Schools

Cartwright, D., Kidd, A. C., Ansel, S., Ascierto, M. L., Spiliopoulou, P. (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences,

Dobbin, S. J. H., Mangion, K., Berry, C., Roditi, G., Basak, S., McClure, J. D., Brooksbank, K., Sonecki, P., Sourbron, S., Evans, J., White, J., Welsh, P., Butler, E., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2025) Vascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging. Heart, (doi: 10.1136/heartjnl-2024-325535)

Thompson, J. J., MacLeod, N., Will, S., O'Rourke, F., McGovern, J., Roxburgh, C., Edwards, J., Dolan, R. D., McMillan, D. C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25, (doi: 10.1186/s12885-025-13426-3)

Elyan, B. M.P., Tan, B., Lambourg, E., McAllister, D. A., Jones, R. J., Lang, N. N., Mark, P. B., Lees, J. S., Bell, S. (2025) Incidence of cancer in people with CKD not requiring kidney replacement therapy: a systematic review and meta-analysis. Clinical Kidney Journal, (doi: 10.1093/ckj/sfaf084)

McMahon, R., O'Cathail, S., Steele, C., Nair, H., Platt, J. J., McMillan, D. C., Horgan, P. G., Roxburgh, C.S.D. (2025) Circulating markers of systemic inflammation, measured after completion of neoadjuvant therapy, associate with response in locally advanced rectal cancer. Diseases of the Colon and Rectum,

Saeed, R., McSorley, S., Cascales, A., McMillan, D. (2025) The prognostic/ predictive value of the systematic inflammatory response in patients receiving immunotherapy for non-small cell lung cancer: a systematic review and meta-analysis. BMC Cancer,

Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z)

van Duuren, P., Wieringa, T. H., Duiverman, M., Witjes, M., Snijder, A., Welisch, G., Smykowski, A., Keith, N. (2025) Reimagining Patient Involvement in Research. (doi: 10.17605/OSF.IO/5H9DY)

Dolan, R. D., Pennel, K., Thompson, J., McKenzie, M., Alexander, P., Richards, C., Black, D., Abbass, T., Maka, N., McGovern, J., Roseweir, A., McSorley, S. T., Horgan, P. G., Roxburgh, C., McMillan, D. C., Edwards, J. (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3, (doi: 10.1038/s44276-024-00119-w)

Bradley, N. A., Roxburgh, C. S.D., McMillan, D. C., Guthrie, G. J.K. (2025) A systematic review of the role of systemic inflammation-based prognostic scores in patients with abdominal aortic aneurysm. Surgeon, 23, pp. e1-e8. (doi: 10.1016/j.surge.2024.08.014)

Hartley, A., Galbraith, L. C.A., Shaw, R., Tibbo, A., Veeratterapillay, R., Wilson, L., Heer, R., Blyth, K., Leung, H., Ahmad, I. (2025) Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos. British Journal of Cancer, (doi: 10.1038/s41416-025-02944-3)

Pearson, L.-A., Petit, A.-P., Mendoza-Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P. K., Paul, M., Postis, V., Hu, X., Cowling, V. H., Gray, D. W. (2025) Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach. Biochemical Journal, (doi: 10.1042/bcj20240608)

Iwata, T., Ammar, A., Maka, N., Jawny, J., Hay, J., Martinelli, S., Officer-Jones, L., Le Quesne, J., Lynch, G., McSorley, S., Edwards, J. (2025) Does Immune Suppression in the Pre-malignant Microenvironment of Colorectal Neoplastic Lesions Associate with Development of Metachronous Polyp and Cancer Risk?

Mathews, C., Nauman, A., Johnstone, M., Stoops, R., Tham, A., Parsons, E. C., Robb, K. A., Sloan, W., Lynch, G., Edwards, J., McSorley, S. T. (2025) Retrospective cohort study: scope for improvement - barriers to post-polypectomy surveillance in the integrated technologies for improved polyp surveillance cohort. Alimentary Pharmacology and Therapeutics, (doi: 10.1111/apt.18514)

Ibrahim, I., Kouli, O., Ilangovan, S., Sneddon, M., Nalagatla, S., Marshall, C., Dutto, L., Leung, H. Y., Ahmad, I. (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14, (doi: 10.1002/cam4.70514)

Bradley, N. A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C. S.D., Guthrie, G. J.K., McMillan, D. C. (2025) The relationship between peri-operative systemic inflammation and survival in patients with abdominal aortic aneurysm. Annals of Vascular Surgery, 110, pp. 329-339. (doi: 10.1016/j.avsg.2024.08.024)

Ingham, A. R., McSorley, S. T., McMillan, D. C., Chong, D., Mackay, G. J., Wrobel, A., Kong, C. Y., Alani, A., Nicholson, G., Roxburgh, C. S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19, (doi: 10.1007/s11701-025-02261-0)

Mariappan, P. et al. (2024) Achieving benchmarks for national quality indicators reduces recurrence and progression in non-muscle-invasive bladder cancer. European Urology Oncology, 7, pp. 1327-1337. (doi: 10.1016/j.euo.2024.01.012)

Shamis, S. A.K., Quinn, J., Al-Badran, S., McKenzie, M., Hatthakarnkul, P., Lynch, G., Lian, G.-Y., Numprasit, W., Romics Jr, L., Andersen, D., Mallon, E., McMillan, D. C., Edwards, J. (2024) Elucidation of dysregulated pathways associated with hypoxia in oestrogen receptor-negative breast cancer. Cancer Medicine, 13, (doi: 10.1002/cam4.70274)

Pennel, K., Kurniawan, A., Al-Badran, S. S. F., Schubert Santana, L., Quinn, J., Nixon, C., Hatthakarnkul, P., Maka, N., Roxburgh, C., McMillan, D., Edwards, J. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14, (doi: 10.3390/biom14121629)

Mactier, K., Baxter, M., Peters, A., Fair, K., Hannington, L., Robertson, J., Wood, G., Sarwar, A., Bishr, M., Webb, R., Al-Zubaidi, M., Eastlake, L., Lankester, K., McInerney, S., Creedon, H., Stillie, A., Purshouse, K. (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14, (doi: 10.1136/bmjopen-2024-094838)

Liu, D., Young, F., Lamb, K. D., Claudio Quiros, A., Pancheva, A., Miller, C., Macdonald, C., Robertson, D. L., Yuan, K. (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)

Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, (doi: 10.1038/s41556-024-01543-3)

Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)

Rai, J., Pring, E. T., Knight, K., Tilney, H., Gudgeon, J., Gudgeon, M., Taylor, F., Gould, L. E., Wong, J., Andreani, S., Mai, D. V.C., Drami, I., Lung, P., Athanasiou, T., Roxburgh, C., Jenkins, J. T. (2024) Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery. Journal of Cachexia, Sarcopenia and Muscle, 15, pp. 1850-1857. (doi: 10.1002/jcsm.13536)

Galbraith, N. J., Quinn, J. A., Al-Badran, S. S., Pennel, K. A.F., Hillson, L. V.S., Hatthakarnkul, P., McKenzie, M., Maka, N., Loi, L., Frixou, M., Steele, C. W., Roxburgh, C. S., Horgan, P. G., McMillan, D. C., Edwards, J. (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48, (doi: 10.1016/j.tranon.2024.102064)

Bradley, N., Dosanj, K., Chan, S. Y. M., Wilson, A., Siddiqui, T., Forsythe, R., Roxburgh, C. S.D., McMillan, D. C., Guthrie, G. J.K. (2024) The relationship between CT-derived cervical muscle mass and quality, systemic inflammation, and survival in symptomatic patients undergoing carotid endarterectomy. BJS Open, 8, (doi: 10.1093/bjsopen/zrae114)

Lai, T.-J., Roxburgh, C., Boyd, K. A., Bouttell, J. (2024) Clinical effectiveness of robotic versus laparoscopic and open surgery: an overview of systematic reviews. BMJ Open, 14, (doi: 10.1136/bmjopen-2023-076750)

Churchhouse, A. M.D., Billard, C. V., Suzuki, T., Pohl, S. O.G., Donnelly, K., Nixon, C., Arends, M. J., Din, S., Kirkwood, K., Marques Junior, J., Von Kriegsheim, A., Coffelt, S. B., Myant, K. B. (2024) Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression. Oncogene, 43, pp. 3094-3107. (doi: 10.1038/s41388-024-03135-9)

McMenemy, C. M., Guo, D., Quinn, J. A., Greenhalgh, D. A. (2024) 14-3-3σ/Stratifin and p21 limit AKT-related malignant progression in skin carcinogenesis following MDM2-associated p53 loss. Molecular Carcinogenesis, 63, pp. 1768-1782. (doi: 10.1002/mc.23771)

Dannhorn, A., Kazanc, E., Flint, L., Guo, F., Carter, A., Hall, A. R., Jones, S. A., Poulogiannis, G., Barry, S. T., Sansom, O. J., Bunch, J., Takats, Z., Goodwin, R. J.A. (2024) Morphological and molecular preservation through universal preparation of fresh-frozen tissue samples for multimodal imaging workflows. Nature Protocols, 19, pp. 2685-2716. (doi: 10.1038/s41596-024-00987-z)

Elyan, B. M.P., Sullivan, M. K., Hedley, J., De La Mata, N., Webster, A. C., Venugopal, B., Jones, R. J., Lang, N. N., Mark, P. B., Lees, J. S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2, (doi: 10.1038/s44276-024-00081-7)

Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L. C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A. H.Y., Schofield, C. J., von Kriegsheim, A., Marsh, J. A., Pavet, V., Sansom, O. J., Illingworth, R. S., Patton, E. E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.114406)

Lukoszek, R., Inesta-Vaquera, F., Brett, N. J.M., Liang, S., Hepburn, L. A., Hughes, D. J., Pirillo, C., Roberts, E. W., Cowling, V. H. (2024) CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.114405)

Keith, N. et al. (2024) Emerging Ecologies of Health, Heritage, and Habitat: Looking into Living and Working in 2033. (doi: 10.17605/OSF.IO/BTNZ9)

Golder, A. M., Ferguson, M., McMillan, P., Mansouri, D., Horgan, P. G., Roxburgh, C. S., Dolan, R. D., McGovern, J., McMillan, D. (2024) CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer. Scientific Reports, 14, (doi: 10.1038/s41598-024-65871-y)

Pereira, B. A. et al. (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10, (doi: 10.1126/sciadv.adl1197)

Knight, K., Bigley, C., Pennel, K., Hay, J., Maka, N., McMillan, D., Park, J., Roxburgh, C., Edwards, J. (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10, (doi: 10.1002/2056-4538.12385)

Diaz, J. E.L., Barcessat, V., Bahamon, C., Hecht, C., Das, T. K., Cagan, R. L. (2024) Functional exploration of copy number alterations in a Drosophila model of triple negative breast cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050191)

Bradley, N. A., Walter, A., Roxburgh, C. S.D., McMillan, D. C., Guthrie, G. J.K. (2024) The relationship between Clinical Frailty Score, CT-derived body composition, systemic inflammation, and survival in patients with chronic limb-threatening ischemia. Annals of Vascular Surgery, 104, pp. 18-26. (doi: 10.1016/j.avsg.2023.06.012)

Thompson, J., McGovern, J., Roxburgh, C., Edwards, J., Dolan, R. D., McMillan, D. C. (2024) The relationship between LDH and GLIM criteria for cancer cachexia: systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 199, (doi: 10.1016/j.critrevonc.2024.104378)

Bradley, N.A., Walter, A., Roxburgh, C.S.D., McMillan, D.C., Guthrie, G.J.K. (2024) The relationship between clinical frailty score, CT-derived body composition, systemic inflammation, and survival in patients with chronic limb threatening ischaemia. Annals of Vascular Surgery, 104, pp. 18-26. (doi: 10.1016/j.avsg.2023.06.012)

McKenzie, M., Lian, G.-Y., Pennel, K. A.F., Quinn, J. A., Jamieson, N. B., Edwards, J. (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10, (doi: 10.1016/j.heliyon.2024.e32904)

Shiu, K.-K., Jiang, Y., Saunders, M., Seligmann, J. F., Iveson, T., Wilson, R. H., Graham, J. S., Khan, K. H., Militello, A.-M., Irvine, S., Adedoyin, T., Begum, R., Bhat, R., Wilson, W., Plumb, A., Obichere, A., Rodriguez-Justo, M., Jansen, M. (2024) NEOPRISM-CRC: Neoadjuvant pembrolizumab stratified to tumour mutation burden for high risk stage 2 or stage 3 deficient-MMR/MSI-high colorectal cancer. (doi: 10.1200/jco.2024.42.17_suppl.lba3504)

Kumar, S., Basto, A. P., Ribeiro, F., Almeida, S. C.P., Campos, P., Peres, C., Pulvirenti, N., Al-Khalidi, S., Kilbey, A., Tosello, J., Piaggio, E., Russo, M., Gama-Carvalho, M., Coffelt, S. B., Roberts, E. W., Geginat, J., Florindo, H. F., Graca, L. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, (doi: 10.1038/s41421-024-00681-0)

Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, (doi: 10.1038/s41588-024-01809-4)

Peters, A.L., Hall, P.S., Jordan, L.B., Soh, F.Y., Hannington, L., Makaranka, S., Urquhart, G., Vallet, M., Cartwright, D., Marashi, H., Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75, (doi: 10.1016/j.breast.2024.103728)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1)

Sumaria, N., Fiala, G. J., Inácio, D., Curado-Avelar, M., Cachucho, A., Pinheiro, R., Wiesheu, R., Kimura, S., Courtois, L., Blankenhaus, B., Darrigues, J., Suske, T., Almeida, A. R. M., Minguet, S., Asnafi, V., Lhermitte, L., Mullighan, C. G., Coffelt, S. B., Moriggl, R., Barata, J. T., Pennington, D. J., Silva-Santos, B. (2024) Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms. Nature Immunology, (doi: 10.1038/s41590-024-01855-4)

Rescigno, P. et al. (2024) Capivasertib in combination with enzalutamide for metastatic castration resistant prostate cancer after docetaxel and abiraterone: Results from the randomized phase II RE-AKT trial. European Journal of Cancer, 205, (doi: 10.1016/j.ejca.2024.114103)

Bradley, N. A., Roxburgh, C. S.D., McMillan, D. C., Guthrie, G. J.K. (2024) A systematic review of the neutrophil to lymphocyte and platelet to lymphocyte ratios in patients with lower extremity arterial disease. European Journal of Vascular Medicine, 53, pp. 155-171. (doi: 10.1024/0301-1526/a001117)

Hatthakarnkul, P., Pennel, K., Alexander, P., Van Wyk, H., Roseweir, A., Inthagard, J., Hay, J., Andersen, D., Maka, N., Park, J., Roxburgh, C., Thuwajit, C., McMillan, D., Edwards, J. (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10, (doi: 10.1002/2056-4538.12374)

Thapa, A., Cowell, A., Peters, A., Noble, D. J., James, A., Lamb, C., Grose, D., Vohra, S., Schipani, S., Mactier, K., Mackenzie, J., Srinivasan, D., Laws, K., Moleron, R., Niblock, P., Soh, F.-Y., Paterson, C., Wilson, C. (2024) The UK Divide: Does having a Pembrolizumab-Chemotherapy option in head and neck cancer matter? Real-world experience of first-line palliative pembrolizumab monotherapy and pembrolizumab-chemotherapy combination in Scotland. Clinical Oncology, 36, pp. 287-299. (doi: 10.1016/j.clon.2024.02.004)

Keith, N., Ross, K., Campbell, H., McCrum, P., Uribe, V., Rowan, F. (2024) Designing Future Experiences: The value of exhibition spaces as creative environments for collaborative, multidisciplinary research, exhibitions, and audiences. (doi: 10.17605/OSF.IO/N7MD9)

Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J. S., Petrie, M. C., Lang, N. N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)

Pennel, K., Dutton, L., Melissourgou-Syka, L., Roxburgh, C., Birch, J., Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, (doi: 10.1017/erm.2024.15)

Malviya, G., Lannagan, T. R.M., Johnson, E., Mackintosh, A., Bielik, R., Peters, A., Soloviev, D., Brown, G., Jackstadt, R., Nixon, C., Gilroy, K., Campbell, A., Sansom, O. J., Lewis, D. Y. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30, pp. 1518-1529. (doi: 10.1158/1078-0432.ccr-23-1063)

Brown, L. R., Thomson, G. G., Gardner, E., Chien, S., McGovern, J., Dolan, R. D., McSorley, S. T., Forshaw, M. J., McMillan, D. C., Wigmore, S. J., Crumley, A., Skipworth, R. J.E. (2024) Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study. British Journal of Surgery, 111, (doi: 10.1093/bjs/znae098)

Lupo, F., Coffelt, S. B. (2024) Stressed out neutrophils drive metastasis. Immunity, 57, pp. 840-842. (doi: 10.1016/j.immuni.2024.03.013)

Bradley, N., Dosanj, K., Ming Chan, S. Y., Wilson, A., Siddiqui, T., Forsythe, R., Roxburgh, C. S.D., McMillan, D. C., Guthrie, G. J.K. (2024) The Relationship Between CT-derived Cervical Muscle Mass and Quality, Systemic Inflammation, and Survival in Symptomatic Patients Undergoing Carotid Endarterectomy. (doi: 10.1016/j.jvs.2024.01.080)

Bradley, N. A., McGovern, J., Dolan, R. D., Golder, A. M., Roxburgh, C. S.D., Guthrie, G. J.K., McMillan, D. C. (2024) CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study. PLoS ONE, 19, (doi: 10.1371/journal.pone.0300038)

Nair, R., Lannagan, T. R.M., Jackstadt, R., Andrusaite, A., Cole, J., Boyne, C., Nibbs, R. J.B., Sansom, O. J., Milling, S. (2024) Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance. OncoImmunology, 13, (doi: 10.1080/2162402X.2024.2330194)

Ingham,, A. R., Kong, C. Y., Wong, T.-N., McSorley, S. T., McMillan, D. C., Nicholson, G. A., Alani, A., Mansouri, D., Chong, D., Mackay, G. J., Roxburgh, C. S.D. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy, (doi: 10.1007/s00464-024-10749-3)

Domingo, E. et al. (2024) Prognostic and predictive value of Immunoscore in stage III colorectal cancer: pooled analysis of 2,608 cases from the SCOT and IDEA-HORG studies. Journal of Clinical Oncology, (doi: 10.1200/JCO.23.01648)

Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J., Sansom, O. J., O'Neill, E., Jones, K., Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050463)

(2024) Special Issue – Cell and Tissue Polarity. Journal of Cell Science, 137,

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, (doi: 10.1186/s13046-024-02958-4)

Critchlow, S., Bullement, A., Crabb, S., Jones, R., Christoforou, K., Amin, A., Xiao, Y., Kapetanakis, V., Benedict, Á., Chang, J., Kearney, M., Eccleston, A. (2024) Cost–effectiveness analysis for avelumab first-line maintenance treatment of advanced urothelial carcinoma in Scotland. Future Oncology, 20, pp. 459-470. (doi: 10.2217/fon-2023-0372)

Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56, pp. 458-472. (doi: 10.1038/s41588-024-01654-5)

Birtle, A. J., Jones, R., Chester, J., Lewis, R., Biscombe, K., Johnson, M., Blacker, A., Bryan, R., Catto, J. W.F., Choudhury, A., Das, P., Jagdev, S., Powles, T., Wagstaff, J., Cheung, K. C., Cafferty, F., Hall, E. (2024) Improved disease-free survival with adjuvant chemotherapy after nephroureterectomy for upper tract urothelial cancer: Final results of the POUT trial. Journal of Clinical Oncology, (doi: 10.1200/jco.23.01659)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, (doi: 10.1038/s41467-024-45471-0)

Fetit, R., McLaren, A. S., White, M., Mills, M. L., Falconer, J., Cortes-Lavaud, X., Gilroy, K., Lannagan, T. R.M., Ridgway, R. A., Nixon, C., Naiker, V., Njunge, R., Clarke, C., Whyte, D., Kirschner, K., Jackstadt, R., Norman, J., Carlin, L. M., Campbell, A. D., Sansom, O. J., Steele, C. W. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4, pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319)

Frei, A. L. et al. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25, pp. 198-211. (doi: 10.1016/S1470-2045(23)00560-0)

Fizazi, K., Azad, A. A., Matsubara, N., Carles, J., Fay, A. P., De Giorgi, U., Joung, J. Y., Fong, P. C.C., Voog, E., Jones, R. J., Shore, N. D., Dunshee, C., Zschäbitz, S., Oldenburg, J., Ye, D., Lin, X., Healy, C. G., Di Santo, N., Laird, A. D., Zohren, F., Agarwal, N. (2024) Publisher Correction: First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial. Nature Medicine, 30, (doi: 10.1038/s41591-024-02835-9)

Hillson, L. V. S., McCulloch, A. K., Edwards, J., Dunne, P. D., O'Cathail, S. M., Roxburgh, C. S. (2024) Radiation-induced changes in gene expression in rectal cancer specimens. Clinical and Translational Oncology, (doi: 10.1007/s12094-023-03361-9)

Welisch, G., Keith, N., Jones, R., Hanna, C. (2024) Creative approaches to reimagining patient and public involvement (PPI) in cancer research. (doi: 10.17605/OSF.IO/243XN)

Cong, B., Cagan, R. L. (2024) Cell competition and cancer from Drosophila to mammals. Oncogenesis, 13, (doi: 10.1038/s41389-023-00505-y)

Shamis, S. A. K., Savioli, F., Ammar, A., Al-Badran, S. S.F., Hatthakarnkul, P., Leslie, H., Mallon, E., Jamieson, N. B., McMillan, D. C., Edwards, J. (2024) Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay. Histology and Histopathology: Cellular and Molecular Biology, 39, pp. 177-200. (doi: 10.14670/HH-18-655)

Brouwer, N.P.M., Khan, A., Bokhorst, J.M., Ayatollahi, F., Hay, J., Ciompi, F., Simmer, F., Hugen, N., de Wilt, J.H.W., Berger, M.D., Lugli, A., Zlobec, I., Edwards, J., Nagtegaal, I.D. (2024) The complexity of shapes: how the circularity of tumor nodules impacts prognosis in colorectal cancer. Modern Pathology, 37, (doi: 10.1016/j.modpat.2023.100376)

Johnstone, M. S., McSorley, S. T., McMillan, D. C., Horgan, P. G., Mansouri, D. (2024) The relationship between systemic inflammatory response, screen detection and outcome in colorectal cancer. Colorectal Disease, 26, pp. 81-94. (doi: 10.1111/codi.16824)

Keith, N., Donaldson, M. (2024) Professional and Technical Staff supporting Open Research: Case Study 4. Research-enabling staff and Open Research.

Knop, K., Gomez-Moreira, C., Galloway, A., Ditsova, D., Cowling, V. H. (2024) RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression. Discovery Immunology, 3, (doi: 10.1093/discim/kyad021)

Bryant, D. M. (2023) We are the system. Journal of Cell Science, 136, (doi: 10.1242/jcs.261864)

Skeldon, K. et al. (2023) Research Firsts Exhibition. (doi: 10.17605/OSF.IO/ZQC5P)

Fizazi, K., Azad, A. A., Matsubara, N., Carles, J., Fay, A. P., De Giorgi, U., Joung, J. Y., Fong, P. C. C., Voog, E., Jones, R. J., Shore, N. D., Dunshee, C., Zschäbitz, S., Oldenburg, J., Ye, D., Lin, X., Healy, C. G., Di Santo, N., Laird, A. D., Zohren, F., Agarwal, N. (2023) First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: The phase 3 TALAPRO-2 trial. Nature Medicine, 30, pp. 257-264. (doi: 10.1038/s41591-023-02704-x)

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133, (doi: 10.1172/JCI168277)

Neilson, L. J., Cartwright, D., Risteli, M., Jokinen, E. M., McGarry, L., Sandvik, T., Nikolatou, K., Hodge, K., Atkinson, S., Vias, M., Kay, E. J., Brenton, J. D., Carlin, L. M., Bryant, D. M., Salo, T., Zanivan, S. (2023) Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment. Matrix Biology Plus, 19-20, (doi: 10.1016/j.mbplus.2023.100136)

Malik, N., Hay, J., Almuhanna, H. N.B., Dunn, K. M., Lees, J., Cassels, J., Li, J., Nakagawa, R., Sansom, O. J., Michie, A. M. (2023) mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia. Leukemia, 37, pp. 2414-2425. (doi: 10.1038/s41375-023-02043-3)

Lewis, D. Y. (2023) Multiplexing autoradiography. Humana

McLaren, A. S., Spoor, J. A., Cartwright, D., Naylor, G., Barclay, S., Priest, M., Puttagunta, S., Armstrong, K., Ballantyne, S., Stanley, A., Evans, T. R. J., West of Scotland HCC MDT, (2023) Impact of the COVID-19 pandemic on patients with hepatocellular carcinoma in the west of Scotland: a cohort study. BMJ Open Gastroenterology, 10, (doi: 10.1136/bmjgast-2023-001231)

Zarou, M. M., Dawson, A., Prasad, B., Bittencourt-Silvestre, J., Zerbst, D., Rodriguez Blanco, G., Scott, M., Dunn, K., Krishnan, V., Copland, M., Vetrie, D., Bhatia, R., Coffelt, S., Ong, S. T., Wheadon, H., Zanivan, S., Kirschner, K., Helgason, G. V. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. (doi: 10.1182/blood-2023-181630)

Taggart, R., Dutto, L., Leung, H. Y., Salji, M., Ahmad, I. (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP) Cancer Medicine, 12, pp. 20830-20837. (doi: 10.1002/cam4.6651)

Frei, A. L. et al. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9, pp. 449-463. (doi: 10.1002/cjp2.342)

Conroy, S., Catto, J. W.F., Bex, A., Brown, J. E., Cartledge, J., Fielding, A., Jones, R. J., Khoo, V., Nicol, D., Stewart, G. D., Sullivan, M., Tran, M. G.B., Woodward, R., Cumberbatch, M. G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132, pp. 541-553. (doi: 10.1111/bju.16128)

Galbraith, N. J., McCollum, C., Di Mascio, L., Lowrie, J., Hinckley, M., Lo, S., Watson, S., Telfer, J. R.C., Roxburgh, C. S., Horgan, P. S., Chong, P. S., Quinn, M., Steele, C. W. (2023) Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study. International Journal of Surgery, 109, pp. 3375-3382. (doi: 10.1097/JS9.0000000000000617)

Holt, A. K., Najumudeen, A. K., Collard, T. J., Li, H., Millett, L. M., Hoskin, A. J., Legge, D. N., Mortensson, E. M.H., Flanagan, D. J., Jones, N., Kollareddy, M., Timms, P., Hitchings, M. D., Cronin, J., Sansom, O. J., Williams, A. C., Vincent, E. E. (2023) Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition. Cancer and Metabolism, 11, (doi: 10.1186/s40170-023-00318-y)

Johnstone, M. S., McSorley, S. T., McMahon, A. J. (2023) Management of malignant T1 colorectal cancer polyps: results from a 10-year prospective observational study. Colorectal Disease, 25, pp. 1960-1972. (doi: 10.1111/codi.16716)

Parsons, E. C., Baillie, G. S., Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480, pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Bradley, N.A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C.S.D., McMillan, D.C., Guthrie, G.J.K. (2023) The relationship between CT-derived body composition, systemic inflammation, and survival in patients with abdominal aortic aneurysm. Journal of Vascular Surgery, 78, pp. 937-944.e4. (doi: 10.1016/j.jvs.2023.06.012)

Dzien, P., Mackintosh, A., Malviya, G., Johnson, E., Soloviev, D., Brown, G., Huerta Uribe, A., Nixon, C., Lyons, S. K., Maddocks, O., Blyth, K., Lewis, D. (2023) Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo. Cancer and Metabolism, 11, (doi: 10.1186/s40170-023-00314-2)

Nikolatou, K., Sandilands, E., Román-Fernández, A., Cumming, E. M., Freckmann, E., Lilla, S., Buetow, L., McGarry, L., Neilson, M., Shaw, R., Strachan, D., Miller, C., Huang, D. T., Mcneish, I. A., Norman, J. C., Zanivan, S., Bryant, D. M. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, (doi: 10.15252/embj.2023113987)

McMahon, R. K., O'Cathail, S. M., Nair, H., Steele, C. W., Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G., Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25, pp. 1783-1794. (doi: 10.1111/codi.16667)

Quintana, J. F., Sinton, M. C., Chandrasegaran, P., Lestari, A. N., Heslop, R., Cheaib, B., Ogunsola, J., Ngoyi, D. M., Swar, N.-R. K., Cooper, A., Mabbott, N. A., Coffelt, S. B., MacLeod, A. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, (doi: 10.1038/s41467-023-40962-y)

Bailey, P., Ridgway, R. L., Cammareri, P., Treanor-Taylor, M., Bailey, U.-M., Schoenherr, C., Bone, M., Schreyer, D., Purdie, K., Thomson, J., Rickaby, W., Jackstadt, R., Campbell, A. D., Dimonitsas, E., Stratigos, A. J., Arron, S. T., Wang, J., Blyth, K., Proby, C. M., Harwood, C. A., Sansom, O. J., Leigh, I. M., Inman, G. J. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, (doi: 10.1038/s41467-023-40822-9)

Nikolatou, K., Bryant, D. M., Sandilands, E. (2023) The ARF GTPase regulatory network in collective invasion and metastasis. Biochemical Society Transactions, 51, pp. 1559-1569. (doi: 10.1042/BST20221355)

Suzuki, T. et al. (2023) β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer Immunology Research, 11, pp. 1137-1155. (doi: 10.1158/2326-6066.CIR-22-0644)

Bradley, N. A., Walter, A., Dolan, R., Wilson, A., Siddiqui, T., Roxburgh, C. S.D., McMillan, D. C., Guthrie, G. J.K. (2023) Evaluation of the prognostic value of computed tomography-derived body composition in patients undergoing endovascular aneurysm repair. Journal of Cachexia, Sarcopenia and Muscle, 14, pp. 1836-1847. (doi: 10.1002/jcsm.13262)

Staedtke, V., Topilko, P., Le, L. Q., Grimes, K., Largaespada, D. A., Cagan, R. L., Steensma, M. R., Stemmer-Rachamimov, A., Blakeley, J. O., Rhodes, S. D., Ly, I., Romo, C. G., Lee, S. Y., Serra, E. (2023) Existing and developing preclinical models for neurofibromatosis type 1−related cutaneous neurofibromas. Journal of Investigative Dermatology, 143, pp. 1378-1387. (doi: 10.1016/j.jid.2023.01.042)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5, pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0)

Bradley, N.A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C.S.D., McMillan, D.C., Guthrie, G.J.K. (2023) The prognostic value of pre-operative systemic inflammation-based scoring in patients undergoing endovascular repair of AAA. Journal of Vascular Surgery, 78, pp. 362-369.e2. (doi: 10.1016/j.jvs.2023.04.018)

Zaweia, R., Alyamani, A., McMenemy, C., Quinn, J., Greenhalgh, D. (2023) Inducible E-cadherin Ablation Drives Malignant Progression in HK1.ras.fos.PTENflx/flx Carcinogenesis and Induces Conversion of HK1.fos.PTENflx/flx Keratoacanthoma. (doi: 10.1093/bjd/ljad174.044)

Murphy, M., McCaughan, E., Thompson, G., Carson, M. A., Hanna, J. R., Donovan, M., Wilson, R. H., Fitzsimons, D. (2023) Trusting relationships between patients with non-curative cancer and healthcare professionals create ethical obstacles for informed consent in clinical trials: a grounded theory study. BMC Palliative Care, 22, (doi: 10.1186/s12904-023-01204-6)

Elyan, B. M.P., Rankin, S., Jones, R., Lang, N. N., Mark, P. B., Lees, J. S. (2023) Kidney disease patient representation in trials of combination therapy with VEGF-signaling pathway inhibitors and immune checkpoint inhibitors: a systematic review. Kidney Medicine, 5, (doi: 10.1016/j.xkme.2023.100672)

Farahmand, P., Gyuraszova, K., Rooney, C., Raffo-Iraolagoitia, X. L., Jayasekera, G., Hedley, A., Johnson, E., Chernova, T., Malviya, G., Hall, H., Monteverde, T., Blyth, K., Duffin, R., Carlin, L. M., Lewis, D., le Quesne, J., MacFarlane, M., Murphy, D. J. (2023) Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Frontiers in Toxicology, 5, (doi: 10.3389/ftox.2023.1200650)

Hatthakarnkul, P., Ammar, A., Pennel, K. A.F., Officer-Jones, L., Cusumano, S., Quinn, J. A., Matly, A. A. M., Alexander, P. G., Hay, J., Andersen, D., Lynch, G., Van Wyk, H. C., Maka, N., McMillan, D. C., Le Quesne, J., Thuwajit, C., Edwards, J. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14, pp. 1837-1847. (doi: 10.7150/jca.83910)

Tibbo, A. J., Hartley, A., Vasan, R., Shaw, R., Galbraith, L., Mui, E., Leung, H. Y., Ahmad, I. (2023) MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer. British Journal of Cancer, 128, pp. 1991-1999. (doi: 10.1038/s41416-023-02237-7)

Catto, J. W.F., Mandrik, O., Quayle, L. A., Hussain, S. A., McGrath, J., Cresswell, J., Birtle, A. J., Jones, R. J., Mariappan, P., Makaroff, L. E., Knight, A., Mostafid, H., Chilcott, J., Sasieni, P., Cumberbatch, M. (2023) Diagnosis, treatment and survival from bladder, upper urinary tract, and urethral cancers: real-world findings from NHS England between 2013 and 2019. BJU International, 131, pp. 734-744. (doi: 10.1111/bju.15970)

Pennel, K., Morrow, E., Hatthakarnkul, P., Leslie, H., Mallon, E., Andersen, D., Jamieson, N., McMillan, D., Roseweir, A., Edwards, J. (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12, pp. 13225-13240. (doi: 10.1002/cam4.6014)

Brown, G., Soloviev, D., Lewis, D. Y. (2023) Radiosynthesis and analysis of (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid. Molecular Imaging and Biology, 25, pp. 586-595. (doi: 10.1007/s11307-022-01793-3)

Mar, N., Zakharia, Y., Falcon, A., Morales-Barrera, R., Mellado, B., Duran, I., Oh, D.-Y., Williamson, S. K., Gajate, P., Arkenau, H.-T., Jones, R. J., Teo, M. Y., Turan, T., McLaughlin, R. T., Peltier, H. M., Chong, E., Atluri, H., Dean, J. P., Castellano, D. (2023) Results from a phase 1b/2 study of ibrutinib combination therapy in advanced urothelial carcinoma. Cancers, 15, (doi: 10.3390/cancers15112978)

Johnstone, M. S., Stoops, R., Lynch, G., Hay, J., Jawny, J., Sloan, W., Edwards, J., McSorley, S. T. (2023) Risk stratification for the detection of metachronous polyps after bowel screening polypectomy: clinical outcomes from the Integrated Technologies for Improved Polyp Surveillance (INCISE) study cohort. BJS Open, 7, (doi: 10.1093/bjsopen/zrad034)

Liang, S., Almohammed, R., Cowling, V. H. (2023) The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation. Biochemical Society Transactions, 51, pp. 1131-1141. (doi: 10.1042/BST20221154)

Day, E. K., Galbraith, N. J., Ward, H. J.T., Roxburgh, C. S. (2023) Volume-outcome relationship in intra-abdominal robotic-assisted surgery: a systematic review. Journal of Robotic Surgery, 17, pp. 811-826. (doi: 10.1007/s11701-022-01461-2)

Attard, G. et al. (2023) Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol. Lancet Oncology, 24, pp. 443-456. (doi: 10.1016/S1470-2045(23)00148-1)

May, S., Muller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Voorde, J. V., Officer-Jones, L., Ballantyne, F., Powley, I. R., Drake, T. M., Kiourtis, C., Keith, A., Rocha, A. S., Tardito, S., Sumpton, D., Le Quesne, J., Bushell, M., Sansom, O. J., Bird, T. G. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78, pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009)

Gillessen, S. et al. (2023) Management of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022. European Journal of Cancer, 185, pp. 178-215. (doi: 10.1016/j.ejca.2023.02.018)

Lees, J. S., Elyan, B. M.P., Hermann, S. M., Lang, N. N., Jones, R. J., Mark, P. B. (2023) The ‘other’ big complication: how chronic kidney disease impacts on cancer risks and outcomes. Nephrology Dialysis Transplantation, 38, pp. 1071-1079. (doi: 10.1093/ndt/gfac011)

Conway, J. R. W. et al. (2023) Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse. Science Advances, 9, (doi: 10.1126/sciadv.adf9063)

Wood, C. S., Pennel, K. A.F., Leslie, H., Legrini, A., Cameron, A. J., Melissourgou-Syka, L., Quinn, J. A., van Wyk, H. C., Hay, J., Roseweir, A. K., Nixon, C., Roxburgh, C. S.D., McMillan, D. C., Biankin, A. V., Sansom, O. J., Horgan, P. G., Edwards, J., Steele, C. W., Jamieson, N. B. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83, pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794)

Shamis, S. A.K., Edwards, J., McMillan, D. C. (2023) The relationship between carbonic anhydrase IX (CAIX) and patient survival in breast cancer: systematic review and meta-analysis. Diagnostic Pathology, 18, (doi: 10.1186/s13000-023-01325-9)

Hartley, A., Ahmad, I. (2023) The role of PPARγ in prostate cancer development and progression. British Journal of Cancer, 128, pp. 940-945. (doi: 10.1038/s41416-022-02096-8)

Sandilands, E., Freckmann, E. C., Cumming, E. M., Román-Fernández, A., McGarry, L., Anand, J., Galbraith, L., Mason, S., Patel, R., Nixon, C., Cartwright, J., Leung, H. Y., Blyth, K., Bryant, D. M. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222, (doi: 10.1083/jcb.202206115)

Alizzi, Z., Roxburgh, P., Cartwright, D., McLaren, A., Park, S., Jones, R., Greening, S., Hudson, E., Green, C., Gray, S., Khalique, S., Karteris, E., Hall, M. (2023) Description of a retrospective cohort of epithelial ovarian cancer patients with brain metastases: evaluation of the role of PARP inhibitors in this setting. Journal of Clinical Medicine, 12, (doi: 10.3390/jcm12072497)

Barry, S. T., Gabrilovich, D. I., Sansom, O. J., Campbell, A. D., Morton, J. P. (2023) Therapeutic targeting of tumour myeloid cells. Nature Reviews Cancer, 23, pp. 216-237. (doi: 10.1038/s41568-022-00546-2)

Amirkhah, R., Gilroy, K., Malla, S. B., Lannagan, T. R.M., Byrne, R. M., Fisher, N. C., Corry, S. M., Mohamed, N.-E., Naderi-Meshkin, H., Mills, M. L., Campbell, A. D., Ridgway, R. A., Ahmaderaghi, B., Murray, R., Llergo, A. B., Sanz-Pamplona, R., Villanueva, A., Batlle, E., Salazar, R., Lawler, M., Sansom, O. J., Dunne, P. D. (2023) MmCMS: mouse models' consensus molecular subtypes of colorectal cancer. British Journal of Cancer, 128, pp. 1333-1343. (doi: 10.1038/s41416-023-02157-6)

Numprasit, W., Yangngam, S., Prasopsiri, J., Quinn, J. A., Edwards, J., Thuwajit, C. (2023) Carbonic anhydrase IX-related tumoral hypoxia predicts worse prognosis in breast cancer: a systematic review and meta-analysis. Frontiers in Medicine, 10, (doi: 10.3389/fmed.2023.1087270)

Coffelt, S. B., Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4, pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Bennett, S. S., Leung, H. Y., Ahmad, I. (2023) A cohort analysis of patients receiving neoadjuvant androgen deprivation therapy prior to robot-assisted laparoscopic prostatectomy during the Covid-19 pandemic. Journal of Clinical Urology, 16, pp. 13-139. (doi: 10.1177/20514158211022216)

Villar, V. H., Allega, M. F., Deshmukh, R., Ackermann, T., Nakasone, M. A., Vande Voorde, J., Drake, T. M., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E. H., Vereecke, L., Jans, M., Blancke, G., Murphy, D. J., Huang, D. T., Lewis, D. Y., Bird, T. G., Sansom, O. J., Blyth, K., Sumpton, D., Tardito, S. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19, pp. 292-300. (doi: 10.1038/s41589-022-01154-9)

Gillessen, S. et al. (2023) Management of patients with advanced prostate cancer. Part I: intermediate-/high-risk and locally advanced disease, biochemical relapse, and side effects of hormonal treatment: report of the advanced prostate cancer consensus conference 2022. European Urology, 83, pp. 267-293. (doi: 10.1016/j.eururo.2022.11.002)

Chen, F., Gurler, S. B., Novo, D., Selli, C., Alferez, D. G., Eroglu, S., Pavlou, K., Zhang, J., Sims, A. H., Humphreys, N. E., Adamson, A., Campbell, A., Sansom, O. J., Tournier, C., Clarke, R. B., Brennan, K., Streuli, C. H., Ucar, A. (2023) RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene, 42, pp. 679-692. (doi: 10.1038/s41388-022-02574-6)

Alexander, P.G., van Wyk, H.C., Pennel, K.A.F., Hay, J., McMillan, D.C., Horgan, P.G., Roxburgh, C.S.D., Edwards, J., Park, J.H. (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128, pp. 556-567. (doi: 10.1038/s41416-022-02069-x)

Rushworth, L. K., Loveridge, C., Salji, M., MacLeod, M., Mui, E., Sumpton, D., Neilson, M., Hedley, A., Alexander, L., McCartney, E., Patel, R., Wallace, J., Delles, C., Jones, R., Leung, H. Y. (2023) Phase II proof of concept study of atorvastatin in castration resistant prostate cancer. BJU International, 131, pp. 236-243. (doi: 10.1111/bju.15851)

Keith, N. et al. (2023) Regenerative Futures: From Global to Local Development in 2032. (doi: 10.36399/gla.pubs.295862)

Gravestock, P., Clark, E., Morton, M., Sharma, S., Fisher, H., Walker, J., Wood, R., Hancock, H., Waugh, N., Cooper, A., Maier, R., Marshall, J., Chandler, R., Bahl, A., Crabb, S., Jain, S., Pedley, I., Jones, R., Staffurth, J., Heer, R. (2023) Using the AR-V7 biomarker to determine treatment in metastatic castrate resistant prostate cancer, a feasibility randomised control trial, conclusions from the VARIANT trial. NIHR Open Research, 2, (doi: 10.3310/nihropenres.13284.2)

Crabb, S. J., Hussain, S., Soulis, E., Hinsley, S., Dempsey, L., Trevethan, A., Song, Y., Barber, J., Frew, J., Gale, J., Faust, G., Brock, S., McGovern, U., Parikh, O., Enting, D., Sundar, S., Ratnayake, G., Lees, K., Birtle, A. J., Powles, T., Jones, R. J. (2023) A randomized, double-blind, biomarker-selected, phase ii clinical trial of maintenance poly adp-ribose polymerase inhibition with rucaparib following chemotherapy for metastatic urothelial carcinoma. Journal of Clinical Oncology, 41, pp. 54-64. (doi: 10.1200/JCO.22.00405)

Tandon, V., Moreno, R., Allmeroth, K., Quinn, J., Wiley, S. E., Nicely, L. G., Denzel, M. S., Edwards, J., de la Vega, L., Banerjee, S. (2023) Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Bioscience Reports, 34, (doi: 10.1042/BSR20222102)

McGovern, J., Delaney, J., Forshaw, M. J., McCabe, G., Crumley, A. B., McIntosh, D., Laird, B. J., Horgan, P. G., McMillan, D. C., McSorley, S. T., Dolan, R. D. (2023) The relationship between computed tomography-derived sarcopenia, cardiopulmonary exercise testing performance, systemic inflammation, and survival in good performance status patients with oesophago-gastric cancer undergoing neoadjuvant treatment. JCSM Clinical Reports, 8, pp. 3-11. (doi: 10.1002/crt2.57)

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9, (doi: 10.1126/sciadv.abq1858)

Soloviev, D., Dzien, P., Mackintosh, A., Malviya, G., Brown, G., Lewis, D. (2022) High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET. EJNMMI Radiopharmacy and Chemistry, 7, (doi: 10.1186/s41181-022-00185-w)

Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, (doi: 10.1038/s41467-022-35134-3)

Corry, S. M. et al. (2022) Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71, pp. 2502-2517. (doi: 10.1136/gutjnl-2021-326183)

Knight, J. R.P., Proud, C. G., Mallucci, G., von der Haar, T., Smales, C. M., Willis, A. E., Sansom, O. J. (2022) Eukaryotic elongation factor 2 kinase activity is required for the phenotypes of the Rpl24Bst mouse. Journal of Investigative Dermatology, 142, pp. 3346-3348.e1. (doi: 10.1016/j.jid.2022.06.019)

van Wagensveld, L., van Baal, J. O. A. M., Timmermans, M., Gaillard, D., Borghuis, L., Coffelt, S. B., Rosenberg, E. H., Lok, C. A. R., Nijman, H. W., Kooreman, L. F. S., Sanders, J., de Bruijn, M., Wessels, L. F. A., van der Wiel, R., Rausch, C., Broeks, A., Kruitwagen, R. F. P. M., van der Aa, M. A., Sonke, G. S., Schouten, P. C., Van de Vijver, K. K., Horlings, H. M. (2022) Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer. Cancers, 14, (doi: 10.3390/cancers14235965)

Johnstone, M. S., MacLeod, C., Digby, J., Al-Azzawi, Y., Pang, G., Watson, A. J.M., Strachan, J., Mowat, C., McSorley, S. T. (2022) Prevalence of repeat faecal immunochemical testing in symptomatic patients attending primary care. Colorectal Disease, 24, pp. 1498-1504. (doi: 10.1111/codi.16240)

Ali, A., Jamieson, N. B., Khan, I. Q., Chang, D., Giovannetti, E., Funel, N., Frampton, A.E., Morton, J., Sansom, O., Evans, T.R.J., Duthie, F., McKay, C. J., Samra, J.S., Gill, A. J., Biankin, A., Oien, K. A. (2022) Prognostic implications of microRNA-21 overexpression in pancreatic ductal adenocarcinoma: an international multicenter study of 686 patients. American Journal of Cancer Research, 12, pp. 5668-5683.

Savioli, F., Morrow, E. S., Dolan, R. D., Romics, L., Lannigan, A., Edwards, J., McMillan, D. C. (2022) Prognostic role of preoperative circulating systemic inflammatory response markers in primary breast cancer: meta-analysis. British Journal of Surgery, 109, pp. 1206-1215. (doi: 10.1093/bjs/znac319)

Ramadan, R., Wouters, V. M., van Neerven, S. M., de Groot, N. E., Martins, G. T., Muncan, V., Franklin, O. D., Battle, M., Carlson, K. S., Leach, J., Sansom, O. J., Boulard, O., Chamaillard, M., Vermeulen, L., Medema, J. P., Huels, D. J. (2022) The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biology Open, 11, (doi: 10.1242/bio.059544)

Patel, M., McAllister, M., Nagaraju, R., Al Badran, S. S. F., Edwards, J., McBain, A. J., Barriuso, J., Aziz, O. (2022) The intestinal microbiota in colorectal cancer metastasis - Passive observer or key player? Critical Reviews in Oncology/Hematology, 180, (doi: 10.1016/j.critrevonc.2022.103856)

Golder, A. M., Sin, L. K. E., Alani, F., Dolan, R., Mansouri, D., Horgan, P. G., McMillan, D. C., Roxburgh, C. S. (2022) The relationship between the mode of presentation, CT-derived body composition, systemic inflammatory grade and survival in colon cancer. Journal of Cachexia, Sarcopenia and Muscle, 13, pp. 2863-2874. (doi: 10.1002/jcsm.13097)

Keith, N., Welisch, G., Ross, K., Smykowski, A. (2022) The Curious Researchers.

Evans, J., Keith, N., Paul, J. (2022) An analysis of Relative Telomere Length (RTL) during peri-operative chemotherapy in patients with operable gastric or gastro-oesophageal junction adenocarcinoma. (doi: 10.17504/protocols.io.ca5csg2w)

Pennel, K. A. F., Quinn, J. A., Nixon, C., Inthagard, J., van Wyk, H. C., Chang, D., Rebus, S., GPOL Group, , Hay, J., Maka, N. N., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C., Park, J. H., Roseweir, A. K., Steele, C. W., Edwards, J. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8, pp. 509-520. (doi: 10.1002/cjp2.290)

Crabb, S. J., Griffiths, G., Dunkley, D., Downs, N., Ellis, M., Radford, M., Light, M., Northey, J., Whitehead, A., Wilding, S., Birtle, A. J., Khoo, V., Jones, R. J. (2022) Overall survival update for patients with metastatic castration-resistant prostate cancer treated with capivasertib and docetaxel in the phase 2 ProCAID clinical trial. European Urology, 82, pp. 512-515. (doi: 10.1016/j.eururo.2022.05.019)

Hedayioglu, F., Mead, E. J., O‘Connor, P. B.F., Skiotys, M., Sansom, O. J., Mallucci, G. R., Willis, A. E., Baranov, P. V., Smales, C. M., von der Haar, T. (2022) Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles. Nucleic Acids Research, 50, (doi: 10.1093/nar/gkac705)

Edwards, S. C., Hedley, A., Hoevenaar, W. H.M., Wiesheu, R., Glauner, T., Kilbey, A., Shaw, R., Boufea, K., Batada, N., Hatano, S., Yoshikai, Y., Blyth, K., Miller, C., Kirschner, K., Coffelt, S. B. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220, (doi: 10.1084/jem.20211431)

Stewart, G. D. et al. (2022) A phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA) British Journal of Cancer, 127, pp. 1051-1060. (doi: 10.1038/s41416-022-01883-7)

Bradley, N.A., Roxburgh, C.S.D., McMillan, D.C., Guthrie, G.J.K. (2022) The relationship between pre-operative psoas and skeletal muscle parameters and survival following endovascular aneurysm repair: a systematic review and meta-analysis. Scientific Reports, 12, (doi: 10.1038/s41598-022-20490-3)

Annese, V. F., Hu, C., Barrett, M. P., Jones, R., Cumming, D. R. S. (2022) A CMOS-based multi-omics detection platform for simultaneous quantification of proteolytically active prostate specific antigen and glutamate in urine. IEEE Sensors Journal, 22, pp. 18870-18877. (doi: 10.1109/JSEN.2022.3198282)

Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71, pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259)

Metcalfe, K. H.M., Knight, K., McIntosh, S., Hunter, R., MacKay, C., McCabe, G., Sahni, D., Ramsay, G., Roxburgh, C., Richards, C. (2022) Disease recurrence after right hemicolectomy in Scotland: Is there rationale to adopt complete mesocolic excision (CME)? Surgeon, 20, pp. 301-308. (doi: 10.1016/j.surge.2021.09.009)

May, S., Greenow, K. R., Higgins, A. T., Derrick, A. V., Taylor, E., Pan, P., Konstantinou, M., Nixon, C., Wooley, T. E., Sansom, O. J., Wang, L.-S., Parry, L. (2022) Modification of diet to reduce the stemness and tumorigenicity of murine and human intestinal cells. Molecular Nutrition and Food Research, 66, (doi: 10.1002/mnfr.202200234)

Golder, A.M., Mshihadani, A., McMillan, D.C., Horgan, P.G., Roxburgh, C.S., Mansouri, D. (2022) Route to diagnosis of colorectal cancer and association with survival within the context of a bowel screening programme. Public Health, 211, pp. 53-61. (doi: 10.1016/j.puhe.2022.06.032)

Flanagan, D. J., Woodcock, S. A., Phillips, C., Eagle, C., Sansom, O. J. (2022) Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition. Pharmacology and Therapeutics, 238, (doi: 10.1016/j.pharmthera.2022.108179)

Fisher, N. C. et al. (2022) Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data. Clinical Cancer Research, 28, pp. 4056-4069. (doi: 10.1158/1078-0432.CCR-22-1102)

Freckmann, E. C., Sandilands, E., Cumming, E., Neilson, M., Roman-Fernandez, A., Nikolatou, K., Nacke, M., Lannagan, T. R.M., Hedley, A., Strachan, D., Salji, M., Morton, J. P., McGarry, L., Leung, H. Y., Sansom, O. J., Miller, C. J., Bryant, D. M. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, (doi: 10.1038/s41467-022-32958-x)

Hanna, C.R., Lemmon, E., Hall, P.S., Ennis, H., Morris, E., McLoone, P., Boyd, K.A., Jones, R.J. (2022) Cancer trial impact: understanding implementation of the Short Course Oncology Treatment trial findings at a national level. Clinical Oncology, 34, pp. 554-560. (doi: 10.1016/j.clon.2022.03.012)

Cheong, C. M., Golder, A., Horgan, P., Roxburgh, C., McMillan, D. (2022) Relationship between pre‑operative glycated haemoglobin and surgical site infection in patients undergoing elective colon cancer surgery. Oncology Letters, 24, (doi: 10.3892/ol.2022.13416)

Alexander, P. G., Matly, A. A.M., Jirapongwattana, N., Pennel, K. A.F., Van Wyk, H. C., McMillan, D. C., Horgan, P. G., Roxburgh, C. S.D., Thuwajit, C., Roseweir, A. K., Quinn, J., Park, J. H., Edwards, J. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012)

James, N. D. et al. (2022) Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5‐year follow‐up results from the STAMPEDE randomised trial (NCT00268476) International Journal of Cancer, 151, pp. 422-434. (doi: 10.1002/ijc.34018)

Gould, L. E., Pring, E. T., Drami, I., Moorghen, M., Naghibi, M., Jenkins, J. T., Steele, C. W., Roxburgh, C. S.D. (2022) A systematic review of the pathological determinants of outcome following resection by pelvic exenteration of locally advanced and locally recurrent rectal cancer. International Journal of Surgery, 104, (doi: 10.1016/j.ijsu.2022.106738)

Yangngam, S., Prasopsiri, J., Hatthakarnkul, P., Thongchot, S., Thuwajit, P., Yenchitsomanus, P.-t., Edwards, J., Thuwajit, C. (2022) Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis. Journal of Molecular Medicine, 100, pp. 1145-1157. (doi: 10.1007/s00109-022-02228-w)

James, N. D. et al. (2022) Docetaxel for nonmetastatic prostate cancer: long-term survival outcomes in the STAMPEDE randomized controlled trial. JNCI Cancer Spectrum, 6, (doi: 10.1093/jncics/pkac043)

Chen, Z., Cordero, J., Alqarni, A. M., Slack, C., Zeidler, M. P., Bellantuono, I. (2022) Zoledronate extends health span and survival via the mevalonate pathway in a FOXO-dependent manner. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77, pp. 1494-1502. (doi: 10.1093/gerona/glab172)

Azkanaz, M., Corominas-Murtra, B., Ellenbroek, S. I.J., Bruens, L., Webb, A. T., Laskaris, D., Oost, K. C., Lafirenze, S. J.A., Annusver, K., Messal, H. A., Iqbal, S., Flanagan, D. J., Huels, D. J., Rojas-Rodríguez, F., Vizoso, M., Kasper, M., Sansom, O. J., Snippert, H. J., Liberali, P., Simons, B. D., Katajisto, P., Hannezo, E., van Rheenen, J. (2022) Retrograde movements determine effective stem cell numbers in the intestine. Nature, 607, pp. 548-554. (doi: 10.1038/s41586-022-04962-0)

Patel, R., Ford, C. A., Rodgers, L., Rushworth, L. K., Fleming, J., Mui, E., Zhang, T., Watson, D., Lynch, V., Mackay, G., Sumpton, D., Sansom, O. J., Vande Voorde, J., Leung, H. Y. (2022) Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression. Cancer Research, 82, pp. 2565-2575. (doi: 10.1158/0008-5472.CAN-21-1301)

El Helali, A., Plummer, R., Jayson, G. C., Coyle, V. M., Drew, Y., Mescallado, N., Harris, N., Clamp, A. R., McCann, J., Swaisland, H., Kennedy, R. D., Cranston, A. N., Wilson, R. H. (2022) A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours. British Journal of Cancer, 127, pp. 92-101. (doi: 10.1038/s41416-022-01780-z)

Wilson, B. E., Armstrong, A. J., de Bono, J., Sternberg, C. N., Ryan, C. J., Scher, H. I., Smith, M. R., Rathkopf, D., Logothetis, C. J., Chi, K. N., Jones, R. J., Saad, F., De Porre, P., Tran, N., Hu, P., Gillessen, S., Carles, J., Fizazi, K., Joshua, A. M. (2022) Effects of metformin and statins on outcomes in men with castration-resistant metastatic prostate cancer: Secondary analysis of COU-AA-301 and COU-AA-302. European Journal of Cancer, 170, pp. 296-304. (doi: 10.1016/j.ejca.2022.03.042)

Johnstone, M. S., Miller, G., Pang, G., Burton, P., Kouronis, G., Winter, J., Crighton, E., Mansouri, D., Witherspoon, P., Smith, K., McSorley, S. T. (2022) Alternative diagnoses and demographics associated with a raised quantitative faecal immunochemical test in symptomatic patients. Annals of Clinical Biochemistry, 59, pp. 277-287. (doi: 10.1177/00045632221076771)

Sooriakumaran, P., Wilson, C., Rombach, I., Hassanali, N., Aning, J., D. Lamb, A., Cathcart, P., Eden, C., Ahmad, I., Rajan, P., Sridhar, A., Bryant, R. J., Elhage, O., Cook, J., Leung, H., Soomro, N., Kelly, J., Nathan, S., Donovan, J. L., Hamdy, F. C. (2022) Feasibility and safety of radical prostatectomy for oligo‐metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo‐Metastases to the bone (TRoMbone) trial. BJU International, 130, pp. 43-53. (doi: 10.1111/bju.15669)

Gillessen, S. et al. (2022) Management of patients with advanced prostate cancer: report from the advanced prostate cancer consensus conference 2021. European Urology, 82, pp. 115-141. (doi: 10.1016/j.eururo.2022.04.002)

McGovern, J., Golder, A. M., Dolan, R. D., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2022) The combination of computed tomography-derived muscle mass and muscle density and relationship with clinicopathological characteristics and survival in patients undergoing potentially curative surgery for colorectal cancer. JCSM Clinical Reports, 7, pp. 65-76. (doi: 10.1002/crt2.54)

Shamis, S. A.K., Quinn, J., Mallon, E. E.A., Edwards, J., McMillan, D. C. (2022) The relationship between the tumor cell expression of hypoxic markers and survival in patients with ER-positive invasive ductal breast cancer. Journal of Histochemistry and Cytochemistry, 70, pp. 479-494. (doi: 10.1369/00221554221110280)

Turco, F. et al. (2022) What experts think about prostate cancer management during the COVID-19 pandemic: report from the Advanced Prostate Cancer Consensus Conference 2021. European Urology, 82, pp. 6-11. (doi: 10.1016/j.eururo.2022.02.010)

Evans, J., Keith, N., Paul, J. (2022) An analysis of Relative Telomere Length (RTL) during chemotherapy in patients with advanced gastro-oesophageal adenocarcinoma. (doi: 10.17504/protocols.io.n92ldznenv5b/v1)

Catto, J. W. F. et al. (2022) Effect of robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy on 90-day morbidity and mortality among patients with bladder cancer. JAMA: Journal of the American Medical Association, 327, pp. 2092-2103. (doi: 10.1001/jama.2022.7393)

Parker, C. C. et al. (2022) Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial. PLoS Medicine, 19, (doi: 10.1371/journal.pmed.1003998)

Clarke, C. S., Hunter, R. M., Gabrio, A., Brawley, C. D., Ingleby, F. C., Dearnaley, D. P., Matheson, D., Attard, G., Rush, H. L., Jones, R. J., Cross, W., Parker, C., Russell, J. M., Millman, R., Gillessen, S., Malik, Z., Lester, J. F., Wylie, J., Clarke, N. W., Parmar, M. K. B., Sydes, M. R., James, N. D. (2022) Cost-utility analysis of adding abiraterone acetate plus prednisone/prednisolone to long-term hormone therapy in newly diagnosed advanced prostate cancer in England: Lifetime decision model based on STAMPEDE trial data. PLoS ONE, 17, (doi: 10.1371/journal.pone.0269192)

Patel, M., Pennel, K. A.F., Quinn, J. A., Hood, H., Chang, D. K., Biankin, A. V., Rebus, S., Roseweir, A. K., Park, J. H., Horgan, P. G., McMillan, D. C., Edwards, J. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126, pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4, pp. 693-710. (doi: 10.1038/s42255-022-00582-0)

Zaweia, R., McMenemy, C., Quinn, J., Greenhalgh, D. (2022) E-cadherin Loss Cooperates with RasHa Activation to Drive Malignant Progression in Transgenic Mouse Skin Carcinogenesis. (doi: 10.1111/bjd.21248)

Kidger, A. M., Saville, M. K., Rushworth, L. K., Davidson, J., Stellzig, J., Ono, M., Kuebelsbeck, L. A., Janssen, K.-P., Holzmann, B., Morton, J. P., Sansom, O. J., Caunt, C. J., Keyse, S. M. (2022) Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene, 41, pp. 2811-2823. (doi: 10.1038/s41388-022-02302-0)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Hussain, S. A., Lester, J. F., Jackson, R., Gornall, M., Qureshi, M., Elliott, A., Crabb, S. J., Huddart, R. A., Vasudev, N., Birtle, A. J., Worlding, J., James, N. D., Parikh, O., Vilarino-Varela, M., Alonz, R., Linch, M. D., Riaz, I. B., Catto, J. W. F., Powles, T., Jones, R. J. (2022) Addition of nintedanib or placebo to neoadjuvant gemcitabine and cisplatin in locally advanced muscle-invasive bladder cancer (NEOBLADE): a double-blind, randomised, phase 2 trial. Lancet Oncology, 23, pp. 650-658. (doi: 10.1016/S1470-2045(22)00158-9)

Lawrence, M., Wiesheu, R., Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, (doi: 10.1016/j.biocel.2022.106213)

Dinneen, E. et al. (2022) Negative mpMRI rules out extra-prostatic extension in prostate cancer before robot-assisted radical prostatectomy. Diagnostics, 12, (doi: 10.3390/diagnostics12051057)

Ross, F. A., Park, J. H., Mansouri, D., Combet, E., Horgan, P. G., McMillan, D. C., Roxburgh, C. S.D. (2022) The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterology, 22, (doi: 10.1186/s12876-022-02220-1)

Brown, L. C., Graham, J., Fisher, D., Adams, R., Seligmann, J., Seymour, M., Kaplan, R., Yates, E., Parmar, M., Richman, S. D., Quirke, P., Butler, R., Shiu, K., Middleton, G., Samuel, L., Wilson, R. H., Maughan, T. S. (2022) Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer. Clinical Trials, 19, pp. 146-157. (doi: 10.1177/17407745211069879)

Hatthakarnkul, P., Quinn, J. A., Ammar, A., Lynch, G., Van Wyk, H., McMillan, D. C., Thuwajit, C., Edwards, J. (2022) Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer. Clinical Science, 136, pp. 521-535. (doi: 10.1042/CS20210886)

Dunlop, E., Ferguson, A., Mueller, T., Baillie, K., Clarke, J., Laskey, J., Kurdi, A., Wu, O., Jones, R., Glen, H., Bennie, M. (2022) What matters to patients and clinicians when discussing the impact of cancer medicines on health-related quality of life? Consensus-based mixed methods approach in prostate cancer. Supportive Care in Cancer, 30, pp. 3141-3150. (doi: 10.1007/s00520-021-06724-6)

Golder, A. M., McMillan, D. C., Horgan, P. G., Roxburgh, C. S.D. (2022) Determinants of emergency presentation in patients with colorectal cancer: a systematic review and meta-analysis. Scientific Reports, 12, (doi: 10.1038/s41598-022-08447-y)

Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14, (doi: 10.15252/emmm.202114764)

Ross, F. A., Park, J. H., Mansouri, D., Little, C., Di Rollo, D. G., Combet, E., Van Wyk, H., Horgan, P. G., McMillan, D. C., Roxburgh, C. S. D. (2022) The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy. Colorectal Disease, 24, pp. 188-196. (doi: 10.1111/codi.15942)

Medina, A., Bellec, K., Polcownuk, S., Cordero, J. B. (2022) Investigating local and systemic intestinal signalling in health and disease with Drosophila. Disease Models and Mechanisms, 15, (doi: 10.1242/dmm.049332)

Glen, C., Tan, Y. Y., Waterston, A., Evans, T. R. J., Jones, R. J., Petrie, M. C., Lang, N. N. (2022) Mechanistic and clinical overview cardiovascular toxicity of BRAF and MEK inhibitors: JACC: CardioOncology state-of-the-art review. JACC: CardioOncology, 4, pp. 1-18. (doi: 10.1016/j.jaccao.2022.01.096)

Zaborowski, A. M. et al. (2022) Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response. British Journal of Surgery, 109, pp. 251-255. (doi: 10.1093/bjs/znab437)

Walter, R. J., Sonnentag, S. J., Munoz-Sagredo, L., Merkel, M., Richert, L., Bunert, F., Heneka, Y. M., Loustau, T., Hodder, M., Ridgway, R. A., Sansom, O. J., Mely, Y., Rothbauer, U., Schmitt, M., Orian-Rousseau, V. (2022) Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop. Cell Death and Disease, 13, (doi: 10.1038/s41419-022-04607-0)

Johnstone, M. S., Burton, P., Kourounis, G., Winter, J., Crighton, E., Mansouri, D., Witherspoon, P., Smith, K., McSorley, S. T. (2022) Combining the quantitative faecal immunochemical test and full blood count reliably rules out colorectal cancer in a symptomatic patient referral pathway. International Journal of Colorectal Disease, 37, pp. 457-466. (doi: 10.1007/s00384-021-04079-2)

Roman Fernandez, A., Sandilands, E., Bryant, D. M. (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. Springer

Attard, G. et al. (2022) Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol. Lancet, 399, pp. 447-460. (doi: 10.1016/S0140-6736(21)02437-5)

Strittmatter, N. et al. (2022) Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging. Analytical Chemistry, 94, pp. 1795-1803. (doi: 10.1021/acs.analchem.1c04579)

Mueller, T., Laskey, J., Baillie, K., Clarke, J., Crearie, C., Kavanagh, K., Graham, J., Graham, K., Waterson, A., Jones, R., Kurdi, A., Morrison, D., Bennie, M. (2022) Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice. Health Informatics Journal, 28, pp. 14604582221077055. (doi: 10.1177/14604582221077055)

Paterson, K., Paterson, S., Mulholland, T., Coffelt, S.B., Zagnoni, M. (2022) Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy. IEEE Open Journal of Engineering in Medicine and Biology, 3, pp. 86-95. (doi: 10.1109/OJEMB.2022.3178302)

Cheong, C. M., Golder, A. M., Horgan, P. D., McMillan, D. C., Roxburgh, C. S.D. (2022) Evaluation of clinical prognostic variables on short-term outcome for colorectal cancer surgery: an overview and minimum dataset. Cancer Treatment and Research Communications, 31, (doi: 10.1016/j.ctarc.2022.100544)

Curio, S., Edwards, S. C., Suzuki, T., McGovern, J., Triulzi, C., Yoshida, N., Jonsson, G., Glauner, T., Rami, D., Wiesheu, R., Kilbey, A., Purcell, R. V., Coffelt, S. B., Guerra, N. (2022) NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1, (doi: 10.1093/discim/kyac002)

Love, S. B. et al. (2022) Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units. Trials, 23, (doi: 10.1186/s13063-022-06680-4)

Knight, J. R.P., Vlahov, N., Gay, D. M., Ridgway, R. A., Faller, W. J., Proud, C., Mallucci, G. R., von der Haar, T., Smales, C. M., Willis, A. E., Sansom, O. J. (2021) Rpl24 Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K. eLife, 10, (doi: 10.7554/elife.69729)

Falcomata, C. et al. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. Cancer Discovery, 11, pp. 3158-3177. (doi: 10.1158/2159-8290.CD-21-0209)

van Winsen, M., McSorley, S. T., McLeod, R., MacDonald, A., Forshaw, M. J., Shaw, M., Puxty, K. (2021) Postoperative C-reactive protein concentrations to predict infective complications following gastrectomy for cancer. Journal of Surgical Oncology, 124, pp. 1060-1069. (doi: 10.1002/jso.26613)

Johnson, S. A., Ormsby, M. J., Wessel, H., Hulme, H., Bravo-Blas, A., McIntosh, A., Mason, S., Coffelt, S., Tait, S. W.G., Mcl. Mowat, A., Milling, S., Blyth, K., Wall, D. M. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51, pp. 3228-3238. (doi: 10.1002/eji.202048913)

Adams, R. A., Fisher, D. J., Graham, J., Seligmann, J. F., Seymour, M., Kaplan, R., Yates, E., Parmar, M., Richman, S. D., Quirke, P., Butler, R., Brown, E., Collinson, F., Falk, S., Wasan, H., Shiu, K.-K., Middleton, G., Samuel, L., Wilson, R. H., Brown, L. C., Maughan, T. S. (2021) Capecitabine versus active monitoring in stable or responding metastatic colorectal cancer after 16 weeks of first-line therapy: results of the randomized FOCUS4-N trial. Journal of Clinical Oncology, 39, pp. 3693-3704. (doi: 10.1200/JCO.21.01436)

Heino, S., Fang, S., Lähde, M., Högström, J., Nassiri, S., Campbell, A., Flanagan, D., Raven, A., Hodder, M., Nasreddin, N., Xue, H.-H., Delorenzi, M., Leedham, S., Petrova, T. V., Sansom, O., Alitalo, K. (2021) Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science Advances, 7, (doi: 10.1126/sciadv.abj0512)

O'Connor, M. N., Kallenberg, D. M., Camilli, C., Pilotti, C., Dritsoula, A., Jackstadt, R., Bowers, C. E., Watson, H. A., Alatsatianos, M., Ohme, J., Dowsett, L., George, J., Blackburn, J. W.D., Wang, X., Singhal, M., Augustin, H. G., Ager, A., Sansom, O. J., Moss, S. E., Greenwood, J. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2, pp. 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002)

Nicoll, R., White, M., Loureiro Harrison, L., Cordiner, R. L.M., Daniel, M., Choo-Kang, B., Boyle, J. G. (2021) Improving the quality of weekend medical handover on non-receiving medical hospital wards. BMJ Open Quality, 10, (doi: 10.1136/bmjoq-2020-000991)

Hernon, J., Jones, M., Howard, G., Swart, A. M., Clark, A., Stirling, S., Turner, D., Murdoch, J., Nortje, J., Bach, S., Fearnhead, N., Din, F., Stephens, A., Lund, J., Tou, S., Kelly, S., Ziprin, P., Dennis, R., Smart, N., Roxburgh, C., Simpson, A., Mishra, A., Knight, K., Dresser, K. (2021) SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): pilot phase of a multicentre randomised controlled trial. Colorectal Disease, 23, pp. 3008-3022. (doi: 10.1111/codi.15856)

Knight, K. A., Drami, I., McMillan, D. C., Horgan, P. G., Park, J. H., Jenkins, J. T., Roxburgh, C. S.D. (2021) Vascular calcification and response to neoadjuvant therapy in locally advanced rectal cancer: an exploratory study. Journal of Cancer Research and Clinical Oncology, 147, pp. 3409-3420. (doi: 10.1007/s00432-021-03570-1)

Murphy, K. J. et al. (2021) Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Science Advances, 7, (doi: 10.1126/sciadv.abh0363)

Lampis, A., Hahne, J. C., Gasparini, P., Cascione, L., Hedayat, S., Vlachogiannis, G., Murgia, C., Fontana, E., Edwards, J., Horgan, P. G., Terracciano, L., Sansom, O. J., Martins, C. D., Kramer-Marek, G., Croce, C. M., Braconi, C., Fassan, M., Valeri, N. (2021) MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer. Cell Death and Differentiation, 28, pp. 2970-2982. (doi: 10.1038/s41418-021-00820-0)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16, pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018)

Halabi, S., Yang, Q., Carmack, A., Zhang, S., Foo, W.-C., Eisen, T., Stadler, W., Jones, R. J., Garcia, J., Picus, J., Hawkins, R., Hainsworth, J., Kollmannsberger, C., Logan, T., Puzanov, I., Pickering, L., Ryan, C., Protheroe, A., George, D., Armstrong, A. (2021) Tissue based biomarkers in non-clear cell RCC: Correlative analysis from the ASPEN clinical trial. Kidney Cancer Journal, 19, pp. 64-72. (doi: 10.52733/kcj19n3-a1)

Zaborowski, A. M. et al. (2021) Characteristics of early-onset vs late-onset colorectal cancer. JAMA Surgery, 156, pp. 865-874. (doi: 10.1001/jamasurg.2021.2380)

Xiong, Z., Jeon, M., Allaway, R. J., Kang, J., Park, D., Lee, J., Jeon, H., Ko, M., Jiang, H., Zheng, M., Tan, A. C., Guo, X., Dang, K. K., Tropsha, A., Hecht, C., Das, T. K., Carlson, H. A., Abagyan, R., Guinney, J., Schlessinger, A., Cagan, R. (2021) Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge. PLoS Computational Biology, 17, (doi: 10.1371/journal.pcbi.1009302)

Chan, B. Y.L., McKinlay, S., Forshaw, M., Macdonald, A., Maitra, R., Orizu, M., McSorley, S. T. (2021) Impact of anaemia in oesophago-gastric cancer patients undergoing curative treatment by means of neoadjuvant chemotherapy and surgery. Surgical Oncology, 38, (doi: 10.1016/j.suronc.2021.101585)

Stonier, T. et al. (2021) The "Is mpMRI Enough" or IMRIE Study: a multicentre evaluation of prebiopsy multiparametric magnetic resonance imaging compared with biopsy. European Urology Focus, 7, pp. 1027-1034. (doi: 10.1016/j.euf.2020.09.012)

Massanova, M., Robertson, S., Barone, B., Butto, L., Caputo, V. F., Bhatt, J. R., Ahmad, I., Bada, M., Obeidallah, A., Crocetto, F. (2021) The comparison of imaging and clinical methods to estimate prostate volume: a single-centre retrospective study. Urologia Internationalis, 105, pp. 804-810. (doi: 10.1159/000516681)

Hanna, C. R., Robles-Zurita, J. A., Briggs, A., Harkin, A., Kelly, C., McQueen, J., Allan, K., Pearson, S., Hollander, N. H., Glimelius, B., Salazar, R., Segelov, E., Saunders, M., Iveson, T., Jones, R. J., Boyd, K. A. (2021) Three versus six months of adjuvant doublet chemotherapy for patients with colorectal cancer: a multi-country cost-effectiveness and budget impact analysis. Clinical Colorectal Cancer, 20, pp. 236-244. (doi: 10.1016/j.clcc.2021.04.001)

Hanna, C. R., O'Cathail, S. M., Graham, J. S., Saunders, M., Samuel, L., Harrison, M., Devlin, L., Edwards, J., Gaya, D. R., Kelly, C. A., Lewsley, L.-A., Maka, N., Morrison, P., Dinnett, L., Dillon, S., Gourlay, J., Platt, J. J., Thomson, F., Adams, R. A., Roxburgh, C. S.D. (2021) Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT) Radiation Oncology, 16, (doi: 10.1186/s13014-021-01888-1)

Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, (doi: 10.1038/s41467-021-25173-7)

Hodgson, J. A., Parvy, J.-P., Yu, Y., Vidal, M., Cordero, J. B. (2021) Drosophila larval models of invasive tumorigenesis for in vivo studies on tumour/peripheral host tissue interactions during cancer cachexia. International Journal of Molecular Sciences, 22, (doi: 10.3390/ijms22158317)

Johnstone, M. S., Lynch, G., Park, J., McSorley, S., Edwards, J. (2021) Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review. Critical Reviews in Oncology/Haematology, 164, (doi: 10.1016/j.critrevonc.2021.103421)

Ntala, C., Salji, M., Salmond, J., Officer, L., Teodosio, A. V., Blomme, A., McGhee, E. J., Powley, I., Ahmad, I., Kruithof-de Julio, M., Thalmann, G., Roberts, E., Goodyear, C. S., Jamaspishvili, T., Berman, D. M., Carlin, L. M., Le Quesne, J., Leung, H. Y. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001)

Welisch, G., Twelves, C., Plummer, R., Evans, J., Danson, S., Symeonides, S., Halsey, C., Jones, R., Hanna, C., Gallagher, P., Walls, G., Taylor, K., Barnett, S., Forde, C., White, M., Williams, C., El Badri, S., Chipole, B.'e. D., Keith, N. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? (doi: 10.17605/OSF.IO/KWHQF)

Galbraith, N. J., Wood, C., Steele, C. W. (2021) Targeting metastatic colorectal cancer with immune oncological therapies. Cancers, 13, (doi: 10.3390/cancers13143566)

Mansouri, D., McSorley, S. T., Park, J. H., Orange, C., Horgan, P. G., McMillan, D. C., Edwards, J. (2021) The inflammatory microenvironment in screen-detected premaligant adenomatous polyps: early results from the integrated technologies for improved polyp surveillance (INCISE) project. European Journal of Gastroenterology and Hepatology, 33, pp. 983-989. (doi: 10.1097/MEG.0000000000002202)

Matly, A., Quinn, J. A., McMillan, D. C., Park, J. H., Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, (doi: 10.1016/j.critrevonc.2021.103337)

McSorley, S. T., Digby, J., Clyde, D., Cruickshank, N., Burton, P., Barker, L., Strachan, J. A., Fraser, C. G., Smith, K., Mowat, C., Winter, J., Steele, R. J.C. (2021) Yield of colorectal cancer at colonoscopy according to faecal haemoglobin concentration in symptomatic patients referred from primary care. Colorectal Disease, 23, pp. 1615-1621. (doi: 10.1111/codi.15405)

Paterson, K., Zanivan, S., Glasspool, R., Coffelt, S.B., Zagnoni, M. (2021) Microfluidic technologies for immunotherapy studies on solid tumours. Lab on a Chip, 21, pp. 2306-2329. (doi: 10.1039/D0LC01305F)

Nászai, M., Bellec, K., Yu, Y., Román-Fernández, Á., Sandilands, E., Johansson, J., Campbell, A. D., Norman, J. C., Sansom, O. J., Bryant, D. M., Cordero, J. B. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, (doi: 10.7554/eLife.63807)

Flanagan, D. J. et al. (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature, 594, pp. 430-435. (doi: 10.1038/s41586-021-03525-z)

Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, (doi: 10.1038/s41467-021-23717-5)

Nielsen, S. R., Strøbech, J. E., Horton, E. R., Jackstadt, R., Laitala, A., Bravo, M. C., Maltese, G., Jensen, A. R. D., Reuten, R., Rafaeva, M., Karim, S. A., Hwang, C.-I., Arnes, L., Tuveson, D. A., Sansom, O. J., Morton, J. P., Erler, J. T. (2021) Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature Communications, 12, (doi: 10.1038/s41467-021-23731-7)

Armstrong, A. J., Nixon, A. B., Carmack, A., Eisen, T., Stadler, W. M., Jones, R. J., Garcia, J. A., Vaishampayan, U. N., Picus, J., Hawkins, R. E., Hainsworth, J. D., Kollmannsberger, C. K., Logan, T. F., Puzanov, I., Pickering, L. M., Ryan, C. W., Protheroe, A., George, D. J., Halabi, S. (2021) Angiokines associated with outcomes after sunitinib or everolimus treatment in patients with non-clear cell renal cell carcinoma. Clinical Cancer Research, 27, pp. 3317-3328. (doi: 10.1158/1078-0432.CCR-20-4504)

Knight, K. A., Hon Fei, C., Boland, K. F., Dolan, D. R., Golder, A. M., McMillan, D. C., Horgan, P. G., Black, D. H., Park, J. H., Roxburgh, C. S.D. (2021) Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study. European Radiology, 31, pp. 4319-4329. (doi: 10.1007/s00330-020-07189-7)

Powles, T., Carroll, D., Chowdhury, S., Gravis, G., Joly, F., Carles, J., Fléchon, A., Maroto, P., Petrylak, D., Rolland, F., Cook, N., Balar, A. V., Sridhar, S. S., Galsky, M. D., Grivas, P., Ravaud, A., Jones, R., Cosaert, J., Hodgson, D., Kozarewa, I., Mather, R., McEwen, R., Mercier, F., Landers, D. (2021) An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer. Nature Medicine, 27, pp. 793-801. (doi: 10.1038/s41591-021-01317-6)

Perochon, J., Yu, Y., Aughey, G. N., Medina, A. B., Southall, T. D., Cordero, J. B. (2021) Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila. Nature Cell Biology, 23, pp. 485-496. (doi: 10.1038/s41556-021-00676-z)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11, pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652)

Moreno, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A. T., Edwards, J., de la Vega, L. (2021) The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. Cell Death and Differentiation, 28, pp. 1563-1578. (doi: 10.1038/s41418-020-00686-8)

Gudiño, V., Pohl, S. Ö.-G., Billard, C. V., Cammareri, P., Bolado, A., Aitken, S., Stevenson, D., Hall, A. E., Agostino, M., Cassidy, J., Nixon, C., Von Kriegsheim, A., Freile, P., Popplewell, L., Dickson, G., Murphy, L., Wheeler, A., Dunlop, M., Din, F., Strathdee, D., Sansom, O. J., Myant, K. B. (2021) RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nature Communications, 12, (doi: 10.1038/s41467-021-22531-3)

Galbraith, L. C.A., Mui, E., Nixon, C., Hedley, A., Strachan, D., MacKay, G., Sumpton, D., Sansom, O. J., Leung, H. Y., Ahmad, I. (2021) PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene, 40, pp. 2355-2366. (doi: 10.1038/s41388-021-01707-7)

Rosenfeldt, M. T., O’Prey, J., Lindsay, C. R., Nixon, C., Roth, S., Sansom, O. J., Ryan, K. (2021) Loss of autophagy affects melanoma development in a manner dependent on PTEN status. Cell Death and Differentiation, 28, pp. 1437-1439. (doi: 10.1038/s41418-021-00746-7)

Hanna, C., Lemmon, E., Ennis, H., Jones, R., Hay, J., Halliday, R., Clark, S., Morris, E., Hall, P. (2021) Creation of the first national linked colorectal cancer dataset in Scotland: prospects for future research and a reflection on lessons learned. International Journal of Population Data Science, 6, (doi: 10.23889/ijpds.v6i1.1654)

van der Weyden, L., Harle, V., Turner, G., Offord, V., Iyer, V., Droop, A., Swiatkowska, A., Rabbie, R., Campbell, A. D., Sansom, O. J., Pardo, M., Choudhary, J. S., Ferreira, I., Tullett, M., Arends, M. J., Speak, A. O., Adams, D. J. (2021) CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Communications Biology, 4, (doi: 10.1038/s42003-021-01912-w)

Hanna, C. R., Robb, K. A., Blyth, K. G., Jones, R. J., Chalmers, A. J. (2021) Clinician attitudes to using low dose radiotherapy to treat COVID-19 lung disease. International Journal of Radiation Oncology, Biology, Physics, 109, pp. 886-890. (doi: 10.1016/j.ijrobp.2020.12.003)

McFarlane, A. J., Fercoq, F., Coffelt, S. B., Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131, (doi: 10.1172/JCI143759)

Nacke, M., Sandilands, E., Nikolatou, K., Román-Fernández, Á., Mason, S., Patel, R., Lilla, S., Yelland, T., Galbraith, L. C.A., Freckmann, E. C., McGarry, L., Morton, J. P., Shanks, E., Leung, H. Y., Markert, E., Ismail, S., Zanivan, S., Blyth, K., Bryant, D. M. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, (doi: 10.1038/s41467-021-21847-4)

Hanna, C. R., Boyd, K. A., Jones, R. J. (2021) Evaluating cancer research impact: lessons and examples from existing reviews on approaches to research impact assessment. Health Research Policy and Systems, 19, (doi: 10.1186/s12961-020-00658-x)

Annese, V. F., Patil, S. B., Hu, C., Giagkoulovits, C., Al-Rawhani, M. A., Grant, J., Macleod, M., Clayton, D.J., Heaney, L.M., Daly, R., Accarino, C., Shah, Y. D., Cheah, B. C., Beeley, J., Evans, T.R.J., Jones, R., Barrett, M. P., Cumming, D. R.S. (2021) A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems and Nanoengineering, 7, (doi: 10.1038/s41378-021-00243-4)

Al-Badran, S. S.F., Grant, L., Campo, M. B., Inthagard, J., Pennel, K., Quinn, J., Konanahalli, P., Hayman, L., Horgan, P. G., McMillan, D. C., Roxburgh, C. S.D., Roseweir, A., Park, J. H., Edwards, J. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7, pp. 121-134. (doi: 10.1002/cjp2.193)

Sphyris, N., Hodder, M. C., Sansom, O. J. (2021) Subversion of niche-signalling pathways in colorectal cancer: what makes and breaks the intestinal stem cell. Cancers, 13, (doi: 10.3390/cancers13051000)

Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F., Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J., Machesky, L. M. (2021) The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice. Journal of Investigative Dermatology, 141, pp. 628-637.e15. (doi: 10.1016/j.jid.2020.06.029)

Shamis, S. A. K., McMillan, D. C., Edwards, J. (2021) The relationship between Hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 159, (doi: 10.1016/j.critrevonc.2021.103231)

Race, A. M., Sutton, D., Hamm, G., Maglennon, G., Morton, J. P., Strittmatter, N., Campbell, A., Sansom, O. J., Wang, Y., Barry, S. T., Takáts, Z., Goodwin, R. J.A., Bunch, J. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93, pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726)

Keith, N., Plummer, R., Coyle, V., Cameron, D., Evans, J., Twelves, C., Palmer, D., Danson, S., Graham, D., Welisch, G. (2021) Early Phase Cancer Research in the COVID-19 Pandemic: an ECMC North Initiative. (doi: 10.17605/OSF.IO/6WTN2)

Murta, T., Steven, R. T., Nikula, C. J., Thomas, S. A., Zeiger, L. B., Dexter, A., Elia, E. A., Yan, B., Campbell, A. D., Goodwin, R. J.A., Takáts, Z., Sansom, O. J., Bunch, J. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93, pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179)

Hartley, A., Leung, H. Y., Ahmad, I. (2021) Targeting the BAF complex in advanced prostate cancer. Expert Opinion on Drug Discovery, 16, pp. 173-181. (doi: 10.1080/17460441.2020.1821644)

McSorley, S. T., Steele, C. W., Anderson, J. H., McKinlay, S. (2021) Comment on 'Preoperative intravenous iron therapy and survival after colorectal cancer surgery: long term results from the IVICA randomised controlled trial' Colorectal Disease, 23, pp. 555-556. (doi: 10.1111/codi.15428)

Knight, K., Al-Wahid, M., Choong, J. X., Burton, K., Lindsay, R., McKee, R. F., Anderson, J. H., Roxburgh, C. S.D. (2021) Multidisciplinary management of anal intraepithelial neoplasia and rate of progression to cancer: a retrospective cohort study. European Journal of Surgical Oncology, 47, pp. 304-310. (doi: 10.1016/j.ejso.2020.08.011)

McSorley, S. T., Lau, H. Y.N., McIntosh, D., Forshaw, M. J., McMillan, D. C., Crumley, A. B. (2021) Staging the tumour and staging the host: Pre-treatment combined Neutrophil Lymphocyte Ratio and modified Glasgow Prognostic Score is associated with overall survival in patients with oesophagogastric cancers undergoing treatment with curative intent. Annals of Surgical Oncology, 28, pp. 722-731. (doi: 10.1245/s10434-020-09074-5)

Crabb, S. J., Griffiths, G., Marwood, E., Dunkley, D., Downs, N., Martin, K., Light, M., Northey, J., Wilding, S., Whitehead, A., Shaw, E., Birtle, A. J., Bahl, A., Elliott, T., Westbury, C., Sundar, S., Robinson, A., Jagdev, S., Kumar, S., Rooney, C., Salinas-Souza, C., Stephens, C., Khoo, V., Jones, R. J. (2021) Pan-AKT inhibitor capivasertib with docetaxel and prednisolone in metastatic castration-resistant prostate cancer: a randomized, placebo-controlled phase II trial (ProCAID) Journal of Clinical Oncology, 39, pp. 190-201. (doi: 10.1200/JCO.20.01576)

Alhayyan, A. M., McSorley, S. T., Kearns, R. J., Horgan, P. G., Roxburgh, C. S.D., McMillan, D. C. (2021) The effect of anesthesia on the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colorectal cancer in the context of an enhanced recovery pathway: A prospective cohort study. Medicine, 100, (doi: 10.1097/MD.0000000000023997)

Tajan, M., Hennequart, M., Cheung, E. C., Zani, F., Hock, A. K., Legrave, N., Maddocks, O. D.K., Ridgway, R. A., Athineos, D., Suárez-Bonnet, A., Ludwig, R. L., Novellasdemunt, L., Angelis, N., Li, V. S.W., Vlachogiannis, G., Valeri, N., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M., Blyth, K., Sansom, O. J., Vousden, K. H. (2021) Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12, (doi: 10.1038/s41467-020-20223-y)

Padash Barmchi, M., Thomas, M., Thatte, J. V., Vats, A., Zhang, B., Cagan, R. L., Banks, L. (2021) Inhibition of kinase IKK β suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6. Scientific Reports, 11, (doi: 10.1038/s41598-020-80193-5)

Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3)

Edwards, S. C., Hoevenaar, W. H.M., Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5)

Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, (doi: 10.1038/s41467-020-20255-4)

Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160, pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043)

Lähde, M., Heino, S., Högström, J., Kaijalainen, S., Anisimov, A., Flanagan, D., Kallio, P., Leppänen, V.-M., Ristimäki, A., Ritvos, O., Wu, K., Tammela, T., Hodder, M., Sansom, O. J., Alitalo, K. (2021) Expression of R-spondin 1 in Apc^Min/+ mice suppresses growth of intestinal adenomas by altering Wnt and transforming growth factor beta signaling. Gastroenterology, 160, pp. 245-259. (doi: 10.1053/j.gastro.2020.09.011)

Knight, K., Choong, J.X., McKee, R.F., Anderson, J.H., Horgan, P.G., McMillan, D.C., McDonald, A., Roxburgh, C.S. (2021) The influence of systemic inflammation on treatment response and survival in anal squamous cell cancer. Clinical Oncology, 33, pp. e22-e30. (doi: 10.1016/j.clon.2020.06.010)

Hanna, C. R., Boyd, K. A., Wincenciak, J., Graham, J., Iveson, T., Jones, R. J., Wilson, R. (2021) Do clinical trials change practice? A longitudinal, international assessment of colorectal cancer prescribing practices. Cancer Treatment and Research Communications, 28, (doi: 10.1016/j.ctarc.2021.100445)

Hanna, C. R., O'Cathail, S. M., Graham, J., Adams, R., Roxburgh, C. S.D. (2021) Immune checkpoint inhibition as a strategy in the neoadjuvant treatment of locally advanced rectal cancer. Journal of Immunotherapy and Precision Oncology, 4, (doi: 10.36401/JIPO-20-31)

Hatthakarnkul, P., Quinn, J. A., Matly, A. A. M., Ammar, A., Van Wyk, H. C., McMillan, D. C., Edwards, J. (2021) Systematic review of tumour budding and association with common mutations in patients with colorectal cancer. Critical Reviews in Oncology/Hematology, 167, (doi: 10.1016/j.critrevonc.2021.103490)

McAllister, M. J., McCall, P., Dickson, A., Underwood, M. A., Andersen, D., Holmes, E., Market, E., Leung, H. Y., Edwards, J. (2020) Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer. Prostate Cancer and Prostatic Diseases, 23, pp. 596-606. (doi: 10.1038/s41391-020-0235-1)

Dolan, R. D., Maclay, J. D., Abbass, T., Colville, D., Buali, F., MacLeod, N., McSorley, S. T., Horgan, P. G., McMillan, D. C. (2020) The relationship between 18F-FDG-PETCT-derived tumour metabolic activity, nutritional risk, body composition, systemic inflammation and survival in patients with lung cancer. Scientific Reports, 10, (doi: 10.1038/s41598-020-77269-7)

Malviya, G., Patel, R., Salji, M., Martinez, R. S., Repiscak, P., Mui, E., Champion, S., Mrowinska, A., Johnson, E., AlRasheedi, M., Pimlott, S., Lewis, D., Leung, H. Y. (2020) 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy. EJNMMI Research, 10, (doi: 10.1186/s13550-020-00728-9)

Coffelt, S. B., Kabelitz, D., Silva-Santos, B., Kuball, J., Born, W., Bank, I. (2020) Editorial: γδ T Cells in Cancer. Frontiers in Immunology, 11, (doi: 10.3389/fimmu.2020.602411)

Hanna, C. R., Blyth, K. G., Burley, G., Carmichael, S., Evans, C., Hinsley, S., Khadra, I., Khoo, S., Lewsley, L.-A., Jones, R. R., Sharma, R., Taladriz-Sender, A., Thomson, E. C., Scott, J. T. (2020) Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19: A structured summary of a study protocol for a randomised controlled trial. Trials, 21, (doi: 10.1186/s13063-020-04891-1)

McAllister, M., Constancio, V., Patek, S., Gan, H., Bailey, P., Wheadon, H., Underwood, M., Leung, H., Edwards, J. (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80, pp. 1353-1364. (doi: 10.1002/pros.24064)

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J., Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298, pp. 198-217. (doi: 10.1111/imr.12916)

Savioli, F., Edwards, J., McMillan, D., Stallard, S., Doughty, J., Romics, L. (2020) The effect of postoperative complications on survival and recurrence after surgery for breast cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 155, (doi: 10.1016/j.critrevonc.2020.103075)

Dolan, R. D., Alwahid, M., McSorley, S. T., Park, J. H., Stevenson, R. P., Roxburgh, C. S., Horgan, P. G., McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, (doi: 10.1038/s41598-020-73909-0)

Mevel, R., Steiner, I., Mason, S., Galbraith, L. C.A., Patel, R., Fadlullah, M. Z.H., Ahmad, I., Leung, H. Y., Oliveira, P., Blyth, K., Baena, E., Lacaud, G. (2020) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. eLife, 9, (doi: 10.7554/elife.60225)

Alexander, P.G., Roseweir, A.K., Pennel, K.A.F., van Wyk, H.C., Powell, A.G.M.T., McMillan, D.C., Horgan, P.G., Kelly, C., Hay, J., Sansom, O., Harkin, A., Roxburgh, C.S.D., Graham, J., Church, D.N., Tomlinson, I., Saunders, M., Iveson, T.J., Edwards, J., Park, J.H. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x)

Montes, M., MacKenzie, L., McAllister, M.J., Roseweir, A., McCall, P., Hatziieremia, S., Underwood, M.A., Boyd, M., Paul, A., Plevin, R., MacKay, S.P., Edwards, J. (2020) Determining the prognostic significance of IKKα in prostate cancer. Prostate, 80, pp. 1188-1202. (doi: 10.1002/pros.24045)

Mariappan, P., Johnston, A., Padovani, L., Clark, E., Trail, M., Hamid, S., Hollins, G., Simpson, H., Thomas, B. G., Hasan, R., Bhatt, J., Ahmad, I., Nandwani, G. M., Mitchell, I. D.C., Hendry, D. (2020) Enhanced quality and effectiveness of transurethral resection of bladder tumour in non–muscle-invasive bladder cancer: a multicentre real-world experience from Scotland’s Quality Performance Indicators programme. European Urology, 78, pp. 520-530. (doi: 10.1016/j.eururo.2020.06.051)

Roseweir, A. K., Park, J. H., ten Hoorn, S., Powell, A. G.M.T., Aherne, S., Roxburgh, C. S.D., McMillan, D. C., Horgan, P. G., Ryan, E., Sheahan, K., Vermeulen, L., Paul, J., Harkin, A., Graham, J., Sansom, O., Church, D. N., Tomlinson, I., Saunders, M., Iveson, T. J., Edwards, J. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6, pp. 283-296. (doi: 10.1002/cjp2.171)

Torrente, L., Maan, G., Oumkaltoum Rezig, A., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. T., de la Vega, L. (2020) High NRF2 levels correlate with poor prognosis in colorectal cancer patients and with sensitivity to the kinase inhibitor AT9283 in vitro. Biomolecules, 10, (doi: 10.3390/biom10101365)

Ivanova, Y., Aitchison, I., Cannon, P., Butler, D., Gadegaard, N., Keith, N. (2020) Mapping of University Research Output and Impact to the United Nations Sustainable Development Goals. (doi: 10.17605/OSF.IO/UFYTA)

Hall, P. E., Shepherd, S. T.C., Brown, J., Larkin, J., Jones, R., Ralph, C., Hawkins, R., Chowdhury, S., Boleti, E., Bahl, A., Fife, K., Webb, A., Crabb, S. J., Geldart, T., Hill, R., Dunlop, J., McLaren, D., Ackerman, C., Wimalasingham, A., Beltran, L., Nathan, P., Powles, T. (2020) Radiological response heterogeneity is of prognostic significance in metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. European Urology Focus, 6, pp. 999-1005. (doi: 10.1016/j.euf.2019.01.010)

Pritchard, J. J.G., Hamilton, G., Hurst, C. D., Fraser, S., Orange, C., Knowles, M. A., Jones, R. J., Leung, H. Y., Iwata, T. (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, 38, pp. 731.e1-737.e10. (doi: 10.1016/j.urolonc.2020.05.012)

Dinneen, E., Haider, A., Freeman, A., Oxley, J., Briggs, T., Nathan, S., Kelly, J., Grierson, J., Allen, C., Persad, R., Aning, J., Oakley, N., Ahmad, I., Dutto, L., Shaw, G. (2020) NeuroSAFE PROOF randomised controlled feasibility study: brief report of perioperative outcomes, histological concordance, and feasibility. European Urology, 78, pp. 476-478. (doi: 10.1016/j.eururo.2020.03.052)

Jones, R., Crabb, S., Chester, J., Elliott, T., Huddart, R., Birtle, A., Evans, L., Lester, J., Jagdev, S., Casbard, A., Huang, C., Madden, T.-A., Griffiths, G. (2020) A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer patients not suitable to receive cisplatin. BJU International, 126, pp. 292-299. (doi: 10.1111/bju.15096)

Golder, A.M., Steele, C.W., Conn, D., Mackay, G.J., McMillan, D.C., Horgan, P.G., Roxburgh, C.S., McSorley, S.T. (2020) Authors' reply: Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections. BJS Open, 4, pp. 730-731. (doi: 10.1002/bjs5.50286)

Richardson, H. E., Cordero, J. B., Grifoni, D. (2020) Basic and translational models of cooperative oncogenesis. International Journal of Molecular Sciences, 21, (doi: 10.3390/ijms21165919)

Park, J. H., Fuglestad, A. J., Køstner, A. H., Oliwa, A., Graham, J., Horgan, P. G., Roxburgh, C. S.D., Kersten, C., McMillan, D. C. (2020) Systemic inflammation and outcome in 2295 patients with stage I-III colorectal cancer from Scotland and Norway: First results from the ScotScan Colorectal Cancer Group. Annals of Surgical Oncology, 27, pp. 2784-2794. (doi: 10.1245/s10434-020-08268-1)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M., Blyth, K., Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14, pp. 1868-1880. (doi: 10.1002/1878-0261.12734)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S., Blyth, K., Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12, (doi: 10.3390/nu12082181)

Lewis, R., Todd, R., Newton, M., Jones, R. J., Wilson, C., Donovan, J. L., Bryan, R. T., Birtle, A., Hall, E. (2020) The implementation and utility of patient screening logs in a multicentre randomised controlled oncology trial. Trials, 21, (doi: 10.1186/s13063-020-04559-w)

Dobbin, S. J.H., Mangion, K., Berry, C., Roditi, G., Basak, S., Sourbron, S., White, J., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, 22, pp. 1276-1277. (doi: 10.1002/ejhf.1847)

Rana, D., Geue, C., Baillie, K., Pan, J., Mueller, T., Laskey, J., Bennie, M., Clarke, J., Jones, R. J., Brown, A., Wu, O. (2020) Healthcare Costs for Metastatic Castration Resistant Prostate Cancer Patients Treated with Abiraterone or Enzalutamide in the Pre and Post Chemotherapy Setting.

Cercek, A. et al. (2020) Mismatch repair-deficient rectal cancer and resistance to neoadjuvant chemotherapy. Clinical Cancer Research, 26, pp. 3271-3279. (doi: 10.1158/1078-0432.CCR-19-3728)

McSorley, S. T., Anderson, J. H., Whittle, T., Roxburgh, C. S., Horgan, P. G., McMillan, D. C., Steele, C. W. (2020) The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer. Perioperative Medicine, 9, (doi: 10.1186/s13741-020-00146-4)

Hanna, C. R., Gatting, L. P., Boyd, K. A., Robb, K. A., Jones, R. J. (2020) Evidencing the impact of cancer trials: insights from the 2014 UK Research Excellence Framework. Trials, 21, (doi: 10.1186/s13063-020-04425-9)

Rooney, N., Mason, S. M., McDonald, L., Däbritz, J. H. M., Campbell, K. J., Hedley, A., Howard, S., Athineos, D., Nixon, C., Clark, W., Leach, J. D., Sansom, O. J., Edwards, J., Cameron, E. R., Blyth, K. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80, pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870)

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., Neidler, S., Rink, C., Karim, S. A., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A. V., Carlin, L. M., Coffelt, S. B., Sansom, O. J., Morton, J. P., Murphy, D. J. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10, pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620)

Quinn, J. A., Bennett, L., Patel, M., Frixou, M., Park, J. H., Roseweir, A., Horgan, P. G., McMillan, D. C., Edwards, J. (2020) The relationship between members of the canonical NF-kB pathway, tumour microenvironment and cancer specific survival in colorectal cancer patients. Histology and Histopathology: Cellular and Molecular Biology, 35, pp. 569-578. (doi: 10.14670/HH-18-168)

Baillie, K., Mueller, T., Pan, J., Laskey, J., Bennie, M., Crearie, C., Kavanagh, K., Alvarez‐Madrazo, S., Morrison, D., Clarke, J., Keel, A., Cameron, D., Wu, O., Kurdi, A., Jones, R. J. (2020) Use of record linkage to evaluate treatment outcomes and trial eligibility in a real‐world metastatic prostate cancer population in Scotland. Pharmacoepidemiology and Drug Safety, 29, pp. 653-663. (doi: 10.1002/pds.4998)

Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107625)

ALHAYYAN, A., McSorley, S. T., Kearns, R. J., Horgan, P. G., Roxburgh, C. S.D., McMillan, D. C. (2020) The relationship between anaesthetic technique, clinicopathological characteristics and the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colon cancer. PLoS ONE, 15, (doi: 10.1371/journal.pone.0228580)

Bellec, K., Cordero, J. B. (2020) The peroxisome: a new player in intestinal epithelial repair. Developmental Cell, 53, pp. 131-132. (doi: 10.1016/j.devcel.2020.03.023)

Fulton, B., Jones, R., Powles, T., Crabb, S., Paul, J., Birtle, A., Chowdhury, S., Hussain, S., Morris, A., Soulis, E., Morrison, P. (2020) ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screening trial of maintenance targeted therapy after chemotherapy in patients with advanced or metastatic urothelial cancer. Trials, 21, (doi: 10.1186/s13063-020-04283-5)

Birtle, A., Johnson, M., Chester, J., Jones, R., Dolling, D., Bryan, R. T., Harris, C., Winterbottom, A., Blacker, A., Catto, J. W.F., Chakraborti, P., Donovan, J. L., Elliott, P. A., French, A., Jagdev, S., Jenkins, B., Keeley, F. X., Kockelbergh, R., Powles, T., Wagstaff, J., Wilson, C., Todd, R., Lewis, R., Hall, E. (2020) Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial. Lancet, 395, pp. 1268-1277. (doi: 10.1016/S0140-6736(20)30415-3)

Michalopoulou, E., Auciello, F. R., Bulusu, V., Strachan, D., Campbell, A. D., Tait-Mulder, J., Karim, S. A., Morton, J. P., Sansom, O. J., Kamphorst, J. J. (2020) Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition. Cell Reports, 30, pp. 2729-2742.e4. (doi: 10.1016/j.celrep.2020.01.080)

Patel, R., Brzezinska, E. A., Repiscak, P., Ahmad, I., Mui, E., Gao, M., Blomme, A., Harle, V., Tan, E. H., Malviya, G., Mrowinska, A., Loveridge, C. J., Rushworth, L. K., Edwards, J., Ntala, C., Nixon, C., Hedley, A., Mackay, G., Tardito, S., Sansom, O. J., Leung, H. Y. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80, pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684)

Witjes, J. A. et al. (2020) EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multistakeholder effort† EU*ACME: under the auspices of the EAU-ESMO guidelines committees. European Urology, 77, pp. 223-250. (doi: 10.1016/j.eururo.2019.09.035)

Mohan, S., Foy, V., Ayub, M., Leong, H. S., Schofield, P., Sahoo, S., Descamps, T., Kilerci, B., Smith, N. K., Carter, M., Priest, L., Zhou, C., Carr, T. H., Miller, C., Faivre-Finn, C., Blackhall, F., Rothwell, D. G., Dive, C., Brady, G. (2020) Profiling of circulating free DNA using targeted and genome-wide sequencing in patients with SCLC. Journal of Thoracic Oncology, 15, pp. 216-230. (doi: 10.1016/j.jtho.2019.10.007)

Kennedy, S. A. et al. (2020) Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nature Communications, 11, (doi: 10.1038/s41467-019-14224-9)

Wilson, D. H., Jarman, E. J., Mellin, R. P., Wilson, M. L., Waddell, S. H., Tsokkou, P., Younger, N. T., Raven, A., Bhalla, S. R., Noll, A. T. R., Olde Damink, S. W., Schaap, F. G., Chen, P., Bates, D. O., Banales, J. M., Dean, C. H., Henderson, D. J., Sansom, O. J., Kendall, T. J., Boulter, L. (2020) Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nature Communications, 11, (doi: 10.1038/s41467-020-14283-3)

Maniati, E., Berlato, C., Gopinathan, G., Heath, O., Kotantaki, P., Lakhani, A., McDermott, J., Pegrum, C., Delaine-Smith, R. M., Pearce, O. M.T., Hirani, P., Joy, J. D., Szabova, L., Perets, R., Sansom, O. J., Drapkin, R., Bailey, P., Balkwill, F. R. (2020) Mouse ovarian cancer models recapitulate the human tumor microenvironment and patient response to treatment. Cell Reports, 30, pp. 525-540.e7. (doi: 10.1016/j.celrep.2019.12.034)

Mateo, J. et al. (2020) Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncology, 21, pp. 162-174. (doi: 10.1016/S1470-2045(19)30684-9)

Dreyer, S.B., Jamieson, N.B., Morton, J.P., Sansom, O.J., Biankin, A.V., Chang, D.K. (2020) Pancreatic cancer: from genome discovery to PRECISION-Panc. Clinical Oncology, 32, pp. 5-8. (doi: 10.1016/j.clon.2019.08.007)

Chapman, S.J. et al. (2020) Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery. British Journal of Surgery, 107, pp. e161-e169. (doi: 10.1002/bjs.11326)

McGregor, G. H., Campbell, A. D., Fey, S. K., Tumanov, S., Sumpton, D., Rodriguez Blanco, G., Mackay, G., Nixon, C., Vazquez, A., Sansom, O. J., Kamphorst, J. J. (2020) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, 80, pp. 175-188. (doi: 10.1158/0008-5472.CAN-19-0644)

Alhayyan, A., McSorley, S., Roxburgh, C., Kearns, R., Horgan, P., McMillan, D. (2020) The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: a systematic review and meta-analysis. Surgery Open Science, 2, pp. 1-21. (doi: 10.1016/j.sopen.2019.06.001)

Knight, K.A., Horgan, P.G., McMillan, D.C., Roxburgh, C.S.D., Park, J.H. (2020) The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: a systematic review. International Journal of Surgery, 73, pp. 42-49. (doi: 10.1016/j.ijsu.2019.11.023)

Loveridge, C. J., Slater, S., Campbell, K. J., Nam, N. A., Knight, J., Ahmad, I., Hedley, A., Lilla, S., Repiscak, P., Patel, R., Salji, M., Fleming, J., Mitchell, L., Nixon, C., Strathdee, D., Neilson, M., Ntala, C., Bryson, S., Zanivan, S. R., Edwards, J., Robson, C. N., Goodyear, C. S., Blyth, K., Leung, H. Y. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x)

McSorley, S. T., Tham, A., Dolan, R. D., Steele, C. W., Ramsingh, J., Roxburgh, C., Horgan, P. G., McMillan, D. C. (2020) Perioperative blood transfusion is associated with the postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Annals of Surgical Oncology, 27, pp. 833-843. (doi: 10.1245/s10434-019-07984-7)

Clark, E., Morton, M., Sharma, S., Fisher, H., Howel, D., Walker, J., Wood, R., Hancock, H., Maier, R., Marshall, J., Bahl, A., Crabb, S., Jain, S., Pedley, I., Jones, R., Staffurth, J., Heer, R. (2019) Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol. BMJ Open, 9, (doi: 10.1136/bmjopen-2019-034708)

Paterson, C., Thomson, M., Caldwell, B., Young, R., McLean, A., Porteous, S., Clark, S., Messow, C. M., Kean, S., Grose, D., Lamb, C., Rizwannullah, M., James, A., Schipani, S., Wilson, C., Rulach, R., Jones, R. (2019) Radiotherapy-induced xerostomia: a randomised, double-blind, controlled trial of Visco-ease™ oral spray compared with placebo in patients with cancer of the head and neck. British Journal of Oral and Maxillofacial Surgery, 57, pp. 1119-1125. (doi: 10.1016/j.bjoms.2019.10.300)

Hoyle, A. P. et al. (2019) Abiraterone in "high-" and "low-risk" metastatic hormone-sensitive prostate cancer. European Urology, 76, pp. 719-728. (doi: 10.1016/j.eururo.2019.08.006)

Clarke, N. W. et al. (2019) Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial. Annals of Oncology, 30, pp. 1992-2003. (doi: 10.1093/annonc/mdz396)

Golder, A. M., McSorley, S. T., Kearns, R. J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. (2019) Attitudes towards the use of perioperative steroids in resectional colorectal cancer surgery in the UK: a qualitative study. Annals of Medicine and Surgery, 48, pp. 23-28. (doi: 10.1016/j.amsu.2019.10.007)

Liko, D., Mitchell, L., Campbell, K., Ridgway, R., Jones, C., Dudek, K., King, A., Bryson, S., Stevenson, D., Blyth, K., Strathdee, D., Morton, J. P., Bird, T., Knight, J. R.P., Willis, A. E., Sansom, O. J. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26, pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7)

Golder, A.M., Steele, C.W., Conn, D., Mackay, G.J., McMillan, D.C., Horgan, P.G., Roxburgh, C.S., McSorley, S.T. (2019) Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections. BJS Open, 3, pp. 830-839. (doi: 10.1002/bjs5.50224)

Almasaudi, A. S., McSorley, S. T., Dolan, R. D., Edwards, C. A., McMillan, D. C. (2019) The relation between Malnutrition Universal Screening Tool (MUST), computed tomography-derived body composition, systemic inflammation, and clinical outcomes in patients undergoing surgery for colorectal cancer. American Journal of Clinical Nutrition, 110, pp. 1327-1334. (doi: 10.1093/ajcn/nqz230)

Horwich, A. et al. (2019) EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees. Annals of Oncology, 30, pp. 1697-1727. (doi: 10.1093/annonc/mdz296)

Malik, N., Dunn, K. M., Cassels, J., Hay, J., Estell, C., Sansom, O. J., Michie, A. M. (2019) mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Scientific Reports, 9, (doi: 10.1038/s41598-019-53141-1)

Schmidt, S. et al. (2019) A MYC/GCN2/eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature Cell Biology, 21, pp. 1413-1424. (doi: 10.1038/s41556-019-0408-0)

Joharatnam-Hogan, N. et al. (2019) Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. Lancet Gastroenterology and Hepatology, 4, pp. 854-862. (doi: 10.1016/S2468-1253(19)30289-4)

Hasan, M. N., Rouprêt, M., Keeley, F., Cracco, C., Jones, R., Straub, M., Traxer, O., Osther, P. J. S., Brehmer, M. (2019) Consultation on UTUC, Stockholm 2018 aspects of risk stratification: long-term results and follow-up. World Journal of Urology, 37, pp. 2289-2296. (doi: 10.1007/s00345-019-02739-1)

Jung, H., Giusti, G., Fajkovic, H., Herrmann, T., Jones, R., Straub, M., Baard, J., Osther, P. J. S., Brehmer, M. (2019) Consultation on UTUC, Stockholm 2018: aspects of treatment. World Journal of Urology, 37, pp. 2279-2287. (doi: 10.1007/s00345-019-02811-w)

Almasaudi, A. S., Dolan, R. D., McSorley, S. T., Horgan, P. G., Edwards, C., McMillan, D. C. (2019) Relationship between computed tomography-derived body composition, sex, and post-operative complications in patients with colorectal cancer. European Journal of Clinical Nutrition, 73, pp. 1450-1457. (doi: 10.1038/s41430-019-0414-0)

Roxburgh, C.S.D., Strombom, P., Lynn, P., Cercek, A., Gonen, M., Smith, J., Temple, L.K.F., Nash, G.M., Guillem, J.G., Paty, P.B., Shia, J., Vakiani, E., Yaeger, R., Stadler, Z.K., Segal, N.H., Reidy, D., Varghese, A., Wu, A.J., Crane, C.H., Gollub, M.J., Saltz, L.B., Garcia‐Aguilar, J., Weiser, M.R. (2019) Changes in the multidisciplinary management of rectal cancer from 2009 to 2015 and associated improvements in short‐term outcomes. Colorectal Disease, 21, pp. 1140-1150. (doi: 10.1111/codi.14713)

Kroon, H. M. et al. (2019) Palliative pelvic exenteration: A systematic review of patient-centered outcomes. European Journal of Surgical Oncology, 45, pp. 1787-1795. (doi: 10.1016/j.ejso.2019.06.011)

Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25, pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36, pp. 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003)

Park, J. H., van Wyk, H., McMillan, D. C., Edwards, J., Orange, C., Horgan, P. G., Roxburgh, C. S.D. (2019) Pre-operative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer. Journal of Pathology: Clinical Research, 6, pp. 30-39. (doi: 10.1002/cjp2.143)

McSorley, S. T., Dolan, R. D., Roxburgh, C. S.D., Horgan, P. G., MacKay, G. J., McMillan, D. C. (2019) Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer. European Journal of Surgical Oncology, 45, pp. 1613-1618. (doi: 10.1016/j.ejso.2019.05.020)

Bilsland, A. E., Liu, Y., Turnbull, A., Sumpton, D., Stevenson, K., Cairney, C. J., Boyd, S. M., Roffey, J., Jenkinson, D., Keith, W. N. (2019) A novel pyrazolopyrimidine ligand of human PGK1 and stress sensor DJ1 modulates the shelterin complex and telomere length regulation. Neoplasia, 21, pp. 893-907. (doi: 10.1016/j.neo.2019.07.008)

Wellenstein, M. D., Coffelt, S. B., Duits, D. E.M., van Miltenburg, M. H., Slagter, M., de Rink, I., Henneman, L., Kas, S. M., Prekovic, S., Hau, C.-S., Vrijland, K., Drenth, A. P., de Korte-Grimmerink, R., Schut, E., van der Heijden, I., Zwart, W., Wessels, L. F.A., Schumacher, T. N.M., Jonkers, J., de Visser, K. E. (2019) Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis. Nature, 572, pp. 538-542. (doi: 10.1038/s41586-019-1450-6)

Mackey, J. B.G., Coffelt, S. B., Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, (doi: 10.3389/fimmu.2019.01912)

Vennin, C. et al. (2019) CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, (doi: 10.1038/s41467-019-10968-6)

Attard, G., Merseburger, A. S., Arlt, W., Sternberg, C. N., Feyerabend, S., Berruti, A., Joniau, S., Géczi, L., Lefresne, F., Lahaye, M., Shelby, F. N., Pissart, G., Chua, S., Jones, R. J., Tombal, B. (2019) Assessment of the safety of glucocorticoid regimens in combination with abiraterone acetate formetastatic castration-resistant prostate Cancer: a randomized, open-label phase 2 study. JAMA Oncology, 5, pp. 1159-1167. (doi: 10.1001/jamaoncol.2019.1011)

Andisha, N. M., McMillan, D. C., Gujam, F. J.A., Roseweir, A., Edwards, J. (2019) The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer. Cellular Signalling, 60, pp. 91-99. (doi: 10.1016/j.cellsig.2019.04.006)

Reader, C. S., Vallath, S., Steele, C. W., Haider, S., Brentnall, A., Desai, A., Moore, K. M., Jamieson, N. B., Chang, D., Bailey, P., Scarpa, A., Lawlor, R., Chelala, C., Keyse, S. M., Biankin, A., Morton, J. P., Evans, T.R. J., Barry, S. T., Sansom, O. J., Kocher, H. M., Marshall, J. F. (2019) The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology, 249, pp. 332-342. (doi: 10.1002/path.5320)

McSorley, S. T., Tham, A., Steele, C. W., Dolan, R. D., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2019) Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. European Journal of Surgical Oncology, 45, pp. 1205-1211. (doi: 10.1016/j.ejso.2019.02.027)

Parvy, J.-P., Yu, Y., Dostalova, A., Kondo, S., Kurjan, A., Bulet, P., Lemaitre, B., Vidal, M., Cordero, J. B. (2019) The antimicrobial peptide Defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila. eLife, 8, (doi: 10.7554/eLife.45061)

Silva-Santos, B., Mensurado, S., Coffelt, S. B. (2019) γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer, 19, pp. 392-404. (doi: 10.1038/s41568-019-0153-5)

Alyamani, A.M.A., Quinn, J.A., Greenhalgh, D.A. (2019) Activated β-catenin Expression Inhibits Papillomas in HK1.ras Transgenic Mice Via Increased p53/p21-Associated Differentiation. (doi: 10.1111/bjd.17776)

McMenemy, C., Quinn, J.A., Greenhalgh, D.A. (2019) Epidermal-Specific 14-3-3σ/Stratifin Overexpressioninduces Malignant Conversion of Aggressive, Rapid-growth Papillomas, but not Slower, Regression-prone Papillomas. (doi: 10.1111/bjd.17776)

Leach, J., Morton, J. P., Sansom, O. J. (2019) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, 110, pp. 69-76. (doi: 10.1016/j.molimm.2017.12.013)

Khongthong, P., Roseweir, A. K., Edwards, J. (2019) The NF-KB pathway and endocrine therapy resistance in breast cancer. Endocrine-Related Cancer, 26, pp. R369-R380. (doi: 10.1530/ERC-19-0087)

Bangi, E. et al. (2019) A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer. Science Advances, 5, (doi: 10.1126/sciadv.aav6528)

Memon, D., Bi, J., Miller, C. J. (2019) In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. Scientific Reports, 9, (doi: 10.1038/s41598-019-43758-7)

Roseweir, A. K., Clark, J., McSorley, S. T., vanWyk, H. C., Quinn, J. A., Horgan, P. G., McMillan, D. C., Park, J. H., Edwards, J. (2019) The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer. International Journal of Cancer, 144, pp. 2320-2329. (doi: 10.1002/ijc.32045)

McSorley, S. T., Tham, A., Jones, I., Talwar, D., McMillan, D. C. (2019) Regression correction equation to adjust serum iron and ferritin concentrations based on C-reactive protein and albumin in patients receiving primary and secondary care. Journal of Nutrition, 149, pp. 877-883. (doi: 10.1093/jn/nxz008)

Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25, pp. 738-743. (doi: 10.1038/s41591-019-0380-z)

Mac Gabhann, F., Ung, P. M. U., Sonoshita, M., Scopton, A. P., Dar, A. C., Cagan, R. L., Schlessinger, A. (2019) Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network. PLoS Computational Biology, 15, (doi: 10.1371/journal.pcbi.1006878)

Salvucci, M., Rahman, A., Resler, A. J., Udupi, G. M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Longley, D. B., Johnston, P. G., Lawler, M., Wilson, R., Salto-Tellez, M., Van Schaeybroeck, S., Rafferty, M., Gallagher, W. M., Rehm, M., Prehn, J. H.M. (2019) A machine learning platform to optimize the translation of personalized network models to the clinic. JCO Clinical Cancer Informatics, pp. 1-17. (doi: 10.1200/CCI.18.00056)

Neves, K. B., Rios, F. J., Jones, R., Evans, T. R. J., Montezano, A. C., Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115, pp. 978-988. (doi: 10.1093/cvr/cvz021)

Smith, J. J. et al. (2019) Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy. JAMA Oncology, 5, (doi: 10.1001/jamaoncol.2018.5896)

Roxburgh, C. S.D., Strombom, P., Lynn, P., Gonen, M., Paty, P. B., Guillem, J. G., Nash, G. M., Smith, J. J., Wei, I., Pappou, E., Garcia-Aguilar, J., Weiser, M. R. (2019) Role of the interval from completion of neoadjuvant therapy to surgery in postoperative morbidity in patients with locally advanced rectal cancer. Annals of Surgical Oncology, 26, pp. 2019-2027. (doi: 10.1245/s10434-019-07340-9)

Johansson, J., Naszai, M., Hodder, M. C., Pickering, K. A., Miller, B. W., Ridgway, R. A., Yu, Y., Peschard, P., Brachmann, S., Campbell, A. D., Cordero, J. B., Sansom, O. J. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, 24, pp. 592-607.E7. (doi: 10.1016/j.stem.2019.02.002)

Dolan, R. D., McLees, N. G., Irfan, A., McSorley, S. T., Horgan, P. G., Colville, D., McMillan, D. C. (2019) The relationship between tumour glucose metabolism and host systemic inflammatory responses in patients with cancer: a systematic review. Journal of Nuclear Medicine, 60, pp. 467-471. (doi: 10.2967/jnumed.118.216697)

McAllister, M. J., Underwood, M. A., Leung, H. Y., Edwards, J. (2019) A review on the interactions between the tumour microenvironment and androgen receptor signaling in prostate cancer. Translational Research, 206, pp. 91-106. (doi: 10.1016/j.trsl.2018.11.004)

Roseweir, A. K., Powell, A. G.M.T., Horstman, S. L., Inthagard, J., Park, J. A., McMillan, D. C., Horgan, P. G., Edwards, J. (2019) Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer. Cellular Signalling, 56, pp. 15-22. (doi: 10.1016/j.cellsig.2019.01.007)

Almasaudi, A. S., McSorley, S. T., Horgan, P. G., McMillan, D. C., Edwards, C. A. (2019) The relationship between body mass index, sex, and postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer. Clinical Nutrition ESPEN, 30, pp. 185-189. (doi: 10.1016/j.clnesp.2018.12.084)

Salvagno, C., Ciampricotti, M., Tuit, S., Hau, C.-S., van Weverwijk, A., Coffelt, S. B., Kersten, K., Vrijland, K., Kos, K., Ulas, T., Song, J.-Y., Ooi, C.-H., Rüttinger, D., Cassier, P. A., Jonkers, J., Schultze, J. L., Ries, C. H., de Visser, K. E. (2019) Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology, 21, pp. 511-521. (doi: 10.1038/s41556-019-0298-1)

Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., Evans, J., Hall, J. A., Kinrade, S., Jones, D., Jones, P. S., Jones, R., Marshall, J. F., Panico, M. B., Shaw, J. A., Steeg, P. S., Sullivan, M., Tong, W., Westwell, A. D., Ritchie, J. W.A. (2019) A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology, 16, pp. 185-204. (doi: 10.1038/s41571-018-0134-8)

Cosimo, E., Tarafdar, A., Moles, M. W., Holroyd, A. K., Malik, N., Catherwood, M. A., Hay, J., Dunn, K. M., Macdonald, A. M., Guichard, S. M., O'Rourke, D. M., Leach, M. T., Sansom, O. J., Cosulich, S. C., McCaig, A. M., Michie, A. M. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25, pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036)

McSorley, S., Johnstone, M., Steele, C. W., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C., Mansouri, D. (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. International Journal of Colorectal Disease, 34, pp. 401-408. (doi: 10.1007/s00384-018-3211-7)

Gay, D. M., Ridgway, R. A., Müeller, M., Hodder, M. C., Hedley, A., Clark, W., Leach, J. D., Jackstadt, R., Nixon, C., Huels, D. J., Campbell, A. D., Bird, T. G., Sansom, O. J. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, (doi: 10.1038/s41467-019-08586-3)

Scopelliti, A., Bauer, C., Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J., Vidal, M., Maddocks, O. D.K., Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29, pp. 269-284.e10. (doi: 10.1016/j.cmet.2018.09.021)

Kugeratski, F. G., Atkinson, S. J., Neilson, L. J., Lilla, S., Knight, J. R.P., Serneels, J., Juin, A., Ismail, S., Bryant, D. M., Markert, E. K., Machesky, L. M., Mazzone, M., Sansom, O. J., Zanivan, S. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12, (doi: 10.1126/scisignal.aan8247)

McCormick, P. N., Greenwood, H. E., Glaser, M., Maddocks, O. D.K., Gendron, T., Sander, K., Gowrishankar, G., Hoehne, A., Zhang, T., Shuhendler, A. J., Lewis, D. Y., Berndt, M., Koglin, N., Lythgoe, M. F., Gambhir, S. S., Årstad, E., Witney, T. H. (2019) Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity. Cancer Research, 79, pp. 853-863. (doi: 10.1158/0008-5472.CAN-18-2634)

Parry, M. A., Srivastava, S., Ali, A., Cannistraci, A., Antonello, J., Barros-Silva, J. D., Ubertini, V., Ramani, V., Lau, M., Shanks, J., Nonaka, D., Oliveira, P., Hambrock, T., Leong, H. S., Dhomen, N., Miller, C., Brady, G., Dive, C., Clarke, N. W., Marais, R., Baena, E. (2019) Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer. European Urology Oncology, 2, pp. 1-11. (doi: 10.1016/j.euo.2018.08.005)

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L. S., Sansom, O. J., Barry, S. T., Inman, G. I. (2019) Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor β superfamily type 1 receptors. Molecular Pharmacology, 95, pp. 222-234. (doi: 10.1124/mol.118.112946)

Pennel, K. A.F., Park, J. H., McMillan, D. C., Roseweir, A. K., Edwards, J. (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013)

Dolan, R., Almasaudi, A. S., Dieu, L. B., Horgan, P. G., McSorley, S. T., McMillan, D. C. (2019) The relationship between computed tomography‐derived body composition, systemic inflammatory response, and survival in patients undergoing surgery for colorectal cancer. Journal of Cachexia, Sarcopenia and Muscle, 10, pp. 111-122. (doi: 10.1002/jcsm.12357)

Lallo, A., Gulati, S., Schenk, M. W., Khandelwal, G., Berglund, U. W., Pateras, I. S., Chester, C. P. E., Pham, T. M., Kalderen, C., Frese, K. K., Gorgoulis, V. G., Miller, C., Blackhall, F., Helleday, T., Dive, C. (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176, pp. 436-450. (doi: 10.1111/bph.14542)

Roseweir, A.K., Kong, C.Y., Park, J.H., Bennett, L., Powell, A.G.M.T., Quinn, J., van Wyk, H.C., Horgan, P.G., McMillan, D.C., Edwards, J., Roxburgh, C.S. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144, pp. 150-159. (doi: 10.1002/ijc.31739)

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C. D., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G., Sears, R. C. (2019) Activation of PP2A and Inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma. Cancer Research, 79, pp. 209-219. (doi: 10.1158/0008-5472.CAN-18-0717)

Inthagard, J., Edwards, J., Roseweir, A. K. (2019) Immunotherapy: enhancement the efficacy of this promising therapeutic in multiple cancers. Clinical Science, 133, pp. 181-193. (doi: 10.1042/CS20181003)

Morrow, E., Roseweir, A., Edwards, J. (2019) The role of gamma delta T lymphocytes in breast cancer: a review. Translational Research, 203, pp. 88-96. (doi: 10.1016/j.trsl.2018.08.005)

Menon, M., Elliott, R., Bowers, L., Balan, N., Rafiq, R., Costa-Cabral, S., Munkonge, F., Trinidade, I., Porter, R., Campbell, A. D., Johnson, E. R., Esdar, C., Buchstaller, H.-P., Leuthner, B., Rohdich, F., Schneider, R., Sansom, O., Wienke, D., Ashworth, A., Lord, C. J. (2019) A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific Reports, 9, (doi: 10.1038/s41598-018-36447-4)

Clyde, M., McAllister, J., Obeidallah, A., Ahmad, I. (2019) Actinomyces odontolyticus infection 3 months post-robotic-assisted laparoscopic prostatectomy. BMJ Case Reports, 12, (doi: 10.1136/bcr-2018-228184)

Witney, T. H., Lewis, D. Y. (2019) Imaging cancer metabolism with Positron Emission Tomography (PET) Springer

Rohwer, N. et al. (2019) Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene, 38, pp. 5670-5685. (doi: 10.1038/s41388-019-0816-4)

Van Wyk, H., Roseweir, A., Alexander, P., Park, J. H., Horgan, P., McMillan, D., Edwards, J. (2019) The relationship between tumour budding, tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Surgical Oncology, 26, pp. 4397-4404. (doi: 10.1245/s10434-019-07931-6)

Kim, C. S., Mohan, S., Ayub, M., Rothwell, D. G., Dive, C., Brady, G., Miller, C. (2018) In silico error correction improves cfDNA mutation calling. Bioinformatics, 35, pp. 2380-2385. (doi: 10.1093/bioinformatics/bty1004)

Woods, B. S. et al. (2018) Addition of docetaxel to first-line long-term hormone therapy in prostate cancer (STAMPEDE): modelling to estimate long-term survival, quality-adjusted survival, and cost-effectiveness. European Urology Oncology, 1, pp. 449-458. (doi: 10.1016/j.euo.2018.06.004)

Hussain, S. A., Birtle, A., Crabb, S., Huddart, R., Small, D., Summerhayes, M., Jones, R., Protheroe, A. (2018) From clinical trials to real-life clinical practice: the role of immunotherapy with PD-1/PD-L1 inhibitors in advanced urothelial carcinoma. European Urology Oncology, 1, pp. 486-500. (doi: 10.1016/j.euo.2018.05.011)

Salji, M., Hendry, J., Patel, A., Ahmad, I., Nixon, C., Leung, H. Y. (2018) Peri-prostatic fat volume measurement as a predictive tool for castration resistance in advanced prostate cancer. European Urology Focus, 4, pp. 858-866. (doi: 10.1016/j.euf.2017.01.019)

Parker, C. C. et al. (2018) Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet, 392, pp. 2353-2366. (doi: 10.1016/S0140-6736(18)32486-3)

Roxburgh, C. S., Weiser, M. R. (2018) Selective use of radiation for locally advanced rectal cancer: one size does not fit all. Minerva Chirurgica, 73, pp. 592-600. (doi: 10.23736/S0026-4733.18.07791-X)

Chou, A. et al. (2018) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut, 67, pp. 2142-2155. (doi: 10.1136/gutjnl-2017-315144)

Dobbin, S. J.H., Cameron, A. C., Petrie, M. C., Jones, R. J., Touyz, R. M., Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104, pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726)

Román-Fernández, Á., Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E., Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, (doi: 10.1038/s41467-018-07464-8)

Roxburgh, C. S., Fenig, Y. M., Cercek, A., Shia, J., Rassam, R. M., Paty, P. B., Nash, G. M. (2018) Outcomes of low-grade appendiceal mucinous neoplasms with remote acellular mucinous peritoneal deposits. Annals of Surgical Oncology, 26, pp. 118-124. (doi: 10.1245/s10434-018-7003-7)

Greenhough, A., Bagley, C., Heesom, K. J., Gurevich, D. B., Gay, D., Bond, M., Collard, T. J., Paraskeva, C., Martin, P., Sansom, O. J., Malik, K., Williams, A. C. (2018) Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis. EMBO Molecular Medicine, 10, (doi: 10.15252/emmm.201708699)

Arkenau, H.-T., Italiano, A., Mak, G., Toulmonde, M., Baird, R.D., Garcia-Corbacho, J., Plummer, R., Flynn, M., Forster, M., Wilson, R.H., Tosi, D., Adenis, A., Donaldson, K., Posner, J., Kawabata, I., Arimura, A., Deva, S., Spicer, J. (2018) An extended phase Ib study of epertinib, an orally active reversible dual EGFR/HER2 tyrosine kinase inhibitor, in patients with solid tumours. European Journal of Cancer, 103, pp. 17-23. (doi: 10.1016/j.ejca.2018.07.134)

Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J., Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, 246, pp. 331-343. (doi: 10.1002/path.5143)

Hewit, K., Sandilands, E., Sanchez Martinez, R., James, D., Leung, H. Y., Bryant, D. M., Shanks, E., Markert, E. K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-1115-7)

Malik, N., Sansom, O. J., Michie, A. M. (2018) The role of mTOR-mediated signals during haemopoiesis and lineage commitment. Biochemical Society Transactions, 46, pp. 1313-1324. (doi: 10.1042/BST20180141)

Mulholland, T., McAllister, M., Patek, S., Flint, D., Underwood, M., Sim, A., Edwards, J., Zagnoni, M. (2018) Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient. Scientific Reports, 8, (doi: 10.1038/s41598-018-33055-0)

Roseweir, A. K., McMillan, D. C., Edwards, J. (2018) Reply to comment of "ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer" British Journal of Cancer, 119, pp. 909. (doi: 10.1038/s41416-018-0275-7)

Smit, S., Kwakkel, J., Keith, N. (2018) Accomplissh: creating societal impact from social sciences and humanities research. European Commission

Fort, L., Batista, J. M., Thomason, P. A., Spence, H. J., Whitelaw, J., Tweedy, L., Greaves, J., Martin, K. J., Anderson, K. I., Brown, P., Lilla, S., Neilson, M. P., Tafelmeyer, P., Zanivan, S., Ismail, S., Bryant, D. M., Tomkinson, N. C.O., Chamberlain, L. H., Mastick, G. S., Insall, R. H., Machesky, L. M. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20, pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9)

Paul, A., Edwards, J., Pepper, C., Mackay, S. (2018) Inhibitory-κB kinase (IKK) α and nuclear factor-κB (NFκB)-inducing kinase (NIK) as anti-cancer drug targets. Cells, 7, (doi: 10.3390/cells7100176)

Flanagan, D.J., Hodder, M.C., Sansom, O.J. (2018) Microenvironmental cues in cancer stemness. Nature Cell Biology, 20, pp. 1102-1104. (doi: 10.1038/s41556-018-0210-4)

Lallo, A., Frese, K. K., Morrow, C. J., Sloane, R., Gulati, S., Schenk, M. W., Trapani, F., Simms, N., Galvin, M., Brown, S., Hodgkinson, C. L., Priest, L., Hughes, A., Lai, Z., Cadogan, E., Khandelwal, G., Simpson, K. L., Miller, C., Blackhall, F., O'Connor, M. J., Dive, C. (2018) The combination of the PARP inhibitor Olaparib and the WEE1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer. Clinical Cancer Research, 24, pp. 5153-5164. (doi: 10.1158/1078-0432.CCR-17-2805)

Park, J. H., Ishizuka, M., McSorley, S. T., Kubota, K., Roxburgh, C. S.D., Nagata, H., Takagi, K., Iwasaki, Y., Aoki, T., Horgan, P. G., McMillan, D. C. (2018) Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer. American Journal of Surgery, 216, pp. 458-464. (doi: 10.1016/j.amjsurg.2017.08.044)

Basu, B. et al. (2018) Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of Oncology, 29, pp. 1918-1925. (doi: 10.1093/annonc/mdy245)

Cross, W. et al. (2018) The evolutionary landscape of colorectal tumorigenesis. Nature Ecology and Evolution, 2, pp. 1661-1672. (doi: 10.1038/s41559-018-0642-z)

Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aan1230)

Stehbens, S. J., Ju, R. J., Adams, M. N., Perry, S., Haass, N. K., Bryant, D. M., Pollock, P. M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, (doi: 10.1242/jcs.213678)

McSorley, S.T., Steele, C.W., McMahon, A.J. (2018) Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery. BJS Open, 2, pp. 185-194. (doi: 10.1002/bjs5.68)

Das, T. K., Esernio, J., Cagan, R. L. (2018) Restraining network response to targeted cancer therapies improves efficacy and reduces cellular resistance. Cancer Research, 78, pp. 4344-4359. (doi: 10.1158/0008-5472.CAN-17-2001)

Lua, J., Qayyum, T., Edwards, J., Roseweir, A. K. (2018) The prognostic role of the non-canonical nuclear factor-kappa B pathway in renal cell carcinoma patients. Urologia Internationalis, 101, pp. 190-196. (doi: 10.1159/000489816)

McSorley, S. T., Black, D. H., Horgan, P. G., McMillan, D. C. (2018) The relationship between tumour stage, systemic inflammation, body composition and survival in patients with colorectal cancer. Clinical Nutrition, 37, pp. 1279-1285. (doi: 10.1016/j.clnu.2017.05.017)

Gujam, F., Dickson, K., McCall, P., McMillan, D., Edwards, J. (2018) The relationship between androgen receptor, components of tumour microenvironment and survival in breast cancer molecular subtypes. Cancer Therapy and Oncology, 11,

Roseweir, A. K., Halcrow, E. S., Chichilo, S., Powell, A. G.M.T., McMillan, D. C., Horgan, P. G., Edwards, J. (2018) ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer. British Journal of Cancer, 119, pp. 323-329. (doi: 10.1038/s41416-018-0174-y)

Dolan, R. D., McSorley, S. T., Park, J. H., Watt, D. G., Roxburgh, C. S., Horgan, P. G., McMillan, D. C. (2018) The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. British Journal of Cancer, 119, pp. 40-51. (doi: 10.1038/s41416-018-0095-9)

McSorley, S. T., Talwar, D., McMillan, D. C. (2018) Comment on the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. American Journal of Clinical Nutrition, 108, pp. 204-205. (doi: 10.1093/ajcn/nqx071)

Morris, H. T., Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H., Snapper, S. B., Carey, F. A., Sansom, O. J., Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, 245, pp. 337-348. (doi: 10.1002/path.5086)

May, S., Owen, H., Phesse, T. J., Greenow, K. R., Jones, G.-R., Blackwood, A., Cook, P. C., Towers, C., Gallimore, A. M., Williams, G. T., Stürzl, M., Britzen-Laurent, N., Sansom, O. J., MacDonald, A. S., Bird, A. P., Clarke, A. R., Parry, L. (2018) Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology, 245, pp. 270-282. (doi: 10.1002/path.5074)

Patel, M., Horgan, P. G., McMillan, D. C., Edwards, J. (2018) NF-κB pathways in the development and progression of colorectal cancer. Translational Research, 197, pp. 43-56. (doi: 10.1016/j.trsl.2018.02.002)

Torres-Ayuso, P., Sahoo, S., Ashton, G., An, E., Simms, N., Galvin, M., Leong, H. S., Frese, K. K., Simpson, K., Cook, N., Hughes, A., Miller, C. J., Marais, R., Dive, C., Krebs, M. G., Brognard, J. (2018) Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin. npj Genomic Medicine, 3, (doi: 10.1038/s41525-018-0055-6)

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P., Murphy, D. J. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aao2565)

McSorley, S. T., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2018) The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer. Perioperative Medicine, 7, (doi: 10.1186/s13741-018-0093-8)

Cercek, A., Roxburgh, C. S.D., Strombom, P., Smith, J. J., Temple, L. K.F., Nash, G. M., Guillem, J. G., Paty, P. B., Yaeger, R., Stadler, Z. K., Seier, K., Gonen, M., Segal, N. H., Reidy, D. L., Varghese, A., Shia, J., Vakiani, E., Wu, A. J., Crane, C. H., Gollub, M. J., Garcia-Aguilar, J., Saltz, L. B., Weiser, M. R. (2018) Adoption of total neoadjuvant therapy for locally advanced rectal cancer. JAMA Oncology, 4, (doi: 10.1001/jamaoncol.2018.0071)

Conway, J. R.W. et al. (2018) Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer. Cell Reports, 23, pp. 3312-3326. (doi: 10.1016/j.celrep.2018.05.038)

Hodder, M. C., Flanagan, D. J., Sansom, O. J. (2018) Intestinal stem cell dynamics: a story of mice and humans. Cell Stem Cell, 22, pp. 785-787. (doi: 10.1016/j.stem.2018.05.005)

Allen, W. L. et al. (2018) Transcriptional subtyping and CD8 immunohistochemistry identifies patients with stage II and III colorectal cancer with poor prognosis who benefit from adjuvant chemotherapy. JCO Precision Oncology, pp. 1-15. (doi: 10.1200/PO.17.00241)

Pearson, H. B., Li, J., Meniel, V. S., Fennell, C. M., Waring, P., Montgomery, K. G., Rebello, R. J., Macpherson, A. A., Koushyar, S., Furic, L., Cullinane, C., Clarkson, R. W., Smalley, M. J., Simpson, K. J., Phesse, T. J., Shepherd, P. R., Humbert, P. O., Sansom, O. J., Phillips, W. A. (2018) Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery, 8, pp. 764-779. (doi: 10.1158/2159-8290.CD-17-0867)

Godfrey, J. D., Morton, J. P., Wilczynska, A., Sansom, O. J., Bushell, M. D. (2018) MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0628-4)

Roseweir, A. K., Bennett, L., Dickson, A., Cheng, K., Quintayo, M.-A., Bayani, J., McMillan, D. C., Horgan, P. G., van de Velde, C. J.H., Seynaeve, C., Hasenburg, A., Kieback, D. G., Markopoulos, C., Dirix, L. Y., Rea, D. W., Mallon, E. A., Bartlett, J. M.S., Edwards, J. (2018) Predictive biomarkers for endocrine therapy: retrospective study in Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial. Journal of the National Cancer Institute, 110, pp. 616-627. (doi: 10.1093/jnci/djx255)

Woroniuk, A., Porter, A., White, G., Newman, D. T., Diamantopoulou, Z., Waring, T., Rooney, C., Strathdee, D., Marston, D. J., Hahn, K. M., Sansom, O. J., Zech, T., Malliri, A. (2018) STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature Communications, 9, (doi: 10.1038/s41467-018-04404-4)

Sydes, M. R. et al. (2018) Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol. Annals of Oncology, 29, pp. 1235-1248. (doi: 10.1093/annonc/mdy072)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23, pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131)

Serrao, E.M., Kettunen, M.I., Rodrigues, T.B., Lewis, D.Y., Gallagher, F.A., Hu, D.E., Brindle, K.M. (2018) Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate. NMR in Biomedicine, 31, (doi: 10.1002/nbm.3901)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8, pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533)

Galbraith, L., Leung, H. Y., Ahmad, I. (2018) Lipid pathway deregulation in advanced prostate cancer. Pharmacological Research, 131, pp. 177-184. (doi: 10.1016/j.phrs.2018.02.022)

Ahmad, I., Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi: 10.1002/path.5029)

McSorley, S. T., Khor, B. Y., Tsang, K., Colville, D., Han, S., Horgan, P. G., McMillan, D. C. (2018) The relationship between 18F FDG-PETCT derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer. Colorectal Disease, 20, pp. 407-415. (doi: 10.1111/codi.13973)

Hudson, A. M., Stephenson, N. L., Li, C., Trotter, E., Fletcher, A. J., Katona, G., Bieniasz-Krzywiec, P., Howell, M., Wirth, C., Furney, S., Miller, C. J., Brognard, J. (2018) Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. Science Signaling, 11, (doi: 10.1126/scisignal.aan6776)

Patel, R., Fleming, J., Mui, E., Loveridge, C., Repiscak, P., Blomme, A., Harle, V., Salji, M., Ahmad, I., Teo, K., Hamdy, F. C., Hedley, A., van den Broek, N., Mackay, G., Edwards, J., Sansom, O. J., Leung, H. Y. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10, (doi: 10.15252/emmm.201708347)

Schmidinger, M., Danesi, R., Jones, R., McDermott, R., Pyle, L., Rini, B., Négrier, S. (2018) Individualized dosing with axitinib: rationale and practical guidance. Future Oncology, 14, pp. 861-875. (doi: 10.2217/fon-2017-0455)

Alyamani, A.M.A., Quinn, J.A., Greenhalgh, D. A. (2018) Analysis of β-catenin expression in transgenic mouse skin carcinogenesis reveals inhibitory roles in papillomatogenesis and oncogenic roles in malignant conversion.

McMenemy, C., Quinn, J.A., Greenhalgh, D. A. (2018) Fos co-operation with 14-3-3σ [Stratifin] induces malignant conversion in transgenic mouse skin carcinogenesis: a paradigm for SCC of follicular origin.

Woodcock, V. K., Clive, S., Wilson, R. H., Coyle, V. M., Stratford, M. R. L., Folkes, L. K., Eastell, R., Barton, C., Jones, P., Kazmi-Stokes, S., Turner, H., Halford, S., Harris, A. L., Middleton, M. R. (2018) A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424. British Journal of Cancer, 118, pp. 770-776. (doi: 10.1038/bjc.2017.484)

Huels, D.J., Bruens, L., Hodder, M.C., Cammareri, P., Campbell, A.D., Ridgway, R.A., Gay, D.M., Solar Abboud, M., Faller, W.J., Nixon, C., Zeiger, L.B., McLaughlin, M.E., Morrissey, E., Winton, D.J., Snippert, H.J., van Rheenen, J., Sansom, O.J. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, (doi: 10.1038/s41467-018-03426-2)

Parvy, J.-P., Hodgson, J. A., Cordero, J. B. (2018) Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death. BioMed Research International, 2018, (doi: 10.1155/2018/7152962)

Perochon, J., Carroll, L., Cordero, J. (2018) Wnt signalling in intestinal stem cells: lessons from mice and flies. Genes, 9, (doi: 10.3390/genes9030138)

McSorley, S. T., Mansouri, D., Horgan, P. G., McMillan, D. C. (2018) Comment on "the important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial" Annals of Surgery, 267, pp. e49. (doi: 10.1097/SLA.0000000000002053)

Dolan, R., McSorley, S. T., Horgan, P. G., McMillan, D. C. (2018) Determinants of lymph node count and positivity in patients undergoing surgery for colon cancer. Medicine, 97, (doi: 10.1097/MD.0000000000010185)

Adams, R., Brown, E., Brown, L., Butler, R., Falk, S., Fisher, D., Kaplan, R., Quirke, P., Richman, S., Samuel, L., Seligmann, J., Seymour, M., Shiu, K. K., Wasan, H., Wilson, R., Maughan, T. (2018) Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS , and NRAS (FOCUS4-D): a phase 2–3 randomised trial. Lancet Gastroenterology and Hepatology, 3, pp. 162-171. (doi: 10.1016/S2468-1253(17)30394-1)

Patel, M., McSorley, S. T., Park, J. H., Roxburgh, C. S.D., Edwards, J., Horgan, P. G., McMillan, D. C. (2018) The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer. British Journal of Cancer, 118, pp. 705-712. (doi: 10.1038/bjc.2017.441)

Vlachogiannis, G. et al. (2018) Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science, 359, pp. 920-926. (doi: 10.1126/science.aao2774)

Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J., Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37, pp. 982-992. (doi: 10.1038/onc.2017.394)

Rulach, R. J., McKay, S., Neilson, S., White, L., Wallace, J., Carruthers, R., Lamb, C., Cascales, A., Marashi, H., Glen, H., Venugopal, B., Sadoyze, A., Sidek, N., Russell, J. M., Alhasso, A., Dodds, D., Laskey, J., Jones, R. J., MacLeod, N. (2018) Real world uptake, safety profile and outcomes of docetaxel in newly diagnosed metastatic prostate cancer. BJU International, 121, pp. 268-274. (doi: 10.1111/bju.14025)

Campbell, K. J., Dhayade, S., Ferrari, N., Sims, A. H., Johnson, E., Mason, S. M., Dickson, A., Ryan, K. M., Kalna, G., Edwards, J., Tait, S. G.W., Blyth, K. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, (doi: 10.1038/s41419-017-0035-2)

Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J., Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13, (doi: 10.1371/journal.pone.0183585)

Bryant, D. (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131, (doi: 10.1242/jcs.213181)

Almasaudi, A. S., McSorley, S. T., Edwards, C. A., McMillan, D. C. (2018) The relationship between body mass index and short term postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 121, pp. 68-73. (doi: 10.1016/j.critrevonc.2017.12.004)

Bilsland, A., Kelly, C., Roccisana, J., Paul, J., Jones, R., Edwards, J., Roseweir, A., Stein, T., West, K. (2018) An Exploratory Study on the Use of Game-based Learning Using Microsoft Kinect to Teach Oncology Phase I Clinical Trial Designs. (doi: 10.1038/s41416-018-0299-z)

Keith, W. N., Yu, X., Barbeau, R.-M. (2018) Diversity of institutional support for research impact implementation. Zeitschrift für Diversitätsforschung und –management, 3, pp. 199-207.

Dolan, R., Tilling, E., Kong, C. Y., MacLeod, N. J., McSorley, S. T., Park, J. H., Glen, P., Horgan, P. G., Laird, B., McMillan, D. C. (2018) Evaluation of Systemic Inflammation Based Prognostic Scores in Patients with Advanced Oesophageal Cancer Receiving Palliative Radiotherapy.

Ferro, R., Adamska, A., Lattanzio, R., Mavrommati, I., Edling, C.E., Arifin, S.A., Fyffe, C.A., Sala, G., Sacchetto, L., Chiorino, G., De Laurenzi, V., Piantelli, M., Sansom, O.J., Maffucci, T., Falasca, M. (2018) GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine. Oncogene, 37, pp. 6368-6382. (doi: 10.1038/s41388-018-0390-1)

Sierra Gonzalez, P., O'Prey, J., Cardaci, S., Barthet, V. J.A., Sakamaki, J.-i., Beaumatin, F., Roseweir, A., Gay, D. M., Mackay, G., Malviya, G., Kania, E., Ritchie, S., Baudot, A. D., Zunino, B., Mrowinska, A., Nixon, C., Ennis, D., Hoyle, A., Millan, D., Mcneish, I. A., Sansom, O. J., Edwards, J., Ryan, K. M. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi: 10.1038/s41586-018-0729-3)

McClurg, U. L., Chit, N. C.T.H., Azizyan, M., Edwards, J., Nabbi, A., Riabowol, K. T., Nakjang, S., McCracken, S. R., Robson, C. N. (2018) Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. Oncogene, 37, pp. 4679-4691. (doi: 10.1038/s41388-018-0283-3)

Bennett, L., Howell, M., Memon, D., Smowton, C., Zhou, C., Miller, C. J. (2018) Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. Scientific Reports, 8, (doi: 10.1038/s41598-018-33276-3)

Jones, R. J. (2018) Neoadjuvant vs. adjuvant chemotherapy: which is right? Springer

Roxburgh, C. S., Shia, J., Vakiani, E., Daniel, T., Weiser, M. R. (2018) Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer. OncoImmunology, 7, (doi: 10.1080/2162402x.2018.1435227)

Burke, Z. D., Reed, K. R., Yeh, S.-W., Meniel, V., Sansom, O. J., Clarke, A. R., Tosh, D. (2018) Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway. Scientific Reports, 8, (doi: 10.1038/s41598-018-20888-y)

Unal, E. B., Kiel, C., Benisty, H., Campbell, A., Pickering, K., Blüthgen, N., Sansom, O. J., Serrano, L. (2018) Systems level expression correlation of Ras GTPase regulators. Cell Communication and Signaling, 16, (doi: 10.1186/s12964-018-0256-8)

Dolan, R., McSorley, S. T., Park, J. H., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2018) The Prognostic Value of Systemic Inflammation in Patients Undergoing Surgery for Rectal Cancer: Comparison of Composite Ratios and Cumulative Scores. (doi: 10.1200/JCO.2018.36.4_suppl.579)

Jones, R. J. (2018) The role of medical oncologist. Springer

Heinzmann, K., Honess, D. J., Lewis, D. Y., Smith, D.-M., Cawthorne, C., Keen, H., Heskamp, S., Schelhaas, S., Witney, T. H., Soloviev, D., Williams, K. J., Jacobs, A. H., Aboagye, E. O., Griffiths, J. R., Brindle, K. M. (2017) Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Research, 7, (doi: 10.1186/s13550-017-0349-1)

Lawler, M., Alsina, D., Adams, R. A., Anderson, A. S., Brown, G., Fearnhead, N. S., Fenwick, S. W., Halloran, S. P., Hochhauser, D., Hull, M. A., Koelzer, V. H., McNair, A. G.K., Monahan, K. J., Näthke, I., Norton, C., Novelli, M. R., Steele, R. J.C., Thomas, A. L., Wilde, L. M., Wilson, R. H., Tomlinson, I. (2017) Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. Gut, 67, pp. 179-193. (doi: 10.1136/gutjnl-2017-315333)

Rumney, R. M.H., Coffelt, S. B., Neale, T. A., Dhayade, S., Tozer, G. M., Miller, G. (2017) PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development. PLoS ONE, 12, (doi: 10.1371/journal.pone.0188591)

Walton, J. B., Farquharson, M., Mason, S., Port, J., Kruspig, B., Dowson, S., Stevenson, D., Murphy, D., Matzuk, M., Kim, J., Coffelt, S., Blyth, K., Mcneish, I. A. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, (doi: 10.1038/s41598-017-17119-1)

Dolan, R. D., Lim, J., Mcsorley, S. T., Horgan, P. G., McMillan, D. C. (2017) The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis. Scientific Reports, 7, (doi: 10.1038/s41598-017-16955-5)

Lindner, A. U., Salvucci, M., Morgan, C., Monsefi, N., Resler, A. J., Cremona, M., Curry, S., Toomey, S., O'Byrne, R., Bacon, O., Stühler, M., Flanagan, L., Wilson, R., Johnston, P. G., Salto-Tellez, M., Camilleri-Broët, S., McNamara, D. A., Kay, E. W., Hennessy, B. T., Laurent-Puig, P., Van Schaeybroeck, S., Prehn, J. H.M. (2017) BCL-2 system analysis identifies high-risk colorectal cancer patients. Gut, 66, pp. 2141-2148. (doi: 10.1136/gutjnl-2016-312287)

Datta, A., Sandilands, E., Mostov, K. E., Bryant, D. M. (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001)

Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, (doi: 10.1038/s41467-017-01967-6)

Ross, K., Jones, R. J. (2017) Immune checkpoint inhibitors in renal cell carcinoma. Clinical Science, 131, pp. 2627-2642. (doi: 10.1042/CS20160894)

MacLennan, S. et al. (2017) A core outcome set for localised prostate cancer effectiveness trials. BJU International, 120, pp. E64-E79. (doi: 10.1111/bju.13854)

D'Costa, Z., Jones, K., Azad, A., van Stiphout, R., Lim, S. Y., Gomes, A. L., Kinchesh, P., Smart, S. C., Gillies McKenna, W., Buffa, F. M., Sansom, O. J., Muschel, R. J., O'Neill, E., Fokas, E. (2017) Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Research, 77, pp. 5952-5962. (doi: 10.1158/0008-5472.CAN-16-2833)

Schrock, A. B., Devoe, C. E., McWilliams, R., Sun, J., Aparicio, T., Stephens, P. J., Ross, J. S., Wilson, R., Miller, V. A., Ali, S. M., Overman, M. J. (2017) Genomic profiling of small-bowel adenocarcinoma. JAMA Oncology, 3, pp. 1546. (doi: 10.1001/jamaoncol.2017.1051)

Alvi, M. A., Wilson, R. H., Salto-Tellez, M. (2017) Rare cancers: the greatest inequality in cancer research and oncology treatment. British Journal of Cancer, 117, pp. 1255-1257. (doi: 10.1038/bjc.2017.321)

Loveridge, C. J., van ’t Hof, R. J., Charlesworth, G., King, A., Tan, E. H., Rose, L., Daroszewska, A., Prior, A., Ahmad, I., Welsh, M., Mui, E. J., Ford, C., Salji, M., Sansom, O., Blyth, K., Leung, H. Y. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, (doi: 10.1038/s41598-017-13346-8)

Nobis, M. et al. (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21, pp. 274-288. (doi: 10.1016/j.celrep.2017.09.022)

Gao, L., Yang, Z., Hiremath, C., Zimmerman, S. E., Long, B., Brakeman, P. R., Mostov, K. E., Bryant, D. M., Luby-Phelps, K., Marciano, D. K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144, pp. 3511-3520. (doi: 10.1242/dev.148908)

Escudier, B., Faivre, S., Van Cutsem, E., Germann, N., Pouget, J.-C., Plummer, R., Vergote, I., Thistlethwaite, F., Bjarnason, G. A., Jones, R., Mackay, H., Edeline, J., Fartoux, L., Hirte, H., Oza, A. (2017) A phase II multicentre, open-label, proof-of-concept study of tasquinimod in hepatocellular, ovarian, renal cell, and gastric cancers. Targeted Oncology, 12, pp. 655-661. (doi: 10.1007/s11523-017-0525-2)

Phesse, T. J., Durban, V. M., Sansom, O. J. (2017) Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models. Carcinogenesis, 38, pp. 953-965. (doi: 10.1093/carcin/bgx080)

Crabb, S. J., Birtle, A. J., Martin, K., Downs, N., Ratcliffe, I., Maishman, T., Ellis, M., Griffiths, G., Thompson, S., Ksiazek, L., Khoo, V., Jones, R. J. (2017) ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer. Investigational New Drugs, 35, pp. 599-607. (doi: 10.1007/s10637-017-0433-4)

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L.H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J., Sansom, O. J. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24, pp. 1681-1693. (doi: 10.1038/cdd.2017.92)

Chiu, A., Ayub, M., Dive, C., Brady, G., Miller, C. J., Hancock, J. (2017) twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis. Bioinformatics, 33, pp. 2743-2745. (doi: 10.1093/bioinformatics/btx308)

Chuvin, N. et al. (2017) Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS(G12D)-driven pancreatic tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 4, pp. 263-282. (doi: 10.1016/j.jcmgh.2017.05.005)

Dolan, R. D., McSorley, S. T., McMillan, D. C., Horgan, P. G. (2017) Attitudes of surgeons to the use of postoperative markers of the systemic inflammatory response following elective surgery. Annals of Medicine and Surgery, 21, pp. 14-19. (doi: 10.1016/j.amsu.2017.07.046)

Watt, D. G., Ramanathan, M. L., McSorley, S. T., Walley, K., Park, J. H., Horgan, P. G., McMillan, D. C. (2017) Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer. Annals of Surgical Oncology, 24, pp. 2588-2594. (doi: 10.1245/s10434-017-5987-z)

Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R., Suckling, C. J., Sutcliffe, O. B., Young, L. C., Mackay, S. P. (2017) Inhibitory Kappa B kinse α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers. Journal of Medicinal Chemistry, 60, pp. 7043-7066. (doi: 10.1021/acs.jmedchem.7b00484)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36, pp. 2373-2389. (doi: 10.15252/embj.201694912)

Cairney, C. J., Godwin, L. S., Bilsland, A. E., Burns, S., Stevenson, K. H., McGarry, L., Revie, J., Moore, J. D., Wiggins, C. M., Collinson, R. S., Mudd, C., Tsonou, E., Sadaie, M., Bennett, D. C., Narita, M., Torrance, C. J., Keith, W. N. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genetics, 13, (doi: 10.1371/journal.pgen.1006942)

Carron, E. C., Homra, S., Rosenberg, J., Coffelt, S. B., Kittrell, F., Zhang, Y., Creighton, C. J., Fuqua, S. A., Medina, D., Machado, H. L. (2017) Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget, 8, pp. 50731-50746. (doi: 10.18632/oncotarget.14913)

Park, J. H., Roxburgh, C. S.D., Edwards, J., Horgan, P. G., McMillan, D. C. (2017) In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study" Histopathology, 71, pp. 326-327. (doi: 10.1111/his.13195)

Khandelwal, G., Girotti, M. R., Smowton, C., Taylor, S., Wirth, C., Dynowski, M., Frese, K. K., Brady, G., Dive, C., Marais, R., Miller, C. (2017) Next-generation sequencing analysis and algorithms for PDX and CDX models. Molecular Cancer Research, 15, pp. 1012-1016. (doi: 10.1158/1541-7786.MCR-16-0431)

Mcsorley, S. T., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2017) The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer. Annals of Surgical Oncology, 24, pp. 2104-2112. (doi: 10.1245/s10434-017-5817-3)

Dolan, R. D., McSorley, S. T., Horgan, P. G., Laird, B., McMillan, D. C. (2017) The role of the systemic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: Systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 116, pp. 134-146. (doi: 10.1016/j.critrevonc.2017.06.002)

James, N. D. et al. (2017) Abiraterone for prostate cancer not previously treated with hormone therapy. New England Journal of Medicine, 377, pp. 338-351. (doi: 10.1056/NEJMoa1702900)

Tian, A., Benchabane, H., Wang, Z., Zimmerman, C., Xin, N., Perochon, J., Kalna, G., Sansom, O. J., Cheng, C., Cordero, J. B., Ahmed, Y. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13, (doi: 10.1371/journal.pgen.1006870)

Bryant, D., Johnson, A. (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130, pp. 2083-2085. (doi: 10.1242/jcs.205740)

Phesse, T. J., Sansom, O. J. (2017) Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology, 19, pp. 752-754. (doi: 10.1038/ncb3567)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P., Sansom, O. J., Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24, pp. 1303-1304. (doi: 10.1038/cdd.2016.120)

Brindle, K. M., Izquierdo-García, J. L., Lewis, D. Y., Mair, R. J., Wright, A. J. (2017) Brain tumor imaging. Journal of Clinical Oncology, 35, pp. 2432-2438. (doi: 10.1200/JCO.2017.72.7636)

Alderdice, M., Dunne, P. D., Cole, A. J., O’Reilly, P. G., McArt, D. G., Bingham, V., Fuchs, M.-A., McQuaid, S., Loughrey, M. B., Murray, G. I., Samuel, L. M., Lawler, M., Wilson, R. H., Salto-Tellez, M., Coyle, V. M. (2017) Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival. Modern Pathology, 30, pp. 1287-1298. (doi: 10.1038/modpathol.2017.47)

Kelly, A. U., McSorley, S. T., Patel, P., Talwar, D. (2017) Interpreting iron studies. British Medical Journal, 357, (doi: 10.1136/bmj.j2513)

Alvi, M. A., Loughrey, M. B., Dunne, P., McQuaid, S., Turkington, R., Fuchs, M.-A., McGready, C., Bingham, V., Pang, B., Moore, W., Maxwell, P., Lawler, M., James, J. A., Murray, G. I., Wilson, R. H., Salto-Tellez, M. (2017) Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies. British Journal of Cancer, 117, pp. 203-209. (doi: 10.1038/bjc.2017.168)

Jones, R. J., Hussain, S. A., Protheroe, A. S., Birtle, A., Chakraborti, P., Huddart, R. A., Jagdev, S., Bahl, A., Stockdale, A., Sundar, S., Crabb, S. J., Dixon-Hughes, J., Alexander, L., Morris, A., Kelly, C., Stobo, J., Paul, J., Powles, T. (2017) Randomized phase II study investigating pazopanib versus weekly paclitaxel in relapsed or progressive urothelial cancer. Journal of Clinical Oncology, 35, pp. 1770-1777. (doi: 10.1200/JCO.2016.70.7828)

Neves, A. A., Xie, B., Fawcett, S., Alam, I. S., Witney, T. H., de Backer, M. M., Summers, J., Hughes, W., McGuire, S., Soloviev, D., Miller, J., Howat, W. J., Hu, D.-e., Rodrigues, T. B., Lewis, D. Y., Brindle, K. M. (2017) Rapid imaging of tumor cell death in vivo using the c2a domain of synaptotagmin-I. Journal of Nuclear Medicine, 58, pp. 881-887. (doi: 10.2967/jnumed.116.183004)

Roseweir, A. K., McMillan, D. C., Horgan, P. G., Edwards, J. (2017) Colorectal cancer subtypes: Translation to routine clinical pathology. Cancer Treatment Reviews, 57, pp. 1-7. (doi: 10.1016/j.ctrv.2017.04.006)

Loveridge, C. J., Mui, E. J., Patel, R., Tan, E. H., Ahmad, I., Welsh, M., Galbraith, J., Hedley, A., Nixon, C., Blyth, K., Sansom, O., Leung, H. Y. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77, pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565)

Roseweir, A. K., McCall, P., Scott, A., Liew, B., Lim, Z., Mallon, E. A., Edwards, J. (2017) Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer. Oncotarget, 8, pp. 37172-37185. (doi: 10.18632/oncotarget.16420)

Gore, M. E., Jones, R. J., Ravaud, A., Kuczyk, M., Demkow, T., Bearz, A., Shapiro, J., Strauss, U. P., Porta, C. (2017) Sorafenib dose escalation in treatment-naïve patients with metastatic renal cell carcinoma: a non-randomised, open-label, Phase 2b study. BJU International, 119, pp. 846-853. (doi: 10.1111/bju.13740)

Park, J.H., Van Wyk, H., Roxburgh, C.S.D., Horgan, P.G., Edwards, J., McMillan, D.C. (2017) Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer. British Journal of Cancer, 116, pp. 1444-1450. (doi: 10.1038/bjc.2017.108)

Bennett, L., Mallon, E. A., Horgan, P. G., Paul, A., McMillan, D. C., Edwards, J. (2017) The relationship between members of the canonical NF-KB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer. Oncotarget, 8, pp. 33002-33013. (doi: 10.18632/oncotarget.16031)

Mason, M. D. et al. (2017) Adding celecoxib with or without zoledronic acid for hormone-naïve prostate cancer: long-term survival results from an adaptive, multiarm, multistage, platform, randomized controlled trial. Journal of Clinical Oncology, 35, pp. 1530-1541. (doi: 10.1200/JCO.2016.69.0677)

Diamantopoulou, Z., White, G., Fadlullah, M. Z.H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. F.L., Malliri, A. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31, pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007)

Dreyer, S. B., Powell, A. G.M.T., McSorley, S. T., Waterston, A., Going, J. J., Edwards, J., McMillan, D. C., Horgan, P. G. (2017) The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer. Annals of Surgical Oncology, 24, pp. 1295-1303. (doi: 10.1245/s10434-016-5684-3)

Zhang, Q., Kersemans, V., Beech, J. S., Gilchrist, S., Kinchesh, P., Allen, P. D., Thompson, J., Gomes, A. L., D’Costa, Z., Bird, L., Tullis, I. D.C., Newman, R. G., Corroyer-Dulmont, A., Falzone, N., Azad, A., Vallis, K. A., Sansom, O. J., Muschel, R. J., Vojnovic, B., Hill, M. A., Fokas, E., Smart, S. C. (2017) An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse. PLoS ONE, 12, (doi: 10.1371/journal.pone.0176693)

McSorley, S. T., Roxburgh, C. S., Horgan, P. G., McMillan, D. C. (2017) Re: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) British Medical Journal, 357,

Maddocks, O. D.K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J.F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., Blagih, J., Vincent, D. F., Campbell, K. J., Ceteci, F., Sansom, O. J., Blyth, K., Vousden, K. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544, pp. 372-376. (doi: 10.1038/nature22056)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9, (doi: 10.1126/scitranslmed.aai8504)

Watt, D., Mcsorley, S. T., Park, J. H., Horgan, P. G., McMillan, D. C. (2017) A postoperative systemic inflammation score predicts short- and long-term outcomes in patients undergoing surgery for colorectal cancer. Annals of Surgical Oncology, 24, pp. 1100-1109. (doi: 10.1245/s10434-016-5659-4)

Jones, R. J., Brown, J. (2017) Circulating biomarkers in cancer care: what possible use? Practical Laboratory Medicine, 7, pp. 45-48. (doi: 10.1016/j.plabm.2016.04.004)

Bennett, L., Quinn, J., McCall, P., Mallon, E. A., Horgan, P. G., McMillan, D. C., Paul, A., Edwards, J. (2017) High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. International Journal of Cancer, 140, pp. 1633-1644. (doi: 10.1002/ijc.30578)

Tan, W. S., Lamb, B. W., Tan, M.-Y., Ahmad, I., Sridhar, A., Nathan, S., Hines, J., Shaw, G., Briggs, T. P., Kelly, J. D. (2017) In-depth critical analysis of complications following robot-assisted radical cystectomy with intracorporeal urinary diversion. European Urology Focus, 3, pp. 273-279. (doi: 10.1016/j.euf.2016.06.002)

Park, J. H., Van Wyk, H. C., McMillan, D. C., Quinn, J. A., Clark, J., Roxburgh, C., Horgan, P. G., Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23, pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416)

Cheng, K. K.W., Dickson, A., Gujam, F. J.A., McMillan, D. C., Edwards, J. (2017) The relationship between oestrogen receptor-alpha phosphorylation and the tumour microenvironment in patients with primary operable ductal breast cancer. Histopathology, 70, pp. 782-797. (doi: 10.1111/his.13134)

Letsolo, B. T., Jones, R. E., Rowson, J., Grimstead, J. W., Keith, W. N., Jenkins, G. J.S., Baird, D. M. (2017) Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia. PLoS ONE, 12, (doi: 10.1371/journal.pone.0174833)

Gundry, C., Marco, S., Rainero, E., Miller, B., Dornier, E., Mitchell, L., Caswell, P. T., Campbell, A., Hogeweg, A., Sansom, O. J., Morton, J. P., Norman, J. C. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, (doi: 10.1038/ncomms14646)

Fumagalli, A., Drost, J., Suijkerbuijk, S. J.E., van Boxtel, R., de Ligt, J., Offerhaus, G. J., Begthel, H., Beerling, E., Tan, E. H., Sansom, O. J., Cuppen, E., Clevers, H., van Rheenen, J. (2017) Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E2357-E2364. (doi: 10.1073/pnas.1701219114)

Salvucci, M. et al. (2017) A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer. Clinical Cancer Research, 23, pp. 1200-1212. (doi: 10.1158/1078-0432.CCR-16-1084)

Dolan, R., McSorley, S. T., McMillan, D. C., Horgan, P. G. (2017) Association of Ongoing Systemic Inflammatory Response (SIR) at Diagnosis With Lymph Node Retrieval and Node Positivity in Patients Undergoing Surgery for Colonic Cancer. (doi: 10.1200/jco.2017.35.4_suppl.550)

Dolan, R., MacLeod, N. J., McSorley, S. T., Horgan, P. G., Laird, B., McMillan, D. C. (2017) Evaluation of Systemic Inflammation-based Prognostic Scores in Patients With Advanced Colorectal Cancer Receiving Palliative Pelvic Radiotherapy (RT) (doi: 10.1200/jco.2017.35.4_suppl.558)

Myant, K. B., Cammareri, P., Hodder, M. C., Wills, J., Von Kriegsheim, A., Győrffy, B., Rashid, M., Polo, S., Maspero, E., Vaughan, L., Gurung, B., Barry, E., Malliri, A., Camargo, F., Adams, D. J., Iavarone, A., Lasorella, A., Sansom, O. J. (2017) HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. EMBO Molecular Medicine, 9, pp. 181-197. (doi: 10.15252/emmm.201606684)

Azad, A., Yin Lim, S., D'Costa, Z., Jones, K., Diana, A., Sansom, O. J., Kruger, P., Liu, S., McKenna, W. G., Dushek, O., Muschel, R. J., Fokas, E. (2017) PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Molecular Medicine, 9, pp. 167-180. (doi: 10.15252/emmm.201606674)

Smowton, C., Balla, A., Antoniades, D., Miller, C., Pallis, G., Dikaiakos, M. D., Xing, W. (2017) A cost-effective approach to improving performance of big genomic data analyses in clouds. Future Generation Computer Systems, 67, pp. 368-381. (doi: 10.1016/j.future.2015.11.011)

Mcsorley, S. T., Khor, B. Y., MacKJay, G. J., Horgan, P. G., McMillan, D. C. (2017) Examination of a CRP first approach for the detection of postoperative complications in patients undergoing surgery for colorectal cancer: a pragmatic study. Medicine, 96, (doi: 10.1097/MD.0000000000006133)

van Baal, J.O.A.M., Van de Vijver, K.K., Coffelt, S.B., van der Noort, V., van Driel, W.J., Kenter, G.G., Buist, M.R., Lok, C.A.R. (2017) Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 486-494. (doi: 10.1111/1471-0528.14425)

Ruch, T. R., Bryant, D. M., Mostov, K. E., Engel, J. N., Yap, A. (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28, pp. 252-260. (doi: 10.1091/mbc.E16-07-0541)

van der Weyden, L., Arends, M. J., Campbell, A. D., Bald, T., Wardle-Jones, H., Griggs, N., Del Castillo Velasco-Herrera, M., Tüting, T., Sansom, O. J., Karp, N. A., Clare, S., Gleeson, D., Ryder, E., Galli, A., Tuck, E., Cambridge, E. L., Voet, T., Macaulay, I. C., Wong, K., Spiegel, S., Speak, A. O., Adams, D. J. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541, pp. 233-236. (doi: 10.1038/nature20792)

Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I., Edwards, J., Zanivan, S., Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130, pp. 697-711. (doi: 10.1242/jcs.190835)

Jackstadt, R., Sansom, O. J. (2017) The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. EMBO Journal, 36, pp. 3-4. (doi: 10.15252/embj.201695973)

Morton, J. P., Sansom, O. J. (2017) CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy? Immunotherapy, 9, pp. 9-12. (doi: 10.2217/imt-2016-0115)

Humphris, J. L. et al. (2017) Hypermutation in pancreatic cancer. Gastroenterology, 152, pp. 68-74.e2. (doi: 10.1053/j.gastro.2016.09.060)

Powles, T., Huddart, R. A., Elliott, T., Sarker, S.-J., Ackerman, C., Jones, R., Hussain, S., Crabb, S., Jagdev, S., Chester, J., Hilman, S., Beresford, M., Macdonald, G., Santhanam, S., Frew, J. A., Stockdale, A., Hughes, S., Berney, D., Chowdhury, S. (2017) Phase III, double-blind, randomized trial that compared maintenance lapatinib versus placebo after first-line chemotherapy in patients with human epidermal growth factor receptor 1/2-positive metastatic bladder cancer. Journal of Clinical Oncology, 35, pp. 48-55. (doi: 10.1200/JCO.2015.66.3468)

Khor, B. Y., McSorley, S. T., Horgan, P. G., McMillan, D. C. (2017) The relationship between systemic inflammation and stoma formation following anterior resection for rectal cancer: a cross-sectional study. International Journal of Surgery, 37, pp. 79-84. (doi: 10.1016/j.ijsu.2016.12.010)

Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., Keyes, W. M. (2017) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes and Development, 31, pp. 172-183. (doi: 10.1101/gad.290635.116)

McMenemy, C., Guo, D., Cochrane, A., Crookston, K., Boyle, J., Quinn, J., Greenhalgh, D. A. (2017) 14-3-3σ/Stratifin Expression in HK1.Ras/Fos-Δ5ptenflx Transgenic Mouse Skin Carcinogenesis Reveals an Early, Inhibitory Role; Lost During MDM2 Activated/P53 Inactivated Malignant Progression.

Dolan, R., McLeod, N., McSorley, S., McMillan, D., Horgan, P. (2017) Evaluation of Systemic Inflammation Based Prognostic Scoresin Patients with Advanced Rectal Cancer Receiving Palliative Pelvicradiotherapy.

McSorley, S. T., Dolan, R. D., Roxburgh, C. S.D., McMillan, D. C., Horgan, P. G. (2017) How and why systemic inflammation worsens quality of life in patients with advanced cancer. Expert Review of Quality of Life in Cancer Care, 2, pp. 167-175. (doi: 10.1080/23809000.2017.1331705)

Rose, A. M., Sansom, O. J., Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16, pp. 386-387. (doi: 10.1080/15384101.2016.1259892)

Kersten, K., Coffelt, S. B., Hoogstraat, M., Verstegen, N. J.M., Vrijland, K., Ciampricotti, M., Doornebal, C. W., Hau, C.-S., Wellenstein, M. D., Salvagno, C., Doshi, P., Lips, E. H., Wessels, L. F.A., de Visser, K. E. (2017) Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. OncoImmunology, 6, (doi: 10.1080/2162402X.2017.1334744)

Carter, L., Rothwell, D. G., Mesquita, B., Smowton, C., Leong, H. S., Fernandez-Gutierrez, F., Li, Y., Burt, D. J., Antonello, J., Morrow, C. J., Hodgkinson, C. L., Morris, K., Priest, L., Carter, M., Miller, C., Hughes, A., Blackhall, F., Dive, C., Brady, G. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23, pp. 114-119. (doi: 10.1038/nm.4239)

Draper, J. E., Sroczynska, P., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130, pp. 271-284. (doi: 10.1182/blood-2016-06-723635)

Dolan, R., McSorley, S., McMillan, D., Horgan, P. (2017) Ongoing Systemic Inflammatory Response at Diagnosis is Notassociated with Lower Lymph Node Retrieval and Higher Node Positivityin Patients Undergoing Surgery for Colonic Cancer.

Wildenberg, M.E., Koelink, P.J., Diederen, K., te Velde, A.A., Wolfkamp, S.C.S., Nuij, V.J., Peppelenbosch, M.P., Nobis, M., Sansom, O.J., Anderson, K.I., van der Woude, C.J., D’Haens, G.R.A.M., van den Brink, G.R. (2017) The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunology, 10, pp. 352-360. (doi: 10.1038/mi.2016.65)

Little, C. H., Combet, E., McMillan, D. C., Horgan, P. G., Roxburgh, C. S.D. (2017) The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer. Critical Reviews in Food Science and Nutrition, 57, pp. 2310-2320. (doi: 10.1080/10408398.2014.997866)

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Girotti, M. R., Sibbet, G., Higgs, E. B., Shuttleworth, M. K., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., Dijke, P. t., Marais, R., Inman, G. J. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget, 7, pp. 81995-82012. (doi: 10.18632/oncotarget.13226)

Reza, M., Jones, R., Aspegren, J., Massard, C., Mattila, L., Mustonen, M., Wollmer, P., Trägårdh, E., Bondesson, E., Edenbrandt, L., Fizazi, K., Bjartell, A. (2016) Bone scan index and progression-free survival data for progressive metastatic castration-resistant prostate cancer patients who received ODM-201 in the ARADES multicentre study. European Urology Focus, 2, pp. 547-552. (doi: 10.1016/j.euf.2016.01.005)

Bryant, D. M., Yap, A. S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17, pp. 1231-1232. (doi: 10.1111/tra.12433)

Driscoll, D. R., Karim, S. A., Sano, M., Gay, D. M., Jacob, W., Yu, J., Mizukami, Y., Gopinathan, A., Jodrell, D. I., Evans, T.R. J., Bardeesy, N., Hall, M. N., Quattrochi, B. J., Klimstra, D. S., Barry, S. T., Sansom, O. J., Lewis, B. C., Morton, J. P. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76, pp. 6911-6923. (doi: 10.1158/0008-5472.CAN-16-0810)

Bangi, E., Murgia, C., Teague, A. G.S., Sansom, O. J., Cagan, R. L. (2016) Functional exploration of colorectal cancer genomes using Drosophila. Nature Communications, 7, (doi: 10.1038/ncomms13615)

Patek, S.C., Willder, J.M., Heng, J.S., Taylor, B., Horgan, P.G., Leung, H.Y., Underwood, M.A., Edwards, J. (2016) Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients. Oncotarget, 8, pp. 4875-4887. (doi: 10.18632/oncotarget.13608)

Roman-Fernandez, A., Bryant, D. M. (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17, pp. 1244-1261. (doi: 10.1111/tra.12417)

Williamson, S. C. et al. (2016) Vasculogenic mimicry in small cell lung cancer. Nature Communications, 7, (doi: 10.1038/ncomms13322)

Jamieson, D., Griffin, M. J., Sludden, J., Drew, Y., Cresti, N., Swales, K., Merriman, M., Allen, R., Bevan, P., Buerkle, M., Mala, C., Coyle, V., Rodgers, L., Dean, E., Greystoke, A., Banerji, U., Wilson, R. H., Evans, T.R. J., Anthoney, A., Ranson, M., Boddy, A. V., Plummer, R. (2016) A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours. European Journal of Cancer, 68, pp. 1-10. (doi: 10.1016/j.ejca.2016.08.026)

Coyle, C., Cafferty, F. H., Rowley, S., MacKenzie, M., Berkman, L., Gupta, S., Pramesh, C.S., Gilbert, D., Kynaston, H., Cameron, D., Wilson, R. H., Ring, A., Langley, R. E. (2016) ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. Contemporary Clinical Trials, 51, pp. 56-64. (doi: 10.1016/j.cct.2016.10.004)

Hatziieremia, S., Mohammed, Z., McCall, P., Willder, J. M., Roseweir, A. K., Underwood, M. A., Edwards, J. (2016) Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence. Molecular Carcinogenesis, 55, pp. 1667-1677. (doi: 10.1002/mc.22417)

Salji, M., Ahmad, I., Winchester, C. (2016) Non-clinical research – laboratory based. Journal of Clinical Urology, 9, pp. 362-364. (doi: 10.1177/2051415816650134)

Koppens, M. A.J., Bounova, G., Cornelissen-Steijger, P., de Vries, N., Sansom, O. J., Wessels, L. F.A., van Lohuizen, M. (2016) Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget, 7, pp. 69816-69828. (doi: 10.18632/oncotarget.12002)

Guest, R. V., Boulter, L., Dwyer, B. J., Kendall, T. J., Man, T.-Y., Minnis-Lyons, S. E., Lu, W.-Y., Robson, A. J., Gonzalez, S. F., Raven, A., Wojtacha, D., Morton, J. P., Komuta, M., Roskams, T., Wigmore, S. J., Sansom, O. J., Forbes, S. J. (2016) Notch3 drives development and progression of cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 12250-12255. (doi: 10.1073/pnas.1600067113)

Gujam, F. J.A., McMillan, D. C., Edwards, J. (2016) The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer. Oncotarget, 7, pp. 77607-77621. (doi: 10.18632/oncotarget.12730)

Campbell, E. J., Tesson, M., Doogan, F., Mohammed, Z. M.A., Mallon, E., Edwards, J. (2016) The combined endocrine receptor in breast cancer, a novel approach to traditional hormone receptor interpretation and a better discriminator of outcome than ER and PR alone. British Journal of Cancer, 115, pp. 967-973. (doi: 10.1038/bjc.2016.206)

Patel, S. V., Roxburgh, C. S., Vakiani, E., Shia, J., Smith, J. J., Temple, L. K., Paty, P., Garcia-Aguilar, J., Nash, G., Guillem, J., Wu, A., Reyngold, M., Weiser, M. R. (2016) Distance to the anal verge is associated with pathologic complete response to neoadjuvant therapy in locally advanced rectal cancer. Journal of Surgical Oncology, 114, pp. 637-641. (doi: 10.1002/jso.24358)

Yang, Z., Zimmerman, S. E., Tsunezumi, J., Braitsch, C., Trent, C., Bryant, D. M., Cleaver, O., González-Manchón, C., Marciano, D. K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418, pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009)

Kumar, N., Srivillibhuthur, M., Joshi, S., Walton, K. D., Zhou, A., Faller, W. J., Perekatt, A. O., Sansom, O. J., Gumucio, D. L., Xing, J., Bonder, E. M., Gao, N., White, E., Verzi, M. P. (2016) A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development, 143, pp. 3711-3722. (doi: 10.1242/dev.137992)

Mcsorley, S. T., Jones, I., McMillan, D. C., Talwar, D. (2016) Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status. Translational Research, 176, pp. 119-126. (doi: 10.1016/j.trsl.2016.05.004)

Roseweir, A. K., Powell, A. G.M.T., Bennett, L., Van Wyk, H. C., Park, J., McMillan, D. C., Horgan, P. G., Edwards, J. (2016) Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. Oncotarget, 7, pp. 70601-70612. (doi: 10.18632/oncotarget.12134)

Powles, T., Sarwar, N., Stockdale, A., Sarker, S.-J., Boleti, E., Protheroe, A., Jones, R., Chowdhury, S., Peters, J., Oades, G., O’Brien, T., Sullivan, M., Aitchison, M., Beltran, L., Worth, D., Smith, K., Michel, C., Trevisan, G., Harvey-Jones, E., Wimalasingham, A., Sahdev, A., Ackerman, C., Crabb, S. (2016) Safety and efficacy of pazopanib therapy prior to planned nephrectomy in metastatic clear cell renal cancer. JAMA Oncology, 2, pp. 1303-1309. (doi: 10.1001/jamaoncol.2016.1197)

Birch, J., Clarke, C., Campbell, A. D., Campbell, K., Mitchell, L., Liko, D., Kalna, G., Strathdee, D., Sansom, O. J., Neilson, M., Blyth, K., Norman, J. C. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5, pp. 1371-1379. (doi: 10.1242/bio.019075)

Lamb, B. W., Tan, W. S., Eneje, P., Bruce, D., Jones, A., Ahmad, I., Sridhar, A., Baker, H., Briggs, T. P., Hines, J. E., Nathan, S., Martin, D., Stephens, R. C., Kelly, J. D. (2016) Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: a prospective cohort study. Urologic Oncology: Seminars and Original Investigations, 34, pp. 417.e17-417.e23. (doi: 10.1016/j.urolonc.2016.04.006)

McSorley, S. T., Watt, D. G., Horgan, P. G., McMillan, D. C. (2016) Postoperative systemic inflammatory response, complication severity, and survival following surgery for colorectal cancer. Annals of Surgical Oncology, 23, pp. 2832-2840. (doi: 10.1245/s10434-016-5204-5)

Cammareri, P. et al. (2016) Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications, 7, (doi: 10.1038/ncomms12493)

Heinzmann, K., Honess, D. J., Lewis, D. Y., Smith, D.-M., Cawthorne, C., Keen, H., Heskamp, S., Schelhaas, S., Witney, T. H., Soloviev, D., Williams, K. J., Jacobs, A. H., Aboagye, E. O., Griffiths, J. R., Brindle, K. M. (2016) The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Research, 6, (doi: 10.1186/s13550-016-0218-3)

Lesina, M., Wörmann, S. M., Morton, J., Diakopoulos, K. N., Korneeva, O., Wimmer, M., Einwächter, H., Sperveslage, J., Demir, I. E., Kehl, T., Saur, D., Sipos, B., Heikenwälder, M., Steiner, J. M., Wang, T. C., Sansom, O. J., Schmid, R. M., Algül, H. (2016) RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. Journal of Clinical Investigation, 126, pp. 2919-2932. (doi: 10.1172/jci86477)

Memon, D., Dawson, K., Smowton, C. S., Xing, W., Dive, C., Miller, C. J. (2016) Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response. npj Genomic Medicine, 1, (doi: 10.1038/npjgenmed.2016.20)

Sinclair, A., Park, L., Shah, M., Drotar, M., Calaminus, S., Hopcroft, L. E.M., Kinstrie, R., Guitart, A. V., Dunn, K., Abraham, S. A., Sansom, O., Michie, A. M., Machesky, L., Kranc, K. R., Graham, G. J., Pellicano, F., Holyoake, T. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128, pp. 371-383. (doi: 10.1182/blood-2015-08-661785)

Ahmad, I., Mui, E., Galbraith, L., Patel, R., Tan, E. H., Salji, M., Rust, A. G., Repiscak, P., Hedley, A., Markert, E., Loveridge, C., van der Weyden, L., Edwards, J., Sansom, O. J., Adams, D. J., Leung, H. Y. (2016) Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 8290-8295. (doi: 10.1073/pnas.1601571113)

Carter, L. R., Rothwell, D. G., Leong, H., Li, Y., Burt, D. J., Antonello, J., Hodgkinson, C., Morris, K., Franklin, L., Miller, C. J., Blackhall, F., Dive, C., Brady, G. (2016) Abstract 3155: Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells. (doi: 10.1158/1538-7445.AM2016-3155)

van Wyk, H. C., Park, J. H., Edwards, J., Horgan, P. G., McMillan, D. C., Going, J. J. (2016) The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer. British Journal of Cancer, 115, pp. 156-163. (doi: 10.1038/bjc.2016.173)

Gao, Y., Vincent, D., Davis, A. J., Sansom, O., Bartholin, L., Li, Q. (2016) Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. Oncotarget, 7, pp. 40904-40918. (doi: 10.18632/oncotarget.10149)

Wörmann, S. M., Song, L., Ai, J., Diakopoulos, K. N., Kurkowski, M. U., Görgülü, K., Ruess, D., Campbell, A., Doglioni, C., Jodrell, D., Neesse, A., Demir, I. E., Karpathaki, A.-P., Barenboim, M., Hagemann, T., Rose-John, S., Sansom, O., Schmid, R. M., Protti, M. P., Lesina, M., Algül, H. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151, pp. 180-193.e12. (doi: 10.1053/j.gastro.2016.03.010)

Coffelt, S. B., Wellenstein, M. D., de Visser, K. E. (2016) Neutrophils in cancer: neutral no more. Nature Reviews Cancer, 16, pp. 431-446. (doi: 10.1038/nrc.2016.52)

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29, pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014)

Conteduca, V., Crabb, S. J., Scarpi, E., Hanna, C., Maines, F., Joyce, H., Fabbri, P., Derosa, L., Massari, F., Lolli, C., Zarif, S., Jones, R., Caffo, O., Elliott, T., De Giorgi, U. (2016) Association between early PSA increase and clinical outcome in patients treated with enzalutamide for metastatic castration resistant prostate cancer. Molecular Diagnosis and Therapy, 20, pp. 255-263. (doi: 10.1007/s40291-016-0196-1)

Davda, R., Hughes, S., Jones, R., Crabb, S.J., Troup, J., Payne, H. (2016) Chemotherapy at first diagnosis of advanced prostate cancer – revolution or evolution? Findings from a British uro-oncology group UK survey to evaluate oncologists' views on first-line docetaxel in combination with androgen deprivation therapy in castrate-sensitive metastatic and high-risk/locally advanced prostate cancer. Clinical Oncology, 28, pp. 376-385. (doi: 10.1016/j.clon.2016.01.006)

Graham, D. M., Coyle, V. M., Kennedy, R. D., Wilson, R. H. (2016) Molecular subtypes and personalized therapy in metastatic colorectal cancer. Current Colorectal Cancer Reports, 12, pp. 141-150. (doi: 10.1007/s11888-016-0312-y)

Morrow, C.J., Trapani, F., Metcalf, R.L., Bertolini, G., Hodgkinson, C.L., Khandelwal, G., Kelly, P., Galvin, M., Carter, L., Simpson, K.L., Williamson, S., Wirth, C., Simms, N., Frankliln, L., Frese, K.K., Rothwell, D.G., Nonaka, D., Miller, C.J., Brady, G., Blackhall, F.H., Dive, C. (2016) Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Annals of Oncology, 27, pp. 1155-1160. (doi: 10.1093/annonc/mdw122)

Scopelliti, A., Bauer, C., Cordero, J. B., Vidal, M. (2016) Bursicon-α subunit modulates dLGR2 activity in the adultDrosophila melanogastermidgut independently to Bursicon-β. Cell Cycle, 15, pp. 1538-1544. (doi: 10.1080/15384101.2015.1121334)

Tape, C. J., Ling, S., Dimitriadi, M., McMahon, K. M., Worboys, J. D., Leong, H. S., Norrie, I. C., Miller, C., Poulogiannis, G., Lauffenburger, D. A., Jørgensen, C. (2016) Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 165, pp. 910-920. (doi: 10.1016/j.cell.2016.03.029)

ORIGIN Trial Investigators, (2016) Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE) Diabetes Care, 39, pp. 709-716. (doi: 10.2337/dc15-1676)

Coffelt, S. B., de Visser, K. E. (2016) Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor. Immunity, 44, pp. 722-724. (doi: 10.1016/j.immuni.2016.03.014)

Rothwell, D. G., Smith, N., Morris, D., Leong, H. S., Li, Y., Hollebecque, A., Ayub, M., Carter, L., Antonello, J., Franklin, L., Miller, C., Blackhall, F., Dive, C., Brady, G. (2016) Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample. Molecular Oncology, 10, pp. 566-574. (doi: 10.1016/j.molonc.2015.11.006)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26, pp. 755-765. (doi: 10.1016/j.cub.2016.01.045)

Bailey, P. et al. (2016) Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 531, pp. 47-52. (doi: 10.1038/nature16965)

Lawler, M., Gavin, A., Salto-Tellez, M., Kennedy, R. D., Van Schaeybroeck, S., Wilson, R. H., Harkin, D. P., Grayson, M., Boyd, R. E., Hamilton, P. W., McArt, D. G., James, J., Robson, T., Ladner, R. D., Prise, K. M., O'Sullivan, J. M., Harrison, T., Murray, L., Johnston, P. G., Waugh, D. J. (2016) Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program. Cancer, 122, pp. 664-673. (doi: 10.1002/cncr.29814)

Cagan, R., Gottlieb, E. (2016) In memory of Marcos Vidal (1974-2016) Disease Models and Mechanisms, 9, pp. 233-233. (doi: 10.1242/dmm.024612)

Pitsiladis, Y. P., Tanaka, M., Eynon, N., Bouchard, C., North, K. N., Williams, A. G., Collins, M., Moran, C. N., Britton, S. L., Fuku, N., Ashley, E. A., Klissouras, V., Lucia, A., Ahmetov, I. I., de Geus, E., Alsayrafi, M., Athlome Project Consortium, , , (2016) Athlome Project Consortium: a concerted effort to discover genomic and other “omic” markers of athletic performance. Physiological Genomics, 48, pp. 183-190. (doi: 10.1152/physiolgenomics.00105.2015)

Park, J. H., McMillan, D. C., Edwards, J., Horgan, P. G., Roxburgh, C. S.D. (2016) Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer. OncoImmunology, 5, (doi: 10.1080/2162402X.2015.1098801)

Armstrong, A. J., Halabi, S., Eisen, T., Broderick, S., Stadler, W. M., Jones, R. J., Garcia, J. A., Vaishampayan, U. N., Picus, J., Hawkins, R. E., Hainsworth, J. D., Kollmannsberger, C. K., Logan, T. F., Puzanov, I., Pickering, L. M., Ryan, C. W., Protheroe, A., Lusk, C. M., Oberg, S., George, D. J. (2016) Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial. Lancet Oncology, 17, pp. 378-388. (doi: 10.1016/S1470-2045(15)00515-X)

Serrao, E. M., Kettunen, M. I., Rodrigues, T. B., Dzien, P., Wright, A. J., Gopinathan, A., Gallagher, F. A., Lewis, D. Y., Frese, K. K., Almeida, J., Howat, W. J., Tuveson, D. A., Brindle, K. M. (2016) MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut, 65, pp. 465-475. (doi: 10.1136/gutjnl-2015-310114)

Naszai, M., Cordero, J. (2016) Intestinal stem cells: got calcium? Current Biology, 26, pp. R117-R119. (doi: 10.1016/j.cub.2015.12.012)

Park, J. H., Watt, D. G., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. C. (2016) Colorectal cancer, systemic inflammation, and outcome: staging the tumor and staging the host. Annals of Surgery, 263, pp. 326-336. (doi: 10.1097/SLA.0000000000001122)

Matzke-Ogi, A., Jannasch, K., Shatirishvili, M., Fuchs, B., Chiblak, S., Morton, J., Tawk, B., Lindner, T., Sansom, O., Alves, F., Warth, A., Schwager, C., Mier, W., Kleeff, J., Ponta, H., Abdollahi, A., Orian-Rousseau, V. (2016) Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling. Gastroenterology, 150, pp. 513-525.e10. (doi: 10.1053/j.gastro.2015.10.020)

Marusiak, A. A., Stephenson, N. L., Baik, H., Trotter, E. W., Li, Y., Blyth, K., Mason, S., Chapman, P., Puto, L. A., Read, J. A., Brassington, C., Pollard, H. K., Phillips, C., Green, I., Overman, R., Collier, M., Testoni, E., Miller, C.J., Hunter, T., Sansom, O.J., Brognard, J. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76, pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t)

Grimes, H. L., Draper, J. E., Sroczynska, P., Tsoulaki, O., Leong, H. S., Fadlullah, M. Z. H., Miller, C., Kouskoff, V., Lacaud, G. (2016) RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis. PLoS Genetics, 12, (doi: 10.1371/journal.pgen.1005814)

Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14, pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020)

Cheung, E., Lee, P., Ceteci, F., Nixon, C., Blyth, K., Sansom, O., Vousden, K. (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes and Development, 30, pp. 52-63. (doi: 10.1101/gad.271130.115)

Dunne, P.D., Dasgupta, S., Blayney, J.K., McArt, D.G., Redmond, K. L., Weir, J.-A., Bradley, C.A., Sasazuki, T., Shirasawa, S., Wang, T., Srivastava, S., Ong, C.W., Arthur, K., Salto-Tellez, M., Wilson, R.H., Johnston, P.G., Van Schaeybroeck, S. (2016) EphA2 expression is a key driver of migration and invasion and a poor prognostic marker in colorectal cancer. Clinical Cancer Research, 22, pp. 230-242. (doi: 10.1158/1078-0432.CCR-15-0603)

Jackstadt, R., Sansom, O. (2016) Mouse models of intestinal cancer. Journal of Pathology, 238, pp. 141-151. (doi: 10.1002/path.4645)

McSorley, S. T., Horgan, P. G., McMillan, D. C. (2016) The impact of the type and severity of postoperative complications on long-term outcomes following surgery for colorectal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 97, pp. 168-177. (doi: 10.1016/j.critrevonc.2015.08.013)

Roxburgh, C., McMillan, D. (2016) Therapeutics targeting innate immune/inflammatory responses through the interleukin-6/JAK/STAT signal transduction pathway in patients with cancer. Translational Research, 167, pp. 61-66. (doi: 10.1016/j.trsl.2015.08.013)

Wagstaff, J., Jones, R., Hawkins, R., Porfiri, E., Pickering, L., Bahl, A., Brown, J., Buchan, S. (2016) Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry. Annals of Oncology, 27, pp. 159-165. (doi: 10.1093/annonc/mdv504)

Powles, T., Brown, J., Larkin, J., Jones, R., Ralph, C., Hawkins, R., Chowdhury, S., Boleti, E., Bhal, A., Fife, K., Webb, A., Crabb, S., Geldart, T., Hill, R., Dunlop, J., Hall, P. E., McLaren, D., Ackerman, C., Beltran, L., Nathan, P. (2016) A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK) Annals of Oncology, 27, pp. 880-886. (doi: 10.1093/annonc/mdw014)

James, N. D. et al. (2016) Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform-randomised controlled trial. Lancet, 387, pp. 1163-1177. (doi: 10.1016/S0140-6736(15)01037-5)

Fulton, B., Jones, R. J. (2016) Combination treatment strategies with docetaxel in patients with metastatic prostate. Springer

Cagan, R. (2016) Drug screening using model systems: some basics. Disease Models and Mechanisms, 9, pp. 1241-1244. (doi: 10.1242/dmm.028159)

Thambyrajah, R., Mazan, M., Patel, R., Moignard, V., Stefanska, M., Marinopoulou, E., Li, Y., Lancrin, C., Clapes, T., Möröy, T., Robin, C., Miller, C., Cowley, S., Göttgens, B., Kouskoff, V., Lacaud, G. (2016) GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology, 18, pp. 21-32. (doi: 10.1038/ncb3276)

Elbediwy, A., Vincent-Mistiaen, Z. I., Spencer-Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J., Tan, E. H., Ridgway, R., Brunton, V. G., Sahai, E., Gerhardt, H., Behrens, A., Malanchi, I., Sansom, O. J., Thompson, B. J. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143, pp. 1674-1687. (doi: 10.1242/dev.133728)

Rahat, M. A., Coffelt, S., Granot, Z., Muthana, M., Amedei, A. (2016) Macrophages and neutrophils: regulation of the inflammatory microenvironment in autoimmunity and cancer. Mediators of Inflammation, 2016, (doi: 10.1155/2016/5894347)

Park, J. H., Powell, A. G., Roxburgh, C. S.D., Horgan, P. G., McMillan, D. c., Edwards, J. (2016) Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment. British Journal of Cancer, 114, pp. 562-570. (doi: 10.1038/bjc.2016.17)

Roseweir, A. K., Qayyum, T., Lim, Z., Hammond, R., MacDonald, A. I., Fraser, S., Oades, G. M., Aitchison, M., Jones, R. J., Edwards, J. (2016) Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients. BMC Cancer, 16, pp. 229. (doi: 10.1186/s12885-016-2254-9)

Conteduca, V., Crabb, S. J., Jones, R. J., Caffo, O., Elliott, T., Scarpi, E., Fabbri, P., Derosa, L., Massari, F., Numico, G., Zarif, S., Hanna, C., Maines, F., Joyce, H., Lolli, C., De Giorgi, U. (2016) Persistent neutrophil to lymphocyte ratio >3 during treatment with enzalutamide and clinical outcome in patients with castration-resistant prostate cancer. PLoS ONE, 11, (doi: 10.1371/journal.pone.0158952)

Coffelt, S. B., de Visser, K. E. (2016) Systemic inflammation: Cancer's long-distance reach to maximize metastasis. OncoImmunology, 5, (doi: 10.1080/2162402X.2015.1075694)

McSorley, S. T., Horgan, P. G., McMillan, D. C. (2016) The impact of preoperative corticosteroids on the systemic inflammatory response and postoperative complications following surgery for gastrointestinal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 101, pp. 139-150. (doi: 10.1016/j.critrevonc.2016.03.011)

Carotenuto, P. et al. (2016) Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut, 66, pp. 1268-1277. (doi: 10.1136/gutjnl-2016-312278)