Dr Mark McLaughlin

  • Senior Lecturer (Veterinary Science & Education )

telephone: 01413305716or6278
email: Mark.McLaughlin@glasgow.ac.uk

Veterinary Biosciences, Jarrett Building, Glasgow G61 1QH

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-5317-2090

Research interests

My research is focused on the molecular basis of neurological disorders and how ‘omics’ technology can be applied, in a broader sense, to topics related to veterinary medicine including biomarker discovery.

Working with the veterinary clinical neurology team integrates my interest in neurodegenerative disorders with a translational aim.   Our group has been investigating the nature of the pathology associated with canine degenerative myelopathy (DM) which is now regarded as a valid model of human motor neuron disease. We are currently exploring the cellular mechanisms involved in the disease process using a combination of in vitro cell culture systems and the analysis of postmortem material. Our objective is to use significant discoveries on the disease process, together with identification of potential biomarkers, to assist in developing strategies with therapeutic potential which may also translate to human conditions.

My research interests in protein dynamics extends into both large and small animal veterinary medicine, primarily through my collaborations with Profs David Eckersall and Nicholas Jonsson. I was a member of the COST-Action in Farm Animal Proteomics and recently a co-PI on the European Union’s Horizon 2020 research and innovation programme H2020-MSCA- ITN-2017- EJD: Marie Skłodowska-Curie ITN, European Joint Doctorate in Molecular Animal Nutrition (MANNA). This has been a highly successful programme involving partners Fabrizio Ceciliani (University of Milan), Armand Sanchez Bonastre (University Barcelona) Helga Sauerwein (University of Bonn), Vladimir Mrljak (University of Zagreb) & Mangesh Bhide (University of Kosice) with 11 PhD students.

My research continues to combine fundamental biochemical and imaging methodology with powerful ‘omics’ technology to understand the molecular bases of known and newly emerging disorders affecting both animal and human.

Research groups

Publications

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Number of items: 61.

2024

O'Reilly, E. L. et al. (2024) Biomarker and proteome analysis of milk from dairy cows with clinical mastitis: determining the effect of different bacterial pathogens on the response to infection. Research in Veterinary Science, 172, 105240. (doi: 10.1016/j.rvsc.2024.105240) (PMID:38608347)

2023

Huang, Y., Jonsson, N. N. , McLaughlin, M. , Burchmore, R. , Johnson, P. C.D. , Jones, R. , McGill, S., Brady, N., Weidt, S. and Eckersall, D. (2023) Quantitative TMT-based proteomics revealing host, dietary and microbial proteins in bovine faeces including barley serpin Z4, a prominent component in the head of beer. Journal of Proteomics, 285, 104941. (doi: 10.1016/j.jprot.2023.104941) (PMID:37285906)

Peinado-Izaguerri, J. , Zarzuela, E., McLaughlin, M. , Small, A. C., Riva, F., McKeegan, D. E.F. , Bain, M. , Muñoz, J., Bhide, M. and Preston, T. (2023) A novel dynamic proteomics approach for the measurement of broiler chicken protein fractional synthesis rate. Rapid Communications in Mass Spectrometry, 37(10), e9497. (doi: 10.1002/rcm.9497) (PMID:36851885)

Nguyen, T. X. et al. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part I: serum proteomes. Journal of Proteomics, 270, 104740. (doi: 10.1016/j.jprot.2022.104740) (PMID:36191802)

Nguyen, T. X., Agazzo, A., McGill, S., Weidt, S., Han, Q. H., Gelemanović, A., McLaughlin, M. , Savoini, G., Eckersall, P. D. and Burchmore, R. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part II: ileum proteomes. Journal of Proteomics, 270, 104739. (doi: 10.1016/j.jprot.2022.104739) (PMID:36174954)

2022

Nguyen, T. X. et al. (2022) Abundance of plasma proteins in response to divergent ratios of dietary ω6:ω3 fatty acids in gestating and lactating sows using a quantitative proteomics approach. Journal of Proteomics, 260, 104562. (doi: 10.1016/j.jprot.2022.104562) (PMID:35314360)

2021

McGonigal, R. , Barrie, J. A., Yao, D., Black, L. E. , McLaughlin, M. and Willison, H. J. (2021) Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice. Journal of Neurochemistry, 158(2), pp. 217-232. (doi: 10.1111/jnc.15365) (PMID:33864399)

Almeida, A. M. et al. (2021) Domestic animal proteomics in the 21st century: A global retrospective and viewpoint analysis. Journal of Proteomics, 241, 104220. (doi: 10.1016/j.jprot.2021.104220) (PMID:33838350)

Baka, R. et al. (2021) Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic seizures. Journal of Proteomics, 231, 103997. (doi: 10.1016/j.jprot.2020.103997) (PMID:33011347)

Horvatić, A. et al. (2021) Multi-omics approach to elucidate cerebrospinal fluid changes in dogs with intervertebral disc herniation. International Journal of Molecular Sciences, 22(21), 11678. (doi: 10.3390/ijms222111678)

2020

Pesko, B. K., Weidt, S., McLaughlin, M. , Wescott, D. J., Torrance, H., Burgess, K. and Burchmore, R. (2020) Post-mortomics: the potential of untargeted metabolomics to highlight markers for time since death. OMICS: A Journal of Integrative Biology, 24(11), pp. 649-659. (doi: 10.1089/omi.2020.0084) (PMID:33095683)

McNaught, K. A., Morris, J. S. and McLaughlin, M. (2020) Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma. Veterinary and Comparative Oncology, 18(3), pp. 292-302. (doi: 10.1111/vco.12550) (PMID:31654603)

Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)

2019

Qi, Y., Montague, P., Loney, C. , Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD 1 protein associated with canine degenerative myelopathy. European Journal of Neuroscience, 50(12), pp. 3896-3905. (doi: 10.1111/ejn.14526) (PMID:31336405)

Hough, D. , Robinson, J.E. , Bellingham, M. , Fleming, L.M., McLaughlin, M. , Jama, K., Haraldsen, I.R.H., Solbakk, A.K. and Evans, N.P. (2019) Peripubertal GnRH and testosterone co-treatment leads to increased familiarity preferences in male sheep. Psychoneuroendocrinology, 108, pp. 70-77. (doi: 10.1016/j.psyneuen.2019.06.008) (PMID:31229635) (PMCID:PMC6712355)

Gutierrez-Quintana, R. , McLaughlin, M. , Grau Roma, L., Hammond, G., Gray, A. and Lowrie, M. (2019) Spongiform leucoencephalomyelopathy in border terriers: clinical, electrophysiological and imaging features. Veterinary Record, 185, 375. (doi: 10.1136/vr.105240) (PMID:31346136)

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)

McGonigal, R. , Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)

2018

Wyse, C.A., Zhang, X., McLaughlin, M. , Biello, S.M. , Hough, D., Bellingham, M. , Curtis, A.M., Robinson, J.E. and Evans, N.P. (2018) Circadian rhythms of melatonin and behaviour in juvenile sheep in field conditions: effects of photoperiod, environment and weaning. Physiology and Behavior, 194, pp. 362-370. (doi: 10.1016/j.physbeh.2018.06.001) (PMID:29894760)

2017

Hough, D. , Bellingham, M. , Haraldsen, J.R., McLaughlin, M. , Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep. Psychoneuroendocrinology, 77, pp. 1-8. (doi: 10.1016/j.psyneuen.2016.11.029) (PMID:27987429) (PMCID:PMC5333793)

Hough, D. , Bellingham, M. , Haraldsen, I.R.H., McLaughlin, M. , Rennie, M., Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep. Psychoneuroendocrinology, 75, pp. 173-182. (doi: 10.1016/j.psyneuen.2016.10.016) (PMID:27837697) (PMCID:PMC5140006)

2016

Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi: 10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)

2015

Braceland, M., McLoughlin, M.F., Tinsley, J., Wallace, C., Cockerill, D., McLaughlin, M. and Eckersall, P.D. (2015) Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. Journal of Fish Diseases, 28(9), pp. 821-831. (doi: 10.1111/jfd.12296) (PMID:25168106)

Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Wilson, D., Herzyk, P. , Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi: 10.1017/S2040470015000023)

2014

Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Herzyk, P. , Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi: 10.3920/978-90-8686-810-0)

Shafie, I. N.F., McLaughlin, M. , Burchmore, R. , Lim, M. A. A., Montague, P., Johnston, P. E.J. , Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi: 10.1007/s12192-013-0457-4)

Almeida, A.M. et al. (2014) Animal board invited review: advances in proteomics for animal and food sciences. Animal, 9(1), pp. 1-17. (doi: 10.1017/S1751731114002602) (PMID:25359324) (PMCID:PMC4301196)

Albalat, A., Husi, H., Siwy, J., Nally, J. E., McLaughlin, M. , Eckersall, P. D. and Mullen, W. (2014) Capillary electrophoresis interfaced with a mass spectrometer (CE-MS): technical considerations and applicability for biomarker studies in animals. Current Protein and Peptide Science, 15(1), pp. 23-35. (doi: 10.2174/1389203715666140221123920) (PMID:24555889)

Ghazali, M., Koh-Tan, H. H., McLaughlin, M. , Montague, P., Jonsson, N. N. and Eckersall, P. (2014) Alkaline phosphatase in nasal secretion of cattle: biochemical and molecular characterisation. BMC Veterinary Research, 10(1), 204. (doi: 10.1186/s12917-014-0204-9) (PMID:25927913) (PMCID:PMC4173004)

McQueen, J., Reimer, M.M., Holland, P.R., Manso, Y., McLaughlin, M. , Fowler, J.H. and Horsburgh, K. (2014) Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. PLoS ONE, 9(2), e87227. (doi: 10.1371/journal.pone.0087227) (PMID:24498301) (PMCID:PMC3911923)

2013

Shafie, I.N.F., Anderson, T.J. , Penderis, J., Eckersall, P.D. and McLaughlin, M. (2013) A protocol for the management of canine cerebrospinal fluid for the proteomic assessment of putative biomarkers. Veterinary Journal, 197(3), pp. 836-841. (doi: 10.1016/j.tvjl.2013.05.039)

2011

Eckersall, P. D. and McLaughlin, M. (2011) Proteomics in animal health and disease. In: Eckersall, P. D. and Whitfield, P. D. (eds.) Methods in Animal Proteomics. Wiley-Blackwell, pp. 243-318. ISBN 9780813817910 (doi: 10.1002/9780470960660.ch10)

2010

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)

Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)

Evans, R.D., Weston, D.A., McLaughlin, M. and Brown, A.M. (2010) A non-linear regression analysis method for quantitative resolution of the stimulus-evoked compound action potential from rodent optic nerve. Journal of Neuroscience Methods, 188(1), pp. 174-178. (doi: 10.1016/j.jneumeth.20%U 10.02.004)

2009

Lowrie, M., Penderis, J., McLaughlin, M. , Eckersall, P.D. and Anderson, T.J. (2009) Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). Journal of Veterinary Internal Medicine, 23(4), pp. 862-870. (doi: 10.1111/j.1939-1676.2009.0337.x)

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi: 10.1002/jnr.21867)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)

Lowrie, M., Penderis, J., Eckersall, P.D., McLaughlin, M. , Mellor, D. and Anderson, T.J. (2009) The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Veterinary Journal, 182(1), pp. 125-130. (doi: 10.1016/j.tvjl.2008.05.001)

2008

Thomson, C.E., McCulloch, M., Sorenson, A., Barnett, S.C. , Seed, B.V., Griffiths, I.R. and McLaughlin, M. (2008) Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. European Journal of Neuroscience, 28(8), pp. 1518-1535. (doi: 10.1111/j.1460-9568.2008.06415.x)

2007

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi: 10.1007/s11064-006-9122-y)

2006

Wyse, C.A., Nixon, C., McLaughlin, M. , Dowell, F.J. and Philbey, A.W. (2006) Evidence for the expression and enzymatic activity of haem oxygenase-1 in the lungs of horses. Veterinary Record, 158(23), pp. 795-798. (doi: 10.1136/vr.158.23.795)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi: 10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J., Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi: 10.1002/glia.20325)

2005

Montague, P., McCallion, A., Barrie, J., Edgar, J., McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi: 10.1002/glia.20155)

2004

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi: 10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J., McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi: 10.1007/s00401-003-0808-9)

2003

Al-Saktawi, K., McLaughlin, M., Klugmann, M., Schneider, A., Barrie, J., McCulloch, M., Montague, P., Kirkham, D., Nave, K. and Griffiths, I. (2003) Genetic background determines phenotypic severity of the Plp rumpshaker mutation. Journal of Neuroscience Research, 72, pp. 12-24. (doi: 10.1002/jnr.10561)

2002

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi: 10.1002/glia.10103) (PMID:12203392)

McLaughlin, M., Hunter, D., Thomson, C., Yool, D. , Kirkham, D., Freer, A. and Griffiths, I. (2002) Evidence for possible interactions between PLP and DM20 within the myelin sheath. Glia, 39(1), pp. 31-36. (doi: 10.1002/glia.10091) (PMID:12112373)

2001

Yool, D.A. , Klugmann, M., McLaughlin, M., Vouyiouklis, D.A., Dimou, L., Barrie, J.A., McCulloch, M.C., Nave, K.-A. and Griffiths, I.R. (2001) Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons. Journal of Neuroscience Research, 63(2), pp. 151-164. (doi: 10.1002/1097-4547(20010115)63:2<151::AID-JNR1007>3.0.CO;2-Y) (PMID:11169625)

O'Neill, C., Anderton, B., Georgopoulou, N., McLaughlin, M. , McFarlane, I. and Breen, K. C. (2001) The role of post-translational modification in ϐ-amyloid precursor protein processing. Biochemical Society Symposia, 67, pp. 23-36. (doi: 10.1042/bss0670023) (PMID:11447837)

2000

Shinomura, T., del Río, E., Breen, K.C., Downes, C.P. and McLaughlin, M. (2000) Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes. British Journal of Pharmacology, 131(5), pp. 1011-1018. (doi: 10.1038/sj.bjp.0703651) (PMID:11053224) (PMCID:PMC1572410)

1999

McLaughlin, M. and Breen, K.C. (1999) Protein kinase C activation potentiates the rapid secretion of the amyloid precursor protein from rat cortical synaptosomes. Journal of Neurochemistry, 72(1), pp. 273-81. (doi: 10.1046/j.1471-4159.1999.0720273.x) (PMID:9886079)

Cousin, M. A., McLaughlin, M. and Nicholls, D. G. (1999) Protein kinase C modulates field-evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin-sensitive K+channel. European Journal of Neuroscience, 11(1), pp. 101-109. (doi: 10.1046/j.1460-9568.1999.00412.x) (PMID:9987015)

Del Río, E., McLaughlin, M. , Downes, C.P. and Nicholls, D.G. (1999) Differential coupling of G-protein-linked receptors to Ca2+mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture. European Journal of Neuroscience, 11(9), pp. 3015-3022. (doi: 10.1046/j.1460-9568.1999.00714.x) (PMID:10510166)

McLaughlin, M. , Inglis, F.M., Ross, B.M., Breen, K.C. and McCulloch, J. (1999) Modest cholinergic deafferentation fails to alter hippocampal G-proteins. Neurochemistry International, 35(1), pp. 59-64. (doi: 10.1016/S0197-0186(99)00033-9) (PMID:10403430)

1996

McLaughlin, M. , Brunton, V., Morrison, V., Rae, A., Cooke, T. and Bartlett, J. (1996) Growth inhibition of gastric cancer cell lines by the tyrphostin RG13022 and its effects on intracellular signalling. International Journal of Oncology, 8(3), pp. 589-596. (doi: 10.3892/ijo.8.3.589) (PMID:21544401)

1993

Ross, B. M., McLaughlin, M. , Roberts, M., Milligan, G. , McCulloch, J. and Knowler, J. T. (1993) Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease. Brain Research, 622(1-2), pp. 35-42. (doi: 10.1016/0006-8993(93)90798-R) (PMID:8242380)

1991

McLaughlin, M. , Ross, B. M., Milligan, G. , McCulloch, J. and Knowler, J. T. (1991) Robustness of G proteins in Alzheimer's disease: an immunoblot study. Journal of Neurochemistry, 57(1), pp. 9-14. (doi: 10.1111/j.1471-4159.1991.tb02092.x) (PMID:1904911)

This list was generated on Sun May 19 02:19:31 2024 BST.
Number of items: 61.

Articles

O'Reilly, E. L. et al. (2024) Biomarker and proteome analysis of milk from dairy cows with clinical mastitis: determining the effect of different bacterial pathogens on the response to infection. Research in Veterinary Science, 172, 105240. (doi: 10.1016/j.rvsc.2024.105240) (PMID:38608347)

Huang, Y., Jonsson, N. N. , McLaughlin, M. , Burchmore, R. , Johnson, P. C.D. , Jones, R. , McGill, S., Brady, N., Weidt, S. and Eckersall, D. (2023) Quantitative TMT-based proteomics revealing host, dietary and microbial proteins in bovine faeces including barley serpin Z4, a prominent component in the head of beer. Journal of Proteomics, 285, 104941. (doi: 10.1016/j.jprot.2023.104941) (PMID:37285906)

Peinado-Izaguerri, J. , Zarzuela, E., McLaughlin, M. , Small, A. C., Riva, F., McKeegan, D. E.F. , Bain, M. , Muñoz, J., Bhide, M. and Preston, T. (2023) A novel dynamic proteomics approach for the measurement of broiler chicken protein fractional synthesis rate. Rapid Communications in Mass Spectrometry, 37(10), e9497. (doi: 10.1002/rcm.9497) (PMID:36851885)

Nguyen, T. X. et al. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part I: serum proteomes. Journal of Proteomics, 270, 104740. (doi: 10.1016/j.jprot.2022.104740) (PMID:36191802)

Nguyen, T. X., Agazzo, A., McGill, S., Weidt, S., Han, Q. H., Gelemanović, A., McLaughlin, M. , Savoini, G., Eckersall, P. D. and Burchmore, R. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part II: ileum proteomes. Journal of Proteomics, 270, 104739. (doi: 10.1016/j.jprot.2022.104739) (PMID:36174954)

Nguyen, T. X. et al. (2022) Abundance of plasma proteins in response to divergent ratios of dietary ω6:ω3 fatty acids in gestating and lactating sows using a quantitative proteomics approach. Journal of Proteomics, 260, 104562. (doi: 10.1016/j.jprot.2022.104562) (PMID:35314360)

McGonigal, R. , Barrie, J. A., Yao, D., Black, L. E. , McLaughlin, M. and Willison, H. J. (2021) Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice. Journal of Neurochemistry, 158(2), pp. 217-232. (doi: 10.1111/jnc.15365) (PMID:33864399)

Almeida, A. M. et al. (2021) Domestic animal proteomics in the 21st century: A global retrospective and viewpoint analysis. Journal of Proteomics, 241, 104220. (doi: 10.1016/j.jprot.2021.104220) (PMID:33838350)

Baka, R. et al. (2021) Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic seizures. Journal of Proteomics, 231, 103997. (doi: 10.1016/j.jprot.2020.103997) (PMID:33011347)

Horvatić, A. et al. (2021) Multi-omics approach to elucidate cerebrospinal fluid changes in dogs with intervertebral disc herniation. International Journal of Molecular Sciences, 22(21), 11678. (doi: 10.3390/ijms222111678)

Pesko, B. K., Weidt, S., McLaughlin, M. , Wescott, D. J., Torrance, H., Burgess, K. and Burchmore, R. (2020) Post-mortomics: the potential of untargeted metabolomics to highlight markers for time since death. OMICS: A Journal of Integrative Biology, 24(11), pp. 649-659. (doi: 10.1089/omi.2020.0084) (PMID:33095683)

McNaught, K. A., Morris, J. S. and McLaughlin, M. (2020) Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma. Veterinary and Comparative Oncology, 18(3), pp. 292-302. (doi: 10.1111/vco.12550) (PMID:31654603)

Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)

Qi, Y., Montague, P., Loney, C. , Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD 1 protein associated with canine degenerative myelopathy. European Journal of Neuroscience, 50(12), pp. 3896-3905. (doi: 10.1111/ejn.14526) (PMID:31336405)

Hough, D. , Robinson, J.E. , Bellingham, M. , Fleming, L.M., McLaughlin, M. , Jama, K., Haraldsen, I.R.H., Solbakk, A.K. and Evans, N.P. (2019) Peripubertal GnRH and testosterone co-treatment leads to increased familiarity preferences in male sheep. Psychoneuroendocrinology, 108, pp. 70-77. (doi: 10.1016/j.psyneuen.2019.06.008) (PMID:31229635) (PMCID:PMC6712355)

Gutierrez-Quintana, R. , McLaughlin, M. , Grau Roma, L., Hammond, G., Gray, A. and Lowrie, M. (2019) Spongiform leucoencephalomyelopathy in border terriers: clinical, electrophysiological and imaging features. Veterinary Record, 185, 375. (doi: 10.1136/vr.105240) (PMID:31346136)

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)

McGonigal, R. , Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)

Wyse, C.A., Zhang, X., McLaughlin, M. , Biello, S.M. , Hough, D., Bellingham, M. , Curtis, A.M., Robinson, J.E. and Evans, N.P. (2018) Circadian rhythms of melatonin and behaviour in juvenile sheep in field conditions: effects of photoperiod, environment and weaning. Physiology and Behavior, 194, pp. 362-370. (doi: 10.1016/j.physbeh.2018.06.001) (PMID:29894760)

Hough, D. , Bellingham, M. , Haraldsen, J.R., McLaughlin, M. , Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep. Psychoneuroendocrinology, 77, pp. 1-8. (doi: 10.1016/j.psyneuen.2016.11.029) (PMID:27987429) (PMCID:PMC5333793)

Hough, D. , Bellingham, M. , Haraldsen, I.R.H., McLaughlin, M. , Rennie, M., Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep. Psychoneuroendocrinology, 75, pp. 173-182. (doi: 10.1016/j.psyneuen.2016.10.016) (PMID:27837697) (PMCID:PMC5140006)

Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi: 10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)

Braceland, M., McLoughlin, M.F., Tinsley, J., Wallace, C., Cockerill, D., McLaughlin, M. and Eckersall, P.D. (2015) Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. Journal of Fish Diseases, 28(9), pp. 821-831. (doi: 10.1111/jfd.12296) (PMID:25168106)

Shafie, I. N.F., McLaughlin, M. , Burchmore, R. , Lim, M. A. A., Montague, P., Johnston, P. E.J. , Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi: 10.1007/s12192-013-0457-4)

Almeida, A.M. et al. (2014) Animal board invited review: advances in proteomics for animal and food sciences. Animal, 9(1), pp. 1-17. (doi: 10.1017/S1751731114002602) (PMID:25359324) (PMCID:PMC4301196)

Albalat, A., Husi, H., Siwy, J., Nally, J. E., McLaughlin, M. , Eckersall, P. D. and Mullen, W. (2014) Capillary electrophoresis interfaced with a mass spectrometer (CE-MS): technical considerations and applicability for biomarker studies in animals. Current Protein and Peptide Science, 15(1), pp. 23-35. (doi: 10.2174/1389203715666140221123920) (PMID:24555889)

Ghazali, M., Koh-Tan, H. H., McLaughlin, M. , Montague, P., Jonsson, N. N. and Eckersall, P. (2014) Alkaline phosphatase in nasal secretion of cattle: biochemical and molecular characterisation. BMC Veterinary Research, 10(1), 204. (doi: 10.1186/s12917-014-0204-9) (PMID:25927913) (PMCID:PMC4173004)

McQueen, J., Reimer, M.M., Holland, P.R., Manso, Y., McLaughlin, M. , Fowler, J.H. and Horsburgh, K. (2014) Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. PLoS ONE, 9(2), e87227. (doi: 10.1371/journal.pone.0087227) (PMID:24498301) (PMCID:PMC3911923)

Shafie, I.N.F., Anderson, T.J. , Penderis, J., Eckersall, P.D. and McLaughlin, M. (2013) A protocol for the management of canine cerebrospinal fluid for the proteomic assessment of putative biomarkers. Veterinary Journal, 197(3), pp. 836-841. (doi: 10.1016/j.tvjl.2013.05.039)

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)

Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)

Evans, R.D., Weston, D.A., McLaughlin, M. and Brown, A.M. (2010) A non-linear regression analysis method for quantitative resolution of the stimulus-evoked compound action potential from rodent optic nerve. Journal of Neuroscience Methods, 188(1), pp. 174-178. (doi: 10.1016/j.jneumeth.20%U 10.02.004)

Lowrie, M., Penderis, J., McLaughlin, M. , Eckersall, P.D. and Anderson, T.J. (2009) Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). Journal of Veterinary Internal Medicine, 23(4), pp. 862-870. (doi: 10.1111/j.1939-1676.2009.0337.x)

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi: 10.1002/jnr.21867)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)

Lowrie, M., Penderis, J., Eckersall, P.D., McLaughlin, M. , Mellor, D. and Anderson, T.J. (2009) The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Veterinary Journal, 182(1), pp. 125-130. (doi: 10.1016/j.tvjl.2008.05.001)

Thomson, C.E., McCulloch, M., Sorenson, A., Barnett, S.C. , Seed, B.V., Griffiths, I.R. and McLaughlin, M. (2008) Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. European Journal of Neuroscience, 28(8), pp. 1518-1535. (doi: 10.1111/j.1460-9568.2008.06415.x)

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi: 10.1007/s11064-006-9122-y)

Wyse, C.A., Nixon, C., McLaughlin, M. , Dowell, F.J. and Philbey, A.W. (2006) Evidence for the expression and enzymatic activity of haem oxygenase-1 in the lungs of horses. Veterinary Record, 158(23), pp. 795-798. (doi: 10.1136/vr.158.23.795)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi: 10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J., Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi: 10.1002/glia.20325)

Montague, P., McCallion, A., Barrie, J., Edgar, J., McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi: 10.1002/glia.20155)

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi: 10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J., McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi: 10.1007/s00401-003-0808-9)

Al-Saktawi, K., McLaughlin, M., Klugmann, M., Schneider, A., Barrie, J., McCulloch, M., Montague, P., Kirkham, D., Nave, K. and Griffiths, I. (2003) Genetic background determines phenotypic severity of the Plp rumpshaker mutation. Journal of Neuroscience Research, 72, pp. 12-24. (doi: 10.1002/jnr.10561)

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi: 10.1002/glia.10103) (PMID:12203392)

McLaughlin, M., Hunter, D., Thomson, C., Yool, D. , Kirkham, D., Freer, A. and Griffiths, I. (2002) Evidence for possible interactions between PLP and DM20 within the myelin sheath. Glia, 39(1), pp. 31-36. (doi: 10.1002/glia.10091) (PMID:12112373)

Yool, D.A. , Klugmann, M., McLaughlin, M., Vouyiouklis, D.A., Dimou, L., Barrie, J.A., McCulloch, M.C., Nave, K.-A. and Griffiths, I.R. (2001) Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons. Journal of Neuroscience Research, 63(2), pp. 151-164. (doi: 10.1002/1097-4547(20010115)63:2<151::AID-JNR1007>3.0.CO;2-Y) (PMID:11169625)

O'Neill, C., Anderton, B., Georgopoulou, N., McLaughlin, M. , McFarlane, I. and Breen, K. C. (2001) The role of post-translational modification in ϐ-amyloid precursor protein processing. Biochemical Society Symposia, 67, pp. 23-36. (doi: 10.1042/bss0670023) (PMID:11447837)

Shinomura, T., del Río, E., Breen, K.C., Downes, C.P. and McLaughlin, M. (2000) Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes. British Journal of Pharmacology, 131(5), pp. 1011-1018. (doi: 10.1038/sj.bjp.0703651) (PMID:11053224) (PMCID:PMC1572410)

McLaughlin, M. and Breen, K.C. (1999) Protein kinase C activation potentiates the rapid secretion of the amyloid precursor protein from rat cortical synaptosomes. Journal of Neurochemistry, 72(1), pp. 273-81. (doi: 10.1046/j.1471-4159.1999.0720273.x) (PMID:9886079)

Cousin, M. A., McLaughlin, M. and Nicholls, D. G. (1999) Protein kinase C modulates field-evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin-sensitive K+channel. European Journal of Neuroscience, 11(1), pp. 101-109. (doi: 10.1046/j.1460-9568.1999.00412.x) (PMID:9987015)

Del Río, E., McLaughlin, M. , Downes, C.P. and Nicholls, D.G. (1999) Differential coupling of G-protein-linked receptors to Ca2+mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture. European Journal of Neuroscience, 11(9), pp. 3015-3022. (doi: 10.1046/j.1460-9568.1999.00714.x) (PMID:10510166)

McLaughlin, M. , Inglis, F.M., Ross, B.M., Breen, K.C. and McCulloch, J. (1999) Modest cholinergic deafferentation fails to alter hippocampal G-proteins. Neurochemistry International, 35(1), pp. 59-64. (doi: 10.1016/S0197-0186(99)00033-9) (PMID:10403430)

McLaughlin, M. , Brunton, V., Morrison, V., Rae, A., Cooke, T. and Bartlett, J. (1996) Growth inhibition of gastric cancer cell lines by the tyrphostin RG13022 and its effects on intracellular signalling. International Journal of Oncology, 8(3), pp. 589-596. (doi: 10.3892/ijo.8.3.589) (PMID:21544401)

Ross, B. M., McLaughlin, M. , Roberts, M., Milligan, G. , McCulloch, J. and Knowler, J. T. (1993) Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease. Brain Research, 622(1-2), pp. 35-42. (doi: 10.1016/0006-8993(93)90798-R) (PMID:8242380)

McLaughlin, M. , Ross, B. M., Milligan, G. , McCulloch, J. and Knowler, J. T. (1991) Robustness of G proteins in Alzheimer's disease: an immunoblot study. Journal of Neurochemistry, 57(1), pp. 9-14. (doi: 10.1111/j.1471-4159.1991.tb02092.x) (PMID:1904911)

Book Sections

Eckersall, P. D. and McLaughlin, M. (2011) Proteomics in animal health and disease. In: Eckersall, P. D. and Whitfield, P. D. (eds.) Methods in Animal Proteomics. Wiley-Blackwell, pp. 243-318. ISBN 9780813817910 (doi: 10.1002/9780470960660.ch10)

Conference Proceedings

Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Wilson, D., Herzyk, P. , Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi: 10.1017/S2040470015000023)

Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Herzyk, P. , Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi: 10.3920/978-90-8686-810-0)

This list was generated on Sun May 19 02:19:31 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Validation of biomarkers of cardiomyopathy in Atlantic Salmon
    Biotechnology and Biological Sciences Research Council
    2023 - 2024
     
  • Applied Integrated lipidomics and metabolomics to dissect the mechanisms of canine degenerative myelopathy
    Wellcome Trust
    2021 - 2022
     
  • Joint Doctorate in Molecular Animal Nutrition
    European Commission
    2018 - 2022
     
  • The identification of toxic pathways associated with canine degenerative myelopathy mutant SOD1 protein: a potential model of fALS
    Kuwait Foundation for the Advancement of Sciences
    2018 - 2019
     
  • SFC-GCRF: Biomarker discovery for carriers of haemorrhagic septicaemia in water buffalo
    Scottish Funding Council
    2016 - 2017
     
  • Effects of GnRH blockade on neurocognitive and physiological endpoints.
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Farm Animal Proteomics
    European Commission
    2011 - 2014
     
  • Establishing potential CSF markers of degenerative myelopathy in the dog
    Petsavers
    2009 - 2010
     
  • An investigation of the role of microglia/macrophages in axonal damage, in the context of demyelination
    Multiple Sclerosis Society
    2009 - 2011
     
  • The influence of rumpshaker PLP on other myelin components and myelin stability
    Wellcome Trust
    2005 - 2009
     
  • Proteolipid protein gene dosage and myelination
    Biotechnology and Biological Sciences Research Council
    2003 - 2006
     

Supervision

  • Ciris, Abdulkadir
    Design and evaluation of an innovative visualisation based intervention for the teaching of veterinary anatomy
  • MATSUOKA, MIKI
    Ruminant microbiome - nutritional modulation and immune consequences
  • Smout, John
    The Genetic and Cellular Basis of Viviparity

Research datasets