Dr Antony Workman

  • Senior Lecturer (Cardiovascular & Metabolic Health)

telephone: 01413303451
email: Antony.Workman@glasgow.ac.uk

Room C342, Institute of Cardiovascular & Medical Sciences, BHF-GCRC 126 University Place, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-5429-8303

Biography

● BSc Animal Physiology, London University (1988).

● PhD Cardiovascular Pharmacology, De Montfort University, Leicester (1996).

● Postdoctoral Research Fellow, University of Glasgow (1996).

● British Heart Foundation Basic Science Lectureship, University of Glasgow (2001-2005).

● Lecturer, University of Glasgow (2001).

● Postgraduate Certificate in Academic Practice, Glasgow (2004).

● British Heart Foundation Basic Science Lectureship Renewal, University of Glasgow (2006-2011).

● Secured tenured post, University of Glasgow (2006).

● Senior Lecturer, University of Glasgow (2010).

 

Research interests

Member: Cardiac

Atrial fibrillation (AF) is a disorder of the rhythm of the heart's upper chambers. This disease affects ~1% of the general population, and decreases their life expectancy. My research aims to improve our understanding of the electrophysiological and molecular mechanisms of AF, in the hope that this will lead to more effective treatments.

Research: Human atrial fibrillation

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003 | 2001 | 2000 | 1999 | 1998 | 1997
Number of items: 38.

2023

Giommi, A., Gurgel, A. R. B., Smith, G. L. and Workman, A. J. (2023) Does the small conductance Ca2+-activated K+ current ISK flow under physiological conditions in rabbit and human atrial isolated cardiomyocytes? Journal of Molecular and Cellular Cardiology, 183, pp. 70-80. (doi: 10.1016/j.yjmcc.2023.09.002) (PMID:37704101)

2022

Saxena, P., Myles, R. C. , Smith, G. L. and Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)

2021

Holmes, A. P. et al. (2021) The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone. Heart Rhythm, 18(7), pp. 1212-1220. (doi: 10.1016/j.hrthm.2021.03.016) (PMID:33737232)

2019

Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C. , Smith, G. L. and Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)

2018

Colman, M. A., Saxena, P., Kettlewell, S. and Workman, A. J. (2018) Description of the human atrial action potential derived from a single, congruent data source: novel computational models for integrated experimental-numerical study of atrial arrhythmia mechanisms. Frontiers in Physiology, 9, 1211. (doi: 10.3389/fphys.2018.01211) (PMID:30245635) (PMCID:PMC6137999)

2016

Pandit, S. V. and Workman, A. (2016) Atrial electrophysiological remodeling and fibrillation in heart failure. Clinical Medicine Insights: Cardiology, 10(Sup 1), pp. 41-46. (doi: 10.4137/CMC.S39713) (PMID:27812293) (PMCID:PMC5089851)

Colman, M. A., Sarathy, P. P., MacQuiaide, N. and Workman, A. J. (2016) A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation. Computing in Cardiology, 43, pp. 221-224. (doi: 10.23919/CIC.2016.7868719)

2015

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J. , Hancox, J. C. and Zhang, H. (2015) A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems: insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), e1004026. (doi: 10.1371/journal.pcbi.1004026) (PMID:25611350) (PMCID:PMC4303377)

2014

Kharche, S. R., Stary, T., Colman, M. A., Biktasheva, I. V., Workman, A. J. , Rankin, A. C., Holden, A. V. and Zhang, H. (2014) Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of AF: a computer simulation. Europace, 16(10), pp. 1524-1533. (doi: 10.1093/europace/euu084) (PMID:25085203) (PMCID:PMC4640177)

Marshall, G. E., Russell, J. A., Tellez, J. O., Jhund, P. S. , Currie, S., Dempster, J., Boyett, M. R., Kane, K. A., Rankin, A. C. and Workman, A. J. (2014) Erratum to: Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 466(5), p. 1021. (doi: 10.1007/s00424-014-1505-3)

2013

Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)

2012

Workman, A.J. , Marshall, G.E., Rankin, A.C., Smith, G.L. and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi: 10.1113/jphysiol.2012.235986)

Grandi, E., Workman, A.J. and Pandit, S.V. (2012) Altered excitation-contraction coupling in human chronic atrial fibrillation. Journal of Atrial Fibrillation, 2(10), pp. 1-17.

Marshall, G.E., Russell, J.A., Tellez, J.O., Jhund, P.S. , Currie, S., Dempster, J., Boyett, M.R., Kane, K.A., Rankin, A.C. and Workman, A.J. (2012) Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 463(4), pp. 537-548. (doi: 10.1007/s00424-011-1061-z)

2011

Pandit, S.V. et al. (2011) Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs. Cardiovascular Research, 89(4), pp. 843-851. (doi: 10.1093/cvr/cvq359) (PMID:21076156) (PMCID:PMC3306132)

Grandi, E., Pandit, S.V., Voigt, N., Workman, A.J. , Dobrev, D., Jalife, J. and Bers, D.M. (2011) Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation Research, 109(9), pp. 1055-1066. (doi: 10.1161/CIRCRESAHA.111.253955)

Workman, A.J. , Smith, G.L. and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi: 10.1016/j.pharmthera.2011.02.002)

2010

Workman, A.J. and Rankin, A.C. (2010) Do hypoxemia or hypercapnia predispose to atrial fibrillation in breathing disorders, and, if so, how? Heart Rhythm, 7(9), pp. 1271-1272. (doi: 10.1016/j.hrthm.2010.04.004)

Workman, A.J. (2010) Cardiac adrenergic control and atrial fibrillation. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(3), pp. 235-249. (doi: 10.1007/s00210-009-0474-0)

2009

Rankin, A.C. and Workman, A.J. (2009) Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? Cardiovascular Research, 84(2), pp. 180-181. (doi: 10.1093/cvr/cvp299) (PMID:19713283) (PMCID:PMC2762576)

Workman, A.J. (2009) Mechanisms of postcardiac surgery atrial fibrillation: more pieces in a difficult puzzle. Heart Rhythm, 6(10), pp. 1423-1424. (doi: 10.1016/j.hrthm.2009.07.031)

Workman, A.J., Pau, D., Redpath, C., Marshall, G.E., Russell, J.A., Norrie, J., Kane, K.A. and Rankin, A.C. (2009) Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF. Heart Rhythm, 6(4), pp. 445-451. (doi: 10.1016/j.hrthm.2008.12.028)

2008

Workman, A.J. , Kane, K. and Rankin, A.C. (2008) Cellular bases for human atrial fibrillation. Heart Rhythm, 5(6, Sup), S1-S6. (doi: 10.1016/j.hrthm.2008.01.016)

2007

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2007) Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation. Journal of Molecular and Cellular Cardiology, 42(1), pp. 54-62. (doi: 10.1016/j.yjmcc.2006.08.007)

2006

Workman, A.J., Pau, D., Redpath, C.J., Marshall, G.E., Russell, J.A., Kane, K.A., Norrie, J. and Rankin, A.C. (2006) Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology. Journal of Cardiovascular Electrophysiology, 17(11), pp. 1230-1238. (doi: 10.1111/j.1540-8167.2006.00592.x)

Redpath, C., Rankin, A.C., Kane, K.A. and Workman, A.J. (2006) Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic. Journal of Molecular and Cellular Cardiology, 40(5), pp. 717-724. (doi: 10.1016/j.yjmcc.2006.01.012)

2005

Pau, D., Workman, A.J. , Kane, K.A. and Rankin, A.C. (2005) Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. Journal of Pharmacology and Experimental Therapeutics, 313, pp. 146-153. (doi: 10.1124/jpet.104.076869)

2003

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade. British Journal of Pharmacology, 140, pp. 1434-1441. (doi: 10.1038/sj.bjp.0705553)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation. Cardiovascular Research, 59(3), pp. 593-602. (doi: 10.1016/S0008-6363(03)00466-8)

Workman, A.J., Kane, K.A., Russell, J.A., Norrie, J. and Rankin, A.C. (2003) Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. Cardiovascular Research, 58(3), pp. 518-525. (doi: 10.1016/S0008-6363(03)00263-3)

2001

Workman, A.J. , MacKenzie, I. and Northover, B.J. (2001) A KATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-83. (doi: 10.1016/S0014-2999(01)00972-4)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2001) The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular Research, 52(2), pp. 226-235. (doi: 10.1016/S0008-6363(01)00380-7)

Workman, A.J. , MacKenzie, I. and Northover, B.J. (2001) A K ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-78. (doi: 10.1016/S0014-2999(01)00972-4)

2000

Workman, A.J., Kane, K.A. and Rankin, A.C. (2000) Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium. Journal of Molecular and Cellular Cardiology, 32(8), pp. 1525-1537. (doi: 10.1006/jmcc.2000.1186)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2000) Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? Basic Research in Cardiology, 95(3), pp. 250-260. (doi: 10.1007/s003950050188)

1999

Workman, A.J., Kane, K.A. and Rankin, A.C. (1999) Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes. Cardiovascular Research, 43(4), pp. 974-984. (doi: 10.1016/S0008-6363(99)00166-2)

1998

Workman, A.J. and Rankin, A.C. (1998) Serotonin, If and human atrial arrhythmia. Cardiovascular Research, 40(3), p. 436. (doi: 10.1016/S0008-6363(98)00258-2)

1997

Rankin, A.C., Martynyuk,, A.E., Workman, A.J. and Kane, K.A. (1997) Ionic mechanisms of the effect of adenosine on single rabbit atrioventricular node myocytes. Canadian Journal of Cardiology, 13(12), pp. 1183-1187.

This list was generated on Sat Sep 23 12:40:27 2023 BST.
Jump to: Articles
Number of items: 38.

Articles

Giommi, A., Gurgel, A. R. B., Smith, G. L. and Workman, A. J. (2023) Does the small conductance Ca2+-activated K+ current ISK flow under physiological conditions in rabbit and human atrial isolated cardiomyocytes? Journal of Molecular and Cellular Cardiology, 183, pp. 70-80. (doi: 10.1016/j.yjmcc.2023.09.002) (PMID:37704101)

Saxena, P., Myles, R. C. , Smith, G. L. and Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)

Holmes, A. P. et al. (2021) The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone. Heart Rhythm, 18(7), pp. 1212-1220. (doi: 10.1016/j.hrthm.2021.03.016) (PMID:33737232)

Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C. , Smith, G. L. and Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)

Colman, M. A., Saxena, P., Kettlewell, S. and Workman, A. J. (2018) Description of the human atrial action potential derived from a single, congruent data source: novel computational models for integrated experimental-numerical study of atrial arrhythmia mechanisms. Frontiers in Physiology, 9, 1211. (doi: 10.3389/fphys.2018.01211) (PMID:30245635) (PMCID:PMC6137999)

Pandit, S. V. and Workman, A. (2016) Atrial electrophysiological remodeling and fibrillation in heart failure. Clinical Medicine Insights: Cardiology, 10(Sup 1), pp. 41-46. (doi: 10.4137/CMC.S39713) (PMID:27812293) (PMCID:PMC5089851)

Colman, M. A., Sarathy, P. P., MacQuiaide, N. and Workman, A. J. (2016) A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation. Computing in Cardiology, 43, pp. 221-224. (doi: 10.23919/CIC.2016.7868719)

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J. , Hancox, J. C. and Zhang, H. (2015) A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems: insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), e1004026. (doi: 10.1371/journal.pcbi.1004026) (PMID:25611350) (PMCID:PMC4303377)

Kharche, S. R., Stary, T., Colman, M. A., Biktasheva, I. V., Workman, A. J. , Rankin, A. C., Holden, A. V. and Zhang, H. (2014) Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of AF: a computer simulation. Europace, 16(10), pp. 1524-1533. (doi: 10.1093/europace/euu084) (PMID:25085203) (PMCID:PMC4640177)

Marshall, G. E., Russell, J. A., Tellez, J. O., Jhund, P. S. , Currie, S., Dempster, J., Boyett, M. R., Kane, K. A., Rankin, A. C. and Workman, A. J. (2014) Erratum to: Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 466(5), p. 1021. (doi: 10.1007/s00424-014-1505-3)

Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)

Workman, A.J. , Marshall, G.E., Rankin, A.C., Smith, G.L. and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi: 10.1113/jphysiol.2012.235986)

Grandi, E., Workman, A.J. and Pandit, S.V. (2012) Altered excitation-contraction coupling in human chronic atrial fibrillation. Journal of Atrial Fibrillation, 2(10), pp. 1-17.

Marshall, G.E., Russell, J.A., Tellez, J.O., Jhund, P.S. , Currie, S., Dempster, J., Boyett, M.R., Kane, K.A., Rankin, A.C. and Workman, A.J. (2012) Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 463(4), pp. 537-548. (doi: 10.1007/s00424-011-1061-z)

Pandit, S.V. et al. (2011) Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs. Cardiovascular Research, 89(4), pp. 843-851. (doi: 10.1093/cvr/cvq359) (PMID:21076156) (PMCID:PMC3306132)

Grandi, E., Pandit, S.V., Voigt, N., Workman, A.J. , Dobrev, D., Jalife, J. and Bers, D.M. (2011) Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation Research, 109(9), pp. 1055-1066. (doi: 10.1161/CIRCRESAHA.111.253955)

Workman, A.J. , Smith, G.L. and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi: 10.1016/j.pharmthera.2011.02.002)

Workman, A.J. and Rankin, A.C. (2010) Do hypoxemia or hypercapnia predispose to atrial fibrillation in breathing disorders, and, if so, how? Heart Rhythm, 7(9), pp. 1271-1272. (doi: 10.1016/j.hrthm.2010.04.004)

Workman, A.J. (2010) Cardiac adrenergic control and atrial fibrillation. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(3), pp. 235-249. (doi: 10.1007/s00210-009-0474-0)

Rankin, A.C. and Workman, A.J. (2009) Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? Cardiovascular Research, 84(2), pp. 180-181. (doi: 10.1093/cvr/cvp299) (PMID:19713283) (PMCID:PMC2762576)

Workman, A.J. (2009) Mechanisms of postcardiac surgery atrial fibrillation: more pieces in a difficult puzzle. Heart Rhythm, 6(10), pp. 1423-1424. (doi: 10.1016/j.hrthm.2009.07.031)

Workman, A.J., Pau, D., Redpath, C., Marshall, G.E., Russell, J.A., Norrie, J., Kane, K.A. and Rankin, A.C. (2009) Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF. Heart Rhythm, 6(4), pp. 445-451. (doi: 10.1016/j.hrthm.2008.12.028)

Workman, A.J. , Kane, K. and Rankin, A.C. (2008) Cellular bases for human atrial fibrillation. Heart Rhythm, 5(6, Sup), S1-S6. (doi: 10.1016/j.hrthm.2008.01.016)

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2007) Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation. Journal of Molecular and Cellular Cardiology, 42(1), pp. 54-62. (doi: 10.1016/j.yjmcc.2006.08.007)

Workman, A.J., Pau, D., Redpath, C.J., Marshall, G.E., Russell, J.A., Kane, K.A., Norrie, J. and Rankin, A.C. (2006) Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology. Journal of Cardiovascular Electrophysiology, 17(11), pp. 1230-1238. (doi: 10.1111/j.1540-8167.2006.00592.x)

Redpath, C., Rankin, A.C., Kane, K.A. and Workman, A.J. (2006) Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic. Journal of Molecular and Cellular Cardiology, 40(5), pp. 717-724. (doi: 10.1016/j.yjmcc.2006.01.012)

Pau, D., Workman, A.J. , Kane, K.A. and Rankin, A.C. (2005) Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. Journal of Pharmacology and Experimental Therapeutics, 313, pp. 146-153. (doi: 10.1124/jpet.104.076869)

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade. British Journal of Pharmacology, 140, pp. 1434-1441. (doi: 10.1038/sj.bjp.0705553)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation. Cardiovascular Research, 59(3), pp. 593-602. (doi: 10.1016/S0008-6363(03)00466-8)

Workman, A.J., Kane, K.A., Russell, J.A., Norrie, J. and Rankin, A.C. (2003) Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. Cardiovascular Research, 58(3), pp. 518-525. (doi: 10.1016/S0008-6363(03)00263-3)

Workman, A.J. , MacKenzie, I. and Northover, B.J. (2001) A KATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-83. (doi: 10.1016/S0014-2999(01)00972-4)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2001) The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular Research, 52(2), pp. 226-235. (doi: 10.1016/S0008-6363(01)00380-7)

Workman, A.J. , MacKenzie, I. and Northover, B.J. (2001) A K ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-78. (doi: 10.1016/S0014-2999(01)00972-4)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2000) Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium. Journal of Molecular and Cellular Cardiology, 32(8), pp. 1525-1537. (doi: 10.1006/jmcc.2000.1186)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2000) Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? Basic Research in Cardiology, 95(3), pp. 250-260. (doi: 10.1007/s003950050188)

Workman, A.J., Kane, K.A. and Rankin, A.C. (1999) Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes. Cardiovascular Research, 43(4), pp. 974-984. (doi: 10.1016/S0008-6363(99)00166-2)

Workman, A.J. and Rankin, A.C. (1998) Serotonin, If and human atrial arrhythmia. Cardiovascular Research, 40(3), p. 436. (doi: 10.1016/S0008-6363(98)00258-2)

Rankin, A.C., Martynyuk,, A.E., Workman, A.J. and Kane, K.A. (1997) Ionic mechanisms of the effect of adenosine on single rabbit atrioventricular node myocytes. Canadian Journal of Cardiology, 13(12), pp. 1183-1187.

This list was generated on Sat Sep 23 12:40:27 2023 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Pharmacological and dynamic-clamp narrowing of the calcium current window to inhibit human atrial early after depolarisations and atrial fibrillation.
    British Heart Foundation
    2021 - 2024
     
  • Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarction
    British Heart Foundation
    2017 - 2020
     
  • Adrenoceptor-subtype antagonism profiles with anti-arrhythmic potential in human atrial myocytes
    British Heart Foundation
    2017 - 2020
     
  • Afib-TrainNet
    European Commission
    2015 - 2019
     
  • Human atrial action potential alternans and afterdepolarisations: electrophysiological and calcium-cycling mechanisms and effects of myocardial disease
    British Heart Foundation
    2013 - 2017
     
  • Atrial remodelling of calcium handling and electrophysiology in heart failure.
    British Heart Foundation
    2009 - 2013
     
  • Atrial myocardial adaptation to prolonged beta-adrenoceptor antagonism in normal and failing hearts
    British Heart Foundation
    2006 - 2011
     
  • Human atrial cellular calcium handling, arrhythmogenic mechanisms of 5-hydroxytryptamine, and their modulation by atrial fibrillation
    British Heart Foundation
    2004 - 2007
     
  • Atrial fibrillation-induced ion currents and mRNA levels in the human atrium
    British Heart Foundation
    2001 - 2006
     

Professional activities & recognition

Selected international presentations

  • 2019: AFib-TrainNet -“Human atrial cellular electrophysiology and dynamic-clamp technique” (Copenhagen, Denmark)
  • 2017: “Connecting human heart cells with mathematical models of ion currents in-vitro” (Leeds, UK)
  • 2016: AFib-TrainNet -“Dynamic-clamping human atrial cells: contribution of ISK to action potential changes in AF” (Copenhagen, Denmark)
  • 2014: “Connecting human heart cells with mathematical models of ion currents in-vitro” (Manchester, UK)
  • 2013: Exercise in Medicine -“Basic mechanisms of atrial fibrillation: insights from human atrial cells and failing rabbit hearts” (Trondheim, Norway)
  • 2013: Functional Imaging and Modeling of the Heart -“Atrial fibrillation: ionic mechanisms of self-perpetuation and pharmacological prevention” (London, UK)
  • 2012: Heart Rhythm UK - "Atrial cellular remodelling by heart disease, arrhythmias and drugs" (Birmingham, UK)
  • 2012: Physiological Society - "Mechanisms of human atrial fibrillation: insights from cellular electrophysiology studies" (Manchester, UK)
  • 2010: American College of Cardiology - "Remodelling of the action potential in atrial fibrillation" (Atlanta, GA, USA)
  • 2010: California Heart Rhythm Symposium - "Cellular basis of atrial fibrillation" (Santa Monica, CA, USA)
  • 2009: Recent Developments in Interventional Cardiology, associated with Br J Hosp Med - "Causes and mechanisms of atrial fibrillation and ventricular arrhythmias" (London, UK)
  • 2009: American College of Cardiology - "Electrical Remodeling in Atrial Fibrillation" (Orlando, FL, USA)
  • 2009: British Pharmacological Society & German Societies for Pharmacology and Clinical Pharmacology - "Cardiac adrenergic control and atrial fibrillation" (Dresden, Germany)
  • 2007: California Heart Rhythm Symposium - "Cellular bases for human atrial fibrillation" (Santa Monica, CA, USA)
  • 2005: Europace - "Remodelling the potassium sodium pump during atrial fibrillation" (Prague, Czech Republic)
  • 2003: Vascular Biology Working Group - "Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: Evidence of pharmacological remodeling" (Vienna, Austria)