V., McMahon, A., Braund, P., Cheng, S., Caslake, M., Packard, C. and Gaffney, D. (2003) A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. European Heart Journal, 24, pp. 1833-1842. (doi:10.1016/j.ehj.2003.07.001)

Shepherd, A. et al. (2003) Stroke prevention in primary care. Doctor, Supple, pp. 1-8.

Shepherd, J. et al. (2003) Obesity, metabolic syndrome and cardiovascular risk. Doctor, Supple, pp. 1-8.

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D. S. J.,, Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600. (doi:10.2337/diabetes.51.5.1596)

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D.S., Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600.

Shepherd, J.S. et al. (2002) Pragmatic coronary prevention, identifying patients at high risk of coronary heart disease. British Journal of Cardiology, 9(4), S1-S15.

Freeman, D. et al. (2001) Pravastatin and the development of diabetes mellitus - Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation, 103(3), pp. 357-362.

Book Sections

Chavan-Gautam, P., Rani, A. and Freeman, D. J. (2018) Distribution of fatty acids and lipids during pregnancy. In: Makowski, G. S. (ed.) Advances in Clinical Chemistry. Elsevier, pp. 209-239. (doi:10.1016/bs.acc.2017.12.006)

Escola-Gil, J.C., Julve, J., Griffin, B.A., Freeman, D.J. and Blanco-Vaca, F. (2015) HDL and lifestyle interventions. In: von Eckardstein, A. and Kardassis, D. (eds.) High Density Lipoproteins: From Biological Understanding to Clinical Exploitation. Series: Handbook of experimental pharmacology (224). Springer Open: Cham, pp. 569-592. ISBN 9783319096650 (doi:10.1007/978-3-319-09665-0_18)

Sattar, N. and Freeman, D.J. (2012) Potential mechanisms contributing to gestational diabetes and pre-eclampsia in the obese woman. In: Gillman, M.W. and Poston, L. (eds.) Maternal Obesity. Series: Cambridge medicine. Cambridge University Press: Cambridge, UK, pp. 45-55. ISBN 978107003965 (doi:10.1017/CBO9780511782466)

Sattar, N. and Freeman, D.J. (2012) Potential mechanisms contributing to gestational diabetes and preeclampsia in the obese woman. In: Gillman, M.W. and Poston, L. (eds.) Maternal Obesity. Cambridge University Press. ISBN 9781107003965

Freeman, D.J. and Sattar, N. (2010) The effect of pregnancy on energy metabolism, body composition and endothelial function. In: Tsatsoulis, A., Wyckoff, J. and Brown, F.M. (eds.) Diabetes in Women. Series: Contemporary diabetes. Humana Press Inc., pp. 207-222. ISBN 9781603272506 (doi:10.1007/978-1-60327-250-6_11)

Freeman, D. (2007) Genetic factors in vascular disease. In: Greer, I.A., Ginsberg, J. and Forbes, C.D. (eds.) Women's Vascular Health. Hodder Arnold: London, pp. 52-60. ISBN 100340809973

This list was generated on Sun May 27 18:31:04 2018 BST.