Development of a surface enhanced Raman scattering (SERS) sensor for point of care therapeutic drug monitoring in canine epilepsy
Supervisors:
Duncan Graham, Pure and Applied Chemistry, University of Strathclyde
Stacey Laing, Pure and Applied Chemistry, University of Strathclyde
William Peveler, School of Chemistry, University of Glasgow
Mark McLaughlin, School of Biodiversity, One Health & Veterinary Medicine,University of Glasgow
Catherine Stalin, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow
Summary:
This multidisciplinary PhD project aims to develop a point-of-care (POC) sensor for therapeutic drug monitoring (TDM) in canine epilepsy. Epilepsy is the most common neurological disorder in dogs and, since the condition is incurable, treatment aims to control the symptoms. TDM is essential in dogs receiving epilepsy treatment to ensure they are receiving the correct dose of drugs to reduce the frequency and intensity of seizures, while minimizing side effects. Current TDM is by needle stick blood tests when treatment begins and when seizures occur; however, a less distressing test would allow more frequent testing and closer monitoring while maintaining the comfort of the patients. Surface enhanced Raman scattering (SERS) is a highly sensitive and specific detection technique that is widely applicable for POC testing.
The aim of this project is the fabrication and testing of a SERS-based POC sensor for the detection of anti-epileptic drugs in canine saliva. Working with a variety of scientists and veterinarian clinicians, the PhD student on this project will be trained in a wide range of scientific techniques, while developing key transferable skills and potentially solving a real-world problem in animal health.