Dr Ankush Aggarwal

  • Lecturer (Infrastructure & Environment)

Research interests

Biography

I am a Lecturer in Engineering and a member of the Glasgow Computational Engineering Centre (GCEC) at the University of Glasgow. I started my college education at the Indian Institute of Technology, Kharagpur and studied Aerospace Engineering. From there, I moved to the University of California, Los Angeles and obtained PhD in Mechanical Engineering with a minor in Applied Mathematics. Afterwards, I worked as a postdoctoral fellow at the Center for Cardiovascular Simulation (CCS), part of ICES, at the University of Texas at Austin. Before joining University of Glasgow, I was a National Research Network Fellow at the Zienkiewicz Centre for Computational Engineering (ZCCE), Swansea University for three years.

Research Interests

We work at the interface of engineering and biomedical research with a focus on solving problems in cardiovascular healthcare technology. Our aim is to improve our understanding of the cardiovascular biomechanics and develop technological tools that will help in decision making in the clinic.

There has been a revival in the medical and biological science with the advanced imaging and fast computation resources widely available. Because of these new abilities, it is now possible to use an engineering approach for medical problems, that is to be more quantitative, objective, and precise in making decisions. We use advanced medical imaging technology and extensive in-vitro and ex-vivo experimental dataset to build detailed computational models that are fast and robust.

More information on can be found on my website


Selected publications

Mei, Y., Hurtado, D. E., Pant, S. and Aggarwal, A. (2018) On improving the numerical convergence of highly nonlinear elasticity problems. Computer Methods in Applied Mechanics and Engineering, 337, pp. 110-127. (doi:10.1016/j.cma.2018.03.033)

Aggarwal, A. (2018) Determination of prestress and elastic properties of virus capsids. Physical Review E, 97, 032414. (doi:10.1103/PhysRevE.97.032414) (PMID:29776150)

Aggarwal, A. (2017) An improved parameter estimation and comparison for soft tissue constitutive models containing an exponential function. Biomechanics and Modeling in Mechanobiology, 16(4), pp. 1309-1327. (doi:10.1007/s10237-017-0889-3) (PMID:28251368) (PMCID:PMC5511618)

Aggarwal, A. and Sacks, M. S. (2016) An inverse modeling approach for semilunar heart valve leaflet mechanics: exploitation of tissue structure. Biomechanics and Modeling in Mechanobiology, 15(4), pp. 909-932. (doi:10.1007/s10237-015-0732-7) (PMID:26449480)

Aggarwal, A. , May, E. R., Brooks, C. L. and Klug, W. S. (2016) Nonuniform elastic properties of macromolecules and effect of prestrain on their continuum nature. Physical Review E, 93, 012417. (doi:10.1103/physreve.93.012417) (PMID:2687111)

Aggarwal, A. , Pouch, A. M., Lai, E., Lesicko, J., Yushkevich, P. A., Gorman III, J. H., Gorman, R. C. and Sacks, M. S. (2016) In-vivo heterogeneous functional and residual strains in human aortic valve leaflets. Journal of Biomechanics, 49(12), pp. 2481-2490. (doi:10.1016/j.jbiomech.2016.04.038) (PMID:27207385) (PMCID:PMC5028253)

Perotti, L. E., Aggarwal, A. , Rudnick, J., Bruinsma, R. and Klug, W. S. (2015) Elasticity theory of the maturation of viral capsids. Journal of the Mechanics and Physics of Solids, 77, pp. 86-108. (doi:10.1016/j.jmps.2015.01.006)

Aggarwal, A. , Ferrari, G., Joyce, E., Daniels, M. J., Sainger, R., Gorman, J. H., Gorman, R. and Sacks, M. S. (2014) Architectural trends in the human normal and bicuspid aortic valve leaflet and its relevance to valve disease. Annals of Biomedical Engineering, 42(5), pp. 986-998. (doi:10.1007/s10439-014-0973-0) (PMID:24488233) (PMCID:PMC4364391)

Aggarwal, A. , Chen, J.-S. and Klug, W.S. (2014) A meshfree method for mechanics and conformational change of proteins and their assemblies. CMES - Computer Modeling in Engineering and Sciences, 98(18), pp. 69-99.

Aggarwal, A. , Rudnick, J., Bruinsma, R.F. and Klug, W.S. (2012) Elasticity theory of macromolecular aggregates. Physical Review Letters, 109, 148102. (doi:10.1103/PhysRevLett.109.148102) (PMID:23083291)


Grants

Principal Investigator

  • Daiwa Foundation 2017 - 2018

    Combined experimental-computational study of cell motility, £3,000

  • Royal Society 2017 - 2018

    Mechanics of cellular monolayers - incorporating cellular biology into biomechanical models, £15,000

  • EPSRC Impact Acceleration Award 2017 - 2018

    Connecting effectively with the clinicians by streamlining the image-to-model pipeline

  • ESPRC 2017 - 2018

    Predicting cardiovascular biomechanical stiffening due to the interplay of tissue layers with focus on calcific aortic valve disease, £100,946

  • Royal Academy of Engineering 2016

    Stratification of patients at high risk of heart valve dysfunction using inverse model - Strengthening the collaboration, £4,950

  • British Council 2016

    Selected for three workshops for early career researchers sponsored by the British Council

  • National Research Network 2015 - 2018

    Modeling pre-strain and growth in biological structures, £150,000

  • American Heart Association 2014 - 2015

    Development of biomechanical identifiers for high risk of bicuspid aortic valve dysfunction, $95,704

Co-Investigator

  • KESS II 2017 - 2020

    Analysis of mechanisms involved in shear stress induced microparticle generation and microparticle mediated effects, £54,250

  • Model2Decision ESPRC Network 2017 - 2018

    Do self-expandable artificial valves offer an advantage over balloon-expandable valves in patients with calcified aortic roots?, £8,104


Supervision

PhD Students

  • Alistair McQueen (second supervisor)

Previous members

  • Dr. Yue Mei, Postdoctoral Research Assistant 2017-18
  • Bashir Balogun, Undergraduate Project Student 2017-18
  • Zainab Abdullah, Undergraduate Project Student 2017-18
  • Joseph Pereira, Undergraduate Project Student 2017-18
  • Ahmed Al Kindi, Undergraduate Project Student 2016-17
  • James Locke, Undergraduate Project Student 2016-17

 

I am looking for motivated PhD students to work on cell mechanics and image-based modeling. Details are available through the following links:

If you are interested in working with me, please feel free to email me.


Additional information

I am looking for motivated PhD students to work on cell mechanics and image-based modeling. Details are available through the following links:

If you are interested in working with me, please feel free to email me.


All publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2009
Number of items: 23.

2018

Chen, J. et al. (2018) Evaluation of the laser-induced thermotherapy treatment effect of breast cancer based on tissue viscoelastic properties. Journal of Engineering and Science in Medical Diagnostics and Therapy, 1(4), 041009. (doi:10.1115/1.4041502)

Mei, Y., Hurtado, D. E., Pant, S. and Aggarwal, A. (2018) On improving the numerical convergence of highly nonlinear elasticity problems. Computer Methods in Applied Mechanics and Engineering, 337, pp. 110-127. (doi:10.1016/j.cma.2018.03.033)

Aggarwal, A. (2018) Determination of prestress and elastic properties of virus capsids. Physical Review E, 97, 032414. (doi:10.1103/PhysRevE.97.032414) (PMID:29776150)

Coccarelli, A., Edwards, D. H., Aggarwal, A. , Nithiarasu, P. and Parthimos, D. (2018) A multiscale active structural model of the arterial wall accounting for smooth muscle dynamics. Journal of the Royal Society: Interface, 15(139), 20170732. (doi:10.1098/rsif.2017.0732) (PMID:29436507) (PMCID:PMC5832725)

2017

Aggarwal, A. (2017) An improved parameter estimation and comparison for soft tissue constitutive models containing an exponential function. Biomechanics and Modeling in Mechanobiology, 16(4), pp. 1309-1327. (doi:10.1007/s10237-017-0889-3) (PMID:28251368) (PMCID:PMC5511618)

2016

Soares, J. S., Feaver, K. R., Zhang, W., Kamensky, D., Aggarwal, A. and Sacks, M. S. (2016) Biomechanical behavior of bioprosthetic heart valve heterograft tissues: characterization, simulation, and performance. Cardiovascular Engineering and Technology, 7(4), pp. 309-351. (doi:10.1007/s13239-016-0276-8) (PMID:27507280) (PMCID:PMC5537391)

Aggarwal, A. , Pouch, A. M., Lai, E., Lesicko, J., Yushkevich, P. A., Gorman III, J. H., Gorman, R. C. and Sacks, M. S. (2016) In-vivo heterogeneous functional and residual strains in human aortic valve leaflets. Journal of Biomechanics, 49(12), pp. 2481-2490. (doi:10.1016/j.jbiomech.2016.04.038) (PMID:27207385) (PMCID:PMC5028253)

Aggarwal, A. and Sacks, M. S. (2016) An inverse modeling approach for semilunar heart valve leaflet mechanics: exploitation of tissue structure. Biomechanics and Modeling in Mechanobiology, 15(4), pp. 909-932. (doi:10.1007/s10237-015-0732-7) (PMID:26449480)

Aggarwal, A. , May, E. R., Brooks, C. L. and Klug, W. S. (2016) Nonuniform elastic properties of macromolecules and effect of prestrain on their continuum nature. Physical Review E, 93, 012417. (doi:10.1103/physreve.93.012417) (PMID:2687111)

2015

Perotti, L. E., Aggarwal, A. , Rudnick, J., Bruinsma, R. and Klug, W. S. (2015) Elasticity theory of the maturation of viral capsids. Journal of the Mechanics and Physics of Solids, 77, pp. 86-108. (doi:10.1016/j.jmps.2015.01.006)

Kamensky, D., Hsu, M.-C., Schillinger, D., Evans, J. A., Aggarwal, A. , Bazilevs, Y., Sacks, M. S. and Hughes, T. J.R. (2015) An immersogeometric variational framework for fluid–structure interaction: Application to bioprosthetic heart valves. Computer Methods in Applied Mechanics and Engineering, 284, pp. 1005-1053. (doi:10.1016/j.cma.2014.10.040) (PMID:25541566) (PMCID:PMC4274080)

Aggarwal, A. and Sacks, M. S. (2015) A framework for determination of heart valves’ mechanical properties using inverse-modeling approach. In: van Assen, H., Bovendeerd, P. and Delhaas, T. (eds.) Functional Imaging and Modeling of the Heart. Series: Lecture notes in computer science (9126). Springer, pp. 285-294. (doi:10.1007/978-3-319-20309-6_33)

Lee, C.-H., Amini, R., Sakamoto, Y., Carruthers, C. A., Aggarwal, A. , Gorman, R. C., Gorman, J. H. and Sacks, M. S. (2015) Mitral valves: a computational framework. In: De, S., Hwang, W. and Kuhl, E. (eds.) Multiscale Modeling in Biomechanics and Mechanobiology. Springer: London, pp. 223-255. ISBN 9781447165989 (doi:10.1007/978-1-4471-6599-6_10)

2014

Aggarwal, A. , Ferrari, G., Joyce, E., Daniels, M. J., Sainger, R., Gorman, J. H., Gorman, R. and Sacks, M. S. (2014) Architectural trends in the human normal and bicuspid aortic valve leaflet and its relevance to valve disease. Annals of Biomedical Engineering, 42(5), pp. 986-998. (doi:10.1007/s10439-014-0973-0) (PMID:24488233) (PMCID:PMC4364391)

Aggarwal, A. and Sacks, M.S. (2014) In-vivo Assessment of Valvular Function: an Inverse Modeling Approach. In: Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014, Barcelona, Spain, 20-25 July 2014, ISBN 9788494284472

Aggarwal, A. , Chen, J.-S. and Klug, W.S. (2014) A meshfree method for mechanics and conformational change of proteins and their assemblies. CMES - Computer Modeling in Engineering and Sciences, 98(18), pp. 69-99.

Aggarwal, A. and Sacks, M. S. (2014) Parameter Estimation of Heart Valve Leaflet Hyperelastic Mechanical Behavior Using an Inverse Modeling Approach. In: 2014 40th Annual Northeast Bioengineering Conference (NEBEC), Boston, MA., 25-27 Apr 2014, pp. 1-2. ISBN 978-1-4799-3728-8 (doi:10.1109/NEBEC.2014.6972704)

2013

Aggarwal, A. , Aguilar, V.S., Lee, C.H., Ferrari, G., Gorman, J.H., Gorman, R.C. and Sacks, M.S. (2013) Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves. In: ASME 2013 Summer Bioengineering Conference, SBC 2013, Sunriver, Oregon, 26-29 June 2013, V01AT04A006. (doi:10.1115/SBC2013-14265)

Aggarwal, A. , Aguilar, V. S., Lee, C.-H., Ferrari, G., Gorman, J. H., Gorman, R. C. and Sacks, M. S. (2013) Patient-specific modeling of heart valves: From image to simulation. In: Ourselin, S., Rueckert, D. and Smith, N. (eds.) Functional Imaging and Modeling of the Heart. Series: Lecture notes in computer science (7945). Springer, pp. 141-149. ISBN 9783642388989 (doi:10.1007/978-3-642-38899-6_17)

2012

Aggarwal, A. , Rudnick, J., Bruinsma, R.F. and Klug, W.S. (2012) Elasticity theory of macromolecular aggregates. Physical Review Letters, 109, 148102. (doi:10.1103/PhysRevLett.109.148102) (PMID:23083291)

Cheng, S., Aggarwal, A. and Stevens, M. J. (2012) Self-assembly of artificial microtubules. Soft Matter, 8(20), pp. 5666-5678. (doi:10.1039/c2sm25068c)

2011

May, E. R., Aggarwal, A. , Klug, W. S. and Brooks, C. L. (2011) Viral capsid equilibrium dynamics reveals nonuniform elastic properties. Biophysical Journal, 100(11), L59-L61. (doi:10.1016/j.bpj.2011.04.026) (PMID:21641297) (PMCID:PMC3117158)

2009

Agarwal, S., Aggarwal, A. , Dasgupta, S. and De, S. (2009) Performance prediction of membrane modules incorporating the effects of suction in the mass transfer coefficient under laminar and turbulent flow conditions for non-Newtonian fluids. Journal of Food Process Engineering, 32(5), pp. 752-774. (doi:10.1111/j.1745-4530.2008.00243.x)

This list was generated on Wed Apr 24 13:48:59 2019 BST.
Number of items: 23.

Articles

Chen, J. et al. (2018) Evaluation of the laser-induced thermotherapy treatment effect of breast cancer based on tissue viscoelastic properties. Journal of Engineering and Science in Medical Diagnostics and Therapy, 1(4), 041009. (doi:10.1115/1.4041502)

Mei, Y., Hurtado, D. E., Pant, S. and Aggarwal, A. (2018) On improving the numerical convergence of highly nonlinear elasticity problems. Computer Methods in Applied Mechanics and Engineering, 337, pp. 110-127. (doi:10.1016/j.cma.2018.03.033)

Aggarwal, A. (2018) Determination of prestress and elastic properties of virus capsids. Physical Review E, 97, 032414. (doi:10.1103/PhysRevE.97.032414) (PMID:29776150)

Coccarelli, A., Edwards, D. H., Aggarwal, A. , Nithiarasu, P. and Parthimos, D. (2018) A multiscale active structural model of the arterial wall accounting for smooth muscle dynamics. Journal of the Royal Society: Interface, 15(139), 20170732. (doi:10.1098/rsif.2017.0732) (PMID:29436507) (PMCID:PMC5832725)

Aggarwal, A. (2017) An improved parameter estimation and comparison for soft tissue constitutive models containing an exponential function. Biomechanics and Modeling in Mechanobiology, 16(4), pp. 1309-1327. (doi:10.1007/s10237-017-0889-3) (PMID:28251368) (PMCID:PMC5511618)

Soares, J. S., Feaver, K. R., Zhang, W., Kamensky, D., Aggarwal, A. and Sacks, M. S. (2016) Biomechanical behavior of bioprosthetic heart valve heterograft tissues: characterization, simulation, and performance. Cardiovascular Engineering and Technology, 7(4), pp. 309-351. (doi:10.1007/s13239-016-0276-8) (PMID:27507280) (PMCID:PMC5537391)

Aggarwal, A. , Pouch, A. M., Lai, E., Lesicko, J., Yushkevich, P. A., Gorman III, J. H., Gorman, R. C. and Sacks, M. S. (2016) In-vivo heterogeneous functional and residual strains in human aortic valve leaflets. Journal of Biomechanics, 49(12), pp. 2481-2490. (doi:10.1016/j.jbiomech.2016.04.038) (PMID:27207385) (PMCID:PMC5028253)

Aggarwal, A. and Sacks, M. S. (2016) An inverse modeling approach for semilunar heart valve leaflet mechanics: exploitation of tissue structure. Biomechanics and Modeling in Mechanobiology, 15(4), pp. 909-932. (doi:10.1007/s10237-015-0732-7) (PMID:26449480)

Aggarwal, A. , May, E. R., Brooks, C. L. and Klug, W. S. (2016) Nonuniform elastic properties of macromolecules and effect of prestrain on their continuum nature. Physical Review E, 93, 012417. (doi:10.1103/physreve.93.012417) (PMID:2687111)

Perotti, L. E., Aggarwal, A. , Rudnick, J., Bruinsma, R. and Klug, W. S. (2015) Elasticity theory of the maturation of viral capsids. Journal of the Mechanics and Physics of Solids, 77, pp. 86-108. (doi:10.1016/j.jmps.2015.01.006)

Kamensky, D., Hsu, M.-C., Schillinger, D., Evans, J. A., Aggarwal, A. , Bazilevs, Y., Sacks, M. S. and Hughes, T. J.R. (2015) An immersogeometric variational framework for fluid–structure interaction: Application to bioprosthetic heart valves. Computer Methods in Applied Mechanics and Engineering, 284, pp. 1005-1053. (doi:10.1016/j.cma.2014.10.040) (PMID:25541566) (PMCID:PMC4274080)

Aggarwal, A. , Ferrari, G., Joyce, E., Daniels, M. J., Sainger, R., Gorman, J. H., Gorman, R. and Sacks, M. S. (2014) Architectural trends in the human normal and bicuspid aortic valve leaflet and its relevance to valve disease. Annals of Biomedical Engineering, 42(5), pp. 986-998. (doi:10.1007/s10439-014-0973-0) (PMID:24488233) (PMCID:PMC4364391)

Aggarwal, A. , Chen, J.-S. and Klug, W.S. (2014) A meshfree method for mechanics and conformational change of proteins and their assemblies. CMES - Computer Modeling in Engineering and Sciences, 98(18), pp. 69-99.

Aggarwal, A. , Rudnick, J., Bruinsma, R.F. and Klug, W.S. (2012) Elasticity theory of macromolecular aggregates. Physical Review Letters, 109, 148102. (doi:10.1103/PhysRevLett.109.148102) (PMID:23083291)

Cheng, S., Aggarwal, A. and Stevens, M. J. (2012) Self-assembly of artificial microtubules. Soft Matter, 8(20), pp. 5666-5678. (doi:10.1039/c2sm25068c)

May, E. R., Aggarwal, A. , Klug, W. S. and Brooks, C. L. (2011) Viral capsid equilibrium dynamics reveals nonuniform elastic properties. Biophysical Journal, 100(11), L59-L61. (doi:10.1016/j.bpj.2011.04.026) (PMID:21641297) (PMCID:PMC3117158)

Agarwal, S., Aggarwal, A. , Dasgupta, S. and De, S. (2009) Performance prediction of membrane modules incorporating the effects of suction in the mass transfer coefficient under laminar and turbulent flow conditions for non-Newtonian fluids. Journal of Food Process Engineering, 32(5), pp. 752-774. (doi:10.1111/j.1745-4530.2008.00243.x)

Book Sections

Aggarwal, A. and Sacks, M. S. (2015) A framework for determination of heart valves’ mechanical properties using inverse-modeling approach. In: van Assen, H., Bovendeerd, P. and Delhaas, T. (eds.) Functional Imaging and Modeling of the Heart. Series: Lecture notes in computer science (9126). Springer, pp. 285-294. (doi:10.1007/978-3-319-20309-6_33)

Lee, C.-H., Amini, R., Sakamoto, Y., Carruthers, C. A., Aggarwal, A. , Gorman, R. C., Gorman, J. H. and Sacks, M. S. (2015) Mitral valves: a computational framework. In: De, S., Hwang, W. and Kuhl, E. (eds.) Multiscale Modeling in Biomechanics and Mechanobiology. Springer: London, pp. 223-255. ISBN 9781447165989 (doi:10.1007/978-1-4471-6599-6_10)

Aggarwal, A. , Aguilar, V. S., Lee, C.-H., Ferrari, G., Gorman, J. H., Gorman, R. C. and Sacks, M. S. (2013) Patient-specific modeling of heart valves: From image to simulation. In: Ourselin, S., Rueckert, D. and Smith, N. (eds.) Functional Imaging and Modeling of the Heart. Series: Lecture notes in computer science (7945). Springer, pp. 141-149. ISBN 9783642388989 (doi:10.1007/978-3-642-38899-6_17)

Conference Proceedings

Aggarwal, A. and Sacks, M.S. (2014) In-vivo Assessment of Valvular Function: an Inverse Modeling Approach. In: Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014, Barcelona, Spain, 20-25 July 2014, ISBN 9788494284472

Aggarwal, A. and Sacks, M. S. (2014) Parameter Estimation of Heart Valve Leaflet Hyperelastic Mechanical Behavior Using an Inverse Modeling Approach. In: 2014 40th Annual Northeast Bioengineering Conference (NEBEC), Boston, MA., 25-27 Apr 2014, pp. 1-2. ISBN 978-1-4799-3728-8 (doi:10.1109/NEBEC.2014.6972704)

Aggarwal, A. , Aguilar, V.S., Lee, C.H., Ferrari, G., Gorman, J.H., Gorman, R.C. and Sacks, M.S. (2013) Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves. In: ASME 2013 Summer Bioengineering Conference, SBC 2013, Sunriver, Oregon, 26-29 June 2013, V01AT04A006. (doi:10.1115/SBC2013-14265)

This list was generated on Wed Apr 24 13:48:59 2019 BST.