Mesothelioma

Mesothelioma numbers in Scotland are amongst the highest in the world – a direct consequence of asbestos utilisation in heavy industries and construction over prior decades. Research aspirations in SCS are focussed on improving outcomes for mesothelioma patients.

Staff

Publications

2025

Cartwright, D., Kidd, A. C., Ansel, S., Ascierto, M. L., Spiliopoulou, P. (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences,

Farndale, L., Insall, R., Yuan, K. (2025) TriDeNT: Triple deep network training for privileged knowledge distillation in histopathology. Medical Image Analysis, 102, (doi: 10.1016/j.media.2025.103479)

Ji, Y., Cutiongco, M. F.A., Jensen, B. S., Yuan, K. (2025) Generating realistic single-cell images from CellProfiler representations. Medical Image Analysis, (doi: 10.1016/j.media.2025.103574)

Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z)

Coudray, N. et al. (2025) Self supervised artificial intelligence predicts poor outcome from primary cutaneous squamous cell carcinoma at diagnosis. npj Digital Medicine, 8, (doi: 10.1038/s41746-025-01496-3)

Alkarn, A., Stapleton, L. J., Eleftheriou, D., Stewart, L., Chalmers, G., Hamed, A., Hussein, K., Blyth, K. G., van der Hors, J. C., Maclay, J. D. (2025) Real life pre-operative nodal staging accuracy in non-small cell lung cancer and its relationship with survival. Diagnostics, 15, (doi: 10.3390/diagnostics15040430)

Lytras, S., Lamb, K. D., Ito, J., Grove, J., Yuan, K., Sato, K., Hughes, J., Robertson, D. L. (2025) Pathogen genomic surveillance and the AI revolution. Journal of Virology, 99, (doi: 10.1128/jvi.01601-24)

Iwata, T., Ammar, A., Maka, N., Jawny, J., Hay, J., Martinelli, S., Officer-Jones, L., Le Quesne, J., Lynch, G., McSorley, S., Edwards, J. (2025) Does Immune Suppression in the Pre-malignant Microenvironment of Colorectal Neoplastic Lesions Associate with Development of Metachronous Polyp and Cancer Risk?

Coudray, N., Occidental, M. A., Mantilla, J. G., Claudio Quiros, A., Yuan, K., Balko, J., Tsirigos, A., Jour, G. (2025) Quantitative and morphology-based deep convolutional neural network approaches for osteosarcoma survival prediction in the neoadjuvant and metastatic settings. Clinical Cancer Research, 31, pp. 365-375. (doi: 10.1158/1078-0432.ccr-24-2599)

Neilly, M. D.J., Dick, C., Blyth, K. G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14, (doi: 10.1007/s13665-025-00371-6)

2024

Seyedshahi, F., Rakovic, K., Poulain, N., Claudio Quiros, A., Powley, I. R., Richards, C., Uraiby, H., Klebe, S., Nakas, A., Wilson, C., Sereno, M., Officer-Jones, L., Ficken, C., Teodosio, A., Ballantyne, F., Murphy, D., Yuan, K., Le Quesne, J. (2024) A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images. bioRxiv, (doi: 10.1101/2024.11.18.624103)

Williamson, A., Houston, P., Paterson, J., Chalmers, A. J., McLoone, P., Fullerton, N., Foo, S. Y., James, A., Nowicki, S. (2024) Dosimetric comparison of hippocampal sparing technologies in patients with low grade glioma. Neuro-Oncology Advances, 6, (doi: 10.1093/noajnl/vdae131)

Liu, D., Young, F., Lamb, K. D., Claudio Quiros, A., Pancheva, A., Miller, C., Macdonald, C., Robertson, D. L., Yuan, K. (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)

Liu, D., Young, F., Lamb, K. D., Robertson, D. L., Yuan, K. (2024) Prediction of virus-host associations using protein language models and multiple instance learning. PLoS Computational Biology, 20, (doi: 10.1371/journal.pcbi.1012597)

Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)

Lamb, K. D., Hughes, J., Lytras, S., Young, F., Koci, O., Herzig, J., Lovell, S. C.,, Grove, J., Yuan, K., Robertson, D. L. (2024) From a single sequence to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 protein sequences. bioRxiv, (doi: 10.1101/2024.07.05.602129)

Churchhouse, A. M.D., Billard, C. V., Suzuki, T., Pohl, S. O.G., Donnelly, K., Nixon, C., Arends, M. J., Din, S., Kirkwood, K., Marques Junior, J., Von Kriegsheim, A., Coffelt, S. B., Myant, K. B. (2024) Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression. Oncogene, 43, pp. 3094-3107. (doi: 10.1038/s41388-024-03135-9)

Jackson, M. R., Richards, A. R., Oladipupo, A.-B. A., Chahal, S. K., Caragher, S., Chalmers, A. J., Gomez-Roman, N. (2024) ClonoScreen3D - a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma. International Journal of Radiation Oncology, Biology, Physics, 120, pp. 162-177. (doi: 10.1016/j.ijrobp.2024.02.046)

Lorimer, C., Mills, S., Chalmers, A., Coombes, I., Thompson, G., Glendenning, J., Radon, M., Jones, C., Williamson, A., Brock, J. (2024) Baseline total brain volume predicts changes in quality of life and overall survival after cranial radiotherapy in older patients with glioblastoma: Results from the prospective BRITER study. Neuro-Oncology Practice, 11, pp. 413-420. (doi: 10.1093/nop/npae019)

Boele, F., Rosenlund, L., Nordentoft, S., Melhuish, S., Nicklin, E., Rydén, I., Williamson, A., Donders-Kamphuis, M., Preusser, M., Le Rhun, E., Kiesel, B., Minniti, G., Furtner, J., Dirven, L., Taphoorn, M., Galldiks, N., Rudà, R., Chalmers, A., Short, S. C., Piil, K., the Nurse and Allied Health Professionals Committee, , the Disparity and Inclusion Committee of EANO, (2024) Inequalities in access to neuro-oncology supportive care and rehabilitation: a survey of healthcare professionals’ perspectives. Neuro-Oncology Practice, 11, pp. 484-493. (doi: 10.1093/nop/npae023)

Frankell, A. M. et al. (2024) Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631, (doi: 10.1038/s41586-024-07738-w)

Werner, J.-M., Petrescu, G. E.D., Boele, F., Preusser, M., Platten, M., Chalmers, A. J., Short, S. C., Piil, K. (2024) Chairing scientific sessions at international Neuro-Oncology meetings: an EANO guide for early-career professionals. Neuro-Oncology Practice, (doi: 10.1093/nop/npae060)

Vincelette, N. D. et al. (2024) Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis. Blood Cancer Discovery, 5, pp. 276-297. (doi: 10.1158/2643-3230.BCD-23-0210)

Skalka, G. L., Whyte, D., Lubawska, D., Murphy, D. J. (2024) NUAK: never underestimate a kinase. Essays In Biochemistry, (doi: 10.1042/EBC20240005)

Quiros, A. C., Coudray, N., Yeaton, A., Yang, X., Liu, B., Le, H., Chiriboga, L., Karimkhan, A., Narula, N., Moore, D. A., Park, C. Y., Pass, H., Moreira, A. L., Le Quesne, J., Tsirigos, A., Yuan, K. (2024) Mapping the landscape of histomorphological cancer phenotypes using self-supervised learning on unannotated pathology slides. Nature Communications, 15, (doi: 10.1038/s41467-024-48666-7)

Kumar, S., Basto, A. P., Ribeiro, F., Almeida, S. C.P., Campos, P., Peres, C., Pulvirenti, N., Al-Khalidi, S., Kilbey, A., Tosello, J., Piaggio, E., Russo, M., Gama-Carvalho, M., Coffelt, S. B., Roberts, E. W., Geginat, J., Florindo, H. F., Graca, L. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, (doi: 10.1038/s41421-024-00681-0)

Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, (doi: 10.1038/s41588-024-01809-4)

Blyth, K. G., Adusumilli, P. S., Astoul, P., Darlison, L., Lee, Y.C. G., Mansfield, A. S., Marciniak, S. J., Maskell, N., Panou, V., Peikert, T., Rahman, N. M., Zauderer, M. G., Sterman, D., Fennell, D. A. (2024) Leveraging the pleural space for anticancer therapies in pleural mesothelioma. Lancet Respiratory Medicine, 12, pp. 476-483. (doi: 10.1016/S2213-2600(24)00111-5)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1)

Sumaria, N., Fiala, G. J., Inácio, D., Curado-Avelar, M., Cachucho, A., Pinheiro, R., Wiesheu, R., Kimura, S., Courtois, L., Blankenhaus, B., Darrigues, J., Suske, T., Almeida, A. R. M., Minguet, S., Asnafi, V., Lhermitte, L., Mullighan, C. G., Coffelt, S. B., Moriggl, R., Barata, J. T., Pennington, D. J., Silva-Santos, B. (2024) Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms. Nature Immunology, (doi: 10.1038/s41590-024-01855-4)

Neilly, M., Ferguson, K., Roche, J., Tate, M., Blyth, K. (2024) Mesothelioma Evolution following a Diagnosis of Benign Pleural Inflammation: A Systematic Review and Meta-Analysis. (doi: 10.1016/j.lungcan.2024.107626)

Murphy, D. J. (2024) Investigating lung cancer using genetically engineered mouse models (GEMMS) Open Access Government, 42, pp. 112-113. (doi: 10.56367/oag-042-11090)

Lupo, F., Coffelt, S. B. (2024) Stressed out neutrophils drive metastasis. Immunity, 57, pp. 840-842. (doi: 10.1016/j.immuni.2024.03.013)

Derby, S., Jackson, M. R., Williams, K., Stobo, J., Kelly, C., Sweeting, L., Shad, S., Herbert, C., Short, S. C., Williamson, A., James, A., Nowicki, S., Bulbeck, H., Chalmers, A. (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118, pp. 1371-1378. (doi: 10.1016/j.ijrobp.2024.01.011)

Wakeham, K., Cooper, T., Rowbottom, C., Chalmers, A. J., Price, P., Quinlan, S., Spencer, K. (2024) Towards world-class radiotherapy in the UK: time for transformation. Lancet Oncology, 25, pp. 418-419. (doi: 10.1016/S1470-2045(24)00103-7)

Derby, S., Jackson, M. R., Williams, K., Stobo, J., Kelly, C., Sweeting, L., Shad, S., Herbert, C., Short, S. C., Williamson, A., James, A., Nowicki, S., Bulbeck, H., Chalmers, A. J. (2024) Concurrent olaparib and radiation therapy in older patients with newly diagnosed glioblastoma: the phase 1 dose-escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118, pp. 1371-1378. (doi: 10.1016/j.ijrobp.2024.01.011)

Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J., Sansom, O. J., O'Neill, E., Jones, K., Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050463)

Hassan, M., Touman, A. A., Grabczak, E. M., Skaarup, S. H., Faber, K., Blyth, K. G., Pochepnia, S. (2024) Imaging of pleural disease. Breathe, 20, (doi: 10.1183/20734735.0172-2023)

Liu, B., Polack, M., Coudray, N., Quiros, A. C., Sakellaropoulos, T., Crobach, A. S.L.P., van Krieken, J. H. J.M., Yuan, K., Tollenaar, R. A.E.M., Mesker, W. E., Tsirigos, A. (2024) Self-supervised learning reveals clinically relevant histomorphological patterns for therapeutic strategies in colon cancer. bioRxiv, (doi: 10.1101/2024.02.26.582106)

Tárnoki, Á. D., Tárnoki, D. L., Dąbrowska, M., Knetki-Wróblewska, M., Frille, A., Stubbs, H., Blyth, K. G., Juul, A. D. (2024) New developments in the imaging of lung cancer. Breathe, 20, (doi: 10.1183/20734735.0176-2023)

Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, pp. 458-472. (doi: 10.1038/s41588-024-01654-5)

Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, (doi: 10.1038/s43856-024-00455-5)

Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S., Tait, S. W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43, pp. 904-930. (doi: 10.1038/s44318-024-00044-1)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, (doi: 10.1038/s41467-024-45471-0)

Skalka, G. L., Tsakovska, M., Murphy, D. (2024) Kinase signaling adaptation supports dysfunctional mitochondria in disease. Frontiers in Molecular Biosciences, 11, (doi: 10.3389/fmolb.2024.1354682)

Lamb, K. D., Luka, M. M., Saathoff, M., Orton, R. J., Phan, M. V.T., Cotten, M., Yuan, K., Robertson, D. L. (2024) Mutational signature dynamics indicate SARS-CoV-2's evolutionary capacity is driven by host antiviral molecules. PLoS Computational Biology, 20, (doi: 10.1371/journal.pcbi.1011795)

Catarata, M. J., Creamer, A. W., Dias, M., Toland, S., Chaabouni, M., Verbeke, K., Vieira Naia, J., Hassan, M., Naidu, S. B., Lynch, G. A., Blyth, K. G., Rahman, N. M., Hardavella, G. (2024) ERS International Congress 2023: highlights from the Thoracic Oncology Assembly. ERJ Open Research, 10, (doi: 10.1183/23120541.00860-2023)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210)

Kidd, A. C., Cowell, G. W., Martin, G. A., Ferguson, J., Fennell, D. A., Evison, M., Blyth, K. G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42, (doi: 10.1016/j.ctarc.2024.100856)

2023

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7, pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Ferguson, J., Tsim, S., Kelly, C., Alexander, L., Shad, S., Neilly, M., Tate, M., Zahra, B., Saleh, M., Cowell, G., Banks, E., Grundy, S., Corcoran, J., Downer, N., Stanton, A., Evison, M., Rahman, N., Maskell, N., Blyth, K. (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10, (doi: 10.1136/bmjresp-2023-001771)

Zarou, M. M., Dawson, A., Prasad, B., Bittencourt-Silvestre, J., Zerbst, D., Rodriguez Blanco, G., Scott, M., Dunn, K., Krishnan, V., Copland, M., Vetrie, D., Bhatia, R., Coffelt, S., Ong, S. T., Wheadon, H., Zanivan, S., Kirschner, K., Helgason, G. V. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. (doi: 10.1182/blood-2023-181630)

Nikolatou, K., Sandilands, E., Román-Fernández, A., Cumming, E. M., Freckmann, E., Lilla, S., Buetow, L., McGarry, L., Neilson, M., Shaw, R., Strachan, D., Miller, C., Huang, D. T., Mcneish, I. A., Norman, J. C., Zanivan, S., Bryant, D. M. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, (doi: 10.15252/embj.2023113987)

Kouli, O. O., McLoone, P., Morrison, D., Zaorsky, N. G., Chalmers, A. J. (2023) Risk of stroke-specific mortality after radiotherapy in patients with primary brain tumours. Clinical and Translational Radiation Oncology, 42, (doi: 10.1016/j.ctro.2023.100658)

Quintana, J. F., Sinton, M. C., Chandrasegaran, P., Lestari, A. N., Heslop, R., Cheaib, B., Ogunsola, J., Ngoyi, D. M., Swar, N.-R. K., Cooper, A., Mabbott, N. A., Coffelt, S. B., MacLeod, A. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, (doi: 10.1038/s41467-023-40962-y)

Ferguson, K., Neilson, M., Mercer, R., King, J., Marshall, K., Welch, H., Tsim, S., Rahman, N. M., Maskell, N. A., Evison, M., Blyth, K. G. (2023) Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance. BMJ Open, 13, (doi: 10.1136/bmjopen-2022-067780)

Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11, pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644)

Ji, Y., Cutiongco, M. F.A., Jensen, B. S., Yuan, K. (2023) CP2Image: Generating High-Quality Single-Cell Images Using CellProfiler Representations.

Whyte, D., Skalka, G., Walsh, P., Wilczynska, A., Paul, N. R., Mitchel, C., Nixon, C., Clarke, W., Bushell, M., Morton, J. P., Murphy, D. J., Muthalagu, N. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, 17, pp. 1212-1227. (doi: 10.1002/1878-0261.13425)

Farahmand, P., Gyuraszova, K., Rooney, C., Raffo-Iraolagoitia, X. L., Jayasekera, G., Hedley, A., Johnson, E., Chernova, T., Malviya, G., Hall, H., Monteverde, T., Blyth, K., Duffin, R., Carlin, L. M., Lewis, D., le Quesne, J., MacFarlane, M., Murphy, D. J. (2023) Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Frontiers in Toxicology, 5, (doi: 10.3389/ftox.2023.1200650)

Hatthakarnkul, P., Ammar, A., Pennel, K. A.F., Officer-Jones, L., Cusumano, S., Quinn, J. A., Matly, A. A. M., Alexander, P. G., Hay, J., Andersen, D., Lynch, G., Van Wyk, H. C., Maka, N., McMillan, D. C., Le Quesne, J., Thuwajit, C., Edwards, J. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14, pp. 1837-1847. (doi: 10.7150/jca.83910)

Zhang, H., AbdulJabbar, K., Moore, D. A., Akarca, A., Enfield, K., Jamal-Hanjani, M., Raza, S. E. A., Veeriah, S., Salgado, R., McGranahan, N., Le Quesne, J., Swanton, C., Marafioti, T., Yuan, Y. (2023) Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma. Cancer Research, 83, pp. 1410-1425. (doi: 10.1158/0008-5472.CAN-22-2589)

May, S., Muller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Voorde, J. V., Officer-Jones, L., Ballantyne, F., Powley, I. R., Drake, T. M., Kiourtis, C., Keith, A., Rocha, A. S., Tardito, S., Sumpton, D., Le Quesne, J., Bushell, M., Sansom, O. J., Bird, T. G. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78, pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009)

Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30, pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w)

Ng, K. W. et al. (2023) Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature, 616, pp. 563-573. (doi: 10.1038/s41586-023-05771-9)

Martínez-Ruiz, C. et al. (2023) Genomic–transcriptomic evolution in lung cancer and metastasis. Nature, 616, pp. 543-552. (doi: 10.1038/s41586-023-05706-4)

Frankell, A. M. et al. (2023) The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 616, pp. 525-533. (doi: 10.1038/s41586-023-05783-5)

Al Bakir, M. et al. (2023) The evolution of non-small cell lung cancer metastases in TRACERx. Nature, 616, pp. 534-542. (doi: 10.1038/s41586-023-05729-x)

Abbosh, C. et al. (2023) Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature, 616, pp. 553-562. (doi: 10.1038/s41586-023-05776-4)

Hill, W. et al. (2023) Lung adenocarcinoma promotion by air pollutants. Nature, 616, pp. 159-167. (doi: 10.1038/s41586-023-05874-3)

Al-Sawaf, O. et al. (2023) Body composition and lung cancer-associated cachexia in TRACERx. Nature Medicine, 29, pp. 846-858. (doi: 10.1038/s41591-023-02232-8)

Karasaki, T. et al. (2023) Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature Medicine, 29, pp. 833-845. (doi: 10.1038/s41591-023-02230-w)

Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H.J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C.G.G., Staut, N., Subiel, A., Vaes, R. D.W., van Hoof, S. J., Verginadis, I. L., Wilkens, J. J., Williams, K. J., Wilson, G. D., Dubois, L. J. (2023) Roadmap for precision preclinical x-ray radiation studies. Physics in Medicine and Biology, 68, (doi: 10.1088/1361-6560/acaf45)

Coffelt, S. B., Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4, pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Katz, S. I., Straus, C. M., Roshkovan, L., Blyth, K. G., Frauenfelder, T., Gill, R. R., Lalezari, F., Erasmus, J., Nowak, A. K., Gerbaudo, V. H., Francis, R. J., Armato, S. G. (2023) Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Journal of Thoracic Oncology, 18, pp. 278-298. (doi: 10.1016/j.jtho.2022.11.018)

Villar, V. H., Allega, M. F., Deshmukh, R., Ackermann, T., Nakasone, M. A., Vande Voorde, J., Drake, T. M., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E. H., Vereecke, L., Jans, M., Blancke, G., Murphy, D. J., Huang, D. T., Lewis, D. Y., Bird, T. G., Sansom, O. J., Blyth, K., Sumpton, D., Tardito, S. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19, pp. 292-300. (doi: 10.1038/s41589-022-01154-9)

Schmidt, T., Dąbrowska, A., Waldron, J. A., Hodge, K., Koulouras, G., Gabrielsen, M., Munro, J., Tack, D. C., Harris, G., McGhee, E., Scott, D., Carlin, L. M., Huang, D., Le Quesne, J., Zanivan, S., Wilczynska, A., Bushell, M. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51, pp. 1859-1879. (doi: 10.1093/nar/gkad030)

Grocutt, L., Rutherford, A., Caldwell, D., Wilkinson, C., Chalmers, A.J., Dempsey, L., Kelly, C., O'Cathail, S.M. (2023) The impact of COVID-19 on radiotherapy services in Scotland, UK: a population-based study. Clinical Oncology, 35, pp. e227-e234. (doi: 10.1016/j.clon.2022.11.018)

Koessinger, D., Novo, D., Koessinger, A., Campos, A., Peters, J., Dutton, L., Paschke, P., Zerbst, D., Moore, M., Mitchell, L., Neilson, M., Stevenson, K., Chalmers, A., Tait, S., Birch, J., Norman, J. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5, (doi: 10.1093/noajnl/vdad067)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10, (doi: 10.1136/openhrt-2022-002192)

2022

O'Cathail, S.M., Chalmers, A.J. (2022) Integrating novel cancer therapies with radiation - illuminating the tunnel. Clinical Oncology, 35, pp. 38-41. (doi: 10.1016/j.clon.2022.10.010)

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9, (doi: 10.1126/sciadv.abq1858)

Kidd, A. C., Anderson, O., Cowell, G. W., Weir, A. J., Voisey, J. P., Evison, M., Tsim, S., Goatman, K. A., Blyth, K. G. (2022) Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria. Thorax, 77, pp. 1251-1259. (doi: 10.1136/thoraxjnl-2021-217808)

van Wagensveld, L., van Baal, J. O. A. M., Timmermans, M., Gaillard, D., Borghuis, L., Coffelt, S. B., Rosenberg, E. H., Lok, C. A. R., Nijman, H. W., Kooreman, L. F. S., Sanders, J., de Bruijn, M., Wessels, L. F. A., van der Wiel, R., Rausch, C., Broeks, A., Kruitwagen, R. F. P. M., van der Aa, M. A., Sonke, G. S., Schouten, P. C., Van de Vijver, K. K., Horlings, H. M. (2022) Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer. Cancers, 14, (doi: 10.3390/cancers14235965)

Falcone, M., Huerta Uribe, A., Papalazarou, V., Newman, A. C., Athineos, D., Stevenson, K., Sauvé, C.-E. G., Gao, Y., Kim, J. K., Del Latto, M., Kierstead, M., Wu, C., Smith, J. J., Romesser, P. B., Chalmers, A. J., Blyth, K., Maddocks, O. D.K. (2022) Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. British Journal of Cancer, 127, pp. 1773-1786. (doi: 10.1038/s41416-022-01965-6)

Conway, R. J. H., Symonds, J., Walton, D., Probets, J., Comins, C., Stadon, L., Harvey, J. E., Blyth, K. G., Maskell, N. A., Bibby, A. C. (2022) Protocol for a prospective observational cohort study collecting data on demographics, symptoms and biomarkers in people with mesothelioma (ASSESS-meso) BMJ Open, 12, (doi: 10.1136/bmjopen-2022-060850)

Edwards, S. C., Hedley, A., Hoevenaar, W. H.M., Wiesheu, R., Glauner, T., Kilbey, A., Shaw, R., Boufea, K., Batada, N., Hatano, S., Yoshikai, Y., Blyth, K., Miller, C., Kirschner, K., Coffelt, S. B. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220, (doi: 10.1084/jem.20211431)

Yanchus, C. et al. (2022) A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. Science, 378, pp. 68-78. (doi: 10.1126/science.abj2890)

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29, pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3)

Ji, Y., Cutiongco, M. F.A., Jensen, B. S., Yuan, K. (2022) CP2Image: Generating High-Quality Single-Cell Images Using CellProfiler Representations.

Liu, X., Yang, X., Ouyang, L., Guo, G., Su, J., Xi, R., Yuan, K., Yuan, F. (2022) Protein Language Model Predicts Mutation Pathogenicity and Clinical Prognosis.

Freckmann, E. C., Sandilands, E., Cumming, E., Neilson, M., Roman-Fernandez, A., Nikolatou, K., Nacke, M., Lannagan, T. R.M., Hedley, A., Strachan, D., Salji, M., Morton, J. P., McGarry, L., Leung, H. Y., Sansom, O. J., Miller, C. J., Bryant, D. M. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, (doi: 10.1038/s41467-022-32958-x)

Bedawi, E. O., Ur Rehman, K., Sivakumar, D. P., Ferguson, K., Ajmal, S., Graham, E., Panchal, R. K., Corcoran, J. P., Blyth, K. G., Rahman, N. M., West, A. (2022) The impact of the COVID-19 pandemic on pleural infection incidence: a UK multicentre retrospective analysis. ERJ Open Research, 8, (doi: 10.1183/23120541.00206-2022)

Morrow, A. J. et al. (2022) A multisystem, cardio-renal investigation of post-COVID-19 illness. Nature Medicine, 28, pp. 1303-1313. (doi: 10.1038/s41591-022-01837-9)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4, pp. 693-710. (doi: 10.1038/s42255-022-00582-0)

McAleavey, P. G., Walls, G. M., Chalmers, A. J. (2022) Radiotherapy-drug combinations in the treatment of glioblastoma: a brief review. CNS Oncology, 11, (doi: 10.2217/cns-2021-0015)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Lawrence, M., Wiesheu, R., Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, (doi: 10.1016/j.biocel.2022.106213)

Rosas, I. O. et al. (2022) Tocilizumab in patients hospitalised with COVID-19 pneumonia: efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA) EClinicalMedicine, 47, (doi: 10.1016/j.eclinm.2022.101409)

Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14, (doi: 10.15252/emmm.202114764)

Willers, H., Krause, M., Faivre-Finn, C., Chalmers, A. (2022) Targeting PARP for chemoradiosensitization: opportunities, challenges, and the road ahead. International Journal of Radiation Oncology, Biology, Physics, 112, pp. 265-270. (doi: 10.1016/j.ijrobp.2021.10.142)

Quinn, T. M. et al. (2022) Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics. EBioMedicine, 76, (doi: 10.1016/j.ebiom.2022.103856)

Jackson, M. R., Stevenson, K., Chahal, S. K., Curley, E., Finney, G. E., Gutierrez-Quintana, R., Onwubiko, E., Rupp, A., Strathdee, K., Williams, K., MacLeod, M. K.L., McSharry, C., Chalmers, A. J. (2022) Low-dose lung radiotherapy for COVID-19 lung disease: a preclinical efficacy study in a bleomycin model of pneumonitis. International Journal of Radiation Oncology, Biology, Physics, 112, pp. 197-211. (doi: 10.1016/j.ijrobp.2021.08.029)

Aiyappa-Maudsley, R., Chalmers, A. J., Parsons, J. L. (2022) Factors affecting the radiation response in glioblastoma. Neuro-Oncology Advances, 4, (doi: 10.1093/noajnl/vdac156)

Gutierrez-Quintana, R., Walker, D. J., Williams, K. J., Forster, D. M., Chalmers, A. J. (2022) Radiation-induced neuroinflammation: a potential protective role for poly(ADP-ribose) polymerase inhibitors? Neuro-Oncology Advances, 4, (doi: 10.1093/noajnl/vdab190)

Derby, S. J., Chalmers, A. J., Carruthers, R. (2022) Radiotherapy-poly(ADP-ribose) polymerase inhibitor combinations: progress to date. Seminars in Radiation Oncology, 32, pp. 15-28. (doi: 10.1016/j.semradonc.2021.09.005)

Paterson, K., Paterson, S., Mulholland, T., Coffelt, S.B., Zagnoni, M. (2022) Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy. IEEE Open Journal of Engineering in Medicine and Biology, 3, pp. 86-95. (doi: 10.1109/OJEMB.2022.3178302)

Curio, S., Edwards, S. C., Suzuki, T., McGovern, J., Triulzi, C., Yoshida, N., Jonsson, G., Glauner, T., Rami, D., Wiesheu, R., Kilbey, A., Purcell, R. V., Coffelt, S. B., Guerra, N. (2022) NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1, (doi: 10.1093/discim/kyac002)

2021

McPeake, J., Shaw, M., Mactavish, P., Blyth, K., Devine, H., Fleming, G., Gemmell, L., Griffin, J., Grose, P., Henderson, P., Hogg, L., King, K., McInnes, I., O'Brien, P., Puxty, K., Rainey, C., Sharma, V., Sim, M., Strachan, L., Siebert, S., Quasim, T. (2021) Long-term outcomes following severe COVID-19 infection: a multicentre cohort study of family member outcomes. Annals of the American Thoracic Society, 18, pp. 2098-2101. (doi: 10.1513/AnnalsATS.202104-481RL)

Johnson, S. A., Ormsby, M. J., Wessel, H., Hulme, H., Bravo-Blas, A., McIntosh, A., Mason, S., Coffelt, S., Tait, S. W.G., Mcl. Mowat, A., Milling, S., Blyth, K., Wall, D. M. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51, pp. 3228-3238. (doi: 10.1002/eji.202048913)

Berry, C. et al. (2021) Post-COVID-19 illness trajectory: a multisystem investigation [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1053331/v1)

Asciak, R., Kanellakis, N. I., Bibby, A., Kidd, A., Gerry, S., Mercer, R., Maskell, N., Blyth, K. G., Fsadni, P., Montefort, S., Psallidas, I., Rahman, N. M. (2021) The association between pleural fluid exposure and survival in pleural mesothelioma. Chest, 160, pp. 1925-1933. (doi: 10.1016/j.chest.2021.05.063)

Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16, pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018)

Claudio Quiros, A., Coudray, N., Yeaton, A., Sunhem, W., Murray-Smith, R., Tsirigos, A., Yuan, K. (2021) Adversarial Learning of Cancer Tissue Representations. (doi: 10.1007/978-3-030-87237-3_58)

Bao, J., Närhi, K., Teodòsio, A., Hemmes, A., Linnavirta, N. M., Mäyränpää, M. I., Salmenkivi, K., Le Quesne, J., Verschuren, E. W. (2021) SOX9 has distinct roles in the formation and progression of different non‐small cell lung cancer histotypes. Journal of Pathology, 255, pp. 16-29. (doi: 10.1002/path.5733)

Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, (doi: 10.1038/s41467-021-25173-7)

Ghaddar, N., Wang, S., Woodvine, B., Krishnamoorthy, J., van Hoef, V., Darini, C., Kazimierczak, U., Ah-son, N., Popper, H., Johnson, M., Officer, L., Teodósio, A., Broggini, M., Mann, K. K., Hatzoglou, M., Topisirovic, I., Larsson, O., Le Quesne, J., Koromilas, A. E. (2021) The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer. Nature Communications, 12, (doi: 10.1038/s41467-021-24661-0)

Ntala, C., Salji, M., Salmond, J., Officer, L., Teodosio, A. V., Blomme, A., McGhee, E. J., Powley, I., Ahmad, I., Kruithof-de Julio, M., Thalmann, G., Roberts, E., Goodyear, C. S., Jamaspishvili, T., Berman, D. M., Carlin, L. M., Le Quesne, J., Leung, H. Y. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001)

Paterson, K., Zanivan, S., Glasspool, R., Coffelt, S.B., Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21, pp. 2306-2329. (doi: 10.1039/D0LC01305F)

Koessinger, A. L., Koessinger, D., Kinch, K., Martínez-Escardó, L., Paul, N. R., Elmasry, Y., Malviya, G., Cloix, C., Campbell, K. J., Bock, F. J., O'Prey, J., Stevenson, K., Nixon, C., Jackson, M. R., Ichim, G., Stewart, W., Blyth, K., Ryan, K. M., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)

Nile, D. L., Rae, C., Walker, D. J., Canning Waddington, J., Vincent, I., Burgess, K., Gaze, M. N., Mairs, R. J., Chalmers, A. J. (2021) Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells. Cancer and Metabolism, 9, (doi: 10.1186/s40170-021-00258-5)

Sereno, M., He, Z., Smith, C. R., Baena, J., Das, M., Hastings, R. K., Rake, G., Fennell, D. A., Nakas, A., Moore, D. A., Le Quesne, J. (2021) Inclusion of multiple high‐risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma. Histopathology, 78, pp. 838-848. (doi: 10.1111/his.14301)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11, pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652)

Chalmers, A.J., Carruthers, R.D. (2021) Radiobiology summaries: DNA damage and repair. Clinical Oncology, 33, pp. 275-278. (doi: 10.1016/j.clon.2020.12.006)

Busacca, S., Zhang, Q., Sharkey, A., Dawson, A. G., Moore, D. A., Waller, D. A., Nakas, A., Jones, C., Cain, K., Luo, J.-l., Salcedo, A., Salaroglio, I. C., Riganti, C., Le Quesne, J., John, T., Boutros, P. C., Zhang, S.-D., Fennell, D. A. (2021) Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression. Scientific Reports, 11, (doi: 10.1038/s41598-021-86834-7)

Claudio Quiros, A., Murray-Smith, R., Yuan, K. (2021) PathologyGAN: Learning deep representations of cancer tissue. Journal of Machine Learning for Biomedical Imaging, 2021, pp. 1-48.

Zhang, M. et al. (2021) Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment. Nature Communications, 12, (doi: 10.1038/s41467-021-21798-w)

Hanna, C. R., Robb, K. A., Blyth, K. G., Jones, R. J., Chalmers, A. J. (2021) Clinician attitudes to using low dose radiotherapy to treat COVID-19 lung disease. International Journal of Radiation Oncology, Biology, Physics, 109, pp. 886-890. (doi: 10.1016/j.ijrobp.2020.12.003)

McFarlane, A. J., Fercoq, F., Coffelt, S. B., Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131, (doi: 10.1172/JCI143759)

Rulach, R., Ball, D., Chua, K., Dahele, M., De Ruysscher, D., Franks, K., Gomez, D., Guckenberger, M., Hanna, G., Louie, A., Moghanaki, D., Palma, D., Peedell, C., Salem, A., Silva, S., Videtic, G., Chalmers, A., Harrow, S. (2021) An international expert survey on the indications and practice of radical thoracic reirradiation for non-small cell lung cancer. Advances in Radiation Oncology, 6, (doi: 10.1016/j.adro.2021.100653)

Yun, S., Vincelette, N. D., Yu, X., Watson, G. W., Fernandez, M. R., Yang, C., Hitosugi, T., Cheng, C.-H., Freischel, A. R., Zhang, L., Li, W., Hou, H., Schaub, F. X., Vedder, A. R., Cen, L., McGraw, K. L., Moon, J., Murphy, D. J., Ballabio, A., Kaufmann, S. H., Berglund, A. E., Cleveland, J. L. (2021) TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia. Blood Cancer Discovery, 2, pp. 162-185. (doi: 10.1158/2643-3230.bcd-20-0029)

Phatak, V., von Grabowiecki, Y., Janus, J., Officer, L., Behan, C., Aschauer, L., Pinon, L., Mackay, H., Zanivan, S., Norman, J. C., Kelly, M., Le Quesne, J., Muller, P. A. J. (2021) Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. Cell Death and Disease, 12, (doi: 10.1038/s41419-021-03497-y)

Liu, Q., Palomero, L., Moore, J., Guiz, I., Espín, R., Aytés, A., Mao, J.-H., Paulovich, A. G., Whiteaker, J. R., Ivey, R. G., Iliakis, G., Luo, D., Chalmers, A. J., Murnane, J., Pujana, M. A., Barcellos-Hoff, M. H. (2021) Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Science Translational Medicine, 13, (doi: 10.1126/scitranslmed.abc4465)

Jensen, M. P., Le Quesne, J., Officer‐Jones, L., Teodòsio, A., Thaventhiran, J., Ficken, C., Goddard, M., Smith, C., Menon, D., Allinson, K. S. J. (2021) Neuropathological findings in two patients with fatal COVID‐19. Neuropathology and Applied Neurobiology, 47, pp. 17-25. (doi: 10.1111/nan.12662)

Edwards, S. C., Hoevenaar, W. H.M., Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5)

Al-mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Chalmers, A.J., Holmes, W.M. (2021) Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of glioblastoma. Magnetic resonance imaging, 85, pp. 121-127. (doi: 10.1016/j.mri.2021.10.030)

Hadjiyiannakis, D., Dimitroyannis, D., Eastlake, L., Peedell, C., Tripathi, L., Simcock, R., Vyas, A., Deutsch, E., Chalmers, A.J. (2021) Personal view: low-dose lung radiotherapy should be evaluated as a treatment for severe COVID-19 lung disease. Clinical Oncology, 33, pp. e64-e68. (doi: 10.1016/j.clon.2020.08.003)

Dentro, S. C. et al. (2021) Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. Cell, 184, pp. 2239-2254.e39. (doi: 10.1016/j.cell.2021.03.009)

Macintyre, G., Piskorz, A. M., Berman, A., Ross, E., Morse, D. B., Yuan, K., Ennis, D., Pike, J. A., Goranova, T., Mcneish, I. A., Brenton, J. D., Markowetz, F. (2021) FrenchFISH: Poisson Models for Quantifying DNA Copy Number From Fluorescence In Situ Hybridization of Tissue Sections. JCO Clinical Cancer Informatics, 5, pp. 176-186. (doi: 10.1200/cci.20.00075)

McPeake, J., Shaw, M., Mactavish, P., Blyth, K., Devine, H., Fleming, G., Gemmell, L., Griffin, J., Grose, P., Henderson, M., Henderson, P., Hogg, L., King, K., McInnes, I., O'Brien, P., Puxty, K., Rainey, C., Sharma, V., Sim, M., Strachan, L., Siebert, S., Quasim, T. (2021) Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study. BMJ Open Respiratory Research, 8, (doi: 10.1136/bmjresp-2021-001080)

2020

Valtonen, S., Vuorinen, E., Kariniemi, T., Eskonen, V., Le Quesne, J., Bushell, M., Härmä, H., Kopra, K. (2020) Nanomolar Protein-Protein Interaction monitoring with a label-free protein-probe technique. Analytical chemistry, 92, pp. 15781-15788. (doi: 10.1021/acs.analchem.0c02823)

Claudio Quiros, A., Murray-Smith, R., Yuan, K. (2020) Learning a Low Dimensional Manifold of Real Cancer Tissue with PathologyGAN.

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116, pp. 2185-2196. (doi: 10.1093/cvr/cvaa209)

Tsim, S., Cowell, G. W., Kidd, A., Woodward, R., Alexander, L., Kelly, C., Foster, J. E., Blyth, K. G. (2020) A comparison between MRI and CT in the assessment of primary tumour volume in mesothelioma. Lung Cancer, 150, pp. 12-20. (doi: 10.1016/j.lungcan.2020.09.025)

Hanna, C., Kurian, K. M., Williams, K., Watts, C., Jackson, A., Carruthers, R., Strathdee, K., Cruickshank, G., Dunn, L., Erridge, S., Godfrey, L., Jefferies, S., McBain, C., Sleigh, R., McCormick, A., Pittman, M., Halford, S., Chalmers, A. J. (2020) Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial. Neuro-Oncology, 22, pp. 1840-1850. (doi: 10.1093/neuonc/noaa104)

Coffelt, S. B., Kabelitz, D., Silva-Santos, B., Kuball, J., Born, W., Bank, I. (2020) Editorial: γδ T Cells in Cancer. Frontiers in Immunology, 11, (doi: 10.3389/fimmu.2020.602411)

Hanna, C. R., Blyth, K. G., Burley, G., Carmichael, S., Evans, C., Hinsley, S., Khadra, I., Khoo, S., Lewsley, L.-A., Jones, R. R., Sharma, R., Taladriz-Sender, A., Thomson, E. C., Scott, J. T. (2020) Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19: A structured summary of a study protocol for a randomised controlled trial. Trials, 21, (doi: 10.1186/s13063-020-04891-1)

Fercoq, F., Remion, E., Vallarino-Lhermitte, N., Alonso, J., Raveendran, L., Nixon, C., Le Quesne, J., Carlin, L. M., Martin, C. (2020) Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents. Parasites and Vectors, 13, (doi: 10.1186/s13071-020-04428-0)

Duffy, C., Kidd, A. C., Francis, S., Tsim, S., McNaughton, L., Ferguson, K., Ferguson, J., Rodgers, G., Mcgroarty, C., Sayer, R., Blyth, K. G. (2020) Chest drain aerosol generation in COVID-19 and emission reduction using a simple anti-viral filter. BMJ Open, 7, (doi: 10.1136/bmjresp-2020-000710)

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J., Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298, pp. 198-217. (doi: 10.1111/imr.12916)

Claudio Quiros, A., Murray-Smith, R., Yuan, K. (2020) PathologyGAN: Learning Deep Representations of Cancer Tissue.

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, (doi: 10.1038/s41598-020-72322-x)

Bailey, M. H. et al. (2020) Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11, (doi: 10.1038/s41467-020-18151-y)

Rae, C., Fragkoulis, G. I., Chalmers, A. J. (2020) Cytotoxicity and radiosensitizing activity of the fatty acid synthase inhibitor C75 is enhanced by blocking fatty acid uptake in prostate cancer cells. Advances in Radiation Oncology, 5, pp. 944-1005. (doi: 10.1016/j.adro.2020.06.022)

Li, C. H. et al. (2020) Sex differences in oncogenic mutational processes. Nature Communications, 11, (doi: 10.1038/s41467-020-17359-2)

Ferguson, K., Quail, N., Kewin, P., Blyth, K. G. (2020) COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis. BMJ Case Reports, 13, (doi: 10.1136/bcr-2020-237460)

Rodrigues, F. S., Miranda, V. S., Carneiro-Lobo, T. C., Scalabrini, L. C., Kruspig, B., Levantini, E., Murphy, D. J., Bassères, D. S. (2020) IKKβ kinase promotes stemness, migration, and invasion in KRAS-driven lung adenocarcinoma cells. International Journal of Molecular Sciences, 21, (doi: 10.3390/ijms21165806)

Curtin, N., Bányai, K., Thaventhiran, J., Le Quesne, J., Helyes, Z., Bai, P. (2020) Repositioning PARP inhibitors for SARS‐CoV‐2 infection(COVID‐19); a new multi‐pronged therapy for acute respiratory distress syndrome? British Journal of Pharmacology, 177, pp. 3635-3645. (doi: 10.1111/bph.15137)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M., Blyth, K., Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14, pp. 1868-1880. (doi: 10.1002/1878-0261.12734)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S., Blyth, K., Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12, (doi: 10.3390/nu12082181)

AbdulJabbar, K. et al. (2020) Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. Nature Medicine, 26, pp. 1054-1062. (doi: 10.1038/s41591-020-0900-x)

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., Neidler, S., Rink, C., Karim, S. A., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A. V., Carlin, L. M., Coffelt, S. B., Sansom, O. J., Morton, J. P., Murphy, D. J. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10, pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620)

Kos, Z. et al. (2020) Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer. npj Breast Cancer, 6, (doi: 10.1038/s41523-020-0156-0)

Litchfield, K. et al. (2020) Representative sequencing: unbiased sampling of solid tumor tissue. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107550)

Gonzalez‐Ericsson, P. I. et al. (2020) The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers in breast cancer clinical trials and daily practice. Journal of Pathology, 250, pp. 667-684. (doi: 10.1002/path.5406)

Jackson, M. R., Ashton, M., Koessinger, A. L., Dick, C., Verheij, M., Chalmers, A. J. (2020) Mesothelioma cells depend on the anti-apoptotic protein Bcl-xL for survival and are sensitized to ionizing radiation by BH3-mimetics. International Journal of Radiation Oncology, Biology, Physics, 106, pp. 867-877. (doi: 10.1016/j.ijrobp.2019.11.029)

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, , Bailey, P. J., Chang, D. K., Cooke, S. L., Biankin, A. V., Duthie, F. R., Graham, J. S., Jamieson, N. B., Musgrove, E. A., Martin, S., Yuan, K., Wright, D. W., Oien, K. A. (2020) Pan-cancer analysis of whole genomes. Nature, 578, pp. 82-93. (doi: 10.1038/s41586-020-1969-6)

Gerstung, M. et al. (2020) The evolutionary history of 2,658 cancers. Nature, 578, pp. 122-128. (doi: 10.1038/s41586-019-1907-7)

Cmero, M., Yuan, K., Ong, C. S., Schröder, J., PCAWG Evolution and Heterogeneity Working Group, , Corcoran, N. M., Papenfuss, T., Hovens, C. M., Markowetz, F., Macintyre, G., PCAWG Consortium, (2020) Inferring structural variant cancer cell fraction. Nature Communications, 11, (doi: 10.1038/s41467-020-14351-8)

Rubanova, Y., Shi, R., Harrigan, C. F., Li, R., Wintersinger, J., Sahin, N., Deshwar, A., Morris, Q. (2020) Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nature Communications, 11, (doi: 10.1038/s41467-020-14352-7)

Mohan, S., Foy, V., Ayub, M., Leong, H. S., Schofield, P., Sahoo, S., Descamps, T., Kilerci, B., Smith, N. K., Carter, M., Priest, L., Zhou, C., Carr, T. H., Miller, C., Faivre-Finn, C., Blackhall, F., Rothwell, D. G., Dive, C., Brady, G. (2020) Profiling of circulating free DNA using targeted and genome-wide sequencing in patients with SCLC. Journal of Thoracic Oncology, 15, pp. 216-230. (doi: 10.1016/j.jtho.2019.10.007)

Gomez-Roman, N., Chong, M. Y., Chahal, S. K., Caragher, S. P., Jackson, M. R., Stevenson, K. H., Dongre, S. A., Chalmers, A. J. (2020) Radiation responses of 2D and 3D glioblastoma cells: a novel, 3D-specific radioprotective role of VEGF/Akt signaling through functional activation of NHEJ. Molecular Cancer Therapeutics, 19, pp. 575-589. (doi: 10.1158/1535-7163.MCT-18-1320)

Ferguson, J., Alexander, L., Kelly, C., Chalmers, A., Rahman, N., Holme, J., Grundy, S., Ahmed, L., Maskell, N., Cowell, G., Dick, C., Tsim, S., Hopkins, T., Woodward, R., Blyth, K. (2020) Staging by Thoracoscopy in Potentially Radically Treatable Non-Small Cell Lung Cancer Associated with Minimal Pleural Effusion (STRATIFY) study: a prospective multicentre study. Lung Cancer, 139, (doi: 10.1016/S0169-5002(20)30245-2)

Chalmers, A.J., Chan, C., Sebag-Montefiore, D. (2020) CTRad 10 years on: from 10-point plan to top 10 achievements. Clinical Oncology, 32, pp. 9-12. (doi: 10.1016/j.clon.2019.09.043)

Officer, L. K., Andreou, K. E., Teodósio, A. V., He, Z., Le Quesne, J. P. (2020) Automated co-in situ hybridization and immunofluorescence using archival tumor tissue. Springer

Ghaddar, N., Wang, S., Woodvine, B., Krishnamoorthy, J., Darini, C., Van Hoef, V., Popper, H., Topisirovic, I., Larsson, O., Le Quesne, J., Koromilas, A. (2020) The integrated stress response exposes a therapeutic vulnerability in KRAS driven lung cancer. European Journal of Cancer, 138, pp. S23. (doi: 10.1016/S0959-8049(20)31126-6)

2019

Waldron, J. A., Tack, D. C., Ritchey, L. E., Gillen, S. L., Wilczynska, A., Turro, E., Bevilacqua, P. C., Assmann, S. M., Bushell, M., Le Quesne, J. (2019) mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Genome Biology, 20, (doi: 10.1186/s13059-019-1901-2)

Le Quesne, J., Pritchard, C., Officer, L., Kamata, T., Smith, C., Sereno, M., Das, M., Baena, J., Al Dujaily, E. (2019) Reduced protumorigenic tumor-associated macrophages with statin use in premalignant human lung adenocarcinoma. JNCI Cancer Spectrum, 4, (doi: 10.1093/jncics/pkz101)

Wilczynska, A., Gillen, S. L., Schmidt, T., Meijer, H. A., Jukes-Jones, R., Langlais, C., Kopra, K., Lu, W.-T., Godfrey, J. D., Hawley, B. R., Hodge, K., Zanivan, S., Cain, K., Le Quesne, J., Bushell, M. (2019) eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5’UTR. Genome Biology, 20, (doi: 10.1186/s13059-019-1857-2)

Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P., Chalmers, A. J. (2019) An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment? CNS Oncology, 8, (doi: 10.2217/cns-2019-0017)

Beckta, J. M., Bindra, R. S., Chalmers, A. J. (2019) Targeting DNA repair in gliomas. Current Opinion in Neurology, 32, pp. 878-885. (doi: 10.1097/WCO.0000000000000760)

Bott, A. J. et al. (2019) Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Reports, 29, pp. 1287-1298.e6. (doi: 10.1016/j.celrep.2019.09.056)

Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25, pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1)

Al-Mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Gilmour, L., Foster, J., Chalmers, A.J., Holmes, W.M. (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: application to an infiltrative brain tumour model. Journal of Neuroscience Methods, 326, (doi: 10.1016/j.jneumeth.2019.108372)

Venkataramani, V. et al. (2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature, 573, pp. 532-538. (doi: 10.1038/s41586-019-1564-x)

Fercoq, F., Remion, E., Frohberger, S. J., Vallarino-Lhermitte, N., Hoerauf, A., Le Quesne, J., Landmann, F., Hübner, M. P., Carlin, L. M., Martin, C. (2019) IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation. PLoS Neglected Tropical Diseases, 13, (doi: 10.1371/journal.pntd.0007691)

Wellenstein, M. D., Coffelt, S. B., Duits, D. E.M., van Miltenburg, M. H., Slagter, M., de Rink, I., Henneman, L., Kas, S. M., Prekovic, S., Hau, C.-S., Vrijland, K., Drenth, A. P., de Korte-Grimmerink, R., Schut, E., van der Heijden, I., Zwart, W., Wessels, L. F.A., Schumacher, T. N.M., Jonkers, J., de Visser, K. E. (2019) Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis. Nature, 572, pp. 538-542. (doi: 10.1038/s41586-019-1450-6)

Palma, D. A. et al. (2019) Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial. BMC Cancer, 19, (doi: 10.1186/s12885-019-5977-6)

Mackey, J. B.G., Coffelt, S. B., Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, (doi: 10.3389/fimmu.2019.01912)

Vallatos, A., Al-Mubarak, H.F.I., Birch, J.L., Gallagher, L., Mullin, J.M., Gilmour, L., Holmes, W.M., Chalmers, A.J. (2019) Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. Journal of Magnetic Resonance Imaging, 50, pp. 529-540. (doi: 10.1002/jmri.26580)

Kokurewicz, K., Brunetti, E., Welsh, G.H., Wiggins, S.M., Boyd, M., Sorensen, A., Chalmers, A.J., Schettino, G., Subiel, A., DesRosiers, C., Jaroszynski, D.A. (2019) Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. Scientific Reports, 9, (doi: 10.1038/s41598-019-46630-w)

Tsim, S., Paterson, S., Cartwright, D., Fong, C. J., Alexander, L., Kelly, C., Holme, J., Evison, M., Blyth, K. G. (2019) Baseline predictors of negative and incomplete pleural cytology in patients with suspected pleural malignancy - Data supporting 'Direct to LAT' in selected groups. Lung Cancer, 133, pp. 123-129. (doi: 10.1016/j.lungcan.2019.05.017)

Gomez-Roman, N., Chalmers, A. J. (2019) Patient-specific 3D-printed glioblastomas. Nature Biomedical Engineering, 3, pp. 498-499. (doi: 10.1038/s41551-019-0379-2)

Silva-Santos, B., Mensurado, S., Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19, pp. 392-404. (doi: 10.1038/s41568-019-0153-5)

Kidd, A. C., Honney, K., Bowker, L. K., Clark, A. B., Myint, P. K., Holland, R. (2019) Doctors are inconsistent in estimating survival after CPR and are not using such predictions consistently in determining DNACPR decisions. Geriatrics, 4, (doi: 10.3390/geriatrics4020033)

Memon, D., Bi, J., Miller, C. J. (2019) In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. Scientific Reports, 9, (doi: 10.1038/s41598-019-43758-7)

Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25, pp. 738-743. (doi: 10.1038/s41591-019-0380-z)

Neidler, S., Kruspig, B., Hewit, K., Monteverde, T., Gyuraszova, K., Braun, A., Clark, W., James, D., Hedley, B., Nieswandt, B., Shanks, E., Dick, C., Murphy, D. J. (2019) Identification of a clinically relevant signature for early progression in KRAS-driven lung adenocarcinoma. Cancers, 11, (doi: 10.3390/cancers11050600)

Moore, D. A., Sereno, M., Das, M., Baena Acevedo, J. D., Sinnadurai, S., Smith, C., McSweeney, A., Su, X., Officer, L., Jones, C., Dudek, K., Guttery, D., Taniere, P., Spriggs, R. V., Le Quesne, J. (2019) In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth—a clinically relevant distinction. Modern Pathology, 32, pp. 1095-1105. (doi: 10.1038/s41379-019-0257-1)

Cunningham, Y., Wyke, S., Blyth, K. G., Rigg, D., Macdonald, S., Macleod, U., Harrow, S., Robb, K. A., Whitaker, K. L. (2019) Lung cancer symptom appraisal among people with chronic obstructive pulmonary disease: a qualitative interview study. Psycho-Oncology, 28, pp. 718-725. (doi: 10.1002/pon.5005)

Salvagno, C., Ciampricotti, M., Tuit, S., Hau, C.-S., van Weverwijk, A., Coffelt, S. B., Kersten, K., Vrijland, K., Kos, K., Ulas, T., Song, J.-Y., Ooi, C.-H., Rüttinger, D., Cassier, P. A., Jonkers, J., Schultze, J. L., Ries, C. H., de Visser, K. E. (2019) Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology, 21, pp. 511-521. (doi: 10.1038/s41556-019-0298-1)

Rosenthal, R. et al. (2019) Neoantigen-directed immune escape in lung cancer evolution. Nature, 567, pp. 479-485. (doi: 10.1038/s41586-019-1032-7)

Gobin, M., Nazarov, P. V., Warta, R., Timmer, M., Reifenberger, G., Felsberg, J., Vallar, L., Chalmers, A. J., Herold-Mende, C. C., Goldbrunner, R., Niclou, S. P., Van Dyck, E. (2019) A DNA repair and cell cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications. Cancer Research, 79, pp. 1226-1238. (doi: 10.1158/0008-5472.CAN-18-2076)

Scopelliti, A., Bauer, C., Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J., Vidal, M., Maddocks, O. D.K., Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29, pp. 269-284.e10. (doi: 10.1016/j.cmet.2018.09.021)

Parry, M. A., Srivastava, S., Ali, A., Cannistraci, A., Antonello, J., Barros-Silva, J. D., Ubertini, V., Ramani, V., Lau, M., Shanks, J., Nonaka, D., Oliveira, P., Hambrock, T., Leong, H. S., Dhomen, N., Miller, C., Brady, G., Dive, C., Clarke, N. W., Marais, R., Baena, E. (2019) Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer. European Urology Oncology, 2, pp. 1-11. (doi: 10.1016/j.euo.2018.08.005)

Lallo, A., Gulati, S., Schenk, M. W., Khandelwal, G., Berglund, U. W., Pateras, I. S., Chester, C. P. E., Pham, T. M., Kalderen, C., Frese, K. K., Gorgoulis, V. G., Miller, C., Blackhall, F., Helleday, T., Dive, C. (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176, pp. 436-450. (doi: 10.1111/bph.14542)

Caragher, S., Chalmers, A. J., Gomez-Roman, M. (2019) Glioblastoma's next top model: novel culture systems for brain cancer radiotherapy research. Cancers, 11, (doi: 10.3390/cancers11010044)

Rakhit, C. P., Trigg, R. M., Le Quesne, J., Kelly, M., Shaw, J. A., Pritchard, C., Martins, L. M. (2019) Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA. Disease Models and Mechanisms, 12, (doi: 10.1242/dmm.036863)

Rutherford, A., Stevenson, K., Tulk, A., Chalmers, A. J. (2019) Evaluation of four different small animal radiation plans on tumour and normal tissue dosimetry in a glioblastoma mouse model. British Journal of Radiology, 92, (doi: 10.1259/bjr.20180469)

2018

Kim, C. S., Mohan, S., Ayub, M., Rothwell, D. G., Dive, C., Brady, G., Miller, C. (2018) In silico error correction improves cfDNA mutation calling. Bioinformatics, 35, pp. 2380-2385. (doi: 10.1093/bioinformatics/bty1004)

Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A. M., Markowetz, F., The PCAWG Evolution and Heterogeneity Working Group, , Spellman, P. T., Morris, Q. D., Lingjærde, O. C., Wedge, D. C., Van Loo, P., Yuan, K. (2018) Neutral tumor evolution? Nature Genetics, 50, pp. 1630-1633. (doi: 10.1038/s41588-018-0258-x)

Amelio, I., Mancini, M., Petrova, V., Cairns, R. A., Vikhreva, P., Nicolai, S., Marini, A., Antonov, A. A., Le Quesne, J., Baena Acevedo, J. D., Dudek, K., Sozzi, G., Pastorino, U., Knight, R. A., Mak, T. W., Melino, G. (2018) p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Proceedings of the National Academy of Sciences of the United States of America, 115, pp. E10869-E10878. (doi: 10.1073/pnas.1808314115)

Birch, J. L., Strathdee, K., Gilmour, L., Vallatos, A., McDonald, L., Kouzeli, A., Vasan, R., Qaisi, A. H., Croft, D. R., Crighton, D., Gill, K., Gray, C. H., Konczal, J., Mezna, M., McArthur, D., Schüttelkopf, A. W., McConnell, P., Sime, M., Holmes, W. M., Bower, J., McKinnon, H. J., Drysdale, M., Olson, M. F., Chalmers, A. J. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78, pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697)

Sharma, R. A. et al. (2018) Clinical development of new drug–radiotherapy combinations. Nature Reviews Clinical Oncology, 13, pp. 627-642. (doi: 10.1038/nrclinonc.2016.79)

Lindsay, C. R. et al. (2018) Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme. ESMO Open, 3, (doi: 10.1136/esmoopen-2018-000408)

Lallo, A., Frese, K. K., Morrow, C. J., Sloane, R., Gulati, S., Schenk, M. W., Trapani, F., Simms, N., Galvin, M., Brown, S., Hodgkinson, C. L., Priest, L., Hughes, A., Lai, Z., Cadogan, E., Khandelwal, G., Simpson, K. L., Miller, C., Blackhall, F., O'Connor, M. J., Dive, C. (2018) The combination of the PARP inhibitor Olaparib and the WEE1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer. Clinical Cancer Research, 24, pp. 5153-5164. (doi: 10.1158/1078-0432.CCR-17-2805)

Carruthers, R. D., Ahmed, S. U., Ramachandran, S., Strathdee, K., Kurian, K. M., Hedley, A., Gomez-Roman, N., Kalna, G., Neilson, M. P., Gilmour, L., Stevenson, K. H., Hammond, E. M., Chalmers, A. J. (2018) Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research, 78, pp. 5060-5071. (doi: 10.1158/0008-5472.CAN-18-0569)

Lazarus, K. A., Hadi, F., Zambon, E., Bach, K., Santolla, M.-F., Watson, J. K., Correia, L. L., Das, M., Ugur, R., Pensa, S., Becker, L., Campos, L. S., Ladds, G., Liu, P., Evan, G. I., McCaughan, F. M., Le Quesne, J., Lee, J.-H., Calado, D., Khaled, W. T. (2018) BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma. Nature Communications, 9, (doi: 10.1038/s41467-018-05790-5)

Mackay, H. L., Moore, D., Hall, C., Birkbak, N. J., Jamal-Hanjani, M., Karim, S. A., Phatak, V. M., Piñon, L., Morton, J. P., Swanton, C., Le Quesne, J., Muller, P. A.J. (2018) Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9, (doi: 10.1038/s41467-018-05368-1)

Martinez-Zubiaurre, I., Chalmers, A. J., Hellevik, T. (2018) Radiation-induced transformation of immunoregulatory networks in the tumor stroma. Frontiers in Immunology, 9, (doi: 10.3389/fimmu.2018.01679)

Muthalagu, N., Murphy, D. J. (2018) Is oxidative stress MYC’s Achilles heel? Cell Death and Differentiation, 25, pp. 1189-1190. (doi: 10.1038/s41418-018-0117-4)

Dong, L.-Q., Shi, Y., Ma, L.-J., Yang, L.-X., Wang, X.-Y., Zhang, S., Wang, Z.-C., Duan, M., Zhang, Z., Liu, L.-Z., Zheng, B.-H., Ding, Z.-B., Ke, A.-W., Gao, D.-M., Yuan, K., Zhou, J., Fan, J., Xi, R., Gao, Q. (2018) Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma. Journal of Hepatology, 69, pp. 89-98. (doi: 10.1016/j.jhep.2018.02.029)

Torres-Ayuso, P., Sahoo, S., Ashton, G., An, E., Simms, N., Galvin, M., Leong, H. S., Frese, K. K., Simpson, K., Cook, N., Hughes, A., Miller, C. J., Marais, R., Dive, C., Krebs, M. G., Brognard, J. (2018) Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin. npj Genomic Medicine, 3, (doi: 10.1038/s41525-018-0055-6)

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P., Murphy, D. J. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aao2565)

Martin, G. A., Tsim, S., Kidd, A. C., Foster, J. E., McLoone, P., Chalmers, A., Blyth, K. G. (2018) Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2018-000293)

Zmuda, F., Blair, A., Liuzzi, M. C., Malviya, G., Chalmers, A. J., Lewis, D., Sutherland, A., Pimlott, S. L. (2018) An 18F-labeled poly(ADP-ribose) polymerase positron emission tomography imaging agent. Journal of Medicinal Chemistry, 61, pp. 4103-4114. (doi: 10.1021/acs.jmedchem.8b00138)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8, pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533)

Gray, E., Butler, H. J., Board, R., Brennan, P. M., Chalmers, A. J., Dawson, T., Goodden, J., Hamilton, W., Hegarty, M. G., James, A., Jenkinson, M. D., Kernick, D., Lekka, E., Livermore, L. J., Mills, S. J., O’Neill, K., Palmer, D. S., Vaqas, B., Baker, M. J. (2018) Health economic evaluation of a serum-based blood test for brain tumour diagnosis: exploration of two clinical scenarios. BMJ Open, 8, (doi: 10.1136/bmjopen-2017-017593)

Hudson, A. M., Stephenson, N. L., Li, C., Trotter, E., Fletcher, A. J., Katona, G., Bieniasz-Krzywiec, P., Howell, M., Wirth, C., Furney, S., Miller, C. J., Brognard, J. (2018) Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. Science Signaling, 11, (doi: 10.1126/scisignal.aan6776)

Arce Vargas, F. et al. (2018) Fc effector function contributes to the activity of human anti-CTLA-4 antibodies. Cancer Cell, 33, pp. 649-663.e4. (doi: 10.1016/j.ccell.2018.02.010)

Waldron, J. A., Raza, F., Le Quesne, J. (2018) eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes. Nucleic Acids Research, 46, pp. 3075-3087. (doi: 10.1093/nar/gky108)

Tsim, S., Humphreys, C. A., Cowell, G. W., Stobo, D. B., Noble, C., Woodward, R., Kelly, C. A., Alexander, L., Foster, J. E., Dick, C., Blyth, K. G. (2018) Early Contrast Enhancement: a novel Magnetic Resonance Imaging biomarker of pleural malignancy. Lung Cancer, 118, pp. 48-56. (doi: 10.1016/j.lungcan.2018.01.014)

Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J., Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37, pp. 982-992. (doi: 10.1038/onc.2017.394)

Holmes, W. M., Vallatos, A., Gilmour, L., Chalmers, A. J. (2018) Multiple boli arterial spin labelling for high signal-to-noise rodent brain perfusion imaging. Magnetic Resonance in Medicine, 79, pp. 1020-1030. (doi: 10.1002/mrm.26706)

Kolluri, K. K. et al. (2018) Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. eLife, 7, (doi: 10.7554/eLife.30224)

Haughney, J., Morice, A., Blyth, K. G., Lee, A. J., Coutts, A., McKnight, E., Pavord, I. (2018) A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels. Respiratory Medicine, 134, pp. 117-123. (doi: 10.1016/j.rmed.2017.12.001)

Sharma, V., Blyth, K. G. (2018) Empyema necessitans and a persistent air leak associated with rupture of an anaerobic lung abscess due to bacteroides. Thorax, 73, pp. 91-93. (doi: 10.1136/thoraxjnl-2017-210462)

Cherrie, J. W., McElvenny, D., Blyth, K. G. (2018) Estimating past inhalation exposure to asbestos: a tool for risk attribution and disease screening. International Journal of Hygiene and Environmental Health, 221, pp. 27-32. (doi: 10.1016/j.ijheh.2017.09.013)

Fulton, B., Short, S. C., James, A., Nowicki, S., McBain, C., Jefferies, S., Kelly, C., Stobo, J., Morris, A., Williamson, A., Chalmers, A. (2018) PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT status. Clinical and Translational Radiation Oncology, 8, pp. 12-16. (doi: 10.1016/j.ctro.2017.11.003)

Blyth, K. G., Murphy, D. J. (2018) Progress and challenges in Mesothelioma: from bench to bedside. Respiratory Medicine, 134, pp. 31-41. (doi: 10.1016/j.rmed.2017.11.015)

Ashton, M., O'Rourke, N., Macleod, N., Laird, B., Stobo, J., Kelly, C., Alexander, L., Franks, K., Moore, K., Currie, S., Valentine, R., Chalmers, A.J. (2018) SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma. Clinical and Translational Radiation Oncology, 8, pp. 45-49. (doi: 10.1016/j.ctro.2017.11.004)

Kidd, A. C., McGettrick, M., Tsim, S., Halligan, D. L., Bylesjo, M., Blyth, K. G. (2018) Survival prediction in mesothelioma using a scalable lasso regression model: instructions for use and initial performance using clinical predictors. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2017-000240)

Bennett, L., Howell, M., Memon, D., Smowton, C., Zhou, C., Miller, C. J. (2018) Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. Scientific Reports, 8, (doi: 10.1038/s41598-018-33276-3)

Thompson, M. K., Poortmans, P., Chalmers, A. J., Faivre-Finn, C., Hall, E., Huddart, R. A., Lievens, Y., Sebag-Montefiore, D., Coles, C. E. (2018) Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie? British Journal of Cancer, 119, pp. 389-407. (doi: 10.1038/s41416-018-0201-z)

Evison, M., Blyth, K. G., Bhatnagar, R., Corcoran, J., Saba, T., Duncan, T., Hallifax, R., Ahmed, L., West, A., Pepperell, J. C. T., Roberts, M., Sivasothy, P., Psallidas, I., Clive, A. O., Latham, J., Stanton, A. E., Maskell, N., Rahman, N. (2018) Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2018-000307)

2017

Rumney, R. M.H., Coffelt, S. B., Neale, T. A., Dhayade, S., Tozer, G. M., Miller, G. (2017) PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development. PLoS ONE, 12, (doi: 10.1371/journal.pone.0188591)

Walton, J. B., Farquharson, M., Mason, S., Port, J., Kruspig, B., Dowson, S., Stevenson, D., Murphy, D., Matzuk, M., Kim, J., Coffelt, S., Blyth, K., Mcneish, I. A. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, (doi: 10.1038/s41598-017-17119-1)

Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, (doi: 10.1038/s41467-017-01967-6)

Chernova, T., Murphy, F. A., Galavotti, S., Sun, X.-M., Powley, I. R., Grosso, S., Schinwald, A., Zacarias-Cabeza, J., Dudek, K. M., Dinsdale, D., Le Quesne, J., Bennett, J., Nakas, A., Greaves, P., Poland, C. A., Donaldson, K., Bushell, M., Willis, A. E., MacFarlane, M. (2017) Long-fiber carbon nanotubes replicate asbestos-induced mesothelioma with disruption of the tumor suppressor gene Cdkn2a ( Ink4a/Arf ) Current Biology, 27, pp. 3302-3314.e6. (doi: 10.1016/j.cub.2017.09.007)

Port, J., Murphy, D. J. (2017) Mesothelioma: identical routes to malignancy from asbestos and carbon nanotubes. Current Biology, 27, pp. R1173-R1176. (doi: 10.1016/j.cub.2017.07.026)

Lorimer, C.F., Hanna, C., Saran, F., Chalmers, A., Brock, J. (2017) Challenges to treating older glioblastoma patients: the influence of clinical and tumour characteristics on survival outcomes. Clinical Oncology, 29, pp. 739-747. (doi: 10.1016/j.clon.2017.05.010)

Ashton, M., O'Rourke, N., Currie, S., Rimner, A., Chalmers, A. (2017) The role of radical radiotherapy in the management of malignant pleural mesothelioma: a systematic review. Radiotherapy and Oncology, 125, pp. 1-12. (doi: 10.1016/j.radonc.2017.08.003)

Chiu, A., Ayub, M., Dive, C., Brady, G., Miller, C. J., Hancock, J. (2017) twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis. Bioinformatics, 33, pp. 2743-2745. (doi: 10.1093/bioinformatics/btx308)

Bindra, R. S., Chalmers, A. J., Evans, S., Dewhirst, M. (2017) GBM radiosensitizers: dead in the water…or just the beginning? Journal of Neuro-Oncology, 134, pp. 513-521. (doi: 10.1007/s11060-017-2427-7)

Murphy, D. J., Blyth, K. G. (2017) Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution' Cell Death and Differentiation, 24, pp. 1473-1474. (doi: 10.1038/cdd.2017.97)

Carron, E. C., Homra, S., Rosenberg, J., Coffelt, S. B., Kittrell, F., Zhang, Y., Creighton, C. J., Fuqua, S. A., Medina, D., Machado, H. L. (2017) Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget, 8, pp. 50731-50746. (doi: 10.18632/oncotarget.14913)

Khandelwal, G., Girotti, M. R., Smowton, C., Taylor, S., Wirth, C., Dynowski, M., Frese, K. K., Brady, G., Dive, C., Marais, R., Miller, C. (2017) Next-generation sequencing analysis and algorithms for PDX and CDX models. Molecular Cancer Research, 15, pp. 1012-1016. (doi: 10.1158/1541-7786.MCR-16-0431)

Blyth, K. G., Bellofiore, A., Jayasekera, G., Foster, J. E., Steedman, T., Chesler, N. C., Peacock, A. J. (2017) Dobutamine stress MRI in pulmonary hypertension: relationships between stress pulmonary artery relative area change, RV performance, and 10-year survival. Pulmonary Circulation, 7, pp. 465-475. (doi: 10.1177/2045893217704838)

Jamal-Hanjani, M. et al. (2017) Tracking the evolution of non–small-cell lung cancer. New England Journal of Medicine, 376, pp. 2109-2121. (doi: 10.1056/NEJMoa1616288)

Abbosh, C. et al. (2017) Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature, 545, pp. 446-451. (doi: 10.1038/nature22364)

Hock, A. K., Cheung, E. C., Humpton, T. J., Monteverde, T., Paulus-Hock, V., Lee, P., McGhee, E., Scopelliti, A., Murphy, D. J., Strathdee, D., Blyth, K., Vousden, K. H. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, (doi: 10.1038/s41598-017-01741-0)

Arce Vargas, F. et al. (2017) Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors. Immunity, 46, pp. 577-586. (doi: 10.1016/j.immuni.2017.03.013)

Karekla, E., Liao, W.-J., Sharp, B., Pugh, J., Reid, H., Le Quesne, J., Moore, D., Pritchard, C., MacFarlane, M., Pringle, J. H. (2017) Ex vivo explant cultures of non–small cell lung carcinoma enable evaluation of primary tumor responses to anticancer therapy. Cancer Research, 77, pp. 2029-2039. (doi: 10.1158/0008-5472.CAN-16-1121)

de Santiago, I., Liu, W., Yuan, K., O'Reilly, M., Chilamakuri, C. S. R., Ponder, B. A.J., Meyer, K. B., Markowetz, F. (2017) BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes. Genome Biology, 18, (doi: 10.1186/s13059-017-1165-7)

Gomez-Roman, N., Stevenson, K., Gilmour, L., Hamilton, G., Chalmers, A. (2017) A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses. Neuro-Oncology, 19, pp. 229-241. (doi: 10.1093/neuonc/now164)

Smowton, C., Balla, A., Antoniades, D., Miller, C., Pallis, G., Dikaiakos, M. D., Xing, W. (2017) A cost-effective approach to improving performance of big genomic data analyses in clouds. Future Generation Computer Systems, 67, pp. 368-381. (doi: 10.1016/j.future.2015.11.011)

van Baal, J.O.A.M., Van de Vijver, K.K., Coffelt, S.B., van der Noort, V., van Driel, W.J., Kenter, G.G., Buist, M.R., Lok, C.A.R. (2017) Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 486-494. (doi: 10.1111/1471-0528.14425)

Paterson, C., Allwood-Spiers, S., McCrea, I., Foster, J., McJury, M., Thomson, M., Sankaralingam, M., Grose, D., James, A., Rizwanullah, M., McLoone, P., Chalmers, A., Duffton, A. (2017) Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study. Clinical and Translational Radiation Oncology, 2, pp. 13-18. (doi: 10.1016/j.ctro.2016.12.003)

Sarosiek, K. A., Fraser, C., Muthalagu, N., Bhola, P. D., Chang, W., McBrayer, S. K., Cantlon, A., Fisch, S., Golomb-Mello, G., Ryan, J. A., Deng, J., Jian, B., Corbett, C., Goldenberg, M., Madsen, J. R., Liao, R., Walsh, D., Sedivy, J., Murphy, D. J., Carrasco, D. R., Robinson, S., Moslehi, J., Letai, A. (2017) Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell, 31, pp. 142-156. (doi: 10.1016/j.ccell.2016.11.011)

Iltzsche, F., Simon, K., Stopp, S., Pattschull, G., Francke, S., Wolter, P., Hauser, S., Murphy, D.J., Garcia, P., Rosenwald, A., Gaubatz, S. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, 36, pp. 110-121. (doi: 10.1038/onc.2016.181)

Tsim, S., Stobo, D. B., Alexander, L., Kelly, C., Blyth, K. G. (2017) The diagnostic performance of routinely acquired and reported computed tomography imaging in patients presenting with suspected pleural malignancy. Lung Cancer, 103, pp. 38-43. (doi: 10.1016/j.lungcan.2016.11.010)

Carruthers, R., Chalmers, A. J. (2017) Improving the therapeutic ratio of radiotherapy by targeting the DNA damage response. Humana Press

Kersten, K., Coffelt, S. B., Hoogstraat, M., Verstegen, N. J.M., Vrijland, K., Ciampricotti, M., Doornebal, C. W., Hau, C.-S., Wellenstein, M. D., Salvagno, C., Doshi, P., Lips, E. H., Wessels, L. F.A., de Visser, K. E. (2017) Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. OncoImmunology, 6, (doi: 10.1080/2162402X.2017.1334744)

Carter, L., Rothwell, D. G., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., Hodgkinson, C. L., Morris, K., Priest, L., Carter, M., Miller, C., Hughes, A., Blackhall, F., Dive, C., Brady, G. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23, pp. 114-119. (doi: 10.1038/nm.4239)

Draper, J. E., Sroczynska, P., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130, pp. 271-284. (doi: 10.1182/blood-2016-06-723635)

2016

Kaur, A., Denisova, O., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, S. U., Raheem, O., Haapasalo, H. K., Eriksson, J., Chalmers, A. J., Laakkonen, P. M., Westermarck, J. (2016) PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Research, 76, pp. 7001-7011. (doi: 10.1158/0008-5472.CAN-16-1134)

Marass, F., Mouliere, F., Yuan, K., Rosenfeld, N., Markowetz, F. (2016) A phylogenetic latent feature model for clonal deconvolution. Annals of Applied Statistics, 10, pp. 2377-2404. (doi: 10.1214/16-AOAS986)

Williamson, S. C. et al. (2016) Vasculogenic mimicry in small cell lung cancer. Nature Communications, 7, (doi: 10.1038/ncomms13322)

Tsim, S., Kelly, C., Alexander, L., McCormick, C., Thomson, F., Woodward, R., Foster, J. E., Stobo, D. B., Paul, J., Maskell, N. A., Chalmers, A., Blyth, K. G. (2016) Diagnostic and prognostic biomarkers in the rational assessment of mesothelioma (DIAPHRAGM) study: protocol of a prospective, multi-centre, observational study. BMJ Open, 6, (doi: 10.1136/bmjopen-2016-013324)

Lorimer, C. F., Saran, F., Chalmers, A. J., Brock, J. (2016) Glioblastoma in the elderly - how do we choose who to treat? Journal of Geriatric Oncology, 7, pp. 453-456. (doi: 10.1016/j.jgo.2016.07.005)

Armato, S. G., Blyth, K. G., Keating, J. J., Katz, S., Tsim, S., Coolen, J., Gudmundsson, E., Opitz, I., Nowak, A. K. (2016) Imaging in pleural mesothelioma: a review of the 13th International Conference of the International Mesothelioma Interest Group. (doi: 10.1016/j.lungcan.2016.09.003)

Harrow, S., Hanna, G.G., Faivre-Finn, C., McDonald, F., Chalmers, A. (2016) The challenges faced in developing novel drug radiation combinations in non-small cell lung cancer. Clinical Oncology, 28, pp. 720-725. (doi: 10.1016/j.clon.2016.08.004)

Memon, D., Dawson, K., Smowton, C. S., Xing, W., Dive, C., Miller, C. J. (2016) Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response. npj Genomic Medicine, 1, (doi: 10.1038/npjgenmed.2016.20)

Carter, L. R., Rothwell, D. G., Leong, H., Li, Y., Burt, D. J., Antonello, J., Hodgkinson, C., Morris, K., Franklin, L., Miller, C. J., Blackhall, F., Dive, C., Brady, G. (2016) Abstract 3155: Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells. (doi: 10.1158/1538-7445.AM2016-3155)

Coffelt, S. B., Wellenstein, M. D., de Visser, K. E. (2016) Neutrophils in cancer: neutral no more. Nature Reviews Cancer, 16, pp. 431-446. (doi: 10.1038/nrc.2016.52)

Morrow, C.J., Trapani, F., Metcalf, R.L., Bertolini, G., Hodgkinson, C.L., Khandelwal, G., Kelly, P., Galvin, M., Carter, L., Simpson, K.L., Williamson, S., Wirth, C., Simms, N., Frankliln, L., Frese, K.K., Rothwell, D.G., Nonaka, D., Miller, C.J., Brady, G., Blackhall, F.H., Dive, C. (2016) Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Annals of Oncology, 27, pp. 1155-1160. (doi: 10.1093/annonc/mdw122)

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M.O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B.P., Theys, J., Short, S. C., Verhaegen, F., Vooijs, M. (2016) NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. Oncotarget, 7, pp. 41251-41264. (doi: 10.18632/oncotarget.9275)

Tape, C. J., Ling, S., Dimitriadi, M., McMahon, K. M., Worboys, J. D., Leong, H. S., Norrie, I. C., Miller, C., Poulogiannis, G., Lauffenburger, D. A., Jørgensen, C. (2016) Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 165, pp. 910-920. (doi: 10.1016/j.cell.2016.03.029)

Chalmers, A. J. (2016) Science in focus: combining radiotherapy with inhibitors of the DNA damage response. Clinical Oncology, 28, pp. 279-282. (doi: 10.1016/j.clon.2016.01.035)

Coffelt, S. B., de Visser, K. E. (2016) Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor. Immunity, 44, pp. 722-724. (doi: 10.1016/j.immuni.2016.03.014)

Rothwell, D. G., Smith, N., Morris, D., Leong, H. S., Li, Y., Hollebecque, A., Ayub, M., Carter, L., Antonello, J., Franklin, L., Miller, C., Blackhall, F., Dive, C., Brady, G. (2016) Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample. Molecular Oncology, 10, pp. 566-574. (doi: 10.1016/j.molonc.2015.11.006)

Gomez-Roman, N., McGregor, F., Chalmers, A. J., Plumb, J. (2016) Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget, 7, (doi: 10.18632/oncotarget.7998)

Marusiak, A. A., Stephenson, N. L., Baik, H., Trotter, E. W., Li, Y., Blyth, K., Mason, S., Chapman, P., Puto, L. A., Read, J. A., Brassington, C., Pollard, H. K., Phillips, C., Green, I., Overman, R., Collier, M., Testoni, E., Miller, C.J., Hunter, T., Sansom, O.J., Brognard, J. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76, pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t)

Grimes, H. L., Draper, J. E., Sroczynska, P., Tsoulaki, O., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2016) RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis. PLoS Genetics, 12, (doi: 10.1371/journal.pgen.1005814)

Niyazi, M., Brada, M., Chalmers, A. J., Combs, S. E., Erridge, S. C., Fiorentino, A., Grosu, A. L., Lagerwaard, F. J., Minniti, G., Mirimanoff, R.-O., Ricardi, U., Short, S. C., Weber, D. C., Belka, C. (2016) ESTRO-ACROP guideline 'target delineation of glioblastomas' Radiotherapy and Oncology, 118, pp. 35-42. (doi: 10.1016/j.radonc.2015.12.003)

Thambyrajah, R., Mazan, M., Patel, R., Moignard, V., Stefanska, M., Marinopoulou, E., Li, Y., Lancrin, C., Clapes, T., Möröy, T., Robin, C., Miller, C., Cowley, S., Göttgens, B., Kouskoff, V., Lacaud, G. (2016) GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology, 18, pp. 21-32. (doi: 10.1038/ncb3276)

Rahat, M. A., Coffelt, S., Granot, Z., Muthana, M., Amedei, A. (2016) Macrophages and neutrophils: regulation of the inflammatory microenvironment in autoimmunity and cancer. Mediators of Inflammation, 2016, (doi: 10.1155/2016/5894347)

Coffelt, S. B., de Visser, K. E. (2016) Systemic inflammation: Cancer's long-distance reach to maximize metastasis. OncoImmunology, 5, (doi: 10.1080/2162402X.2015.1075694)

PREDICT-Meso is an international network of researchers from across the UK and worldwide, interested in the study of mesothelioma, an incurable cancer most commonly affecting the lining of the lungs and caused by exposure to asbestos fibres. The programme is funded for £5m over 6 years by the Accelerator Awards, a CRUK partnership, and comprised of 5 work-packages designed to collect and utilise human tissues and data to design new therapies and early detection tests for mesothelioma. The PREDICT-Meso Network aims to develop new research tools, resources and infrastructure to support current and future mesothelioma research including:

- a website for data and knowledge sharing -

- a PREDICT-Meso specific research tissue bank for sample collection, storage and access -

- new patient-derived cell lines

- target-drug combinations and screening

- development of mouse models

- clinical studies

- development of an AI algorithm for automated tumour scoring

- links with BRIC countries (Brazil, Russia, India, China) where asbestos is still widely used

We have direct involvement with the Scottish Mesothelioma Network (SMN), which works in partnership with Macmillan Cancer Support, Mesothelioma UK and NHS Scotland. SMN is comprised of a team of clinicians from across Scotland, collaborating via a weekly forum to share expertise and best practice, to develop high quality care plans and provide increased access to potentially life-changing clinical trials to patients wherever they live in the country.

Mesothelioma theme as part of the CRUK Scotland Centre, aims to tackle mesothelioma through model refinement and the innovation of in-human imaging and direct drug delivery.

Our research utilises a combination of classical molecular and quantitative microscopic imaging techniques to ask questions about solid tumour biology:

  • What can be observed in fully contextualised tumour tissue, the ‘natural environment’ of the malignant cell?
  • How do malignant cells interact with the microenvironment of the tumour?
  • What naturally selected strategies can be identified at a cellular scale in human and mouse tumour tissues?

Main interests are across 3 areas:

- The dysregulation of mRNA translation in tumour cells and stroma, and how this reprogramming of the genome facilitates the malignant programme at the cellular level

- The refinement and development of highly multiplexed microscopic imaging methods to reveal additional levels of single-cellular detail in spatial context (e.g. quantity and subcellular localisation of multiple gene products at mRNA and protein levels)

- The improvement of biomarkers for the prediction of personalised treatment efficacy and patient prognostication.