Dr Domenico Somma
- Research Associate (Immunology & Infection)
telephone:
8134
email:
Domenico.Somma@glasgow.ac.uk
B413 Sir Graeme Davies Building, Institute of Infection, Immunity and Inflammation, G12 8TA
Publications
2022
Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)
2021
Somma, D., Kok, F. O., Kerrigan, D., Wells, C. A. and Carmody, R. J. (2021) Defining the role of nuclear factor NF-κB p105 subunit in human macrophage by transcriptomic analysis of NFKB1 knockout THP-1 cells. Frontiers in Immunology, 12, 669906. (doi: 10.3389/fimmu.2021.669906) (PMCID:PMC8548695)
MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)
2020
Mitxitorena, I., Somma, D., Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E. L., Kiely, P. A., Walden, H. , Keeshan, K. and Carmody, R. J. (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry, 295(33), pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113) (PMID:32587091) (PMCID:PMC7450122)
Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)
2019
Collins, P. E., Somma, D., Kerrigan, D., Herrington, F., Keeshan, K. R. , Nibbs, R. J.B. and Carmody, R. J. (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 25828-25838. (doi: 10.1073/pnas.1900408116) (PMID:31772019) (PMCID:PMC6926074)
Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi: 10.1093/nar/gkz873) (PMID:31598684) (PMCID:PMC6868378)
2018
Barra, G. et al. (2018) Sphingosine Kinases promote IL-17 expression in human T lymphocytes. Scientific Reports, 8, 13233. (doi: 10.1038/s41598-018-31666-1) (PMID:30185808) (PMCID:PMC6125344)
2016
Giardino, G. et al. (2016) Targeted next-generation sequencing revealed MYD88 deficiency in a child with chronic yersiniosis and granulomatous lymphadenitis. Journal of Allergy and Clinical Immunology, 137(5), 1591-1595.e4. (doi: 10.1016/j.jaci.2015.09.050) (PMID:26632527)
Giardino, G. et al. (2016) Novel STAT1 gain-of-function mutation and suppurative infections. Pediatric Allergy and Immunology, 27(2), pp. 220-223. (doi: 10.1111/pai.12496) (PMID:26467763)
2015
Somma, D. et al. (2015) CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA Induced by IL-17. Journal of Immunology, 194(7), pp. 3286-3294. (doi: 10.4049/jimmunol.1401589) (PMID:25710910) (PMCID:PMC4369453)
Articles
Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)
Somma, D., Kok, F. O., Kerrigan, D., Wells, C. A. and Carmody, R. J. (2021) Defining the role of nuclear factor NF-κB p105 subunit in human macrophage by transcriptomic analysis of NFKB1 knockout THP-1 cells. Frontiers in Immunology, 12, 669906. (doi: 10.3389/fimmu.2021.669906) (PMCID:PMC8548695)
MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)
Mitxitorena, I., Somma, D., Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E. L., Kiely, P. A., Walden, H. , Keeshan, K. and Carmody, R. J. (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry, 295(33), pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113) (PMID:32587091) (PMCID:PMC7450122)
Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)
Collins, P. E., Somma, D., Kerrigan, D., Herrington, F., Keeshan, K. R. , Nibbs, R. J.B. and Carmody, R. J. (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 25828-25838. (doi: 10.1073/pnas.1900408116) (PMID:31772019) (PMCID:PMC6926074)
Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi: 10.1093/nar/gkz873) (PMID:31598684) (PMCID:PMC6868378)
Barra, G. et al. (2018) Sphingosine Kinases promote IL-17 expression in human T lymphocytes. Scientific Reports, 8, 13233. (doi: 10.1038/s41598-018-31666-1) (PMID:30185808) (PMCID:PMC6125344)
Giardino, G. et al. (2016) Targeted next-generation sequencing revealed MYD88 deficiency in a child with chronic yersiniosis and granulomatous lymphadenitis. Journal of Allergy and Clinical Immunology, 137(5), 1591-1595.e4. (doi: 10.1016/j.jaci.2015.09.050) (PMID:26632527)
Giardino, G. et al. (2016) Novel STAT1 gain-of-function mutation and suppurative infections. Pediatric Allergy and Immunology, 27(2), pp. 220-223. (doi: 10.1111/pai.12496) (PMID:26467763)
Somma, D. et al. (2015) CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA Induced by IL-17. Journal of Immunology, 194(7), pp. 3286-3294. (doi: 10.4049/jimmunol.1401589) (PMID:25710910) (PMCID:PMC4369453)