Number of items: 74.
2024
Laing, A. et al.
(2024)
Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism.
British Journal of Haematology,
(doi: 10.1111/bjh.19884)
(Early Online Publication)
Mardilovich, K., Naylor, G., Julian, L., Phinichkusolchit, N., Keeshan, K. , Blyth, K. and Olson, M. F.
(2024)
Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice.
Disease Models and Mechanisms, 17(5),
dmm050631.
(doi: 10.1242/dmm.050631)
(PMID:38616733)
(PMCID:PMC11139034)
2023
Stavrou, V. et al.
(2023)
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.
Cancer Immunology, Immunotherapy, 72(3),
pp. 543-560.
(doi: 10.1007/s00262-022-03268-4)
(PMID:35962843)
(PMCID:PMC9947083)
2022
Jamieson, S. A., Pudjihartono, M., Horne, C. R., Viloria, J. S., Dunlop, J. L., McMillan, H. D., Day, R. C., Keeshan, K. , Murphy, J. M. and Mace, P. D.
(2022)
Nanobodies identity an activated state of the TRIB2 pseudokinase.
Structure, 30(11),
1518-1529.e5.
(doi: 10.1016/j.str.2022.08.006)
(PMID:36108635)
Pirillo, C. et al.
(2022)
Metalloproteinase inhibition reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness.
Blood Advances, 6(10),
pp. 3126-3141.
(doi: 10.1182/bloodadvances.2021004321)
(PMID:35157757)
(PMCID:PMC9131921)
Lal, R., Ritchie, J., Richmond, L. and Keeshan, K.
(2022)
Detecting endogenous TRIB2 protein expression by flow cytometry and western blotting.
In:
Pseudokinases.
Series: Methods in enzymology (667).
Academic Press, pp. 59-77.
ISBN 9780323915427
(doi: 10.1016/bs.mie.2022.03.024)
2021
Aung, M. M. K., Mills, M. L., Bittencourt-Silvestre, J. and Keeshan, K.
(2021)
Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia.
Molecular Oncology, 15(9),
pp. 2253-2272.
(doi: 10.1002/1878-0261.12899)
(PMID:33421304)
(PMCID:PMC8410545)
Latif, A.-L. et al.
(2021)
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature Communications, 12,
241.
(doi: 10.1038/s41467-020-20378-8)
(PMID:33431824)
(PMCID:PMC7801601)
Keeshan, K.
(2021)
Superenhancing AML with Trib1.
Blood, 137(1),
pp. 8-9.
(doi: 10.1182/blood.2020008315)
(PMID:33410899)
Marensi, V., Keeshan, K. R. and MacEwan, D. J.
(2021)
Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors.
Biochemical Pharmacology, 183,
114348.
(doi: 10.1016/j.bcp.2020.114348)
(PMID:33242449)
McMillan, H. D., Keeshan, K. , Dunbier, A. K. and Mace, P. D.
(2021)
Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond.
Cancers, 13(12),
3060.
(doi: 10.3390/cancers13123060)
(PMID:34205360)
(PMCID:PMC8235551)
2020
Richmond, L. and Keeshan, K.
(2020)
Pseudokinases: a tribble‐edged sword.
FEBS Journal, 287(19),
pp. 4170-4182.
(doi: 10.1111/febs.15096)
(PMID:31621188)
Mitxitorena, I., Somma, D. , Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E. L., Kiely, P. A., Walden, H. , Keeshan, K. and Carmody, R. J.
(2020)
The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.
Journal of Biological Chemistry, 295(33),
pp. 11754-11763.
(doi: 10.1074/jbc.RA120.014113)
(PMID:32587091)
(PMCID:PMC7450122)
Sarrou, E. , Richmond, L., Carmody, R. J. , Gibson, B. and Keeshan, K.
(2020)
CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis.
International Journal of Molecular Sciences, 21(12),
4266.
(doi: 10.3390/ijms21124266)
(PMID:32549410)
(PMCID:PMC7352880)
2019
Collins, P. E., Somma, D. , Kerrigan, D., Herrington, F., Keeshan, K. R. , Nibbs, R. J.B. and Carmody, R. J.
(2019)
The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.
Proceedings of the National Academy of Sciences of the United States of America, 116(51),
pp. 25828-25838.
(doi: 10.1073/pnas.1900408116)
(PMID:31772019)
(PMCID:PMC6926074)
Smith, E. L., Somma, D. , Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J.
(2019)
The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80.
Nucleic Acids Research, 47(21),
pp. 11151-11161.
(doi: 10.1093/nar/gkz873)
(PMID:31598684)
(PMCID:PMC6868378)
Mussai, F. et al.
(2019)
Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.
International Journal of Cancer, 145(8),
pp. 2201-2208.
(doi: 10.1002/ijc.32028)
(PMID:30485425)
(PMCID:PMC6767531)
2018
Chaudhury, S. et al.
(2018)
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature Communications, 9,
5280.
(doi: 10.1038/s41467-018-07584-1)
(PMID:30538250)
(PMCID:PMC6290074)
Salomé, M. , Hopcroft, L. and Keeshan, K.
(2018)
Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis.
Experimental Hematology, 66,
63-78.e13.
(doi: 10.1016/j.exphem.2018.07.005)
(PMID:30031847)
Foulkes, D. M. et al.
(2018)
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.
Science Signaling, 11(549),
eaat7951.
(doi: 10.1126/scisignal.aat7951)
(PMID:30254057)
(PMCID:PMC6553640)
Newcombe, A. A., Gibson, B. E.S. and Keeshan, K.
(2018)
Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia.
Experimental Hematology, 63,
pp. 1-11.
(doi: 10.1016/j.exphem.2018.03.008)
(PMID:29608923)
Salomé, M. , Magee, A., Yalla, K., Chaudhury, S. , Sarrou, E. , Carmody, R. J. and Keeshan, K.
(2018)
A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling.
Cell Death and Disease, 9(5),
443.
(doi: 10.1038/s41419-018-0467-3)
(PMID:29670085)
(PMCID:PMC5906628)
O'Connor, C., Yalla, K., Salome, M. , Moka, H. A., Gómez Castañeda, E., Eyers, P. A. and Keeshan, K.
(2018)
Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant
acute myeloid leukaemia linked to elevated Bcl2.
Oncotarget, 9(19),
pp. 14977-14992.
(doi: 10.18632/oncotarget.24525)
(PMID:29599919)
(PMCID:PMC5871090)
2017
Laing, A. A., Harrison, C. J., Gibson, B. E.S. and Keeshan, K.
(2017)
Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia.
Experimental Hematology, 54,
pp. 40-50.
(doi: 10.1016/j.exphem.2017.06.007)
(PMID:28668350)
Sarrou, E. , Gibson, B. and Keeshan, K.
(2017)
Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation.
46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017.
S69.
(doi: 10.1016/j.exphem.2017.06.134)
Carmody, R. and Keeshan, K.
(2017)
The Tribble with APL: a new road to therapy.
Cancer Cell, 31(5),
pp. 612-613.
(doi: 10.1016/j.ccell.2017.04.011)
(PMID:28486101)
Eyers, P. A., Keeshan, K. and Kannan, N.
(2017)
Tribbles in the 21st Century: the evolving roles of Tribbles pseudokinases in biology and disease.
Trends in Cell Biology, 27(4),
pp. 284-298.
(doi: 10.1016/j.tcb.2016.11.002)
(PMID:27908682)
(PMCID:PMC5382568)
Ahmed, A., Wan, X., Mitxitorena, I., Lindsay, A. J., Pandolfi, P. P., McCaffrey, M. W., Keeshan, K. , Chen, Y. H. and Carmody, R. J.
(2017)
Regulation of NF-κB by PML and PML-RARα.
Scientific Reports, 7,
44539.
(doi: 10.1038/srep44539)
(PMID:28317833)
(PMCID:PMC5357907)
2016
Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K.
(2016)
The Bone Marrow Niche Distinguishes Young and Old Leukemia.
58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
O'Connor, C. et al.
(2016)
The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia.
Oncogene, 35(40),
pp. 5272-5281.
(doi: 10.1038/onc.2016.66)
(PMID:26996668)
Keeshan, K. , Vieugué, P., Chaudhury, S. , Rishi, L., Gaillard, C., LIang, L., Garcia, E., Nakumura, T., Omidvar, N. and Kogan, S. C.
(2016)
Co-operative leukaemogenesis in acute myeloid leukaemia and acute promyelocytic
leukaemia reveal C/EBPα as a common target of TRIB1 and PML/RARA.
Haematologica, 101(10),
pp. 1228-1236.
(doi: 10.3324/haematol.2015.138503)
(PMID:27390356)
(PMCID:PMC5046652)
Liang, K. L., Paredes, R., Carmody, R. , Eyers, P. A., Meyer, S., McCarthy, T. V. and Keeshan, K.
(2016)
Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C.
International Journal of Molecular Sciences, 17(9),
1378.
(doi: 10.3390/ijms17091378)
(PMID:27563873)
(PMCID:PMC5037658)
Chaudhury, S. , Gibson, B. and Keeshan, K.
(2016)
The Impact of Cellular Age on Leukaemic Transformation.
21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.
p. 12.
Salomè, M. and Keeshan, K.
(2016)
TRIB2 Regulates the Cell Cycle Under Stress Conditions in a Murine Cell Model of Leukaemia.
21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.
Sarrou, S., Gibson, B. and Keeshan, K.
(2016)
Efficient Genome Editing of Mouse Hematopoietic Cells Using Crispr/Cas9 Technology.
21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2013.
p. 295.
Yalla, K., O'Connor, C., Campos, J. and Keeshan, K.
(2016)
TRIB2 Transformed GMP is the Myeloid Leukaemia Initiating Cell.
21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.
Liang, K. L., O'Connor, C., Veiga, J. P., McCarthy, T. V. and Keeshan, K.
(2016)
TRIB2 regulates normal and stress-induced thymocyte proliferation.
Cell Discovery, 2,
15050.
(doi: 10.1038/celldisc.2015.50)
(PMID:27462446)
(PMCID:PMC4860960)
2015
Latif, A.-L., Cole, J. J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. D.
(2015)
Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia.
Blood, 126(23),
p. 674.
(doi: 10.1182/blood.V126.23.674.674)
Salome, M. , Campos, J. and Keeshan, K.
(2015)
TRIB2 and the ubiquitin proteasome system in cancer.
Biochemical Society Transactions, 43(5),
pp. 1089-1094.
(doi: 10.1042/bst20150103)
(PMID:26517929)
Chaudhury, S. S. , Morison, J. K., Gibson, B. E.S. and Keeshan, K.
(2015)
Insights into cell ontogeny, age and acute myeloid leukaemia.
Experimental Hematology, 43(9),
pp. 745-755.
(doi: 10.1016/j.exphem.2015.05.008)
(PMID:26051919)
Liang, K. L., O'Connor, C., McCarthy, T. V. and Keeshan, K.
(2015)
Investigation of the role of TRIB2 in normal murine hematopoiesis.
Experimental Hematology, 43(9),
S77.
(doi: 10.1016/j.exphem.2015.06.181)
Pellicano, F., O'Connor, C. and Keeshan, K.
(2015)
An investigation of the leukaemia initiating cell in TRIB2 mediated AML.
Experimental Hematology, 43(9),
S88.
(doi: 10.1016/j.exphem.2015.06.228)
O'Connor, C., Campos, J., Osinski, J. M., Gronostajski, R. M., Michie, A. and Keeshan, K.
(2015)
Nfix expression critically modulates early B lymphopoiesis and myelopoiesis.
PLoS ONE, 10(3),
e0120102.
(doi: 10.1371/journal.pone.0120102)
(PMID:25780920)
(PMCID:PMC4363787)
2014
Lohan, F., O'Connor, C., Campos, J., Ohlsson, E., Salome, M. , Forde, C., Cahill, M., Kiely, P., Porse, B. and Keeshan, K.
(2014)
Targeting C/EBPalpha p42 and oncogene cooperativity in acute myeloid leukaemia.
Experimental Hematology, 42(8),
S42.
(doi: 10.1016/j.exphem.2014.07.153)
O'Connor, C., Campos, J., Murphy, B., Hannon, M., Gronostajski, R., Michie, A. and Keeshan, K.
(2014)
NFIX influences stem and progenitor lineage fate.
Experimental Hematology, 42(8),
S54.
(doi: 10.1016/j.exphem.2014.07.205)
Ni Ealaithe, C., Rishi, L. and Keeshan, K.
(2014)
Analysis of Trib genes in leukaemia.
Irish Journal of Medical Science, 183(S4),
S133-S134.
(doi: 10.1007/s11845-014-1153-9)
Rishi, L. et al.
(2014)
Regulation of Trib2 by an E2F1-C/EBP feedback loop in AML cell proliferation.
Blood, 123(15),
pp. 2389-2400.
(doi: 10.1182/blood-2013-07-511683)
(PMID:24516045)
Walsh, S., Gavin, A., Wyatt, S., O'Connor, C., Keeshan, K. , Nolan, Y. M., O'Keeffe, G. W. and Sullivan, A. M.
(2014)
Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease.
International Journal of Neuroscience, 125(1),
pp. 70-77.
(doi: 10.3109/00207454.2014.904304)
2013
Lohan, F. et al.
(2013)
Elucidation and therapeutic targeting of the molecular mechanism of TRIB2-mediated acute myeloid leukaemia.
Blood, 122(21),
p. 3792.
Ryan, S.M., O’Keeffe, G.W., O'Connor, C., Keeshan, K. and Nolan, Y.M.
(2013)
Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.
Brain, Behavior, and Immunity, 33,
pp. 7-13.
(doi: 10.1016/j.bbi.2013.03.005)
Keeshan, K. , Hannon, M., Rishi, L., Hasemann, M., Frank, A.-K., Timoney, J., O'Connor, C., Cahill, M. and Porse, B.
(2013)
E2F1 positively regulates Trib2 pseudokinase expression and proliferation in acute leukaemia.
Experimental Hematology, 41(8),
S50.
(doi: 10.1016/j.exphem.2013.05.197)
Keeshan, K. , O'Connor, C., Campos, J., Murphy, B., Hannon, M. and Michie, A.
(2013)
NFIX expression critically modulates early B lymphopoiesis and myelopoiesis.
Experimental Hematology, 41(8),
S68.
(doi: 10.1016/j.exphem.2013.05.267)
Liang, K.L., Rishi, L. and Keeshan, K.
(2013)
Tribbles in acute leukemia.
Blood, 121(21),
pp. 4265-4270.
(doi: 10.1182/blood-2012-12-471300)
Lohan, F. and Keeshan, K.
(2013)
The functionally diverse roles of tribbles.
Biochemical Society Transactions, 41(4),
pp. 1096-1100.
(doi: 10.1042/BST20130105)
2012
Hannon, M., Lohan, F., Erbilgin, Y., Sayitoglu, M., O’Hagan, K., Mills, K., Ozbek, U. and Keeshan, K.
(2012)
Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL.
British Journal of Haematology, 158(5),
pp. 626-634.
(doi: 10.1111/j.1365-2141.2012.09222.x)
Lohan, F. M. and Keeshan, K.
(2012)
Mechanism of Trib2 mediated degradation of C/EBP-ain acute myelogenous leukaemia.
British Journal of Haematology, 157(S1),
p. 57.
(doi: 10.1111/j.1365-2141.2012.09071.x)
Keeshan, K.
(2012)
Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL.
In: British Society for Haematology 52nd Annual Scientific Meeting, Glasgow, 16-18 April 2012,
2011
Hannon, M., Al-Shahrour, F., Ebert, B. L. and Keeshan, K.
(2011)
Regulation of Trib2 gene expression in normal and AML cells.
British Journal of Haematology, 153(Supl 1),
pp. 6-7.
(doi: 10.1111/j.1365-2141.2011.08609.x)
The Trustees of the University Of Pennsylvania
(2011)
Diagnostic and Therapeutic Utility of Tribbles-2 in Human Cancers.
.
2010
Keeshan, K.
(2010)
643 Degradation of C/EBPalpha by Trib proteins correlates with Trib mediated acute myeloid leukemia.
European Journal of Cancer Supplements, 8(5),
pp. 162-163.
(doi: 10.1016/S1359-6349(10)71443-9)
Dedhia, P.H., Keeshan, K. , Uljon, S., Xu, L., Vega, M.E., Shestova, O., Zaks-Zilberman, M., Romany, C., Blacklow, S.C. and Pear, W.S.
(2010)
Differential ability of Tribbles family members to promote degradation of C/EBP and induce acute myelogenous leukemia.
Blood, 116(8),
pp. 1321-1328.
(doi: 10.1182/blood-2009-07-229450)
Keeshan, K. , Bailis, W., Dedhia, P. H., Vega, M. E., Shestova, O., Xu, L., Toscano, K., Uljon, S. N., Blacklow, S. C. and Pear, W. S.
(2010)
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood, 116(23),
pp. 4948-4957.
(doi: 10.1182/blood-2009-10-247361)
2008
Keeshan, K. , Shestova, O., Ussin, L. and Pear, W.S.
(2008)
Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia.
Blood Cells, Molecules, and Diseases, 40(1),
pp. 119-121.
(doi: 10.1016/j.bcmd.2007.06.005)
2007
Wouters, B.J. et al.
(2007)
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Blood, 110(10),
pp. 3706-3714.
(doi: 10.1182/blood-2007-02-073486)
2006
Chen, Y.-X., Yan, J., Keeshan, K. , Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S. and Hua, X.
(2006)
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Proceedings of the National Academy of Sciences of the United States of America, 103(4),
pp. 1018-1023.
(doi: 10.1073/pnas.0510347103)
Ferrari-Amorotti, G., Keeshan, K. , Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J. and Calabretta, B.
(2006)
Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBP.
Blood, 108(4),
pp. 1353-1362.
(doi: 10.1182/blood-2006-01-011833)
Keeshan, K. et al.
(2006)
Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia.
Cancer Cell, 10(5),
pp. 401-411.
(doi: 10.1016/j.ccr.2006.09.012)
Keeshan, K. et al.
(2006)
Tribbles homolog 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia.
Blood, 108(11),
p. 776.
Maillard, I., Tu, L., Sambandam, A., Yashiro-Ohtani, Y., Millholland, J., Keeshan, K. , Shestova, O., Xu, L., Bhandoola, A. and Pear, W. S.
(2006)
The requirement for Notch signaling at the -selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.
Journal of Experimental Medicine, 203(10),
pp. 2239-2245.
(doi: 10.1084/jem.20061020)
2003
Keeshan, K.
(2003)
Transcription activation function of C/EBP is required for induction of granulocytic differentiation.
Blood, 102(4),
pp. 1267-1275.
(doi: 10.1182/blood-2003-02-0477)
Keeshan, K. , Cotter, T.G. and McKenna, S.L.
(2003)
Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1by a phosphoinositide-3-kinase (PI3K)-independent pathway.
British Journal of Haematology, 123(1),
pp. 34-44.
(doi: 10.1046/j.1365-2141.2003.04538.x)
2002
Keeshan, K. , Cotter, T.G. and McKenna, S.L.
(2002)
High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion.
Leukemia, 16(9),
pp. 1725-34.
2001
Keeshan, K. , Mills, K.I., Cotter, T.G. and McKenna, S.L.
(2001)
Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype.
Leukemia, 15(12),
pp. 1823-1833.
2000
Di Bacco, A., Keeshan, K. , McKenna, S. L. and Cotter, T. G.
(2000)
Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis.
Oncologist, 5(5),
pp. 405-415.
(doi: 10.1634/theoncologist.5-5-405)
(PMID:11040277)
This list was generated on Mon Dec 9 07:51:16 2024 GMT.