Schools

Hall-Younger, E., Tait, S. W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94, (doi: 10.1016/j.ceb.2025.102510)

Dobbin, S. J. H., Mangion, K., Berry, C., Roditi, G., Basak, S., McClure, J. D., Brooksbank, K., Sonecki, P., Sourbron, S., Evans, J., White, J., Welsh, P., Butler, E., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2025) Vascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging. Heart, (doi: 10.1136/heartjnl-2024-325535)

Bone, M., Schreyer, D., Treanor-Taylor, M., Proby, C., Harwood, C., Leigh, I. M., Bailey, P., Inman, G. (2025) The landscape of long non-coding RNA during cSCC progression. British Journal of Dermatology,

Hurley, R., Osbourne, J., Inman, G. J., Conway, D. I., Paterson, C., Douglas, C. (2025) Pre-treatment serum prognostic scores and survival in curatively treated laryngeal cancer. Laryngoscope Investigative Otolaryngology,

White, S. E., Schwartze, T. A., Mukundan, A., Schoenherr, C., Singh, S. P., van Dinther, M., Cunningham, K. T., White, M. P. J., Campion, T., Pritchard, J., Hinck, C. S., ten Dijke, P., Inman, G. J., Maizels, R. M., Hinck, A. P. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16, (doi: 10.1038/s41467-025-56954-z)

Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z)

Pinar, S. A., McGuigan, M.-C., Duthie, F., Ezhil, A., Holroyd, D., Jamieson, N. B. (2025) A case report of sarcomatoid carcinoma of the common bile duct with a review of the literature. World Journal of Surgical Oncology,

Hurley, R., Paterson, C., Conway, D. I., Inman, G. J., Douglas, C. M. (2025) Laryngeal cancer in the West of Scotland 2014–2020: trends and survival in a cohort of 867 patients. Laryngoscope, (doi: 10.1002/lary.31992)

Rangelova, E. et al. (2024) The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study. Annals of Oncology, (doi: 10.1016/j.annonc.2024.12.015)

Walker, M., Morton, J. P. (2024) Hydrogel models of pancreatic adenocarcinoma to study cell mechanosensing. Biophysical Reviews, (doi: 10.1007/s12551-024-01265-8)

MacDonald, L. et al. (2024) Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis. Immunity, 57, pp. 2843-2862.e12. (doi: 10.1016/j.immuni.2024.11.004)

Li, C., Liu, Q., Han, L., Zhang, H., Immler, R., Rathkolb, B., Secklehner, J., de Angelis, M. H., Yildirim, A. Ö., Zeuschner, D., Nicke, A., Carlin, L. M., Sperandio, M., Stoeger, T., Rehberg, M. (2024) The eATP/P2×7R Axis drives quantum dot-nanoparticle induced neutrophil recruitment in the pulmonary microcirculation. Advanced Science, 11, (doi: 10.1002/advs.202404661)

Singh, S. P., Smyth, D. J., Cunningham, K. T., Mukundan, A., Byeon, C.-H., Hinck, C. S., White, M. P.J., Ciancia, C., Wąsowska, N., Sanders, A., Jin, R., White, R. F., Lilla, S., Zanivan, S., Schoenherr, C., Inman, G., van Dinther, M., ten Dijke, P., Hinck, A. P., Maizels, R. M. (2024) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, (doi: 10.1038/s44319-024-00323-2)

Liu, D., Young, F., Lamb, K. D., Claudio Quiros, A., Pancheva, A., Miller, C., Macdonald, C., Robertson, D. L., Yuan, K. (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)

Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, (doi: 10.1038/s41556-024-01543-3)

Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)

McGuigan, M.-C., Hadjicosti, R., Cameron, A. J., Coats, M., Chang, D., Dickson, E. J., Holroyd, D., McKay, C. J., Jamieson, N. B. (2024) The surveillance strategy for Intraductal Pancreatic Mucinous Neoplasms: Criteria for discontinuation. Annals of Surgery, (doi: 10.1097/SLA.0000000000006580)

Lucocq, J. et al. (2024) Precursor epithelial subtypes of adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN): clinicopathological features, recurrence and response to adjuvant chemotherapy. Annals of Surgical Oncology, 31, pp. 7023-7032. (doi: 10.1245/s10434-024-15677-z)

Smith, C. D.L., McMahon, A. D., Purkayastha, M., Creaney, G., Clements, K., Inman, G. J., Bhatti, L. A., Douglas, C. M., Paterson, C., Conway, D. I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020) BJC Reports, 2, (doi: 10.1038/s44276-024-00089-z)

Strathearn, L. S., Spender, L. C., Schoenherr, C., Mason, S., Edwards, R., Blyth, K., Inman, G. (2024) C1orf106 (INAVA) is a SMAD3-dependent TGF-β target gene that promotes clonogenicity and correlates with poor prognosis in breast cancer. Cells, 13, (doi: 10.3390/cells13181530)

Churchhouse, A. M.D., Billard, C. V., Suzuki, T., Pohl, S. O.G., Donnelly, K., Nixon, C., Arends, M. J., Din, S., Kirkwood, K., Marques Junior, J., Von Kriegsheim, A., Coffelt, S. B., Myant, K. B. (2024) Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression. Oncogene, 43, pp. 3094-3107. (doi: 10.1038/s41388-024-03135-9)

Smith, C. D.L., McMahon, A. D., Lyall, D. M., Goulart, M., Inman, G., Ross, A., Gormley, M., Dudding, T., Macfarlane, G. J., Robinson, M., Richiardi, L., Serraino, D., Polesel, J., Canova, C., Ahrens, W., Healy, C. M., Lagiou, P., Holcatova, I., Alemany, L., Znoar, A., Waterboer, T., Brennan, P., Virani, S., Conway, D. I. (2024) Development and external validation of a head and neck cancer risk prediction model. Head and Neck, 46, pp. 2261-2273. (doi: 10.1002/hed.27834)

Glover, H. L., Schreiner, A., Dewson, G., Tait, S. W.G. (2024) Mitochondria and cell death. Nature Cell Biology, 26, pp. 1434-1446. (doi: 10.1038/s41556-024-01429-4)

Dannhorn, A., Kazanc, E., Flint, L., Guo, F., Carter, A., Hall, A. R., Jones, S. A., Poulogiannis, G., Barry, S. T., Sansom, O. J., Bunch, J., Takats, Z., Goodwin, R. J.A. (2024) Morphological and molecular preservation through universal preparation of fresh-frozen tissue samples for multimodal imaging workflows. Nature Protocols, 19, pp. 2685-2716. (doi: 10.1038/s41596-024-00987-z)

Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L. C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A. H.Y., Schofield, C. J., von Kriegsheim, A., Marsh, J. A., Pavet, V., Sansom, O. J., Illingworth, R. S., Patton, E. E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.114406)

Pereira, B. A. et al. (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10, (doi: 10.1126/sciadv.adl1197)

McKenzie, M., Lian, G.-Y., Pennel, K. A.F., Quinn, J. A., Jamieson, N. B., Edwards, J. (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10, (doi: 10.1016/j.heliyon.2024.e32904)

Stankey, C.T. et al. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630, pp. 447-456. (doi: 10.1038/s41586-024-07501-1)

Kumar, S., Basto, A. P., Ribeiro, F., Almeida, S. C.P., Campos, P., Peres, C., Pulvirenti, N., Al-Khalidi, S., Kilbey, A., Tosello, J., Piaggio, E., Russo, M., Gama-Carvalho, M., Coffelt, S. B., Roberts, E. W., Geginat, J., Florindo, H. F., Graca, L. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, (doi: 10.1038/s41421-024-00681-0)

Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, (doi: 10.1038/s41588-024-01809-4)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1)

Sumaria, N., Fiala, G. J., Inácio, D., Curado-Avelar, M., Cachucho, A., Pinheiro, R., Wiesheu, R., Kimura, S., Courtois, L., Blankenhaus, B., Darrigues, J., Suske, T., Almeida, A. R. M., Minguet, S., Asnafi, V., Lhermitte, L., Mullighan, C. G., Coffelt, S. B., Moriggl, R., Barata, J. T., Pennington, D. J., Silva-Santos, B. (2024) Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms. Nature Immunology, (doi: 10.1038/s41590-024-01855-4)

Boey, A., Bryce, A., Dickson, E., Coats, M., McKay, C., Jamieson, N., Chang, D., Holroyd, D., Dreyer, S. (2024) The Impact of Pre-operative Indeterminate Lung Nodules in the Surgical Management of Pancreatic Ductal Adenocarcinoma. (doi: 10.1016/j.hpb.2024.03.269)

Matchett, K. P. et al. (2024) Multimodal decoding of human liver regeneration. Nature, 630, pp. 158-165. (doi: 10.1038/s41586-024-07376-2)

Robertson, F. P., Cameron, A., Spiers, H. V.M., Joseph, N., Taylor, E., Ratnayake, B., Jamieson, N. B., Pandanaboyana, S. (2024) Evidence for molecular subtyping in pancreatic ductal adenocarcinoma: A systematic review. HPB, 26, pp. 609-617. (doi: 10.1016/j.hpb.2024.02.001)

Casolino, R., Beer, P. A., Chakravarty, D., Davis, M. B., Malapelle, U., Mazzarella, L., Normanno, N., Pauli, C., Subbiah, V., Turnbull, C., Westphalen, C. B., Biankin, A. V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74, pp. 264-285. (doi: 10.3322/caac.21825)

Ahmed Hassan Elshiekh, A., Tait, S. W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18, pp. 1054-1057. (doi: 10.1002/1878-0261.13627)

Cooke, S. F., Wright, T. A., Sin, Y. Y., Ling, J., Kyurkchieva, E., Phanthaphol, N., McSkimming, T., Herbert, K., Rebus, S., Biankin, A. V., Chang, D. K., Baillie, G. S., Blair, C. M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, (doi: 10.1038/s41598-024-59451-3)

Pennel, K., Dutton, L., Melissourgou-Syka, L., Roxburgh, C., Birch, J., Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, (doi: 10.1017/erm.2024.15)

Malviya, G., Lannagan, T. R.M., Johnson, E., Mackintosh, A., Bielik, R., Peters, A., Soloviev, D., Brown, G., Jackstadt, R., Nixon, C., Gilroy, K., Campbell, A., Sansom, O. J., Lewis, D. Y. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30, pp. 1518-1529. (doi: 10.1158/1078-0432.ccr-23-1063)

Lupo, F., Coffelt, S. B. (2024) Stressed out neutrophils drive metastasis. Immunity, 57, pp. 840-842. (doi: 10.1016/j.immuni.2024.03.013)

Lucocq, J. et al. (2024) Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study. British Journal of Surgery, 111, (doi: 10.1093/bjs/znae100)

Agostini, A., Piro, G., Inzani, F., Quero, G., Esposito, A., Caggiano, A., Priori, L., Larghi, A., Alfieri, S., Casolino, R., Scaglione, G., Tondolo, V., Cammarota, G., Ianiro, G., Corbo, V., Biankin, A. V., Tortora, G., Carbone, C. (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15, (doi: 10.1038/s41467-024-46994-2)

Lucocq, J. et al. (2024) Long-term outcomes following resection of Adenocarcinoma arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) versus Pancreatic Ductal Adenocarcinoma (PDAC): a propensity-score matched analysis. Annals of Surgery, (doi: 10.1097/SLA.0000000000006272)

Nair, R., Lannagan, T. R.M., Jackstadt, R., Andrusaite, A., Cole, J., Boyne, C., Nibbs, R. J.B., Sansom, O. J., Milling, S. (2024) Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance. OncoImmunology, 13, (doi: 10.1080/2162402X.2024.2330194)

Dickson, A. L., Zickuhr, G. M., Um, I. H., Zhang, Y., Plummer, R., Blagden, S. P., Symeonides, S. N., Cook, N., Evans, T.R. J., Elshani, M., Harrison, D. J. (2024) Exposing the heterogeneity of the lipidome in the TME of cutaneous melanoma following treatment with NUC-7738 in combination with anti-PD-1 therapy. (doi: 10.1158/1538-7445.am2024-6222)

Domingo, E. et al. (2024) Prognostic and predictive value of Immunoscore in stage III colorectal cancer: pooled analysis of 2,608 cases from the SCOT and IDEA-HORG studies. Journal of Clinical Oncology, (doi: 10.1200/JCO.23.01648)

Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J., Sansom, O. J., O'Neill, E., Jones, K., Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050463)

Sacco, J. J., Jackson, R., Corrie, P., Danson, S., Evans, J., Ochsenreither, S., Kumar, S., Goodman, A., Larkin, J., Karydis, I., Steven, N., Lorigan, P., Plummer, R., Patel, P., Psarelli, E., Olsson-Brown, A., Shaw, H., Leyvraz, S., Handley, L., Rawcliffe, C., Nathan, P. (2024) A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma. European Journal of Cancer, 202, (doi: 10.1016/j.ejca.2024.114009)

Zhang, S. et al. (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10, (doi: 10.1038/s41420-024-01890-y)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, (doi: 10.1186/s13046-024-02958-4)

Santi, A., Kay, E. J., Neilson, L. J., McGarry, L., Lilla, S., Mullin, M., Paul, N. R., Fercoq, F., Koulouras, G., Rodriguez Blanco, G., Athineos, D., Mason, S., Hughes, M., Thomson, G., Kieffer, Y., Nixon, C., Blyth, K., Mechta-Grigoriou, F., Carlin, L. M., Zanivan, S. (2024) Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science Signaling, 17, (doi: 10.1126/scisignal.ade0580)

O’Rourke, C. J. et al. (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73, pp. 496-508. (doi: 10.1136/gutjnl-2023-330748)

Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, pp. 458-472. (doi: 10.1038/s41588-024-01654-5)

Riviere, D., Aarntzen, E., van Geenen, E., Chang, D., de Geus-Oei, L.-F., Brosens, L., van Laarhoven, K., Gotthardt, M., Hermans, J. (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26, pp. 389-399. (doi: 10.1016/j.hpb.2023.11.010)

McGovern, J., Mackay, C., Freireich, R., Golder, A. M., Dolan, R. D., Horgan, P. G., Holroyd, D., Jamieson, N. B., McMillan, D. C. (2024) The relationship between liver volume, clinicopathological characteristics and survival in patients undergoing resection with curative intent for non-metastatic colonic cancer. Tomography, 10, pp. 349-359. (doi: 10.3390/tomography10030027)

Bryce, A., Dreyer, S., Dolan, R., Froeling, F., Chang, D. (2024) Host phenotypic adversity independently predicts progression to resection in neoadjuvantly-treated pancreatic cancer. (doi: 10.1016/j.ejso.2023.107753)

Dreyer, S., Bryce, A., Australian Pancreatic Cancer Genome Initiative, , Biankin, A., Jamieson, N., Chang, D. (2024) The clinical and molecular landscape of early onset pancreatic cancer. (doi: 10.1016/j.ejso.2023.107348)

Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S., Tait, S. W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43, pp. 904-930. (doi: 10.1038/s44318-024-00044-1)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, (doi: 10.1038/s41467-024-45471-0)

Fetit, R., McLaren, A. S., White, M., Mills, M. L., Falconer, J., Cortes-Lavaud, X., Gilroy, K., Lannagan, T. R.M., Ridgway, R. A., Nixon, C., Naiker, V., Njunge, R., Clarke, C., Whyte, D., Kirschner, K., Jackstadt, R., Norman, J., Carlin, L. M., Campbell, A. D., Sansom, O. J., Steele, C. W. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4, pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319)

Frei, A. L. et al. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25, pp. 198-211. (doi: 10.1016/S1470-2045(23)00560-0)

Shamis, S. A. K., Savioli, F., Ammar, A., Al-Badran, S. S.F., Hatthakarnkul, P., Leslie, H., Mallon, E., Jamieson, N. B., McMillan, D. C., Edwards, J. (2024) Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay. Histology and Histopathology: Cellular and Molecular Biology, 39, pp. 177-200. (doi: 10.14670/HH-18-655)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210)

Wang, J., Harwood, C. A., Bailey, E., Bewicke-Copley, F., Anene, C. A., Thomson, J., Qamar, M. J., Laban, R., Nourse, C., Schoenherr, C., Treanor-Taylor, M., Healy, E., Lai, C., Craig, P., Moyes, C., Rickaby, W., Martin, J., Proby, C., Inman, G. J., Leigh, I. M. (2023) Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. Journal of the American Academy of Dermatology, 89, pp. 1159-1166. (doi: 10.1016/j.jaad.2023.08.012)

Neilson, L. J., Cartwright, D., Risteli, M., Jokinen, E. M., McGarry, L., Sandvik, T., Nikolatou, K., Hodge, K., Atkinson, S., Vias, M., Kay, E. J., Brenton, J. D., Carlin, L. M., Bryant, D. M., Salo, T., Zanivan, S. (2023) Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment. Matrix Biology Plus, 19-20, (doi: 10.1016/j.mbplus.2023.100136)

Malik, N., Hay, J., Almuhanna, H. N.B., Dunn, K. M., Lees, J., Cassels, J., Li, J., Nakagawa, R., Sansom, O. J., Michie, A. M. (2023) mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia. Leukemia, 37, pp. 2414-2425. (doi: 10.1038/s41375-023-02043-3)

McLaren, A. S., Spoor, J. A., Cartwright, D., Naylor, G., Barclay, S., Priest, M., Puttagunta, S., Armstrong, K., Ballantyne, S., Stanley, A., Evans, T. R. J., West of Scotland HCC MDT, (2023) Impact of the COVID-19 pandemic on patients with hepatocellular carcinoma in the west of Scotland: a cohort study. BMJ Open Gastroenterology, 10, (doi: 10.1136/bmjgast-2023-001231)

Zarou, M. M., Dawson, A., Prasad, B., Bittencourt-Silvestre, J., Zerbst, D., Rodriguez Blanco, G., Scott, M., Dunn, K., Krishnan, V., Copland, M., Vetrie, D., Bhatia, R., Coffelt, S., Ong, S. T., Wheadon, H., Zanivan, S., Kirschner, K., Helgason, G. V. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. (doi: 10.1182/blood-2023-181630)

Frei, A. L. et al. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9, pp. 449-463. (doi: 10.1002/cjp2.342)

Lucocq, J. et al. (2023) Risk of recurrence after surgical resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia (IPMN) with patterns of distribution and treatment. Annals of Surgery, 280, pp. 126-135. (doi: 10.1097/sla.0000000000006144)

Victorelli, S. et al. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622, pp. 627-636. (doi: 10.1038/s41586-023-06621-4)

Holt, A. K., Najumudeen, A. K., Collard, T. J., Li, H., Millett, L. M., Hoskin, A. J., Legge, D. N., Mortensson, E. M.H., Flanagan, D. J., Jones, N., Kollareddy, M., Timms, P., Hitchings, M. D., Cronin, J., Sansom, O. J., Williams, A. C., Vincent, E. E. (2023) Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition. Cancer and Metabolism, 11, (doi: 10.1186/s40170-023-00318-y)

Hewitt, R. J., Puttur, F., Gaboriau, D. C.A., Fercoq, F., Fresquet, M., Traves, W. J., Yates, L. L., Walker, S. A., Molyneaux, P. L., Kemp, S. V., Nicholson, A. G., Rice, A., Roberts, E., Lennon, R., Carlin, L. M., Byrne, A. J., Maher, T. M., Lloyd, C. M. (2023) Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis. Nature Communications, 14, (doi: 10.1038/s41467-023-41621-y)

Golan, T., Casolino, R., Biankin, A. V., Hammel, P., Whitaker, K. D., Hall, M. J., Riegert-Johnson, D. L. (2023) Germline BRCA testing in pancreatic cancer: improving awareness, timing, turnaround, and uptake. Therapeutic Advances in Medical Oncology, (doi: 10.1177/17588359231189127)

Nikolatou, K., Sandilands, E., Román-Fernández, A., Cumming, E. M., Freckmann, E., Lilla, S., Buetow, L., McGarry, L., Neilson, M., Shaw, R., Strachan, D., Miller, C., Huang, D. T., Mcneish, I. A., Norman, J. C., Zanivan, S., Bryant, D. M. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, (doi: 10.15252/embj.2023113987)

Haddad, T. S., van den Dobbelsteen, L., Öztürk, S. K., Geene, R., Nijman, I. J., Verrijp, K., Jamieson, N. B., Wood, C., van Vliet, S., Reuvers, L., Achouiti, S., Rutgers, N., Brouwer, N., Simmer, F., Zlobec, I., Lugli, A., Nagtegaal, I. D. (2023) Pseudobudding: ruptured glands do not represent true tumor buds. Journal of Pathology, 261, pp. 19-27. (doi: 10.1002/path.6146)

Quintana, J. F., Sinton, M. C., Chandrasegaran, P., Lestari, A. N., Heslop, R., Cheaib, B., Ogunsola, J., Ngoyi, D. M., Swar, N.-R. K., Cooper, A., Mabbott, N. A., Coffelt, S. B., MacLeod, A. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, (doi: 10.1038/s41467-023-40962-y)

Bailey, P., Ridgway, R. L., Cammareri, P., Treanor-Taylor, M., Bailey, U.-M., Schoenherr, C., Bone, M., Schreyer, D., Purdie, K., Thomson, J., Rickaby, W., Jackstadt, R., Campbell, A. D., Dimonitsas, E., Stratigos, A. J., Arron, S. T., Wang, J., Blyth, K., Proby, C. M., Harwood, C. A., Sansom, O. J., Leigh, I. M., Inman, G. J. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, (doi: 10.1038/s41467-023-40822-9)

Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11, pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5, pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0)

Kristeleit, R., Plummer, R., Jones, R., Carter, L., Blagden, S., Sarker, D., Arkenau, T., Evans, T. R. J., Danson, S., Symeonides, S. N., Veal, G. J., Klencke, B. J., Kowalski, M. M., Banerji, U. (2023) A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer, 129, pp. 38-45. (doi: 10.1038/s41416-023-02279-x)

Kania, E., Long, J. S., McEwan, D. G., Welkenhuyzen, K., La Rovere, R., Luyten, T., Halpin, J., Lobbestael, E., Baekelandt, V., Bultynck, G., Ryan, K. M., Parys, J. B. (2023) LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner. Cell Death and Disease, 14, (doi: 10.1038/s41419-023-05964-0)

Solovyeva, O., Dimairo, M., Weir, C. J., Hee, S. W., Espinasse, A., Ursino, M., Patel, D., Kightley, A., Hughes, S., Jaki, T., Mander, A., Evans, T. R. J., Lee, S., Hopewell, S., Rantell, K. R., Chan, A.-W., Bedding, A., Stephens, R., Richards, D., Roberts, L., Kirkpatrick, J., de Bono, J., Yap, C. (2023) Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study. BMC Medicine, 21, (doi: 10.1186/s12916-023-02937-0)

Whyte, D., Skalka, G., Walsh, P., Wilczynska, A., Paul, N. R., Mitchel, C., Nixon, C., Clarke, W., Bushell, M., Morton, J. P., Murphy, D. J., Muthalagu, N. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, 17, pp. 1212-1227. (doi: 10.1002/1878-0261.13425)

Farahmand, P., Gyuraszova, K., Rooney, C., Raffo-Iraolagoitia, X. L., Jayasekera, G., Hedley, A., Johnson, E., Chernova, T., Malviya, G., Hall, H., Monteverde, T., Blyth, K., Duffin, R., Carlin, L. M., Lewis, D., le Quesne, J., MacFarlane, M., Murphy, D. J. (2023) Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Frontiers in Toxicology, 5, (doi: 10.3389/ftox.2023.1200650)

Pennel, K., Morrow, E., Hatthakarnkul, P., Leslie, H., Mallon, E., Andersen, D., Jamieson, N., McMillan, D., Roseweir, A., Edwards, J. (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12, pp. 13225-13240. (doi: 10.1002/cam4.6014)

Hamid, O., Hassel, J. C., Shoushtari, A. N., Meier, F., Bauer, T. M., Salama, A. K.S., Kirkwood, J. M., Ascierto, P. A., Lorigan, P. C., Mauch, C., Orloff, M., Evans, T. R. J., Holland, C., Edukulla, R., Abedin, S. E., Middleton, M. R. (2023) Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study. Journal for ImmunoTherapy of Cancer, 11, (doi: 10.1136/jitc-2023-006747)

Sykes, R. A., Neves, K. B., Alves-Lopes, R., Caputo, I., Jamieson, N. B., Kamdar, A., Legrini, A., Leslie, H., McIntosh, A., McConnachie, A., Morrow, A., McFarlane, R. W., Mangion, K., McAbney, J., Montezano, A. C., Touyz, R. M., Wood, C., Berry, C. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9, pp. 371-386. (doi: 10.1093/ehjcvp/pvad025)

McGovern, J., Leadbitter, S., Miller, G., Hounat, A., Kamande, I., Dolan, R. D., Horgan, P. G., Chang, D. K., Jamieson, N. B., McMillan, D. C. (2023) The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer. Scientific Reports, 13, (doi: 10.1038/s41598-023-35396-x)

May, S., Muller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Voorde, J. V., Officer-Jones, L., Ballantyne, F., Powley, I. R., Drake, T. M., Kiourtis, C., Keith, A., Rocha, A. S., Tardito, S., Sumpton, D., Le Quesne, J., Bushell, M., Sansom, O. J., Bird, T. G. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78, pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009)

Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30, pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w)

Conway, J. R. W. et al. (2023) Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse. Science Advances, 9, (doi: 10.1126/sciadv.adf9063)

Wood, C. S., Pennel, K. A.F., Leslie, H., Legrini, A., Cameron, A. J., Melissourgou-Syka, L., Quinn, J. A., van Wyk, H. C., Hay, J., Roseweir, A. K., Nixon, C., Roxburgh, C. S.D., McMillan, D. C., Biankin, A. V., Sansom, O. J., Horgan, P. G., Edwards, J., Steele, C. W., Jamieson, N. B. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83, pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794)

Tempero, M. A. et al. (2023) Adjuvant nab-paclitaxel + gemcitabine in resected pancreatic ductal adenocarcinoma: results from a randomized, open-label, phase III trial. Journal of Clinical Oncology, 41, pp. 2007-2019. (doi: 10.1200/JCO.22.01134)

Chung, T., Garcia, L., Swamynathan, M. M., Froeling, F. E.M., Trotman, L. C., Tuveson, D. A., Lyons, S. K. (2023) Internally controlled and dynamic optical measures of functional tumor biology. Analytical Chemistry, 95, pp. 5661-5670. (doi: 10.1021/acs.analchem.2c05450)

Paiella, S., Azzolina, D., Gregori, D., Malleo, G., Golan, T., Simeone, D.M., Davis, M.B., Vacca, P.G., Crovetto, A., Bassi, C., Salvia, R., Biankin, A.V., Casolino, R. (2023) A systematic review and meta-analysis of germline BRCA mutations in pancreatic cancer patients identifies global and racial disparities in access to genetic testing. ESMO Open, 8, (doi: 10.1016/j.esmoop.2023.100881)

Barry, S. T., Gabrilovich, D. I., Sansom, O. J., Campbell, A. D., Morton, J. P. (2023) Therapeutic targeting of tumour myeloid cells. Nature Reviews Cancer, 23, pp. 216-237. (doi: 10.1038/s41568-022-00546-2)

Amirkhah, R., Gilroy, K., Malla, S. B., Lannagan, T. R.M., Byrne, R. M., Fisher, N. C., Corry, S. M., Mohamed, N.-E., Naderi-Meshkin, H., Mills, M. L., Campbell, A. D., Ridgway, R. A., Ahmaderaghi, B., Murray, R., Llergo, A. B., Sanz-Pamplona, R., Villanueva, A., Batlle, E., Salazar, R., Lawler, M., Sansom, O. J., Dunne, P. D. (2023) MmCMS: mouse models' consensus molecular subtypes of colorectal cancer. British Journal of Cancer, 128, pp. 1333-1343. (doi: 10.1038/s41416-023-02157-6)

Canel, M., Sławińska, A. D., Lonergan, D. W., Kallor, A. A., Upstill-Goddard, R., Davidson, C., von Kriegsheim, A., Biankin, A. V., Byron, A., Alfaro, J., Serrels, A. (2023) FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer. Gut, (doi: 10.1136/gutjnl-2022-327927)

Coffelt, S. B., Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4, pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Debnath, J., Gammoh, N., Ryan, K. M. (2023) Autophagy and autophagy-related pathways in cancer. Nature Reviews Molecular Cell Biology, (doi: 10.1038/s41580-023-00585-z)

Ryan, K. M. (2023) Data sharing and management in 21st century cancer research. Molecular Oncology, 17, pp. 379-533. (doi: 10.1002/1878-0261.13385)

Villar, V. H., Allega, M. F., Deshmukh, R., Ackermann, T., Nakasone, M. A., Vande Voorde, J., Drake, T. M., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E. H., Vereecke, L., Jans, M., Blancke, G., Murphy, D. J., Huang, D. T., Lewis, D. Y., Bird, T. G., Sansom, O. J., Blyth, K., Sumpton, D., Tardito, S. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19, pp. 292-300. (doi: 10.1038/s41589-022-01154-9)

Marchi, S., Guilbaud, E., Tait, S. W.G., Yamazaki, T., Galluzzi, L. (2023) Mitochondrial control of inflammation. Nature Reviews Immunology, 23, pp. 159-173. (doi: 10.1038/s41577-022-00760-x)

Espinasse, A., Solovyeva, O., Dimairo, M., Weir, C., Jaki, T., Mander, A., Kightley, A., Evans, J., Lee, S., Bedding, A., Hopewell, S., Rantell, K., Liu, R., Chan, A.-W., De Bono, J., Yap, C. (2023) SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol. BMJ Open, 13, (doi: 10.1136/bmjopen-2022-068173)

Schmidt, T., Dąbrowska, A., Waldron, J. A., Hodge, K., Koulouras, G., Gabrielsen, M., Munro, J., Tack, D. C., Harris, G., McGhee, E., Scott, D., Carlin, L. M., Huang, D., Le Quesne, J., Zanivan, S., Wilczynska, A., Bushell, M. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51, pp. 1859-1879. (doi: 10.1093/nar/gkad030)

Chen, F., Gurler, S. B., Novo, D., Selli, C., Alferez, D. G., Eroglu, S., Pavlou, K., Zhang, J., Sims, A. H., Humphreys, N. E., Adamson, A., Campbell, A., Sansom, O. J., Tournier, C., Clarke, R. B., Brennan, K., Streuli, C. H., Ucar, A. (2023) RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene, 42, pp. 679-692. (doi: 10.1038/s41388-022-02574-6)

Coetzee, A. S., Carter, E. P., Rodríguez-Fernández, L., Heward, J., Wang, Q., Karim, S. A., Boughetane, L., Milton, C., Uyulur, F., Morton, J. P., Kocher, H. M., Grose, R. P. (2023) Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1. Oncogene, 42, pp. 419-500. (doi: 10.1038/s41388-022-02513-5)

Nössing, C., Ryan, K. M. (2023) 50 years on and still very much alive: ‘apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics’ British Journal of Cancer, 128, pp. 426-431. (doi: 10.1038/s41416-022-02020-0)

Casolino, R., Johns, A. L., Courtot, M., Lawlor, R. T., De Lorenzo, F., Horgan, D., Mateo, J., Normanno, N., Rubin, M., Stein, L., Subbiah, V., Westphalen, B. C., Lawler, M., Park, K., Perdomo, S., Yoshino, T., Wu, J., Biankin, A. V. (2023) Accelerating cancer omics and precision oncology in health care and research: a Lancet Oncology Commission. Lancet Oncology, 24, pp. 123-125. (doi: 10.1016/S1470-2045(23)00007-4)

Heilig, R., Lee, J., Tait, S. W.G. (2023) Mitochondrial DNA in cell death and inflammation. Biochemical Society Transactions, 51, pp. 457-472. (doi: 10.1042/BST20221525)

Dreyer, S. B., Rae, S., Bisset, K., Upstill-Goddard, R., Gemenetzis, G., Johns, A. L., Australian Pancreatic Cancer Genome Initiative3,, , Glasgow Precision Oncology Laboratory1, , Dickson, E. J., Mittal, A., Gill, A. J., Duthie, F., pea, A., Lawlor, R. T., Scarpa, A., Salvia, R., Pulvirenti, A., Zerbi, A., Marchesi, F., McKay, C. J., Biankin, A. V., Samra, J. S., Chang, D. K., Jamieson, N. B. (2023) The impact of molecular subtyping on pathological staging of pancreatic cancer. Annals of Surgery, 277, pp. e396-e405. (doi: 10.1097/SLA.0000000000005050)

Koessinger, D., Novo, D., Koessinger, A., Campos, A., Peters, J., Dutton, L., Paschke, P., Zerbst, D., Moore, M., Mitchell, L., Neilson, M., Stevenson, K., Chalmers, A., Tait, S., Birch, J., Norman, J. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5, (doi: 10.1093/noajnl/vdad067)

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9, (doi: 10.1126/sciadv.abq1858)

Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, (doi: 10.1038/s41467-022-35134-3)

Corry, S. M. et al. (2022) Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71, pp. 2502-2517. (doi: 10.1136/gutjnl-2021-326183)

Ho, G.-Y. et al. (2022) Epithelial-to-mesenchymal transition supports ovarian carcinosarcoma tumorigenesis and confers sensitivity to microtubule-targeting with eribulin. Cancer Research, 82, pp. 4457-4473. (doi: 10.1158/0008-5472.can-21-4012)

Knight, J. R.P., Proud, C. G., Mallucci, G., von der Haar, T., Smales, C. M., Willis, A. E., Sansom, O. J. (2022) Eukaryotic elongation factor 2 kinase activity is required for the phenotypes of the Rpl24Bst mouse. Journal of Investigative Dermatology, 142, pp. 3346-3348.e1. (doi: 10.1016/j.jid.2022.06.019)

van Wagensveld, L., van Baal, J. O. A. M., Timmermans, M., Gaillard, D., Borghuis, L., Coffelt, S. B., Rosenberg, E. H., Lok, C. A. R., Nijman, H. W., Kooreman, L. F. S., Sanders, J., de Bruijn, M., Wessels, L. F. A., van der Wiel, R., Rausch, C., Broeks, A., Kruitwagen, R. F. P. M., van der Aa, M. A., Sonke, G. S., Schouten, P. C., Van de Vijver, K. K., Horlings, H. M. (2022) Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer. Cancers, 14, (doi: 10.3390/cancers14235965)

Ali, A., Jamieson, N. B., Khan, I. Q., Chang, D., Giovannetti, E., Funel, N., Frampton, A.E., Morton, J., Sansom, O., Evans, T.R.J., Duthie, F., McKay, C. J., Samra, J.S., Gill, A. J., Biankin, A., Oien, K. A. (2022) Prognostic implications of microRNA-21 overexpression in pancreatic ductal adenocarcinoma: an international multicenter study of 686 patients. American Journal of Cancer Research, 12, pp. 5668-5683.

Smith, C. D.L., McMahon, A. D., Ross, A., Inman, G. J., Conway, D. I. (2022) Risk prediction models for head and neck cancer: a rapid review. Laryngoscope Investigative Otolaryngology, 7, pp. 1893-1908. (doi: 10.1002/lio2.982)

Ramadan, R., Wouters, V. M., van Neerven, S. M., de Groot, N. E., Martins, G. T., Muncan, V., Franklin, O. D., Battle, M., Carlson, K. S., Leach, J., Sansom, O. J., Boulard, O., Chamaillard, M., Vermeulen, L., Medema, J. P., Huels, D. J. (2022) The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biology Open, 11, (doi: 10.1242/bio.059544)

Evans, J., Keith, N., Paul, J. (2022) An analysis of Relative Telomere Length (RTL) during peri-operative chemotherapy in patients with operable gastric or gastro-oesophageal junction adenocarcinoma. (doi: 10.17504/protocols.io.ca5csg2w)

McEwan, D. G., Ryan, K. M. (2022) ATG2 and VPS13 proteins: Molecular highways transporting lipids to drive membrane expansion and organelle communication. FEBS Journal, 289, pp. 7113-7127. (doi: 10.1111/febs.16280)

Pennel, K. A. F., Quinn, J. A., Nixon, C., Inthagard, J., van Wyk, H. C., Chang, D., Rebus, S., GPOL Group, , Hay, J., Maka, N. N., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C., Park, J. H., Roseweir, A. K., Steele, C. W., Edwards, J. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8, pp. 509-520. (doi: 10.1002/cjp2.290)

Bellomo, G., Rainer, C., Quaranta, V., Astuti, Y., Raymant, M., Boyd, E., Stafferton, R., Campbell, F., Ghaneh, P., Halloran, C. M., Hammond, D. E., Morton, J. P., Palmer, D., Vimalachandran, D., Jones, R., Mielgo, A., Schmid, M. C. (2022) Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. Gut, 71, pp. 2284-2299. (doi: 10.1136/gutjnl-2021-325272)

Bryce, A. S., Dreyer, S. B., Froeling, F. E.M., Chang, D. K. (2022) Exploring the biology of cancer-associated fibroblasts in pancreatic cancer. Cancers, 14, (doi: 10.3390/cancers14215302)

Hedayioglu, F., Mead, E. J., O‘Connor, P. B.F., Skiotys, M., Sansom, O. J., Mallucci, G. R., Willis, A. E., Baranov, P. V., Smales, C. M., von der Haar, T. (2022) Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles. Nucleic Acids Research, 50, (doi: 10.1093/nar/gkac705)

Edwards, S. C., Hedley, A., Hoevenaar, W. H.M., Wiesheu, R., Glauner, T., Kilbey, A., Shaw, R., Boufea, K., Batada, N., Hatano, S., Yoshikai, Y., Blyth, K., Miller, C., Kirschner, K., Coffelt, S. B. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220, (doi: 10.1084/jem.20211431)

Vringer, E., Tait, S. W.G. (2022) Mitochondria and cell death-associated inflammation. Cell Death and Differentiation, 30, pp. 304-312. (doi: 10.1038/s41418-022-01094-w)

Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71, pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259)

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29, pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3)

May, S., Greenow, K. R., Higgins, A. T., Derrick, A. V., Taylor, E., Pan, P., Konstantinou, M., Nixon, C., Wooley, T. E., Sansom, O. J., Wang, L.-S., Parry, L. (2022) Modification of diet to reduce the stemness and tumorigenicity of murine and human intestinal cells. Molecular Nutrition and Food Research, 66, (doi: 10.1002/mnfr.202200234)

Flanagan, D. J., Woodcock, S. A., Phillips, C., Eagle, C., Sansom, O. J. (2022) Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition. Pharmacology and Therapeutics, 238, (doi: 10.1016/j.pharmthera.2022.108179)

Fisher, N. C. et al. (2022) Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data. Clinical Cancer Research, 28, pp. 4056-4069. (doi: 10.1158/1078-0432.CCR-22-1102)

Moser, R., Annis, J., Nikolova, O., Whatcott, C. J., Gurley, K. E., Mendez, E., Moran-Jones, K., Dorrell, C., Sears, R. C., Kuo, C. J., Han, H., Biankin, A. V., Grandori, C., Von Hoff, D. D., Kemp, C. J. (2022) Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL. Cancer Research, 82, pp. 3375-3393. (doi: 10.1158/0008-5472.CAN-21-4222)

Freckmann, E. C., Sandilands, E., Cumming, E., Neilson, M., Roman-Fernandez, A., Nikolatou, K., Nacke, M., Lannagan, T. R.M., Hedley, A., Strachan, D., Salji, M., Morton, J. P., McGarry, L., Leung, H. Y., Sansom, O. J., Miller, C. J., Bryant, D. M. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, (doi: 10.1038/s41467-022-32958-x)

Kalkavan, H., Chen, M. J., Crawford, J. C., Quarato, G., Fitzgerald, P., Tait, S. W.G., Goding, C. R., Green, D. R. (2022) Sublethal cytochrome c release generates drug-tolerant persister cells. Cell, 185, pp. 3356-3374.e22. (doi: 10.1016/j.cell.2022.07.025)

Beer, P. A., Biankin, A. V. (2022) Bridging the implementation gap: delivering complex genomic analysis for routine cancer care. Annals of Oncology, 33, pp. 857-859. (doi: 10.1016/j.annonc.2022.06.015)

Ismail, N. F. B., Foth, M., Yousef, A. R. E., Cui, N., Leach, J. D.G., Jamieson, T., Karim, S. A., Salmond, J. M., Morton, J. P., Iwata, T. (2022) Loss of Cxcr2 in myeloid cells promotes tumour progression and T cell infiltration in invasive bladder cancer. Bladder Cancer, 8, pp. 277-290. (doi: 10.3233/BLC-211645)

Zeng, S., Lan, B., Ren, X., Zhang, S., Schreyer, D., Eckstein, M., Yang, H., Britzen-Laurent, N., Dahl, A., Mukhopadhyay, D., Chang, D., Kutschick, I., Pfeffer, S., Bailey, P., Biankin, A., Grützmann, R., Pilarsky, C. (2022) CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer. Journal of Experimental and Clinical Cancer Research, 41, (doi: 10.1186/s13046-022-02443-w)

Horgan, D., Borisch, B., Eliasen, B., Kapitein, P., Biankin, A. V., Gijssels, S., Zaiac, M., Fandel, M.-H., Lal, J. A., Kozaric, M., Moss, B., De Maria, R., Geanta, M., Nowak, F., Montserrat-Moliner, A., Riess, O. (2022) Meeting the need for a discussion of unmet medical need. Healthcare, 10, (doi: 10.3390/healthcare10081578)

Khan, K. S., Gall, L. S., Dreyer, S., McCollum, C., Chuntamongkol, R., Craig, C., MacKay, C., Macdonald, A., Forshaw, M. (2022) Stage migration in newly diagnosed oesophagogastric cancer during the first wave of the COVID-19 pandemic. British Journal of Surgery, 109, pp. 773-774. (doi: 10.1093/bjs/znac112)

Azkanaz, M., Corominas-Murtra, B., Ellenbroek, S. I.J., Bruens, L., Webb, A. T., Laskaris, D., Oost, K. C., Lafirenze, S. J.A., Annusver, K., Messal, H. A., Iqbal, S., Flanagan, D. J., Huels, D. J., Rojas-Rodríguez, F., Vizoso, M., Kasper, M., Sansom, O. J., Snippert, H. J., Liberali, P., Simons, B. D., Katajisto, P., Hannezo, E., van Rheenen, J. (2022) Retrograde movements determine effective stem cell numbers in the intestine. Nature, 607, pp. 548-554. (doi: 10.1038/s41586-022-04962-0)

Patel, R., Ford, C. A., Rodgers, L., Rushworth, L. K., Fleming, J., Mui, E., Zhang, T., Watson, D., Lynch, V., Mackay, G., Sumpton, D., Sansom, O. J., Vande Voorde, J., Leung, H. Y. (2022) Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression. Cancer Research, 82, pp. 2565-2575. (doi: 10.1158/0008-5472.CAN-21-1301)

Zacharioudakis, E., Agianian, B., Kumar MV, V., Biris, N., Garner, T. P., Rabinovich-Nikitin, I., Ouchida, A. T., Margulets, V., Nordstrøm, L. U., Riley, J. S., Dolgalev, I., Chen, Y., Wittig, A. J. H., Pekson, R., Mathew, C., Wei, P., Tsirigos, A., Tait, S. W.G., Kirshenbaum, L. A., Kitsis, R. N., Gavathiotis, E. (2022) Modulating mitofusins to control mitochondrial function and signaling. Nature Communications, 13, (doi: 10.1038/s41467-022-31324-1)

Barthet, V. J.A., Mrschtik, M., Kania, E., McEwan, D. G., Croft, D., O’Prey, J., Long, J. S., Ryan, K. M. (2022) DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions. FEBS Journal, 289, pp. 3752-3769. (doi: 10.1111/febs.16365)

Casolino, R., Corbo, V., Beer, P., Hwang, C.-I., Paiella, S., Silvestri, V., Ottini, L., Biankin, A. V. (2022) Germline aberrations in pancreatic cancer: implications for clinical care. Cancers, 14, (doi: 10.3390/cancers14133239)

Vaziri-Gohar, A. et al. (2022) Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors. Nature Cancer, 3, pp. 852-865. (doi: 10.1038/s43018-022-00393-y)

Sala, A., Cameron, J. M., Jenkins, C. A., Barr, H., Christie, L., Conn, J. J.A., Evans, T. R. J., Harris, D. A., Palmer, D. S., Rinaldi, C., Theakstone, A. G., Baker, M. J. (2022) Liquid biopsy for pancreatic cancer detection using infrared spectroscopy. Cancers, 14, (doi: 10.3390/cancers14133048)

Ahmed, A., Giampazolias, E., Patel, R., Leung, H., Tait, S. W.G. (2022) Caspase-independent cell death as a novel therapy for advanced prostate cancer.

Evans, J., Keith, N., Paul, J. (2022) An analysis of Relative Telomere Length (RTL) during chemotherapy in patients with advanced gastro-oesophageal adenocarcinoma. (doi: 10.17504/protocols.io.n92ldznenv5b/v1)

Patel, M., Pennel, K. A.F., Quinn, J. A., Hood, H., Chang, D. K., Biankin, A. V., Rebus, S., Roseweir, A. K., Park, J. H., Horgan, P. G., McMillan, D. C., Edwards, J. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126, pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4, pp. 693-710. (doi: 10.1038/s42255-022-00582-0)

CHOLECOVID Collaborative, (2022) Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study) BJS Open, 6, (doi: 10.1093/bjsopen/zrac052)

Ryan, K. M. (2022) Navigating the current landscape of scientific publishing – the Molecular Oncology perspective. Molecular Oncology, 16, pp. 2297-2299. (doi: 10.1002/1878-0261.13271)

Cao, K., Riley, J. S., Heilig, R., Montes-Gómez, A. E., Vringer, E., Berthenet, K., Cloix, C., Elmasry, Y., Spiller, D. G., Ichim, G., Campbell, K. J., Gilmore, A. P., Tait, S. W.G. (2022) Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Developmental Cell, 57, pp. 1211-1225.e6. (doi: 10.1016/j.devcel.2022.03.019)

Tait, S. W.G. (2022) Killing cells using light (activated) sabers. Journal of Cell Biology, 221, (doi: 10.1083/jcb.202205018)

Kidger, A. M., Saville, M. K., Rushworth, L. K., Davidson, J., Stellzig, J., Ono, M., Kuebelsbeck, L. A., Janssen, K.-P., Holzmann, B., Morton, J. P., Sansom, O. J., Caunt, C. J., Keyse, S. M. (2022) Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene, 41, pp. 2811-2823. (doi: 10.1038/s41388-022-02302-0)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Izquierdo-Sanchez, L. et al. (2022) Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry. Journal of Hepatology, 76, pp. 1109-1121. (doi: 10.1016/j.jhep.2021.12.010)

Lawrence, M., Wiesheu, R., Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, (doi: 10.1016/j.biocel.2022.106213)

Fanfone, D., Wu, Z., Mammi, J., Berthenet, K., Neves, D., Weber, K., Halaburkova, A., Virard, F., Bunel, F., Jamard, C., Hernandez-Vargas, H., Tait, S. W.G., Hennino, A., Ichim, G. (2022) Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. eLife, 11, (doi: 10.7554/eLife.73150)

Glen, C., Tan, Y. Y., Waterston, A., Evans, T. R. J., Jones, R. J., Petrie, M. C., Lang, N. N. (2022) Mechanistic and clinical overview cardiovascular toxicity of BRAF and MEK inhibitors: JACC: CardioOncology state-of-the-art review. JACC: CardioOncology, 4, pp. 1-18. (doi: 10.1016/j.jaccao.2022.01.096)

Walter, R. J., Sonnentag, S. J., Munoz-Sagredo, L., Merkel, M., Richert, L., Bunert, F., Heneka, Y. M., Loustau, T., Hodder, M., Ridgway, R. A., Sansom, O. J., Mely, Y., Rothbauer, U., Schmitt, M., Orian-Rousseau, V. (2022) Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop. Cell Death and Disease, 13, (doi: 10.1038/s41419-022-04607-0)

Humpton, T. J., Hock, A. K., Kiourtis, C., De Donatis, M., Fercoq, F., Nixon, C., Bryson, S., Strathdee, D., Carlin, L. M., Bird, T. G., Blyth, K., Vousden, K. (2022) A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo. Science Signaling, 15, (doi: 10.1126/scisignal.abd9099)

Strittmatter, N. et al. (2022) Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging. Analytical Chemistry, 94, pp. 1795-1803. (doi: 10.1021/acs.analchem.1c04579)

Dreyer, S. B., Upstill-Goddard, R., Legrini, A., Biankin, A. V., Jamieson, N. B., Chang, D. K. (2022) Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence. Gastroenterology, 162, pp. 320-324.e4. (doi: 10.1053/j.gastro.2021.09.022)

Paterson, K., Paterson, S., Mulholland, T., Coffelt, S.B., Zagnoni, M. (2022) Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy. IEEE Open Journal of Engineering in Medicine and Biology, 3, pp. 86-95. (doi: 10.1109/OJEMB.2022.3178302)

Dreyer, S., Upstill-Goddard, R., Legrini, A., Biankin, A., Jamieson, N., Chang, D. (2022) Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence. (doi: 10.1016/j.hpb.2022.05.086)

Curio, S., Edwards, S. C., Suzuki, T., McGovern, J., Triulzi, C., Yoshida, N., Jonsson, G., Glauner, T., Rami, D., Wiesheu, R., Kilbey, A., Purcell, R. V., Coffelt, S. B., Guerra, N. (2022) NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1, (doi: 10.1093/discim/kyac002)

Gemenetzis, G., McKay, S., Pathak, S., Moir, J., Laing, R., Jamieson, N. B., Young, A. L., Chatzizacharias, N. A., Giovinazzo, F., Roberts, K. J. (2021) Surgical management of non-metastatic pancreatic cancer in the United Kingdom: results of a nationwide survey on current practice. Frontiers in Oncology, 11, (doi: 10.3389/fonc.2021.791946)

Knight, J. R.P., Vlahov, N., Gay, D. M., Ridgway, R. A., Faller, W. J., Proud, C., Mallucci, G. R., von der Haar, T., Smales, C. M., Willis, A. E., Sansom, O. J. (2021) Rpl24 Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K. eLife, 10, (doi: 10.7554/elife.69729)

Rabas, N., Palmer, S., Mitchell, L., Ismail, S., Gohlke, A., Riley, J. S., Tait, S. W.G., Gammage, P., Lemgruber Soares, L., MacPherson, I. R., Norman, J. C. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220, (doi: 10.1083/jcb.202006049)

Falcomata, C. et al. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. Cancer Discovery, 11, pp. 3158-3177. (doi: 10.1158/2159-8290.CD-21-0209)

Johnson, S. A., Ormsby, M. J., Wessel, H., Hulme, H., Bravo-Blas, A., McIntosh, A., Mason, S., Coffelt, S., Tait, S. W.G., Mcl. Mowat, A., Milling, S., Blyth, K., Wall, D. M. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51, pp. 3228-3238. (doi: 10.1002/eji.202048913)

Pulvirenti, A. et al. (2021) Multi-institutional development and external validation of a nomogram to predict recurrence after curative resection of pancreatic neuroendocrine tumors. Annals of Surgery, 274, pp. 1051-1057. (doi: 10.1097/SLA.0000000000003579)

McCowan, J., Fercoq, F., Kirkwood, P. M., T’Jonck, W., Hegarty, L. M., Mawer, C. M., Cunningham, R., Mirchandani, A. S., Hoy, A., Humphries, D. C., Jones, G.-R., Hansen, C. G., Hirani, N., Jenkins, S. J., Henri, S., Malissen, B., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K., Carlin, L. M., Bain, C. C. (2021) The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair. Science Immunology, 6, (doi: 10.1126/sciimmunol.abj2132)

Hollis, R. L., Stillie, L. J., Hopkins, S., Bartos, C., Churchman, M., Rye, T., Nussey, F., Fegan, S., Nirsimloo, R., Inman, G. J., Herrington, C. S., Gourley, C. (2021) Clinicopathological determinants of recurrence risk and survival in mucinous ovarian carcinoma. Cancers, 13, (doi: 10.3390/cancers13225839)

Carotenuto, P. et al. (2021) Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage. Nature Communications, 12, (doi: 10.1038/s41467-021-27099-6)

Heino, S., Fang, S., Lähde, M., Högström, J., Nassiri, S., Campbell, A., Flanagan, D., Raven, A., Hodder, M., Nasreddin, N., Xue, H.-H., Delorenzi, M., Leedham, S., Petrova, T. V., Sansom, O., Alitalo, K. (2021) Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science Advances, 7, (doi: 10.1126/sciadv.abj0512)

Bock, F. J., Sedov, E., Koren, E., Koessinger, A. L., Cloix, C., Zerbst, D., Athineos, D., Anand, J., Campbell, K. J., Blyth, K., Fuchs, Y., Tait, S. W.G. (2021) Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death. Nature Communications, 12, (doi: 10.1038/s41467-021-26613-0)

O'Connor, M. N., Kallenberg, D. M., Camilli, C., Pilotti, C., Dritsoula, A., Jackstadt, R., Bowers, C. E., Watson, H. A., Alatsatianos, M., Ohme, J., Dowsett, L., George, J., Blackburn, J. W.D., Wang, X., Singhal, M., Augustin, H. G., Ager, A., Sansom, O. J., Moss, S. E., Greenwood, J. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2, pp. 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002)

McKay, S. C. et al. (2021) Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience. HPB, 23, pp. 1656-1665. (doi: 10.1016/j.hpb.2021.03.003)

Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)

Klionsky, D. J. et al. (2021) Autophagy in major human diseases. EMBO Journal, 40, (doi: 10.15252/embj.2021108863)

Murphy, K. J. et al. (2021) Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Science Advances, 7, (doi: 10.1126/sciadv.abh0363)

Lampis, A., Hahne, J. C., Gasparini, P., Cascione, L., Hedayat, S., Vlachogiannis, G., Murgia, C., Fontana, E., Edwards, J., Horgan, P. G., Terracciano, L., Sansom, O. J., Martins, C. D., Kramer-Marek, G., Croce, C. M., Braconi, C., Fassan, M., Valeri, N. (2021) MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer. Cell Death and Differentiation, 28, pp. 2970-2982. (doi: 10.1038/s41418-021-00820-0)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16, pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018)

Campbell, K. J., Mason, S. M., Winder, M. L., Willemsen, R. B.E., Cloix, C., Lawson, H., Rooney, N., Dhayade, S., Sims, A. H., Blyth, K., Tait, S. W.G. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28, pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4)

Halle-Smith, J. M., Hall, L., Daamen, L. A., Hodson, J., Pande, R., Young, A., Jamieson, N. B., Lamarca, A., van Santvoort, H. C., Quintus Molenaar, I., Valle, J. W., Roberts, K. J. (2021) Clinical benefit of surveillance after resection of pancreatic ductal adenocarcinoma: A systematic review and meta-analysis. European Journal of Surgical Oncology, 47, pp. 2248-2255. (doi: 10.1016/j.ejso.2021.04.031)

Finn, R. S., Kudo, M., Cheng, A.-L., Wyrwicz, L., Ngan, R. K.C., Blanc, J.-F., Baron, A. D., Vogel, A., Ikeda, M., Piscaglia, F., Han, K.-H., Qin, S., Minoshima, Y., Kanekiyo, M., Ren, M., Dairiki, R., Tamai, T., Dutcus, C. E., Ikezawa, H., Funahashi, Y., Evans, T. R. J. (2021) Pharmacodynamic biomarkers predictive of survival benefit with lenvatinib in unresectable hepatocellular carcinoma: from the phase III REFLECT study. Clinical Cancer Research, 27, pp. 4848-4858. (doi: 10.1158/1078-0432.CCR-20-4219)

Middleton, M. R., Dean, E., Evans, T. R.J., Shapiro, G. I., Pollard, J., Hendriks, B. S., Falk, M., Diaz-Padilla, I., Plummer, R. (2021) Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours. British Journal of Cancer, 125, pp. 510-519. (doi: 10.1038/s41416-021-01405-x)

Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, (doi: 10.1038/s41467-021-25173-7)

Casolino, R., Paiella, S., Azzolina, D., Beer, P. A., Corbo, V., Lorenzoni, G., Gregori, D., GOlan, T., Braconi, C., Froeling, F. E.M., Milella, M., Scarpa, A., Pea, A., Malleo, G., Salvia, R., Bassi, C., Chang, D. K., Biankin, A. V. (2021) Homologous recombination deficiency in pancreatic cancer: a systematic review and prevalence meta-analysis. Journal of Clinical Oncology, 39, pp. 2617-2631. (doi: 10.1200/JCO.20.03238)

Schwappacher, R., Dieterich, W., Reljic, D., Pilarsky, C., Mukhopadhyay, D., Chang, D. K., Biankin, A. V., Siebler, J., Herrmann, H. J., Neurath, M. F., Zopf, Y. (2021) Muscle-derived cytokines reduce growth, viability and migratory activity of pancreatic cancer cells. Cancers, 13, (doi: 10.3390/cancers13153820)

Vivekanandhan, S., Madamsetty, V. S., Angom, R. S., Dutta, S. K., Wang, E., Caulfield, T., Pletnev, A. A., Upstill-Goddard, R., Asmann, Y. W., Chang, D., Spaller, M. R., Mukhopadhyay, D. (2021) Role of PLEXIND1/TGFβ signaling axis in pancreatic ductal adenocarcinoma progression correlates with the mutational status of KRAS. Cancers, 13, (doi: 10.3390/cancers13164048)

Lei, M., Siemers, N. O., Pandya, D., Chang, H., Sanchez, T., Harbison, C., Szabo, P. M., Janjigian, Y., Ott, P. A., Sharma, P., Bendell, J., Evans, T. R. J., de Braud, F., Chau, I., Boyd1, Z. (2021) Analyses of PD-L1 and inflammatory gene expression association with efficacy of nivolumab±Ipilimumab in gastric cancer/gastroesophageal junction cancer. Clinical Cancer Research, 27, pp. 3926-3935. (doi: 10.1158/1078-0432.CCR-20-2790)

Ntala, C., Salji, M., Salmond, J., Officer, L., Teodosio, A. V., Blomme, A., McGhee, E. J., Powley, I., Ahmad, I., Kruithof-de Julio, M., Thalmann, G., Roberts, E., Goodyear, C. S., Jamaspishvili, T., Berman, D. M., Carlin, L. M., Le Quesne, J., Leung, H. Y. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001)

Haq, M. I., Drake, T. M., Goh, T. L., Ahmed, A., Forrest, E., Barclay, S., Gillespie, R., Priest, M., Evans, J., Graham, J., Ballantyne, S., McMillan, D. C., Hayes, P. C., Bird, T. G., Stanley, A. J. (2021) Effect of hepatocellular carcinoma surveillance programmes on overall survival in a mixed cirrhotic UK population: a prospective, longitudinal cohort study. Journal of Clinical Medicine, 10, (doi: 10.3390/jcm10132770)

Welisch, G., Twelves, C., Plummer, R., Evans, J., Danson, S., Symeonides, S., Halsey, C., Jones, R., Hanna, C., Gallagher, P., Walls, G., Taylor, K., Barnett, S., Forde, C., White, M., Williams, C., El Badri, S., Chipole, B.'e. D., Keith, N. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? (doi: 10.17605/OSF.IO/KWHQF)

Fercoq, F., Carlin, L. M. (2021) “Mind the GAP”: RGS1 hinders antitumor lymphocytes. Nature Immunology, 22, pp. 802-804. (doi: 10.1038/s41590-021-00961-x)

Paterson, K., Zanivan, S., Glasspool, R., Coffelt, S.B., Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21, pp. 2306-2329. (doi: 10.1039/D0LC01305F)

Nászai, M., Bellec, K., Yu, Y., Román-Fernández, Á., Sandilands, E., Johansson, J., Campbell, A. D., Norman, J. C., Sansom, O. J., Bryant, D. M., Cordero, J. B. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, (doi: 10.7554/eLife.63807)

Flanagan, D. J. et al. (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature, 594, pp. 430-435. (doi: 10.1038/s41586-021-03525-z)

Koessinger, A. L., Koessinger, D., Kinch, K., Martínez-Escardó, L., Paul, N. R., Elmasry, Y., Malviya, G., Cloix, C., Campbell, K. J., Bock, F. J., O'Prey, J., Stevenson, K., Nixon, C., Jackson, M. R., Ichim, G., Stewart, W., Blyth, K., Ryan, K. M., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)

Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, (doi: 10.1038/s41467-021-23717-5)

Nielsen, S. R., Strøbech, J. E., Horton, E. R., Jackstadt, R., Laitala, A., Bravo, M. C., Maltese, G., Jensen, A. R. D., Reuten, R., Rafaeva, M., Karim, S. A., Hwang, C.-I., Arnes, L., Tuveson, D. A., Sansom, O. J., Morton, J. P., Erler, J. T. (2021) Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature Communications, 12, (doi: 10.1038/s41467-021-23731-7)

Barthet, V. J.A., Brucoli, M., Ladds, M. J.G.W., Nössing, C., Kiourtis, C., Baudot, A. D., O'Prey, J., Zunino, B., Müller, M., May, S., Nixon, C., Long, J. S., Bird, T. G., Ryan, K. M. (2021) Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Science Advances, 7, (doi: 10.1126/sciadv.abf9141)

Ewing, A. et al. (2021) Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma. Clinical Cancer Research, 27, pp. 3201-3214. (doi: 10.1158/1078-0432.CCR-20-4068)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11, pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652)

Gudiño, V., Pohl, S. Ö.-G., Billard, C. V., Cammareri, P., Bolado, A., Aitken, S., Stevenson, D., Hall, A. E., Agostino, M., Cassidy, J., Nixon, C., Von Kriegsheim, A., Freile, P., Popplewell, L., Dickson, G., Murphy, L., Wheeler, A., Dunlop, M., Din, F., Strathdee, D., Sansom, O. J., Myant, K. B. (2021) RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nature Communications, 12, (doi: 10.1038/s41467-021-22531-3)

Juzenaite, G., Secklehner, J., Vuononvirta, J., Helbawi, Y., Mackey, J., Dean, C., Harker, J. A., Carlin, L. M., Rankin, S., De Filippo, K. (2021) Lung marginated and splenic murine resident neutrophils constitute pioneers in tissue-defense during systemic E. coli challenge. Frontiers in Immunology, 12, (doi: 10.3389/fimmu.2021.597595)

Galbraith, L. C.A., Mui, E., Nixon, C., Hedley, A., Strachan, D., MacKay, G., Sumpton, D., Sansom, O. J., Leung, H. Y., Ahmad, I. (2021) PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene, 40, pp. 2355-2366. (doi: 10.1038/s41388-021-01707-7)

McNamara, M. G., Bridgewater, J., Palmer, D.H., Faluyi, O., Wasan, H., Patel, A., Ryder, W.D., Barber, S., Gnanaranjan, C., Ghazaly, E., Evans, T.R.J., Valle, J.W. (2021) A phase Ib study of NUC-1031 in combination with cisplatin for the first-line treatment of patients with advanced biliary tract cancer (ABC-08) Oncologist, 26, pp. e669-e678. (doi: 10.1002/onco.13598)

Rosenfeldt, M. T., O’Prey, J., Lindsay, C. R., Nixon, C., Roth, S., Sansom, O. J., Ryan, K. (2021) Loss of autophagy affects melanoma development in a manner dependent on PTEN status. Cell Death and Differentiation, 28, pp. 1437-1439. (doi: 10.1038/s41418-021-00746-7)

Roca-Portoles, A., Tait, S. W.G. (2021) Mitochondrial quality control: from molecule to organelle. Cellular and Molecular Life Sciences, 78, pp. 3853-3866. (doi: 10.1007/s00018-021-03775-0)

van der Weyden, L., Harle, V., Turner, G., Offord, V., Iyer, V., Droop, A., Swiatkowska, A., Rabbie, R., Campbell, A. D., Sansom, O. J., Pardo, M., Choudhary, J. S., Ferreira, I., Tullett, M., Arends, M. J., Speak, A. O., Adams, D. J. (2021) CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Communications Biology, 4, (doi: 10.1038/s42003-021-01912-w)

McFarlane, A. J., Fercoq, F., Coffelt, S. B., Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131, (doi: 10.1172/JCI143759)

Nacke, M., Sandilands, E., Nikolatou, K., Román-Fernández, Á., Mason, S., Patel, R., Lilla, S., Yelland, T., Galbraith, L. C.A., Freckmann, E. C., McGarry, L., Morton, J. P., Shanks, E., Leung, H. Y., Markert, E., Ismail, S., Zanivan, S., Blyth, K., Bryant, D. M. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, (doi: 10.1038/s41467-021-21847-4)

Annese, V. F., Patil, S. B., Hu, C., Giagkoulovits, C., Al-Rawhani, M. A., Grant, J., Macleod, M., Clayton, D.J., Heaney, L.M., Daly, R., Accarino, C., Shah, Y. D., Cheah, B. C., Beeley, J., Evans, T.R.J., Jones, R., Barrett, M. P., Cumming, D. R.S. (2021) A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems and Nanoengineering, 7, (doi: 10.1038/s41378-021-00243-4)

Sphyris, N., Hodder, M. C., Sansom, O. J. (2021) Subversion of niche-signalling pathways in colorectal cancer: what makes and breaks the intestinal stem cell. Cancers, 13, (doi: 10.3390/cancers13051000)

Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F., Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J., Machesky, L. M. (2021) The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice. Journal of Investigative Dermatology, 141, pp. 628-637.e15. (doi: 10.1016/j.jid.2020.06.029)

Race, A. M., Sutton, D., Hamm, G., Maglennon, G., Morton, J. P., Strittmatter, N., Campbell, A., Sansom, O. J., Wang, Y., Barry, S. T., Takáts, Z., Goodwin, R. J.A., Bunch, J. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93, pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726)

Keith, N., Plummer, R., Coyle, V., Cameron, D., Evans, J., Twelves, C., Palmer, D., Danson, S., Graham, D., Welisch, G. (2021) Early Phase Cancer Research in the COVID-19 Pandemic: an ECMC North Initiative. (doi: 10.17605/OSF.IO/6WTN2)

Lakis, V. et al. (2021) DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association. Communications Biology, 4, (doi: 10.1038/s42003-020-01469-0)

Murta, T., Steven, R. T., Nikula, C. J., Thomas, S. A., Zeiger, L. B., Dexter, A., Elia, E. A., Yan, B., Campbell, A. D., Goodwin, R. J.A., Takáts, Z., Sansom, O. J., Bunch, J. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93, pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179)

Jones, C. M., Radhakrishna, G., Aitken, K., Bridgewater, J., Corrie, P., Eatock, M., Goody, R., Ghaneh, P., Good, J., Grose, D., Holyoake, D., Hunt, A., Jamieson, N. B., Palmer, D. H., Soonawalla, Z., Valle, J. W., Hawkins, M. A., Mukherjee, S. (2021) Reply to comment on “The UK consensus position on the treatment of pancreatic cancer during the COVID-19 pandemic” British Journal of Cancer, 124, pp. 679-680. (doi: 10.1038/s41416-020-01133-8)

Casolino, R., Braconi, C., Malleo, G., Paiella, S., Bassi, C., Milella, M., Dreyer, S.B., Froeling, F.E.M., Chang, D.K., Biankin, A.V., Golan, T. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32, pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013)

Tajan, M., Hennequart, M., Cheung, E. C., Zani, F., Hock, A. K., Legrave, N., Maddocks, O. D.K., Ridgway, R. A., Athineos, D., Suárez-Bonnet, A., Ludwig, R. L., Novellasdemunt, L., Angelis, N., Li, V. S.W., Vlachogiannis, G., Valeri, N., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M., Blyth, K., Sansom, O. J., Vousden, K. H. (2021) Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12, (doi: 10.1038/s41467-020-20223-y)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, (doi: 10.1038/s41467-020-20378-8)

Griffith, B. G.C., Upstill-Goddard, R., Brunton, H., Grimes, G. R., Biankin, A., Serrels, B., Byron, A., Frame, M. C. (2021) FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs. Scientific Reports, 11, (doi: 10.1038/s41598-020-80111-9)

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3)

Edwards, S. C., Hoevenaar, W. H.M., Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5)

Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, (doi: 10.1038/s41467-020-20255-4)

Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160, pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043)

Pea, A., Jamieson, N. B., Braconi, C. (2021) Biology and clinical application of regulatory RNAs in hepatocellular carcinoma. Hepatology, 73, pp. 38-48. (doi: 10.1002/hep.31225)

Al-mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Chalmers, A.J., Holmes, W.M. (2021) Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of glioblastoma. Magnetic resonance imaging, 85, pp. 121-127. (doi: 10.1016/j.mri.2021.10.030)

Lähde, M., Heino, S., Högström, J., Kaijalainen, S., Anisimov, A., Flanagan, D., Kallio, P., Leppänen, V.-M., Ristimäki, A., Ritvos, O., Wu, K., Tammela, T., Hodder, M., Sansom, O. J., Alitalo, K. (2021) Expression of R-spondin 1 in Apc^Min/+ mice suppresses growth of intestinal adenomas by altering Wnt and transforming growth factor beta signaling. Gastroenterology, 160, pp. 245-259. (doi: 10.1053/j.gastro.2020.09.011)

Brownlie, D., Doughty-Shenton, D., Soong, D. Y.H., Nixon, C., Carragher, N. O., Carlin, L. M., Kitamura, T. (2021) Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β. Journal for ImmunoTherapy of Cancer, 9, (doi: 10.1136/jitc-2020-001740)

Froeling, F. E.M., Casolino, R., Pea, A., Biankin, A. V., Chang, D. K. (2021) Molecular subtyping and precision medicine for pancreatic cancer. Journal of Clinical Medicine, 10, (doi: 10.3390/jcm10010149)

Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy, 17, pp. 1-382. (doi: 10.1080/15548627.2020.1797280)

Morton, J. P., Watt, D. M. (2021) Heterogeneity in the pancreatic cancer microenvironment – TGFβ as a master regulator? Cancers, 13, (doi: 10.3390/cancers13194984)

Torretta, S., Scagliola, A., Ricci, L., Mainini, F., Di Marco, S., Cuccovillo, I., Kajaste-Rudnitski, A., Sumpton, D., Ryan, K. M., Cardaci, S. (2020) D-mannose suppresses macrophage IL-1β production. Nature Communications, 11, (doi: 10.1038/s41467-020-20164-6)

Miller, R.E., Leary, A., Scott, C.L., Serra, V., Lord, C.J., Bowtell, D., Chang, D.K., Garsed, D.W., Jonkers, J., Ledermann, J.A., Nik-Zainal, S., Ray-Coquard, I., Shah, S.P., Matias-Guiu, X., Swisher, E.M., Yates, L.R. (2020) ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer. Annals of Oncology, 31, pp. 1606-1622. (doi: 10.1016/j.annonc.2020.08.2102)

Moekotte, A. L., Lof, S., Van Roessel, S., Fontana, M., Dreyer, S., Shablak, A., Casciani, F., Mavroeidis, V. K., Robinson, S., Khalil, K., Gradinariu, G., Mowbray, N., Al-Sarireh, B., Fusai, G. K., Roberts, K., White, S., Soonawalla, Z., Jamieson, N. B., Salvia, R., Besselink, M. G., Abu Hilal, M. (2020) Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma. Annals of Surgery, 272, pp. 1086-1093. (doi: 10.1097/SLA.0000000000003177)

Ahmed, A., Tait, S. W.G. (2020) Targeting immunogenic cell death in cancer. Molecular Oncology, 14, pp. 2994-3006. (doi: 10.1002/1878-0261.12851)

Coffelt, S. B., Kabelitz, D., Silva-Santos, B., Kuball, J., Born, W., Bank, I. (2020) Editorial: γδ T Cells in Cancer. Frontiers in Immunology, 11, (doi: 10.3389/fimmu.2020.602411)

Fercoq, F., Remion, E., Vallarino-Lhermitte, N., Alonso, J., Raveendran, L., Nixon, C., Le Quesne, J., Carlin, L. M., Martin, C. (2020) Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents. Parasites and Vectors, 13, (doi: 10.1186/s13071-020-04428-0)

Beer, P. A., Cooke, S. L., Chang, D. K., Biankin, A. V. (2020) Defining the clinical genomic landscape for real-world precision oncology. Genomics, 112, pp. 5324-5330. (doi: 10.1016/j.ygeno.2020.10.032)

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J., Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298, pp. 198-217. (doi: 10.1111/imr.12916)

Stöhr, D., Schmid, J. O., Beigl, T. B., Mack, A., Maichl, D. S., Cao, K., Budai, B., Fullstone, G., Kontermann, R. E., Mürdter, T. E., Tait, S. W.G., Hagenlocher, C., Pollak, N., Scheurich, P., Rehm, M. (2020) Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death and Differentiation, 27, pp. 3037-3052. (doi: 10.1038/s41418-020-0559-3)

Middleton, M. R., McAlpine, C., Woodcock, V. K., Corrie, P., Infante, J. R., Steven, N. M., Evans, T. R. J., Anthoney, A., Shoushtari, A. N., Hamid, O., Gupta, A., Vardeu, A., Leach, E., Naidoo, R., Stanhope, S., Lewis, S., Hurstb, J., O’Kelly, I., Sznol, M. (2020) Tebentafusp, a TCR/anti-CD3 bispecific fusion protein targeting gp100, potently activated antitumor immune responses in patients with metastatic melanoma. Clinical Cancer Research, 26, pp. 5869-5878. (doi: 10.1158/1078-0432.CCR-20-1247)

Kristeleit, R. et al. (2020) Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours. British Journal of Cancer, 123, pp. 1360-1369. (doi: 10.1038/s41416-020-1010-8)

Alexander, P.G., Roseweir, A.K., Pennel, K.A.F., van Wyk, H.C., Powell, A.G.M.T., McMillan, D.C., Horgan, P.G., Kelly, C., Hay, J., Sansom, O., Harkin, A., Roxburgh, C.S.D., Graham, J., Church, D.N., Tomlinson, I., Saunders, M., Iveson, T.J., Edwards, J., Park, J.H. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x)

Roseweir, A. K., Park, J. H., ten Hoorn, S., Powell, A. G.M.T., Aherne, S., Roxburgh, C. S.D., McMillan, D. C., Horgan, P. G., Ryan, E., Sheahan, K., Vermeulen, L., Paul, J., Harkin, A., Graham, J., Sansom, O., Church, D. N., Tomlinson, I., Saunders, M., Iveson, T. J., Edwards, J. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6, pp. 283-296. (doi: 10.1002/cjp2.171)

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, (doi: 10.1038/s41598-020-72322-x)

Bailey, M. H. et al. (2020) Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11, (doi: 10.1038/s41467-020-18151-y)

Jones, C. M., Radhakrishna, G., Aitken, K., Bridgewater, J., Corrie, P., Eatock, M., Goody, R., Ghaneh, P., Good, J., Grose, D., Holyoake, D., Hunt, A., Jamieson, N. B., Palmer, D. H., Soonawalla, Z., Valle, J. W., Hawkins, M. A., Mukherjee, S. (2020) Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position. British Journal of Cancer, 123, pp. 709-713. (doi: 10.1038/s41416-020-0980-x)

Moekotte, A. L. et al. (2020) Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. European Journal of Surgical Oncology, 46, pp. 1717-1726. (doi: 10.1016/j.ejso.2020.04.011)

Li, C. H. et al. (2020) Sex differences in oncogenic mutational processes. Nature Communications, 11, (doi: 10.1038/s41467-020-17359-2)

Ahmed, A. A., Angell, R., Oxenford, S., Worthington, J., Williams, N., Barton, N., Fowler, T. G., O’Flynn, D. E., Sunose, M., McConville, M., Vo, T., Wilson, W. D., Karim, S. A., Morton, J. P., Neidle, S. (2020) Asymmetrically substituted quadruplex-binding naphthalene diimide showing potent activity in pancreatic cancer models. ACS Medicinal Chemistry Letters, 11, pp. 1634-1644. (doi: 10.1021/acsmedchemlett.0c00317)

Roca Portoles, A., Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O'Neill, K., Lemgruber Soares, L., Luo, X., Tait, S. W.G. (2020) Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell Death and Disease, 11, (doi: 10.1038/s41419-020-02867-2)

Wei, Q., Young, J., Holle, A., Li, J., Bieback, K., Inman, G., Spatz, J. P., Cavalcanti-Adam, E. A. (2020) Soft hydrogels for balancing cell proliferation and differentiation. ACS Biomaterials Science and Engineering, 6, pp. 4687-4701. (doi: 10.1021/acsbiomaterials.0c00854)

Wei, Q., Holle, A., Liu, J., Posa, F., Biagioni, F., Croci, O., Benk, A. S., Young, J., Noureddine, F., Deng, J., Zhang, M., Inman, G. J., Spatz, J. P., Campaner, S., Cavalcanti‐Adam, E. A. (2020) BMP‐2 signaling and mechanotransduction synergize to drive osteogenic differentiation via YAP/TAZ. Advanced Science, 7, (doi: 10.1002/advs.201902931)

Moekotte, A.L. et al. (2020) Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study. British Journal of Surgery, 107, pp. 1171-1182. (doi: 10.1002/bjs.11555)

Sarker, D., Plummer, R., Meyer, T., Sodergren, M. H., Basu, B., Chee, C. E., , (2020) MTL-CEBPA, a small activating RNA therapeutic upregulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multicenter, open-label, phase I trial. Clinical Cancer Research, 26, pp. 3936-3946. (doi: 10.1158/1078-0432.CCR-20-0414)

Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272, pp. 366-376. (doi: 10.1097/SLA.0000000000003143)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M., Blyth, K., Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14, pp. 1868-1880. (doi: 10.1002/1878-0261.12734)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S., Blyth, K., Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12, (doi: 10.3390/nu12082181)

Briggs, A., Daniele, B., Dick, K., Evans, T. R. J., Galle, P. R., Hubner, R. A., Lopez, C., Siebert, U., Tremblay, G. (2020) Covariate-adjusted analysis of the Phase 3 REFLECT study of lenvatinib versus sorafenib in the treatment of unresectable hepatocellular carcinoma. British Journal of Cancer, 122, pp. 1754-1759. (doi: 10.1038/s41416-020-0817-7)

Corrie, P.G. et al. (2020) Scheduling nab-paclitaxel combined with gemcitabine as first line treatment for metastatic pancreatic adenocarcinoma. British Journal of Cancer, 122, pp. 1760-1768. (doi: 10.1038/s41416-020-0846-2)

Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J.-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F., Carlin, L. M., Furley, A. J.W., Whyte, M. K.B., Walmsley, S. R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. Journal of Clinical Investigation, 130, pp. 3221-3237. (doi: 10.1172/JCI130834)

Pillay, J., Tregay, N., Juzenaite, G., Carlin, L. M., Pirillo, C., Gaboriau, D. C.A., Farahi, N., Summers, C., Lo Celso, C., Chilvers, E. R., Rankin, S., De Filippo, K. (2020) Effect of the CXCR4 antagonist plerixafor on endogenous neutrophil dynamics in the bone marrow, lung and spleen. Journal of Leukocyte Biology, 107, pp. 1175-1185. (doi: 10.1002/JLB.1MA0420-571RR)

Rooney, N., Mason, S. M., McDonald, L., Däbritz, J. H. M., Campbell, K. J., Hedley, A., Howard, S., Athineos, D., Nixon, C., Clark, W., Leach, J. D., Sansom, O. J., Edwards, J., Cameron, E. R., Blyth, K. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80, pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870)

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., Neidler, S., Rink, C., Karim, S. A., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A. V., Carlin, L. M., Coffelt, S. B., Sansom, O. J., Morton, J. P., Murphy, D. J. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10, pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620)

Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107625)

Litchfield, K. et al. (2020) Representative sequencing: unbiased sampling of solid tumor tissue. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107550)

Riley, J. S., Tait, S. W.G. (2020) Mitochondrial DNA in inflammation and immunity. EMBO Reports, 21, (doi: 10.15252/embr.201949799)

Leung, E. Y.L., Ennis, D. P., Kennedy, P. R., Hansell, C., Dowson, S., Farquharson, M., Spiliopoulou, P., Nautiyal, J., McNamara, S., Carlin, L. M., Fisher, K., Davis, D. M., Graham, G., McNeish, I. A. (2020) NK cells augment oncolytic adenovirus cytotoxicity in ovarian cancer. Molecular Therapy - Oncolytics, 16, pp. 289-301. (doi: 10.1016/j.omto.2020.02.001)

Michalopoulou, E., Auciello, F. R., Bulusu, V., Strachan, D., Campbell, A. D., Tait-Mulder, J., Karim, S. A., Morton, J. P., Sansom, O. J., Kamphorst, J. J. (2020) Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition. Cell Reports, 30, pp. 2729-2742.e4. (doi: 10.1016/j.celrep.2020.01.080)

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, , Bailey, P. J., Chang, D. K., Cooke, S. L., Biankin, A. V., Duthie, F. R., Graham, J. S., Jamieson, N. B., Musgrove, E. A., Martin, S., Yuan, K., Wright, D. W., Oien, K. A. (2020) Pan-cancer analysis of whole genomes. Nature, 578, pp. 82-93. (doi: 10.1038/s41586-020-1969-6)

Jiao, W., Atwal, G., Polak, P., Karlic, R., Cuppen, E., PCAWG Tumor Subtypes and Clinical Translation Working Group, , Danyi, A., de Ridder, J., van Herpen, C., Lolkema, M. P., Steeghs, N., Getz, G., Morris, Q., Stein, L. D., PCAWG Consortium, , Bailey, P. J., Biankin, A. V., Chang, D. K., Cooke, S. L., Martin, S., Wright, D. W. (2020) A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nature Communications, 11, (doi: 10.1038/s41467-019-13825-8)

Patel, R., Brzezinska, E. A., Repiscak, P., Ahmad, I., Mui, E., Gao, M., Blomme, A., Harle, V., Tan, E. H., Malviya, G., Mrowinska, A., Loveridge, C. J., Rushworth, L. K., Edwards, J., Ntala, C., Nixon, C., Hedley, A., Mackay, G., Tardito, S., Sansom, O. J., Leung, H. Y. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80, pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684)

Alsina, A., Kudo, M., Vogel, A., Cheng, A.-L., Tak, W. Y., Ryoo, B.-Y., Evans, T. R. J., López López, C., Daniele, B., Misir, S., Ren, M., Izumi, N., Qin, S., Finn, R. S. (2020) Effects of subsequent systemic anticancer medication following first-line lenvatinib: a post hoc responder analysis from the phase 3 REFLECT study in unresectable hepatocellular carcinoma. Liver Cancer, 9, pp. 93-104. (doi: 10.1159/000504624)

Mohan, S., Foy, V., Ayub, M., Leong, H. S., Schofield, P., Sahoo, S., Descamps, T., Kilerci, B., Smith, N. K., Carter, M., Priest, L., Zhou, C., Carr, T. H., Miller, C., Faivre-Finn, C., Blackhall, F., Rothwell, D. G., Dive, C., Brady, G. (2020) Profiling of circulating free DNA using targeted and genome-wide sequencing in patients with SCLC. Journal of Thoracic Oncology, 15, pp. 216-230. (doi: 10.1016/j.jtho.2019.10.007)

Kennedy, S. A. et al. (2020) Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nature Communications, 11, (doi: 10.1038/s41467-019-14224-9)

Wilson, D. H., Jarman, E. J., Mellin, R. P., Wilson, M. L., Waddell, S. H., Tsokkou, P., Younger, N. T., Raven, A., Bhalla, S. R., Noll, A. T. R., Olde Damink, S. W., Schaap, F. G., Chen, P., Bates, D. O., Banales, J. M., Dean, C. H., Henderson, D. J., Sansom, O. J., Kendall, T. J., Boulter, L. (2020) Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nature Communications, 11, (doi: 10.1038/s41467-020-14283-3)

Blagih, J., Zani, F., Chakravarty, P., Hennequart, M., Pilley, S., Hobor, S., Hock, A. K., Walton, J. B., Morton, J. P., Gronroos, E., Mason, S., Yang, M., Mcneish, I., Swanton, C., Blyth, K., Vousden, K. (2020) Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses. Cell Reports, 30, pp. 481-496.e6. (doi: 10.1016/j.celrep.2019.12.028)

Maniati, E., Berlato, C., Gopinathan, G., Heath, O., Kotantaki, P., Lakhani, A., McDermott, J., Pegrum, C., Delaine-Smith, R. M., Pearce, O. M.T., Hirani, P., Joy, J. D., Szabova, L., Perets, R., Sansom, O. J., Drapkin, R., Bailey, P., Balkwill, F. R. (2020) Mouse ovarian cancer models recapitulate the human tumor microenvironment and patient response to treatment. Cell Reports, 30, pp. 525-540.e7. (doi: 10.1016/j.celrep.2019.12.034)

RIFT Study Group, (2020) Evaluation of appendicitis risk prediction models in adults with suspected appendicitis. British Journal of Surgery, 107, pp. 73-86. (doi: 10.1002/bjs.11440)

Dreyer, S.B., Jamieson, N.B., Cooke, S.L., Valle, J.W., McKay, C.J., Biankin, A.V., Chang, D.K. (2020) PRECISION-Panc: the next generation therapeutic development platform for pancreatic cancer. Clinical Oncology, 32, pp. 1-4. (doi: 10.1016/j.clon.2019.07.011)

Dreyer, S.B., Jamieson, N.B., Morton, J.P., Sansom, O.J., Biankin, A.V., Chang, D.K. (2020) Pancreatic cancer: from genome discovery to PRECISION-Panc. Clinical Oncology, 32, pp. 5-8. (doi: 10.1016/j.clon.2019.08.007)

Cebon, J. S. et al. (2020) Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma. Journal for ImmunoTherapy of Cancer, 8, (doi: 10.1136/jitc-2019-000410)

McGregor, G. H., Campbell, A. D., Fey, S. K., Tumanov, S., Sumpton, D., Rodriguez Blanco, G., Mackay, G., Nixon, C., Vazquez, A., Sansom, O. J., Kamphorst, J. J. (2020) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, 80, pp. 175-188. (doi: 10.1158/0008-5472.CAN-19-0644)

Bock, F. J., Tait, S. W.G. (2020) Mitochondria as multifaceted regulators of cell death. Nature Reviews Molecular Cell Biology, 21, pp. 85-100. (doi: 10.1038/s41580-019-0173-8)

Liko, D., Mitchell, L., Campbell, K., Ridgway, R., Jones, C., Dudek, K., King, A., Bryson, S., Stevenson, D., Blyth, K., Strathdee, D., Morton, J. P., Bird, T., Knight, J. R.P., Willis, A. E., Sansom, O. J. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26, pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7)

Patel, D. F., Peiró, T., Bruno, N., Vuononvirta, J., Akthar, S., Puttur, F., Pyle, C. J., Suveizdytė, K., Walker, S. A., Singanayagam, A., Carlin, L. M., Gregory, L. G., Lloyd, C. M., Snelgrove, R. J. (2019) Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation. Science Immunology, 4, (doi: 10.1126/sciimmunol.aax7006)

Malik, N., Dunn, K. M., Cassels, J., Hay, J., Estell, C., Sansom, O. J., Michie, A. M. (2019) mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Scientific Reports, 9, (doi: 10.1038/s41598-019-53141-1)

Schmidt, S. et al. (2019) A MYC/GCN2/eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature Cell Biology, 21, pp. 1413-1424. (doi: 10.1038/s41556-019-0408-0)

Naumann, R. W., Hollebecque, A., Meyer, T., Devlin, M.-J., Oaknin, A., Kerger, J., López-Picazo, J. M., Machiels, J.-P., Delord, J.-P., Evans, T. R.J., Boni, V., Calvo, E., Topalian, S. L., Chen, T., Soumaoro, I., Li, B., Gu, J., Zwirtes, R., Moore, K. N. (2019) Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: Results from the phase I/II CheckMate 358 trial. Journal of Clinical Oncology, 37, pp. 2825-2834. (doi: 10.1200/JCO.19.00739)

Pereira, B. A., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P., Cox, T. R., Timpson, P. (2019) CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer. Trends in Cancer, 5, pp. 724-741. (doi: 10.1016/j.trecan.2019.09.010)

Beer, P. A., Cooke, S. L., Chang, D. K., Biankin, A. V. (2019) Reasons to be testing: the dawn of complex molecular profiling in routine oncology practice. Annals of Oncology, 30, pp. 1691-1694. (doi: 10.1093/annonc/mdz392)

Bott, A. J. et al. (2019) Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Reports, 29, pp. 1287-1298.e6. (doi: 10.1016/j.celrep.2019.09.056)

Jones, R. L. et al. (2019) Phase II randomised discontinuation trial of brivanib in patients with advanced solid tumours. European Journal of Cancer, 120, pp. 132-139. (doi: 10.1016/j.ejca.2019.07.024)

Tandon, M., Coudriet, G. M., Criscimanna, A., Socorro, M., Eliliwi, M., Singhi, A. D., Cruz-Monserrate, Z., Bailey, P., Lotze, M. T., Zeh, H., Hu, J., Goffin, V., Gittes, G. K., Biankin, A. V., Esni, F. (2019) Prolactin promotes fibrosis and pancreatic cancer progression. Cancer Research, 79, pp. 5316-5327. (doi: 10.1158/0008-5472.CAN-18-3064)

Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25, pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1)

Al-Mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Gilmour, L., Foster, J., Chalmers, A.J., Holmes, W.M. (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: application to an infiltrative brain tumour model. Journal of Neuroscience Methods, 326, (doi: 10.1016/j.jneumeth.2019.108372)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36, pp. 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003)

McCormick, B., Craig, H. E., Chu, J. Y., Carlin, L. M., Canel, M., Wollweber, F., Toivakka, M., Michael, M., Astier, A. L., Norton, L., Lilja, J., Felton, J. M., Sasaki, T., Ivaska, J., Hers, I., Dransfield, I., Rossi, A. G., Vermeren, S. (2019) A negative feedback loop regulates integrin inactivation and promotes neutrophil recruitment to inflammatory sites. Journal of Immunology, 203, pp. 1579-1588. (doi: 10.4049/jimmunol.1900443)

Wellenstein, M. D., Coffelt, S. B., Duits, D. E.M., van Miltenburg, M. H., Slagter, M., de Rink, I., Henneman, L., Kas, S. M., Prekovic, S., Hau, C.-S., Vrijland, K., Drenth, A. P., de Korte-Grimmerink, R., Schut, E., van der Heijden, I., Zwart, W., Wessels, L. F.A., Schumacher, T. N.M., Jonkers, J., de Visser, K. E. (2019) Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis. Nature, 572, pp. 538-542. (doi: 10.1038/s41586-019-1450-6)

Mackey, J. B.G., Coffelt, S. B., Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, (doi: 10.3389/fimmu.2019.01912)

Vennin, C. et al. (2019) CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, (doi: 10.1038/s41467-019-10968-6)

Janssen, Q. P. et al. (2019) Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis. Journal of the National Cancer Institute, 111, pp. 782-794. (doi: 10.1093/jnci/djz073)

Vallatos, A., Al-Mubarak, H.F.I., Birch, J.L., Gallagher, L., Mullin, J.M., Gilmour, L., Holmes, W.M., Chalmers, A.J. (2019) Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. Journal of Magnetic Resonance Imaging, 50, pp. 529-540. (doi: 10.1002/jmri.26580)

Orozco, S. L., Daniels, B. P., Yatim, N., Messmer, M. N., Quarato, G., Chen-Harris, H., Cullen, S. P., Snyder, A. G., Ralli-Jain, P., Frase, S., Tait, S. W.G., Green, D. R., Albert, M. L., Oberst, A. (2019) RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity. Cell Reports, 28, pp. 2275-2287.e5. (doi: 10.1016/j.celrep.2019.07.077)

Evans, T. R. J., Kudo, M., Finn, R. S., Han, K.-H., Cheng, A.-L., Ikeda, M., Kraljevic, S., Ren, M., Ductus, C. E., Piscaglia, F., Sung, M. W. (2019) Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. British Journal of Cancer, 121, pp. 218-221. (doi: 10.1038/s41416-019-0506-6)

Reader, C. S., Vallath, S., Steele, C. W., Haider, S., Brentnall, A., Desai, A., Moore, K. M., Jamieson, N. B., Chang, D., Bailey, P., Scarpa, A., Lawlor, R., Chelala, C., Keyse, S. M., Biankin, A., Morton, J. P., Evans, T.R. J., Barry, S. T., Sansom, O. J., Kocher, H. M., Marshall, J. F. (2019) The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology, 249, pp. 332-342. (doi: 10.1002/path.5320)

Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G., Blyth, K., Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26, pp. 183-194. (doi: 10.1038/s41417-018-0039-9)

Seykora, T. F., Ecker, B. L., McMillan, M. T., Maggino, L., Beane, J. D., Fong, Z. V., Hollis, R. H., Jamieson, N. B., Javed, A. A., Kowalsky, S. J., Kunstman, J. W., Malleo, G., Poruk, K. E., Soares, K., Valero, V., Velu, L. K. P., Watkins, A. A., Vollmer, C. M. (2019) The beneficial effects of minimizing blood loss in pancreatoduodenectomy. Annals of Surgery, 270, pp. 147-157. (doi: 10.1097/SLA.0000000000002714)

Silva-Santos, B., Mensurado, S., Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19, pp. 392-404. (doi: 10.1038/s41568-019-0153-5)

Vringer, E., Tait, S. W.G. (2019) Mitochondria and inflammation: cell death heats up. Frontiers in Cell and Developmental Biology, 7, (doi: 10.3389/fcell.2019.00100)

Hari, P., Millar, F. R., Tarrats, N., Birch, J., Quintanilla, A., Rink, C. J., Fernández-Duran, I., Muir, M., Finch, A. J., Brunton, V. G., Passos, J. F., Morton, J. P., Boulter, L., Acosta, J. C. (2019) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Science Advances, 5, (doi: 10.1126/sciadv.aaw0254)

Halbrook, C. J., Pontious, C., Kovalenko, I., Lapienyte, L., Dreyer, S., Lee, H.-J., Thurston, G., Zhang, Y., Lazarus, J., Sajjakulnukit, P., Hong, H. S., Kremer, D. M., Nelson, B. S., Kemp, S., Zhang, L., Chang, D., Biankin, A., Shi, J., Frankel, T. L., Crawford, H. C., Morton, J. P., Pasca di Magliano, M., Lyssiotis, C. A. (2019) Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer. Cell Metabolism, 29, pp. 1390-1399.e6. (doi: 10.1016/j.cmet.2019.02.001)

Leach, J., Morton, J. P., Sansom, O. J. (2019) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, 110, pp. 69-76. (doi: 10.1016/j.molimm.2017.12.013)

Puttur, F., Denney, L., Gregory, L. G., Vuononvirta, J., Oliver, R., Entwistle, L. J., Walker, S. A., Headley, M. B., McGhee, E., Pease, J. E., Krummel, M. F., Carlin, L., Lloyd, C. M. (2019) Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans. Science Immunology, 4, (doi: 10.1126/sciimmunol.aav7638)

Memon, D., Bi, J., Miller, C. J. (2019) In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. Scientific Reports, 9, (doi: 10.1038/s41598-019-43758-7)

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., Vringer, E., Schug, M., Novo, D., Hwang, R. F., Evans, R. M., Nixon, C., Dorrell, C., Morton, J. P., Norman, J. C., Sears, R. C., Kamphorst, J. J., Sherman, M. H. (2019) A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery, 9, pp. 617-627. (doi: 10.1158/2159-8290.CD-18-1212)

Badshah, I.I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., O'Shaughnessy, R.F.L. (2019) Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology, 180, pp. 1135-1149. (doi: 10.1111/bjd.17352)

Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25, pp. 738-743. (doi: 10.1038/s41591-019-0380-z)

Neves, K. B., Rios, F. J., Jones, R., Evans, T. R. J., Montezano, A. C., Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115, pp. 978-988. (doi: 10.1093/cvr/cvz021)

Johansson, J., Naszai, M., Hodder, M. C., Pickering, K. A., Miller, B. W., Ridgway, R. A., Yu, Y., Peschard, P., Brachmann, S., Campbell, A. D., Cordero, J. B., Sansom, O. J. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, 24, pp. 592-607.E7. (doi: 10.1016/j.stem.2019.02.002)

Conway, J. R.W., Herrmann, D., Evans, T.R. J., Morton, J. P., Timpson, P. (2019) Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine. Gut, 68, pp. 742-758. (doi: 10.1136/gutjnl-2018-316822)

Dreyer, S. B., Jamieson, N. B., Evers, L., Duthie, F., Cooke, S., Marshall, J., Beraldi, D., Knight, S., Upstill-Goddard, R., Dickson, E. J., Carter, C. R., McKay, C. J., Biankin, A. V., Chang, D. K. (2019) Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. Chinese Clinical Oncology, 8, (doi: 10.21037/cco.2019.04.06)

Collisson, E. A., Bailey, P., Chang, D. K., Biankin, A. V. (2019) Molecular subtypes of pancreatic cancer. Nature Reviews Gastroenterology and Hepatology, 16, pp. 207-220. (doi: 10.1038/s41575-019-0109-y)

Baquero, P., Dawson, A., Mukhopadhyay, A., Kuntz, E. M., Mitchell, R., Olivares, O., Ianniciello, A., Scott, M. T., Dunn, K., Nicastri, M. C., Winkler, J. D., Michie, A. M., Ryan, K. M., Halsey, C., Gottlieb, E., Keaney, E. P., Murphy, L. O., Amaravadi, R. K., Holyoake, T. L., Helgason, G. V. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33, pp. 981-994. (doi: 10.1038/s41375-018-0252-4)

Salvagno, C., Ciampricotti, M., Tuit, S., Hau, C.-S., van Weverwijk, A., Coffelt, S. B., Kersten, K., Vrijland, K., Kos, K., Ulas, T., Song, J.-Y., Ooi, C.-H., Rüttinger, D., Cassier, P. A., Jonkers, J., Schultze, J. L., Ries, C. H., de Visser, K. E. (2019) Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology, 21, pp. 511-521. (doi: 10.1038/s41556-019-0298-1)

Twelves, C., Anthoney, A., Savulsky, C. I., Guo, M., Reyderman, L., Cresti, N., Semiglazov, V., Timcheva, C., Zubairi, I., Morrison, R., Plummer, R., Evans, T.R. J. (2019) A phase 1b/2, open-label, dose-escalation, and dose-confirmation study of eribulin mesilate in combination with capecitabine. British Journal of Cancer, 120, pp. 579-586. (doi: 10.1038/s41416-018-0366-5)

Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., Evans, J., Hall, J. A., Kinrade, S., Jones, D., Jones, P. S., Jones, R., Marshall, J. F., Panico, M. B., Shaw, J. A., Steeg, P. S., Sullivan, M., Tong, W., Westwell, A. D., Ritchie, J. W.A. (2019) A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology, 16, pp. 185-204. (doi: 10.1038/s41571-018-0134-8)

Cosimo, E., Tarafdar, A., Moles, M. W., Holroyd, A. K., Malik, N., Catherwood, M. A., Hay, J., Dunn, K. M., Macdonald, A. M., Guichard, S. M., O'Rourke, D. M., Leach, M. T., Sansom, O. J., Cosulich, S. C., McCaig, A. M., Michie, A. M. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25, pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036)

Singh, G., Nahm, C. B., Jamieson, N. B., Chua, T. C., Wong, S., Thoo, C., Mittal, A., Gill, A. J., Samra, J. S. (2019) Management of post-pancreatectomy haemorrhage using resuscitative endovascular balloon occlusion of the aorta. Langenbeck's Archives of Surgery, 404, pp. 253-255. (doi: 10.1007/s00423-019-01759-0)

Strijker, M., Chen, J.W., Mungroop, T.H., Jamieson, N.B., van Eijck, C.H., Steyerberg, E.W., Wilmink, J.W., Groot Koerkamp, B., van Laarhoven, H.W., Besselink, M.G. (2019) Systematic review of clinical prediction models for survival after surgery for resectable pancreatic cancer. British Journal of Surgery, 106, pp. 342-354. (doi: 10.1002/bjs.11111)

Gay, D. M., Ridgway, R. A., Müeller, M., Hodder, M. C., Hedley, A., Clark, W., Leach, J. D., Jackstadt, R., Nixon, C., Huels, D. J., Campbell, A. D., Bird, T. G., Sansom, O. J. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, (doi: 10.1038/s41467-019-08586-3)

Beauvarlet, J., Bensadoun, P., Darbo, E., Labrunie, G., Rousseau, B., Richard, E., Draskovic, I., Londono-Vallejo, A., Dupuy, J.-W., Nath Das, R., Guédin, A., Robert, G., Orange, F., Croce, S., Valesco, V., Soubeyran, P., Ryan, K. M., Mergny, J.-L., Djavaheri-Mergny, M. (2019) Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells. Nucleic Acids Research, 47, pp. 2739-2756. (doi: 10.1093/nar/gkz095)

Kugeratski, F. G., Atkinson, S. J., Neilson, L. J., Lilla, S., Knight, J. R.P., Serneels, J., Juin, A., Ismail, S., Bryant, D. M., Markert, E. K., Machesky, L. M., Mazzone, M., Sansom, O. J., Zanivan, S. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12, (doi: 10.1126/scisignal.aan8247)

Nahm, C. B., Turchini, J., Jamieson, N., Moon, E., Sioson, L., Itchins, M., Arena, J., Colvin, E., Howell, V. M., Pavlakis, N., Clarke, S., Samra, J. S., Gill, A. J., Mittal, A. (2019) Biomarker panel predicts survival after resection in pancreatic ductal adenocarcinoma: a multi-institutional cohort study. European Journal of Surgical Oncology, 45, pp. 218-224. (doi: 10.1016/j.ejso.2018.10.050)

Parry, M. A., Srivastava, S., Ali, A., Cannistraci, A., Antonello, J., Barros-Silva, J. D., Ubertini, V., Ramani, V., Lau, M., Shanks, J., Nonaka, D., Oliveira, P., Hambrock, T., Leong, H. S., Dhomen, N., Miller, C., Brady, G., Dive, C., Clarke, N. W., Marais, R., Baena, E. (2019) Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer. European Urology Oncology, 2, pp. 1-11. (doi: 10.1016/j.euo.2018.08.005)

Maggino, L., Malleo, G., Bassi, C., Allegrini, V., Beane, J. D., Beckman, R. M., Chen, B., Dickson, E. J., Drebin, J. A., Ecker, B. L., Fraker, D. L., House, M. G., Jamieson, N. B., Javed, A. A., Kowalsky, S. J., Lee, M. K., McMillan, M. T., Roses, R. E., Salvia, R., Valero, V., Velu, L. K. P., Wolfgang, C. L., Zureikat, A. H., Vollmer, C. M. (2019) Identification of an optimal cut-off for drain fluid amylase on postoperative day 1 for predicting clinically relevant fistula after distal pancreatectomy. Annals of Surgery, 269, pp. 337-343. (doi: 10.1097/SLA.0000000000002532)

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L. S., Sansom, O. J., Barry, S. T., Inman, G. I. (2019) Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor β superfamily type 1 receptors. Molecular Pharmacology, 95, pp. 222-234. (doi: 10.1124/mol.118.112946)

Evans, T.R. J., Dean, E., Molife, L. R., Lopez, J., Ranson, M., El-Khouly, F., Zubairi, I., Savulsky, C., Reyderman, L., Jia, Y., Sweeting, L., Greystroke, A., Barriuso, J., Kristeleit, R. (2019) Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours. British Journal of Cancer, (doi: 10.1038/s41416-019-0377-x)

Lallo, A., Gulati, S., Schenk, M. W., Khandelwal, G., Berglund, U. W., Pateras, I. S., Chester, C. P. E., Pham, T. M., Kalderen, C., Frese, K. K., Gorgoulis, V. G., Miller, C., Blackhall, F., Helleday, T., Dive, C. (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176, pp. 436-450. (doi: 10.1111/bph.14542)

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C. D., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G., Sears, R. C. (2019) Activation of PP2A and Inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma. Cancer Research, 79, pp. 209-219. (doi: 10.1158/0008-5472.CAN-18-0717)

Ecker, B. L. et al. (2019) Risk factors and mitigation strategies for pancreatic fistula after distal pancreatectomy. Annals of Surgery, 269, pp. 143-149. (doi: 10.1097/SLA.0000000000002491)

Menon, M., Elliott, R., Bowers, L., Balan, N., Rafiq, R., Costa-Cabral, S., Munkonge, F., Trinidade, I., Porter, R., Campbell, A. D., Johnson, E. R., Esdar, C., Buchstaller, H.-P., Leuthner, B., Rohdich, F., Schneider, R., Sansom, O., Wienke, D., Ashworth, A., Lord, C. J. (2019) A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific Reports, 9, (doi: 10.1038/s41598-018-36447-4)

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J., Leigh, I. M. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20, (doi: 10.3390/ijms20143428)

Lopez, J., Tait, S. W.G. (2019) Application of mito-priming to generate BCL-2 addicted cells. Humana Press

Beaumatin, F., O'Prey, J., Barthet, V. J.A., Zunino, B., Parvy, J.-P., Bachmann, A. M., O'Prey, M., Kania, E., Gonzalez, P. S., Macintosh, R., Lao, L. Y., Nixon, C., Lopez, J., Long, J. S., Tait, S. W.G., Ryan, K. N. (2019) DRAM-1 is required for mTORC1 activation by facilitating lysosomal amino acid efflux. Molecular Cell, 76, pp. 163-176.E8. (doi: 10.1016/j.molcel.2019.07.021)

Rohwer, N. et al. (2019) Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene, 38, pp. 5670-5685. (doi: 10.1038/s41388-019-0816-4)

Kim, C. S., Mohan, S., Ayub, M., Rothwell, D. G., Dive, C., Brady, G., Miller, C. (2018) In silico error correction improves cfDNA mutation calling. Bioinformatics, 35, pp. 2380-2385. (doi: 10.1093/bioinformatics/bty1004)

Chou, A. et al. (2018) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut, 67, pp. 2142-2155. (doi: 10.1136/gutjnl-2017-315144)

Pinho, A. V., Van Bulck, M., Chantrill, L., Arshi, M., Sklyarova, T., Herrmann, D., Vennin, C., Gallego-Ortega, D., Mawson, A., Giry-Laterriere, M., Magenau, A., Leuckx, G., Baeyens, L., Gill, A. J., Phillips, P., Timpson, P., Biankin, A. V., Wu, J., Rooman, I. (2018) ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling. Nature Communications, 9, (doi: 10.1038/s41467-018-07497-z)

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, (doi: 10.1038/s41467-018-07339-y)

Chauhan, D., Bartok, E., Gaidt, M. M., Bock, F. J., Herrmann, J., Seeger, J. M., Broz, P., Beckmann, R., Kashkar, H., Tait, S. W.G., Müller, R., Hornung, V. (2018) BAX/BAK induced apoptosis results in caspase-8 dependent IL-1β maturation in macrophages. Cell Reports, 25, pp. 2354-2368.e5. (doi: 10.1016/j.celrep.2018.10.087)

Veenstra, V.L., Damhofer, H., Waasdorp, C., van Rijssen, L.B., van de Vijver, M.J., Dijk, F., Wilmink, H.W., Besselink, M.G., Busch, O.R., Chang, D.K., Bailey, P.J., Biankin, A.V., Kocher, H.M., Medema, J.P., Li, J.S., Jiang, R., Pierce, D.W., van Laarhoven, H.W.M., Bijlsma, M.F. (2018) ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy. Oncogenesis, 7, (doi: 10.1038/s41389-018-0096-9)

Greenhough, A., Bagley, C., Heesom, K. J., Gurevich, D. B., Gay, D., Bond, M., Collard, T. J., Paraskeva, C., Martin, P., Sansom, O. J., Malik, K., Williams, A. C. (2018) Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis. EMBO Molecular Medicine, 10, (doi: 10.15252/emmm.201708699)

Birch, J. L., Strathdee, K., Gilmour, L., Vallatos, A., McDonald, L., Kouzeli, A., Vasan, R., Qaisi, A. H., Croft, D. R., Crighton, D., Gill, K., Gray, C. H., Konczal, J., Mezna, M., McArthur, D., Schüttelkopf, A. W., McConnell, P., Sime, M., Holmes, W. M., Bower, J., McKinnon, H. J., Drysdale, M., Olson, M. F., Chalmers, A. J. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78, pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697)

Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J., Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, 246, pp. 331-343. (doi: 10.1002/path.5143)

Malik, N., Sansom, O. J., Michie, A. M. (2018) The role of mTOR-mediated signals during haemopoiesis and lineage commitment. Biochemical Society Transactions, 46, pp. 1313-1324. (doi: 10.1042/BST20180141)

Janjigian, Y. Y., Bendell, J., Calvo, E., Kim, J. W., Ascierto, P. A., Sharma, P., Ott, P. A., Peltola, K., Jaeger, D., Evans, J., de Braud, F., Chau, I., Harbison, C. T., Dorange, C., Tschaika, M., Le, D. T. (2018) CheckMate-032 study: efficacy and safety of nivolumab and nivolumab plus ipilimumab in patients with metastatic esophagogastric cancer. Journal of Clinical Oncology, 36, pp. 2836-2844. (doi: 10.1200/JCO.2017.76.6212)

Flanagan, D.J., Hodder, M.C., Sansom, O.J. (2018) Microenvironmental cues in cancer stemness. Nature Cell Biology, 20, pp. 1102-1104. (doi: 10.1038/s41556-018-0210-4)

Lindsay, C. R. et al. (2018) Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme. ESMO Open, 3, (doi: 10.1136/esmoopen-2018-000408)

Lallo, A., Frese, K. K., Morrow, C. J., Sloane, R., Gulati, S., Schenk, M. W., Trapani, F., Simms, N., Galvin, M., Brown, S., Hodgkinson, C. L., Priest, L., Hughes, A., Lai, Z., Cadogan, E., Khandelwal, G., Simpson, K. L., Miller, C., Blackhall, F., O'Connor, M. J., Dive, C. (2018) The combination of the PARP inhibitor Olaparib and the WEE1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer. Clinical Cancer Research, 24, pp. 5153-5164. (doi: 10.1158/1078-0432.CCR-17-2805)

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M., Leigh, I. M. (2018) The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications, 9, (doi: 10.1038/s41467-018-06027-1)

Riley, J. S., Quarato, G., Cloix, C., Lopez, J., O'Prey, J., Pearson, M., Chapman, J., Sesaki, H., Carlin, L. M., Passos, J. F., Wheeler, A. P., Oberst, A., Ryan, K. M., Tait, S. W.G. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37, (doi: 10.15252/embj.201899238)

Basu, B. et al. (2018) Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of Oncology, 29, pp. 1918-1925. (doi: 10.1093/annonc/mdy245)

Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aan1230)

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Meijden, E. V. d., Inman, G. J., South, A. P., Leigh, I. M., Harwood, C. A. (2018) The role of human papillomaviruses and polyomaviruses in BRAF-inhibitor induced cutaneous squamous cell carcinoma and benign squamoproliferative lesions. Frontiers in Microbiology, 9, (doi: 10.3389/fmicb.2018.01806)

Mackay, H. L., Moore, D., Hall, C., Birkbak, N. J., Jamal-Hanjani, M., Karim, S. A., Phatak, V. M., Piñon, L., Morton, J. P., Swanton, C., Le Quesne, J., Muller, P. A.J. (2018) Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9, (doi: 10.1038/s41467-018-05368-1)

Krol, I., Castro-Giner, F., Maurer, M., Gkountela, S., Szczerba, B., Scherrer, R., Coleman, N., Carreira, S., Bachmann, F., Anderson, S., Engelhardt, M., Lane, H., Evans, T. R. J., Plummer, R., Kristeleit, R., Lopez, J., Aceto, N. (2018) Detection of circulating tumor cell clusters in human glioblastoma. British Journal of Cancer, 119, pp. 487-491. (doi: 10.1038/s41416-018-0186-7)

Baxter, M.A., Glen, H., Evans, T.R.J. (2018) Lenvatinib and its use in the treatment of unresectable hepatocellular carcinoma. Future Oncology, 14, pp. 2021-2029. (doi: 10.2217/fon-2017-0689)

Warren, S. C., Nobis, M., Magenau, A., Mohammed, Y. H., Herrmann, D., Moran, I., Vennin, C., Conway, J. R.W., Mélénec, P., Cox, T. R., Wang, Y., Morton, J. P., Welch, H. C.E., Strathdee, D., Anderson, K. I., Phan, T. G., Roberts, M. S., Timpson, P. (2018) Removing physiological motion from intravital and clinical functional imaging data. eLife, 7, (doi: 10.7554/elife.35800)

Morris, H. T., Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H., Snapper, S. B., Carey, F. A., Sansom, O. J., Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, 245, pp. 337-348. (doi: 10.1002/path.5086)

May, S., Owen, H., Phesse, T. J., Greenow, K. R., Jones, G.-R., Blackwood, A., Cook, P. C., Towers, C., Gallimore, A. M., Williams, G. T., Stürzl, M., Britzen-Laurent, N., Sansom, O. J., MacDonald, A. S., Bird, A. P., Clarke, A. R., Parry, L. (2018) Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology, 245, pp. 270-282. (doi: 10.1002/path.5074)

Torres-Ayuso, P., Sahoo, S., Ashton, G., An, E., Simms, N., Galvin, M., Leong, H. S., Frese, K. K., Simpson, K., Cook, N., Hughes, A., Miller, C. J., Marais, R., Dive, C., Krebs, M. G., Brognard, J. (2018) Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin. npj Genomic Medicine, 3, (doi: 10.1038/s41525-018-0055-6)

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P., Murphy, D. J. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aao2565)

Conway, J. R.W. et al. (2018) Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer. Cell Reports, 23, pp. 3312-3326. (doi: 10.1016/j.celrep.2018.05.038)

Hodder, M. C., Flanagan, D. J., Sansom, O. J. (2018) Intestinal stem cell dynamics: a story of mice and humans. Cell Stem Cell, 22, pp. 785-787. (doi: 10.1016/j.stem.2018.05.005)

Pearson, H. B., Li, J., Meniel, V. S., Fennell, C. M., Waring, P., Montgomery, K. G., Rebello, R. J., Macpherson, A. A., Koushyar, S., Furic, L., Cullinane, C., Clarkson, R. W., Smalley, M. J., Simpson, K. J., Phesse, T. J., Shepherd, P. R., Humbert, P. O., Sansom, O. J., Phillips, W. A. (2018) Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery, 8, pp. 764-779. (doi: 10.1158/2159-8290.CD-17-0867)

Godfrey, J. D., Morton, J. P., Wilczynska, A., Sansom, O. J., Bushell, M. D. (2018) MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0628-4)

Woroniuk, A., Porter, A., White, G., Newman, D. T., Diamantopoulou, Z., Waring, T., Rooney, C., Strathdee, D., Marston, D. J., Hahn, K. M., Sansom, O. J., Zech, T., Malliri, A. (2018) STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature Communications, 9, (doi: 10.1038/s41467-018-04404-4)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23, pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8, pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533)

Brown, E., Carlin, L. M., Nerlov, C., Lo Celso, C., Poole, A. W. (2018) Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels. Life Science Alliance, 1, (doi: 10.26508/lsa.201800061)

Ahmad, I., Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi: 10.1002/path.5029)

Convertino, M., Church, T. R., Olsen, G. W., Liu, Y., Doyle, E., Elcombe, C. R., Barnett, A. L., Samuel, L. M., MacPherson, I. R., Evans, T. R.J. (2018) Stochastic pharmacokinetic-pharmacodynamic modeling for assessing the systemic health risk of perfluorooctanoate (PFOA) Toxicological Sciences, 163, pp. 293-306. (doi: 10.1093/toxsci/kfy035)

Campbell, K. J., Tait, S. W.J. (2018) Targeting BCL-2 regulated apoptosis in cancer. Open Biology, 8, (doi: 10.1098/rsob.180002)

Mitchell, R., Hopcroft, L. E.M., Baquero, P., Allan, E. K., Hewit, K., James, D., Hamilton, G., Mukhopadhyay, A., O'Prey, J., Hair, A., Melo, J. V., Chan, E., Ryan, K. M., Maguer-Satta, V., Druker, B. J., Clark, R. E., Mitra, S., Herzyk, P., Nicolini, F. E., Salomoni, P., Helgason, G. V. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110, pp. 467-478. (doi: 10.1093/jnci/djx236)

Carvajal, R. D. et al. (2018) Selumetinib in combination with dacarbazine in patients with metastatic uveal melanoma: a phase III, multicentre, randomised trial (SUMIT) Journal of Clinical Oncology, 36, pp. 1232-1239. (doi: 10.1200/JCO.2017.74.1090)

Sheahan, A. V., Biankin, A. V., Parish, C. R., Khachigian, L. M. (2018) Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review. Oncotarget, 9, pp. 21613-21627. (doi: 10.18632/oncotarget.25085)

Tung, S. L., Boardman, D. A., Sen, M., Letizia, M., Peng, Q., Cianci, N., Dioni, L., Carlin, L. M., Lechler, R., Bollati, V.;e., Lombardi, G., Smyth, L. A. (2018) Regulatory T cell-derived extracellular vesicles modify dendritic cell function. Scientific Reports, 8, (doi: 10.1038/s41598-018-24531-8)

Hudson, A. M., Stephenson, N. L., Li, C., Trotter, E., Fletcher, A. J., Katona, G., Bieniasz-Krzywiec, P., Howell, M., Wirth, C., Furney, S., Miller, C. J., Brognard, J. (2018) Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. Science Signaling, 11, (doi: 10.1126/scisignal.aan6776)

Meiser, J., Schuster, A., Pietzke, M., Voore, J. V., Athineos, D., Oizel, K., Burgos-Barragan, G., Wit, N., Dhayade, S., Morton, J. P., Dornier, E., Sumpton, D., Mackay, G. M., Blyth, K., Patel, K. J., Niclou, S. P., Vazquez, A. (2018) Increased formate overflow is a hallmark of oxidative cancer. Nature Communications, 9, (doi: 10.1038/s41467-018-03777-w)

Patel, R., Fleming, J., Mui, E., Loveridge, C., Repiscak, P., Blomme, A., Harle, V., Salji, M., Ahmad, I., Teo, K., Hamdy, F. C., Hedley, A., van den Broek, N., Mackay, G., Edwards, J., Sansom, O. J., Leung, H. Y. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10, (doi: 10.15252/emmm.201708347)

Ecker, B. L. et al. (2018) Characterization and optimal management of high-risk pancreatic anastomoses during pancreatoduodenectomy. Annals of Surgery, 267, pp. 608-616. (doi: 10.1097/SLA.0000000000002327)

Kudo, M., Finn, R., Qin, S., Han, K.-H., Ikeda, K., Piscaglia, F., Baron, A., Park, J.-W., Han, G., Jassem, J., Blanc, J. F., Vogel, A., Komov, D., Evans, J., Lopez, C., Dutcus, C., Guo, M., Saito, K., Kraljevic, S., Tamai, T., Ren, M., Cheng, A.-L. (2018) Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet, 391, pp. 1163-1173. (doi: 10.1016/S0140-6736(18)30207-1)

Marchetti, C., Zyner, K. G., Ohnmacht, S. A., Robson, M., Haider, S. M., Morton, J. P., Marsico, G., Vo, T., Laughlin-Toth, S., Ahmed, A. A., Di Vita, G., Pazitna, I., Gunaratnam, M., Besser, R. J., Andrade, A. C.G., Diocou, S., Pike, J. A., Tannahill, D., Pedley, R. B., Evans, T.R. J., Wilson, W. D., Balasubramanian, S., Neidle, S. (2018) Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule. Journal of Medicinal Chemistry, 61, pp. 2500-2517. (doi: 10.1021/acs.jmedchem.7b01781)

Cook, N., Basu, B., Smith, D.-M., Gopinathan, A., Evans, T.R. J., Steward, W. P., Palmer, D., Propper, D., Venugopal, B., Hategan, M., Anthoney, D. A., Hampson, L. V., Nebozhyn, M., Tuveson, D., Farmer-Hall, H., Turner, H., McLeod, R., Halford, S., Jodrell, D. (2018) A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma. British Journal of Cancer, 118, pp. 793-801. (doi: 10.1038/bjc.2017.495)

Huels, D.J., Bruens, L., Hodder, M.C., Cammareri, P., Campbell, A.D., Ridgway, R.A., Gay, D.M., Solar Abboud, M., Faller, W.J., Nixon, C., Zeiger, L.B., McLaughlin, M.E., Morrissey, E., Winton, D.J., Snippert, H.J., van Rheenen, J., Sansom, O.J. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, (doi: 10.1038/s41467-018-03426-2)

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J., Inman, G. j. (2018) Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma. Oncotarget, 9, pp. 14552-14566. (doi: 10.18632/oncotarget.24545)

Chin, V., Nagrial, A., Sjoquist, K., O'Connor, C. A., Chantrill, L., Biankin, A. V., Scholten, R. J.P.M., Yip, D. (2018) Chemotherapy and radiotherapy for advanced pancreatic cancer. Cochrane Database of Systematic Reviews, 2018, (doi: 10.1002/14651858.cd011044.pub2)

Galluzzi, L. et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25, pp. 486-541. (doi: 10.1038/s41418-017-0012-4)

Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., Timpson, P. (2018) Reshaping the tumor stroma for treatment of pancreatic cancer. Gastroenterology, 154, pp. 820-838. (doi: 10.1053/j.gastro.2017.11.280)

Vlachogiannis, G. et al. (2018) Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science, 359, pp. 920-926. (doi: 10.1126/science.aao2774)

Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J., Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37, pp. 982-992. (doi: 10.1038/onc.2017.394)

Grant, R. C., Denroche, R. E., Borgida, A., Virtanen, C., Cook, N., Smith, A. L., Connor, A. A., Wilson, J. M., Peterson, G., Roberts, N. J., Klein, A. P., Grimmond, S. M., Biankin, A., Cleary, S., Moore, M., Lemire, M., Zogopolous, G., Stein, L., Gallinger, S. (2018) Exome-wide association study of pancreatic cancer risk. Gastroenterology, 154, pp. 719-722.e3. (doi: 10.1053/j.gastro.2017.10.015)

Wilson, R. A.M., Evans, T.R. J., Fraser, A. R., Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191, pp. 133-148. (doi: 10.1111/cei.13081)

Schofield, H. K., Zeller, J., Espinoza, C., Halbrook, C. J., Del Vecchio, A., Magnuson, B., Fabo, T., Daylan, A. E. C., Kovalenko, I., Lee, H.-J., Yan, W., Feng, Y., Karim, S. A., Kremer, D. M., Kumar-Sinha, C., Lyssiotis, C. A., Ljungman, M., Morton, J. P., Galbán, S., Fearon, E. R., Pasca di Magliano, M. (2018) Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight, 3, (doi: 10.1172/jci.insight.97422)

Campbell, K. J., Dhayade, S., Ferrari, N., Sims, A. H., Johnson, E., Mason, S. M., Dickson, A., Ryan, K. M., Kalna, G., Edwards, J., Tait, S. G.W., Blyth, K. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, (doi: 10.1038/s41419-017-0035-2)

Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D., Morrell, N. W. (2018) TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nature Communications, 8, (doi: 10.1038/ncomms14079)

Duarte, D., Hawkins, E. D., Akinduro, O., Ang, H., De Filippo, K., Kong, I. Y., Haltalli, M., Ruivo, N., Straszkowski, L., Vervoot, S. J., McLean, C., Weber, T. S., Korshed, R., Pirillo, C., Wei, A., Ramasamy, S. K., Kusumbe, A. P., Duffy, K., Adams, R. H., Purton, L. E., Carlin, L. M., Lo Celso, C. (2018) Inhibition of endosteal vascular niche remodeling rescues hematopoietic stem cell loss in AML. Cell Stem Cell, 22, pp. 64-77.e6. (doi: 10.1016/j.stem.2017.11.006)

Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J., Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13, (doi: 10.1371/journal.pone.0183585)

Dreyer, S.B., Jamieson, N.B., Upstill-Goddard, R., Bailey, P.J., McKay, C.J., Australian Pancreatic Cancer Genome Initiative, , Biankin, A.V., Chang, D.K. (2018) Defining the molecular pathology of pancreatic body and tail adenocarcinom. British Journal of Surgery, 105, pp. e183-e191. (doi: 10.1002/bjs.10772)

Ecker, B. L. et al. (2018) Pancreatogastrostomy vs. pancreatojejunostomy: a risk-stratified analysis of 5316 pancreatoduodenectomies. Journal of Gastrointestinal Surgery, 22, pp. 68-76. (doi: 10.1007/s11605-017-3547-2)

Cao, K., Tait, S. W.G. (2018) Apoptosis and cancer: force awakens, phantom menace, or both? Elsevier

Deretic, V. et al. (2018) Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 14, pp. 925-929. (doi: 10.1080/15548627.2018.1465784)

Giampazolias, E., Tait, S. W.G. (2018) Caspase-independent cell death: an anti-cancer double-whammy. Cell Cycle, 17, pp. 269-270. (doi: 10.1080/15384101.2017.1408229)

Ferro, R., Adamska, A., Lattanzio, R., Mavrommati, I., Edling, C.E., Arifin, S.A., Fyffe, C.A., Sala, G., Sacchetto, L., Chiorino, G., De Laurenzi, V., Piantelli, M., Sansom, O.J., Maffucci, T., Falasca, M. (2018) GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine. Oncogene, 37, pp. 6368-6382. (doi: 10.1038/s41388-018-0390-1)

Sierra Gonzalez, P., O'Prey, J., Cardaci, S., Barthet, V. J.A., Sakamaki, J.-i., Beaumatin, F., Roseweir, A., Gay, D. M., Mackay, G., Malviya, G., Kania, E., Ritchie, S., Baudot, A. D., Zunino, B., Mrowinska, A., Nixon, C., Ennis, D., Hoyle, A., Millan, D., Mcneish, I. A., Sansom, O. J., Edwards, J., Ryan, K. M. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi: 10.1038/s41586-018-0729-3)

Bennett, L., Howell, M., Memon, D., Smowton, C., Zhou, C., Miller, C. J. (2018) Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. Scientific Reports, 8, (doi: 10.1038/s41598-018-33276-3)

Shroff, R. T., Hendifar, A., McWilliams, R. R., Geva, R., Epelbaum, R., Rolfe, L., Goble, S., Lin, K. K., Biankin, A. V., Giordano, H., Vonderheide, R. H., Domchek, S. M. (2018) Rucaparib monotherapy in patients with pancreatic cancer and a known deleterious BRCA mutation. JCO Precision Oncology, 2, (doi: 10.1200/po.17.00316)

Burke, Z. D., Reed, K. R., Yeh, S.-W., Meniel, V., Sansom, O. J., Clarke, A. R., Tosh, D. (2018) Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway. Scientific Reports, 8, (doi: 10.1038/s41598-018-20888-y)

Unal, E. B., Kiel, C., Benisty, H., Campbell, A., Pickering, K., Blüthgen, N., Sansom, O. J., Serrano, L. (2018) Systems level expression correlation of Ras GTPase regulators. Cell Communication and Signaling, 16, (doi: 10.1186/s12964-018-0256-8)

Rumney, R. M.H., Coffelt, S. B., Neale, T. A., Dhayade, S., Tozer, G. M., Miller, G. (2017) PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development. PLoS ONE, 12, (doi: 10.1371/journal.pone.0188591)

Walton, J. B., Farquharson, M., Mason, S., Port, J., Kruspig, B., Dowson, S., Stevenson, D., Murphy, D., Matzuk, M., Kim, J., Coffelt, S., Blyth, K., Mcneish, I. A. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, (doi: 10.1038/s41598-017-17119-1)

Conway, J. R.W., Vennin, C., Cazet, A. S., Herrmann, D., Murphy, K. J., Warren, S. C., Wullkopf, L., Boulghourjian, A., Zaratzian, A., Da Silva, A. M., Pajic, M., Morton, J. P., Cox, T. R., Timpson, P. (2017) Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology. Scientific Reports, 7, (doi: 10.1038/s41598-017-17177-5)

Cooke, S. L., Ennis, D., Evers, L., Dowson, S., Chan, M. Y., Paul, J., Hirschowitz, L., Glasspool, R., Singh, N., Bell, S., Day, E. K., Kochman, A., Wilkinson, N., Beer, P., Martin, S., Millan, D. W., Biankin, A. V., McNeish, I. A. (2017) The driver mutational landscape of ovarian squamous cell carcinomas arising in mature cystic teratoma. Clinical Cancer Research, 23, pp. 7633-7640. (doi: 10.1158/1078-0432.CCR-17-1789)

Balachandran, V. P. et al. (2017) Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature, 551, pp. 512-516. (doi: 10.1038/nature24462)

Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, (doi: 10.1038/s41467-017-01967-6)

Sakamaki, J.-I., Long, J. S., New, M., Van Acker, T., Tooze, S. A., Ryan, K. M. (2017) Emerging roles of transcriptional programs in autophagy regulation. Transcription, 9, pp. 131-136. (doi: 10.1080/21541264.2017.1372045)

D'Costa, Z., Jones, K., Azad, A., van Stiphout, R., Lim, S. Y., Gomes, A. L., Kinchesh, P., Smart, S. C., Gillies McKenna, W., Buffa, F. M., Sansom, O. J., Muschel, R. J., O'Neill, E., Fokas, E. (2017) Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Research, 77, pp. 5952-5962. (doi: 10.1158/0008-5472.CAN-16-2833)

Scarpa, A. et al. (2017) Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 550, pp. 548. (doi: 10.1038/nature24026)

Loveridge, C. J., van ’t Hof, R. J., Charlesworth, G., King, A., Tan, E. H., Rose, L., Daroszewska, A., Prior, A., Ahmad, I., Welsh, M., Mui, E. J., Ford, C., Salji, M., Sansom, O., Blyth, K., Leung, H. Y. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, (doi: 10.1038/s41598-017-13346-8)

Nobis, M. et al. (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21, pp. 274-288. (doi: 10.1016/j.celrep.2017.09.022)

Phesse, T. J., Durban, V. M., Sansom, O. J. (2017) Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models. Carcinogenesis, 38, pp. 953-965. (doi: 10.1093/carcin/bgx080)

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L.H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J., Sansom, O. J. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24, pp. 1681-1693. (doi: 10.1038/cdd.2017.92)

Villa, E., Proïcs, E., Rubio-Patiño, C., Obba, S., Zunino, B., Bossowski, J. P., Rozier, R. M., Chiche, J., Mondragón, L., Riley, J. S., Marchetti, S., Verhoeyen, E., Tait, S. W.G., Ricci, J.-E. (2017) Parkin-independent mitophagy controls chemotherapeutic response in cancer cells. Cell Reports, 20, pp. 2846-2859. (doi: 10.1016/j.celrep.2017.08.087)

Chiu, A., Ayub, M., Dive, C., Brady, G., Miller, C. J., Hancock, J. (2017) twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis. Bioinformatics, 33, pp. 2743-2745. (doi: 10.1093/bioinformatics/btx308)

Chuvin, N. et al. (2017) Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS(G12D)-driven pancreatic tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 4, pp. 263-282. (doi: 10.1016/j.jcmgh.2017.05.005)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19, pp. 1116-1129. (doi: 10.1038/ncb3596)

Phillips, T. J. et al. (2017) Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Scientific Reports, 7, (doi: 10.1038/s41598-017-06300-1)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36, pp. 2373-2389. (doi: 10.15252/embj.201694912)

Raphael, B. J. et al. (2017) Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell, 32, pp. 185-203.e13. (doi: 10.1016/j.ccell.2017.07.007)

Carron, E. C., Homra, S., Rosenberg, J., Coffelt, S. B., Kittrell, F., Zhang, Y., Creighton, C. J., Fuqua, S. A., Medina, D., Machado, H. L. (2017) Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget, 8, pp. 50731-50746. (doi: 10.18632/oncotarget.14913)

Khandelwal, G., Girotti, M. R., Smowton, C., Taylor, S., Wirth, C., Dynowski, M., Frese, K. K., Brady, G., Dive, C., Marais, R., Miller, C. (2017) Next-generation sequencing analysis and algorithms for PDX and CDX models. Molecular Cancer Research, 15, pp. 1012-1016. (doi: 10.1158/1541-7786.MCR-16-0431)

Meyer, T., Fox, R., Ma, Y. T., Ross, P. J., James, M. W., Sturgess, R., Stubbs, C., Stocken, D. D., Wall, L., Watkinson, A., Hacking, N., Evans, T.R. J., Collins, P., Hubner, R. A., Cunningham, D., Primrose, J. N., Johnson, P. J., Palmer, D. H. (2017) Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial. Lancet Gastroenterology and Hepatology, 2, pp. 565-575. (doi: 10.1016/S2468-1253(17)30156-5)

Grose, D., McIntosh, D., Jamieson, N., Carter, R., Dickson, E., Chang, D., Marashi, H., Wilson, C., Alfayez, M., Kerr, A., O’Donoghue, R., Haskins, L., Duthie, F., McKay, C. J., Graham, J. (2017) The role of induction chemotherapy + chemoradiotherapy in localised pancreatic cancer: initial experience in Scotland. Journal of Gastrointestinal Oncology, 8, pp. 683-695. (doi: 10.21037/jgo.2017.04.01)

Harris, N.L.E., Vennin, C., Conway, J.R.W., Vine, K.L., Pinese, M., Cowley, M.J., Shearer, R.F., Lucas, M.C., Herrmann, D., Allam, A.H., Pajic, M., Morton, J., Biankin, A.V., Ranson, M., Timpson, P., Saunders, D.N. (2017) SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer. Oncogene, 36, pp. 4288-4298. (doi: 10.1038/onc.2017.63)

Tian, A., Benchabane, H., Wang, Z., Zimmerman, C., Xin, N., Perochon, J., Kalna, G., Sansom, O. J., Cheng, C., Cordero, J. B., Ahmed, Y. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13, (doi: 10.1371/journal.pgen.1006870)

Galluzzi, L. et al. (2017) Molecular definitions of autophagy and related processes. EMBO Journal, 36, pp. 1811-1836. (doi: 10.15252/embj.201796697)

Secklehner, J., Lo Celso, C., Carlin, L. M. (2017) Intravital microscopy in historic and contemporary immunology. Immunology and Cell Biology, 95, pp. 506-513. (doi: 10.1038/icb.2017.25)

Phesse, T. J., Sansom, O. J. (2017) Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology, 19, pp. 752-754. (doi: 10.1038/ncb3567)

Rice, A.J., Cortes, E., Lachowski, D., Cheung, B.C.H., Karim, S.A., Morton, J.P., Del Rio Hernandez, A. (2017) Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells. Oncogenesis, 6, (doi: 10.1038/oncsis.2017.54)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P., Sansom, O. J., Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24, pp. 1303-1304. (doi: 10.1038/cdd.2016.120)

de la Cruz-Merino, L., Di Guardo, L., Grob, J.-J., Venosa, A., Larkin, J., McArthur, G. A., Ribas, A., Acierto, P. A., Evans, J. T.R., Gomez‑Escobar, A., Barteselli, G., Eng, S., Hsu, J. J., Uyei, A., Dréno, B. (2017) Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study. Journal of Translational Medicine, 15, (doi: 10.1186/s12967-017-1246-0)

Loveridge, C. J., Mui, E. J., Patel, R., Tan, E. H., Ahmad, I., Welsh, M., Galbraith, J., Hedley, A., Nixon, C., Blyth, K., Sansom, O., Leung, H. Y. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77, pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565)

Feigin, M. E., Garvin, T., Bailey, P., Waddell, N., Chang, D. K., Kelley, D. R., Shuai, S., Gallinger, S., McPherson, J. D., Grimmond, S. M., Khurana, E., Stein, L. D., Biankin, A. V., Schatz, M. C., Tuveson, D. A. (2017) Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nature Genetics, 49, pp. 825-833. (doi: 10.1038/ng.3861)

Lachowski, D., Cortes, E., Pink, D., Chronopoulos, A., Karim, S. A., Morton, J. P., del Río Hernández, A. E. (2017) Substrate rigidity controls activation and durotaxis in pancreatic stellate cells. Scientific Reports, 7, (doi: 10.1038/s41598-017-02689-x)

Diamantopoulou, Z., White, G., Fadlullah, M. Z.H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. F.L., Malliri, A. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31, pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007)

McMillan, M. T. et al. (2017) Incorporation of procedure-specific risk into the ACS-NSQIP surgical risk calculator improves the prediction of morbidity and mortality after pancreatoduodenectomy. Annals of Surgery, 265, pp. 978-986. (doi: 10.1097/SLA.0000000000001796)

Karadjian, G., Fercoq, F., Pionnier, N., Vallarino-Lhermitte, N., Lefoulon, E., Nieguitsila, A., Specht, S., Carlin, L. M., Martin, C. (2017) Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. PLoS Neglected Tropical Diseases, 11, (doi: 10.1371/journal.pntd.0005596)

Dreyer, S. B., Powell, A. G.M.T., McSorley, S. T., Waterston, A., Going, J. J., Edwards, J., McMillan, D. C., Horgan, P. G. (2017) The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer. Annals of Surgical Oncology, 24, pp. 1295-1303. (doi: 10.1245/s10434-016-5684-3)

Zhang, Q., Kersemans, V., Beech, J. S., Gilchrist, S., Kinchesh, P., Allen, P. D., Thompson, J., Gomes, A. L., D’Costa, Z., Bird, L., Tullis, I. D.C., Newman, R. G., Corroyer-Dulmont, A., Falzone, N., Azad, A., Vallis, K. A., Sansom, O. J., Muschel, R. J., Vojnovic, B., Hill, M. A., Fokas, E., Smart, S. C. (2017) An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse. PLoS ONE, 12, (doi: 10.1371/journal.pone.0176693)

Johns, A. L. et al. (2017) Lost in translation: returning germline genetic results in genome-scale cancer research. Genome Medicine, 9, (doi: 10.1186/s13073-017-0430-4)

Maddocks, O. D.K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J.F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., Blagih, J., Vincent, D. F., Campbell, K. J., Ceteci, F., Sansom, O. J., Blyth, K., Vousden, K. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544, pp. 372-376. (doi: 10.1038/nature22056)

Jung, L.A., Gebhardt, A., Koelmel, W., Ade, C.P., Walz, S., Kuper, J., von Eyss, B., Letschert, S., Redel, C., d’Artista, L., Biankin, A., Zender, L., Sauer, M., Wolf, E., Evan, G., Kisker, C., Eilers, M. (2017) OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36, pp. 1911-1924. (doi: 10.1038/onc.2016.354)

Daniels, B. P., Snyder, A. G., Olsen, T. M., Orozco, S., Oguin III, T. H., Tait, S. W.G., Martinez, J., Gale, M., Loo, Y.-M., Oberst, A. (2017) RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation. Cell, 169, pp. 301-313.e11. (doi: 10.1016/j.cell.2017.03.011)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9, (doi: 10.1126/scitranslmed.aai8504)

Pishvaian, M. J., Biankin, A. V., Bailey, P., Chang, D. K., Laheru, D., Wolfgang, C. L., Brody, J. R. (2017) BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer. British Journal of Cancer, 116, pp. 1021-1026. (doi: 10.1038/bjc.2017.40)

Ichim, G., Tait, S. W.G. (2017) Cancer therapy-induced PAFR ligand expression: any role for caspase activity? Nature Reviews Cancer, 17, pp. 253. (doi: 10.1038/nrc.2017.16)

Dreyer, S. B., Chang, D. K., Bailey, P., Biankin, A. V. (2017) Pancreatic cancer genomes: implications for clinical management and therapeutic development. Clinical Cancer Research, 23, pp. 1638-1646. (doi: 10.1158/1078-0432.CCR-16-2411)

Wilson, R. H., Evans, T.R. J., Middleton, M. R., Molife, L. R., Spicer, J., Dieras, V., Roxburgh, P., Giordano, H., Jaw-Tsai, S., Goble, S., Plummer, R. (2017) A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours. British Journal of Cancer, 116, (doi: 10.1038/bjc.2017.36)

Gundry, C., Marco, S., Rainero, E., Miller, B., Dornier, E., Mitchell, L., Caswell, P. T., Campbell, A., Hogeweg, A., Sansom, O. J., Morton, J. P., Norman, J. C. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, (doi: 10.1038/ncomms14646)

Fumagalli, A., Drost, J., Suijkerbuijk, S. J.E., van Boxtel, R., de Ligt, J., Offerhaus, G. J., Begthel, H., Beerling, E., Tan, E. H., Sansom, O. J., Cuppen, E., Clevers, H., van Rheenen, J. (2017) Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E2357-E2364. (doi: 10.1073/pnas.1701219114)

Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W.G., Larue, L., Brakebusch, C. H., Insall, R. H., Machesky, L. M. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27, pp. 624-637. (doi: 10.1016/j.cub.2017.01.033)

Scarpa, A. et al. (2017) Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 543, pp. 65-71. (doi: 10.1038/nature21063)

Gutierrez, K. D., Davis, M. A., Daniels, B. P., Olsen, T. M., Ralli-Jain, P., Tait, S. W.G., Gale, Jr., M., Oberst, A. (2017) MLKL activation triggers NLRP3-mediated processing and release of IL-1β independently of gasdermin-D. Journal of Immunology, 198, pp. 2156-2164. (doi: 10.4049/jimmunol.1601757)

Jamieson, N.B., Maker, A.V. (2017) Gene-expression profiling to predict responsiveness to immunotherapy. Cancer Gene Therapy, 24, pp. 134-140. (doi: 10.1038/cgt.2016.63)

Irshad, S. et al. (2017) RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers. Cancer Research, 77, pp. 1083-1096. (doi: 10.1158/0008-5472.CAN-16-0598)

Simon, H.-U., Friis, R., Tait, S. W.G., Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10, (doi: 10.1126/scisignal.aag2791)

Biankin, A. V. (2017) The road to precision oncology. Nature Genetics, 49, pp. 320-321. (doi: 10.1038/ng.3796)

Vallejo, A., Perurena, N., Guruceaga, E., Mazur, P. K., Martinez-Canarias, S., Zandueta, C., Valencia, K., Arricibita, A., Gwinn, D., Sayles, L. C., Chuang, C.-H., Guembe, L., Bailey, P., Chang, D. K., Biankin, A., Ponz-Sarvise, M., Andersen, J. B., Khatri, P., Bozec, A., Sweet-Cordero, E. A., Sage, J., Lecanda, F., Vicent, S. (2017) An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nature Communications, 8, (doi: 10.1038/ncomms14294)

Myant, K. B., Cammareri, P., Hodder, M. C., Wills, J., Von Kriegsheim, A., Győrffy, B., Rashid, M., Polo, S., Maspero, E., Vaughan, L., Gurung, B., Barry, E., Malliri, A., Camargo, F., Adams, D. J., Iavarone, A., Lasorella, A., Sansom, O. J. (2017) HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. EMBO Molecular Medicine, 9, pp. 181-197. (doi: 10.15252/emmm.201606684)

Azad, A., Yin Lim, S., D'Costa, Z., Jones, K., Diana, A., Sansom, O. J., Kruger, P., Liu, S., McKenna, W. G., Dushek, O., Muschel, R. J., Fokas, E. (2017) PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Molecular Medicine, 9, pp. 167-180. (doi: 10.15252/emmm.201606674)

Rath, N., Morton, J. P., Julian, L., Helbig, L., Kadir, S., McGhee, E. J., Anderson, K. I., Kalna, G., Mullin, M., Pinho, A. V., Rooman, I., Samuel, M. S., Olson, M. F. (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9, pp. 198-218. (doi: 10.15252/emmm.201606743)

Smowton, C., Balla, A., Antoniades, D., Miller, C., Pallis, G., Dikaiakos, M. D., Xing, W. (2017) A cost-effective approach to improving performance of big genomic data analyses in clouds. Future Generation Computer Systems, 67, pp. 368-381. (doi: 10.1016/j.future.2015.11.011)

van Baal, J.O.A.M., Van de Vijver, K.K., Coffelt, S.B., van der Noort, V., van Driel, W.J., Kenter, G.G., Buist, M.R., Lok, C.A.R. (2017) Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 486-494. (doi: 10.1111/1471-0528.14425)

Evans, T.R.J., Van Cutsem, E., Moore, M.J., Bazin, I.S., Rosemurgy, A., Bodoky, G., Deplanque, G., Harrison, M., Melichar, B., Pezet, D., Elekes, A., Rock, E., Lin, C., Strauss, L., O'Dwyer, P.J. (2017) Phase 2 placebo-controlled, double-blind trial of dasatinib added to gemcitabine for patients with locally-advanced pancreatic cancer. Annals of Oncology, 28, pp. 354-361. (doi: 10.1093/annonc/mdw607)

Spender, L. C., Inman, G. J. (2017) Targeting BRAF-mutant tumours with TGFBR1 inhibitors. Aging, 9, pp. 5-6. (doi: 10.18632/aging.101169)

Hardie, R.-A., van Dam, E., Cowley, M., Han, T.-L., Balaban, S., Pajic, M., Pinese, M., Iconomou, M., Shearer, R. F., McKenna, J., Miller, D., Waddell, N., Pearson, J. V., Grimmond, S. M., Sazanov, L., Biankin, A. V., Villas-Boas, S., Hoy, A. J., Turner, N., Saunders, D. N. (2017) Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer and Metabolism, 5, (doi: 10.1186/s40170-017-0164-1)

Byrne, A. T. et al. (2017) Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nature Reviews Cancer, 17, pp. 254-268. (doi: 10.1038/nrc.2016.140)

van der Weyden, L., Arends, M. J., Campbell, A. D., Bald, T., Wardle-Jones, H., Griggs, N., Del Castillo Velasco-Herrera, M., Tüting, T., Sansom, O. J., Karp, N. A., Clare, S., Gleeson, D., Ryder, E., Galli, A., Tuck, E., Cambridge, E. L., Voet, T., Macaulay, I. C., Wong, K., Spiegel, S., Speak, A. O., Adams, D. J. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541, pp. 233-236. (doi: 10.1038/nature20792)

Jackstadt, R., Sansom, O. J. (2017) The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. EMBO Journal, 36, pp. 3-4. (doi: 10.15252/embj.201695973)

Morton, J. P., Sansom, O. J. (2017) CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy? Immunotherapy, 9, pp. 9-12. (doi: 10.2217/imt-2016-0115)

Correia-Melo, C., Ichim, G., Tait, S., Passos, J. F. (2017) Depletion of mitochondria in mammalian cells through enforced mitophagy. Nature Protocols, 12, pp. 183-194. (doi: 10.1038/nprot.2016.159)

Humphris, J. L. et al. (2017) Hypermutation in pancreatic cancer. Gastroenterology, 152, pp. 68-74.e2. (doi: 10.1053/j.gastro.2016.09.060)

Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., Keyes, W. M. (2017) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes and Development, 31, pp. 172-183. (doi: 10.1101/gad.290635.116)

Martinelli, P., Carrillo-de Santa Pau, E., Cox, T., Sainz, B., Dusetti, N., Greenhalf, W., Rinaldi, L., Costello, E., Ghaneh, P., Malats, N., Büchler, M., Pajic, M., Biankin, A. V., Iovanna, J., Neoptolemos, J., Real, F. X. (2017) GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer. Gut, 66, pp. 1665-1676. (doi: 10.1136/gutjnl-2015-311256)

Rose, A. M., Sansom, O. J., Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16, pp. 386-387. (doi: 10.1080/15384101.2016.1259892)

Kersten, K., Coffelt, S. B., Hoogstraat, M., Verstegen, N. J.M., Vrijland, K., Ciampricotti, M., Doornebal, C. W., Hau, C.-S., Wellenstein, M. D., Salvagno, C., Doshi, P., Lips, E. H., Wessels, L. F.A., de Visser, K. E. (2017) Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. OncoImmunology, 6, (doi: 10.1080/2162402X.2017.1334744)

Carter, L., Rothwell, D. G., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., Hodgkinson, C. L., Morris, K., Priest, L., Carter, M., Miller, C., Hughes, A., Blackhall, F., Dive, C., Brady, G. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23, pp. 114-119. (doi: 10.1038/nm.4239)

Draper, J. E., Sroczynska, P., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130, pp. 271-284. (doi: 10.1182/blood-2016-06-723635)

Weigert, M., Binks, A., Dowson, S., Leung, E. Y.L., Athineos, D., Yu, X., Mullin, M., Walton, J. B., Orange, C., Ennis, D., Blyth, K., Tait, S. W.G., McNeish, I. A. (2017) RIPK3 promotes adenovirus type 5 activity. Cell Death and Disease, 8, (doi: 10.1038/s41419-017-0110-8)

Wildenberg, M.E., Koelink, P.J., Diederen, K., te Velde, A.A., Wolfkamp, S.C.S., Nuij, V.J., Peppelenbosch, M.P., Nobis, M., Sansom, O.J., Anderson, K.I., van der Woude, C.J., D’Haens, G.R.A.M., van den Brink, G.R. (2017) The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunology, 10, pp. 352-360. (doi: 10.1038/mi.2016.65)

Sakamaki, J.-I., Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13, pp. 2006-2007. (doi: 10.1080/15548627.2017.1364822)

Soria, J.C., Gan, H.K., Blagden, S.P., Plummer, R., Arkenau, H.T., Ranson, M., Evans, T.R.J., Zalcman, G., Bahleda, R., Hollebecque, A., Lemech, C., Dean, E., Brown, J., Gibson, D., Peddareddigari, V., Murray, S., Nebot, N., Mazumdar, J., Swartz, L., Auger, K.R., Fleming, R.A., Singh, R., Millward, M. (2016) A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors. Annals of Oncology, 27, pp. 2268-2274. (doi: 10.1093/annonc/mdw427)

Pécot, J., Maillet, L., Le Pen, J., Vuillier, C., Trécesson, S. d. C., Fétiveau, A., Sarosiek, K. A., Bock, F. J., Braun, F., Letai, A., Tait, S. W.G., Gautier, F., Juin, P. P. (2016) Tight sequestration of BH3 proteins by BCL-xL at subcellular membranes contributes to apoptotic resistance. Cell Reports, 17, pp. 3347-3358. (doi: 10.1016/j.celrep.2016.11.064)

Sharbeen, G., Youkhana, J., Mawson, A., McCarroll, J., Nunez, A., Biankin, A., Johns, A., Goldstein, D., Phillips, P. (2016) MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity. Oncotarget, 8, pp. 9216-9229. (doi: 10.18632/oncotarget.13985)

Roy, N., Takeuchi, K. K., Ruggeri, J. M., Bailey, P., Chang, D., Li, J., Leonhardt, L., Puri, S., Hoffman, M. T., Gao, S., Halbrook, C. J., Song, Y., Ljungman, M., Malik, S., Wright, C. V.E., Dawson, D. W., Biankin, A. V., Hebrok, M., Crawford, H. C. (2016) PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes and Development, 30, pp. 2669-2683. (doi: 10.1101/gad.291021.116)

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Girotti, M. R., Sibbet, G., Higgs, E. B., Shuttleworth, M. K., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., Dijke, P. t., Marais, R., Inman, G. J. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget, 7, pp. 81995-82012. (doi: 10.18632/oncotarget.13226)

Sharbeen, G., McCarroll, J., Liu, J., Youkhana, J., Limbri, L.F., Biankin, A.V., Johns, A., Kavallaris, M., Goldstein, D., Phillips, P.A. (2016) Delineating the role of βIV-Tubulins in pancreatic cancer: βIVb-tubulin inhibition sensitizes pancreatic cancer cells to vinca alkaloids. Neoplasia, 18, pp. 753-764. (doi: 10.1016/j.neo.2016.10.011)

Driscoll, D. R., Karim, S. A., Sano, M., Gay, D. M., Jacob, W., Yu, J., Mizukami, Y., Gopinathan, A., Jodrell, D. I., Evans, T.R. J., Bardeesy, N., Hall, M. N., Quattrochi, B. J., Klimstra, D. S., Barry, S. T., Sansom, O. J., Lewis, B. C., Morton, J. P. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76, pp. 6911-6923. (doi: 10.1158/0008-5472.CAN-16-0810)

Bangi, E., Murgia, C., Teague, A. G.S., Sansom, O. J., Cagan, R. L. (2016) Functional exploration of colorectal cancer genomes using Drosophila. Nature Communications, 7, (doi: 10.1038/ncomms13615)

Edeline, J., Blanc, J.-F., Johnson, P., Campillo-Gimenez, B., Ross, P., Ma, Y. T., King, J., Hubner, R. A., Sumpter, K., Darby, S., Evans, J., Iwuji, C., Swinson, D., Collins, P., Patel, K., Muazzam, I., Palmer, D. H., Meyer, T. (2016) A multicenter comparison between Child Pugh and ALBI scores in patients treated with sorafenib for hepatocellular carcinoma. Liver International, 36, pp. 1821-1828. (doi: 10.1111/liv.13170)

Williamson, S. C. et al. (2016) Vasculogenic mimicry in small cell lung cancer. Nature Communications, 7, (doi: 10.1038/ncomms13322)

Jamieson, D., Griffin, M. J., Sludden, J., Drew, Y., Cresti, N., Swales, K., Merriman, M., Allen, R., Bevan, P., Buerkle, M., Mala, C., Coyle, V., Rodgers, L., Dean, E., Greystoke, A., Banerji, U., Wilson, R. H., Evans, T.R. J., Anthoney, A., Ranson, M., Boddy, A. V., Plummer, R. (2016) A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours. European Journal of Cancer, 68, pp. 1-10. (doi: 10.1016/j.ejca.2016.08.026)

Koppens, M. A.J., Bounova, G., Cornelissen-Steijger, P., de Vries, N., Sansom, O. J., Wessels, L. F.A., van Lohuizen, M. (2016) Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget, 7, pp. 69816-69828. (doi: 10.18632/oncotarget.12002)

Guest, R. V., Boulter, L., Dwyer, B. J., Kendall, T. J., Man, T.-Y., Minnis-Lyons, S. E., Lu, W.-Y., Robson, A. J., Gonzalez, S. F., Raven, A., Wojtacha, D., Morton, J. P., Komuta, M., Roskams, T., Wigmore, S. J., Sansom, O. J., Forbes, S. J. (2016) Notch3 drives development and progression of cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 12250-12255. (doi: 10.1073/pnas.1600067113)

Bailey, P., Chang, D. K., Forget, M.-A., San Lucas, F. A., Alvarez, H. A., Haymaker, C., Chattopadhyay, C., Kim, S.-H., Ekmekcioglu, S., Grimm, E. A., Biankin, A. V., Hwu, P., Maitra, A., Roszik, J. (2016) Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma. Scientific Reports, 6, (doi: 10.1038/srep35848)

Propper, D., Jones, K., Anthoney, D. A., Mansoor, W., Ford, D., Eatock, M., Agarwal, R., Inatani, M., Saito, M., Evans, T.R. J. (2016) Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma. BMC Cancer, 16, (doi: 10.1186/s12885-016-2828-6)

Zhu, A. X., Kang, Y.-K., Rosmorduc, O., Evans, T.R. J., Santoro, A., Ross, P., Gane, E., Vogel, A., Jeffers, M., Meinhardt, G., Peña, C. E.A. (2016) Biomarker analyses of clinical outcomes in patients with advanced hepatocellular carcinoma treated with Sorafenib with or without Erlotinib in the SEARCH Trial. Clinical Cancer Research, 22, pp. 4870-4879. (doi: 10.1158/1078-0432.CCR-15-2883)

Kumar, N., Srivillibhuthur, M., Joshi, S., Walton, K. D., Zhou, A., Faller, W. J., Perekatt, A. O., Sansom, O. J., Gumucio, D. L., Xing, J., Bonder, E. M., Gao, N., White, E., Verzi, M. P. (2016) A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development, 143, pp. 3711-3722. (doi: 10.1242/dev.137992)

Birch, J., Clarke, C., Campbell, A. D., Campbell, K., Mitchell, L., Liko, D., Kalna, G., Strathdee, D., Sansom, O. J., Neilson, M., Blyth, K., Norman, J. C. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5, pp. 1371-1379. (doi: 10.1242/bio.019075)

Aparicio, T., Zaanan, A., Mary, F., Afchain, P., Manfredi, S., Evans, T. R. J. (2016) Small bowel adenocarcinoma. Gastroenterology Clinics of North America, 45, pp. 447-457. (doi: 10.1016/j.gtc.2016.04.004)

Bilsland, A. E., Spiliopoulou, P., Evans, T.R. J. (2016) Virotherapy: cancer gene therapy at last? F1000Research, 5, (doi: 10.12688/f1000research.8211.1)

Cammareri, P. et al. (2016) Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications, 7, (doi: 10.1038/ncomms12493)

Lesina, M., Wörmann, S. M., Morton, J., Diakopoulos, K. N., Korneeva, O., Wimmer, M., Einwächter, H., Sperveslage, J., Demir, I. E., Kehl, T., Saur, D., Sipos, B., Heikenwälder, M., Steiner, J. M., Wang, T. C., Sansom, O. J., Schmid, R. M., Algül, H. (2016) RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. Journal of Clinical Investigation, 126, pp. 2919-2932. (doi: 10.1172/jci86477)

Ichim, G., Tait, S. W.G. (2016) A fate worse than death: apoptosis as an oncogenic process. Nature Reviews Cancer, 16, pp. 539-548. (doi: 10.1038/nrc.2016.58)

Swanton, C., Soria, J.-C., Bardelli, A., Biankin, A., Caldas, C., Chandarlapaty, S., de Koning, L., Dive, C., Feunteun, J., Leung, S.-Y., Marais, R., Mardis, E. R., McGranahan, N., Middleton, G., Quezada, S. A., Rodón, J., Rosenfeld, N., Sotiriou, C., André, F. (2016) Consensus on precision medicine for metastatic cancers: a report from the MAP conference. Annals of Oncology, 27, pp. 1443-1448. (doi: 10.1093/annonc/mdw192)

Humphrey, E. S., Su, S.-P., Nagrial, A. M., Hochgräfe, F., Pajic, M., Lehrbach, G. M., Parton, R. G., Yap, A. S., Horvath, L. G., Chang, D. K., Biankin, A. V., Wu, J., Daly, R. J. (2016) Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling. Molecular and Cellular Proteomics, 15, pp. 2671-2685. (doi: 10.1074/mcp.M116.058313)

Memon, D., Dawson, K., Smowton, C. S., Xing, W., Dive, C., Miller, C. J. (2016) Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response. npj Genomic Medicine, 1, (doi: 10.1038/npjgenmed.2016.20)

Sinclair, A., Park, L., Shah, M., Drotar, M., Calaminus, S., Hopcroft, L. E.M., Kinstrie, R., Guitart, A. V., Dunn, K., Abraham, S. A., Sansom, O., Michie, A. M., Machesky, L., Kranc, K. R., Graham, G. J., Pellicano, F., Holyoake, T. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128, pp. 371-383. (doi: 10.1182/blood-2015-08-661785)

Ahmad, I., Mui, E., Galbraith, L., Patel, R., Tan, E. H., Salji, M., Rust, A. G., Repiscak, P., Hedley, A., Markert, E., Loveridge, C., van der Weyden, L., Edwards, J., Sansom, O. J., Adams, D. J., Leung, H. Y. (2016) Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 8290-8295. (doi: 10.1073/pnas.1601571113)

Carter, L. R., Rothwell, D. G., Leong, H., Li, Y., Burt, D. J., Antonello, J., Hodgkinson, C., Morris, K., Franklin, L., Miller, C. J., Blackhall, F., Dive, C., Brady, G. (2016) Abstract 3155: Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells. (doi: 10.1158/1538-7445.AM2016-3155)

Gao, Y., Vincent, D., Davis, A. J., Sansom, O., Bartholin, L., Li, Q. (2016) Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. Oncotarget, 7, pp. 40904-40918. (doi: 10.18632/oncotarget.10149)

Wörmann, S. M., Song, L., Ai, J., Diakopoulos, K. N., Kurkowski, M. U., Görgülü, K., Ruess, D., Campbell, A., Doglioni, C., Jodrell, D., Neesse, A., Demir, I. E., Karpathaki, A.-P., Barenboim, M., Hagemann, T., Rose-John, S., Sansom, O., Schmid, R. M., Protti, M. P., Lesina, M., Algül, H. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151, pp. 180-193.e12. (doi: 10.1053/j.gastro.2016.03.010)

Riley, J. S., Tait, S. W.G. (2016) Mechanisms of mitophagy: putting the powerhouse into the doghouse. Biological Chemistry, 397, pp. 617-635. (doi: 10.1515/hsz-2016-0137)

Coffelt, S. B., Wellenstein, M. D., de Visser, K. E. (2016) Neutrophils in cancer: neutral no more. Nature Reviews Cancer, 16, pp. 431-446. (doi: 10.1038/nrc.2016.52)

Antonia, S. J., López-Martin, J. A., Bendell, J., Ott, P. A., Taylor, M., Eder, J. P., Jäger, D., Pietanza, M. C., Le, D. T., de Braud, F., Morse, M. A., Ascierto, P. A., Horn, L., Amin, A., Pillai, R. N., Evans, J., Chau, I., Bono, P., Atmaca, A., Sharma, P., Harbison, C. T., Lin, C.-S., Christensen, O., Calvo, E. (2016) Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial. Lancet Oncology, 17, pp. 883-895. (doi: 10.1016/S1470-2045(16)30098-5)

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29, pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014)

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K., Ryan, K., Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15, pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166)

Milojkovic Kerklaan, B., Slater, S., Flynn, M., Greystoke, A., Witteveen, P. O., Megui-Roelvink, M., de Vos, F., Dean, E., Reyderman, L., Ottesen, L., Ranson, M., Lolkema, M. P. J., Plummer, R., Kristeleit, R., Evans, T. R. J., Schellens, J. H. M. (2016) A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of α2 integrin inhibitor E7820 in patients with advanced solid tumors. Investigational New Drugs, 34, pp. 329-337. (doi: 10.1007/s10637-016-0344-9)

Morrow, C.J., Trapani, F., Metcalf, R.L., Bertolini, G., Hodgkinson, C.L., Khandelwal, G., Kelly, P., Galvin, M., Carter, L., Simpson, K.L., Williamson, S., Wirth, C., Simms, N., Frankliln, L., Frese, K.K., Rothwell, D.G., Nonaka, D., Miller, C.J., Brady, G., Blackhall, F.H., Dive, C. (2016) Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Annals of Oncology, 27, pp. 1155-1160. (doi: 10.1093/annonc/mdw122)

Languino, L. R., Singh, A., Prisco, M., Inman, G. J., Luginbuhl, A., Curry, J. M., South, A. P. (2016) Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma. American Journal of Translational Research, 8, pp. 2432-2437.

Tape, C. J., Ling, S., Dimitriadi, M., McMahon, K. M., Worboys, J. D., Leong, H. S., Norrie, I. C., Miller, C., Poulogiannis, G., Lauffenburger, D. A., Jørgensen, C. (2016) Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 165, pp. 910-920. (doi: 10.1016/j.cell.2016.03.029)

Jabbar, S.A.A., Jamieson, N.B., Morris, A.J., Oien, K.A., Duthie, F., McKay, C.J., Carter, C.R., Dickson, E.J. (2016) A Glasgow tipple-transjugular intrahepatic portosystemic shunt insertion prior to Whipple resection. Journal of Surgical Case Reports, 2016, (doi: 10.1093/jscr/rjw089)

Sakamaki, J.-i., Ryan, K. M. (2016) Autophagy determines the path on the TRAIL to death. Developmental Cell, 37, pp. 291-293. (doi: 10.1016/j.devcel.2016.05.010)

Chen, Y., Awan, N., Haveman, J. W., Apostolou, C., Chang, D. K., Merrett, N. D. (2016) Gastric cancer: Australian outcomes of multi-modality treatment with curative intent. ANZ Journal of Surgery, 86, pp. 386-390. (doi: 10.1111/ans.12693)

Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., Neoptolemos, J. P. (2016) Pancreatic cancer. Nature Reviews Disease Primers, 2, (doi: 10.1038/nrdp.2016.22)

Coffelt, S. B., de Visser, K. E. (2016) Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor. Immunity, 44, pp. 722-724. (doi: 10.1016/j.immuni.2016.03.014)

Rothwell, D. G., Smith, N., Morris, D., Leong, H. S., Li, Y., Hollebecque, A., Ayub, M., Carter, L., Antonello, J., Franklin, L., Miller, C., Blackhall, F., Dive, C., Brady, G. (2016) Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample. Molecular Oncology, 10, pp. 566-574. (doi: 10.1016/j.molonc.2015.11.006)

Correia-Melo, C. et al. (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal, 35, pp. 724-742. (doi: 10.15252/embj.201592862)

Palani Velu, L.K., McKay, C.J., Carter, C.R., McMillan, D.C., Jamieson, N.B., Dickson, E.J. (2016) Serum amylase and C-reactive protein in risk stratification of pancreas-specific complications after pancreaticoduodenectomy. British Journal of Surgery, 103, pp. 553-563. (doi: 10.1002/bjs.10098)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26, pp. 755-765. (doi: 10.1016/j.cub.2016.01.045)

Graham, J.S., Boyd, K., Coxon, F.Y., Wall, L.R., Eatock, M.M., Maughan, T.S., Highley, M., Soulis, E., Conway, F., Evans, T. (2016) A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract. BMC Research Notes, 9, (doi: 10.1186/s13104-015-1778-4)

Bailey, P. et al. (2016) Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 531, pp. 47-52. (doi: 10.1038/nature16965)

Giampazolias, E., Tait, S. W.G. (2016) Mitochondria and the hallmarks of cancer. FEBS Journal, 283, pp. 803-814. (doi: 10.1111/febs.13603)

Gingras, M.-C. et al. (2016) Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation. Cell Reports, 14, pp. 907-919. (doi: 10.1016/j.celrep.2015.12.005)

Matzke-Ogi, A., Jannasch, K., Shatirishvili, M., Fuchs, B., Chiblak, S., Morton, J., Tawk, B., Lindner, T., Sansom, O., Alves, F., Warth, A., Schwager, C., Mier, W., Kleeff, J., Ponta, H., Abdollahi, A., Orian-Rousseau, V. (2016) Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling. Gastroenterology, 150, pp. 513-525.e10. (doi: 10.1053/j.gastro.2015.10.020)

Lopez, J., Bessou, M., Riley, J. S., Giampazolias, E., Todt, F., Rochegüe, T., Oberst, A., Green, D. R., Edlich, F., Ichim, G., Tait, S. W.G. (2016) Mito-priming as a method of engineered Bcl-2 addiction. Nature Communications, 7, (doi: 10.1038/ncomms10538)

Marusiak, A. A., Stephenson, N. L., Baik, H., Trotter, E. W., Li, Y., Blyth, K., Mason, S., Chapman, P., Puto, L. A., Read, J. A., Brassington, C., Pollard, H. K., Phillips, C., Green, I., Overman, R., Collier, M., Testoni, E., Miller, C.J., Hunter, T., Sansom, O.J., Brognard, J. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76, pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t)

Grimes, H. L., Draper, J. E., Sroczynska, P., Tsoulaki, O., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2016) RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis. PLoS Genetics, 12, (doi: 10.1371/journal.pgen.1005814)

Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14, pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020)

Cheung, E., Lee, P., Ceteci, F., Nixon, C., Blyth, K., Sansom, O., Vousden, K. (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes and Development, 30, pp. 52-63. (doi: 10.1101/gad.271130.115)

Jackstadt, R., Sansom, O. (2016) Mouse models of intestinal cancer. Journal of Pathology, 238, pp. 141-151. (doi: 10.1002/path.4645)

Mrschtik, M., Ryan, K. M. (2016) Another DRAM involved in autophagy and cell death. Autophagy, 12, pp. 603-605. (doi: 10.1080/15548627.2015.1137412)

Gillespie, D. A., Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3, (doi: 10.1080/23723556.2015.1030538)

Humphris, J. L., Biankin, A. V. (2016) Diagnosis and management of hereditary pancreatic cancer. Springer International Publishing

Spender, L.C., Inman, G.J. (2016) Fatal attractions? Correlations of CXCL12-CXCR4-CXCR7 expression with disease progression in melanoma and Kaposi sarcoma. British Journal of Dermatology, 175, pp. 1140-1141. (doi: 10.1111/bjd.15136)

Thambyrajah, R., Mazan, M., Patel, R., Moignard, V., Stefanska, M., Marinopoulou, E., Li, Y., Lancrin, C., Clapes, T., Möröy, T., Robin, C., Miller, C., Cowley, S., Göttgens, B., Kouskoff, V., Lacaud, G. (2016) GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology, 18, pp. 21-32. (doi: 10.1038/ncb3276)

Klionsky, D. J. et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy, 12, pp. 1-222. (doi: 10.1080/15548627.2015.1100356)

Elbediwy, A., Vincent-Mistiaen, Z. I., Spencer-Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J., Tan, E. H., Ridgway, R., Brunton, V. G., Sahai, E., Gerhardt, H., Behrens, A., Malanchi, I., Sansom, O. J., Thompson, B. J. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143, pp. 1674-1687. (doi: 10.1242/dev.133728)

Ali, A., Bell, S., Bilsland, A., Slavin, J., Lynch, V., Elgoweini, M., Derakhshan, M. H., Jamieson, N. B., Chang, D., Brown, V., Denley, S., Orange, C., McKay, C., Carter, R., Oien, K. A., Duthie, F. R. (2016) Investigating various thresholds as immunohistochemistry cutoffs for observer agreement. Applied Immunohistochemistry and Molecular Morphology, 25, pp. 599-608. (doi: 10.1097/PAI.0000000000000357)

Rahat, M. A., Coffelt, S., Granot, Z., Muthana, M., Amedei, A. (2016) Macrophages and neutrophils: regulation of the inflammatory microenvironment in autoimmunity and cancer. Mediators of Inflammation, 2016, (doi: 10.1155/2016/5894347)

Oberst, A., Ichim, G., Tait, S. W.G. (2016) Mitochondrial permeabilization: from lethality to vitality. Springer

Coffelt, S. B., de Visser, K. E. (2016) Systemic inflammation: Cancer's long-distance reach to maximize metastasis. OncoImmunology, 5, (doi: 10.1080/2162402X.2015.1075694)

Harwood, C. A., Proby, C. M., Inman, G. J., Leigh, I. M. (2016) The promise of genomics and the development of targeted therapies for cutaneous squamous cell carcinoma. Acta Dermato Venereologica, 96, pp. 3-16. (doi: 10.2340/00015555-2181)

Carotenuto, P. et al. (2016) Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut, 66, pp. 1268-1277. (doi: 10.1136/gutjnl-2016-312278)

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P., Ryan, K. M. (2016) p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death. Cell Cycle, 15, pp. 2299-2308. (doi: 10.1080/15384101.2016.1191714)