Dr Jiabao Xu
- Lecturer (Biomedical Engineering)
https://orcid.org/0000-0002-1285-9408Biography
I am a Lecturer (Assistant Professor) in Biomedical Engineering in the James Watt School of Engineering, which I joined in 2023.
I read Chemistry at Imperial College London (MSci) and completed my PhD in Engineering Science at the University of Oxford in 2020, spending part of it as a Visiting Research Scholar in Chemistry and Engineering at Boston University. I remained at Oxford as a postdoctoral research scientist until moving to Glasgow. Since 2026 I have also held a Visiting Professorship at Shanghai East Hospital, Tongji University.
My research develops single-cell Raman spectroscopy and artificial intelligence to read the chemistry of living cells without labels, and applies it to problems in infection, immunity and chronic disease. I have published more than 40 peer-reviewed outputs, 13 as first or joint first author and 7 as corresponding author, in journals including Nature Communications, Science Advances, PNAS, British Journal of Cancer and Advanced Science. I hold two patents on single-cell sorting and rapid pathogen identification, and I currently lead projects funded by BBSRC, the Royal Society and the Lorna and Yuti Chernajovsky Biomedical Research Foundation.
I am an Associate Editor at Frontiers in Cellular and Infection Microbiology and sit on the editorial boards of iMetaMed and Heliyon. I hold a Fellowship of Recognising Excellence in Teaching (PSF D2).
Personal website: jiabao-xu-glasgow.github.io
Research interests
My research develops single-cell technologies and machine learning for biomedical questions, and applies them across four connected areas.
- Single-cell Raman technologies. Raman-activated cell sorting and ejection, Raman stable isotope probing, and label-free Raman imaging, including high-throughput sorting by stimulated Raman-activated cell ejection.
- Artificial intelligence and data-driven bioanalytics. Deep learning pipelines for disease classification from spectra, multimodal learning across Raman, omics, imaging and clinical metadata, denoising autoencoders and explainable AI.
- Host-pathogen interactions and infectious disease. Culture-free identification of clinical pathogens and antimicrobial resistance profiling at the single-cell level, validated across more than 300 patients and three hospitals.
- Immune cells for disease diagnostics. Label-free Raman profiling of peripheral blood mononuclear cells for chronic fatigue and post-acute infection syndromes including ME/CFS, long COVID and chronic Lyme disease, for inflammatory autoimmune conditions such as psoriatic arthritis and SLE, and for cancer.
I also apply single-cell technologies to stem cell differentiation and ageing, and to engineered cells as a process analytics tool in biomanufacturing.
Publications
2026
Lim, Hao Wei, Xu, Jiabao 
ORCID: https://orcid.org/0000-0002-1285-9408, Koh, Jonas, Cao, Bin, Tu, Weiming and Lotti, Marina
(2026)
Amino acid reprogramming and biofilm-specific tricarboxylate transporters in PET-degrading Piscinibacter sakaiensis.
Applied and Environmental Microbiology,
(doi: 10.1128/aem.01465-26)
(PMID:42708590)
(Early Online Publication)
Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Ma, Yongshuo, Katsimpouras, Constantinos and Stephanopoulos, Gregory
(2026)
Machine learning-driven optimization of metabolic balance for β-carotene production.
Metabolic Engineering, 94,
pp. 192-201.
(doi: 10.1016/j.ymben.2025.12.002)
(PMID:41389980)
2025
Li, Y. et al. (2025) Rapid culture-free diagnosis of clinical pathogens via integrated microfluidic-Raman micro-spectroscopy. Nature Communications, 17, 283. (doi: 10.1038/s41467-025-66996-y) (PMID:41402282) (PMCID:PMC12783191)
Xiong, Wei, Sun, Aijun, Gui, Ting, Xiao, Yaling, Wang, Xue, Zhen, Jingran, Yu, Qi, Deng, Chengyan, Wang, Hanbi and Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408
(2025)
Age‐dependent metabolic signatures in mouse oocytes revealed by single‐cell Raman spectroscopy and high‐resolution imaging.
iMetaMed, 1(1),
e70008.
(doi: 10.1002/imm3.70008)
Wang, Y. et al. (2025) Microwell-assembled aluminum substrates for enhanced single-cell analysis: A novel approach for cancer cell profiling by Raman spectroscopy. Talanta, 283, 127149. (doi: 10.1016/j.talanta.2024.127149) (PMID:39515049)
2024
Zhang, Jing, Lin, Haonan, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhang, Meng, Ge, Xiaowei, Zhang, Chi, Huang, Wei E. and Cheng, Ji-Xin
(2024)
High-throughput single-cell sorting by stimulated Raman-activated cell ejection.
Science Advances, 10(50),
eadn637.
(doi: 10.1126/sciadv.adn6373)
(PMID:39661682)
(PMCID:PMC11633747)
Peng, Qiyun, Dong, Yingfu, Chen, Yecang, Glidle, Andrew, Kong, Lingjiang, Yin, Huabing ORCID: https://orcid.org/0000-0001-7693-377X, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408 and Yang, Kun
(2024)
Rapid profiling of fish cell nitrogen metabolism with single-cell Raman spectroscopy: unveiling enzyme’s role in ammonia detoxification.
Talanta, 277,
1216389.
(doi: 10.1016/j.talanta.2024.126389)
(PMID:38852346)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Chen, Dayang, Wu, Wei, Ji, Xiang, Dou, Xiaowen, Gao, Xiaojuan, Li, Jian, Zhang, Xiuming, Huang, Wei E and Xiong, Dan
(2024)
A metabolic map and artificial intelligence-aided identification of nasopharyngeal carcinoma via a single-cell Raman platform.
British Journal of Cancer, 130,
pp. 1635-1646.
(doi: 10.1038/s41416-024-02637-3)
(PMID:38454165)
Tabish, T. A. et al. (2024) S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications. Redox Biology, 72, 103144. (doi: 10.1016/j.redox.2024.103144) (PMID:38613920) (PMCID:PMC11026843)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408 and Morten, Karl J.
(2024)
Raman micro-spectroscopy as a tool to study immunometabolism.
Biochemical Society Transactions, 52(2),
pp. 733-745.
(doi: 10.1042/BST20230794)
(PMID:38477393)
(PMCID:PMC11088913)
Peng, Qiyun, Sun, Haojie, Neilson, Lisa J., Maknitikul, Sitang, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingjiang, Zanivan, Sara and Yin, Huabing ORCID: https://orcid.org/0000-0001-7693-377X
(2024)
Single-Cell Analysis Reveals the Impact of Tumor-derived matrix on Cancer-Associated Fibroblasts.
In: ICBSP '24: Proceedings of the 2024 9th International Conference on Biomedical Imaging, Signal Processing, Hong Kong Shaanxi Hong Kong, 18-20 Oct 2024,
(doi: 10.1145/3707172.3707191)
2023
Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Thompson, Ian P. and Huang, Wei E.
(2023)
Engineering artificial photosynthesis based on rhodopsin for CO2 fixation.
Nature Communications, 14(1),
8012.
(doi: 10.1038/s41467-023-43524-4)
(PMID:38049399)
(PMCID:PMC10696030)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Lodge, Tiffany, Kingdon, Caroline, Strong, James W. L., Maclennan, John, Lacerda, Eliana, Kujawski, Slawomir, Zalewski, Pawel, Huang, Wei E. and Morten, Karl J.
(2023)
Developing a blood cell‐based diagnostic test for myalgic encephalomyelitis/chronic fatigue syndrome using peripheral blood mononuclear cells.
Advanced Science, 10(30),
2302146.
(doi: 10.1002/advs.202302146)
(PMID:37653608)
(PMCID:PMC10602530)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cui, Li and Song, Yizhi
(2023)
Editorial: Single-cell tools to combat antimicrobial resistance.
Frontiers in Microbiology,
1256107.
(doi: 10.3389/fmicb.2023.1256107)
(PMID:37533820)
(PMCID:PMC10392916)
Yu, Tong, Chandrabhan Jadhav, Archana, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Harris, Adrian L., Nair, Venugopal and Huang, Wei E.
(2023)
Metabolic reprogramming in colon cancer cells persistently infected with Newcastle disease virus.
Cancers, 15(3),
811.
(doi: 10.3390/cancers15030811)
(PMID:36765769)
(PMCID:PMC9913782)
2022
Davison, Paul A., Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Della Valle, Simona, Thompson, Ian P., Neil Hunter, C. and Huang, Wei E.
(2022)
Engineering a rhodopsin-based photo-electrosynthetic system in bacteria for CO2 fixation.
ACS Synthetic Biology, 11(11),
pp. 3805-3816.
(doi: 10.1021/acssynbio.2c00397)
(PMID:36264158)
(PMCID:PMC9680020)
González-Cebrián, A. et al. (2022) Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome with partial least squares discriminant analysis: relevance of blood extracellular vesicles. Frontiers in Medicine, 9, 842991. (doi: 10.3389/fmed.2022.842991)
2021
Wang, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cui, Dongyu, Kong, Lingchao, Chen, Songze, Xie, Wei and Zhang, Chuanlun
(2021)
Classification and identification of archaea using single-cell raman ejection and artificial intelligence: implications for investigating uncultivated microorganisms.
Analytical Chemistry, 93(51),
pp. 17012-17019.
(doi: 10.1021/acs.analchem.1c03495)
(PMID:34910467)
Webb, Isabel, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Sanchez-Canizares, Carmen, Karunakaran, Ramakrishnan, Ramachandran, Vinoy, Rutten, Paul, East, Alison, Huang, Wei, Watmough, Nicholas and Poole, Philip
(2021)
Regulation and characterization of mutants of fixABCX in Rhizobium leguminosarum.
Molecular Plant-Microbe Interactions, 34(10),
pp. 1167-1180.
(doi: 10.1094/mpmi-02-21-0037-r)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Yu, Tong, Zois, Christos E., Cheng, Ji-Xin, Tang, Yuguo, Harris, Adrian L. and Huang, Wei E.
(2021)
Unveiling cancer metabolism through spontaneous and coherent raman spectroscopy and stable isotope probing.
Cancers, 13(7),
1718.
(doi: 10.3390/cancers13071718)
(PMID:33916413)
(PMCID:PMC8038603)
2020
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Li, Xiaojie, Guo, Zhongyue, Huang, Wei E. and Cheng, Ji-Xin
(2020)
Fingerprinting bacterial metabolic response to erythromycin by Raman-integrated mid-infrared photothermal microscopy.
Analytical Chemistry, 92(21),
pp. 14459-14465.
(doi: 10.1021/acs.analchem.0c02489)
(PMID:33089997)
(PMCID:PMC8025921)
Kiat Ng, Chun, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cai, Zhao, Yang, Liang, Thompson, Ian P., Huang, Wei E. and Cao, Bin
(2020)
Elevated intracellular cyclic‐di‐GMP level in Shewanella oneidensis increases expression of c‐type cytochromes.
Microbial Biotechnology, 13(6),
pp. 1904-1916.
(doi: 10.1111/1751-7915.13636)
(PMID:32729223)
(PMCID:PMC7533324)
Hsu, Chia-Chen, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Brinkhof, Bas, Wang, Hui, Cui, Zhanfeng, Huang, Wei E. and Ye, Hua
(2020)
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons.
Proceedings of the National Academy of Sciences of the United States of America, 117(31),
pp. 18412-18423.
(doi: 10.1073/pnas.2001906117)
(PMID:32694205)
(PMCID:PMC7414136)
Wang, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingchao, Li, Bei, Li, Hang, Huang, Wei E. and Zheng, Chunmiao
(2020)
Raman‐activated sorting of antibiotic‐resistant bacteria in human gut microbiota.
Environmental Microbiology, 22(7),
pp. 2613-2624.
(doi: 10.1111/1462-2920.14962)
(PMID:32114713)
(PMCID:PMC7383503)
WANG, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingchao, Liu, Tang, Yi, Lingbo, Wang, Hongjuan, Huang, Wei E. and Zheng, Chunmiao
(2020)
Raman–deuterium isotope probing to study metabolic activities of single bacterial cells in human intestinal microbiota.
Microbial Biotechnology, 13(2),
pp. 572-583.
(doi: 10.1111/1751-7915.13519)
(PMID:31821744)
(PMCID:PMC7017835)
2019
Wang, Yi, Zhang, Zi-Feng, Xu, Xi-Jun, Chen, Chuan, Xu, Jia-Bao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Ling-Chao, Xie, Peng, Zheng, Chun-Miao, Ren, Nan-Qi and Lee, Duu-Jong
(2019)
Effective removal of methyl siloxane from water by sewage activated sludge microbes: biodegradation behavior and characteristics of microbial community.
Bioresource Technology Reports, 7,
100209.
(doi: 10.1016/j.biteb.2019.100209)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Preciado-Llanes, Lorena, Aulicino, Anna, Decker, Christoph Martin, Depke, Maren, Salazar, Manuela Gesell, Schmidt, Frank, Simmons, Alison and Huang, Wei E.
(2019)
Single-cell and time-resolved profiling of intracellular salmonella metabolism in primary human cells.
Analytical Chemistry, 91(12),
pp. 7729-7737.
(doi: 10.1021/acs.analchem.9b01010)
(PMID:31117406)
(PMCID:PMC7006958)
Liang, B. et al. (2019) Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 111(4), 753-762.e1. (doi: 10.1016/j.fertnstert.2018.11.036) (PMID:30683589)
Chen, Jack Xiaoyu, Steel, Harrison, Wu, Yin-Hu, Wang, Yun, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Rampley, Cordelia P.N., Thompson, Ian P., Papachristodoulou, Antonis and Huang, Wei E.
(2019)
Development of aspirin-inducible biosensors in Escherichia coli and SimCells.
Applied and Environmental Microbiology, 85(6),
e02959-18.
(doi: 10.1128/aem.02959-18)
(PMID:30658983)
(PMCID:PMC6414386)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Potter, Michelle, Tomas, Cara, Elson, Joanna L., Morten, Karl J., Poulton, Joanna, Wang, Ning, Jin, Hanqing, Hou, Zhaoxu and Huang, Wei E.
(2019)
A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.
Analyst, 144(3),
pp. 913-920.
(doi: 10.1039/C8AN01437J)
(PMID:30207334)
2017
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhu, D., Ibrahim, A.D., Allen, C.C.R., Gibson, C.M., Fowler, P.W., Song, Y. and Huang, W.E.
(2017)
Raman deuterium isotope probing reveals microbial metabolism at the single-cell level.
Analytical Chemistry, 89(24),
pp. 13305-13312.
(doi: 10.1021/acs.analchem.7b03461)
(PMID:29135226)
Song, Yizhi, Cui, Li, Ángel Siles López, José, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhu, Yong-Guan, Thompson, Ian P. and Huang, Wei E.
(2017)
Raman-deuterium isotope probing for in-situ identification of antimicrobial resistant bacteria in Thames River.
Scientific Reports, 7(1),
16648.
(doi: 10.1038/s41598-017-16898-x)
(PMID:29192181)
(PMCID:PMC5709456)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Webb, I., Poole, P. and Huang, W.E.
(2017)
Label-free discrimination of rhizobial bacteroids and mutants by single-cell Raman microspectroscopy.
Analytical Chemistry, 89(12),
pp. 6336-6340.
(doi: 10.1021/acs.analchem.7b01160)
(PMID:28541039)
Articles
Lim, Hao Wei, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Koh, Jonas, Cao, Bin, Tu, Weiming and Lotti, Marina
(2026)
Amino acid reprogramming and biofilm-specific tricarboxylate transporters in PET-degrading Piscinibacter sakaiensis.
Applied and Environmental Microbiology,
(doi: 10.1128/aem.01465-26)
(PMID:42708590)
(Early Online Publication)
Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Ma, Yongshuo, Katsimpouras, Constantinos and Stephanopoulos, Gregory
(2026)
Machine learning-driven optimization of metabolic balance for β-carotene production.
Metabolic Engineering, 94,
pp. 192-201.
(doi: 10.1016/j.ymben.2025.12.002)
(PMID:41389980)
Li, Y. et al. (2025) Rapid culture-free diagnosis of clinical pathogens via integrated microfluidic-Raman micro-spectroscopy. Nature Communications, 17, 283. (doi: 10.1038/s41467-025-66996-y) (PMID:41402282) (PMCID:PMC12783191)
Xiong, Wei, Sun, Aijun, Gui, Ting, Xiao, Yaling, Wang, Xue, Zhen, Jingran, Yu, Qi, Deng, Chengyan, Wang, Hanbi and Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408
(2025)
Age‐dependent metabolic signatures in mouse oocytes revealed by single‐cell Raman spectroscopy and high‐resolution imaging.
iMetaMed, 1(1),
e70008.
(doi: 10.1002/imm3.70008)
Wang, Y. et al. (2025) Microwell-assembled aluminum substrates for enhanced single-cell analysis: A novel approach for cancer cell profiling by Raman spectroscopy. Talanta, 283, 127149. (doi: 10.1016/j.talanta.2024.127149) (PMID:39515049)
Zhang, Jing, Lin, Haonan, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhang, Meng, Ge, Xiaowei, Zhang, Chi, Huang, Wei E. and Cheng, Ji-Xin
(2024)
High-throughput single-cell sorting by stimulated Raman-activated cell ejection.
Science Advances, 10(50),
eadn637.
(doi: 10.1126/sciadv.adn6373)
(PMID:39661682)
(PMCID:PMC11633747)
Peng, Qiyun, Dong, Yingfu, Chen, Yecang, Glidle, Andrew, Kong, Lingjiang, Yin, Huabing ORCID: https://orcid.org/0000-0001-7693-377X, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408 and Yang, Kun
(2024)
Rapid profiling of fish cell nitrogen metabolism with single-cell Raman spectroscopy: unveiling enzyme’s role in ammonia detoxification.
Talanta, 277,
1216389.
(doi: 10.1016/j.talanta.2024.126389)
(PMID:38852346)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Chen, Dayang, Wu, Wei, Ji, Xiang, Dou, Xiaowen, Gao, Xiaojuan, Li, Jian, Zhang, Xiuming, Huang, Wei E and Xiong, Dan
(2024)
A metabolic map and artificial intelligence-aided identification of nasopharyngeal carcinoma via a single-cell Raman platform.
British Journal of Cancer, 130,
pp. 1635-1646.
(doi: 10.1038/s41416-024-02637-3)
(PMID:38454165)
Tabish, T. A. et al. (2024) S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications. Redox Biology, 72, 103144. (doi: 10.1016/j.redox.2024.103144) (PMID:38613920) (PMCID:PMC11026843)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408 and Morten, Karl J.
(2024)
Raman micro-spectroscopy as a tool to study immunometabolism.
Biochemical Society Transactions, 52(2),
pp. 733-745.
(doi: 10.1042/BST20230794)
(PMID:38477393)
(PMCID:PMC11088913)
Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Thompson, Ian P. and Huang, Wei E.
(2023)
Engineering artificial photosynthesis based on rhodopsin for CO2 fixation.
Nature Communications, 14(1),
8012.
(doi: 10.1038/s41467-023-43524-4)
(PMID:38049399)
(PMCID:PMC10696030)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Lodge, Tiffany, Kingdon, Caroline, Strong, James W. L., Maclennan, John, Lacerda, Eliana, Kujawski, Slawomir, Zalewski, Pawel, Huang, Wei E. and Morten, Karl J.
(2023)
Developing a blood cell‐based diagnostic test for myalgic encephalomyelitis/chronic fatigue syndrome using peripheral blood mononuclear cells.
Advanced Science, 10(30),
2302146.
(doi: 10.1002/advs.202302146)
(PMID:37653608)
(PMCID:PMC10602530)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cui, Li and Song, Yizhi
(2023)
Editorial: Single-cell tools to combat antimicrobial resistance.
Frontiers in Microbiology,
1256107.
(doi: 10.3389/fmicb.2023.1256107)
(PMID:37533820)
(PMCID:PMC10392916)
Yu, Tong, Chandrabhan Jadhav, Archana, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Harris, Adrian L., Nair, Venugopal and Huang, Wei E.
(2023)
Metabolic reprogramming in colon cancer cells persistently infected with Newcastle disease virus.
Cancers, 15(3),
811.
(doi: 10.3390/cancers15030811)
(PMID:36765769)
(PMCID:PMC9913782)
Davison, Paul A., Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Della Valle, Simona, Thompson, Ian P., Neil Hunter, C. and Huang, Wei E.
(2022)
Engineering a rhodopsin-based photo-electrosynthetic system in bacteria for CO2 fixation.
ACS Synthetic Biology, 11(11),
pp. 3805-3816.
(doi: 10.1021/acssynbio.2c00397)
(PMID:36264158)
(PMCID:PMC9680020)
González-Cebrián, A. et al. (2022) Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome with partial least squares discriminant analysis: relevance of blood extracellular vesicles. Frontiers in Medicine, 9, 842991. (doi: 10.3389/fmed.2022.842991)
Wang, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cui, Dongyu, Kong, Lingchao, Chen, Songze, Xie, Wei and Zhang, Chuanlun
(2021)
Classification and identification of archaea using single-cell raman ejection and artificial intelligence: implications for investigating uncultivated microorganisms.
Analytical Chemistry, 93(51),
pp. 17012-17019.
(doi: 10.1021/acs.analchem.1c03495)
(PMID:34910467)
Webb, Isabel, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Sanchez-Canizares, Carmen, Karunakaran, Ramakrishnan, Ramachandran, Vinoy, Rutten, Paul, East, Alison, Huang, Wei, Watmough, Nicholas and Poole, Philip
(2021)
Regulation and characterization of mutants of fixABCX in Rhizobium leguminosarum.
Molecular Plant-Microbe Interactions, 34(10),
pp. 1167-1180.
(doi: 10.1094/mpmi-02-21-0037-r)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Yu, Tong, Zois, Christos E., Cheng, Ji-Xin, Tang, Yuguo, Harris, Adrian L. and Huang, Wei E.
(2021)
Unveiling cancer metabolism through spontaneous and coherent raman spectroscopy and stable isotope probing.
Cancers, 13(7),
1718.
(doi: 10.3390/cancers13071718)
(PMID:33916413)
(PMCID:PMC8038603)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Li, Xiaojie, Guo, Zhongyue, Huang, Wei E. and Cheng, Ji-Xin
(2020)
Fingerprinting bacterial metabolic response to erythromycin by Raman-integrated mid-infrared photothermal microscopy.
Analytical Chemistry, 92(21),
pp. 14459-14465.
(doi: 10.1021/acs.analchem.0c02489)
(PMID:33089997)
(PMCID:PMC8025921)
Kiat Ng, Chun, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cai, Zhao, Yang, Liang, Thompson, Ian P., Huang, Wei E. and Cao, Bin
(2020)
Elevated intracellular cyclic‐di‐GMP level in Shewanella oneidensis increases expression of c‐type cytochromes.
Microbial Biotechnology, 13(6),
pp. 1904-1916.
(doi: 10.1111/1751-7915.13636)
(PMID:32729223)
(PMCID:PMC7533324)
Hsu, Chia-Chen, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Brinkhof, Bas, Wang, Hui, Cui, Zhanfeng, Huang, Wei E. and Ye, Hua
(2020)
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons.
Proceedings of the National Academy of Sciences of the United States of America, 117(31),
pp. 18412-18423.
(doi: 10.1073/pnas.2001906117)
(PMID:32694205)
(PMCID:PMC7414136)
Wang, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingchao, Li, Bei, Li, Hang, Huang, Wei E. and Zheng, Chunmiao
(2020)
Raman‐activated sorting of antibiotic‐resistant bacteria in human gut microbiota.
Environmental Microbiology, 22(7),
pp. 2613-2624.
(doi: 10.1111/1462-2920.14962)
(PMID:32114713)
(PMCID:PMC7383503)
WANG, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingchao, Liu, Tang, Yi, Lingbo, Wang, Hongjuan, Huang, Wei E. and Zheng, Chunmiao
(2020)
Raman–deuterium isotope probing to study metabolic activities of single bacterial cells in human intestinal microbiota.
Microbial Biotechnology, 13(2),
pp. 572-583.
(doi: 10.1111/1751-7915.13519)
(PMID:31821744)
(PMCID:PMC7017835)
Wang, Yi, Zhang, Zi-Feng, Xu, Xi-Jun, Chen, Chuan, Xu, Jia-Bao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Ling-Chao, Xie, Peng, Zheng, Chun-Miao, Ren, Nan-Qi and Lee, Duu-Jong
(2019)
Effective removal of methyl siloxane from water by sewage activated sludge microbes: biodegradation behavior and characteristics of microbial community.
Bioresource Technology Reports, 7,
100209.
(doi: 10.1016/j.biteb.2019.100209)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Preciado-Llanes, Lorena, Aulicino, Anna, Decker, Christoph Martin, Depke, Maren, Salazar, Manuela Gesell, Schmidt, Frank, Simmons, Alison and Huang, Wei E.
(2019)
Single-cell and time-resolved profiling of intracellular salmonella metabolism in primary human cells.
Analytical Chemistry, 91(12),
pp. 7729-7737.
(doi: 10.1021/acs.analchem.9b01010)
(PMID:31117406)
(PMCID:PMC7006958)
Liang, B. et al. (2019) Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 111(4), 753-762.e1. (doi: 10.1016/j.fertnstert.2018.11.036) (PMID:30683589)
Chen, Jack Xiaoyu, Steel, Harrison, Wu, Yin-Hu, Wang, Yun, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Rampley, Cordelia P.N., Thompson, Ian P., Papachristodoulou, Antonis and Huang, Wei E.
(2019)
Development of aspirin-inducible biosensors in Escherichia coli and SimCells.
Applied and Environmental Microbiology, 85(6),
e02959-18.
(doi: 10.1128/aem.02959-18)
(PMID:30658983)
(PMCID:PMC6414386)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Potter, Michelle, Tomas, Cara, Elson, Joanna L., Morten, Karl J., Poulton, Joanna, Wang, Ning, Jin, Hanqing, Hou, Zhaoxu and Huang, Wei E.
(2019)
A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.
Analyst, 144(3),
pp. 913-920.
(doi: 10.1039/C8AN01437J)
(PMID:30207334)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhu, D., Ibrahim, A.D., Allen, C.C.R., Gibson, C.M., Fowler, P.W., Song, Y. and Huang, W.E.
(2017)
Raman deuterium isotope probing reveals microbial metabolism at the single-cell level.
Analytical Chemistry, 89(24),
pp. 13305-13312.
(doi: 10.1021/acs.analchem.7b03461)
(PMID:29135226)
Song, Yizhi, Cui, Li, Ángel Siles López, José, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhu, Yong-Guan, Thompson, Ian P. and Huang, Wei E.
(2017)
Raman-deuterium isotope probing for in-situ identification of antimicrobial resistant bacteria in Thames River.
Scientific Reports, 7(1),
16648.
(doi: 10.1038/s41598-017-16898-x)
(PMID:29192181)
(PMCID:PMC5709456)
Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Webb, I., Poole, P. and Huang, W.E.
(2017)
Label-free discrimination of rhizobial bacteroids and mutants by single-cell Raman microspectroscopy.
Analytical Chemistry, 89(12),
pp. 6336-6340.
(doi: 10.1021/acs.analchem.7b01160)
(PMID:28541039)
Conference Proceedings
Peng, Qiyun, Sun, Haojie, Neilson, Lisa J., Maknitikul, Sitang, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingjiang, Zanivan, Sara and Yin, Huabing ORCID: https://orcid.org/0000-0001-7693-377X
(2024)
Single-Cell Analysis Reveals the Impact of Tumor-derived matrix on Cancer-Associated Fibroblasts.
In: ICBSP '24: Proceedings of the 2024 9th International Conference on Biomedical Imaging, Signal Processing, Hong Kong Shaanxi Hong Kong, 18-20 Oct 2024,
(doi: 10.1145/3707172.3707191)
Grants
Current
- BBSRC, Transformative Research Technologies (2025 call). Unlocking the Phenotypic Dark Matter of the Microbial World via Plasmon-Enhanced Expansion Nanoscopy (PEEN). Principal Investigator, £173,341, 2026 to 2027.
- Lorna and Yuti Chernajovsky Biomedical Research Foundation. DECODE-FATIGUE: Deciphering Oxidative and Neurometabolic Drivers of Fatigue in Immune-Mediated Inflammatory Diseases via Single-Cell Raman Spectroscopy. Principal Investigator, £190,738, 2026 to 2028.
- Royal Society Research Grants. Rapid Identification of Bioplastic-Producing Microbes from Waste by Single-Cell Raman Sorting. Principal Investigator, £30,000, 2025 to 2027.
Completed
- NHS Greater Glasgow and Clyde Endowment Funds. Investigating Putative Central-Peripheral Metabolic Mechanisms in Psoriatic Arthritis Related Fatigue. Co-Investigator, £11,220, 2024 to 2025.
- University of Glasgow ECDP Rewards for Excellence. A single-cell platform for diagnosis and investigation of unexplained post-infection chronic fatigue syndromes. Principal Investigator, £10,000, 2024.
- UK-China Antimicrobial Resistance Initiative, Innovate UK / UKRI. Named researcher, £750,000, from 2020.
- ME Research UK. Named researcher, £50,000, from 2019.
- ME Association. Named researcher, £9,600, from 2018.
Supervision
I welcome enquiries from prospective PhD students interested in single-cell Raman spectroscopy, machine learning for biomedical data, infection diagnostics or immune profiling. Please contact me by email with a CV and a short statement of research interests.
Teaching
I contribute to the following courses in the James Watt School of Engineering.
- Advanced Artificial Intelligence and Machine Learning 5 (Level 5 and Masters)
- Introduction to Artificial Intelligence and Machine Learning (Level 4)
- Engineering Maths 1 (first year, cohort of more than 300 students, two blocks of 14 lecture modules annually)
- Business Planning and Management for Engineers (fourth year, all engineering disciplines)
- Overseas Immersion Programme, SIT and University of Glasgow Joint Degree Programmes (first-year engineering and computing students, approximately 400)
I hold a Fellowship of Recognising Excellence in Teaching (PSF D2, 2025).
Professional activities & recognition
Editorial boards
- 2022: Frontiers in Microbiology
- 2022: Cancers
- 2024: Heliyon
Selected international presentations
- 2017: ASM Microbe (New Orleans, USA)
- 2023: ILADS (Boston, USA)
Additional information
Editorial roles
- Associate Editor, Frontiers in Cellular and Infection Microbiology, Antibiotic Resistance and New Antimicrobial Drugs section
- Editorial Board Member, iMetaMed
- Editorial Board Member, Heliyon
Guest editorships
- 2026: Frontiers in Cellular and Infection Microbiology, Integrative Physics-Informed AI for Multi-Scale Modeling of Host-Pathogen and Microbiome Interactions
- 2025: Frontiers in Cellular and Infection Microbiology, Advances in Combating Antimicrobial Resistance: Focus on Diagnosis, Therapy, and Prevention
- 2023: Frontiers in Microbiology, Single-Cell Tools to Combat Antimicrobial Resistance
- 2023: Cancers, Single-Cell Toolkits in Cancer Research
Peer review and panels
- 2025: Leverhulme Trust Early Career Fellowship internal selection panel, University of Glasgow
- 2025: Fellowship reviewer, Daphne Jackson Trust
- 2025: BioMedEng conference review panel
- 2025: ACS Peer Review Recognition
- 2024: Grant reviewer, UKRI EPSRC Access to High Performance Computing
- Regular reviewer for Nature Communications, Nature Microbiology, Science Advances, Analytical Chemistry, Talanta and Microbial Biotechnology
Selected invited talks
- 2026: Single-Cell Technology and AI for Precision Medicine, Wuhan Third Hospital, China
- 2026: PRIME workshop (Patients, Researchers and Industry for ME)
- 2024: International Young Scholars Conference on TCM plus Interdisciplinary, Zhejiang Chinese Medical University, China
- 2023: Keynote, International Lyme and Associated Diseases Society (ILADS) Conference, Boston, USA
- 2023: ME/CFS Research Roadmap, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
- 2022: Rheumatology and Immunology Forum, Peking University People's Hospital, Beijing, China
- 2021: Session chair, Single Cell Technology meets Microbiomics, UK
- 2017: ASM Microbe, New Orleans, USA
Patents
- Image-guided cell sorting and uses. US Provisional Application 63/542,652.
- Rapid identification instrument and identification method for pathogenic microorganisms. CN111220589A.
