Dr Jiabao Xu

Lecturer (Biomedical Engineering)

Biography

After completing my MSci degree in Chemistry at Imperial College London, I obtained my PhD degree in Engineering Science from the University of Oxford in 2020. I joined the Univeristy of Glasgow as a lecturer in 2023. My research focus has been around single-cell techniques, exploring diverse aspects of cellular metabolism in bacteria and mammalian cells. My work, featured in leading journals like PNAS, Advanced Science and Analytical Chemistry, has positioned me as an innovator in single-cell studies.

I have been at the forefront of new innovations in the development of data mining and artificial intelligence models in single-cell Raman studies. My expertise has been instrumental in an Innovate UK-China call for the identification of clinical pathogens by Raman spectroscopy using large datasets (>500k single-cell spectra). Currently, the methods are undergoing extensive validation studies in a series of hospitals in China.

Since 2016, I have been investigating cell metabolism in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This work has yielded promising results, including the discovery of novel biomarkers in the blood of ME/CFS patients as well as a pioneering single-cell Raman platform enhanced by ensemble learning as a diagnostic test. This approach demonstrated exceptional promise as a diagnostic tool for ME/CFS, achieving an accuracy rate of 91% across 98 subjects. The implications of this innovation extend beyond ME/CFS, holding great potential for diagnosing a wide range of chronic diseases.

My research journey equipped me with expertise in single-cell Raman spectroscopy, advanced optical imaging, cell sorting, isotope probing, data mining and artificial intelligence. I have published 22 peer-reviewed papers and a book chapter on Raman applications. I have served as guest editors in Frontiers in Microbiology and Cancers, leading themes focused on single-cell technologies.

Research interests

My current reserarch interests are development and applications of single-cell technologies in the biomedical field. More particularly, my activities encompass the following domains:

Single-cell Raman diagnosis of diseases using PBMCs from blood with a focus on chronic fatigue, such as post-acute infection chronic syndromes like ME/CFS, long COVID and chronic Lyme diseases, as well as inflammatory autoimmune diseases.
Mutimodal data mining combining single-cell, omics, and clinical data to address biomedical questions
Stem cell research using single-cell technologies to look at stem cell differentiation stages and aging

Publications

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Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2017

Number of items: 28.

2025

Wang, Y. et al. (2025) Microwell-assembled aluminum substrates for enhanced single-cell analysis: A novel approach for cancer cell profiling by Raman spectroscopy. Talanta, 283, 127149. (doi: 10.1016/j.talanta.2024.127149) (PMID:39515049)

2024

Zhang, Jing, Lin, Haonan, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhang, Meng, Ge, Xiaowei, Zhang, Chi, Huang, Wei E. and Cheng, Ji-Xin (2024) High-throughput single-cell sorting by stimulated Raman-activated cell ejection. Science Advances, 10(50), eadn637. (doi: 10.1126/sciadv.adn6373) (PMID:39661682) (PMCID:PMC11633747)

Peng, Qiyun, Dong, Yingfu, Chen, Yecang, Glidle, Andrew, Kong, Lingjiang, Yin, Huabing ORCID: https://orcid.org/0000-0001-7693-377X, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408 and Yang, Kun (2024) Rapid profiling of fish cell nitrogen metabolism with single-cell Raman spectroscopy: unveiling enzyme’s role in ammonia detoxification. Talanta, 277, 1216389. (doi: 10.1016/j.talanta.2024.126389) (PMID:38852346)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Chen, Dayang, Wu, Wei, Ji, Xiang, Dou, Xiaowen, Gao, Xiaojuan, Li, Jian, Zhang, Xiuming, Huang, Wei E and Xiong, Dan (2024) A metabolic map and artificial intelligence-aided identification of nasopharyngeal carcinoma via a single-cell Raman platform. British Journal of Cancer, 130, pp. 1635-1646. (doi: 10.1038/s41416-024-02637-3) (PMID:38454165)

Tabish, T. A. et al. (2024) S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications. Redox Biology, 72, 103144. (doi: 10.1016/j.redox.2024.103144) (PMID:38613920) (PMCID:PMC11026843)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408 and Morten, Karl J. (2024) Raman micro-spectroscopy as a tool to study immunometabolism. Biochemical Society Transactions, 52(2), pp. 733-745. (doi: 10.1042/BST20230794) (PMID:38477393) (PMCID:PMC11088913)

Peng, Qiyun, Sun, Haojie, Neilson, Lisa J., Maknitikul, Sitang, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingjiang, Zanivan, Sara and Yin, Huabing ORCID: https://orcid.org/0000-0001-7693-377X (2024) Single-Cell Analysis Reveals the Impact of Tumor-derived matrix on Cancer-Associated Fibroblasts. In: ICBSP '24: Proceedings of the 2024 9th International Conference on Biomedical Imaging, Signal Processing, Hong Kong Shaanxi Hong Kong, 18-20 Oct 2024, (doi: 10.1145/3707172.3707191)

2023

Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Thompson, Ian P. and Huang, Wei E. (2023) Engineering artificial photosynthesis based on rhodopsin for CO2 fixation. Nature Communications, 14(1), 8012. (doi: 10.1038/s41467-023-43524-4) (PMID:38049399) (PMCID:PMC10696030)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Lodge, Tiffany, Kingdon, Caroline, Strong, James W. L., Maclennan, John, Lacerda, Eliana, Kujawski, Slawomir, Zalewski, Pawel, Huang, Wei E. and Morten, Karl J. (2023) Developing a blood cell‐based diagnostic test for myalgic encephalomyelitis/chronic fatigue syndrome using peripheral blood mononuclear cells. Advanced Science, 10(30), 2302146. (doi: 10.1002/advs.202302146) (PMID:37653608) (PMCID:PMC10602530)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cui, Li and Song, Yizhi (2023) Editorial: Single-cell tools to combat antimicrobial resistance. Frontiers in Microbiology, 1256107. (doi: 10.3389/fmicb.2023.1256107) (PMID:37533820) (PMCID:PMC10392916)

2022

Davison, Paul A., Tu, Weiming, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Della Valle, Simona, Thompson, Ian P., Neil Hunter, C. and Huang, Wei E. (2022) Engineering a rhodopsin-based photo-electrosynthetic system in bacteria for CO2 fixation. ACS Synthetic Biology, 11(11), pp. 3805-3816. (doi: 10.1021/acssynbio.2c00397) (PMID:36264158) (PMCID:PMC9680020)

González-Cebrián, A. et al. (2022) Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome with partial least squares discriminant analysis: relevance of blood extracellular vesicles. Frontiers in Medicine, 9, 842991. (doi: 10.3389/fmed.2022.842991)

2021

Wang, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cui, Dongyu, Kong, Lingchao, Chen, Songze, Xie, Wei and Zhang, Chuanlun (2021) Classification and identification of archaea using single-cell raman ejection and artificial intelligence: implications for investigating uncultivated microorganisms. Analytical Chemistry, 93(51), pp. 17012-17019. (doi: 10.1021/acs.analchem.1c03495) (PMID:34910467)

Webb, Isabel, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Sanchez-Canizares, Carmen, Karunakaran, Ramakrishnan, Ramachandran, Vinoy, Rutten, Paul, East, Alison, Huang, Wei, Watmough, Nicholas and Poole, Philip (2021) Regulation and characterization of mutants of fixABCX in Rhizobium leguminosarum. Molecular Plant-Microbe Interactions, 34(10), pp. 1167-1180. (doi: 10.1094/mpmi-02-21-0037-r)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Yu, Tong, Zois, Christos E., Cheng, Ji-Xin, Tang, Yuguo, Harris, Adrian L. and Huang, Wei E. (2021) Unveiling cancer metabolism through spontaneous and coherent raman spectroscopy and stable isotope probing. Cancers, 13(7), 1718. (doi: 10.3390/cancers13071718) (PMID:33916413) (PMCID:PMC8038603)

2020

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Li, Xiaojie, Guo, Zhongyue, Huang, Wei E. and Cheng, Ji-Xin (2020) Fingerprinting bacterial metabolic response to erythromycin by Raman-integrated mid-infrared photothermal microscopy. Analytical Chemistry, 92(21), pp. 14459-14465. (doi: 10.1021/acs.analchem.0c02489) (PMID:33089997) (PMCID:PMC8025921)

Kiat Ng, Chun, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Cai, Zhao, Yang, Liang, Thompson, Ian P., Huang, Wei E. and Cao, Bin (2020) Elevated intracellular cyclic‐di‐GMP level in Shewanella oneidensis increases expression of c‐type cytochromes. Microbial Biotechnology, 13(6), pp. 1904-1916. (doi: 10.1111/1751-7915.13636) (PMID:32729223) (PMCID:PMC7533324)

Hsu, Chia-Chen, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Brinkhof, Bas, Wang, Hui, Cui, Zhanfeng, Huang, Wei E. and Ye, Hua (2020) A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons. Proceedings of the National Academy of Sciences of the United States of America, 117(31), pp. 18412-18423. (doi: 10.1073/pnas.2001906117) (PMID:32694205) (PMCID:PMC7414136)

Wang, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingchao, Li, Bei, Li, Hang, Huang, Wei E. and Zheng, Chunmiao (2020) Raman‐activated sorting of antibiotic‐resistant bacteria in human gut microbiota. Environmental Microbiology, 22(7), pp. 2613-2624. (doi: 10.1111/1462-2920.14962) (PMID:32114713) (PMCID:PMC7383503)

WANG, Yi, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Lingchao, Liu, Tang, Yi, Lingbo, Wang, Hongjuan, Huang, Wei E. and Zheng, Chunmiao (2020) Raman–deuterium isotope probing to study metabolic activities of single bacterial cells in human intestinal microbiota. Microbial Biotechnology, 13(2), pp. 572-583. (doi: 10.1111/1751-7915.13519) (PMID:31821744) (PMCID:PMC7017835)

2019

Wang, Yi, Zhang, Zi-Feng, Xu, Xi-Jun, Chen, Chuan, Xu, Jia-Bao ORCID: https://orcid.org/0000-0002-1285-9408, Kong, Ling-Chao, Xie, Peng, Zheng, Chun-Miao, Ren, Nan-Qi and Lee, Duu-Jong (2019) Effective removal of methyl siloxane from water by sewage activated sludge microbes: biodegradation behavior and characteristics of microbial community. Bioresource Technology Reports, 7, 100209. (doi: 10.1016/j.biteb.2019.100209)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Preciado-Llanes, Lorena, Aulicino, Anna, Decker, Christoph Martin, Depke, Maren, Salazar, Manuela Gesell, Schmidt, Frank, Simmons, Alison and Huang, Wei E. (2019) Single-cell and time-resolved profiling of intracellular salmonella metabolism in primary human cells. Analytical Chemistry, 91(12), pp. 7729-7737. (doi: 10.1021/acs.analchem.9b01010) (PMID:31117406) (PMCID:PMC7006958)

Liang, B. et al. (2019) Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 111(4), 753-762.e1. (doi: 10.1016/j.fertnstert.2018.11.036) (PMID:30683589)

Chen, Jack Xiaoyu, Steel, Harrison, Wu, Yin-Hu, Wang, Yun, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Rampley, Cordelia P.N., Thompson, Ian P., Papachristodoulou, Antonis and Huang, Wei E. (2019) Development of aspirin-inducible biosensors in Escherichia coli and SimCells. Applied and Environmental Microbiology, 85(6), e02959-18. (doi: 10.1128/aem.02959-18) (PMID:30658983) (PMCID:PMC6414386)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Potter, Michelle, Tomas, Cara, Elson, Joanna L., Morten, Karl J., Poulton, Joanna, Wang, Ning, Jin, Hanqing, Hou, Zhaoxu and Huang, Wei E. (2019) A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy. Analyst, 144(3), pp. 913-920. (doi: 10.1039/C8AN01437J) (PMID:30207334)

2017

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhu, D., Ibrahim, A.D., Allen, C.C.R., Gibson, C.M., Fowler, P.W., Song, Y. and Huang, W.E. (2017) Raman deuterium isotope probing reveals microbial metabolism at the single-cell level. Analytical Chemistry, 89(24), pp. 13305-13312. (doi: 10.1021/acs.analchem.7b03461) (PMID:29135226)

Song, Yizhi, Cui, Li, Ángel Siles López, José, Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Zhu, Yong-Guan, Thompson, Ian P. and Huang, Wei E. (2017) Raman-deuterium isotope probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Scientific Reports, 7(1), 16648. (doi: 10.1038/s41598-017-16898-x) (PMID:29192181) (PMCID:PMC5709456)

Xu, Jiabao ORCID: https://orcid.org/0000-0002-1285-9408, Webb, I., Poole, P. and Huang, W.E. (2017) Label-free discrimination of rhizobial bacteroids and mutants by single-cell Raman microspectroscopy. Analytical Chemistry, 89(12), pp. 6336-6340. (doi: 10.1021/acs.analchem.7b01160) (PMID:28541039)

This list was generated on Tue Jun 24 19:21:30 2025 BST.

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Number of items: 28.

Articles

Conference Proceedings