Dr Laura Dowsett

  • Research Fellow (Cardiovascular & Metabolic Health)

Research interests

Research Theme: Vascular Diseases and Comorbidities

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2015 | 2013 | 2012
Number of items: 9.

2024

Riddell, A. , Flynn, A., Bergugnat, H., Dowsett, L. B. and Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, (Accepted for Publication)

2023

Dowsett, L. , Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P. and Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

2022

Dritsoula, A., Dowsett, L. , Pilotti, C., O'Connor, M. N., Moss, S. E. and Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, 4867. (doi: 10.1038/s41598-022-08516-2) (PMID:35318338) (PMCID:PMC8938720)

2021

O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)

2020

Dowsett, L. , Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C. and Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

2015

Dowsett, L. et al. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

2013

Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

2012

Caplin, B., Wang, Z., Slaviero, A., Tomlinson, J., Dowsett, L. , Delahaye, M., Salama, A., Wheeler, D. C. and Leiper, J. (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

This list was generated on Wed Oct 9 15:48:26 2024 BST.
Jump to: Articles
Number of items: 9.

Articles

Riddell, A. , Flynn, A., Bergugnat, H., Dowsett, L. B. and Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, (Accepted for Publication)

Dowsett, L. , Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P. and Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

Dritsoula, A., Dowsett, L. , Pilotti, C., O'Connor, M. N., Moss, S. E. and Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, 4867. (doi: 10.1038/s41598-022-08516-2) (PMID:35318338) (PMCID:PMC8938720)

O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)

Dowsett, L. , Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C. and Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

Dowsett, L. et al. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

Caplin, B., Wang, Z., Slaviero, A., Tomlinson, J., Dowsett, L. , Delahaye, M., Salama, A., Wheeler, D. C. and Leiper, J. (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

This list was generated on Wed Oct 9 15:48:26 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Reducing with Metformin Adverse Vascular Lesions (REMOVAL) Trial Follow-up - Identifying those at risk of Type 1 Diabetes-associated vascular complications
    The Novo Nordisk UK Research Foundation
    2024 - 2024
     
  • Investigating calcium-sensing receptor mediated sex differences in cardiometabolic disease
    British Heart Foundation
    2024 - 2027
     
  • Asymmetric dimethylarginine signalling via the calcium sensing receptor in the vascular and metabolic complications of type 2 diabetes
    British Heart Foundation
    2021 - 2024
     
  • Using the Endo-Ribotag mouse to identify targtes of ADMA in vascular disease
    Rosetrees Trust
    2019 - 2020
     

Supervision