Dr Rea Laila Antoniou Kourounioti

  • Lecturer (Molecular Biosciences)

email: ReaLaila.AntoniouKourounioti@glasgow.ac.uk
pronouns: She/her/hers

Room 421, Bower Building, University of Glasgow, School of Molecular Biosciences, College of Medical, Veterinary & Life Sciences, Glasgow, G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-5226-521X

Biography

I studied Biology at Imperial College, London, and Mathematics at the University of Crete, Greece, with the intention of combining the two in interdisciplinary science. I then obtained my PhD from the University of Nottingham in 2014, in which I utilised my multi-disciplinary background in a project on artificial photosynthesis. The work resulted in a novel hybrid material, which combined the light harvesting complex from plants with an inorganic catalyst, and used visible light to convert CO2 into fuel.

Following my PhD, I did a postdoc at the John Innes Centre working with Martin Howard and Caroline Dean on the epigenetic and environmental control of flowering time, in Arabidopsis, by the process of vernalization. I used mathematical modelling and experimental methods to understand the temperature sensing in this pathway and to investigate the strength of the epigenetic memory, which depends on natural adaptation.

In 2022 I joined the University of Glasgow as a lecturer in the School of Molecular Biosciences where I am working to uncover how plants sense temperature.

Research interests

My research focuses on plants’ response to temperature. I am particularly interested in how plants react to cold temperatures, as a reduction in cold periods with global warming will have significant effects on plant development and their ability to recognise the seasons. Furthermore, unseasonable cold or warm periods, another consequence of climate change, can lead to increased stress when plants are not appropriately prepared for the weather, at the molecular or developmental level.

I am investigating the molecular changes that happen in plants in response to temperature and aim to predict these in future climates. My previous research has shown that temperature sensing is “distributed”, meaning that multiple molecules and processes are affected by temperature, and these are combined by the plant into the temperature input signal. To understand this complicated integration problem, mathematical modelling is a key method that we use.

In the group we combine mathematical modelling and biological experiments. Based on the biological knowledge from experiments including molecular biology, genetics, omics and cell biology, we build a mathematical model to describe the system and gain insights into how it works and where we need to put more effort to understand it. The next step is to go back in the lab and do the experiments that will answer the questions pointed out by the modelling.

Research groups

Publications

List by: Type | Date

Jump to: 2023 | 2021 | 2020 | 2018 | 2017 | 2014 | 2013
Number of items: 15.

2023

Zhang, J. et al. (2023) Single amino acid change alters specificity of the multi-allelic wheat stem rust resistance locus SR9. Nature Communications, 14, 7354. (doi: 10.1038/s41467-023-42747-9) (PMID:37963867) (PMCID:PMC10645757)

Antoniou-Kourounioti, R. L. et al. (2023) Integrating analog and digital modes of gene expression at Arabidopsis FLC. eLife, 12, e79743. (doi: 10.7554/elife.79743) (PMID:37466633) (PMCID:PMC10356135)

Auge, G., Hankofer, V., Groth, M., Antoniou-Kourounioti, R. , Ratikainen, I. and Lampei, C. (2023) Plant environmental memory: implications, mechanisms, and opportunities for plant scientists and beyond. AoB Plants, 15(4), plad032. (doi: 10.1093/aobpla/plad032) (PMID:37415723) (PMCID:PMC10321398)

Arora, S. et al. (2023) A wheat kinase and immune receptor form host-specificity barriers against the blast fungus. Nature Plants, 9(3), pp. 385-392. (doi: 10.1038/s41477-023-01357-5) (PMID:36797350)

2021

Zhao, Y., Zhu, P., Hepworth, J., Bloomer, R., Antoniou-Kourounioti, R. L. , Doughty, J., Heckmann, A., Xu, C., Yang, H. and Dean, C. (2021) Natural temperature fluctuations promote COOLAIR regulation of FLC. Genes and Development, 35(11-12), pp. 888-898. (doi: 10.1101/gad.348362.121) (PMID:33985972) (PMCID:PMC8168555)

Antoniou-Kourounioti, R. L. , Zhao, Y., Dean, C. and Howard, M. (2021) Feeling every bit of winter - distributed temperature sensitivity in vernalization. Frontiers in Plant Science, 12, 628726. (doi: 10.3389/fpls.2021.628726) (PMID:33584778) (PMCID:PMC7873433)

2020

Jarad, M., Antoniou-Kourounioti, R. L. , Hepworth, J. and Qüesta, J. I. (2020) Unique and contrasting effects of light and temperature cues on plant transcriptional programs. Transcription, 11(3-4), pp. 134-159. (doi: 10.1080/21541264.2020.1820299) (PMID:33016207) (PMCID:PMC7714439)

Hepworth, J. et al. (2020) Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes. eLife, 9, e57671. (doi: 10.7554/eLife.57671) (PMID:32902380) (PMCID:PMC7518893)

Zhao, Y., Antoniou-Kourounioti, R. L. , Calder, G., Dean, C. and Howard, M. (2020) Temperature-dependent growth contributes to long-term cold sensing. Nature, 583, pp. 825-829. (doi: 10.1038/s41586-020-2485-4) (PMID:32669706) (PMCID:PMC7116785)

Qüesta, J. I., Antoniou-Kourounioti, R. L. , Rosa, S., Li, P., Duncan, S., Whittaker, C., Howard, M. and Dean, C. (2020) Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC. Genes and Development, 34, pp. 446-461. (doi: 10.1101/gad.333245.119) (PMID:32001513) (PMCID:PMC7050481)

2018

Antoniou-Kourounioti, R. L. , Hepworth, J., Heckmann, A., Duncan, S., Qüesta, J., Rosa, S., Säll, T., Holm, S., Dean, C. and Howard, M. (2018) Temperature sensing is distributed throughout the regulatory network that controls FLC epigenetic silencing in vernalization. Cell Systems, 7(6), 643-655.e9. (doi: 10.1016/j.cels.2018.10.011) (PMID:30503646) (PMCID:PMC6310686)

Hepworth, J. et al. (2018) Absence of warmth permits epigenetic memory of winter in Arabidopsis. Nature Communications, 9(1), 639. (doi: 10.1038/s41467-018-03065-7) (PMID:9434233) (PMCID:PMC5809604)

2017

Antoniou-Kourounioti, R. and Howard, M. (2017) Quantitative environmentally triggered switching between stable epigenetic states. In: Ringrose, L. (ed.) Epigenetics and Systems Biology. Series: Translational Epigenetics. Academic Press, pp. 169-187. ISBN 9780128030752 (doi: 10.1016/B978-0-12-803075-2.00008-8)

2014

Lee, C.-W., Antoniou-Kourounioti, R. , Wu, J. C.S., Murchie, E., Maroto-Valer, M., Jensen, O., Huang, C. W. and Ruban, A. (2014) Photocatalytic conversion of CO2 to hydrocarbons by light-harvesting complex assisted Rh-doped TiO2 photocatalyst. Journal of CO2 Utilization, 5, pp. 33-40. (doi: 10.1016/j.jcou.2013.12.002)

2013

Antoniou Kourounioti, R. L. , Band, L. R., Fozard, J. A., Hampstead, A., Lovrics, A., Moyroud, E., Vignolini, S., King, J. R., Jensen, O. and Glover, B. J. (2013) Buckling as an origin of ordered cuticular patterns in flower petals. Journal of the Royal Society: Interface, 10(80), 20120847. (doi: 10.1098/rsif.2012.0847) (PMID:23269848) (PMCID:PMC3565735)

This list was generated on Fri Feb 23 01:32:38 2024 GMT.
Number of items: 15.

Articles

Zhang, J. et al. (2023) Single amino acid change alters specificity of the multi-allelic wheat stem rust resistance locus SR9. Nature Communications, 14, 7354. (doi: 10.1038/s41467-023-42747-9) (PMID:37963867) (PMCID:PMC10645757)

Antoniou-Kourounioti, R. L. et al. (2023) Integrating analog and digital modes of gene expression at Arabidopsis FLC. eLife, 12, e79743. (doi: 10.7554/elife.79743) (PMID:37466633) (PMCID:PMC10356135)

Auge, G., Hankofer, V., Groth, M., Antoniou-Kourounioti, R. , Ratikainen, I. and Lampei, C. (2023) Plant environmental memory: implications, mechanisms, and opportunities for plant scientists and beyond. AoB Plants, 15(4), plad032. (doi: 10.1093/aobpla/plad032) (PMID:37415723) (PMCID:PMC10321398)

Arora, S. et al. (2023) A wheat kinase and immune receptor form host-specificity barriers against the blast fungus. Nature Plants, 9(3), pp. 385-392. (doi: 10.1038/s41477-023-01357-5) (PMID:36797350)

Zhao, Y., Zhu, P., Hepworth, J., Bloomer, R., Antoniou-Kourounioti, R. L. , Doughty, J., Heckmann, A., Xu, C., Yang, H. and Dean, C. (2021) Natural temperature fluctuations promote COOLAIR regulation of FLC. Genes and Development, 35(11-12), pp. 888-898. (doi: 10.1101/gad.348362.121) (PMID:33985972) (PMCID:PMC8168555)

Antoniou-Kourounioti, R. L. , Zhao, Y., Dean, C. and Howard, M. (2021) Feeling every bit of winter - distributed temperature sensitivity in vernalization. Frontiers in Plant Science, 12, 628726. (doi: 10.3389/fpls.2021.628726) (PMID:33584778) (PMCID:PMC7873433)

Jarad, M., Antoniou-Kourounioti, R. L. , Hepworth, J. and Qüesta, J. I. (2020) Unique and contrasting effects of light and temperature cues on plant transcriptional programs. Transcription, 11(3-4), pp. 134-159. (doi: 10.1080/21541264.2020.1820299) (PMID:33016207) (PMCID:PMC7714439)

Hepworth, J. et al. (2020) Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes. eLife, 9, e57671. (doi: 10.7554/eLife.57671) (PMID:32902380) (PMCID:PMC7518893)

Zhao, Y., Antoniou-Kourounioti, R. L. , Calder, G., Dean, C. and Howard, M. (2020) Temperature-dependent growth contributes to long-term cold sensing. Nature, 583, pp. 825-829. (doi: 10.1038/s41586-020-2485-4) (PMID:32669706) (PMCID:PMC7116785)

Qüesta, J. I., Antoniou-Kourounioti, R. L. , Rosa, S., Li, P., Duncan, S., Whittaker, C., Howard, M. and Dean, C. (2020) Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC. Genes and Development, 34, pp. 446-461. (doi: 10.1101/gad.333245.119) (PMID:32001513) (PMCID:PMC7050481)

Antoniou-Kourounioti, R. L. , Hepworth, J., Heckmann, A., Duncan, S., Qüesta, J., Rosa, S., Säll, T., Holm, S., Dean, C. and Howard, M. (2018) Temperature sensing is distributed throughout the regulatory network that controls FLC epigenetic silencing in vernalization. Cell Systems, 7(6), 643-655.e9. (doi: 10.1016/j.cels.2018.10.011) (PMID:30503646) (PMCID:PMC6310686)

Hepworth, J. et al. (2018) Absence of warmth permits epigenetic memory of winter in Arabidopsis. Nature Communications, 9(1), 639. (doi: 10.1038/s41467-018-03065-7) (PMID:9434233) (PMCID:PMC5809604)

Lee, C.-W., Antoniou-Kourounioti, R. , Wu, J. C.S., Murchie, E., Maroto-Valer, M., Jensen, O., Huang, C. W. and Ruban, A. (2014) Photocatalytic conversion of CO2 to hydrocarbons by light-harvesting complex assisted Rh-doped TiO2 photocatalyst. Journal of CO2 Utilization, 5, pp. 33-40. (doi: 10.1016/j.jcou.2013.12.002)

Antoniou Kourounioti, R. L. , Band, L. R., Fozard, J. A., Hampstead, A., Lovrics, A., Moyroud, E., Vignolini, S., King, J. R., Jensen, O. and Glover, B. J. (2013) Buckling as an origin of ordered cuticular patterns in flower petals. Journal of the Royal Society: Interface, 10(80), 20120847. (doi: 10.1098/rsif.2012.0847) (PMID:23269848) (PMCID:PMC3565735)

Book Sections

Antoniou-Kourounioti, R. and Howard, M. (2017) Quantitative environmentally triggered switching between stable epigenetic states. In: Ringrose, L. (ed.) Epigenetics and Systems Biology. Series: Translational Epigenetics. Academic Press, pp. 169-187. ISBN 9780128030752 (doi: 10.1016/B978-0-12-803075-2.00008-8)

This list was generated on Fri Feb 23 01:32:38 2024 GMT.