Head/Neck/Thyroid
Research by Glasgow Head & Neck Cancer Research Group (GLAHNC), with the primary aim of increasing research into head & neck cancer in Glasgow.
Staff
Publications
2025
Hall-Younger, E., Tait, S. W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94, (doi: 10.1016/j.ceb.2025.102510)
Bone, M., Schreyer, D., Treanor-Taylor, M., Proby, C., Harwood, C., Leigh, I. M., Bailey, P., Inman, G. (2025) The landscape of long non-coding RNA during cSCC progression. British Journal of Dermatology,
Hurley, R., Osbourne, J., Inman, G. J., Conway, D. I., Paterson, C., Douglas, C. (2025) Pre-treatment serum prognostic scores and survival in curatively treated laryngeal cancer. Laryngoscope Investigative Otolaryngology,
Creaney, G. et al. (2025) Advanced stage head and neck cancer diagnosis: HEADSpAcE consortium health systems benchmarking survey. Head and Neck, (doi: 10.1002/hed.28094)
White, S. E., Schwartze, T. A., Mukundan, A., Schoenherr, C., Singh, S. P., van Dinther, M., Cunningham, K. T., White, M. P. J., Campion, T., Pritchard, J., Hinck, C. S., ten Dijke, P., Inman, G. J., Maizels, R. M., Hinck, A. P. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16, (doi: 10.1038/s41467-025-56954-z)
Hurley, R., Paterson, C., Conway, D. I., Inman, G. J., Douglas, C. M. (2025) Laryngeal cancer in the West of Scotland 2014–2020: trends and survival in a cohort of 867 patients. Laryngoscope, (doi: 10.1002/lary.31992)
Donachie, M., Horackiewicz, J., Philp, N., Slim, M. A. M., Hurley, R. (2025) Oropharyngeal squamous cell carcinoma in the West of Scotland: a retrospective analysis of 1001 patients from 2012 to 2020. Clinical Otolaryngology,
2024
Singh, S. P., Smyth, D. J., Cunningham, K. T., Mukundan, A., Byeon, C.-H., Hinck, C. S., White, M. P.J., Ciancia, C., Wąsowska, N., Sanders, A., Jin, R., White, R. F., Lilla, S., Zanivan, S., Schoenherr, C., Inman, G., van Dinther, M., ten Dijke, P., Hinck, A. P., Maizels, R. M. (2024) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, (doi: 10.1038/s44319-024-00323-2)
McCann, C., Hurley, R., McGovern, J., Knight, K., Rattray, N. J.W., Douglas, C. M. (2024) Frailty and the survival outcomes of patients with laryngeal squamous cell cancer. Head and Neck, (doi: 10.1002/hed.27951)
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, (doi: 10.1038/s41556-024-01543-3)
Smith, C. D.L., McMahon, A. D., Purkayastha, M., Creaney, G., Clements, K., Inman, G. J., Bhatti, L. A., Douglas, C. M., Paterson, C., Conway, D. I. (2024) Head and neck cancer incidence is rising but the sociodemographic profile is unchanging: a population epidemiological study (2001-2020) BJC Reports, 2, (doi: 10.1038/s44276-024-00089-z)
Strathearn, L. S., Spender, L. C., Schoenherr, C., Mason, S., Edwards, R., Blyth, K., Inman, G. (2024) C1orf106 (INAVA) is a SMAD3-dependent TGF-β target gene that promotes clonogenicity and correlates with poor prognosis in breast cancer. Cells, 13, (doi: 10.3390/cells13181530)
Smith, C. D.L., McMahon, A. D., Lyall, D. M., Goulart, M., Inman, G., Ross, A., Gormley, M., Dudding, T., Macfarlane, G. J., Robinson, M., Richiardi, L., Serraino, D., Polesel, J., Canova, C., Ahrens, W., Healy, C. M., Lagiou, P., Holcatova, I., Alemany, L., Znoar, A., Waterboer, T., Brennan, P., Virani, S., Conway, D. I. (2024) Development and external validation of a head and neck cancer risk prediction model. Head and Neck, 46, pp. 2261-2273. (doi: 10.1002/hed.27834)
Glover, H. L., Schreiner, A., Dewson, G., Tait, S. W.G. (2024) Mitochondria and cell death. Nature Cell Biology, 26, pp. 1434-1446. (doi: 10.1038/s41556-024-01429-4)
Ahmed Hassan Elshiekh, A., Tait, S. W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18, pp. 1054-1057. (doi: 10.1002/1878-0261.13627)
Vens, C., van Luijk, P., Vogelius, R.I., El Naqa, I., Humbert-Vidan, L., von Neubeck, C., Gomez-Roman, N., Bahn, E., Brualla, L., Böhlen, T.T., Ecker, S., Koch, R., Handeland, A., Pereira, S., Possenti, L., Rancati, T., Todor, D., Vanderstraeten, B., Van Heerden, M., Ullrich, W., Jackson, M., Alber, M., Marignol, L., ESTRO DREAM team, (2024) A joint physics and radiobiology DREAM team vision - towards better response prediction models to advance radiotherapy. Radiotherapy and Oncology, 196, (doi: 10.1016/j.radonc.2024.110277)
Ahmadian, M., Bodalal, Z., van der Hulst, H. J., Vens, C., Karssemakers, L. H.E., Bogveradze, N., Castagnoli, F., Landolfi, F., Hong, E. K., Gennaro, N., Pizzi, A. D., Beets-Tan, R. G.H., van den Brekel, M. W.M., Castelijns, J. A. (2024) Overcoming data scarcity in radiomics/radiogenomics using synthetic radiomic features. Computers in Biology and Medicine, 174, (doi: 10.1016/j.compbiomed.2024.108389)
Homer, J. J. et al. (2024) Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition. Journal of Laryngology and Otology, 138, pp. S1-S224. (doi: 10.1017/S0022215123001615)
Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, M., Murphy, D. J., Huang, D. T., Zanivan, S., Tait, S. W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43, pp. 904-930. (doi: 10.1038/s44318-024-00044-1)
Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210)
2023
Wang, J., Harwood, C. A., Bailey, E., Bewicke-Copley, F., Anene, C. A., Thomson, J., Qamar, M. J., Laban, R., Nourse, C., Schoenherr, C., Treanor-Taylor, M., Healy, E., Lai, C., Craig, P., Moyes, C., Rickaby, W., Martin, J., Proby, C., Inman, G. J., Leigh, I. M. (2023) Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. Journal of the American Academy of Dermatology, 89, pp. 1159-1166. (doi: 10.1016/j.jaad.2023.08.012)
Victorelli, S. et al. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622, pp. 627-636. (doi: 10.1038/s41586-023-06621-4)
Van der Hulst, H. J., Jansen, R. W., Vens, C., Bos, P., Schats, W., De Jong, M. C., Martens, R. M., Bodalal, Z., Beets-Tan, R. G. H., Van den Brekel, M. W. M., De Graaf, P., Castelijns, J. A. (2023) The prediction of biological features using magnetic resonance imaging in head and neck squamous cell carcinoma: a systematic review and meta-analysis. Cancers, 15, (doi: 10.3390/cancers15205077)
Lim, A. E., Hurley, R., Slim, M. A. M., Melia, L. (2023) A narrative review of flutamide in juvenile nasopharyngeal angiofibroma. Indian Journal of Otolaryngology and Head and Neck Surgery, 75, pp. 2707-2712. (doi: 10.1007/s12070-023-03581-z)
Bailey, P., Ridgway, R. L., Cammareri, P., Treanor-Taylor, M., Bailey, U.-M., Schoenherr, C., Bone, M., Schreyer, D., Purdie, K., Thomson, J., Rickaby, W., Jackstadt, R., Campbell, A. D., Dimonitsas, E., Stratigos, A. J., Arron, S. T., Wang, J., Blyth, K., Proby, C. M., Harwood, C. A., Sansom, O. J., Leigh, I. M., Inman, G. J. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, (doi: 10.1038/s41467-023-40822-9)
Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30, pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w)
Marchi, S., Guilbaud, E., Tait, S. W.G., Yamazaki, T., Galluzzi, L. (2023) Mitochondrial control of inflammation. Nature Reviews Immunology, 23, pp. 159-173. (doi: 10.1038/s41577-022-00760-x)
Heilig, R., Lee, J., Tait, S. W.G. (2023) Mitochondrial DNA in cell death and inflammation. Biochemical Society Transactions, 51, pp. 457-472. (doi: 10.1042/BST20221525)
Koessinger, D., Novo, D., Koessinger, A., Campos, A., Peters, J., Dutton, L., Paschke, P., Zerbst, D., Moore, M., Mitchell, L., Neilson, M., Stevenson, K., Chalmers, A., Tait, S., Birch, J., Norman, J. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5, (doi: 10.1093/noajnl/vdad067)
2022
Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, (doi: 10.1038/s41467-022-35134-3)
Smith, C. D.L., McMahon, A. D., Ross, A., Inman, G. J., Conway, D. I. (2022) Risk prediction models for head and neck cancer: a rapid review. Laryngoscope Investigative Otolaryngology, 7, pp. 1893-1908. (doi: 10.1002/lio2.982)
Creaney, G., McMahon, A. D., Ross, A. J., Bhatti, L. A., Paterson, C., Conway, D. I. (2022) Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018) British Dental Journal, 233, pp. 787-793. (doi: 10.1038/s41415-022-5151-4)
Gormley, M., Creaney, G., Schache, A., Ingarfield, K., Conway, D. I. (2022) Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. British Dental Journal, 233, pp. 780-786. (doi: 10.1038/s41415-022-5166-x)
Vringer, E., Tait, S. W.G. (2022) Mitochondria and cell death-associated inflammation. Cell Death and Differentiation, 30, pp. 304-312. (doi: 10.1038/s41418-022-01094-w)
Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29, pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3)
Kalkavan, H., Chen, M. J., Crawford, J. C., Quarato, G., Fitzgerald, P., Tait, S. W.G., Goding, C. R., Green, D. R. (2022) Sublethal cytochrome c release generates drug-tolerant persister cells. Cell, 185, pp. 3356-3374.e22. (doi: 10.1016/j.cell.2022.07.025)
van der Wiel, A. M. A., Schuitmaker, L., Cong, Y., Theys, J., Van Hoeck, A., Vens, C., Lambin, P., Yaromina, A., Dubois, L. J. (2022) Homologous recombination deficiency scar: mutations and beyond—implications for precision oncology. Cancers, 14, (doi: 10.3390/cancers14174157)
Zacharioudakis, E., Agianian, B., Kumar MV, V., Biris, N., Garner, T. P., Rabinovich-Nikitin, I., Ouchida, A. T., Margulets, V., Nordstrøm, L. U., Riley, J. S., Dolgalev, I., Chen, Y., Wittig, A. J. H., Pekson, R., Mathew, C., Wei, P., Tsirigos, A., Tait, S. W.G., Kirshenbaum, L. A., Kitsis, R. N., Gavathiotis, E. (2022) Modulating mitofusins to control mitochondrial function and signaling. Nature Communications, 13, (doi: 10.1038/s41467-022-31324-1)
Ahmed, A., Giampazolias, E., Patel, R., Leung, H., Tait, S. W.G. (2022) Caspase-independent cell death as a novel therapy for advanced prostate cancer.
Cao, K., Riley, J. S., Heilig, R., Montes-Gómez, A. E., Vringer, E., Berthenet, K., Cloix, C., Elmasry, Y., Spiller, D. G., Ichim, G., Campbell, K. J., Gilmore, A. P., Tait, S. W.G. (2022) Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Developmental Cell, 57, pp. 1211-1225.e6. (doi: 10.1016/j.devcel.2022.03.019)
Tait, S. W.G. (2022) Killing cells using light (activated) sabers. Journal of Cell Biology, 221, (doi: 10.1083/jcb.202205018)
Fanfone, D., Wu, Z., Mammi, J., Berthenet, K., Neves, D., Weber, K., Halaburkova, A., Virard, F., Bunel, F., Jamard, C., Hernandez-Vargas, H., Tait, S. W.G., Hennino, A., Ichim, G. (2022) Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. eLife, 11, (doi: 10.7554/eLife.73150)
2021
Rabas, N., Palmer, S., Mitchell, L., Ismail, S., Gohlke, A., Riley, J. S., Tait, S. W.G., Gammage, P., Lemgruber Soares, L., MacPherson, I. R., Norman, J. C. (2021) PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. Journal of Cell Biology, 220, (doi: 10.1083/jcb.202006049)
Johnson, S. A., Ormsby, M. J., Wessel, H., Hulme, H., Bravo-Blas, A., McIntosh, A., Mason, S., Coffelt, S., Tait, S. W.G., Mcl. Mowat, A., Milling, S., Blyth, K., Wall, D. M. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51, pp. 3228-3238. (doi: 10.1002/eji.202048913)
Hollis, R. L., Stillie, L. J., Hopkins, S., Bartos, C., Churchman, M., Rye, T., Nussey, F., Fegan, S., Nirsimloo, R., Inman, G. J., Herrington, C. S., Gourley, C. (2021) Clinicopathological determinants of recurrence risk and survival in mucinous ovarian carcinoma. Cancers, 13, (doi: 10.3390/cancers13225839)
Bock, F. J., Sedov, E., Koren, E., Koessinger, A. L., Cloix, C., Zerbst, D., Athineos, D., Anand, J., Campbell, K. J., Blyth, K., Fuchs, Y., Tait, S. W.G. (2021) Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death. Nature Communications, 12, (doi: 10.1038/s41467-021-26613-0)
Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)
Campbell, K. J., Mason, S. M., Winder, M. L., Willemsen, R. B.E., Cloix, C., Lawson, H., Rooney, N., Dhayade, S., Sims, A. H., Blyth, K., Tait, S. W.G. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28, pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4)
Koessinger, A. L., Koessinger, D., Kinch, K., Martínez-Escardó, L., Paul, N. R., Elmasry, Y., Malviya, G., Cloix, C., Campbell, K. J., Bock, F. J., O'Prey, J., Stevenson, K., Nixon, C., Jackson, M. R., Ichim, G., Stewart, W., Blyth, K., Ryan, K. M., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)
Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, (doi: 10.1038/s41467-021-23717-5)
Roca-Portoles, A., Tait, S. W.G. (2021) Mitochondrial quality control: from molecule to organelle. Cellular and Molecular Life Sciences, 78, pp. 3853-3866. (doi: 10.1007/s00018-021-03775-0)
Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, (doi: 10.1038/s41467-020-20378-8)
Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy, 17, pp. 1-382. (doi: 10.1080/15548627.2020.1797280)
2020
Ahmed, A., Tait, S. W.G. (2020) Targeting immunogenic cell death in cancer. Molecular Oncology, 14, pp. 2994-3006. (doi: 10.1002/1878-0261.12851)
Stöhr, D., Schmid, J. O., Beigl, T. B., Mack, A., Maichl, D. S., Cao, K., Budai, B., Fullstone, G., Kontermann, R. E., Mürdter, T. E., Tait, S. W.G., Hagenlocher, C., Pollak, N., Scheurich, P., Rehm, M. (2020) Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death and Differentiation, 27, pp. 3037-3052. (doi: 10.1038/s41418-020-0559-3)
Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, (doi: 10.1038/s41598-020-72322-x)
Roca Portoles, A., Blanco, G., Sumpton, D., Cloix, C., Mullin, M., Mackay, G. M., O'Neill, K., Lemgruber Soares, L., Luo, X., Tait, S. W.G. (2020) Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell Death and Disease, 11, (doi: 10.1038/s41419-020-02867-2)
Wei, Q., Young, J., Holle, A., Li, J., Bieback, K., Inman, G., Spatz, J. P., Cavalcanti-Adam, E. A. (2020) Soft hydrogels for balancing cell proliferation and differentiation. ACS Biomaterials Science and Engineering, 6, pp. 4687-4701. (doi: 10.1021/acsbiomaterials.0c00854)
Wei, Q., Holle, A., Liu, J., Posa, F., Biagioni, F., Croci, O., Benk, A. S., Young, J., Noureddine, F., Deng, J., Zhang, M., Inman, G. J., Spatz, J. P., Campaner, S., Cavalcanti‐Adam, E. A. (2020) BMP‐2 signaling and mechanotransduction synergize to drive osteogenic differentiation via YAP/TAZ. Advanced Science, 7, (doi: 10.1002/advs.201902931)
Riley, J. S., Tait, S. W.G. (2020) Mitochondrial DNA in inflammation and immunity. EMBO Reports, 21, (doi: 10.15252/embr.201949799)
Bock, F. J., Tait, S. W.G. (2020) Mitochondria as multifaceted regulators of cell death. Nature Reviews Molecular Cell Biology, 21, pp. 85-100. (doi: 10.1038/s41580-019-0173-8)
2019
Orozco, S. L., Daniels, B. P., Yatim, N., Messmer, M. N., Quarato, G., Chen-Harris, H., Cullen, S. P., Snyder, A. G., Ralli-Jain, P., Frase, S., Tait, S. W.G., Green, D. R., Albert, M. L., Oberst, A. (2019) RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity. Cell Reports, 28, pp. 2275-2287.e5. (doi: 10.1016/j.celrep.2019.07.077)
Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G., Blyth, K., Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26, pp. 183-194. (doi: 10.1038/s41417-018-0039-9)
Vringer, E., Tait, S. W.G. (2019) Mitochondria and inflammation: cell death heats up. Frontiers in Cell and Developmental Biology, 7, (doi: 10.3389/fcell.2019.00100)
Badshah, I.I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., O'Shaughnessy, R.F.L. (2019) Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology, 180, pp. 1135-1149. (doi: 10.1111/bjd.17352)
Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L. S., Sansom, O. J., Barry, S. T., Inman, G. I. (2019) Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor β superfamily type 1 receptors. Molecular Pharmacology, 95, pp. 222-234. (doi: 10.1124/mol.118.112946)
Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J., Leigh, I. M. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20, (doi: 10.3390/ijms20143428)
Lopez, J., Tait, S. W.G. (2019) Application of mito-priming to generate BCL-2 addicted cells. Humana Press
Beaumatin, F., O'Prey, J., Barthet, V. J.A., Zunino, B., Parvy, J.-P., Bachmann, A. M., O'Prey, M., Kania, E., Gonzalez, P. S., Macintosh, R., Lao, L. Y., Nixon, C., Lopez, J., Long, J. S., Tait, S. W.G., Ryan, K. N. (2019) DRAM-1 is required for mTORC1 activation by facilitating lysosomal amino acid efflux. Molecular Cell, 76, pp. 163-176.E8. (doi: 10.1016/j.molcel.2019.07.021)
2018
Chauhan, D., Bartok, E., Gaidt, M. M., Bock, F. J., Herrmann, J., Seeger, J. M., Broz, P., Beckmann, R., Kashkar, H., Tait, S. W.G., Müller, R., Hornung, V. (2018) BAX/BAK induced apoptosis results in caspase-8 dependent IL-1β maturation in macrophages. Cell Reports, 25, pp. 2354-2368.e5. (doi: 10.1016/j.celrep.2018.10.087)
Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M., Leigh, I. M. (2018) The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications, 9, (doi: 10.1038/s41467-018-06027-1)
Riley, J. S., Quarato, G., Cloix, C., Lopez, J., O'Prey, J., Pearson, M., Chapman, J., Sesaki, H., Carlin, L. M., Passos, J. F., Wheeler, A. P., Oberst, A., Ryan, K. M., Tait, S. W.G. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37, (doi: 10.15252/embj.201899238)
Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Meijden, E. V. d., Inman, G. J., South, A. P., Leigh, I. M., Harwood, C. A. (2018) The role of human papillomaviruses and polyomaviruses in BRAF-inhibitor induced cutaneous squamous cell carcinoma and benign squamoproliferative lesions. Frontiers in Microbiology, 9, (doi: 10.3389/fmicb.2018.01806)
Campbell, K. J., Tait, S. W.J. (2018) Targeting BCL-2 regulated apoptosis in cancer. Open Biology, 8, (doi: 10.1098/rsob.180002)
Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J., Inman, G. j. (2018) Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma. Oncotarget, 9, pp. 14552-14566. (doi: 10.18632/oncotarget.24545)
Galluzzi, L. et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25, pp. 486-541. (doi: 10.1038/s41418-017-0012-4)
Campbell, K. J., Dhayade, S., Ferrari, N., Sims, A. H., Johnson, E., Mason, S. M., Dickson, A., Ryan, K. M., Kalna, G., Edwards, J., Tait, S. G.W., Blyth, K. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, (doi: 10.1038/s41419-017-0035-2)
Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D., Morrell, N. W. (2018) TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nature Communications, 8, (doi: 10.1038/ncomms14079)
Cao, K., Tait, S. W.G. (2018) Apoptosis and cancer: force awakens, phantom menace, or both? Elsevier
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2017
Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L.H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J., Sansom, O. J. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24, pp. 1681-1693. (doi: 10.1038/cdd.2017.92)
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Daniels, B. P., Snyder, A. G., Olsen, T. M., Orozco, S., Oguin III, T. H., Tait, S. W.G., Martinez, J., Gale, M., Loo, Y.-M., Oberst, A. (2017) RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation. Cell, 169, pp. 301-313.e11. (doi: 10.1016/j.cell.2017.03.011)
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Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W.G., Larue, L., Brakebusch, C. H., Insall, R. H., Machesky, L. M. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27, pp. 624-637. (doi: 10.1016/j.cub.2017.01.033)
Gutierrez, K. D., Davis, M. A., Daniels, B. P., Olsen, T. M., Ralli-Jain, P., Tait, S. W.G., Gale, Jr., M., Oberst, A. (2017) MLKL activation triggers NLRP3-mediated processing and release of IL-1β independently of gasdermin-D. Journal of Immunology, 198, pp. 2156-2164. (doi: 10.4049/jimmunol.1601757)
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2016
Pécot, J., Maillet, L., Le Pen, J., Vuillier, C., Trécesson, S. d. C., Fétiveau, A., Sarosiek, K. A., Bock, F. J., Braun, F., Letai, A., Tait, S. W.G., Gautier, F., Juin, P. P. (2016) Tight sequestration of BH3 proteins by BCL-xL at subcellular membranes contributes to apoptotic resistance. Cell Reports, 17, pp. 3347-3358. (doi: 10.1016/j.celrep.2016.11.064)
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• Exploration as to how to overcome cancers that are resistant to radiotherapy.
• Generation of models that inform response-based adaptations, individually optimized delivery and enable biological monitoring to provide decision support to clinicians.
• Investigation into role of cell death as a key tumour suppression mechanism, which is inhibited in order for cancer to develop.
• One of the 7 CRUK RadNet Glasgow focus groups. Main themes are translational studies, epidemiology studies focussed on inequalities and clinical trials with ongoing studies ranging from lab-based projects to population level studies. Research projects include:
- BARITONE – adaptive radiotherapy for advanced oropharyngeal cancer, using MRI scans during treatment - Radiotherapy failure after treatment of oropharyngeal cancer – most patients who have an HPV positive oropharyngeal cancer do very well after treatment however a small subset of these patients go on to develop recurrence of their cancer. This study will examine these patients in more detail to better understand why these patients develop recurrence.
- The impact of the covid pandemic on head and neck cancer – the pandemic had a significant impact on UK healthcare. This study aims to look at the impact on head and neck cancer patients. - HEADSpAcE – Head and Neck Cancer in South America and Europe. This EU funded, WHO-IARC coordinated study is building a multicentre cohort investigating factors associated with late-stage head and neck cancer.