Professor Mariola Kurowska-Stolarska

Professor of Immune Pathology and Homeostasis (Immunology & Infection)

telephone: 01413306085
email: Mariola.Kurowska-Stolarska@glasgow.ac.uk

RB423 Level B4, Iii - Gbrc, University Place, Glasgow G12 8TA

ORCID iD https://orcid.org/0000-0003-2124-7777

Research interests

I have two main research interests:

(i) Understanding mechanisms of synovial joint immune-homeostasis and the role of synovial tissue macrophages in this process.

(ii) Understanding post-transcriptional mechanisms regulating macrophage and dendritic cell-biology.

(i) Understanding the mechanisms of synovial joint immune-homeostasis and the role of synovial tissue macrophages in this process

‌‌Synovial joints link the musculoskeletal system, and synovial fluid lubricates the joint and nourishes avascular cartilage. Macrophages are constitutively resident in the healthy human synovium. During inflammatory arthritis, there is an influx of monocytes into the synovium where they differentiate into pro-inflammatory macrophages. During disease remission, the macrophage numbers decrease but the subpopulation in the lining layer of the synovium persists.

Using multicolour flow-cytometry and single-cell RNA sequencing, we found that human synovial tissue macrophages are heterogeneous (figure). There are different macrophage clusters comparing heathy, arthritis and remission synovium. My lab tests the function of these macrophage clusters. We are also interested in establishing their ontogeny, how the clusters change during synovitis, and importantly, their role in resolution of disease and joint homeostasis. This work is done within the Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE)structure.

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(ii) Understanding post-transcriptional mechanisms regulating macrophage and dendritic cell-biology.

Dendritic cells (DC) are pivotal in directing the immune system towards a protective response against pathogens while maintaining tolerance to self-molecules. Disregulated DC activation can lead to pathogenic extremes e.g. immuno-suppression and autoimmunity. Macrophageseliminate pathogens and mediate tissue repair. However, aberrant activations can lead to chronic inflammation and pathogenic remodelling. Activation of both cell types needs to be tightly controlled.

We are interested in the epigenetic regulation of DC and macrophage responses by microRNAs. We found that microRNA34a regulates DC-driven activation of antigen-specific effector-T-cells by controlling the Axl/GAS6 immunosuppressive pathway. We also found that microRNA155 is a homeostatic master-switch determining the relative dynamics of inflammatory and repair responses in macrophages. High miR155 levels, by inhibiting SHIP1, lead to chronic pro-inflammatory activation of macrophages and synovial inflammation; while low levels of miR155, by removing the inhibitory control of LXRalpha, lead to liver steatosis and lung fibrosis.

Our current research focuses on therapeutic translation of these discoveries. Find out more about my lab group.

Publications

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Number of items: 102.

2022

van Gijsel-Bonnello, M. et al. (2022) Salt Inducible Kinase 2 regulates fibrosis during bleomycin-induced lung injury. Journal of Biological Chemistry, 298(12), 102644. (doi: 10.1016/j.jbc.2022.102644) (PMID:36309093)

Farina, L. et al. (2022) Pro nerve growth factor and its receptor p75NTR activate inflammatory responses in synovial fibroblasts: a novel targetable mechanism in arthritis. Frontiers in Immunology, 13, 818630. (doi: 10.3389/fimmu.2022.818630) (PMID:35309353) (PMCID:PMC8931659)

Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)

Micheroli, R. et al. (2022) Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis. RMD Open, 8(1), e001949. (doi: 10.1136/rmdopen-2021-001949) (PMID:34987094) (PMCID:PMC8734041)

2021

Clayton, S. A. et al. (2021) Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48. Science Advances, 7(50), eabl5182. (doi: 10.1126/sciadv.abl5182) (PMID:34878835)

Akbar, M., MacDonald, L., Crowe, L. A.N., Carlberg, K., Kurowska-Stolarska, M. , Ståhl, P. L., Snelling, S. J.B., McInnes, I. B. and Millar, N. L. (2021) Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Annals of the Rheumatic Diseases, 80(11), pp. 1494-1497. (doi: 10.1136/annrheumdis-2021-220256) (PMID:34001518) (PMCID:PMC8522454)

MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)

Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788) (PMCID:PMC8058094)

Rayner, F. et al. (2021) BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study. BMC Rheumatology, 5, 22. (doi: 10.1186/s41927-021-00194-3) (PMID:34275488) (PMCID:PMC8286860)

2020

Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)

Ramilowski, J. A. et al. (2020) Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Research, 30(7), pp. 1060-1072. (doi: 10.1101/gr.254219.119) (PMID:32718982) (PMCID:PMC7397864)

2019

Finlay, S. et al. (2019) Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts. 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA, 08-13 Nov 2019.

McShane, L. , Tabas, I., Lemke, G., Kurowska-Stolarska, M. and Maffia, P. (2019) TAM receptors in cardiovascular disease. Cardiovascular Research, 115(5), pp. 1286-1295. (doi: 10.1093/cvr/cvz100) (PMID:30980657) (PMCID:PMC6587925)

Elmesmari, A. et al. (2019) Do Functional Interactions Between Macrophages and Synovial Fibroblasts Drive Synovial Pathology or Resolution of Inflammation? European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Finlay, S. et al. (2019) Single-cell Transcriptomic and Functional Analyses Reveal Novel Heterogeneity in Pathogenic Pathways Mediated by Human Synovial Tissue Macrophages. European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Goncalves-Alves, E. et al. (2019) MicroRNA-155 controls T helper cell activation during viral infection. Frontiers in Immunology, 10, 1367. (doi: 10.3389/fimmu.2019.01367) (PMID:31275315) (PMCID:PMC6593301)

2018

Alivernini, S. et al. (2018) Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation. 2018 ACR/ARHP Annual Meeting, Chicago, IL, 19-24 Oct 2018. (Unpublished)

Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska-Stolarska, M. and McInnes, I.B. (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology, 193(1), pp. 13-23. (doi: 10.1111/cei.13098) (PMID:29315512) (PMCID:PMC6038003)

Elmesmari, A., Alivernini, S., Tolusso, B., Bui, L., Vaughan, D. , Federico, F., Gremese, E., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Stolarska Synovial Tissue CD1c+ Dendritic Cells in Rheumatoid Arthritis Express High Levels of the Epigenetic Regulator of Inflammation, Microrna-155 and Inflammatory Cytokines. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Finlay, S., Alivernini, S., Elmesmari, A., Tolusso, B., Ferraccioli, G., Gremese, E., Petricca, L., McInnes, I. B. , Kurowska-Stolarska, M. and Filer, A. (2018) Activation of Mertk+cd206+ Subpopulation of Human Synovial Tissue-Resident Macrophages Limits Inflammatory Response. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Cooles, F. A.H., Anderson, A. E., Skelton, A., Pratt, A. G., Kurowska-Stolarska, M. S. , McInnes, I. , Hilkens, C. M.U. and Isaacs, J. D. (2018) Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis. Frontiers in Immunology, 9, 755. (doi: 10.3389/fimmu.2018.00755) (PMID:29867920) (PMCID:PMC5968398)

Hecht, I. et al. (2018) ILDR2 is a novel B7-like protein that negatively regulates T cell responses. Journal of Immunology, 200(6), pp. 2025-2037. (doi: 10.4049/jimmunol.1700325) (PMID:29431694)

Shams, K., Kurowska-Stolarska, M. , Schütte, F., Burden, A. D., McKimmie, C. S. and Graham, G. J. (2018) MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Journal of Biological Chemistry, 293(8), pp. 3003-3012. (doi: 10.1074/jbc.M117.809780) (PMID:29279330) (PMCID:PMC5827444)

Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M. and Clark, A. R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi: 10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)

Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. Microphage Biology in the Single-Cell Era, Ghent, Belgium, 2018. (Unpublished)

2017

Kurowska-Stolarska, M. and Alivernini, S. (2017) Synovial tissue macrophages: friend or foe? RMD Open, 3(2), e000527. (doi: 10.1136/rmdopen-2017-000527) (PMID:29299338) (PMCID:PMC5729306)

Jaigrdar, S. A., Benson, R. A. , Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi: 10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)

Saferding, V. et al. (2017) MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. Journal of Autoimmunity, 82, pp. 74-84. (doi: 10.1016/j.jaut.2017.05.006) (PMID:28545737)

Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)

Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)

Elmesmari, A., Alivernini, S., Vaughan, D. , Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Characterisation of Synovium Tissues Macropahges. Rheumatology 2017, Birmingham, UK, 25-27 April 2017. (Unpublished)

Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)

Chen, L. et al. (2017) miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. Annals of the Rheumatic Diseases, 76(3), pp. 620-624. (doi: 10.1136/annrheumdis-2016-210175) (PMID:28039186)

2016

Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)

Huesa, C. et al. (2016) Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology. Annals of the Rheumatic Diseases, 75(11), pp. 1989-1997. (doi: 10.1136/annrheumdis-2015-208268) (PMID:26698846) (PMCID:PMC5099200)

Bolognini, D. et al. (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. Journal of Biological Chemistry, 291, pp. 18915-18931. (doi: 10.1074/jbc.M116.736157) (PMID:27385588) (PMCID:PMC5009265)

Lavery, C. A., Kurowska-Stolarska, M. , Holmes, W. , Donnelly, I., Caslake, M., Collier, A., Baker, A. H. and Miller, A. M. (2016) miR-34a-/- mice are susceptible to diet-induced obesity. Obesity, 24(8), pp. 1741-1751. (doi: 10.1002/oby.21561) (PMID:27377585) (PMCID:PMC4979678)

Komai-Koma, M., Wang, E., Kurowska-Stolarska, M. , Li, D., McSharry, C. and Xu, D. (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi: 10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)

Alivernini, S. et al. (2016) MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nature Communications, 7, 12970. (doi: 10.1038/ncomms12970) (PMID:27671860) (PMCID:PMC5052655)

Elmesmari, A., Alivernini, S., McInnes, I. B. and Kurowska-Stolarska, M. (2016) Targeting miR-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production. Scottish Society of Rheumatology Meeting 2016, Dundee, 2016. (Unpublished)

2015

Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)

2014

Li, D. et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. Journal of Allergy and Clinical Immunology, 134(6), 1422-1432.e11. (doi: 10.1016/j.jaci.2014.05.011) (PMID:24985397) (PMCID:PMC4258609)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)

Elmesmari, A., Pushparaj, P. N., Reilly, J., Kerr, S., Kurowska-Stolarska, M. and McInnes, I. B. (2014) Role of SPHKs and S1PRs in Rheumatoid Arthritis. 3rd European Congress of Immunology (ECI 2012), Glasgow, UK, 5-8 Sept 2012. (Unpublished)

Holla, S., Kurowska-Stolarska, M. , Bayry, J. and Balaji, K. (2014) Selective inhibition of IFNG-induced autophagy by Mir155- and Mir31-responsive WNT5A and SHH signaling. Autophagy, 10(2), pp. 311-330. (doi: 10.4161/auto.27225)

2013

Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi: 10.1136/annrheumdis-2012-202872) (PMID:23434566)

Frleta, M., Rainey, A.-A., Gilchrist, D.S., Crawford, L., Baxter, D., Kurowska-Stolarska, M. and McInnes, I.B. (2013) Mir-27b as Biomarker and Regulator of IL-6R Pathway in Resistant Rheumatoid Arthritis Monocyte. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S1035.

Millar, N.L. , Gilchrist, D.S., Kurowska-Stolarska, M. , Murrell, G.A.C. and McInnes, I. B. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: EULAR 2013: Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June 2013, p. 140.

Millar, N. L. , Gilchrist, D. S., Kurowska-Stolarska, M. , Murrell, G. A.C. and McInnes, I. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S405.

Miller, A. M., Gilchrist, D. S., Nijjar, J., Araldi, E., Ramirez, C. M., Lavery, C. A., Fernández-Hernando, C., McInnes, I. B. and Kurowska-Stolarska, M. (2013) MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE, 8(8), e72324. (doi: 10.1371/journal.pone.0072324) (PMID:23991091) (PMCID:PMC3749101)

Rainey, A.-A., Gilchrist, D. S., Tange, C. E., Frleta, M., Crawford, L., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-125a: A novel regulator of IL-6 and TLR driven pathways in RA pathogenesis. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S404.

Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.

2012

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. , Rainey, A.-A., Pich, D., McInnes, I.B. , Hammerschmidt, W., O'Neill, L.A.J. and Masters, S.L. (2012) Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1 production. Journal of Immunology, 189(8), pp. 3795-3799. (doi: 10.4049/jimmunol.1200312) (PMID:22984081)

Statache, G., Rainey, A.-A., Masters, S., Balanescu, A., McInnes, I. B. and Kurowska-Stolarska, M. (2012) Regulation of microrna 223 expression in a gouty arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S811. (doi: 10.1002/art.37735)

Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)

Elmesmari, A., Pushparaj, P., Reilly, J., Kerr, S., Kurowska-Stolarska, M. and McInnes, I. (2012) The role of SPHKs and SIPRs in rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 260. (doi: 10.1111/imm.12002)

Statache, G., Rainey, A., Crawford, L., Masters, S., Balanescu, A., McInnes, I. and Kurowska-Stolarska, M. (2012) Regulation of microRNA 223 expression in a gouty arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 227. (doi: 10.1111/imm.12002)

Ghorpade, D. S., Leyland, R., Kurowska-Stolarska, M. , Patil, S. A. and Balaji, K. N. (2012) MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Molecular and Cellular Biology, 32(12), pp. 2239-2253. (doi: 10.1128/MCB.06597-11)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. , Rainey, A., Pitch, D., Hammerschmidt, W., O’Neill, L. and Masters, S. (2012) miR-223 targets IL-1β production and is decreased in synovial fluid monocytes from arthritis patients. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, 12-15 May 2012, pp. 9-10. (doi: 10.1111/j.1445-5994.2012.02761.x)

Baxter, D., McInnes, I.B. and Kurowska-Stolarska, M. (2012) Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunology and Cell Biology, 90(3), pp. 288-292. (doi: 10.1038/icb.2011.114) (PMID:22249200)

Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)

Kurowska-Stolarska, M. , Hasoo, M., Gilchrist, D. G., Ruzicska, E., Asquith, D., Welsh, D., Crawford, L., Hirani, N., McInnes, I. B. and McSharry, C. (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)

2011

Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)

Zaiss, M. M. et al. (2011) IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-α–mediated bone loss. Journal of Immunology, 186(11), pp. 6097-6105. (doi: 10.4049/jimmunol.1003487) (PMID:21515798)

Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.

2010

Stolarski, B., Kurowska-Stolarska, M. , Kewin, P., Xu, D. and Liew, F. Y. (2010) IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation. Journal of Immunology, 185(6), pp. 3472-3480. (doi: 10.4049/jimmunol.1000730)

Xu, D. et al. (2010) IL-33 exacerbates autoantibody-induced arthritis. Journal of Immunology, 184(5), pp. 2620-2626. (doi: 10.4049/jimmunol.0902685) (PMID:20139274)

Kurowska-Stolarska, M. , Hueber, A., Stolarski, B. and McInnes, I. B. (2010) Interleukin-33: a novel mediator with a role in distinct disease pathologies. Journal of Internal Medicine, 269(1), pp. 29-35. (doi: 10.1111/j.1365-2796.2010.02316.x) (PMID:21158975)

Kurowska-Stolarska, M. , Ballantine, L., Stolarski, B., Hunter, J., Hueber, A., Gracie, J.A., Liew, F. Y. and McInnes, I. B. (2010) miR-155 and miR-34a regulate proinflammatory cytokine production by human monocytes. In: European Workshop for Rheumatology Research, Bamberg, Germany, 4-7 Mar 2010, A30-A30. (doi: 10.1136/ard.2010.129619g)

2009

Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)

Kurowska-Stolarska, M. et al. (2009) Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast-dependent osteoclastogenesis. Arthritis and Rheumatism, 60(12), pp. 3663-3675. (doi: 10.1002/art.25001)

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

2008

Kurowska-Stolarska, M. et al. (2008) IL-33 induces antigen-specific IL-5⁺ T cells and promotes allergic-induced airway inflammation independent of IL-4. Journal of Immunology, 181(7), pp. 4780-4790.

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Kurowska-Stolarska, M. S. , Kewin, P., Stolarski, B., Fraser, A., Xu, D., McInnes, I. and Liew, F. Y. (2008) A role of IL-33 in bone turnover. In: 72nd Annual Scientific Meeting of the American College of Rheumatology and the 43rd Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Francisco CA, USA, 24-29 Oct 2008, S895.

Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2008) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased local Th2 cytokine and chemokine production. In: Scottish Thoracic Society Meeting, Stirling, UK, 26 Oct 2007, p. 50. (doi: 10.1258/rsmsmj.53.2.48)

2007

Ospelt, C., Kurowska-Stolarska, M. , Neidhart, M., Michel, B. A., Gay, R. E., Laufer, S. and Gay, S. (2007) The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. Annals of the Rheumatic Diseases, 67(4), pp. 524-529. (doi: 10.1136/ard.2007.071589)

Kewin, P., Kurowska-Stolarska, M. , Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2007) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased ST2 dependent local Th2 cytokine and chemokine production. In: Winter Meeting of the British-Thoracic-Society, London, UK, 05-07 Dec 2007, A1.

2005

Distler, J. H.W., Jüngel, A., Kurowska-Stolarska, M. , Michel, B. A., Gay, R. E., Gay, S. and Distler, O. (2005) Nucleofection: a new, highly efficient transfection method for primary human keratinocytes. Experimental Dermatology, 14(4), pp. 315-20. (doi: 10.1111/j.0906-6705.2005.00276.x)

Kurowska-Stolarska, M. et al. (2005) The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis. In: 25th European Workshop for Rheumatology Research, Glasgow, UK, 24-27 Feb 2005, P48. (doi: 10.1186/ar1569)

Kurowska-Stolarska, M. , Neidhart, M., Michel, B.A., Simmen, B.R. and Gay, R.E. (2005) Licofelone, a COX/5-LOX inhibitor blocks chemoattraction of Th1 cells by down regulation of CXCR3 ligands in synovial fibroblasts. In: 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, USA, 12-17 Nov 2005, S568.

2004

Ospelt, C. et al. (2004) Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways. In: Sixth International Symposium on Advances in Targeted Therapies, Venice, Italy, 28 Apr - 2 May 2004, ii90-ii91. (doi: 10.1136/ard.2004.028324)

Kurowska-Stolarska, M. , Distler, J., Pap, T., Jungel, A., Michel, B.A., Simmen, B.R., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of differentiation-2 (Id-2) induced by hypoxia promotes bone de radation in rheumatoid arthritis (RA). In: 68th Annual Scientific Meeting of the American College of Rheumatology/39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S655.

Jüngel, A. et al. (2004) Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis and Rheumatism, 50(5), pp. 1468-1476. (doi: 10.1002/art.20218)

Distler, J. H.W., Wenger, R. H., Gassmann, M., Kurowska-Stolarska, M. , Hirth, A., Gay, S. and Distler, O. (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis and Rheumatism, 50(1), pp. 10-23. (doi: 10.1002/art.11425)

Kurowska-Stolarska, M. , Distler, J., Pap, T., Hirth, A., Moritz, W., Michel, B.A., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of helix-loop-helix transcription factor ID-2 triggered by hypoxia and proinflammatory cytokines promotes the activated phenotype of synovial fibroblasts facilitating bone degradation. In: 5th Annual Congress of the European League Against Rheumatism (EULAR 2004), Berlin, Germany, 9-12 June 2004, p. 79.

Ospelt, C., Kurowska-Stolarska, M. , Neidhart, M., Michel, B.A., Simmen, B.R., Gay, R.E. and Gay, S. (2004) Licofelone, a cylooxygenase/5-lipoxygenase inhibitor reduces expression of IP-10 in rheumatoid arthritis synovial fibroblasts. In: 68th Annual Scientific Meeting of the American College of Rheumatology / 39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S570.

2003

Distler, J. H. W., Hirth, A., Kurowska-Stolarska, M. , Gay, R. E., Gay, S. and Distler, O. (2003) Angiogenic and angiostatic factors in the molecular control of angiogenesis. Quarterly Journal of Nuclear Medicine, 47(3), pp. 149-61.

Kurowska-Stolarska, M. , Distler, J., Moritz, W., Marti, H., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2003) The expression of inhibitor of differentiation-2 (Id-2) is induced by hypoxia in synovial fibroblasts independently of HIF-1a. In: 67th Annual Scientific Meeting of the American College of Rheumatology/38th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Orlando, FL, USA, 23-28 Oct 2003, S146.

Kurowska-Stolarska, M. , Distler, O., Rudnicka, W., Distler, J., Gay, R.E., Maslinski, W. and Gay, S. (2003) IL-15 and its role in rheumatoid arthritis. In: 3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit, Miyakazi, Japan, 14-17 Sept 2003, p. 139. (doi: 10.1186/ar940)

2002

Kurowska-Stolarska, M. , Rudnicka, W., Janicka, I., Chorazy, M., Kowalczewski, J., Ziolkowska, M., Ferrari-Lacraz, S., Ferrari-Lacraz, S., Strom, T.B. and Maslinski, W. (2002) Endogenous IL-15 in autocrine fashion enhances rheumatoid arthritis fibroblast-like synoviocytes proliferation and resistance to apoptosis. In: 66th Annual Scientific Meeting of the American College of Rheumatology/37th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, New Orleans, LA, USA, 24-29 Oct 2002, S554.

Kurowska-Stolarska, M. , Rudnicka, W., Kontny, E., Janicka, I., Chorazy, M., Kowalczewski, J., Ziółkowska, M., Ferrari-Lacraz, S., Strom, T. B. and Maśliński, W. (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. Journal of Immunology, 169(4), pp. 1760-7. (doi: 10.4049/jimmunol.169.4.1760)

Ziolkowska, M. et al. (2002) High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis and Rheumatism, 46(7), pp. 1744-1753. (doi: 10.1002/art.10388)

Kurowska, M. , Rudnicka, W., Maślińska, D. and Maśliński, W. (2002) Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Annals of the New York Academy of Sciences, 966, pp. 441-445. (doi: 10.1111/j.1749-6632.2002.tb04245.x)

2000

Kontny, E., Szczepańska, K., Kowalczewski, J., Kurowska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (2000) The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 43(10), pp. 2169-2177.

Kontny, E., Kurowska, M. , Szczepańska, K. and Maśliński, W. (2000) Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. Journal of Leukocyte Biology, 67(2), pp. 249-258.

1999

Kontny, E., Grabowska, A., Kowalczewski, J., Kurowska-Stolarska, M. , Janicka, I., Marcinkiewicz, J. and Maśliński, W. (1999) Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 42(12), pp. 2552-60. (doi: 10.1002/1529-0131(199912)42:12<2552::AID-ANR7>3.0.CO;2-V)

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