Dr Marie Freel

Honorary Clinical Associate Professor (School of Medicine, Dentistry & Nursing)

Queen Elizabeth University Hospital, Office Block, Glasgow, G51 4TF

Publications

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Number of items: 39.

2019

Connelly, Paul J. ORCID: https://orcid.org/0000-0002-1744-9977, Freel, E. Marie, Perry, Colin, Ewan, John, Touyz, Rhian M. ORCID: https://orcid.org/0000-0003-0670-0887, Currie, Gemma ORCID: https://orcid.org/0000-0002-0797-0224 and Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612 (2019) Gender-affirming hormone therapy, vascular health and cardiovascular disease in transgender adults. Hypertension, 74(6), pp. 1266-1274. (doi: 10.1161/HYPERTENSIONAHA.119.13080) (PMID:31656099) (PMCID:PMC6887638)

2018

Taylor, Alison H.M., Rankin, Alastair J. ORCID: https://orcid.org/0000-0001-9031-481X, McQuarrie, Emily P., Freel, Marie, Homer, Natalie Z.M., Andrew, Ruth, Jardine, Alan G. ORCID: https://orcid.org/0000-0001-5815-9370 and Mark, Patrick B. ORCID: https://orcid.org/0000-0003-3387-2123 (2018) Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease. Clinical Science, 132(2), pp. 285-294. (doi: 10.1042/CS20171603) (PMID:29321218)

2017

Freel, Marie (2017) Primary aldosteronism or not primary aldosteronism: Is this now the question in normotension? Hypertension, 69(5), pp. 780-781. (doi: 10.1161/HYPERTENSIONAHA.117.09050) (PMID:28289179)

MacKenzie, Scott M. ORCID: https://orcid.org/0000-0002-4593-4101, Freel, Marie, Connell, John M., Fraser, Robert and Davies, Eleanor ORCID: https://orcid.org/0000-0001-8128-5404 (2017) ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure. International Journal of Molecular Sciences, 18(3), 579. (doi: 10.3390/ijms18030579) (PMID:28272372) (PMCID:PMC5372595)

2016

Diver, L. A. et al. (2016) Common polymorphisms at the CYP17A1 locus associate with steroid phenotype: support for blood pressure genome-wide association study signals at this locus. Hypertension, 67(4), pp. 724-732. (doi: 10.1161/HYPERTENSIONAHA.115.06925) (PMID:26902494) (PMCID:PMC4789491)

2015

Rutherford, M.A., Rankin, A.J. ORCID: https://orcid.org/0000-0001-9031-481X, Yates, T.M., Mark, P.B. ORCID: https://orcid.org/0000-0003-3387-2123, Perry, C.G., Reed, N.S. and Freel, E.M. (2015) Management of metastatic phaeochromocytoma and paraganglioma: use of Iodine-131-meta-iodobenzylguanidine (131I-MIBG) therapy in a tertiary referral centre. QJM: An International Journal of Medicine, 108(5), pp. 361-368. (doi: 10.1093/qjmed/hcu208) (PMID:25267727)

Currie, Gemma ORCID: https://orcid.org/0000-0002-0797-0224, Carty, David M., Connell, John M. and Freel, Marie (2015) Endocrine aspects of pre-eclampsia. Cardiovascular Endocrinology, 4(1), pp. 1-10. (doi: 10.1097/XCE.0000000000000039)

Freel, Ellen Marie (2015) Adrenal vein sampling: is there now a consensus? Clinical Endocrinology, 82(1), pp. 35-36. (doi: 10.1111/cen.12675)

Perry, Colin G., Freel, E. Marie, O'Dwyer, Patrick, Schiffrin, Ernesto L., Jennings, Garry L., Dominiczak, Anna F. ORCID: https://orcid.org/0000-0003-4913-3608 and De Buyzere, Marc (2015) Rare cause of severe hypertension in a young woman. Hypertension, 65(1), pp. 21-24. (doi: 10.1161/HYPERTENSIONAHA.114.04619) (PMID:25385763)

2014

McQuarrie, Emily P., Traynor, Jamie P., Taylor, Alison H., Freel, E. Marie, Fox, Jonathan G., Jardine, Alan G. ORCID: https://orcid.org/0000-0001-5815-9370 and Mark, Patrick ORCID: https://orcid.org/0000-0003-3387-2123 (2014) Association between urinary sodium, creatinine, albumin, and long term survival in chronic kidney disease. Hypertension, 64(1), pp. 111-117. (doi: 10.1161/HYPERTENSIONAHA.113.03093)

Mark, P.B. ORCID: https://orcid.org/0000-0003-3387-2123, Boyle, S., Zimmerli, L.U., McQuarrie, E.P., Delles, C. ORCID: https://orcid.org/0000-0003-2238-2612 and Freel, E.M. (2014) Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study. Journal of Human Hypertension, 28(2), pp. 92-97. (doi: 10.1038/jhh.2013.70)

Freel, E. Marie, Perry, Colin G., O'Dwyer, Patrick, Staessen, Jan A., Jennings, Garry L., Granger, Joey P., De Buyzere, Marc and Schiffrin, Ernesto L. (2014) An unusual cause of mineralocorticoid hypertension. Hypertension, 64(4), pp. 689-692. (doi: 10.1161/HYPERTENSIONAHA.114.04401) (PMID:25156173)

2013

McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62(5), pp. 836-843. (doi: 10.1161/HYPERTENSIONAHA.113.01793)

Freel, E.M., Nicholas, R.S., Sudarshan, T., Priba, L., Gandy, S.J., McMillan, N., Houston, J.G. and Connell, J.M. (2013) Assessment of the accuracy and reproducibility of adrenal volume measurements using MRI and its relationship with corticosteroid phenotype: a normal volunteer pilot study. Clinical Endocrinology, 79(4), pp. 484-490. (doi: 10.1111/cen.12193)

McQuarrie, E.P., Freel, E.M., Mark, P.B. ORCID: https://orcid.org/0000-0003-3387-2123, Fraser, R., Connell, J.M.C. and Jardine, A.G. ORCID: https://orcid.org/0000-0001-5815-9370 (2013) Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease. Nephrology Dialysis Transplantation, 28(6), pp. 1526-1532. (doi: 10.1093/ndt/gft007)

Delles, C. ORCID: https://orcid.org/0000-0003-2238-2612 and Freel, E.M. (2013) Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved? Hypertension, 61(5), pp. 958-960. (doi: 10.1161/HYPERTENSIONAHA.111.00767)

2012

Freel, E. Marie, Mark, Patrick B. ORCID: https://orcid.org/0000-0003-3387-2123, Weir, Robin A.P., McQuarrie, Emily P., Allan, Karen, Dargie, Henry J., McClure, John D. ORCID: https://orcid.org/0000-0003-4839-5462, Jardine, Alan G. ORCID: https://orcid.org/0000-0001-5815-9370, Davies, Eleanor ORCID: https://orcid.org/0000-0001-8128-5404 and Connell, John M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5(6), pp. 740-747. (doi: 10.1161/CIRCIMAGING.112.974576)

Davidson, D. Fraser, Bradshaw, Nicola, Perry, Colin G., Lindsay, Robert ORCID: https://orcid.org/0000-0002-9868-5217 and Freel, E. Marie (2012) Urinary free (unconjugated) metadrenalines in different hereditary forms of catecholamine-secreting phaeochromocytoma/paraganglioma. Annals of Clinical Biochemistry, 49(5), pp. 486-490. (doi: 10.1258/acb.2012.012021)

McQuarrie, Emily P., Freel, E. Marie, Mark, Patrick B. ORCID: https://orcid.org/0000-0003-3387-2123, Fraser, Robert, Patel, Rajan K., Dargie, Henry G., Connell, John M. C. and Jardine, Alan G. ORCID: https://orcid.org/0000-0001-5815-9370 (2012) Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease. Clinical Science, 123(5), pp. 285-294. (doi: 10.1042/CS20120015)

Collier, A., Ghosh, S., Breckenridge, A., Perry, C.G., Freel, E.M. and Davidson, D.F. (2012) A phaeochromocytoma occurring in a patient with Parkinson’s disease on l-dopa therapy: a diagnostic challenge. Clinical Endocrinology, 76(5), pp. 763-764. (doi: 10.1111/j.1365-2265.2011.04266.x)

Currie, Gemma ORCID: https://orcid.org/0000-0002-0797-0224, Freel, E. Marie, Perry, Colin G. and Dominiczak, Anna F. ORCID: https://orcid.org/0000-0003-4913-3608 (2012) Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism. Current Hypertension Reports, 14(1), pp. 38-45. (doi: 10.1007/s11906-011-0239-2)

2011

Yeap, P. M. et al. (2011) Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effect. Journal of Clinical Endocrinology and Metabolism, 96(12), E2009-E2013. (doi: 10.1210/jc.2011-1244)

Shaheen, B., Irvine, F., Freel, M., O'Mahony, O., Shankland, G.S., Matthews, D. and Wainwright, N.J. (2011) Tinea incognito complicating Cushing's syndrome secondary to a bronchial carcinoid tumour. European Journal of Dermatology, 21(5), pp. 805-806. (doi: 10.1684/ejd.2011.1481)

Alvarez-Madrazo, S., Connell, J.M. and Freel, E.M. (2011) Role of genetic variation in regulation of aldosterone biosynthesis. Endocrine Development, 20, pp. 106-115. [Book Review]

2010

Freel, E. Marie, Stanson, Anthony W., Thompson, Geoffrey B., Grant, Clive S., Farley, David R., Richards, Melanie L. and Young, William F. (2010) Adrenal venous sampling for catecholamines: a normal value study. Journal of Clinical Endocrinology and Metabolism, 95(3), pp. 1328-1332. (doi: 10.1210/jc.2009-2253)

Freel, E.M. (2010) Pharmacogenetics: so near and yet so far? Journal of Hypertension, 28(4), pp. 671-672. (doi: 10.1097/HJH.0b013e32833749fd)

2009

Freel, E.M., Tsorlalis, I.K., Lewsey, J.D., Latini, R., Maggioni, A.P., Solomon, S., Pitt, B., Connell, J.M.C. and McMurray, J.J.V. (2009) Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study. Heart, 95(23), pp. 1920-1924. (doi: 10.1136/hrt.2009.173344)

McManus, F., MacKenzie, S.M. and Freel, E.M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11(3), pp. 224-230. (doi: 10.1007/s11906-009-0039-0)

Davies, Eleanor, MacKenzie, Scott M., Freel, E. Marie, Alvarez-Madrazo, Samantha, Fraser, Robert and Connell, John M.C. (2009) Altered corticosteroid biosynthesis in essential hypertension: a digenic phenomenon. Molecular and Cellular Endocrinology, 300(1-2), pp. 185-191. (doi: 10.1016/j.mce.2008.09.014)

2008

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E. ORCID: https://orcid.org/0000-0001-8128-5404 and Connell, J.M.C. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68(5), pp. 700-706. (doi: 10.1111/j.1365-2265.2007.03116.x)

Connell, John M.C., MacKenzie, Scott M. ORCID: https://orcid.org/0000-0002-4593-4101, Freel, E. Marie, Fraser, Robert and Davies, Eleanor ORCID: https://orcid.org/0000-0001-8128-5404 (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29(2), pp. 133-154. (doi: 10.1210/er.2007-0030)

2007

Freel, E.M. et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67(6), pp. 832-838. (doi: 10.1111/j.1365-2265.2007.02971.x)

Thomson, A.H., Devers, M.C., Wallace, A.M., Grant, D., Campbell, K., Freel, E.M. and Connell, J.M.C. (2007) Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clinical Endocrinology, 66(6), pp. 789-796. (doi: 10.1111/j.1365-2265.2007.02812.x)

Freel, E.M., Bernhardt, M., Ingram, R., Wallace, A.M., Fraser, R., Davies, E. and Connell, J.M.C. (2007) Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy. Clinical Endocrinology, 66(5), pp. 659-665. (doi: 10.1111/j.1365-2265.2007.02791.x)

2006

Imrie, H. et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91(12), pp. 5051-5056. (doi: 10.1210/jc.2006-1481)

2005

Freel, E. Marie and Connell, John M. C. (2005) Diagnosis of adenomatous primary aldosteronism in a patient with severe hypertension. Nature Clinical Practice Endocrinology and Metabolism, 1(2), pp. 111-115. (doi: 10.1038/ncpendmet0047)

2004

Freel, E.M., Shakerdi, L., Friel, E., Wallace, A.M., Davies, E. ORCID: https://orcid.org/0000-0001-8128-5404, Fraser, R. and Connell, J.M.C. (2004) The origin of circulating 18-oxo and 18-hydroxycortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89(9), pp. 4628-4633. (doi: 10.1210/jc.2004-0379)

Freel, E.M. and Connell, J.M.C. (2004) Mechanisms of hypertension: the expanding role of aldosterone. Journal of the American Society of Nephrology, 15(8), pp. 1993-2001. (doi: 10.1097/01.ASN.0000132473.50966.14)

1997

Brock, J.H., Bhandari, S. and Freel, E.M. (1997) Modulation of iron-regulatory protein (IRP) activity in monocytes by nitric oxide, phorbol ester and gamma-interferon. Biochemical Society Transactions, 25(2), 193S.

This list was generated on Tue Jun 17 16:38:38 2025 BST.

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