Professor Rachel Myles

  • Professor (Cardiovascular & Metabolic Health)

email: Rachel.Myles@glasgow.ac.uk

RC342 Level C3, Institute of C&MS, Bhf Gcrc, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-4670-361X

Biography

Rachel is a clinician-scientist interested in ventricular arrhythmia mechanisms and the inherited cardiac conditions which cause sudden arrhythmic death. She trained in medicine at the University of Oxford, gaining a first-class degree in Physiological Sciences, and then at Guy’s and St. Thomas’. She moved to Glasgow in 2004 to undertake a PhD during which she trained in experimental electrophysiology with Professor Godfrey Smith. Rachel was appointed Clinical Lecturer after her PhD and has combined clinical and experimental research since then. She undertook a post-doctoral research fellowship at the University of California, Davis before securing a Wellcome Trust Intermediate Fellowship to establish her independent research lab.

Rachel is now a Professor of Cardiac Electrophysiology in the School of Cardiovascular and Metabolic Health at the University of Glasgow, and an Honorary Consultant Cardiologist in the West of Scotland Inherited Cardiac Conditions (WoSICC) Service. Her group’s research focuses on understanding the role of cellular behaviours in ventricular arrhythmia mechanisms in the whole heart, with the aim of identifying new therapeutic targets and better risk stratification tools for patients at risk of sudden arrhythmic death. Rachel’s clinical expertise is in the inherited arrhythmia syndromes, management of arrhythmias in cardiomyopathy and evaluation of patients and families affected by cardiac arrest and sudden arrhythmic death.

Research interests

Research Theme: Cardiac Diseases 

My current research approach combines both clinical and laboratory-based research, which utilizes optical imaging techniques to record voltage signals from intact myocardium in order to investigate the mechanisms of ventricular arrhythmias and sudden death in heart failure.

Research: Ventricular Arrhythmia Mechanisms

Research groups

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 37.

2025

Simitev, Radostin D. ORCID logoORCID: https://orcid.org/0000-0002-2207-5789, Gilchrist, Rebecca J. ORCID logoORCID: https://orcid.org/0000-0001-5003-4362, Yang, Zhechao, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, Francis L. and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2025) A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes. Royal Society Open Science, 12(3), 241539. (doi: 10.1098/rsos.241539) (PMID:29515888) (PMCID:PMC5830777)

Huethorst, Eline ORCID logoORCID: https://orcid.org/0000-0003-1900-4039, Bishop, Martin J., Burton, Francis L., Denning, Chris, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2025) Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium. Cardiovascular Research, (doi: 10.1093/cvr/cvaf034) (PMID:40036828) (Early Online Publication)

2024

Shead, Kyle D., Huethorst, Eline ORCID logoORCID: https://orcid.org/0000-0003-1900-4039, Burton, Francis, Lang, Ninian ORCID logoORCID: https://orcid.org/0000-0001-8441-6887, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2024) Human induced pluripotent stem cell-derived cardiomyocytes for preclinical cardiotoxicity screening in cardio-oncology. JACC: CardioOncology, 6(5), pp. 678-683. (doi: 10.1016/j.jaccao.2024.07.012) (PMID:39479327) (PMCID:PMC11520213)

Freeman, Michael, Huethorst, Eline ORCID logoORCID: https://orcid.org/0000-0003-1900-4039, Boland, Erin, Dunne, Michael, Burton, Francis, Denning, Chris, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)

2023

Simitev, Radostin D. ORCID logoORCID: https://orcid.org/0000-0002-2207-5789, Al dawoud, Antesar, Aziz, Muhamad H.N., Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. Mathematical Medicine and Biology, 40(2), pp. 175-198. (doi: 10.1093/imammb/dqad001) (PMID:36689769)

Mooney, Leanne, Jackson, Colette E., Adamson, Carly, McConnachie, Alex ORCID logoORCID: https://orcid.org/0000-0002-7262-7000, Welsh, Paul ORCID logoORCID: https://orcid.org/0000-0002-7970-3643, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, McMurray, John J.V. ORCID logoORCID: https://orcid.org/0000-0002-6317-3975, Jhund, Pardeep S. ORCID logoORCID: https://orcid.org/0000-0003-4306-5317, Petrie, Mark C. ORCID logoORCID: https://orcid.org/0000-0002-6333-9496 and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2023) Adverse outcomes associated with interleukin-6 in patients recently hospitalized for heart failure with preserved ejection fraction. Circulation: Heart Failure, 16(4), e010051. (doi: 10.1161/CIRCHEARTFAILURE.122.010051) (PMID:36896709) (PMCID:PMC10101136)

Alexander, Cherry, Bishop, Martin J., Gilchrist, Rebecca J. ORCID logoORCID: https://orcid.org/0000-0001-5003-4362, Burton, Francis L., Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)

2022

Saxena, Priyanka, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Workman, Antony J. ORCID logoORCID: https://orcid.org/0000-0002-5429-8303 (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)

Lachaud, Quentin, Aziz, Muhamad Hifzhudin Noor, Burton, Francis L., Macquaide, Niall ORCID logoORCID: https://orcid.org/0000-0001-9026-0073, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Simitev, Radostin D. ORCID logoORCID: https://orcid.org/0000-0002-2207-5789 and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)

2021

Sveberg Dietrichs, Erik, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117(12), e159-e161. (doi: 10.1093/cvr/cvab297) (PMID:34718465) (PMCID:PMC8562327)

Jabbour, R. J. et al. (2021) In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight, 6(15), e144068. (doi: 10.1172/jci.insight.144068) (PMID:34369384) (PMCID:PMC8410032)

Wang, Lianguo, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Lee, I-Ju, Bers, Donald M. and Ripplinger, Crystal M. (2021) Role of reduced sarco-endoplasmic reticulum Ca2+-ATPase function on sarcoplasmic reticulum Ca2+ alternans in the intact rabbit heart. Frontiers in Physiology, 12, 656516. (doi: 10.3389/fphys.2021.656516) (PMID:34045974) (PMCID:PMC8144333)

Dobbin, Stephen J.H. ORCID logoORCID: https://orcid.org/0000-0002-9111-0242, Petrie, Mark C. ORCID logoORCID: https://orcid.org/0000-0002-6333-9496, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135(1), pp. 71-100. (doi: 10.1042/CS20200305) (PMID:33404052) (PMCID:PMC7812690)

2020

Dietrichs, Erik S., McGlynn, Karen, Allan, Andrew, Connolly, Adam, Bishop, Martin, Burton, Francis, Kettlewell, Sarah, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Tveita, Torkjel and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

Dietrichs, Erik Sveberg, Tveita, Torkjel, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2020) A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, 27. (doi: 10.1186/s13049-020-00721-0) (PMID:32276599) (PMCID:PMC7149849)

2019

Wang, L. et al. (2019) Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. Journal of Physiology, 597(15), pp. 3867-3883. (doi: 10.1113/jp278016) (PMID:31215643)

Kettlewell, Sarah, Saxena, Priyanka, Dempster, John, Colman, Michael A., Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Workman, Antony J. ORCID logoORCID: https://orcid.org/0000-0002-5429-8303 (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)

2018

Connolly, Adam, Kelly, Allen, Campos, Fernando O., Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Bishop, Martin J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period. Biophysical Journal, 115(12), pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003) (PMID:30503533) (PMCID:PMC6301915)

2017

Murphy, Shannon R., Wang, Lianguo, Wang, Zhen, Domondon, Philip, Lang, Di, Habecker, Beth A., Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Ripplinger, Crystal M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia. Frontiers in Physiology, 8, 630. (doi: 10.3389/fphys.2017.00630) (PMID:28894423) (PMCID:PMC5581400)

2016

Gardner, Ryan T., Ripplinger, Crystal M., Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Habecker, Beth A. (2016) Molecular mechanisms of sympathetic remodeling and arrhythmias. Circulation: Arrhythmia and Electrophysiology, 9(2), e001359. (doi: 10.1161/circep.115.001359) (PMID:26810594) (PMCID:PMC4730917)

2015

Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Wang, Lianguo, Bers, Donald M. and Ripplinger, Crystal M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593(6), pp. 1479-1493. (doi: 10.1113/jphysiol.2014.279638) (PMID:25772297)

2014

Wang, Lianguo, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, De Jesus, Nicole M., Ohlendorf, Alex K.P., Bers, Donald M. and Ripplinger, Crystal M. (2014) Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation Research, 114(9), pp. 1410-1421. (doi: 10.1161/CIRCRESAHA.114.302505)

Jackson, Colette E., Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and McMurray, John J.V. ORCID logoORCID: https://orcid.org/0000-0002-6317-3975 (2014) Microvolt T-wave alternans testing in patients recently hospitalized with decompensated heart failure. European Journal of Heart Failure, 16(1), p. 113. (doi: 10.1111/ejhf.45) (PMID:24453101)

2013

Di Diego, J.M., Sicouri, S., Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, FL., Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi: 10.1093/eurjhf/hfs050)

Kelly, A., Ghouri, I.A., Kemi, O.J. ORCID logoORCID: https://orcid.org/0000-0003-1344-9512, Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

2012

Jackson, C.E., Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Cobbe, S.M., Petrie, M.C. ORCID logoORCID: https://orcid.org/0000-0002-6333-9496 and McMurray, J.J.V. ORCID logoORCID: https://orcid.org/0000-0002-6317-3975 (2012) Microvolt T-wave alternans testing has no role at present in guiding therapy for patients at high risk of ventricular arrhythmias. Journal of the American College of Cardiology, 59(9), p. 856. (doi: 10.1016/j.jacc.2011.10.897)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi: 10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi: 10.1093/eurjhf/hfs010)

Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Wang, L., Kang, C., Bers, D.M. and Ripplinger, C.M. (2012) Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research, 110(11), pp. 1454-1464. (doi: 10.1161/CIRCRESAHA.111.262345)

Seegers, J. et al. (2012) Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace, 14(3), pp. 416-422. (doi: 10.1093/europace/eur352)

2011

Myles, R. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

2010

Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

2009

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S. and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi: 10.1093/eurjhf/hfp157)

2008

Lang, N.N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887, Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

This list was generated on Sun Jun 15 04:24:40 2025 BST.
Jump to: Articles
Number of items: 37.

Articles

Simitev, Radostin D. ORCID logoORCID: https://orcid.org/0000-0002-2207-5789, Gilchrist, Rebecca J. ORCID logoORCID: https://orcid.org/0000-0001-5003-4362, Yang, Zhechao, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, Francis L. and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2025) A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes. Royal Society Open Science, 12(3), 241539. (doi: 10.1098/rsos.241539) (PMID:29515888) (PMCID:PMC5830777)

Huethorst, Eline ORCID logoORCID: https://orcid.org/0000-0003-1900-4039, Bishop, Martin J., Burton, Francis L., Denning, Chris, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2025) Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium. Cardiovascular Research, (doi: 10.1093/cvr/cvaf034) (PMID:40036828) (Early Online Publication)

Shead, Kyle D., Huethorst, Eline ORCID logoORCID: https://orcid.org/0000-0003-1900-4039, Burton, Francis, Lang, Ninian ORCID logoORCID: https://orcid.org/0000-0001-8441-6887, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2024) Human induced pluripotent stem cell-derived cardiomyocytes for preclinical cardiotoxicity screening in cardio-oncology. JACC: CardioOncology, 6(5), pp. 678-683. (doi: 10.1016/j.jaccao.2024.07.012) (PMID:39479327) (PMCID:PMC11520213)

Freeman, Michael, Huethorst, Eline ORCID logoORCID: https://orcid.org/0000-0003-1900-4039, Boland, Erin, Dunne, Michael, Burton, Francis, Denning, Chris, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)

Simitev, Radostin D. ORCID logoORCID: https://orcid.org/0000-0002-2207-5789, Al dawoud, Antesar, Aziz, Muhamad H.N., Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. Mathematical Medicine and Biology, 40(2), pp. 175-198. (doi: 10.1093/imammb/dqad001) (PMID:36689769)

Mooney, Leanne, Jackson, Colette E., Adamson, Carly, McConnachie, Alex ORCID logoORCID: https://orcid.org/0000-0002-7262-7000, Welsh, Paul ORCID logoORCID: https://orcid.org/0000-0002-7970-3643, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, McMurray, John J.V. ORCID logoORCID: https://orcid.org/0000-0002-6317-3975, Jhund, Pardeep S. ORCID logoORCID: https://orcid.org/0000-0003-4306-5317, Petrie, Mark C. ORCID logoORCID: https://orcid.org/0000-0002-6333-9496 and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2023) Adverse outcomes associated with interleukin-6 in patients recently hospitalized for heart failure with preserved ejection fraction. Circulation: Heart Failure, 16(4), e010051. (doi: 10.1161/CIRCHEARTFAILURE.122.010051) (PMID:36896709) (PMCID:PMC10101136)

Alexander, Cherry, Bishop, Martin J., Gilchrist, Rebecca J. ORCID logoORCID: https://orcid.org/0000-0001-5003-4362, Burton, Francis L., Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)

Saxena, Priyanka, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Workman, Antony J. ORCID logoORCID: https://orcid.org/0000-0002-5429-8303 (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)

Lachaud, Quentin, Aziz, Muhamad Hifzhudin Noor, Burton, Francis L., Macquaide, Niall ORCID logoORCID: https://orcid.org/0000-0001-9026-0073, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Simitev, Radostin D. ORCID logoORCID: https://orcid.org/0000-0002-2207-5789 and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)

Sveberg Dietrichs, Erik, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117(12), e159-e161. (doi: 10.1093/cvr/cvab297) (PMID:34718465) (PMCID:PMC8562327)

Jabbour, R. J. et al. (2021) In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight, 6(15), e144068. (doi: 10.1172/jci.insight.144068) (PMID:34369384) (PMCID:PMC8410032)

Wang, Lianguo, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Lee, I-Ju, Bers, Donald M. and Ripplinger, Crystal M. (2021) Role of reduced sarco-endoplasmic reticulum Ca2+-ATPase function on sarcoplasmic reticulum Ca2+ alternans in the intact rabbit heart. Frontiers in Physiology, 12, 656516. (doi: 10.3389/fphys.2021.656516) (PMID:34045974) (PMCID:PMC8144333)

Dobbin, Stephen J.H. ORCID logoORCID: https://orcid.org/0000-0002-9111-0242, Petrie, Mark C. ORCID logoORCID: https://orcid.org/0000-0002-6333-9496, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135(1), pp. 71-100. (doi: 10.1042/CS20200305) (PMID:33404052) (PMCID:PMC7812690)

Dietrichs, Erik S., McGlynn, Karen, Allan, Andrew, Connolly, Adam, Bishop, Martin, Burton, Francis, Kettlewell, Sarah, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Tveita, Torkjel and Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

Dietrichs, Erik Sveberg, Tveita, Torkjel, Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2020) A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, 27. (doi: 10.1186/s13049-020-00721-0) (PMID:32276599) (PMCID:PMC7149849)

Wang, L. et al. (2019) Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. Journal of Physiology, 597(15), pp. 3867-3883. (doi: 10.1113/jp278016) (PMID:31215643)

Kettlewell, Sarah, Saxena, Priyanka, Dempster, John, Colman, Michael A., Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Smith, Godfrey L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Workman, Antony J. ORCID logoORCID: https://orcid.org/0000-0002-5429-8303 (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)

Connolly, Adam, Kelly, Allen, Campos, Fernando O., Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Smith, Godfrey ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Bishop, Martin J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period. Biophysical Journal, 115(12), pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003) (PMID:30503533) (PMCID:PMC6301915)

Murphy, Shannon R., Wang, Lianguo, Wang, Zhen, Domondon, Philip, Lang, Di, Habecker, Beth A., Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Ripplinger, Crystal M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia. Frontiers in Physiology, 8, 630. (doi: 10.3389/fphys.2017.00630) (PMID:28894423) (PMCID:PMC5581400)

Gardner, Ryan T., Ripplinger, Crystal M., Myles, Rachel ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and Habecker, Beth A. (2016) Molecular mechanisms of sympathetic remodeling and arrhythmias. Circulation: Arrhythmia and Electrophysiology, 9(2), e001359. (doi: 10.1161/circep.115.001359) (PMID:26810594) (PMCID:PMC4730917)

Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Wang, Lianguo, Bers, Donald M. and Ripplinger, Crystal M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593(6), pp. 1479-1493. (doi: 10.1113/jphysiol.2014.279638) (PMID:25772297)

Wang, Lianguo, Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, De Jesus, Nicole M., Ohlendorf, Alex K.P., Bers, Donald M. and Ripplinger, Crystal M. (2014) Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation Research, 114(9), pp. 1410-1421. (doi: 10.1161/CIRCRESAHA.114.302505)

Jackson, Colette E., Myles, Rachel C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X and McMurray, John J.V. ORCID logoORCID: https://orcid.org/0000-0002-6317-3975 (2014) Microvolt T-wave alternans testing in patients recently hospitalized with decompensated heart failure. European Journal of Heart Failure, 16(1), p. 113. (doi: 10.1111/ejhf.45) (PMID:24453101)

Di Diego, J.M., Sicouri, S., Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, FL., Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi: 10.1093/eurjhf/hfs050)

Kelly, A., Ghouri, I.A., Kemi, O.J. ORCID logoORCID: https://orcid.org/0000-0003-1344-9512, Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

Jackson, C.E., Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Cobbe, S.M., Petrie, M.C. ORCID logoORCID: https://orcid.org/0000-0002-6333-9496 and McMurray, J.J.V. ORCID logoORCID: https://orcid.org/0000-0002-6317-3975 (2012) Microvolt T-wave alternans testing has no role at present in guiding therapy for patients at high risk of ventricular arrhythmias. Journal of the American College of Cardiology, 59(9), p. 856. (doi: 10.1016/j.jacc.2011.10.897)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi: 10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi: 10.1093/eurjhf/hfs010)

Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Wang, L., Kang, C., Bers, D.M. and Ripplinger, C.M. (2012) Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research, 110(11), pp. 1454-1464. (doi: 10.1161/CIRCRESAHA.111.262345)

Seegers, J. et al. (2012) Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace, 14(3), pp. 416-422. (doi: 10.1093/europace/eur352)

Myles, R. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S. and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi: 10.1093/eurjhf/hfp157)

Lang, N.N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887, Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. ORCID logoORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID logoORCID: https://orcid.org/0000-0003-4821-9741 (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

This list was generated on Sun Jun 15 04:24:40 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Regulation of Ca(v)1.2 in cardiac health and disease
    British Heart Foundation
    2025 - 2030
     
  • Cross disciplinary capacity building in ultra-high frequency preclinical cardiovascular ultrasound
    British Heart Foundation
    2022 - 2025
     
  • Correlative Optical investiagtion of cardiac Eletrophysiology Under Remodelling
    British Heart Foundation
    2022 - 2025
     
  • Pharmacological and dynamic-clamp narrowing of the calcium current window to inhibit human atrial early after depolarisations and atrial fibrillation.
    British Heart Foundation
    2021 - 2024
     
  • Adrenergic modulation of ventricular conduction velocity is a novel modulator of electrical excitability in health and disease
    British Heart Foundation
    2019 - 2022
     
  • Investigating the influence of myofibroblast coupling on cardiac conduction and infarct electrophysiology
    British Heart Foundation
    2017 - 2020
     
  • Adrenoceptor-subtype antagonism profiles with anti-arrhythmic potential in human atrial myocytes
    British Heart Foundation
    2017 - 2020
     
  • The role of sarcoplasmic reticulum calcium in the generation of early after-depolarisations and ventricular arrhythmias in the long QT syndrome
    British Heart Foundation
    2015 - 2018
     
  • Heterogeneity of sympathetic stimulation as a mechanism of ventricular arrhythmia following myocardial infarction
    Wellcome Trust
    2015 - 2020
     
  • Mechanisms of Early Afterdepolarisations in the Long QT Syndrome: A Study of Cellular Voltage and Calcium Dynamics in the Intact Heart
    Academy of Medical Sciences
    2013 - 2015
     
  • Electrophysiological remodelling and mechanisms of ventricular arrhythmia in dilated cardiomyopathy.
    British Heart Foundation
    2010 - 2011
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Microvolt T-wave alternans in chronic heart failure: a study of prevalence and incremental prognostic value.
    Scottish Executive Health Department
    2007 - 2009
     
  • Microvolt T-wave alternans in chronic heart failure: a study of prevalence and incremental prognostic value.
    NHS Endowment Funds
    2007 - 2008
     
  • The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
    British Heart Foundation
    2006 - 2009
     

Supervision

  • Dickson-Murray, Eleanor
    Palmitoylation and the regulation of the cardiac transient outward current
  • Shead, Kyle
    Use of IPSCs as a novel platform to screen for cardiotoxicity in anti-cancer therapies

Research datasets

Jump to: 2025 | 2024 | 2023
Number of items: 3.

2025

Simitev, R. , Gilchrist, R. , Yang, Z., Myles, R. , Burton, F. and Smith, G. (2025) A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes. [Data Collection]

2024

Simitev, R. , Gilchrist, R. J., Burton, F. L., Myles, R. C. and Smith, G. L. (2024) Code and data for estimation of parameters in mathematical models of myocyte action potentials. [Data Collection]

2023

Simitev, R. D. , Al dawoud, A. M. A., Aziz, M. H. N., Myles, R. and Smith, G. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. [Data Collection]

This list was generated on Sun Jun 15 04:24:41 2025 BST.

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