Professor Chris Halsey

  • Head of School/ Professor of Paediatric Haemato-Oncology (Clinical Research Garscube)

telephone: 01413304811
email: Chris.Halsey@glasgow.ac.uk

Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Garscube Estate, Bearsden, G61 1QH

ORCID iDhttps://orcid.org/0000-0001-5449-5246

Research interests

Group site: Childhood Leukaemia Research Group (Halsey Lab)

Dr Christina Halsey is a Senior Clinical Lecturer and an Honorary NHS Consultant Paediatric Haematologist. She carries out her NHS clinical duties at the Royal Hospital for Sick Children, Glasgow, where she cares for children with a wide range of malignant and non-malignant blood disorders. Her research laboratory is based in the Institute of Cancer Sciences where she investigates mechanisms of central nervous system disease in childhood acute lymphoblastic leukaemia (ALL) and ways to reduce treatment related toxicity in this condition.

Despite great advances in the treatment of paediatric ALL, disease in the central nervous system (CNS) remains challenging.  A better understanding of the mechanisms of CNS engraftment is a necessary pre-requisite for diagnostic and therapeutic advances. Current projects include investigating the adaptation of leukaemic cells to CNS and bone marrow microenvironments and identifying metabolic vulnerabilities that can be exploited therapeutically. A second major interest of the group is in mechanisms and therapeutic strategies that might reduce neurotoxicity associated with treatment for childhood ALL. Dr Halsey is the chief investigator on a study “Biomarkers and discovery of new therapeutic targets for chemotherapy associated neurotoxicity” which is an add-on study for the current UK national leukaemia trial – UKALL 2011.

Dr Halsey collaborates extensively with experienced researchers on a number of projects both in the UK and abroad. Current Collaborators include Prof Josef Vormoor and Dr Julie Irving, Newcastle University, Prof Irene Roberts, Imperial College London, Dr Judy Cannon, University of New Mexico, Prof Shai Izraeli, Sheba Medical Center, Israel and Dr Peter Cole Albert Einstein College of Medicine, New York. 

Dr Halsey is also an active member of several national and international organisations which aim to improve the outlook for children with leukaemia including:

Childhood Leukaemia Research UK (joint organiser)

Childrens Cancer and Leukaemia Group (CCLG) – committee member of the meetings subgroup and Biological Studies Steering Group

International BFM Childhood Leukaemia Study Group – member of Biology & Diagnosis Committee

Ponte di Legno/iBFM – Toxicity working group – chair of methotrexate stroke like syndrome and seizures working parties

 

Publications

List by: Type | Date

Jump to: 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004 | 2003
Number of items: 59.

2022

Cousins, A. et al. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways. Leukemia, 36(12), pp. 2903-2907. (doi: 10.1038/s41375-022-01722-x) (PMID:36289348)

Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K. and Halsey, C. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions. Leukemia, 36(12), pp. 2751-2768. (doi: 10.1038/s41375-022-01714-x) (PMID:36266325)

Pal, D. et al. (2022) hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia. Cell Reports Medicine, 3(8), 100717. (doi: 10.1016/j.xcrm.2022.100717) (PMID:35977468)

2021

Malouf, C., Antunes, E. T.B., O'Dwyer, M., Jakobczyk, H., Sahm, F., Landua, S.-L., Anderson, R. A., Soufi, A., Halsey, C. and Ottersbach, K. (2021) MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia. Blood, 138(21), pp. 2066-2092. (doi: 10.1182/blood.2020006610) (PMID:34111240)

Rice, S. et al. (2021) A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program. Nature Communications, 12, 6905. (doi: 10.1038/s41467-021-27270-z) (PMID:34824279) (PMCID:PMC8616957)

Zanetti, C. et al. (2021) The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13. Blood, 138(19), pp. 1870-1884. (doi: 10.1182/blood.2021011557) (PMID:34424946)

Halsey, C. and Escherich, G. (2021) A “Goldilocks” approach to CNS leukaemia is needed. Blood, 138(4), pp. 288-289. (doi: 10.1182/blood.2021011461) (PMID:34323942)

Andrés-Jensen, L. et al. (2021) Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia. Lancet Haematology, 8(7), e513-e523. (doi: 10.1016/S2352-3026(21)00136-8) (PMID:34171282)

Welisch, G. et al. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? Project Report. OSF. (doi: 10.17605/OSF.IO/KWHQF).

Shi, Y. et al. (2021) Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia. Haematologica, 106(4), pp. 1056-1066. (doi: 10.3324/haematol.2019.241026) (PMID:32139432) (PMCID:PMC8018112)

Lenk, L. et al. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, 73. (doi: 10.1038/s42003-020-01591-z) (PMID:33452446) (PMCID:PMC7810877)

2020

Savino, A. M. et al. (2020) Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on Stearoyl CoA desaturase. Nature Cancer, 1(10), pp. 998-1009. (doi: 10.1038/s43018-020-00115-2) (PMID:33479702) (PMCID:PMC7116605)

Abdelrasoul, H. et al. (2020) Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11, 3194. (doi: 10.1038/s41467-020-16927-w) (PMID:32581241) (PMCID:PMC7314847)

Walker, D. A., Meijer, L., Coyle, B. and Halsey, C. (2020) Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials. Lancet Child and Adolescent Health, 4(3), pp. 242-250. (doi: 10.1016/S2352-4642(19)30333-5) (PMID:31958415)

Forster, V. J., Bell, G. and Halsey, C. (2020) Should nitrous oxide ever be used in oncology patients receiving methotrexate therapy? Pediatric Anesthesia, 30(1), pp. 9-16. (doi: 10.1111/pan.13760) (PMID:31667903)

2019

Yousafzai, Y. M. et al. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, 10623. (doi: 10.1016/j.leukres.2019.106232) (PMID:31706196)

Matheson, E. C. et al. (2019) Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM. Haematologica, 104(9), pp. 1804-1811. (doi: 10.3324/haematol.2017.185975) (PMID:30655370) (PMCID:PMC6717586)

Baquero, P. et al. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33(4), pp. 981-994. (doi: 10.1038/s41375-018-0252-4) (PMID:30185934) (PMCID:PMC6292500)

2018

Alsadeq, A. et al. (2018) IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, 132(15), pp. 1614-1617. (doi: 10.1182/blood-2018-04-844209) (PMID:30154115) (PMCID:PMC6238156)

Halsey, C. (2018) Challenging "privileged" stereotypes - leukemic blasts and the central nervous system. Leukemia Research, 73, pp. 76-77. (doi: 10.1016/j.leukres.2018.08.013) (PMID:30243134)

Wilson, R., Osborne, C. and Halsey, C. (2018) The use of Ommaya reservoirs to deliver central nervous system directed chemotherapy in childhood acute lymphoblastic leukaemia. Pediatric Drugs, 20(4), pp. 293-301. (doi: 10.1007/s40272-018-0298-9) (PMID:29850985)

Forster, V., Escherich, G. and Halsey, C. (2018) Comment on: Successful use of nitrous oxide during lumbar punctures: a call for nitrous oxide in pediatric oncology clinics. Pediatric Blood and Cancer, 65(5), e26930. (doi: 10.1002/pbc.26930) (PMID:29286566)

De Santo, C. et al. (2018) The arginine metabolome in Acute Lymphoblastic Leukemia can be targeted by the PEG-recombinant Arginase I BCT-100. International Journal of Cancer, 142(7), pp. 1490-1502. (doi: 10.1002/ijc.31170) (PMID:29168171) (PMCID:PMC5849425)

Sinclair, P. B. et al. (2018) Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Haematologica, 103(4), pp. 634-644. (doi: 10.3324/haematol.2017.172304) (PMID:29449437) (PMCID:PMC5865429)

Bartram, J., Goulden, N., Wright, G., Adams, S., Brooks, T., Edwards, D., Inglott, S., Yousafzai, Y., Hubank, M. and Halsey, C. (2018) High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments. Haematologica, 103, e113. (doi: 10.3324/haematol.2017.174987) (PMID:29217777)

2017

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2017) Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect. Cancer Chemotherapy and Pharmacology, 79(4), pp. 841-842. (doi: 10.1007/s00280-017-3270-4) (PMID:28289862)

Cousins, A. F., Olivares, O., Michie, A. M. , Gottlieb, E. and Halsey, C. (2017) Association of CNS Involvement in Childhood Acute Lymphoblastic Leukaemia with Cholesterol Biosynthesis Upregulation. Spring Meeting for Clinician Scientists in Training 2017, London, UK, 23 Feb 2017. S35. (doi: 10.1016/S0140-6736(17)30431-2)

Oruganti, S.R., Torres, D.J., Krebsbach, S., Asperti-Boursin, F., Winters, J., Matlawska-Wasowska, K., Winter, S.S., Halsey, C. and Cannon, J.L. (2017) CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia, 31(1), pp. 255-258. (doi: 10.1038/leu.2016.272) (PMID:27698445)

2016

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2016) Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer Chemotherapy and Pharmacology, 78(5), pp. 1093-1096. (doi: 10.1007/s00280-016-3153-0) (PMID:27659182) (PMCID:PMC5083755)

Schmiegelow, K. et al. (2016) Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncology, 17(6), e231-e239. (doi: 10.1016/S1470-2045(16)30035-3)

Williams, M. T.S. et al. (2016) The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukaemia blasts. Blood, 127, 16. (doi: 10.1182/blood-2015-08-665034) (PMID:26869395)

2015

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E. and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi: 10.1016/j.semcdb.2015.09.008) (PMID:26365277)

2014

Irving, J. et al. (2014) Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood, 124(23), pp. 3420-3430. (doi: 10.1182/blood-2014-04-531871) (PMID:25253770) (PMCID:PMC4246039)

Winter, S. and Halsey, C. (2014) Should children presenting with iron deficiency anaemia be screened for coeliac disease? Archives of Disease in Childhood, 99(2), pp. 180-182. (doi: 10.1136/archdischild-2013-305591)

El-Fakhri, N., McDevitt, H., Shaikh, M.G., Halsey, C. and Ahmed, S.F. (2014) Vitamin D and its effects on glucose homeostasis, cardiovascular function and immune function. Hormone Research in Paediatrics, 81(6), pp. 363-378. (doi: 10.1159/000357731)

Halsey, C. (2014) Haematological investigations in paediatrics. In: Goal, K.M. and Carachi, R. (eds.) Hutchison's Atlas of Paediatric Physical Diagnosis. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9789351521525

Halsey, C. (2014) Towards personalised medicine in childhood acute lymphoblastic leukaemia. In: Thomas, A.E. and Halsey, C. (eds.) Controversies in Pediatric and Adolescent Hematology. Kerger, pp. 98-115. ISBN 9783318024234 (doi: 10.1159/000350349)

Thomas, A.E. and Halsey, C. (2014) Controversies in Pediatric and Adolescent Hematology. Series: Pediatric and Adolescent Medicine. Karger. ISBN 9783318024227

Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970) (PMID:24700781)

2013

Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.

Roberts, I. et al. (2013) GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Blood, 122(24), pp. 3908-3917. (doi: 10.1182/blood-2013-07-515148)

2012

Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)

2011

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

Halsey, C. , Buck, G., Richards, S., Vargha-Khadem, F., Hill, F. and Gibson, B. (2011) The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI. Journal of Hematology and Oncology, 4(42), (doi: 10.1186/1756-8722-4-42)

2010

Halsey, C. , Lumley, H. and Luckit, J. (2010) Necrotising external otitis caused by Aspergillus wentii: a case report. Mycoses, 54(4), E211-E213. (doi: 10.1111/J.1439-0507.2009.01815.x)

Halsey, C. , Tunstall, O., Gibson, B., Roberts, I. and Graham, G. (2010) Role of GATA-1s in early hematopoiesis and differences between alternative splicing in human and murine GATA-1. Blood, 115(16), pp. 3415-3416. (doi: 10.1182/blood-2010-02-267930)

2009

Halsey, C. and Chalmers, E.A. (2009) Haematalogical investigations in children. In: Goel, K. and Gupta, D. (eds.) Hutchison's Paediatrics. Jaypee Brothers, Medical Publishers (P) Ltd.. ISBN 9788184485868

2008

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Halsey, C.,. and Chalmers, E.A. (2008) Haematological investigations in paediatrics. In: Goel, K.M. and Gupta, D.K. (eds.) Hutchison's Paediatrics. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9788184485868

Halsey, C. and Roberts, I. (2008) Neonatal Haematology. In: Forfar, J.O. and McIntosh, N. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443103971

2007

Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi: 10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)

2006

Gibson, B. E.S. and Halsey, C. (2006) Nonimmune neonatal anemias. In: Arceci, R., Hann, I. M. and Smith, O. P. (eds.) Pediatric Hematology. Blackwell Publishing: Malden, pp. 130-150. ISBN 9781405134002 (doi: 10.1002/9780470987001.ch7)

2004

Jiskoot, P.M.C., Halsey, C. , Rivers, R., Bain, B.J. and Wilkins, B.S. (2004) Unusual splenic sinusoidal iron overload in sickle cell/haemoglobin D-Punjab disease. Journal of Clinical Pathology, 57(5), pp. 539-540. (doi: 10.1136/jcp.2002.004481) (PMID:15113864) (PMCID:PMC1770290)

2003

Ronghe, M. D., Halsey, C. and Goulden, N. J. (2003) Anticoagulation therapy in children. Pediatric Drugs, 5(12), pp. 803-820. (doi: 10.2165/00148581-200305120-00004) (PMID:14658922)

Amrolia, P. J., Almeida, A., Halsey, C. , Roberts, I. A. G. and Davies, S. C. (2003) Therapeutic challenges in childhood sickle cell disease part 1: current and future treatment options. British Journal of Haematology, 120(5), pp. 725-736. (doi: 10.1046/j.1365-2141.2003.04143.x) (PMID:12614202)

Halsey, C. and Roberts, I. A.G. (2003) The role of hydroxyurea in sickle cell disease. British Journal of Haematology, 120(2), pp. 177-186. (doi: 10.1046/j.1365-2141.2003.03849.x) (PMID:12542474)

Halsey, C. and Roberts, I. (2003) haemopoietic stem cell transplantation for thalassaemia and sickle cell disease. In: Okpala, I.E. (ed.) Comprehensive Care of Sickle Cell Disease. UNSPECIFIED.

Halsey, C. and Roberts, I. (2003) Neonatal Haematology. In: Forfar, J.O., Arneil, G.C., McIntosh, N., Helms, P. and Smyth, R.L. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443071980

This list was generated on Sun May 28 17:43:48 2023 BST.
Jump to: Articles | Book Sections | Edited Books | Research Reports or Papers | Conference or Workshop Item | Conference Proceedings
Number of items: 59.

Articles

Cousins, A. et al. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways. Leukemia, 36(12), pp. 2903-2907. (doi: 10.1038/s41375-022-01722-x) (PMID:36289348)

Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K. and Halsey, C. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions. Leukemia, 36(12), pp. 2751-2768. (doi: 10.1038/s41375-022-01714-x) (PMID:36266325)

Pal, D. et al. (2022) hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia. Cell Reports Medicine, 3(8), 100717. (doi: 10.1016/j.xcrm.2022.100717) (PMID:35977468)

Malouf, C., Antunes, E. T.B., O'Dwyer, M., Jakobczyk, H., Sahm, F., Landua, S.-L., Anderson, R. A., Soufi, A., Halsey, C. and Ottersbach, K. (2021) MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia. Blood, 138(21), pp. 2066-2092. (doi: 10.1182/blood.2020006610) (PMID:34111240)

Rice, S. et al. (2021) A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program. Nature Communications, 12, 6905. (doi: 10.1038/s41467-021-27270-z) (PMID:34824279) (PMCID:PMC8616957)

Zanetti, C. et al. (2021) The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13. Blood, 138(19), pp. 1870-1884. (doi: 10.1182/blood.2021011557) (PMID:34424946)

Halsey, C. and Escherich, G. (2021) A “Goldilocks” approach to CNS leukaemia is needed. Blood, 138(4), pp. 288-289. (doi: 10.1182/blood.2021011461) (PMID:34323942)

Andrés-Jensen, L. et al. (2021) Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia. Lancet Haematology, 8(7), e513-e523. (doi: 10.1016/S2352-3026(21)00136-8) (PMID:34171282)

Shi, Y. et al. (2021) Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia. Haematologica, 106(4), pp. 1056-1066. (doi: 10.3324/haematol.2019.241026) (PMID:32139432) (PMCID:PMC8018112)

Lenk, L. et al. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, 73. (doi: 10.1038/s42003-020-01591-z) (PMID:33452446) (PMCID:PMC7810877)

Savino, A. M. et al. (2020) Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on Stearoyl CoA desaturase. Nature Cancer, 1(10), pp. 998-1009. (doi: 10.1038/s43018-020-00115-2) (PMID:33479702) (PMCID:PMC7116605)

Abdelrasoul, H. et al. (2020) Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11, 3194. (doi: 10.1038/s41467-020-16927-w) (PMID:32581241) (PMCID:PMC7314847)

Walker, D. A., Meijer, L., Coyle, B. and Halsey, C. (2020) Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials. Lancet Child and Adolescent Health, 4(3), pp. 242-250. (doi: 10.1016/S2352-4642(19)30333-5) (PMID:31958415)

Forster, V. J., Bell, G. and Halsey, C. (2020) Should nitrous oxide ever be used in oncology patients receiving methotrexate therapy? Pediatric Anesthesia, 30(1), pp. 9-16. (doi: 10.1111/pan.13760) (PMID:31667903)

Yousafzai, Y. M. et al. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, 10623. (doi: 10.1016/j.leukres.2019.106232) (PMID:31706196)

Matheson, E. C. et al. (2019) Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM. Haematologica, 104(9), pp. 1804-1811. (doi: 10.3324/haematol.2017.185975) (PMID:30655370) (PMCID:PMC6717586)

Baquero, P. et al. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33(4), pp. 981-994. (doi: 10.1038/s41375-018-0252-4) (PMID:30185934) (PMCID:PMC6292500)

Alsadeq, A. et al. (2018) IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, 132(15), pp. 1614-1617. (doi: 10.1182/blood-2018-04-844209) (PMID:30154115) (PMCID:PMC6238156)

Halsey, C. (2018) Challenging "privileged" stereotypes - leukemic blasts and the central nervous system. Leukemia Research, 73, pp. 76-77. (doi: 10.1016/j.leukres.2018.08.013) (PMID:30243134)

Wilson, R., Osborne, C. and Halsey, C. (2018) The use of Ommaya reservoirs to deliver central nervous system directed chemotherapy in childhood acute lymphoblastic leukaemia. Pediatric Drugs, 20(4), pp. 293-301. (doi: 10.1007/s40272-018-0298-9) (PMID:29850985)

Forster, V., Escherich, G. and Halsey, C. (2018) Comment on: Successful use of nitrous oxide during lumbar punctures: a call for nitrous oxide in pediatric oncology clinics. Pediatric Blood and Cancer, 65(5), e26930. (doi: 10.1002/pbc.26930) (PMID:29286566)

De Santo, C. et al. (2018) The arginine metabolome in Acute Lymphoblastic Leukemia can be targeted by the PEG-recombinant Arginase I BCT-100. International Journal of Cancer, 142(7), pp. 1490-1502. (doi: 10.1002/ijc.31170) (PMID:29168171) (PMCID:PMC5849425)

Sinclair, P. B. et al. (2018) Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Haematologica, 103(4), pp. 634-644. (doi: 10.3324/haematol.2017.172304) (PMID:29449437) (PMCID:PMC5865429)

Bartram, J., Goulden, N., Wright, G., Adams, S., Brooks, T., Edwards, D., Inglott, S., Yousafzai, Y., Hubank, M. and Halsey, C. (2018) High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments. Haematologica, 103, e113. (doi: 10.3324/haematol.2017.174987) (PMID:29217777)

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2017) Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect. Cancer Chemotherapy and Pharmacology, 79(4), pp. 841-842. (doi: 10.1007/s00280-017-3270-4) (PMID:28289862)

Oruganti, S.R., Torres, D.J., Krebsbach, S., Asperti-Boursin, F., Winters, J., Matlawska-Wasowska, K., Winter, S.S., Halsey, C. and Cannon, J.L. (2017) CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia, 31(1), pp. 255-258. (doi: 10.1038/leu.2016.272) (PMID:27698445)

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2016) Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer Chemotherapy and Pharmacology, 78(5), pp. 1093-1096. (doi: 10.1007/s00280-016-3153-0) (PMID:27659182) (PMCID:PMC5083755)

Schmiegelow, K. et al. (2016) Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncology, 17(6), e231-e239. (doi: 10.1016/S1470-2045(16)30035-3)

Williams, M. T.S. et al. (2016) The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukaemia blasts. Blood, 127, 16. (doi: 10.1182/blood-2015-08-665034) (PMID:26869395)

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E. and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi: 10.1016/j.semcdb.2015.09.008) (PMID:26365277)

Irving, J. et al. (2014) Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood, 124(23), pp. 3420-3430. (doi: 10.1182/blood-2014-04-531871) (PMID:25253770) (PMCID:PMC4246039)

Winter, S. and Halsey, C. (2014) Should children presenting with iron deficiency anaemia be screened for coeliac disease? Archives of Disease in Childhood, 99(2), pp. 180-182. (doi: 10.1136/archdischild-2013-305591)

El-Fakhri, N., McDevitt, H., Shaikh, M.G., Halsey, C. and Ahmed, S.F. (2014) Vitamin D and its effects on glucose homeostasis, cardiovascular function and immune function. Hormone Research in Paediatrics, 81(6), pp. 363-378. (doi: 10.1159/000357731)

Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970) (PMID:24700781)

Roberts, I. et al. (2013) GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Blood, 122(24), pp. 3908-3917. (doi: 10.1182/blood-2013-07-515148)

Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)

Halsey, C. , Buck, G., Richards, S., Vargha-Khadem, F., Hill, F. and Gibson, B. (2011) The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI. Journal of Hematology and Oncology, 4(42), (doi: 10.1186/1756-8722-4-42)

Halsey, C. , Lumley, H. and Luckit, J. (2010) Necrotising external otitis caused by Aspergillus wentii: a case report. Mycoses, 54(4), E211-E213. (doi: 10.1111/J.1439-0507.2009.01815.x)

Halsey, C. , Tunstall, O., Gibson, B., Roberts, I. and Graham, G. (2010) Role of GATA-1s in early hematopoiesis and differences between alternative splicing in human and murine GATA-1. Blood, 115(16), pp. 3415-3416. (doi: 10.1182/blood-2010-02-267930)

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi: 10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)

Jiskoot, P.M.C., Halsey, C. , Rivers, R., Bain, B.J. and Wilkins, B.S. (2004) Unusual splenic sinusoidal iron overload in sickle cell/haemoglobin D-Punjab disease. Journal of Clinical Pathology, 57(5), pp. 539-540. (doi: 10.1136/jcp.2002.004481) (PMID:15113864) (PMCID:PMC1770290)

Ronghe, M. D., Halsey, C. and Goulden, N. J. (2003) Anticoagulation therapy in children. Pediatric Drugs, 5(12), pp. 803-820. (doi: 10.2165/00148581-200305120-00004) (PMID:14658922)

Amrolia, P. J., Almeida, A., Halsey, C. , Roberts, I. A. G. and Davies, S. C. (2003) Therapeutic challenges in childhood sickle cell disease part 1: current and future treatment options. British Journal of Haematology, 120(5), pp. 725-736. (doi: 10.1046/j.1365-2141.2003.04143.x) (PMID:12614202)

Halsey, C. and Roberts, I. A.G. (2003) The role of hydroxyurea in sickle cell disease. British Journal of Haematology, 120(2), pp. 177-186. (doi: 10.1046/j.1365-2141.2003.03849.x) (PMID:12542474)

Book Sections

Halsey, C. (2014) Haematological investigations in paediatrics. In: Goal, K.M. and Carachi, R. (eds.) Hutchison's Atlas of Paediatric Physical Diagnosis. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9789351521525

Halsey, C. (2014) Towards personalised medicine in childhood acute lymphoblastic leukaemia. In: Thomas, A.E. and Halsey, C. (eds.) Controversies in Pediatric and Adolescent Hematology. Kerger, pp. 98-115. ISBN 9783318024234 (doi: 10.1159/000350349)

Halsey, C. and Chalmers, E.A. (2009) Haematalogical investigations in children. In: Goel, K. and Gupta, D. (eds.) Hutchison's Paediatrics. Jaypee Brothers, Medical Publishers (P) Ltd.. ISBN 9788184485868

Halsey, C.,. and Chalmers, E.A. (2008) Haematological investigations in paediatrics. In: Goel, K.M. and Gupta, D.K. (eds.) Hutchison's Paediatrics. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9788184485868

Halsey, C. and Roberts, I. (2008) Neonatal Haematology. In: Forfar, J.O. and McIntosh, N. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443103971

Gibson, B. E.S. and Halsey, C. (2006) Nonimmune neonatal anemias. In: Arceci, R., Hann, I. M. and Smith, O. P. (eds.) Pediatric Hematology. Blackwell Publishing: Malden, pp. 130-150. ISBN 9781405134002 (doi: 10.1002/9780470987001.ch7)

Halsey, C. and Roberts, I. (2003) haemopoietic stem cell transplantation for thalassaemia and sickle cell disease. In: Okpala, I.E. (ed.) Comprehensive Care of Sickle Cell Disease. UNSPECIFIED.

Halsey, C. and Roberts, I. (2003) Neonatal Haematology. In: Forfar, J.O., Arneil, G.C., McIntosh, N., Helms, P. and Smyth, R.L. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443071980

Edited Books

Thomas, A.E. and Halsey, C. (2014) Controversies in Pediatric and Adolescent Hematology. Series: Pediatric and Adolescent Medicine. Karger. ISBN 9783318024227

Research Reports or Papers

Welisch, G. et al. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? Project Report. OSF. (doi: 10.17605/OSF.IO/KWHQF).

Conference or Workshop Item

Cousins, A. F., Olivares, O., Michie, A. M. , Gottlieb, E. and Halsey, C. (2017) Association of CNS Involvement in Childhood Acute Lymphoblastic Leukaemia with Cholesterol Biosynthesis Upregulation. Spring Meeting for Clinician Scientists in Training 2017, London, UK, 23 Feb 2017. S35. (doi: 10.1016/S0140-6736(17)30431-2)

Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.

Conference Proceedings

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

This list was generated on Sun May 28 17:43:48 2023 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Isolating a CML-like patient group in Ph+ ALL - does this alter management?
    Children's Cancer and Leukaemia Group
    2023 - 2026
     
  • ECMC QQR 2023-2028
    Cancer Research UK
    2023 - 2024
     
  • Translating the CML-like Ph+ALL population into clinical practice
    Beatson Cancer Charity
    2023 - 2026
     
  • Targeting metabolic reprogramming to develop novel strategies for CNS-directed therapy in acute lymphoblastic leukaemia
    Cancer Research UK
    2022 - 2028
     
  • Neurotoxicity Genotyping Project
    NHS Greater Glasgow and Clyde
    2021 - 2022
     
  • Using state of the art lipidomic approaches to understand how acute lymphoblastic leukaemia cells adapt to the central nervous system niche
    Wellcome Trust
    2021 - 2022
     
  • Identifying drivers of central nervous system involvement in T-cell acute lymphoblastic leukaemia
    Children's Cancer and Leukaemia Group
    2021 - 2023
     
  • ALLTogether1 CSF-FLOW sub-study
    Children's Cancer and Leukaemia Group
    2021 - 2024
     
  • DEVELOPING LEUKAEMIC BIOMARKERS TO ENABLE PERSONALISED CNSDIRECTED THERAPY
    Yorkhill Leukaemia & Cancer Research Fund
    2020 - 2021
     
  • Supporting Neurodiversity in the Workplace
    Wellcome Trust
    2020 - 2022
     
  • 14-170 Biomarkers and discovery of new therapeutic targets for chemotherapy associated neurotoxicity
    Children with Cancer UK
    2019 - 2023
     
  • Unravelling clinical heterogeneity in Philadelphia positive ALL
    Children's Cancer and Leukaemia Group
    2019 - 2022
     
  • Unravelling clinical heterogeneity in Philadelphia positive ALL
    Children's Cancer and Leukaemia Group
    2019 - 2022
     
  • ECMC supplement
    Chief Scientist Office
    2019 - 2020
     
  • Reversal of Glucocorticoid resistance in high risk T-ALL
    Action Medical Research
    2018 - 2022
     
  • Developing Leukaemic Biomarkers to Enable Personalised CNS-directed Therapy
    UK Children's Cancer Study Group
    2017 - 2020
     
  • Defining the tumour microenvironment in extramedullary acute leukaemia
    Children's Cancer and Leukaemia Group
    2017 - 2018
     
  • Glasgow ECMC
    Cancer Research UK
    2017 - 2019
     
  • Glasgow ECMC
    Chief Scientist Office
    2017 - 2018
     
  • Deciphering Neurotoxicity During All Therapy Using A Deep Phenotyping-Genotyping Approach
    Glasgow Children`s Hospital Charity
    2017 - 2020
     
  • Biomarkers and discovery of new therapeutic targets for chemotherapy associated neurotoxicity
    Children with Cancer UK
    2015 - 2018
     
  • Identifying Novel Targets for eradication of acute lymphoblastic leukaemia in the central nervous system
    Chief Scientist Office
    2015 - 2017
     
  • Developing single-cell tracking techniques in order to understand how leukaemic cells infiltrate the brain in childhood acute lymphoblastic leukaemia
    Tenovus Scotland
    2014 - 2016
     
  • Development of a humanised murine model of central nervous system leukaemia
    Glasgow Children`s Hospital Charity
    2013 - 2015
     
  • An Investigation of Immune Function in Children with Symptomatic Vitamin D Deficiency.
    Tenovus Scotland
    2012 - 2014
     
  • An investigation of the molecular basis for acute lymphoblastic leukaemia cell migration to the central nervous system
    Glasgow Children`s Hospital Charity
    2011 - 2013
     
  • An investigation into the molecular basis for B lineage acute lymphoblastic leukaemia migration to extramedullary sites.rn
    The Kay Kendall Leukaemia Fund
    2010 - 2013
     
  • A Molecular Characterisation of Central Nervous System Leukaemia
    Chief Scientist Office
    2010 - 2011
     
  • Scottish Senior Clinical Fellowship Scheme
    Scottish Funding Council
    2010 - 2014
     
  • Understanding the Causes of Central Nervous System Leukaemia
    British Society for Haematology
    2009 - 2010
     

Research datasets

Jump to: 2022 | 2021
Number of items: 2.

2022

ROSS, K. , Keith, N. , Abbott, L., Adams, C., Aitken, E., Aslett, O., Basra, S., Bell, I., Bradley, J., Brown, T., Brown, W., Chen, R., Cheskin, L., Corrie, R., de Vries, E., Defty, E., Drake, H., Dunlop, H., Emadi, A. , Evans, J. , Everett, S., Feng, Z., Fraser, A., Gallacher, K. , Gaynor-Kirk, E., Halsey, C. , Harris, F., Hu, J., Hush, G., Jamieson, N. , Jameison, V., Jones, R. , Just, L., Lembo, T. , Lloyd, B., Ma, C.-L., Macdonald, S. , Mathias, M. , McAra, M., McCaffrey, B., Mccluskey, L.-A., Mchattie, L.-S., Mcneill, E., Milliken, A., Mogford, D., Morris, G., Nicoll, M., O'Brien, T., Onwuka, T., Papanastasatou, M., Perry, M. , Prosser, Z., Proudfoot, B., Raman Komnedath, S., Robinson, J. , Sleight, R., Smith, P., Stricevic, M., Tharp, B., Thoresson, V., Thorne, J., Vansteenhouse, H., Welisch, G. and Wu, O. (2022) Symbiotic Futures: Health, Well-being and Care in the Post-Covid World. [Data Collection]

2021

Ross, K., Keith, N. , Jones, R. , Hanna, C. , Afzal, I., Basra, S., Bell, I., Bennie, M., Berger, A., Bilsland, A., Blyth, K. , Borris, A., Boruc, M., Bradley, J., Caryl, J., Cerniauskaite, U., Cheskin, L., Chiwanda, J., Cooper, J. , Debiasse, K., Fegan, S., Ferguson, C., Halsey, C. , Harris, F., Herceg, Z., Hogg, C., Hush, G., Julien, A., Kameda, R., Keith, A., Kelly, J., Konieczna, Z., Lu, M. Y., Mackay, S., Marinescu-Duca, M., Maxwell, M., McCaffrey, R., McGuire, N., McIntyre, D., Moffat-Kyle, T., Mukherjee, L., O'Friel, A., Perry, M. , Prentice, J., Prosser, Z., Proudfoot, B., Raman, S., Robinson, J. , Smith, A., Stewart, S., Stricevic, M., Teal, G., Thomson, H., Wang, Z., Welisch, G., Wu, O. , Wu, H., Young, E. and Young, S. (2021) The Future of Cancer and Collective Intelligence in the Post-Covid World. [Data Collection]

This list was generated on Sun May 28 17:43:50 2023 BST.

Christina Halsey