Dr Mark McLaughlin
- Senior Lecturer (Veterinary Science & Education )
My research interests are focused primarily on the molecular basis of neurological disorders. Of special interest are myelin related disorders, canine degenerative myelopathy (DM) and neuronal plasticity mechanisms. Additional research activities involve the application of proteomics in farm animal health, disease and production.
PMD is caused by one of a variety of mutations of the X-linked major myelin protein proteolipid protein gene (Plp1). There is a broad spectrum of neurological abnormalities ranging from a severe connatal PMD resulting in death within the first decade to a late onset with relatively mild spasticity of the lower limbs. My work is concerned with understanding the impact of PLP1 gene mutations on the biochemical processes associated with myelin formation and stability.
For several years our group has been investigating the nature of the pathology associated with degenerative myelopathy (DM). DM affects large breed dogs at older age is characterised by bilateral ataxia paresis affecting hind limbs and in later stages thoracic limbs. The pathology of the spinal cord of DM shows pronounced axonal degeneration and is similar to amyotrophic lateral sclerosis (fALS), a subgroup of human motor neuron disease. We are currently exploring cerebrospinal fluid from DM as a potential source of biomarkers that will assist in diagnosis and provide insight into the disease process. The cellular mechansisms involved in the disease process is also being investigated.
An exciting collaboration with colleagues at the University of Glasgow will explore the impact of the disruption of the hypothalamic pituitary axis on behavior and neuronal plasticity. Understanding the influence of neuroendocrine systems on cognitive and behavioral has implications for a range of human conditions.
I am a member of the COST-Action in Farm Animal Proteomics. This programme has established an interacting network of research scientist with the aim to apply the significant advances in proteomics to benefit farm animal health and welfare, production and food quality. This involves participating scientists across Europe sharing technical expertise, biological material with opportunities for student exchange which will greatly assist in the advancement of veterinary science in health and disease.
- Eckersall PD and McLaughlin M (2011). Proteomics in Animal Health and Disease. In: Methods in Animal Proteomics, First Edition. Edited by Phillip D Whitfield, P David Eckersall. Published 2011 by John Wiley & Sons, Inc.
- Karim SA, Barrie JA, McCulloch MC, Montague P, Edgar JM, Iden DL, Anderson TJ, Nave K-A., Griffiths IR, and McLaughlin M. PLP/DM20 expression and turnover in a transgenic mouse model of Pelizaeus-Merzbacher disease. Glia, 58 (2010); 1727-1738.
- Lowrie M, Penderis J, Eckersall PD, McLaughlin M, Mellor D, and Anderson TJ, The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. Vet. J, 182 (2009); 125-130.
- Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, and McLaughlin M. Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. Eur J Neurosci, 28(8) (2008); 1518-1538.
- McLaughlin M, Barrie JA, Karim SA, Montague P, Edgar JM, Kirkham D, Thomson CE, and Griffiths IR, Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53 (2006); 715-722.
- Edgar JM, McLaughlin M, Barrie JA, McCulloch MC, Garbern J, and Griffiths IR. Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropath. (Berl), 107 (2004); 331-335.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Applied Integrated lipidomics and metabolomics to dissect the mechanisms of canine degenerative myelopathy
2021 - 2022
- Joint Doctorate in Molecular Animal Nutrition
2018 - 2022
- The identification of toxic pathways associated with canine degenerative myelopathy mutant SOD1 protein: a potential model of fALS
Kuwait Foundation for the Advancement of Sciences
2018 - 2019
- SFC-GCRF: Biomarker discovery for carriers of haemorrhagic septicaemia in water buffalo
Scottish Funding Council
2016 - 2017
- Effects of GnRH blockade on neurocognitive and physiological endpoints.
Biotechnology and Biological Sciences Research Council
2013 - 2016
- Farm Animal Proteomics
2011 - 2014
- Establishing potential CSF markers of degenerative myelopathy in the dog
2009 - 2010
- An investigation of the role of microglia/macrophages in axonal damage, in the context of demyelination
Multiple Sclerosis Society
2009 - 2011
- The influence of rumpshaker PLP on other myelin components and myelin stability
2005 - 2009
- Proteolipid protein gene dosage and myelination
Biotechnology and Biological Sciences Research Council
2003 - 2006
- Black, Lauren
Identification of potential serum biomarkers of canine degenerative myelopathy (CDM) and characterisation of potential pathological mechanisms associated with mutant SOD1 toxicity
- Ciris, Abdulkadir
Design and evaluation of an innovative visualisation based intervention for the teaching of veterinary anatomy
- Peinado, Jorge
Protein synthesis rates
- Riosa, Ruben
Assessment of the effects of increased intakes of the amino
- Smout, John
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