Dr Emilie Pondeville

  • Molecular Entomologist (Centre for Virus Research)

telephone: +44 (0) 141 330 5726
email: Emilie.Pondeville@glasgow.ac.uk

Research interests

CVR logo

I have a long-term research interest in better understanding mosquito biology and physiology. Female anautogenous mosquitoes need a blood meal from a vertebrate host to reproduce. Therefore they can act as vectors for numerous pathogens, e.g. arthropod-borne viruses (arboviruses) or parasites, responsible for both human and animal diseases.

To control the transmission of mosquito-borne diseases, diverse new control strategies such as transgenic mosquitoes are developed, either to reduce mosquito populations, either by rendering them refractory to pathogens. With this aim, a better knowledge of the reproductive biology and of immune responses of mosquito vectors is beneficial, as this could lead to the identification of new target genes for manipulating mosquitoes. It can also inform mosquito control release programs.

Access at the CVR to newly established insectaries, as well as modern transgenic facilities, provide an exciting opportunity to study in vivo mosquito-arbovirus interactions. In collaboration with other CVR groups my group is deciphering the molecular mechanisms involved in vector competence for arboviruses using genetic tools.

Our research aims to better understand the contribution of tissue-specific antiviral strategies in the mosquito, defence pathway crosstalk, as well as the communication between different mosquito tissues during a viral infection that leads to an integrated antiviral response. Moreover, we are focusing our research on vertical transmission of arboviruses and the molecular mechanisms involved as well as the function of this phenomenon in vectorial capacities of mosquitoes. In this context, we are also developing transgenics and genetic tools in Aedes mosquitoes, such as the Gal4/UAS system, to address gene function at the tissue level.


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • INFRAVEC-2
    European Commission
    2017 - 2021
     
  • Zikalliance
    European Commission
    2016 - 2019
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2008 | 2005
Number of items: 10.

2018

Adolfi, A., Pondeville, E., Lynd, A., Lycett, G. J. and Bourgouin, C. (2018) Multi-tissue GAL4-mediated gene expression in all Anopheles gambiae life stages using an endogenous polyubiquitin promoter. Insect Biochemistry and Molecular Biology, 96, pp. 1-9. (doi:10.1016/j.ibmb.2018.03.005) (PMID:29578046)

2017

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi:10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

2016

Pingen, M., Bryden, S. R., Pondeville, E., Schnettler, E., Kohl, A. , Merits, A., Fazakerley, J. K., Graham, G. J. and McKimmie, C. S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi:10.1016/j.immuni.2016.06.002) (PMID:27332734) (PMCID:PMC4920956)

Kohl, A. et al. (2016) Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements. Pathogens and Global Health, 110(4-5), pp. 164-172. (doi:10.1080/20477724.2016.1211475) (PMID:27677378) (PMCID:PMC5072118)

2015

Kean, J., Rainey, S., McFarlane, M., Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi:10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

2014

Carissimo, G. et al. (2014) Antiviral immunity of Anopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proceedings of the National Academy of Sciences of the United States of America, 112(2), E176-E185. (doi:10.1073/pnas.1412984112)

Pondeville, E., Puchot, N., Meredith, J. M., Lynd, A., Vernick, K. D., Lycett, G. J., Eggleston, P. and Bourgouin, C. (2014) Efficient ΦC31 integrase–mediated site-specific germline transformation of Anopheles gambiae. Nature Protocols, 9(7), pp. 1698-1712. (doi:10.1038/nprot.2014.117)

2013

Pondeville, E., David, J.-P., Guittard, E., Maria, A., Jacques, J.-C., Ranson, H., Bourgouin, C. and Dauphin-Villemant, C. (2013) Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis. PLoS ONE, 8(12), e79861. (doi:10.1371/journal.pone.0079861) (PMID:24324583) (PMCID:PMC3851169)

2008

Pondeville, E., Maria, A., Jacques, J.-C., Bourgouin, C. and Dauphin-Villemant, C. (2008) Anopheles gambiae males produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating. Proceedings of the National Academy of Sciences of the United States of America, 105(50), pp. 19631-19636. (doi:10.1073/pnas.0809264105)

2005

Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carré, C., Noselli, S. and Léopold, P. (2005) Antagonistic actions of ecdysone and insulins determine final size in drosophila. Science, 310(5748), pp. 667-670. (doi:10.1126/science.1119432) (PMID:16179433)

This list was generated on Sat Dec 15 22:14:12 2018 GMT.
Jump to: Articles
Number of items: 10.

Articles

Adolfi, A., Pondeville, E., Lynd, A., Lycett, G. J. and Bourgouin, C. (2018) Multi-tissue GAL4-mediated gene expression in all Anopheles gambiae life stages using an endogenous polyubiquitin promoter. Insect Biochemistry and Molecular Biology, 96, pp. 1-9. (doi:10.1016/j.ibmb.2018.03.005) (PMID:29578046)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi:10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Pingen, M., Bryden, S. R., Pondeville, E., Schnettler, E., Kohl, A. , Merits, A., Fazakerley, J. K., Graham, G. J. and McKimmie, C. S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi:10.1016/j.immuni.2016.06.002) (PMID:27332734) (PMCID:PMC4920956)

Kohl, A. et al. (2016) Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements. Pathogens and Global Health, 110(4-5), pp. 164-172. (doi:10.1080/20477724.2016.1211475) (PMID:27677378) (PMCID:PMC5072118)

Kean, J., Rainey, S., McFarlane, M., Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi:10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

Carissimo, G. et al. (2014) Antiviral immunity of Anopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proceedings of the National Academy of Sciences of the United States of America, 112(2), E176-E185. (doi:10.1073/pnas.1412984112)

Pondeville, E., Puchot, N., Meredith, J. M., Lynd, A., Vernick, K. D., Lycett, G. J., Eggleston, P. and Bourgouin, C. (2014) Efficient ΦC31 integrase–mediated site-specific germline transformation of Anopheles gambiae. Nature Protocols, 9(7), pp. 1698-1712. (doi:10.1038/nprot.2014.117)

Pondeville, E., David, J.-P., Guittard, E., Maria, A., Jacques, J.-C., Ranson, H., Bourgouin, C. and Dauphin-Villemant, C. (2013) Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis. PLoS ONE, 8(12), e79861. (doi:10.1371/journal.pone.0079861) (PMID:24324583) (PMCID:PMC3851169)

Pondeville, E., Maria, A., Jacques, J.-C., Bourgouin, C. and Dauphin-Villemant, C. (2008) Anopheles gambiae males produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating. Proceedings of the National Academy of Sciences of the United States of America, 105(50), pp. 19631-19636. (doi:10.1073/pnas.0809264105)

Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carré, C., Noselli, S. and Léopold, P. (2005) Antagonistic actions of ecdysone and insulins determine final size in drosophila. Science, 310(5748), pp. 667-670. (doi:10.1126/science.1119432) (PMID:16179433)

This list was generated on Sat Dec 15 22:14:12 2018 GMT.


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