Dr Mark McLaughlin

Senior Lecturer (Veterinary Science & Education )

telephone: 01413305716or6278
email: Mark.McLaughlin@glasgow.ac.uk

Veterinary Biosciences, Jarrett Building, Glasgow G61 1QH

ORCID iD https://orcid.org/0000-0001-5317-2090

Research interests

My research interests are focused primarily on the molecular basis of neurological disorders. Of special interest are myelin related disorders, canine degenerative myelopathy (DM) and neuronal plasticity mechanisms. Additional research activities involve the application of proteomics in farm animal health, disease and production.

PMD is caused by one of a variety of mutations of the X-linked major myelin protein proteolipid protein gene (Plp1). There is a broad spectrum of neurological abnormalities ranging from a severe connatal PMD resulting in death within the first decade to a late onset with relatively mild spasticity of the lower limbs. My work is concerned with understanding the impact of PLP1 gene mutations on the biochemical processes associated with myelin formation and stability.

For several years our group has been investigating the nature of the pathology associated with degenerative myelopathy (DM). DM affects large breed dogs at older age is characterised by bilateral ataxia paresis affecting hind limbs and in later stages thoracic limbs. The pathology of the spinal cord of DM shows pronounced axonal degeneration and is similar to amyotrophic lateral sclerosis (fALS), a subgroup of human motor neuron disease. We are currently exploring cerebrospinal fluid from DM as a potential source of biomarkers that will assist in diagnosis and provide insight into the disease process. The cellular mechansisms involved in the disease process is also being investigated.

An exciting collaboration with colleagues at the University of Glasgow will explore the impact of the disruption of the hypothalamic pituitary axis on behavior and neuronal plasticity. Understanding the influence of neuroendocrine systems on cognitive and behavioral has implications for a range of human conditions.

I am a member of the COST-Action in Farm Animal Proteomics. This programme has established an interacting network of research scientist with the aim to apply the significant advances in proteomics to benefit farm animal health and welfare, production and food quality. This involves participating scientists across Europe sharing technical expertise, biological material with opportunities for student exchange which will greatly assist in the advancement of veterinary science in health and disease.

Selected Publications

Eckersall PD and McLaughlin M (2011). Proteomics in Animal Health and Disease. In: Methods in Animal Proteomics, First Edition. Edited by Phillip D Whitfield, P David Eckersall. Published 2011 by John Wiley & Sons, Inc.

Karim SA, Barrie JA, McCulloch MC, Montague P, Edgar JM, Iden DL, Anderson TJ, Nave K-A., Griffiths IR, and McLaughlin M. PLP/DM20 expression and turnover in a transgenic mouse model of Pelizaeus-Merzbacher disease. Glia, 58 (2010); 1727-1738.

Lowrie M, Penderis J, Eckersall PD, McLaughlin M, Mellor D, and Anderson TJ, The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Vet. J, 182 (2009); 125-130.

Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, and McLaughlin M. Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. Eur J Neurosci, 28(8) (2008); 1518-1538.

McLaughlin M, Barrie JA, Karim SA, Montague P, Edgar JM, Kirkham D, Thomson CE, and Griffiths IR, Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53 (2006); 715-722.

Edgar JM, McLaughlin M, Barrie JA, McCulloch MC, Garbern J, and Griffiths IR. Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropath. (Berl), 107 (2004); 331-335.

Publications

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Number of items: 58.

2023

Nguyen, T. X. et al. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part I: serum proteomes. Journal of Proteomics, 270, 104740. (doi: 10.1016/j.jprot.2022.104740) (PMID:36191802)

Nguyen, T. X., Agazzo, A., McGill, S., Weidt, S., Han, Q. H., Gelemanović, A., McLaughlin, M. , Savoini, G., Eckersall, P. D. and Burchmore, R. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part II: ileum proteomes. Journal of Proteomics, 270, 104739. (doi: 10.1016/j.jprot.2022.104739) (PMID:36174954)

2022

Nguyen, T. X. et al. (2022) Abundance of plasma proteins in response to divergent ratios of dietary ω6:ω3 fatty acids in gestating and lactating sows using a quantitative proteomics approach. Journal of Proteomics, 260, 104562. (doi: 10.1016/j.jprot.2022.104562) (PMID:35314360)

2021

McGonigal, R. , Barrie, J. A., Yao, D., Black, L. E. , McLaughlin, M. and Willison, H. J. (2021) Neuronally expressed a-series gangliosides are sufficient to prevent the lethal age-dependent phenotype in GM3-only expressing mice. Journal of Neurochemistry, 158(2), pp. 217-232. (doi: 10.1111/jnc.15365) (PMID:33864399)

Almeida, A. M. et al. (2021) Domestic animal proteomics in the 21st century: A global retrospective and viewpoint analysis. Journal of Proteomics, 241, 104220. (doi: 10.1016/j.jprot.2021.104220) (PMID:33838350)

Baka, R. et al. (2021) Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic seizures. Journal of Proteomics, 231, 103997. (doi: 10.1016/j.jprot.2020.103997) (PMID:33011347)

Horvatić, A. et al. (2021) Multi-omics approach to elucidate cerebrospinal fluid changes in dogs with intervertebral disc herniation. International Journal of Molecular Sciences, 22(21), 11678. (doi: 10.3390/ijms222111678)

2020

Pesko, B. K., Weidt, S., McLaughlin, M. , Wescott, D. J., Torrance, H. , Burgess, K. and Burchmore, R. (2020) Post-mortomics: the potential of untargeted metabolomics to highlight markers for time since death. OMICS: A Journal of Integrative Biology, 24(11), pp. 649-659. (doi: 10.1089/omi.2020.0084) (PMID:33095683)

McNaught, K. A., Morris, J. S. and McLaughlin, M. (2020) Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma. Veterinary and Comparative Oncology, 18(3), pp. 292-302. (doi: 10.1111/vco.12550) (PMID:31654603)

Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5), pp. 1383-1399. (doi: 10.1093/brain/awaa080) (PMID:32419025) (PMCID:PMC7462093)

2019

Qi, Y., Montague, P., Loney, C. , Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD 1 protein associated with canine degenerative myelopathy. European Journal of Neuroscience, 50(12), pp. 3896-3905. (doi: 10.1111/ejn.14526) (PMID:31336405)

Hough, D. , Robinson, J.E. , Bellingham, M. , Fleming, L.M., McLaughlin, M. , Jama, K., Haraldsen, I.R.H., Solbakk, A.K. and Evans, N.P. (2019) Peripubertal GnRH and testosterone co-treatment leads to increased familiarity preferences in male sheep. Psychoneuroendocrinology, 108, pp. 70-77. (doi: 10.1016/j.psyneuen.2019.06.008) (PMID:31229635) (PMCID:PMC6712355)

Gutierrez-Quintana, R. , McLaughlin, M. , Grau Roma, L., Hammond, G., Gray, A. and Lowrie, M. (2019) Spongiform leucoencephalomyelopathy in border terriers: clinical, electrophysiological and imaging features. Veterinary Record, 185, 375. (doi: 10.1136/vr.105240) (PMID:31346136)

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)

McGonigal, R. , Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)

2018

Wyse, C.A., Zhang, X., McLaughlin, M. , Biello, S.M. , Hough, D., Bellingham, M. , Curtis, A.M., Robinson, J.E. and Evans, N.P. (2018) Circadian rhythms of melatonin and behaviour in juvenile sheep in field conditions: effects of photoperiod, environment and weaning. Physiology and Behavior, 194, pp. 362-370. (doi: 10.1016/j.physbeh.2018.06.001) (PMID:29894760)

2017

Hough, D. , Bellingham, M. , Haraldsen, J.R., McLaughlin, M. , Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep. Psychoneuroendocrinology, 77, pp. 1-8. (doi: 10.1016/j.psyneuen.2016.11.029) (PMID:27987429) (PMCID:PMC5333793)

Hough, D. , Bellingham, M. , Haraldsen, I.R.H., McLaughlin, M. , Rennie, M., Robinson, J.E. , Solbakk, A.K. and Evans, N.P. (2017) Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep. Psychoneuroendocrinology, 75, pp. 173-182. (doi: 10.1016/j.psyneuen.2016.10.016) (PMID:27837697) (PMCID:PMC5140006)

2016

Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi: 10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)

2015

Braceland, M., McLoughlin, M.F., Tinsley, J., Wallace, C., Cockerill, D., McLaughlin, M. and Eckersall, P.D. (2015) Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. Journal of Fish Diseases, 28(9), pp. 821-831. (doi: 10.1111/jfd.12296) (PMID:25168106)

Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Wilson, D., Herzyk, P. , Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi: 10.1017/S2040470015000023)

2014

Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Herzyk, P. , Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi: 10.3920/978-90-8686-810-0)

Shafie, I. N.F., McLaughlin, M. , Burchmore, R. , Lim, M. A. A., Montague, P., Johnston, P. E.J. , Penderis, J. and Anderson, T. J. (2014) The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog. Cell Stress and Chaperones, 19(3), pp. 311-320. (doi: 10.1007/s12192-013-0457-4)

Almeida, A.M. et al. (2014) Animal board invited review: advances in proteomics for animal and food sciences. Animal, 9(1), pp. 1-17. (doi: 10.1017/S1751731114002602) (PMID:25359324) (PMCID:PMC4301196)

Albalat, A., Husi, H., Siwy, J., Nally, J. E., McLaughlin, M. , Eckersall, P. D. and Mullen, W. (2014) Capillary electrophoresis interfaced with a mass spectrometer (CE-MS): technical considerations and applicability for biomarker studies in animals. Current Protein and Peptide Science, 15(1), pp. 23-35. (doi: 10.2174/1389203715666140221123920) (PMID:24555889)

Ghazali, M., Koh-Tan, H. H., McLaughlin, M. , Montague, P., Jonsson, N. N. and Eckersall, P. (2014) Alkaline phosphatase in nasal secretion of cattle: biochemical and molecular characterisation. BMC Veterinary Research, 10(1), 204. (doi: 10.1186/s12917-014-0204-9) (PMID:25927913) (PMCID:PMC4173004)

McQueen, J., Reimer, M.M., Holland, P.R., Manso, Y., McLaughlin, M. , Fowler, J.H. and Horsburgh, K. (2014) Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. PLoS ONE, 9(2), e87227. (doi: 10.1371/journal.pone.0087227) (PMID:24498301) (PMCID:PMC3911923)

2013

Shafie, I.N.F., Anderson, T.J. , Penderis, J., Eckersall, P.D. and McLaughlin, M. (2013) A protocol for the management of canine cerebrospinal fluid for the proteomic assessment of putative biomarkers. Veterinary Journal, 197(3), pp. 836-841. (doi: 10.1016/j.tvjl.2013.05.039)

2011

Eckersall, P. D. and McLaughlin, M. (2011) Proteomics in animal health and disease. In: Eckersall, P. D. and Whitfield, P. D. (eds.) Methods in Animal Proteomics. Wiley-Blackwell, pp. 243-318. ISBN 9780813817910 (doi: 10.1002/9780470960660.ch10)

2010

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)

Barrie, J.A., Montague, P., Karim, S.A., Kirkham, D., Nave, K.-A., Anderson, T.J. , Griffiths, I.R. and McLaughlin, M. (2010) Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms. Journal of Neuroscience Research, 88(10), pp. 2135-2145. (doi: 10.1002/jnr.22379)

Evans, R.D., Weston, D.A., McLaughlin, M. and Brown, A.M. (2010) A non-linear regression analysis method for quantitative resolution of the stimulus-evoked compound action potential from rodent optic nerve. Journal of Neuroscience Methods, 188(1), pp. 174-178. (doi: 10.1016/j.jneumeth.20%U 10.02.004)

2009

Lowrie, M., Penderis, J., McLaughlin, M. , Eckersall, P.D. and Anderson, T.J. (2009) Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). Journal of Veterinary Internal Medicine, 23(4), pp. 862-870. (doi: 10.1111/j.1939-1676.2009.0337.x)

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi: 10.1002/jnr.21867)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)

Lowrie, M., Penderis, J., Eckersall, P.D., McLaughlin, M. , Mellor, D. and Anderson, T.J. (2009) The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Veterinary Journal, 182(1), pp. 125-130. (doi: 10.1016/j.tvjl.2008.05.001)

2008

Thomson, C.E., McCulloch, M., Sorenson, A., Barnett, S.C. , Seed, B.V., Griffiths, I.R. and McLaughlin, M. (2008) Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. European Journal of Neuroscience, 28(8), pp. 1518-1535. (doi: 10.1111/j.1460-9568.2008.06415.x)

2007

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi: 10.1007/s11064-006-9122-y)

2006

Wyse, C.A., Nixon, C., McLaughlin, M. , Dowell, F.J. and Philbey, A.W. (2006) Evidence for the expression and enzymatic activity of haem oxygenase-1 in the lungs of horses. Veterinary Record, 158(23), pp. 795-798. (doi: 10.1136/vr.158.23.795)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi: 10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J., Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi: 10.1002/glia.20325)

2005

Montague, P., McCallion, A., Barrie, J., Edgar, J., McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi: 10.1002/glia.20155)

2004

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi: 10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J., McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi: 10.1007/s00401-003-0808-9)

2003

Al-Saktawi, K., McLaughlin, M., Klugmann, M., Schneider, A., Barrie, J., McCulloch, M., Montague, P., Kirkham, D., Nave, K. and Griffiths, I. (2003) Genetic background determines phenotypic severity of the Plp rumpshaker mutation. Journal of Neuroscience Research, 72, pp. 12-24. (doi: 10.1002/jnr.10561)

2002

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi: 10.1002/glia.10103) (PMID:12203392)

McLaughlin, M., Hunter, D., Thomson, C., Yool, D. , Kirkham, D., Freer, A. and Griffiths, I. (2002) Evidence for possible interactions between PLP and DM20 within the myelin sheath. Glia, 39(1), pp. 31-36. (doi: 10.1002/glia.10091) (PMID:12112373)

2001

Yool, D.A. , Klugmann, M., McLaughlin, M., Vouyiouklis, D.A., Dimou, L., Barrie, J.A., McCulloch, M.C., Nave, K.-A. and Griffiths, I.R. (2001) Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons. Journal of Neuroscience Research, 63(2), pp. 151-164. (doi: 10.1002/1097-4547(20010115)63:2<151::AID-JNR1007>3.0.CO;2-Y) (PMID:11169625)

O'Neill, C., Anderton, B., Georgopoulou, N., McLaughlin, M. , McFarlane, I. and Breen, K. C. (2001) The role of post-translational modification in ϐ-amyloid precursor protein processing. Biochemical Society Symposia, 67, pp. 23-36. (doi: 10.1042/bss0670023) (PMID:11447837)

2000

Shinomura, T., del Río, E., Breen, K.C., Downes, C.P. and McLaughlin, M. (2000) Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes. British Journal of Pharmacology, 131(5), pp. 1011-1018. (doi: 10.1038/sj.bjp.0703651) (PMID:11053224) (PMCID:PMC1572410)

1999

McLaughlin, M. and Breen, K.C. (1999) Protein kinase C activation potentiates the rapid secretion of the amyloid precursor protein from rat cortical synaptosomes. Journal of Neurochemistry, 72(1), pp. 273-81. (doi: 10.1046/j.1471-4159.1999.0720273.x) (PMID:9886079)

Cousin, M. A., McLaughlin, M. and Nicholls, D. G. (1999) Protein kinase C modulates field-evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin-sensitive K+channel. European Journal of Neuroscience, 11(1), pp. 101-109. (doi: 10.1046/j.1460-9568.1999.00412.x) (PMID:9987015)

Del Río, E., McLaughlin, M. , Downes, C.P. and Nicholls, D.G. (1999) Differential coupling of G-protein-linked receptors to Ca2+mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture. European Journal of Neuroscience, 11(9), pp. 3015-3022. (doi: 10.1046/j.1460-9568.1999.00714.x) (PMID:10510166)

McLaughlin, M. , Inglis, F.M., Ross, B.M., Breen, K.C. and McCulloch, J. (1999) Modest cholinergic deafferentation fails to alter hippocampal G-proteins. Neurochemistry International, 35(1), pp. 59-64. (doi: 10.1016/S0197-0186(99)00033-9) (PMID:10403430)

1996

McLaughlin, M. , Brunton, V., Morrison, V., Rae, A., Cooke, T. and Bartlett, J. (1996) Growth inhibition of gastric cancer cell lines by the tyrphostin RG13022 and its effects on intracellular signalling. International Journal of Oncology, 8(3), pp. 589-596. (doi: 10.3892/ijo.8.3.589) (PMID:21544401)

1993

Ross, B. M., McLaughlin, M. , Roberts, M., Milligan, G. , McCulloch, J. and Knowler, J. T. (1993) Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease. Brain Research, 622(1-2), pp. 35-42. (doi: 10.1016/0006-8993(93)90798-R) (PMID:8242380)

1991

McLaughlin, M. , Ross, B. M., Milligan, G. , McCulloch, J. and Knowler, J. T. (1991) Robustness of G proteins in Alzheimer's disease: an immunoblot study. Journal of Neurochemistry, 57(1), pp. 9-14. (doi: 10.1111/j.1471-4159.1991.tb02092.x) (PMID:1904911)

This list was generated on Sun Jan 29 12:54:10 2023 GMT.

Jump to: Articles | Book Sections | Conference Proceedings

Number of items: 58.

Articles

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Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Applied Integrated lipidomics and metabolomics to dissect the mechanisms of canine degenerative myelopathy
Wellcome Trust
2021 - 2022
Joint Doctorate in Molecular Animal Nutrition
European Commission
2018 - 2022
The identification of toxic pathways associated with canine degenerative myelopathy mutant SOD1 protein: a potential model of fALS
Kuwait Foundation for the Advancement of Sciences
2018 - 2019
SFC-GCRF: Biomarker discovery for carriers of haemorrhagic septicaemia in water buffalo
Scottish Funding Council
2016 - 2017
Effects of GnRH blockade on neurocognitive and physiological endpoints.
Biotechnology and Biological Sciences Research Council
2013 - 2016
Farm Animal Proteomics
European Commission
2011 - 2014
Establishing potential CSF markers of degenerative myelopathy in the dog
Petsavers
2009 - 2010
An investigation of the role of microglia/macrophages in axonal damage, in the context of demyelination
Multiple Sclerosis Society
2009 - 2011
The influence of rumpshaker PLP on other myelin components and myelin stability
Wellcome Trust
2005 - 2009
Proteolipid protein gene dosage and myelination
Biotechnology and Biological Sciences Research Council
2003 - 2006

Supervision

Black, Lauren
Identification of potential serum biomarkers of canine degenerative myelopathy (CDM) and characterisation of potential pathological mechanisms associated with mutant SOD1 toxicity
Ciris, Abdulkadir
Design and evaluation of an innovative visualisation based intervention for the teaching of veterinary anatomy
Jones, Rheinallt
Investigation of faecal proteomes and metabolomes of cattle and sheep fed on high- and low-starch diets
Peinado, Jorge
Protein synthesis rates
Smout, John
MVLS DTP - World class underpinning bioscience

Research datasets

Jump to: 2019

Number of items: 1.

2019

Qi, Y., Montague, P., Loney, C., Campbell, C., Shafie, I., Anderson, T. and McLaughlin, M. (2019) In vitro evidence consistent with an interaction between wild type and a mutant SOD1 protein associated with canine degenerative myelopathy. [Data Collection]

This list was generated on Sun Jan 29 16:51:24 2023 GMT.

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Dr Mark McLaughlin

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