2025

Woraharn, W. et al. (2025) Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer. Journal of Pathology: Clinical Research, 11(3), e70031. (doi: 10.1002/2056-4538.70031)

Dolan, R. D. et al. (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3(1), 7. (doi: 10.1038/s44276-024-00119-w) (PMID:39910331)

2024

Pennel, K. et al. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14(12), 1629. (doi: 10.3390/biom14121629)

Galbraith, N. J. et al. (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48, 102064. (doi: 10.1016/j.tranon.2024.102064) (PMID:39068768)

Knight, Katrina, Bigley, Christopher, Pennel, Kathryn, Hay, Jennifer, Maka, Noori, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Park, James ORCID: https://orcid.org/0000-0002-6551-2037, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10, e12385. (doi: 10.1002/2056-4538.12385) (PMID:38853386)

McKenzie, Molly, Lian, Guang-Yu, Pennel, Kathryn A.F., Quinn, Jean A. ORCID: https://orcid.org/0000-0002-8267-0993, Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10(12), e32904. (doi: 10.1016/j.heliyon.2024.e32904) (PMID:38975078) (PMCID:PMC11226910)

Hatthakarnkul, P. et al. (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10(3), e12374. (doi: 10.1002/2056-4538.12374) (PMID:38650367) (PMCID:PMC11035902)

Pennel, Kathryn, Dutton, Louise ORCID: https://orcid.org/0000-0002-9336-7826, Melissourgou-Syka, Lydia ORCID: https://orcid.org/0000-0002-0926-2328, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695, Birch, Joanna ORCID: https://orcid.org/0000-0001-9522-8435 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, e14. (doi: 10.1017/erm.2024.15) (PMID:38623751) (PMCID:PMC11140547)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

2023

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133(23), e168277. (doi: 10.1172/JCI168277) (PMID:37824211) (PMCID:PMC10688992)

Greenland, Kyle K., Pennel, Kathryn, Cioccoloni, Giorgia, Rogerson, Connor, Barnieh, Francis M. and Speirs, Valerie (2023) Trailblazers in cancer research: the next generation – the British Association of Cancer Research early-career conference. Biology Open, 12(10), bio060121. (doi: 10.1242/bio.060121) (PMID:37846765) (PMCID:PMC10602000)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)

Hatthakarnkul, P. et al. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14(10), pp. 1837-1847. (doi: 10.7150/jca.83910) (PMID:37476187) (PMCID:PMC10355195)

Pennel, Kathryn, Morrow, Elizabeth, Hatthakarnkul, Phimmada, Leslie, Holly ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Andersen, Ditte, Jamieson, Nigel ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12(12), pp. 13225-13240. (doi: 10.1002/cam4.6014) (PMID:37199043) (PMCID:PMC10315752)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Alexander, P.G., van Wyk, H.C. ORCID: https://orcid.org/0000-0002-4978-5000, Pennel, K.A.F., Hay, J., McMillan, D.C. ORCID: https://orcid.org/0000-0003-4260-5334, Horgan, P.G. ORCID: https://orcid.org/0000-0001-5557-7905, Roxburgh, C.S.D. ORCID: https://orcid.org/0000-0002-2649-6695, Edwards, J. ORCID: https://orcid.org/0000-0002-7192-6906 and Park, J.H. ORCID: https://orcid.org/0000-0002-6551-2037 (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

2022

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

2021

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

2020

Alexander, P.G. et al. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

2019

Pennel, Kathryn A.F., Park, James H. ORCID: https://orcid.org/0000-0002-6551-2037, McMillan, Donald C. ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia K. ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)

Articles

Woraharn, W. et al. (2025) Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer. Journal of Pathology: Clinical Research, 11(3), e70031. (doi: 10.1002/2056-4538.70031)

Dolan, R. D. et al. (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3(1), 7. (doi: 10.1038/s44276-024-00119-w) (PMID:39910331)

Pennel, K. et al. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14(12), 1629. (doi: 10.3390/biom14121629)

Galbraith, N. J. et al. (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48, 102064. (doi: 10.1016/j.tranon.2024.102064) (PMID:39068768)

Knight, Katrina, Bigley, Christopher, Pennel, Kathryn, Hay, Jennifer, Maka, Noori, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Park, James ORCID: https://orcid.org/0000-0002-6551-2037, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10, e12385. (doi: 10.1002/2056-4538.12385) (PMID:38853386)

McKenzie, Molly, Lian, Guang-Yu, Pennel, Kathryn A.F., Quinn, Jean A. ORCID: https://orcid.org/0000-0002-8267-0993, Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10(12), e32904. (doi: 10.1016/j.heliyon.2024.e32904) (PMID:38975078) (PMCID:PMC11226910)

Hatthakarnkul, P. et al. (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10(3), e12374. (doi: 10.1002/2056-4538.12374) (PMID:38650367) (PMCID:PMC11035902)

Pennel, Kathryn, Dutton, Louise ORCID: https://orcid.org/0000-0002-9336-7826, Melissourgou-Syka, Lydia ORCID: https://orcid.org/0000-0002-0926-2328, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695, Birch, Joanna ORCID: https://orcid.org/0000-0001-9522-8435 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, e14. (doi: 10.1017/erm.2024.15) (PMID:38623751) (PMCID:PMC11140547)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133(23), e168277. (doi: 10.1172/JCI168277) (PMID:37824211) (PMCID:PMC10688992)

Greenland, Kyle K., Pennel, Kathryn, Cioccoloni, Giorgia, Rogerson, Connor, Barnieh, Francis M. and Speirs, Valerie (2023) Trailblazers in cancer research: the next generation – the British Association of Cancer Research early-career conference. Biology Open, 12(10), bio060121. (doi: 10.1242/bio.060121) (PMID:37846765) (PMCID:PMC10602000)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)

Hatthakarnkul, P. et al. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14(10), pp. 1837-1847. (doi: 10.7150/jca.83910) (PMID:37476187) (PMCID:PMC10355195)

Pennel, Kathryn, Morrow, Elizabeth, Hatthakarnkul, Phimmada, Leslie, Holly ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Andersen, Ditte, Jamieson, Nigel ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12(12), pp. 13225-13240. (doi: 10.1002/cam4.6014) (PMID:37199043) (PMCID:PMC10315752)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Alexander, P.G., van Wyk, H.C. ORCID: https://orcid.org/0000-0002-4978-5000, Pennel, K.A.F., Hay, J., McMillan, D.C. ORCID: https://orcid.org/0000-0003-4260-5334, Horgan, P.G. ORCID: https://orcid.org/0000-0001-5557-7905, Roxburgh, C.S.D. ORCID: https://orcid.org/0000-0002-2649-6695, Edwards, J. ORCID: https://orcid.org/0000-0002-7192-6906 and Park, J.H. ORCID: https://orcid.org/0000-0002-6551-2037 (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Alexander, P.G. et al. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

Pennel, Kathryn A.F., Park, James H. ORCID: https://orcid.org/0000-0002-6551-2037, McMillan, Donald C. ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia K. ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)