James Watt School of Engineering

Dr Helen Mulvana

Lecturer (Systems Power & Energy)

telephone: 01413305044
email: Helen.Mulvana@glasgow.ac.uk

Research interests

My research focuses on the use of ultrasound and contrast ultrasound for the treatment and early diagnosis of disease.

As a mechanical engineer I collaborate with clinicians and researchers in chemistry, life sciences and cell biology.

Current projects include

Development of magnetomotive ultrasound elastography imaging for earlier diagnosis of colorectal cancer

Development of physiologically relevant flow phantoms to study ultasound mediated targeted drug delivery

Investigation of ultrasound mediated gene delivery as a means to treat pre-eclampsia during pregnancy

Development of novel ultrasound devices for combined cutting and therapy

Grants

‘Development of non-ionising and non-invasive, personalised colorectal cancer staging using novel multimodal contrast agents and magnetomotive ultrasound imaging’ - Multidisciplinary Project Award, Cancer Research UK, PI (£460k), August 2017 – July 2021.
‘Physiologically and anatomically accurate flow phantom for controlled investigation of ultrasound and microbubble mediated targeted drug delivery’ - Collaborative Research Grant, Carnegie Trust, PI (£45.5k), February 2017 – January 2019.
‘Contrast enhanced ultrasound (ceus) to advance individual staging and treatment planning in rectal cancer’ - Small Grant, Bowel and Cancer Research, co-PI (£49k), August 2017 – July 2019.
‘Microscope based flow phantom for controlled investigation of ultrasound and microbubble targeted drug delivery’ - Research Grant, Royal Society, PI (£15k), March 2016 – March 2018.
‘Custom Bubbles’ - Scottish Crucible Award, Royal Society of Edinburgh, PI (£2.6k)

Supervision

PhD Candidates

Jill Savva

Sonya Frazier

If you are interested in PhD research on topics related to my work please contact me.

Teaching

Introduction to Biomedical Engineering 1

Biophysics of Cells and Systems 4

Advanced Imaging and Therapy 5

Coordinator for the Introduction to Biomedical Engineering research seminar series

Additional information

Associate Editor for IEEE Ultrasonics, Ferroelectrics and Frequency Control (https://ieee-uffc.org/publications/transactions-on-uffc/)

Member of the Technical Program Committee for Medical Ultrasound for the IEEE International Ultrasound Symposia

Co-founder and Chair of Scottish Ultrasound (http://www.scottishultrasound.org.uk/)

Co-chair of the School of Engineering Athena Swan Self-Assessment Team, awarded Bronze in Octobner 2016 (http://www.gla.ac.uk/schools/engineering/athenaswan/)

Member of the Institute of Physics Physical Acoustics Committee (http://www.iop.org/activity/groups/subject/pa/index.html)

Fellow of the Higher Education Academy

Chartered Engineer through the Institute of Mechanical Engineers

Scottish Crucible participant (2013)

Reviewer for several international journals

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006

Number of items: 29.

2018

Domingo-Roca, R., Jackson, J.C. and Mulvana, H. (2018) Exploitation of Microbubble – Microvessel Interactions to Predict and Personalize UmTDD. Computational and Mathematical Biology Seminar, Barcelona, Spain, 18 Dec 2018. (Unpublished)

Domingo-Roca, R., Jackson, J.C. and Mulvana, H. (2018) Microbubble – Microvessel Interactions and their Influence on UmTDD: Simulation Study. 24th European Symposium on Ultrasound Contrast Imaging, Rotterdam, The Netherlands, 17-18 Jan 2019. (Accepted for Publication)

Domingo-Roca, R., Jackson, J. C. and Mulvana, H. (2018) Development of an Experimental Platform for Rapid Prototyping of UmTDD Methods. Ultrasound 2018, Manchester, UK, 04-06 Dec 2018.

Domingo-Roca, R., Jackson, J.C. and Mulvana, H. (2018) The Importance of Bubble-wall Interaction for Physiologically Relevant Simulations of Ultrasound-mediated Targeted Drug Delivery. IGT Network Meeting, Dundee, UK, 01 Nov 2018.

Stewart, F., Mulvana, H., Näthke, I. and Cochran, S. (2018) Theranostics in the gut. In: Thanou, M. (ed.) Theranostics and Image Guided Drug Delivery. Series: RSC drug discovery series (63). Royal Society of Chemistry: London, pp. 182-210. ISBN 9781782624660 (doi:10.1039/9781788010597-00182)

2017

Cochran, S. , Button, T.W., Cox, B.F., Cumming, D.R.S. , Gourevich, D., Lay, H.S. , Mulvana, H., Nathke, I.S. and Stewart, F. (2017) Nanotechnology in Multimodal Theranostic Capsule Endoscopy. In: IEEE 17th International Conference on Nanotechnology (IEEE-NANO), Pittsburgh, PA, USA, 25-28 July 2017, pp. 434-435. ISBN 9781509030286 (doi:10.1109/NANO.2017.8117439)

Mulvana, H., Browning, R. J., Luan, Y., de Jong, N., Tang, M.-X., Eckersley, R. J. and Stride, E. (2017) Characterization of contrast agent microbubbles for ultrasound imaging and therapy research. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(1), pp. 232-251. (doi:10.1109/TUFFC.2016.2613991) (PMID:27810805)

Stride, E., Mulvana, H., Rademeyer, P., Carugo, D., Owen, J., Browning, R., Tang, M. and Eckersley, R. (2017) Characterisation of functionalised microbubbles for ultrasound imaging and therapy. In: Tsuji, K. (ed.) The Micro-World Observed by Ultra High-Speed Cameras. Springer: Cham, pp. 375-389. ISBN 9783319614908 (doi:10.1007/978-3-319-61491-5_18)

2015

Foster, J. S. et al. (2015) Gelation landscape engineering using a multi-reaction supramolecular hydrogelator system. Journal of the American Chemical Society, 137(45), pp. 14236-14239. (doi:10.1021/jacs.5b06988) (PMID:26502267) (PMCID:PMC4655419)

Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A. and Cochran, S. (2015) In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery. Ultrasound in Medicine and Biology, 41(7), pp. 1853-1864. (doi:10.1016/j.ultrasmedbio.2015.03.016) (PMID:25887690)

2013

Mulvana, H., Cochran, S. and Hill, M. (2013) Ultrasound assisted particle and cell manipulation on-chip. Advanced Drug Delivery Reviews, 65(11-12), pp. 1600-1610. (doi:10.1016/j.addr.2013.07.016)

Casey, J., Sennoga, C., Mulvana, H., Hajnal, J.V., Tang, M.-X. and Eckersley, R.J. (2013) Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound in Medicine and Biology, 39(5), pp. 903-914. (doi:10.1016/j.ultrasmedbio.2012.12.007)

2012

Mulvana, H., Browning, R.J., Tang, M.-X., Hajnal, J.V. and Eckersley, R.J. (2012) Albumin coated microbubble optimization: custom fabrication and comprehensive characterization. Ultrasound in Medicine and Biology, 38(9), pp. 1599-1607. (doi:10.1016/j.ultrasmedbio.2012.05.002)

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J. and Eckersley, R.J. (2012) Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), pp. 1067-1077. (doi:10.1016/j.ultrasmedbio.2012.02.020)

Mulvana, H., Stride, E., Tang, M.-X., Hajnal, J.V. and Eckersley, R.J. (2012) The influence of gas saturation on microbubble stability. Ultrasound in Medicine and Biology, 38(6), pp. 1097-1100. (doi:10.1016/j.ultrasmedbio.2012.02.008)

Mulvana, H., Eckersley, R.J., Tang, M.-X., Pankhurst, Q. and Stride, E. (2012) Theoretical and experimental characterisation of magnetic microbubbles. Ultrasound in Medicine and Biology, 38(5), pp. 864-875. (doi:10.1016/j.ultrasmedbio.2012.01.027)

2011

Browning, R.J., Mulvana, H., Tang, M., Hajnal, J.V., Wells, D.J. and Eckersley, R.J. (2011) Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), pp. 1531-1537. (doi:10.1016/j.ultrasmedbio.2011.05.019)

Mulvana, H., Stride, E., Tang, M., Hajnal, J.V. and Eckersley, R. (2011) Temperature-dependent differences in the nonlinear acoustic behavior of ultrasound contrast agents revealed by high-speed imaging and bulk acoustics. Ultrasound in Medicine and Biology, 37(9), pp. 1509-1517. (doi:10.1016/j.ultrasmedbio.2011.05.020)

Tang, M.-X., Mulvana, H., Gauthier, T., Lim, A.K.P., Cosgrove, D.O., Eckersley, R.J. and Stride, E. (2011) Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focus, 1(4), pp. 520-539. (doi:10.1098/rsfs.2011.0026)

Stride, E., Mulvana, H., Eckersley, R.J., Tang, M.-X. and Pankhurst, Q. (2011) Magnetic microbubbles. In: Thanh, N.T.K. (ed.) Magnetic Nanoparticles: From Fabriation to Clinical Applications. CRC Press: Boca Raton, FL. ISBN 9781439869321

2010

Mulvana, H., Stride, E., Hajnal, J.V. and Eckersley, R.J. (2010) Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), pp. 925-934. (doi:10.1016/j.ultrasmedbio.2010.03.003)

Mulvana, H., Eckersley, R.J., Browning, R., Hajnal, J.V., Stride, E., Barrack, T., Tang, M., Pankhurst, Q. and Wells, D. (2010) Enhanced Gene Transfection in vivo using Magnetic Localisation of Ultrasound Contrast Agents: Preliminary Results. In: IEEE International Ultrasonics Symposium 2010, San Diego, 11-14 Oct 2010, pp. 670-673. (doi:10.1109/ULTSYM.2010.5935952)

2009

Mulvana, H., Eckersley, R.J. and Stride, E. (2009) Temperature behaviour of ultrasound contrast agents. In: IEEE International Ultrasonics Symposium, Rome, Italy, 20-23 Sept 2009, pp. 1239-1242. (doi:10.1109/ULTSYM.2009.5441522)

2007

Wallace, M.F., Marin, P., Mulvana, H., Walsh, M.P., Button, T.W., Hughes, H., MacLennan, D. and Cochran, S. (2007) Applications of New Piezoelectric Materials for High Performance Ultrasonic NDT Transducers. 46th Annual British Conference on Non-Destructive Testing (2007 NDT), Glasgow, UK, 18-20 Sep 2007.

Wallace, M.F., Mulvana, H., Marin, P., Mayne, K., Walsh, M.P., Wright, R., Marsh, R., Spence, B., Solomonidis, S. and Cochran, S. (2007) Parametric Array Design and Characterisation for Underwater Sonar and Medical Strain Imaging Applications. In: 2007 IEEE International Ultrasonics Symposium (IUS), New York, NY, USA, 28-31 Oct 2007, pp. 305-308. ISBN 9781424413836 (doi:10.1109/ULTSYM.2007.87)

2006

Mulvana, H., Parker, M., Saillant, J.-F. and Cochran, S. (2006) Focused Acoustic Radiation Devices for Therapeutic Ultrasound. 2nd Meeting of the UK Therapeutic Ultrasound Group, London, UK, Nov 2006.

Mulvana, H., Cochran, S. , Spence, B., Solomonidis, S. and Mariel, A. (2006) Non-contact Focused Acoustic Radiation Force Technique for the Biomechanical Characterisation of an Amputee’s Residual Limb. Fifth International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity (Tissue Elasticity 2006), Snowbird, UT, USA, 08-11 Oct 2006.

Cochran, S. , Marin-Franch, P., Parker, M., Mulvana, H. and Kirk, K.J. (2006) Ultrasonic Transducers for High Power Applications. Ultrasound in the Processing of Industrial Soft Solids, Leeds, UK, 09-10 Feb 2006.

Mulvana, H., Parker, M.F., Cochran, S. , Spence, B. and Solomonidis, S. (2006) Technique for Automatic Characterisation of an Amputee's Residual Limb. In: IEEE International Ultrasonics Symposium 2006, Vancouver, Canada, 3-6 Oct 2006, pp. 2088-2091. ISBN 9781424402014 (doi:10.1109/ULTSYM.2006.500)

This list was generated on Sun Jun 16 23:37:36 2019 BST.

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