Ms Lavinia Coletto

  • Clinical Research Fellow (Immunology & Infection)

Research interests

As a rheumatologist, my primary concern is the management of patients with chronic inflammatory arthritis, such as rheumatoid arthritis and psoriatic arthritis. To address the unmet clinical needs encountered at the patient's bedside, I perform minimally invasive ultrasound-guided synovial tissue biopsies. These biopsies allow me to study the primary target of the disease—the synovial tissue—at the bench.

A figure with three images showing Dr Coletto's research interests

My current research focuses on:  
 

  • Mechanisms of transition from psoriasis to psoriatic arthritis 

Although musculoskeletal involvement in psoriatic disease is preceded by skin involvement in most patients, we are currently unable to predict and prevent this transition, which ends in debilitating disease. The aim of our research is to identify the mechanisms and biomarkers of the transition from Psoriasis to Psoriatic Arthritis by assessing the immunological interplay between skin, blood and synovial tissue cells using high throughput technologies.

 

  • Characterization of the tenosynovium in rheumatoid arthritis and in the preclinical phases of the disease.

Tenosynovial inflammation has been identified as a preclinical feature associated with an increased risk of developing clinical rheumatoid arthritis. However, how tenosynovial inflammation is related to the development of synovitis and RA is unknown. A better understanding of the mechanisms of the transition from pre-RA to RA has the potential to provide therapeutic targets that may prevent the onset of the disease.  Our aim is to use minimally invasive US-guided tenosynovial tissue biopsy and single-cell omics and functional studies to characterize tenosynovium and synovium at pre-clinical stages to identify the potential mechanisms that initiate RA.

 

 

Links

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018
Number of items: 17.

2024

Coletto, L. A., Marino, V., Rizzo, C., Bruno, D., Caporali, R., Gremese, E., D'Agostino, M. A. and Alivernini, S. (2024) Intensive training programme for ultrasound-guided minimally invasive synovial tissue biopsy on knees and wrists in different phases of inflammation. RMD Open, 10(1), e003705. (doi: 10.1136/rmdopen-2023-003705) (PMID:38351051) (PMCID:PMC10868172)

2023

Coletto, L. A., Rizzo, C., Guggino, G., Caporali, R., Alivernini, S. and Antonietta D’Agostino, M. (2023) The role of neutrophils in Spondyloarthritis: a journey across the spectrum of disease manifestations. International Journal of Molecular Sciences, 24(4), 4108. (doi: 10.3390/ijms24044108) (PMID:36835520) (PMCID:PMC9959122)

Coletto, L. (2023) Minimally invasive ultrasound-guided procedure to identify and retrieve tenosynovial tissue from hands of pre-clinical, active and remission Rheumatoid Arthritis. European Synovitis Study Group at EULAR, Milan, Italy, 2023.

2022

Cambria, C. et al. (2022) Synovial fluid-derived extracellular vesicles of patients with arthritides contribute to hippocampal synaptic dysfunctions and increase with mood disorders severity in humans. Cells, 11(15), 2276. (doi: 10.3390/cells11152276) (PMID:35892573) (PMCID:PMC9331474)

Tani, C. et al. (2022) Impact of low-dose acetylsalicylic acid on pregnancy outcome in systemic lupus erythematosus: results from a multicentre study. Lupus Science and Medicine, 9(1), e000714. (doi: 10.1136/lupus-2022-000714)

Coletto, L. A., Gerosa, M., Valentini, M., Cimaz, R., Caporali, R., Meroni, P. L. and Chighizola, C. B. (2022) Myocardial involvement in anti-phospholipid syndrome: Beyond acute myocardial infarction. Autoimmunity Reviews, 21(3), 102990. (doi: 10.1016/j.autrev.2021.102990) (PMID:34740852)

2021

Crotti, C. et al. (2021) Tumor induced osteomalacia: A single center experience on 17 patients. Bone, 152, 116077. (doi: 10.1016/j.bone.2021.116077) (PMID:34175499)

Ingegnoli, F., Coletto, L., Scotti, I., Compagnoni, R., Randelli, P. S. and Caporali, R. (2021) The crucial questions on synovial biopsy: when, why, who, what, where, and how? Frontiers in Medicine, 8, 705382. (doi: 10.3389/fmed.2021.705382) (PMID:34422862) (PMCID:PMC8377390)

Gabriella Raimondo, M., Biggioggero, M., Coletto, L. A., Ramming, A., Caporali, R. and Giulio Favalli, E. (2021) Clinical pharmacology of filgotinib in the treatment of rheumatoid arthritis: current insights. Expert Review of Clinical Pharmacology, 14(6), pp. 661-670. (doi: 10.1080/17512433.2021.1913050) (PMID:33847204)

Randelli, P., Coletto, L. A., Menon, A. and Caporali, R. (2021) Correspondence on ‘Non-surgical and surgical treatments for rotator cuff disease: a pragmatic randomised clinical trial with 2-year follow-up after initial rehabilitation’. Annals of the Rheumatic Diseases, 82(4), e102. (doi: 10.1136/annrheumdis-2020-219751) (PMID:33536162)

Chighizola, C. B. et al. (2021) Psychosocial burden in young patients with primary anti-phospholipid syndrome: an Italian nationwide survey (The AQUEOUS study). Clinical and Experimental Rheumatology, 39(5), pp. 938-946. (doi: 10.55563/clinexprheumatol/2b73dn) (PMID:32940209)

2020

Ingegnoli, F., Buoli, M., Antonucci, F., Coletto, L. A., Esposito, C. M. and Caporali, R. (2020) The link between autonomic nervous system and rheumatoid arthritis: from bench to bedside. Frontiers in Medicine, 7, 589079. (doi: 10.3389/fmed.2020.589079) (PMID:33365319) (PMCID:PMC7750536)

Coletto, L. A., Giulio Favalli, E. and Caporali, R. (2020) Psoriasis and psoriatic arthritis: How to manage immunosuppressants in COVID ‐19 days. Dermatologic Therapy, 33(4), e13415. (doi: 10.1111/dth.13415) (PMID:32291828) (PMCID:PMC7235523)

2019

Ramirez, G. A., Canti, V., Moiola, L., Magnoni, M., Rovere‐Querini, P., Coletto, L. A., Dagna, L., Manfredi, A. A. and Bozzolo, E. P. (2019) Performance of SLE responder index and lupus low disease activity state in real life: A prospective cohort study. International Journal of Rheumatic Diseases, 22(9), pp. 1752-1761. (doi: 10.1111/1756-185x.13663) (PMID:31379114)

2018

Ramirez, G. A. et al. (2018) The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function. Journal of Neuroimmunology, 325, pp. 43-53. (doi: 10.1016/j.jneuroim.2018.10.010) (PMID:30384327)

Canti, V. et al. (2018) Antiphosphatidylserine/prothrombin antibodies in Antiphospholipid Syndrome with intrauterine growth restriction and preeclampsia. Journal of Rheumatology, 45(9), pp. 1263-1272. (doi: 10.3899/jrheum.170751) (PMID:30008452)

Ramirez, G., Coletto, L., Sciorati, C., Bozzolo, E., Manunta, P., Rovere-Querini, P. and Manfredi, A. (2018) Ion channels and transporters in inflammation: special focus on TRP channels and TRPC6. Cells, 7(7), p. 70. (doi: 10.3390/cells7070070) (PMID:29973568) (PMCID:PMC6070975)

This list was generated on Mon Apr 15 21:02:47 2024 BST.
Number of items: 17.

Articles

Coletto, L. A., Marino, V., Rizzo, C., Bruno, D., Caporali, R., Gremese, E., D'Agostino, M. A. and Alivernini, S. (2024) Intensive training programme for ultrasound-guided minimally invasive synovial tissue biopsy on knees and wrists in different phases of inflammation. RMD Open, 10(1), e003705. (doi: 10.1136/rmdopen-2023-003705) (PMID:38351051) (PMCID:PMC10868172)

Coletto, L. A., Rizzo, C., Guggino, G., Caporali, R., Alivernini, S. and Antonietta D’Agostino, M. (2023) The role of neutrophils in Spondyloarthritis: a journey across the spectrum of disease manifestations. International Journal of Molecular Sciences, 24(4), 4108. (doi: 10.3390/ijms24044108) (PMID:36835520) (PMCID:PMC9959122)

Cambria, C. et al. (2022) Synovial fluid-derived extracellular vesicles of patients with arthritides contribute to hippocampal synaptic dysfunctions and increase with mood disorders severity in humans. Cells, 11(15), 2276. (doi: 10.3390/cells11152276) (PMID:35892573) (PMCID:PMC9331474)

Tani, C. et al. (2022) Impact of low-dose acetylsalicylic acid on pregnancy outcome in systemic lupus erythematosus: results from a multicentre study. Lupus Science and Medicine, 9(1), e000714. (doi: 10.1136/lupus-2022-000714)

Coletto, L. A., Gerosa, M., Valentini, M., Cimaz, R., Caporali, R., Meroni, P. L. and Chighizola, C. B. (2022) Myocardial involvement in anti-phospholipid syndrome: Beyond acute myocardial infarction. Autoimmunity Reviews, 21(3), 102990. (doi: 10.1016/j.autrev.2021.102990) (PMID:34740852)

Crotti, C. et al. (2021) Tumor induced osteomalacia: A single center experience on 17 patients. Bone, 152, 116077. (doi: 10.1016/j.bone.2021.116077) (PMID:34175499)

Ingegnoli, F., Coletto, L., Scotti, I., Compagnoni, R., Randelli, P. S. and Caporali, R. (2021) The crucial questions on synovial biopsy: when, why, who, what, where, and how? Frontiers in Medicine, 8, 705382. (doi: 10.3389/fmed.2021.705382) (PMID:34422862) (PMCID:PMC8377390)

Gabriella Raimondo, M., Biggioggero, M., Coletto, L. A., Ramming, A., Caporali, R. and Giulio Favalli, E. (2021) Clinical pharmacology of filgotinib in the treatment of rheumatoid arthritis: current insights. Expert Review of Clinical Pharmacology, 14(6), pp. 661-670. (doi: 10.1080/17512433.2021.1913050) (PMID:33847204)

Randelli, P., Coletto, L. A., Menon, A. and Caporali, R. (2021) Correspondence on ‘Non-surgical and surgical treatments for rotator cuff disease: a pragmatic randomised clinical trial with 2-year follow-up after initial rehabilitation’. Annals of the Rheumatic Diseases, 82(4), e102. (doi: 10.1136/annrheumdis-2020-219751) (PMID:33536162)

Chighizola, C. B. et al. (2021) Psychosocial burden in young patients with primary anti-phospholipid syndrome: an Italian nationwide survey (The AQUEOUS study). Clinical and Experimental Rheumatology, 39(5), pp. 938-946. (doi: 10.55563/clinexprheumatol/2b73dn) (PMID:32940209)

Ingegnoli, F., Buoli, M., Antonucci, F., Coletto, L. A., Esposito, C. M. and Caporali, R. (2020) The link between autonomic nervous system and rheumatoid arthritis: from bench to bedside. Frontiers in Medicine, 7, 589079. (doi: 10.3389/fmed.2020.589079) (PMID:33365319) (PMCID:PMC7750536)

Coletto, L. A., Giulio Favalli, E. and Caporali, R. (2020) Psoriasis and psoriatic arthritis: How to manage immunosuppressants in COVID ‐19 days. Dermatologic Therapy, 33(4), e13415. (doi: 10.1111/dth.13415) (PMID:32291828) (PMCID:PMC7235523)

Ramirez, G. A., Canti, V., Moiola, L., Magnoni, M., Rovere‐Querini, P., Coletto, L. A., Dagna, L., Manfredi, A. A. and Bozzolo, E. P. (2019) Performance of SLE responder index and lupus low disease activity state in real life: A prospective cohort study. International Journal of Rheumatic Diseases, 22(9), pp. 1752-1761. (doi: 10.1111/1756-185x.13663) (PMID:31379114)

Ramirez, G. A. et al. (2018) The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function. Journal of Neuroimmunology, 325, pp. 43-53. (doi: 10.1016/j.jneuroim.2018.10.010) (PMID:30384327)

Canti, V. et al. (2018) Antiphosphatidylserine/prothrombin antibodies in Antiphospholipid Syndrome with intrauterine growth restriction and preeclampsia. Journal of Rheumatology, 45(9), pp. 1263-1272. (doi: 10.3899/jrheum.170751) (PMID:30008452)

Ramirez, G., Coletto, L., Sciorati, C., Bozzolo, E., Manunta, P., Rovere-Querini, P. and Manfredi, A. (2018) Ion channels and transporters in inflammation: special focus on TRP channels and TRPC6. Cells, 7(7), p. 70. (doi: 10.3390/cells7070070) (PMID:29973568) (PMCID:PMC6070975)

Conference or Workshop Item

Coletto, L. (2023) Minimally invasive ultrasound-guided procedure to identify and retrieve tenosynovial tissue from hands of pre-clinical, active and remission Rheumatoid Arthritis. European Synovitis Study Group at EULAR, Milan, Italy, 2023.

This list was generated on Mon Apr 15 21:02:47 2024 BST.