School of Cardiovascular & Metabolic Health

Dr Laura Dowsett

  • Research Fellow (Cardiovascular & Metabolic Health)

Biography

Dr Laura Dowsett is a Research Fellow at the BHF Glasgow Cardiovascular Research Centre. Laura first graduated from the University of Manchester with a BSc in Pharmacology and Physiology with Industrial Experience (Drug Metabolism Group, Sanofi Aventis). Following this Laura joined the MRC Clinical Science Centre, Imperial College London where she completed her PhD under the supervision of Dr James Leiper. This research focused on understanding the role of the Dimethylarginine dimethylaminohydrolase (DDAH) enzymes and the cardiovascular risk factor ‘ADMA’ in adipocytes and endothelial cells in models of diet induced obesity. Laura’s first post-doctoral position was based at UCL’s Institute of Ophthalmology investigating endothelial cell signalling and models of angiogenesis in retinal disease and cancer progression.

In 2017 Laura rejoined the Leiper Lab as it moved to the University of Glasgow. Here Laura continued to expand her previous work investigating the interaction between ADMA and the Calcium Sensing receptor. Laura is now developing her own research group, continuing her interest in the Calcium sensing receptor in cardiometabolic disease. Other current research interests include adipose-vascular crosstalk, endothelial cell heterogeneity and models of obesity and diabetes. 

Research interests

Research Theme: Vascular Diseases and Comorbidities

Research groups

Publications

List by: Type | Date

Jump to: 2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2015 | 2013 | 2012
Number of items: 11.

2026

Kamdar, A. et al. (2026) Proteomic insights into troponin elevation following COVID-19 infection. Heart, (doi: 10.1136/heartjnl-2025-326786) (Early Online Publication)

2025

McAleese, C. ORCID logoORCID: https://orcid.org/0000-0003-2756-4941, Joudah, G., Salt, I.P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724, Petrie, J.R. ORCID logoORCID: https://orcid.org/0000-0002-4894-9819, Leiper, J.M. ORCID logoORCID: https://orcid.org/0000-0003-4656-519X and Dowsett, Laura B. ORCID logoORCID: https://orcid.org/0000-0002-3356-8183 (2025) Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin. Journal of Physiology, (doi: 10.1113/JP288006) (PMID:39998029) (Early Online Publication)

2024

Riddell, Alexandra ORCID logoORCID: https://orcid.org/0000-0003-4566-8680, Flynn, Arun, Bergugnat, Hugo, Dowsett, Laura B. ORCID logoORCID: https://orcid.org/0000-0002-3356-8183 and Miller, Alyson A. ORCID logoORCID: https://orcid.org/0000-0001-7755-9046 (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138(20), pp. 1305-1323. (doi: 10.1042/CS20241021)

2023

Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Duluc, Lucie, Higgins, Erin, Alghamdi, Fatmah, Fast, Walter, Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 and Leiper, James ORCID logoORCID: https://orcid.org/0000-0003-4656-519X (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

2022

Dritsoula, Athina, Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Pilotti, Camilla, O'Connor, Marie N., Moss, Stephen E. and Greenwood, John (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, 4867. (doi: 10.1038/s41598-022-08516-2) (PMID:35318338) (PMCID:PMC8938720)

2021

O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)

2020

Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Higgins, Erin, Alanazi, Sarah, Alshuwayer, Noha A., Leiper, Fiona C. ORCID logoORCID: https://orcid.org/0000-0001-6681-681X and Leiper, James ORCID logoORCID: https://orcid.org/0000-0003-4656-519X (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

2015

Dowsett, L. et al. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

2013

Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

2012

Caplin, Ben, Wang, Zhen, Slaviero, Anna, Tomlinson, James, Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Delahaye, Mathew, Salama, Alan, Wheeler, David C. and Leiper, James ORCID logoORCID: https://orcid.org/0000-0003-4656-519X (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

This list was generated on Sun May 10 10:31:57 2026 BST.
Jump to: Articles
Number of items: 11.

Articles

Kamdar, A. et al. (2026) Proteomic insights into troponin elevation following COVID-19 infection. Heart, (doi: 10.1136/heartjnl-2025-326786) (Early Online Publication)

McAleese, C. ORCID logoORCID: https://orcid.org/0000-0003-2756-4941, Joudah, G., Salt, I.P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724, Petrie, J.R. ORCID logoORCID: https://orcid.org/0000-0002-4894-9819, Leiper, J.M. ORCID logoORCID: https://orcid.org/0000-0003-4656-519X and Dowsett, Laura B. ORCID logoORCID: https://orcid.org/0000-0002-3356-8183 (2025) Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin. Journal of Physiology, (doi: 10.1113/JP288006) (PMID:39998029) (Early Online Publication)

Riddell, Alexandra ORCID logoORCID: https://orcid.org/0000-0003-4566-8680, Flynn, Arun, Bergugnat, Hugo, Dowsett, Laura B. ORCID logoORCID: https://orcid.org/0000-0002-3356-8183 and Miller, Alyson A. ORCID logoORCID: https://orcid.org/0000-0001-7755-9046 (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138(20), pp. 1305-1323. (doi: 10.1042/CS20241021)

Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Duluc, Lucie, Higgins, Erin, Alghamdi, Fatmah, Fast, Walter, Salt, Ian P. ORCID logoORCID: https://orcid.org/0000-0003-0055-3724 and Leiper, James ORCID logoORCID: https://orcid.org/0000-0003-4656-519X (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

Dritsoula, Athina, Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Pilotti, Camilla, O'Connor, Marie N., Moss, Stephen E. and Greenwood, John (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, 4867. (doi: 10.1038/s41598-022-08516-2) (PMID:35318338) (PMCID:PMC8938720)

O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)

Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Higgins, Erin, Alanazi, Sarah, Alshuwayer, Noha A., Leiper, Fiona C. ORCID logoORCID: https://orcid.org/0000-0001-6681-681X and Leiper, James ORCID logoORCID: https://orcid.org/0000-0003-4656-519X (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

Dowsett, L. et al. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

Caplin, Ben, Wang, Zhen, Slaviero, Anna, Tomlinson, James, Dowsett, Laura ORCID logoORCID: https://orcid.org/0000-0002-3356-8183, Delahaye, Mathew, Salama, Alan, Wheeler, David C. and Leiper, James ORCID logoORCID: https://orcid.org/0000-0003-4656-519X (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

This list was generated on Sun May 10 10:31:57 2026 BST.

Teaching

As a Research Fellow the majority of Laura’s teaching comes in the form of mentoring BSc, MSc and PhD students through their laboratory-based projects.

Laura also delivers formal lectures for the MSc Cardiovascular Sciences course.


Dr Laura Dowsett