Dr Colin Steele

  • Clinical Senior Lecturer/ Honorary Consultant in Surgery (Clinical Research Garscube)

email: Colin.Steele@glasgow.ac.uk
pronouns: He/him/his

RI Cancer Sciences, Beatson Institute, Garscube Campus, Switchback Road, Bearsden, G61 1BD

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-8518-1223

Research interests

Research groups

  • Cancer Evolution in Time & Space
  • Immunology & Cancer

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2016 | 2015
Number of items: 22.

2024

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Fetit, R. et al. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4(2), pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319) (PMID:38358352) (PMCID:PMC10903300)

2023

Galbraith, N. J. et al. (2023) Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study. International Journal of Surgery, 109(11), pp. 3375-3382. (doi: 10.1097/JS9.0000000000000617) (PMID:37678294) (PMCID:PMC10651229)

McMahon, R. K., O'Cathail, S. M. , Nair, H., Steele, C. W. , Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G. and Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25(9), pp. 1783-1794. (doi: 10.1111/codi.16667) (PMID:37485654)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

2022

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Gould, L. E., Pring, E. T., Drami, I., Moorghen, M., Naghibi, M., Jenkins, J. T., Steele, C. W. and Roxburgh, C. S.D. (2022) A systematic review of the pathological determinants of outcome following resection by pelvic exenteration of locally advanced and locally recurrent rectal cancer. International Journal of Surgery, 104, 106738. (doi: 10.1016/j.ijsu.2022.106738) (PMID:35781038)

2021

Galbraith, N. J. , Wood, C. and Steele, C. W. (2021) Targeting metastatic colorectal cancer with immune oncological therapies. Cancers, 13(14), 3566. (doi: 10.3390/cancers13143566) (PMID:34298779) (PMCID:PMC8307556)

McSorley, S. T. , Steele, C. W. , Anderson, J. H. and McKinlay, S. (2021) Comment on 'Preoperative intravenous iron therapy and survival after colorectal cancer surgery: long term results from the IVICA randomised controlled trial'. Colorectal Disease, 23(2), pp. 555-556. (doi: 10.1111/codi.15428) (PMID:33159348)

2020

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2020) Authors' reply: Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections. BJS Open, 4(4), pp. 730-731. (doi: 10.1002/bjs5.50286) (PMID:32297454) (PMCID:PMC7397349)

McSorley, S. T. , Anderson, J. H., Whittle, T., Roxburgh, C. S. , Horgan, P. G. , McMillan, D. C. and Steele, C. W. (2020) The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer. Perioperative Medicine, 9, 17. (doi: 10.1186/s13741-020-00146-4) (PMID:32537137) (PMCID:PMC7288411)

McSorley, S. T. , Tham, A., Dolan, R. D. , Steele, C. W. , Ramsingh, J., Roxburgh, C. , Horgan, P. G. and McMillan, D. C. (2020) Perioperative blood transfusion is associated with the postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Annals of Surgical Oncology, 27, pp. 833-843. (doi: 10.1245/s10434-019-07984-7) (PMID:31664621) (PMCID:PMC7000540)

2019

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2019) Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections. BJS Open, 3(6), pp. 830-839. (doi: 10.1002/bjs5.50224) (PMID:31832590) (PMCID:PMC6887908)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)

Reader, C. S. et al. (2019) The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology, 249(3), pp. 332-342. (doi: 10.1002/path.5320) (PMID:31259422) (PMCID:PMC6852434)

McSorley, S. T. , Tham, A., Steele, C. W. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2019) Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. European Journal of Surgical Oncology, 45(7), pp. 1205-1211. (doi: 10.1016/j.ejso.2019.02.027) (PMID:30850153)

McSorley, S. , Johnstone, M., Steele, C. W. , Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. C. and Mansouri, D. (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. International Journal of Colorectal Disease, 34(3), pp. 401-408. (doi: 10.1007/s00384-018-3211-7) (PMID:30515556)

2018

McSorley, S.T. , Steele, C.W. and McMahon, A.J. (2018) Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery. BJS Open, 2(4), pp. 185-194. (doi: 10.1002/bjs5.68) (PMID:30079387) (PMCID:PMC6069350)

2016

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)

2015

Palani Velu, L. K., Steele, C. W. , Dickson, E., Carter, C. R., McKay, C. J., Horgan, P. G. , McMillan, D. C. and Jamieson, N. B. (2015) RE:nab-paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial. Journal of the National Cancer Institute, 107(9), djv204. (doi: 10.1093/jnci/djv204) (PMID:26251329)

Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi: 10.1002/path.4555) (PMID:25950520)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

This list was generated on Sat May 18 15:20:17 2024 BST.
Jump to: Articles
Number of items: 22.

Articles

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Fetit, R. et al. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4(2), pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319) (PMID:38358352) (PMCID:PMC10903300)

Galbraith, N. J. et al. (2023) Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study. International Journal of Surgery, 109(11), pp. 3375-3382. (doi: 10.1097/JS9.0000000000000617) (PMID:37678294) (PMCID:PMC10651229)

McMahon, R. K., O'Cathail, S. M. , Nair, H., Steele, C. W. , Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G. and Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25(9), pp. 1783-1794. (doi: 10.1111/codi.16667) (PMID:37485654)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Gould, L. E., Pring, E. T., Drami, I., Moorghen, M., Naghibi, M., Jenkins, J. T., Steele, C. W. and Roxburgh, C. S.D. (2022) A systematic review of the pathological determinants of outcome following resection by pelvic exenteration of locally advanced and locally recurrent rectal cancer. International Journal of Surgery, 104, 106738. (doi: 10.1016/j.ijsu.2022.106738) (PMID:35781038)

Galbraith, N. J. , Wood, C. and Steele, C. W. (2021) Targeting metastatic colorectal cancer with immune oncological therapies. Cancers, 13(14), 3566. (doi: 10.3390/cancers13143566) (PMID:34298779) (PMCID:PMC8307556)

McSorley, S. T. , Steele, C. W. , Anderson, J. H. and McKinlay, S. (2021) Comment on 'Preoperative intravenous iron therapy and survival after colorectal cancer surgery: long term results from the IVICA randomised controlled trial'. Colorectal Disease, 23(2), pp. 555-556. (doi: 10.1111/codi.15428) (PMID:33159348)

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2020) Authors' reply: Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections. BJS Open, 4(4), pp. 730-731. (doi: 10.1002/bjs5.50286) (PMID:32297454) (PMCID:PMC7397349)

McSorley, S. T. , Anderson, J. H., Whittle, T., Roxburgh, C. S. , Horgan, P. G. , McMillan, D. C. and Steele, C. W. (2020) The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer. Perioperative Medicine, 9, 17. (doi: 10.1186/s13741-020-00146-4) (PMID:32537137) (PMCID:PMC7288411)

McSorley, S. T. , Tham, A., Dolan, R. D. , Steele, C. W. , Ramsingh, J., Roxburgh, C. , Horgan, P. G. and McMillan, D. C. (2020) Perioperative blood transfusion is associated with the postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Annals of Surgical Oncology, 27, pp. 833-843. (doi: 10.1245/s10434-019-07984-7) (PMID:31664621) (PMCID:PMC7000540)

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2019) Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections. BJS Open, 3(6), pp. 830-839. (doi: 10.1002/bjs5.50224) (PMID:31832590) (PMCID:PMC6887908)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)

Reader, C. S. et al. (2019) The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology, 249(3), pp. 332-342. (doi: 10.1002/path.5320) (PMID:31259422) (PMCID:PMC6852434)

McSorley, S. T. , Tham, A., Steele, C. W. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2019) Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. European Journal of Surgical Oncology, 45(7), pp. 1205-1211. (doi: 10.1016/j.ejso.2019.02.027) (PMID:30850153)

McSorley, S. , Johnstone, M., Steele, C. W. , Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. C. and Mansouri, D. (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. International Journal of Colorectal Disease, 34(3), pp. 401-408. (doi: 10.1007/s00384-018-3211-7) (PMID:30515556)

McSorley, S.T. , Steele, C.W. and McMahon, A.J. (2018) Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery. BJS Open, 2(4), pp. 185-194. (doi: 10.1002/bjs5.68) (PMID:30079387) (PMCID:PMC6069350)

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)

Palani Velu, L. K., Steele, C. W. , Dickson, E., Carter, C. R., McKay, C. J., Horgan, P. G. , McMillan, D. C. and Jamieson, N. B. (2015) RE:nab-paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial. Journal of the National Cancer Institute, 107(9), djv204. (doi: 10.1093/jnci/djv204) (PMID:26251329)

Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi: 10.1002/path.4555) (PMID:25950520)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

This list was generated on Sat May 18 15:20:17 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • IL6/JAK/STAT3 pathway in colorectal cancer
    Office of the Chief Scientific Adviser
    2023 - 2025
     
  • Investigating the role of dietary constitution in radiotherapy responses in rectal cancer
    Cancer Research UK
    2023 - 2023
     
  • Defining pro-tumourigenic neutrophil phenotypes and tumour-neutrophil interactions to identify targets for therapy in metastatic colorectal cancer
    UK Research and Innovation
    2022 - 2026
     
  • Identification of novel tumour markers to aid prediction of high risk rectal cancers for local recurrence
    NHS Greater Glasgow and Clyde Endowment Funds
    2022 - 2023
     
  • Combining Radiation with JAK inhibitors as a novel therapeutic strategy
    Cancer Research UK
    2022 - 2022
     
  • Secondary prevention of colorectal liver metastasis via manipultion of the gut-liver axis
    Tenovus Scotland
    2021 - 2022
     
  • Are CXCR2 positive cells important in generating an immunosuppressive metastatic niche for colorectal metastatic disease in the liver?
    Cancer Research UK
    2018 - 2020
     
  • Characterising CXCR2 expressing neutrophils in colorectal liver metastases.
    Academy of Medical Sciences
    2018 - 2020
     
  • Characterising the role of CXCR2 signalling in colorectal cancer metastasis
    Chief Scientist Office
    2017 - 2020