Sugar may inhibit mosquito ability to transmit arboviruses
Published: 6 September 2021
Sugar feeding prior to having an infected blood meal could protect a mosquito’s ability to get infected and transmit arboviruses, according to a new study led by our Centre for Virus Research.
Sugar feeding prior to having an infected blood meal could protect a mosquito’s ability to get infected and transmit arboviruses such as Zika, dengue and chikungunya, according to a new study led by our Centre for Virus Research (CVR).
The research, published in PLOS Pathogens, showed that the Aedes aegypti species of mosquito, an arbovirus vector, had enhanced immunity in the gut after feeding on sugar, which in turn protected females of the species against viral infection.
The study findings are the result of a significant challenge to better understand how nutrition influences immunity and resistance to infection in a relevant species such as the mosquito.
Male and female adult mosquitoes feed on plant nectar and sap to get carbohydrates for their energy reserves. In addition, mosquito females require a blood meal to reproduce.
For this reason, they can act as vectors of numerous pathogens, such as the arboviruses like Zika, dengue and chikungunya, which constitute a substantial worldwide public health burden.
However, the influence of sugar on mosquito immunity and their ability to transmit viruses had not been explored - until now.
Since Aedes aegypti female mosquitoes almost exclusively feed on blood in some natural settings, the findings suggest that a lack of sugar intake could increase the spread of mosquito-borne arboviral diseases, and highlights a possible explanation for high susceptibility and transmission of arboviruses by this mosquito species.
Dr Emilie Pondeville, Molecular Entomologist at the CVR, said: “This study is important because we’ve been able to show that sugar feeding by these mosquitos blocks an initial infection of an arbovirus and lowers infection prevalence and intensity, thereby decreasing the potential of female mosquitoes to transmit these viruses further.
“Overall, our findings uncover a crucial role of sugar feeding in mosquito antiviral immunity, which in turn decreases the potential for spread of these arboviruses, which pose a significant threat to people.
“In future, this could inform the development and application of vector control strategies such as sugar baits, aimed at reducing arbovirus transmission.”
Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti
- Floriane Almire, Selim Terhzaz, Sandra Terry, Melanie McFarlane, Rommel J. Gestuveo, Agnieszka M. Szemiel, Margus Varjak, Alma McDonald, Alain Kohl, Emilie Pondeville
- PLoS Pathog 17(9): e1009870. https://doi.org/10.1371/journal.ppat.1009870
The study is funded by the Medical Research Council (MRC).
Image legend: Fig 3. Sucrose, glucose and fructose increase the expression levels of antiviral genes in the digestive tract of the female Ae. aegypti. (A) Schematic of experimental design. Females that did not have access to sucrose for 48 h were either not sugar fed or fed with 10 per cent sucrose, 10 per cent glucose or 10 per cent fructose solution. Digestive tracts were dissected 16h post sugar feeding time
First published: 6 September 2021