Lung
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Staff
Publications
2025
Cartwright, D., Kidd, A. C., Ansel, S., Ascierto, M. L., Spiliopoulou, P. (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences,
Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z)
Alkarn, A., Stapleton, L. J., Eleftheriou, D., Stewart, L., Chalmers, G., Hamed, A., Hussein, K., Blyth, K. G., van der Hors, J. C., Maclay, J. D. (2025) Real life pre-operative nodal staging accuracy in non-small cell lung cancer and its relationship with survival. Diagnostics, 15, (doi: 10.3390/diagnostics15040430)
Iwata, T., Ammar, A., Maka, N., Jawny, J., Hay, J., Martinelli, S., Officer-Jones, L., Le Quesne, J., Lynch, G., McSorley, S., Edwards, J. (2025) Does Immune Suppression in the Pre-malignant Microenvironment of Colorectal Neoplastic Lesions Associate with Development of Metachronous Polyp and Cancer Risk?
Neilly, M. D.J., Dick, C., Blyth, K. G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14, (doi: 10.1007/s13665-025-00371-6)
2024
Seyedshahi, F., Rakovic, K., Poulain, N., Claudio Quiros, A., Powley, I. R., Richards, C., Uraiby, H., Klebe, S., Nakas, A., Wilson, C., Sereno, M., Officer-Jones, L., Ficken, C., Teodosio, A., Ballantyne, F., Murphy, D., Yuan, K., Le Quesne, J. (2024) A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images. bioRxiv, (doi: 10.1101/2024.11.18.624103)
Li, C., Liu, Q., Han, L., Zhang, H., Immler, R., Rathkolb, B., Secklehner, J., de Angelis, M. H., Yildirim, A. Ö., Zeuschner, D., Nicke, A., Carlin, L. M., Sperandio, M., Stoeger, T., Rehberg, M. (2024) The eATP/P2×7R Axis drives quantum dot-nanoparticle induced neutrophil recruitment in the pulmonary microcirculation. Advanced Science, 11, (doi: 10.1002/advs.202404661)
Mactier, K., Baxter, M., Peters, A., Fair, K., Hannington, L., Robertson, J., Wood, G., Sarwar, A., Bishr, M., Webb, R., Al-Zubaidi, M., Eastlake, L., Lankester, K., McInerney, S., Creedon, H., Stillie, A., Purshouse, K. (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14, (doi: 10.1136/bmjopen-2024-094838)
Liu, D., Young, F., Lamb, K. D., Claudio Quiros, A., Pancheva, A., Miller, C., Macdonald, C., Robertson, D. L., Yuan, K. (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)
Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)
Hargrave, K. E., Worrell, J. C., Pirillo, C., Brennan, E., Masdefiol Garriga, A., Gray, J. I., Purnell, T., Roberts, E. W., MacLeod, M. K.L. (2024) Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells. Mucosal Immunology, 17, pp. 843-857. (doi: 10.1016/j.mucimm.2024.06.001)
Frankell, A. M. et al. (2024) Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631, (doi: 10.1038/s41586-024-07738-w)
Vincelette, N. D. et al. (2024) Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis. Blood Cancer Discovery, 5, pp. 276-297. (doi: 10.1158/2643-3230.BCD-23-0210)
Diaz, J. E.L., Barcessat, V., Bahamon, C., Hecht, C., Das, T. K., Cagan, R. L. (2024) Functional exploration of copy number alterations in a Drosophila model of triple negative breast cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050191)
Skalka, G. L., Whyte, D., Lubawska, D., Murphy, D. J. (2024) NUAK: never underestimate a kinase. Essays In Biochemistry, (doi: 10.1042/EBC20240005)
Quiros, A. C., Coudray, N., Yeaton, A., Yang, X., Liu, B., Le, H., Chiriboga, L., Karimkhan, A., Narula, N., Moore, D. A., Park, C. Y., Pass, H., Moreira, A. L., Le Quesne, J., Tsirigos, A., Yuan, K. (2024) Mapping the landscape of histomorphological cancer phenotypes using self-supervised learning on unannotated pathology slides. Nature Communications, 15, (doi: 10.1038/s41467-024-48666-7)
Kumar, S., Basto, A. P., Ribeiro, F., Almeida, S. C.P., Campos, P., Peres, C., Pulvirenti, N., Al-Khalidi, S., Kilbey, A., Tosello, J., Piaggio, E., Russo, M., Gama-Carvalho, M., Coffelt, S. B., Roberts, E. W., Geginat, J., Florindo, H. F., Graca, L. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, (doi: 10.1038/s41421-024-00681-0)
Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, (doi: 10.1038/s41588-024-01809-4)
Peters, A.L., Hall, P.S., Jordan, L.B., Soh, F.Y., Hannington, L., Makaranka, S., Urquhart, G., Vallet, M., Cartwright, D., Marashi, H., Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75, (doi: 10.1016/j.breast.2024.103728)
Blyth, K. G., Adusumilli, P. S., Astoul, P., Darlison, L., Lee, Y.C. G., Mansfield, A. S., Marciniak, S. J., Maskell, N., Panou, V., Peikert, T., Rahman, N. M., Zauderer, M. G., Sterman, D., Fennell, D. A. (2024) Leveraging the pleural space for anticancer therapies in pleural mesothelioma. Lancet Respiratory Medicine, 12, pp. 476-483. (doi: 10.1016/S2213-2600(24)00111-5)
Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1)
Matchett, K. P. et al. (2024) Multimodal decoding of human liver regeneration. Nature, 630, pp. 158-165. (doi: 10.1038/s41586-024-07376-2)
Thapa, A., Cowell, A., Peters, A., Noble, D. J., James, A., Lamb, C., Grose, D., Vohra, S., Schipani, S., Mactier, K., Mackenzie, J., Srinivasan, D., Laws, K., Moleron, R., Niblock, P., Soh, F.-Y., Paterson, C., Wilson, C. (2024) The UK Divide: Does having a Pembrolizumab-Chemotherapy option in head and neck cancer matter? Real-world experience of first-line palliative pembrolizumab monotherapy and pembrolizumab-chemotherapy combination in Scotland. Clinical Oncology, 36, pp. 287-299. (doi: 10.1016/j.clon.2024.02.004)
Neilly, M., Ferguson, K., Roche, J., Tate, M., Blyth, K. (2024) Mesothelioma Evolution following a Diagnosis of Benign Pleural Inflammation: A Systematic Review and Meta-Analysis. (doi: 10.1016/j.lungcan.2024.107626)
Murphy, D. J. (2024) Investigating lung cancer using genetically engineered mouse models (GEMMS) Open Access Government, 42, pp. 112-113. (doi: 10.56367/oag-042-11090)
Malviya, G., Lannagan, T. R.M., Johnson, E., Mackintosh, A., Bielik, R., Peters, A., Soloviev, D., Brown, G., Jackstadt, R., Nixon, C., Gilroy, K., Campbell, A., Sansom, O. J., Lewis, D. Y. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30, pp. 1518-1529. (doi: 10.1158/1078-0432.ccr-23-1063)
Bentley-Abbot, C., Heslop, R., Pirillo, C., Chandrasegaran, P., McConnell, G., Roberts, E., Hutchinson, E., MacLeod, A. (2024) An easy to use tool for the analysis of subcellular mRNA transcript colocalisation in smFISH data. Scientific Reports, 14, (doi: 10.1038/s41598-024-58641-3)
Hassan, M., Touman, A. A., Grabczak, E. M., Skaarup, S. H., Faber, K., Blyth, K. G., Pochepnia, S. (2024) Imaging of pleural disease. Breathe, 20, (doi: 10.1183/20734735.0172-2023)
Tárnoki, Á. D., Tárnoki, D. L., Dąbrowska, M., Knetki-Wróblewska, M., Frille, A., Stubbs, H., Blyth, K. G., Juul, A. D. (2024) New developments in the imaging of lung cancer. Breathe, 20, (doi: 10.1183/20734735.0176-2023)
Santi, A., Kay, E. J., Neilson, L. J., McGarry, L., Lilla, S., Mullin, M., Paul, N. R., Fercoq, F., Koulouras, G., Rodriguez Blanco, G., Athineos, D., Mason, S., Hughes, M., Thomson, G., Kieffer, Y., Nixon, C., Blyth, K., Mechta-Grigoriou, F., Carlin, L. M., Zanivan, S. (2024) Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science Signaling, 17, (doi: 10.1126/scisignal.ade0580)
Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, pp. 458-472. (doi: 10.1038/s41588-024-01654-5)
Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, (doi: 10.1038/s43856-024-00455-5)
Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S., Tait, S. W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43, pp. 904-930. (doi: 10.1038/s44318-024-00044-1)
Fetit, R., McLaren, A. S., White, M., Mills, M. L., Falconer, J., Cortes-Lavaud, X., Gilroy, K., Lannagan, T. R.M., Ridgway, R. A., Nixon, C., Naiker, V., Njunge, R., Clarke, C., Whyte, D., Kirschner, K., Jackstadt, R., Norman, J., Carlin, L. M., Campbell, A. D., Sansom, O. J., Steele, C. W. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4, pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319)
Mahmood, M., Liu, E. M., Shergold, A. L., Tolla, E., Tait-Mulder, J., Huerta Uribe, A., Shokry, E., Young, A. L., Lilla, S., Kim, M., Park, T., Boscenco, S., Manchon, J. L., Rodríguez-Antona, C., Walters, R. C., Springett, R. J., Blaza, J. N., Mitchell, L., Blyth, K., Zanivan, S., Sumpton, D., Roberts, E. W., Reznik, E., Gammage, P. A. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, (doi: 10.1038/s43018-023-00721-w)
Skalka, G. L., Tsakovska, M., Murphy, D. (2024) Kinase signaling adaptation supports dysfunctional mitochondria in disease. Frontiers in Molecular Biosciences, 11, (doi: 10.3389/fmolb.2024.1354682)
Cong, B., Cagan, R. L. (2024) Cell competition and cancer from Drosophila to mammals. Oncogenesis, 13, (doi: 10.1038/s41389-023-00505-y)
Catarata, M. J., Creamer, A. W., Dias, M., Toland, S., Chaabouni, M., Verbeke, K., Vieira Naia, J., Hassan, M., Naidu, S. B., Lynch, G. A., Blyth, K. G., Rahman, N. M., Hardavella, G. (2024) ERS International Congress 2023: highlights from the Thoracic Oncology Assembly. ERJ Open Research, 10, (doi: 10.1183/23120541.00860-2023)
Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210)
Kidd, A. C., Cowell, G. W., Martin, G. A., Ferguson, J., Fennell, D. A., Evison, M., Blyth, K. G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42, (doi: 10.1016/j.ctarc.2024.100856)
2023
Neilson, L. J., Cartwright, D., Risteli, M., Jokinen, E. M., McGarry, L., Sandvik, T., Nikolatou, K., Hodge, K., Atkinson, S., Vias, M., Kay, E. J., Brenton, J. D., Carlin, L. M., Bryant, D. M., Salo, T., Zanivan, S. (2023) Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment. Matrix Biology Plus, 19-20, (doi: 10.1016/j.mbplus.2023.100136)
Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7, pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)
Lewis, D. Y. (2023) Multiplexing autoradiography. Humana
Ferguson, J., Tsim, S., Kelly, C., Alexander, L., Shad, S., Neilly, M., Tate, M., Zahra, B., Saleh, M., Cowell, G., Banks, E., Grundy, S., Corcoran, J., Downer, N., Stanton, A., Evison, M., Rahman, N., Maskell, N., Blyth, K. (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10, (doi: 10.1136/bmjresp-2023-001771)
Hewitt, R. J., Puttur, F., Gaboriau, D. C.A., Fercoq, F., Fresquet, M., Traves, W. J., Yates, L. L., Walker, S. A., Molyneaux, P. L., Kemp, S. V., Nicholson, A. G., Rice, A., Roberts, E., Lennon, R., Carlin, L. M., Byrne, A. J., Maher, T. M., Lloyd, C. M. (2023) Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis. Nature Communications, 14, (doi: 10.1038/s41467-023-41621-y)
Dzien, P., Mackintosh, A., Malviya, G., Johnson, E., Soloviev, D., Brown, G., Huerta Uribe, A., Nixon, C., Lyons, S. K., Maddocks, O., Blyth, K., Lewis, D. (2023) Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo. Cancer and Metabolism, 11, (doi: 10.1186/s40170-023-00314-2)
Young, A. L., Lorimer, T., Al-Khalidi, S. K., Roberts, E. W. (2023) De novo priming: driver of immunotherapy responses or epiphenomenon? Essays In Biochemistry, 67, pp. 929-939. (doi: 10.1042/EBC20220244)
Nikolatou, K., Sandilands, E., Román-Fernández, A., Cumming, E. M., Freckmann, E., Lilla, S., Buetow, L., McGarry, L., Neilson, M., Shaw, R., Strachan, D., Miller, C., Huang, D. T., Mcneish, I. A., Norman, J. C., Zanivan, S., Bryant, D. M. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, (doi: 10.15252/embj.2023113987)
Ferguson, K., Neilson, M., Mercer, R., King, J., Marshall, K., Welch, H., Tsim, S., Rahman, N. M., Maskell, N. A., Evison, M., Blyth, K. G. (2023) Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance. BMJ Open, 13, (doi: 10.1136/bmjopen-2022-067780)
Staedtke, V., Topilko, P., Le, L. Q., Grimes, K., Largaespada, D. A., Cagan, R. L., Steensma, M. R., Stemmer-Rachamimov, A., Blakeley, J. O., Rhodes, S. D., Ly, I., Romo, C. G., Lee, S. Y., Serra, E. (2023) Existing and developing preclinical models for neurofibromatosis type 1−related cutaneous neurofibromas. Journal of Investigative Dermatology, 143, pp. 1378-1387. (doi: 10.1016/j.jid.2023.01.042)
Pirillo, C., Al Khalidi, S., Sims, A., Devlin, R., Zhao, H., Pinto, R., Jasim, S., Shearer, P. A., Shergold, A. L., Donnelly, H., Bravo-Blas, A., Loney, C., Perona-Wright, G., Hutchinson, E., Roberts, E. W. (2023) Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Science Immunology, 8, (doi: 10.1126/sciimmunol.adg8249)
Whyte, D., Skalka, G., Walsh, P., Wilczynska, A., Paul, N. R., Mitchel, C., Nixon, C., Clarke, W., Bushell, M., Morton, J. P., Murphy, D. J., Muthalagu, N. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, 17, pp. 1212-1227. (doi: 10.1002/1878-0261.13425)
Farahmand, P., Gyuraszova, K., Rooney, C., Raffo-Iraolagoitia, X. L., Jayasekera, G., Hedley, A., Johnson, E., Chernova, T., Malviya, G., Hall, H., Monteverde, T., Blyth, K., Duffin, R., Carlin, L. M., Lewis, D., le Quesne, J., MacFarlane, M., Murphy, D. J. (2023) Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Frontiers in Toxicology, 5, (doi: 10.3389/ftox.2023.1200650)
Hatthakarnkul, P., Ammar, A., Pennel, K. A.F., Officer-Jones, L., Cusumano, S., Quinn, J. A., Matly, A. A. M., Alexander, P. G., Hay, J., Andersen, D., Lynch, G., Van Wyk, H. C., Maka, N., McMillan, D. C., Le Quesne, J., Thuwajit, C., Edwards, J. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14, pp. 1837-1847. (doi: 10.7150/jca.83910)
Brown, G., Soloviev, D., Lewis, D. Y. (2023) Radiosynthesis and analysis of (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid. Molecular Imaging and Biology, 25, pp. 586-595. (doi: 10.1007/s11307-022-01793-3)
Zhang, H., AbdulJabbar, K., Moore, D. A., Akarca, A., Enfield, K., Jamal-Hanjani, M., Raza, S. E. A., Veeriah, S., Salgado, R., McGranahan, N., Le Quesne, J., Swanton, C., Marafioti, T., Yuan, Y. (2023) Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma. Cancer Research, 83, pp. 1410-1425. (doi: 10.1158/0008-5472.CAN-22-2589)
May, S., Muller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Voorde, J. V., Officer-Jones, L., Ballantyne, F., Powley, I. R., Drake, T. M., Kiourtis, C., Keith, A., Rocha, A. S., Tardito, S., Sumpton, D., Le Quesne, J., Bushell, M., Sansom, O. J., Bird, T. G. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78, pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009)
Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30, pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w)
Ng, K. W. et al. (2023) Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature, 616, pp. 563-573. (doi: 10.1038/s41586-023-05771-9)
Martínez-Ruiz, C. et al. (2023) Genomic–transcriptomic evolution in lung cancer and metastasis. Nature, 616, pp. 543-552. (doi: 10.1038/s41586-023-05706-4)
Frankell, A. M. et al. (2023) The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 616, pp. 525-533. (doi: 10.1038/s41586-023-05783-5)
Al Bakir, M. et al. (2023) The evolution of non-small cell lung cancer metastases in TRACERx. Nature, 616, pp. 534-542. (doi: 10.1038/s41586-023-05729-x)
Abbosh, C. et al. (2023) Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature, 616, pp. 553-562. (doi: 10.1038/s41586-023-05776-4)
Hill, W. et al. (2023) Lung adenocarcinoma promotion by air pollutants. Nature, 616, pp. 159-167. (doi: 10.1038/s41586-023-05874-3)
Al-Sawaf, O. et al. (2023) Body composition and lung cancer-associated cachexia in TRACERx. Nature Medicine, 29, pp. 846-858. (doi: 10.1038/s41591-023-02232-8)
Alizzi, Z., Roxburgh, P., Cartwright, D., McLaren, A., Park, S., Jones, R., Greening, S., Hudson, E., Green, C., Gray, S., Khalique, S., Karteris, E., Hall, M. (2023) Description of a retrospective cohort of epithelial ovarian cancer patients with brain metastases: evaluation of the role of PARP inhibitors in this setting. Journal of Clinical Medicine, 12, (doi: 10.3390/jcm12072497)
Karasaki, T. et al. (2023) Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature Medicine, 29, pp. 833-845. (doi: 10.1038/s41591-023-02230-w)
Katz, S. I., Straus, C. M., Roshkovan, L., Blyth, K. G., Frauenfelder, T., Gill, R. R., Lalezari, F., Erasmus, J., Nowak, A. K., Gerbaudo, V. H., Francis, R. J., Armato, S. G. (2023) Considerations for imaging of malignant pleural mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Journal of Thoracic Oncology, 18, pp. 278-298. (doi: 10.1016/j.jtho.2022.11.018)
Villar, V. H., Allega, M. F., Deshmukh, R., Ackermann, T., Nakasone, M. A., Vande Voorde, J., Drake, T. M., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E. H., Vereecke, L., Jans, M., Blancke, G., Murphy, D. J., Huang, D. T., Lewis, D. Y., Bird, T. G., Sansom, O. J., Blyth, K., Sumpton, D., Tardito, S. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19, pp. 292-300. (doi: 10.1038/s41589-022-01154-9)
Schmidt, T., Dąbrowska, A., Waldron, J. A., Hodge, K., Koulouras, G., Gabrielsen, M., Munro, J., Tack, D. C., Harris, G., McGhee, E., Scott, D., Carlin, L. M., Huang, D., Le Quesne, J., Zanivan, S., Wilczynska, A., Bushell, M. (2023) eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51, pp. 1859-1879. (doi: 10.1093/nar/gkad030)
Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10, (doi: 10.1136/openhrt-2022-002192)
2022
Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9, (doi: 10.1126/sciadv.abq1858)
Soloviev, D., Dzien, P., Mackintosh, A., Malviya, G., Brown, G., Lewis, D. (2022) High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET. EJNMMI Radiopharmacy and Chemistry, 7, (doi: 10.1186/s41181-022-00185-w)
Kidd, A. C., Anderson, O., Cowell, G. W., Weir, A. J., Voisey, J. P., Evison, M., Tsim, S., Goatman, K. A., Blyth, K. G. (2022) Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria. Thorax, 77, pp. 1251-1259. (doi: 10.1136/thoraxjnl-2021-217808)
Sims, A., Tornaletti, L. B., Jasim, S., Pirillo, C., Devlin, R., Hirst, J. C., Loney, C., Wojtus, J., Sloan, E., Thorley, L., Boutell, C., Roberts, E., Hutchinson, E. (2022) Superinfection exclusion creates spatially distinct influenza virus populations. PLoS Biology, 21, (doi: 10.1371/journal.pbio.3001941)
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2021
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2020
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Duffy, C., Kidd, A. C., Francis, S., Tsim, S., McNaughton, L., Ferguson, K., Ferguson, J., Rodgers, G., Mcgroarty, C., Sayer, R., Blyth, K. G. (2020) Chest drain aerosol generation in COVID-19 and emission reduction using a simple anti-viral filter. BMJ Open, 7, (doi: 10.1136/bmjresp-2020-000710)
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2019
Waldron, J. A., Tack, D. C., Ritchey, L. E., Gillen, S. L., Wilczynska, A., Turro, E., Bevilacqua, P. C., Assmann, S. M., Bushell, M., Le Quesne, J. (2019) mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Genome Biology, 20, (doi: 10.1186/s13059-019-1901-2)
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Sarosiek, K. A., Fraser, C., Muthalagu, N., Bhola, P. D., Chang, W., McBrayer, S. K., Cantlon, A., Fisch, S., Golomb-Mello, G., Ryan, J. A., Deng, J., Jian, B., Corbett, C., Goldenberg, M., Madsen, J. R., Liao, R., Walsh, D., Sedivy, J., Murphy, D. J., Carrasco, D. R., Robinson, S., Moslehi, J., Letai, A. (2017) Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell, 31, pp. 142-156. (doi: 10.1016/j.ccell.2016.11.011)
Iltzsche, F., Simon, K., Stopp, S., Pattschull, G., Francke, S., Wolter, P., Hauser, S., Murphy, D.J., Garcia, P., Rosenwald, A., Gaubatz, S. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, 36, pp. 110-121. (doi: 10.1038/onc.2016.181)
Tsim, S., Stobo, D. B., Alexander, L., Kelly, C., Blyth, K. G. (2017) The diagnostic performance of routinely acquired and reported computed tomography imaging in patients presenting with suspected pleural malignancy. Lung Cancer, 103, pp. 38-43. (doi: 10.1016/j.lungcan.2016.11.010)
Carter, L., Rothwell, D. G., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., Hodgkinson, C. L., Morris, K., Priest, L., Carter, M., Miller, C., Hughes, A., Blackhall, F., Dive, C., Brady, G. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23, pp. 114-119. (doi: 10.1038/nm.4239)
Draper, J. E., Sroczynska, P., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130, pp. 271-284. (doi: 10.1182/blood-2016-06-723635)
2016
Bangi, E., Murgia, C., Teague, A. G.S., Sansom, O. J., Cagan, R. L. (2016) Functional exploration of colorectal cancer genomes using Drosophila. Nature Communications, 7, (doi: 10.1038/ncomms13615)
Williamson, S. C. et al. (2016) Vasculogenic mimicry in small cell lung cancer. Nature Communications, 7, (doi: 10.1038/ncomms13322)
Flint, T. R., Janowitz, T., Connell, C. M., Roberts, E. W., Denton, A. E., Coll, A. P., Jodrell, D. I., Fearon, D. T. (2016) Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metabolism, 24, pp. 672-684. (doi: 10.1016/j.cmet.2016.10.010)
Tsim, S., Kelly, C., Alexander, L., McCormick, C., Thomson, F., Woodward, R., Foster, J. E., Stobo, D. B., Paul, J., Maskell, N. A., Chalmers, A., Blyth, K. G. (2016) Diagnostic and prognostic biomarkers in the rational assessment of mesothelioma (DIAPHRAGM) study: protocol of a prospective, multi-centre, observational study. BMJ Open, 6, (doi: 10.1136/bmjopen-2016-013324)
Armato, S. G., Blyth, K. G., Keating, J. J., Katz, S., Tsim, S., Coolen, J., Gudmundsson, E., Opitz, I., Nowak, A. K. (2016) Imaging in pleural mesothelioma: a review of the 13th International Conference of the International Mesothelioma Interest Group. (doi: 10.1016/j.lungcan.2016.09.003)
Heinzmann, K., Honess, D. J., Lewis, D. Y., Smith, D.-M., Cawthorne, C., Keen, H., Heskamp, S., Schelhaas, S., Witney, T. H., Soloviev, D., Williams, K. J., Jacobs, A. H., Aboagye, E. O., Griffiths, J. R., Brindle, K. M. (2016) The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Research, 6, (doi: 10.1186/s13550-016-0218-3)
Roberts, E. W., Broz, M. L., Binnewies, M., Headley, M. B., Nelson, A. E., Wolf, D. M., Kaisho, T., Bogunovic, D., Bhardwaj, N., Krummel, M. F. (2016) Critical role for CD103 + /CD141 + dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma. Cancer Cell, 30, pp. 324-336. (doi: 10.1016/j.ccell.2016.06.003)
Memon, D., Dawson, K., Smowton, C. S., Xing, W., Dive, C., Miller, C. J. (2016) Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response. npj Genomic Medicine, 1, (doi: 10.1038/npjgenmed.2016.20)
Carter, L. R., Rothwell, D. G., Leong, H., Li, Y., Burt, D. J., Antonello, J., Hodgkinson, C., Morris, K., Franklin, L., Miller, C. J., Blackhall, F., Dive, C., Brady, G. (2016) Abstract 3155: Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells. (doi: 10.1158/1538-7445.AM2016-3155)
Morrow, C.J., Trapani, F., Metcalf, R.L., Bertolini, G., Hodgkinson, C.L., Khandelwal, G., Kelly, P., Galvin, M., Carter, L., Simpson, K.L., Williamson, S., Wirth, C., Simms, N., Frankliln, L., Frese, K.K., Rothwell, D.G., Nonaka, D., Miller, C.J., Brady, G., Blackhall, F.H., Dive, C. (2016) Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Annals of Oncology, 27, pp. 1155-1160. (doi: 10.1093/annonc/mdw122)
Tape, C. J., Ling, S., Dimitriadi, M., McMahon, K. M., Worboys, J. D., Leong, H. S., Norrie, I. C., Miller, C., Poulogiannis, G., Lauffenburger, D. A., Jørgensen, C. (2016) Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 165, pp. 910-920. (doi: 10.1016/j.cell.2016.03.029)
Rothwell, D. G., Smith, N., Morris, D., Leong, H. S., Li, Y., Hollebecque, A., Ayub, M., Carter, L., Antonello, J., Franklin, L., Miller, C., Blackhall, F., Dive, C., Brady, G. (2016) Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample. Molecular Oncology, 10, pp. 566-574. (doi: 10.1016/j.molonc.2015.11.006)
Headley, M. B., Bins, A., Nip, A., Roberts, E. W., Looney, M. R., Gerard, A., Krummel, M. F. (2016) Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature, 531, pp. 513-517. (doi: 10.1038/nature16985)
Cagan, R., Gottlieb, E. (2016) In memory of Marcos Vidal (1974-2016) Disease Models and Mechanisms, 9, pp. 233-233. (doi: 10.1242/dmm.024612)
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Marusiak, A. A., Stephenson, N. L., Baik, H., Trotter, E. W., Li, Y., Blyth, K., Mason, S., Chapman, P., Puto, L. A., Read, J. A., Brassington, C., Pollard, H. K., Phillips, C., Green, I., Overman, R., Collier, M., Testoni, E., Miller, C.J., Hunter, T., Sansom, O.J., Brognard, J. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76, pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t)
Grimes, H. L., Draper, J. E., Sroczynska, P., Tsoulaki, O., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2016) RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis. PLoS Genetics, 12, (doi: 10.1371/journal.pgen.1005814)
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Thambyrajah, R., Mazan, M., Patel, R., Moignard, V., Stefanska, M., Marinopoulou, E., Li, Y., Lancrin, C., Clapes, T., Möröy, T., Robin, C., Miller, C., Cowley, S., Göttgens, B., Kouskoff, V., Lacaud, G. (2016) GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology, 18, pp. 21-32. (doi: 10.1038/ncb3276)
Roberts, E.W., Denton, A.E., Fearon, D.T. (2016) Roles of stromal cells in the immune system. Elsevier
• Use of fly and mammalian models to explore therapeutic mechanisms & develop new compounds for clinical trials to improve treatment for cancer patients.
• Generating highly complex Drosophila models to explore the biology of cancer therapeutics, including for thyroid, colorectal, lung, salivary gland, and breast cancers, used as the start of an integrated approach towards therapeutics.
• These models are designed to capture the genomic complexity of individual human colorectal, thyroid, lung, and breast cancer patients.
• To develop new therapeutic leads that improve on vandetanib for MTC—a similarly rare and deadly disease that is inherited in 25% of patients—we used a fly model to identify the FDA approved drug sorafenib as showing moderate efficacy. We then used a new platform developed by the Dar and Cagan laboratories to create sorafenib analogs (‘sorafelogs’) that (i) show excellent preclinical efficacy while (ii) retaining the druggable properties of sorafenib.
• Developing new generation lead therapeutic compounds using a novel fly/chemistry drug development platform.
• Utilising a combination of classical molecular and quantitative microscopic imaging techniques to ask questions about solid tumour biology. What can be observed in fully contextualised tumour tissue, the ‘natural environment’ of the malignant cell? How do malignant cells interact with the microenvironment of the tumour? What naturally selected strategies can be identified at a cellular scale in human and mouse tumour tissues? Main interests are across 3 areas: - The dysregulation of mRNA translation in tumour cells and stroma, and how this reprogramming of the genome facilitates the malignant programme at the cellular level - The refinement and development of highly multiplexed microscopic imaging methods to reveal additional levels of single-cellular detail in spatial context (e.g. quantity and subcellular localisation of multiple gene products at mRNA and protein levels) - The improvement of biomarkers for the prediction of personalised treatment efficacy and patient prognostication.
• Oncogene-induced vulnerabilities: Oncogenic mutations do more than simply drive unscheduled proliferation – they requisition entire suites of cellular programmes that impinge upon almost every aspect of cellular function. Our overarching hypothesis is that, as tumours evolve, some of these oncogene-induced alterations will be selectively required by cancer cells to maintain viability. We have used a synthetic lethal approach to identify kinases required by cells that overexpress c-Myc. Intriguingly, a specifically developed screen identified a number of metabolic regulators, suggesting that Myc-driven tumours may be particularly sensitive to disruption of metabolic checkpoints. This suggests that pharmacological suppression of Ark5/AMPK may have broad therapeutic potential against a spectrum of human cancers. Furthermore, we have developed several conditional transgenic mouse models of cancer that enable us to humanely track the entire course of early disease through tumour initiation and progression in situ. The use of inducible RNAi transgenic technology will now enable us to accurately model therapeutic intervention against existing tumours in mice with a higher degree of genetic “on-target” certainty than is typically afforded by nascent pharmacological agents. The use of these models to compliment cell culture-based approaches is essential for a complete mechanistic understanding of the many processes involved in cancer as well as for more realistic pre-clinical evaluation of candidate therapies.
• Molecular imaging can non-invasively measure the spatial and temporal dynamics of cancer metabolism. Research in our group uses state-of-the art PET/MR imaging, metabolomics and genomics to understand the drivers and consequences of metabolic heterogeneity in living tumours. The goal of this research is to develop methods to non-invasively classify tumours and to direct cancer treatment.
• The Translational Molecular Imaging (TMI) centre advances novel imaging technologies and acts as a shared resource for Scotland Institute and Glasgow Cancer Centre researchers serving as a hub for emerging imaging research and technology. The state-of-the-art facilities and equipment include access to a GE cyclotron, dedicated research radiosynthesizers, a small-animal PET/MRI facility and two clinical GE Discovery Time-of-Flight PET/CT scanners. The TMI drives collaborative imaging research across this network making the best available imaging technologies and expertise available to all preclinical and clinical researchers. The focus is on developing and applying innovative imaging technologies such as new PET radiotracers and MRI methodology, which can aid in the visualisation, measurement and understanding of cancer biology. The goal is to answer basic scientific questions and clinically translate novel imaging technology for improving the molecular diagnosis of cancer, a current area of unmet need.