Dr Julien Reboud
- Senior Lecturer (Biomedical Engineering)
Using my experience from a PhD in France (Université Joseph Fourier/CEA) and post-doctoral work in the Institute of Microelectronics (A-STAR) in Singapore, I have established a track record in developing and integrating microfluidic systems for cell-based assays, including both high content screening for drug discovery and diagnostic tests.
During my PhD, I developed a massively parallel screening platform in microdrops, using surface engineering and advanced image analysis (e.g. segmentation and statistical clustering).
In Singapore, in collaboration with material scientists, I developed structures and surfaces for advanced spectroscopy techniques (e.g. Localised Surface Plasmon Resonance, Surface Enhanced Raman Scattering), as well as for diagnostics, including both immunoassays and nucleic acid-based platforms.
I joined Glasgow University and the group of Prof Jon Cooper in 2009, before securing a Fellowship in 2013 as an independent researcher. Throughout my career, I have pro-actively sought to transfer technologies towards commercialisation, as evidenced through being awarded the PhD prize in the French national start-up competition (2004). In my position at IME in Singapore, I grew from lab bench researcher to project manager (as PI, co-PI and team leader) of small multidisciplinary teams, comprising post-doctoral research assistants, PhD students and technicians. I led a number of collaborations with industry, primarily aimed at integrating microfluidic systems for diagnostics and drug discovery.
I have been awarded The Royal Academy of Engineering ERA Foundation Entrepreneurs prize for the work in Glasgow on acoustic techniques (2013, http://www.raeng.org.uk/prizes/era/), which has led to the spin-out company SAW Dx Ltd (www.sawdx.com). It also was the Highly Commended Technology and Innovation at the Times Higher Education Awards (2014)
I have published more than 30 peer-reviewed papers in international journals, along with 15 patent applications (2 granted).
My current research is focused on integrating engineering and biology for the benefits of healthcare and industry. More particularly, my activities can be divided into two main areas:
- Acoustofluidics for the manipulation of samples, with a particular emphasis on diagnostic applications, at the point-of-care. Surface acoustic waves carry a mechanical energy that can be harvested to manipulate fluids and particles (or living cells). Using advanced microtechnologies, such as phononic crystals (akin to acoustic holograms), this energy can be shaped to obtain specific functions, such as movement and mixing, fully integrated on a disposable microchip. I am interested in the development of advanced techniques to design and fabricate acoustic systems, as well as novel assay designs. A particular emphasis of this research lies with the developments of techniques for low-resource environments such as can be found in the Developing World. Acoustics offer low-cost low-power platforms to perform complex bioassays without the requirement for large infrastructures.
- Synthetic biology. Synthetic biology promises a modular approach to engineer products that allow new components to be discovered, tested and manufactured better, faster and cheaper than existing approaches and on a larger scale. I am interested in using advanced microfluidics and engineering to develop platforms around artificial cells to be used as complete bioreactors and sensor systems. http://www.gla.ac.uk/researchinstitutes/biology/research/syntheticbiology/
Microfluidics, surface acoustic waves (design, fabrication, applications), phononics, microfabrication (photolithography, surface chemistry), cell-based assays, cell manipulation, diagnostics, synthetic biology.
Xu, G., Nolder, D., Reboud, J. , Oguike, M. C., van Schalkwyk, D. A., Sutherland, C. J. and Cooper, J. M. (2016) Paper-origami-based multiplexed malaria diagnostics from whole blood. Angewandte Chemie (International Edition), 55(49), pp. 15250-15253. (doi: 10.1002/anie.201606060) (PMID:27554333) (PMCID:PMC5132111)
Bourquin, Y., Syed, A., Reboud, J. , Ranford-Cartwright, L. C. , Barrett, M. P. and Cooper, J. M. (2014) Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angewandte Chemie (International Edition), 53(22), pp. 5587-5590. (doi: 10.1002/anie.201310401) (PMID:24677583) (PMCID:PMC4232275)
Reboud, J. , Bourquin, Y., Wilson, R. , Pall, G.S., Jiwaji, M., Pitt, A.R., Graham, A., Waters, A.P. and Cooper, J.M. (2012) Shaping acoustic fields as a toolset for microfluidic manipulations in diagnostic technologies. Proceedings of the National Academy of Sciences of the United States of America, 109(38), pp. 15162-15167. (doi: 10.1073/pnas.1206055109)
Faley, S., Copland, M. , Reboud, J. and Cooper, J. M. (2012) Intracellular protein trafficking kinetics in chronic myeloid leukemia stem cells using a microfluidic platform. Integrative Biology, 4(4), p. 368. (doi: 10.1039/c2ib00086e)
Reboud, J. , Wilson, R. , Zhang, Y., Ismail, M. H., Bourquin, Y. and Cooper, J. M. (2012) Nebulisation on a disposable array structured with phononic lattices. Lab on a Chip, 12(7), pp. 1268-1273. (doi: 10.1039/C2LC20705B)
Neuzil, P., Wong, C.C. and Reboud, J. (2010) Electrically controlled giant piezoresistance in silicon nanowires. Nano Letters, 10(4), pp. 1248-1252. (doi: 10.1021/nl9037856)
EPSRC GCRF ISF Point-of-care test for the diagnostic of Malaria in Uganda (2016-2017) collaboration with Uganda.
EPSRC Thin Film Platform Technologies for Conformable and Mechanically Flexible Biosensors (2017-2019). With Notrhumbria.
InnovateUK Biocatalyst. 'APOC' - multiplexed acoustic point of care diagnostic system for STIs (2017-2019). with our spin out company SAW Dx
EPSRC GCRF ISF Diagnostic of Schistosomiasis in Africa (2016-2017). Collaboration with Uganda
BBSRC/DBT. Development of multiplexed diagnostic biosensor for infectious reproductive diseases of cattle and buffaloes (2014-2017), collaboration with India.
Innovate UK. MIMIC: Multifunctional Integrated Microsystem for rapid point-of-care TB IdentifiCation (2013-2016). Multi-partner project including SMEs and clinicans.
Innovate UK MilkED: Development of a point of need diagnostic test for infectious disease in milk (2013-2015). Multi-partner project including SMEs.
I am currently co-supervising the following PhD students:
Hang Zhao - 2013 : Protocells
Meng Xuan - 2013 : error management in FEM
Jumai Abioye - 2014 : Using microfluidics for evolving new enzymes
Victor Ibarra Chavez - 2014 : Synthetic Biology approaches for pathogen detection in water and food safety.
Scott Wood - 2014 : Acoustofluidics for microbiofactories
Mark Bennett - 2015 : Cells mechanotransduction on mobile surfaces
Jonathan Orgill - 2014 : Acoustic actuation of surfaces.
Ross Eaglesfield - 2015 : Artificial Protocells
Ruairidh Edwards - 2016: artificial cells and mitochondria
Sabrina Galinanes Reyes - 2016: programmable vesicles
Alice Garrett - 2016 : LMICs diagnostic devices
Scott Deans- 2016: Acoustic sensing.
I am interested in supervising students on :
- Acoustofluidics for advanced diagnostics
- Diagnostics for the Developing World
- Synthetic Biology for advanced sensors, therapy, and remediation
- New technologies for synthetic biology
Lecturer in :
- Introduction To Biomedical Engineering 1 ENG1031
- Biophysics of Cells and Systems 4 ENG4181
- Biosensors and Diagnostics 4 ENG4036
- Integrated Systems Design Project 4 ENG4085
- Applications of Biomedical Engineering 5 ENG5102
Leading Glasgow's participation to :