Dr William Peveler
- Lord Kelvin Adam Smith Research Fellow (School of Chemistry)
telephone: 0141 330 2000 x.0911
Available Positions - 1 PhD and 2 PDRAs
15 month PDRA position to start c. June 2020
We are looking for a synthetic chemist to join the group. You will design, synthesise and test new luminescent molecular architectures for the sensing of liver fibrosis, to create a sensor array for the disease. The final sensor will then be validated in collaboration with clinicians in London, Edinburgh and Glasgow. There will be opportunities to develop analytical, statistical and programming skills during the project.
Deaths from liver disease, in contrast to cancer and heart disease, have increased over the last 30 years, at an estimated £9bn annual cost to the NHS. Liver disease severity, treatment and survival are heavily impacted by the amount of liver scarring (fibrosis) caused by the disease. To improve detection and treatment of this liver scarring, we are working with the UK’s leading clinicians to develop new blood tests that can identify fibrosis at an early stage, without recourse to painful and invasive liver biopsy.
2 year PDRA position to start May 2020
Sepsis is a life-threatening condition caused by the body's response to an infection and is responsible for one in five deaths worldwide. Finding rapidly what pathogens are causing the underlying infection is key to patient's treatment, and yet current available techniques require days before identification.
We are looking for a researcher to join the SEPsis project; designing and synthesising new biomolecules to functionalise engineered magnetic nanoparticles. The materials are inspired by the immune system, to efficiently capture pathogens from clinical samples for rapid identification using existing and emerging techniques (e.g. MALDI-TOF, sequencing). The project is a collaboration with Dr Melanie Jimenez (James Watt School of Engineering, University of Glasgow), Prof. Carl Goodyear (Institute of Infection, Immunity and Inflammation, University of Glasgow), Dr Michael Murphy (Glasgow Royal Infirmary) and Dr Kenneth Baillie (Roslin Institute, University of Edinburgh).
PhD to start October 2020
Applications are invited for a fully funded 3.5-year PhD position, expected to commence on 1st October 2020. This PhD project will seek to improve the speed, sensitivity and accuracy of a sensor array for detecting biomarkers of liver fibrosis, leading to a better blood test for the condition.
The project will involve the synthesis of luminescent molecular architectures, testing the molecules created against clinical samples, and analysing the data with statistical pattern recognition tools. This research intersects synthetic and analytical chemistry, statistics and clinical medicine and will be carried out in collaboration with engineers at Glasgow University and clinicians in Edinburgh and London.
The ideal candidate will hold (or expect to hold) a 1st or upper 2nd class MSc/MChem/BSc or equivalent, be a creative and enthusiastic experimentalist, and have excellent communication and organisational skills. Some experience of multi-step synthetic organic/materials chemistry would be advantageous.
In the Bio-Nano-Sensing lab, our research focuses on the nanoscale interface between materials chemistry and biology. By synthesising new nanomaterials and functional molecules and by attempting to control nano-surface chemistry, we create new tools, techniques and sensors for use in biomedicine, industry and defence. Luminescent and plasmonic nanomaterials are of particular interest, and current projects focus on gold nanoparticles, quantum dots and fluorescent polymer nanoparticles.
With collaborators in Chemistry (Farnaby), the James Watt School of Engineering (Clark, Jimenez), Strathclyde University (Ward), LMU Munich (Cortés) and the University of British Columbia (Algar), my group are currently synthesising and characterising new luminescent nanomaterials for improved near-patient blood testing; building cross-reactive sensing arrays for biomedical and industrial sensing; and tailoring nanoparticle surface chemistry to sense and measure bacteria.
- Fluorescent nanoparticle assemblies for protein and nucleic acid sensing
- Colorimetric and luminescent sensing arrays for detecting liver disease and fraud
- Lanthanide-containing polymer nanoparticles for multimodal imaging
- Nano-surface chemistry for bacterial siderophore detection and bacteria binding
- Novel labels for super-resolution imaging and optical sensing
I am a Lord Kelvin Adam Smith Fellow working in the School of Chemistry. After work with Dr Martin Grossel and Professor Harry Anderson FRS at the University of Oxford for my MChem, I moved to London to undertake a PhD in Chemistry at UCL (Professor Ivan Parkin), as part of the SECReT CDT, for which I was awarded the Ramsay Medal.
I then won an EPSRC Doctoral Prize Fellowship and Royal Society International Exchange Grant to undertake 2 years of postdoctoral work with Professors Claire Carmalt and William Rosenberg (UCL/Royal Free Hospital) and Professor Vincent Rotello (UMass Amherst), and subsequently a Killam Postdoctoral Research Fellowship at the University of British Columbia with Professor Russ Algar. I joined the University of Glasgow in 2018 to begin my independent career.
Small molecule and nanoparticle synthesis and modification; Luminescent spectroscopy; Chemical and materials characterisation; Array-based sensing and chemometrics.
The Academy of Medical Sciences Springboard Grant "Fluorescent Sensor Arrays for Serum-Based Liver Fibrosis Detection." 2020-2022. £100k
Chief Scientist Office Research Grant "Rapid new methods for sepsis diagnosis in hospitals using microsystems." 2020-2022. £300k Co-I with Dr Melanie Jimenez, University of Glasgow
Royal Society Research Grant “Switchable nanoparticle assemblies for photonic sensing.” 2020-2021. £20k
SULSA Technology Seed Fund “Siderophore fingerprinting on low-cost electrochemical sensors.” 2019-2020. £6k Co-I with Dr Andrew Ward, University of Strathclyde
University of Glasgow/EPSRC Early Career Capital Award “A multifunctional, multi-user spectrometer” 2019. £40k
University of Glasgow LKAS Fellowship “Materials for Point-of-Care Liver Disease Diagnosis.” 2018-2022. £165k
Killam Foundation Postdoctoral Fellowship “Hand-Held, Point-of-Care Biomarker Assays Enabled by Quantum Dots.” 2017-2018. £50k
Royal Society International Exchange “Array-based sensing for disease detection.” 2016-2017. £12k
EPSRC Doctoral Prize Fellowship “Functional nanomaterials for small molecule sensing and disease detection.” 2015-2017. £111k
Katie McGuire 2019 –
"Nanoparticle surface chemistry for novel sensing applications"
ENG2087 (part) – Blood and Biomedical Engineering
Demonstrating 1st and 3rd year Organic/Synthetic Chemistry
Organic Chemistry tutorials (2nd year)