Brain/glioblastoma

We are part of the Scottish Brain Tumour Research Centre of Excellence, and research covers pre-clinical validation and modelling, new types of treatments and metastasis

Staff

Publications

2025

Rulach, R., Chalmers, A. (2025) Re-irradiation of recurrent lung tumours: Associations between dose and 2-year survival. Clinical and Translational Radiation Oncology,

May, S., Stevenson, K., Alqarafi, B., Yin Swe, K. L., Bloom, A., Mackintosh, A., Müller, M., Georgakopoulou, A., Drake, T. M., Kiourtis, C., Karim, S. A., Nixon, C., Cadden, B., Duffton, A., Grose, D., Lewis, D. Y., Blyth, K., Chalmers, A. J., Bird, T. G. (2025) A precision image-guided model of stereotactic ablative radiotherapy for hepatocellular carcinoma. Disease Models and Mechanisms, 18, (doi: 10.1242/dmm.052301)

Irving, A., Lammy, S., Alakandy, L. (2025) 38-year delayed spinal leptomeningeal dissemination of a paediatric pilocytic astrocytoma: a case report. Case Reports in Oncology, 18, pp. 702-710. (doi: 10.1159/000545935)

Pearson, L.-A., Petit, A.-P., Mendoza-Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P. K., Paul, M., Postis, V., Hu, X., Cowling, V. H., Gray, D. W. (2025) Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach. Biochemical Journal, 482, pp. 209-224. (doi: 10.1042/bcj20240608)

2024

Lammy, S., Brown, J. (2024) Neurosurgical Handovers and Standards for Emergency Care. Cambridge University Press

Werner, J.-M., Petrescu, G. E.D., Boele, F., Preusser, M., Platten, M., Chalmers, A. J., Short, S. C., Piil, K. (2024) Chairing scientific sessions at international Neuro-Oncology meetings: an EANO guide for early-career professionals. Neuro-Oncology Practice, 11, pp. 673-676. (doi: 10.1093/nop/npae060)

Williamson, A., Houston, P., Paterson, J., Chalmers, A. J., McLoone, P., Fullerton, N., Foo, S. Y., James, A., Nowicki, S. (2024) Dosimetric comparison of hippocampal sparing technologies in patients with low grade glioma. Neuro-Oncology Advances, 6, (doi: 10.1093/noajnl/vdae131)

Mactier, K., Baxter, M., Peters, A., Fair, K., Hannington, L., Robertson, J., Wood, G., Sarwar, A., Bishr, M., Webb, R., Al-Zubaidi, M., Eastlake, L., Lankester, K., McInerney, S., Creedon, H., Stillie, A., Purshouse, K. (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14, (doi: 10.1136/bmjopen-2024-094838)

Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)

Jackson, M. R., Richards, A. R., Oladipupo, A.-B. A., Chahal, S. K., Caragher, S., Chalmers, A. J., Gomez-Roman, N. (2024) ClonoScreen3D - a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma. International Journal of Radiation Oncology, Biology, Physics, 120, pp. 162-177. (doi: 10.1016/j.ijrobp.2024.02.046)

Lorimer, C., Mills, S., Chalmers, A., Coombes, I., Thompson, G., Glendenning, J., Radon, M., Jones, C., Williamson, A., Brock, J. (2024) Baseline total brain volume predicts changes in quality of life and overall survival after cranial radiotherapy in older patients with glioblastoma: Results from the prospective BRITER study. Neuro-Oncology Practice, 11, pp. 413-420. (doi: 10.1093/nop/npae019)

Boele, F., Rosenlund, L., Nordentoft, S., Melhuish, S., Nicklin, E., Rydén, I., Williamson, A., Donders-Kamphuis, M., Preusser, M., Le Rhun, E., Kiesel, B., Minniti, G., Furtner, J., Dirven, L., Taphoorn, M., Galldiks, N., Rudà, R., Chalmers, A., Short, S. C., Piil, K., the Nurse and Allied Health Professionals Committee, , the Disparity and Inclusion Committee of EANO, (2024) Inequalities in access to neuro-oncology supportive care and rehabilitation: a survey of healthcare professionals’ perspectives. Neuro-Oncology Practice, 11, pp. 484-493. (doi: 10.1093/nop/npae023)

Lukoszek, R., Inesta-Vaquera, F., Brett, N. J.M., Liang, S., Hepburn, L. A., Hughes, D. J., Pirillo, C., Roberts, E. W., Cowling, V. H. (2024) CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.114405)

NIHR Global Health Research Unit on Global Surgery, , STARSurg Collaborative, , , (2024) A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts. Lancet Digital Health, 6, pp. e507-e519. (doi: 10.1016/s2589-7500(24)00065-7)

Thapa, A., Cowell, A., Peters, A., Noble, D. J., James, A., Lamb, C., Grose, D., Vohra, S., Schipani, S., Mactier, K., Mackenzie, J., Srinivasan, D., Laws, K., Moleron, R., Niblock, P., Soh, F.-Y., Paterson, C., Wilson, C. (2024) The UK Divide: Does having a Pembrolizumab-Chemotherapy option in head and neck cancer matter? Real-world experience of first-line palliative pembrolizumab monotherapy and pembrolizumab-chemotherapy combination in Scotland. Clinical Oncology, 36, pp. 287-299. (doi: 10.1016/j.clon.2024.02.004)

Vens, C., van Luijk, P., Vogelius, R.I., El Naqa, I., Humbert-Vidan, L., von Neubeck, C., Gomez-Roman, N., Bahn, E., Brualla, L., Böhlen, T.T., Ecker, S., Koch, R., Handeland, A., Pereira, S., Possenti, L., Rancati, T., Todor, D., Vanderstraeten, B., Van Heerden, M., Ullrich, W., Jackson, M., Alber, M., Marignol, L., ESTRO DREAM team, (2024) A joint physics and radiobiology DREAM team vision - towards better response prediction models to advance radiotherapy. Radiotherapy and Oncology, 196, (doi: 10.1016/j.radonc.2024.110277)

Pennel, K., Dutton, L., Melissourgou-Syka, L., Roxburgh, C., Birch, J., Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, (doi: 10.1017/erm.2024.15)

Ahmadian, M., Bodalal, Z., van der Hulst, H. J., Vens, C., Karssemakers, L. H.E., Bogveradze, N., Castagnoli, F., Landolfi, F., Hong, E. K., Gennaro, N., Pizzi, A. D., Beets-Tan, R. G.H., van den Brekel, M. W.M., Castelijns, J. A. (2024) Overcoming data scarcity in radiomics/radiogenomics using synthetic radiomic features. Computers in Biology and Medicine, 174, (doi: 10.1016/j.compbiomed.2024.108389)

Derby, S., Jackson, M. R., Williams, K., Stobo, J., Kelly, C., Sweeting, L., Shad, S., Herbert, C., Short, S. C., Williamson, A., James, A., Nowicki, S., Bulbeck, H., Chalmers, A. (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118, pp. 1371-1378. (doi: 10.1016/j.ijrobp.2024.01.011)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26, pp. 625-639. (doi: 10.1093/neuonc/noad210)

Wakeham, K., Cooper, T., Rowbottom, C., Chalmers, A. J., Price, P., Quinlan, S., Spencer, K. (2024) Towards world-class radiotherapy in the UK: time for transformation. Lancet Oncology, 25, pp. 418-419. (doi: 10.1016/S1470-2045(24)00103-7)

Derby, S., Jackson, M. R., Williams, K., Stobo, J., Kelly, C., Sweeting, L., Shad, S., Herbert, C., Short, S. C., Williamson, A., James, A., Nowicki, S., Bulbeck, H., Chalmers, A. J. (2024) Concurrent olaparib and radiation therapy in older patients with newly diagnosed glioblastoma: the phase 1 dose-escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118, pp. 1371-1378. (doi: 10.1016/j.ijrobp.2024.01.011)

Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J., Sansom, O. J., O'Neill, E., Jones, K., Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050463)

Harris, B. H. L., McCabe, C., Shafique, H., Lammy, S., Tookman, L., Flanagan, J., Miron-Barroso, S., Lythgoe, M., Clark, J., Walsh, J. L., Di Giovannantonio, M., Krell, J. (2024) Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK. Journal of Human Genetics, 69, pp. 19-25. (doi: 10.1038/s10038-023-01199-1)

Knop, K., Gomez-Moreira, C., Galloway, A., Ditsova, D., Cowling, V. H. (2024) RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression. Discovery Immunology, 3, (doi: 10.1093/discim/kyad021)

2023

Lammy, S., McPartlin, R., Bridgman, E., Bouttell, J., Brown, J. (2023) Usefulness of preoperative extracranial imaging in radiologically suspicious glioblastoma in the West of Scotland and proposal of an imaging diagnostic pathway. Annals of the Royal College of Surgeons of England, 105, pp. 754-764. (doi: 10.1308/rcsann.2022.0106)

Van der Hulst, H. J., Jansen, R. W., Vens, C., Bos, P., Schats, W., De Jong, M. C., Martens, R. M., Bodalal, Z., Beets-Tan, R. G. H., Van den Brekel, M. W. M., De Graaf, P., Castelijns, J. A. (2023) The prediction of biological features using magnetic resonance imaging in head and neck squamous cell carcinoma: a systematic review and meta-analysis. Cancers, 15, (doi: 10.3390/cancers15205077)

Hoeritzauer, I., Paterson, M., Jamjoom, A., Srikandarajah, N., Soleiman, H., Poon, M. T. C., Copley, P. C., Graves, C., MacKay, S., Duong, C., Leung, A. H.C., Eames, N., Statham, P. F. X., Darwish, S., Sell, P. J., Thorpe, P., Shekhar, H., Roy, H., Woodfield, J., British Neurosurgical Trainee Research Collaborative, (2023) Cauda equina syndrome: poor inter-rater agreement for diagnostic categories. Bone and Joint Journal, 105-B, pp. 1007-1012. (doi: 10.1302/0301-620x.105b9.bjj-2022-1343.r1)

Kouli, O. O., McLoone, P., Morrison, D., Zaorsky, N. G., Chalmers, A. J. (2023) Risk of stroke-specific mortality after radiotherapy in patients with primary brain tumours. Clinical and Translational Radiation Oncology, 42, (doi: 10.1016/j.ctro.2023.100658)

Poon, M. T. C. et al. (2023) Variation in postoperative outcomes of patients with intracranial tumors: insights from a prospective international cohort study during the COVID-19 pandemic. Neuro-Oncology, 25, pp. 1299-1309. (doi: 10.1093/neuonc/noad019)

Loan, J. J. M. et al. (2023) Prospective, multicentre study of screening, investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland. Stroke and Vascular Neurology, 8, (doi: 10.1136/svn-2022-001583)

Liang, S., Almohammed, R., Cowling, V. H. (2023) The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation. Biochemical Society Transactions, 51, pp. 1131-1141. (doi: 10.1042/BST20221154)

CholeS. Study Group, W. M. R. C., , (2023) Correction: The Cholecystectomy As A Day Case (CAAD) Score: A validated score of preoperative predictors of successful day-case cholecystectomy using the CholeS data set. World Journal of Surgery, 47, pp. 1082. (doi: 10.1007/s00268-023-06911-y)

Woodfield, J., Hoeritzauer, I., Jamjoom, A. A.B., Lammy, S., Pronin, S., Hannan, C. J., Watts, A., Hughes, L., Moon, R. D.C., Roy, H., Poon, M. T.C., Thorpe, P., Srikandarajah, N., Demetriades, A. K., Eames, N., Sell, P. J., Statham, P. F.X. (2023) More questions than answers to the diagnosis and management of cauda equina syndrome—authors’ reply. Lancet Regional Health - Europe, 27, (doi: 10.1016/j.lanepe.2023.100606)

Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H.J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C.G.G., Staut, N., Subiel, A., Vaes, R. D.W., van Hoof, S. J., Verginadis, I. L., Wilkens, J. J., Williams, K. J., Wilson, G. D., Dubois, L. J. (2023) Roadmap for precision preclinical x-ray radiation studies. Physics in Medicine and Biology, 68, (doi: 10.1088/1361-6560/acaf45)

Lammy, S., Brown, J., Littlechild, P. (2023) Cavernous sinus haemangioma masquerading as a pituitary macroadenoma: how the unexpected lurks in neurosurgery. British Journal of Neurosurgery, 37, pp. 234-236. (doi: 10.1080/02688697.2020.1861437)

Lammy, S., Piper, R., Mukerji, N. (2023) Fellowship of the British Journal of Neurosurgery. British Journal of Neurosurgery, 37, pp. 125-126. (doi: 10.1080/02688697.2023.2173873)

Woodfield, J., Lammy, S., Jamjoom, A. A.B., Fadelalla, M. A.G., Copley, P. C., Arora, M., Glasmacher, S. A., Abdelsadg, M., Scicluna, G., Poon, M. T.C., Pronin, S., Leung, A. H.C., Darwish, S., Demetriades, A. K., Brown, J., Eames, N., Statham, P. F.X., Hoeritzauer, I., UCES Study Collaborators, , British Neurosurgical Trainee Research Collaborative, (2023) Demographics of cauda equina syndrome: a population based incidence study. Neuroepidemiology, 56, pp. 460-468. (doi: 10.1159/000527727)

Grocutt, L., Rutherford, A., Caldwell, D., Wilkinson, C., Chalmers, A.J., Dempsey, L., Kelly, C., O'Cathail, S.M. (2023) The impact of COVID-19 on radiotherapy services in Scotland, UK: a population-based study. Clinical Oncology, 35, pp. e227-e234. (doi: 10.1016/j.clon.2022.11.018)

Koessinger, D., Novo, D., Koessinger, A., Campos, A., Peters, J., Dutton, L., Paschke, P., Zerbst, D., Moore, M., Mitchell, L., Neilson, M., Stevenson, K., Chalmers, A., Tait, S., Birch, J., Norman, J. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5, (doi: 10.1093/noajnl/vdad067)

Woodfield, J., Hoeritzauer, I., Jamjoom, A. A.B., Jung, J., Lammy, S., Pronin, S., Hannan, C. J., Watts, A., Hughes, L., Moon, R. D.C., Darwish, S., Roy, H., Copley, P. C., Poon, M. T.C., Thorpe, P., Srikandarajah, N., Grahovac, G., Demetriades, A. K., Eames, N., Sell, P. J., Statham, P. F. X., UCES Collaborators, ., British Neurosurgical Trainee Research Collaborative, . (2023) Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study. Lancet Regional Health - Europe, 24, (doi: 10.1016/j.lanepe.2022.100545)

2022

O'Cathail, S.M., Chalmers, A.J. (2022) Integrating novel cancer therapies with radiation - illuminating the tunnel. Clinical Oncology, 35, pp. 38-41. (doi: 10.1016/j.clon.2022.10.010)

Elsheikh, M., Bridgman, E., Lavrador, J. P., Lammy, S., Poon, M. T. C. (2022) Association of extent of resection and functional outcomes in diffuse low-grade glioma: systematic review & meta-analysis. Journal of Neuro-Oncology, 160, pp. 717-724. (doi: 10.1007/s11060-022-04192-4)

Turner, M., Murchie, P., Derby, S., Ong, A. Y., Walji, L., McLernon, D., Macleod, M.-J., Adam, R. (2022) Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis. Journal of Cancer Survivorship, 16, pp. 1414-1448. (doi: 10.1007/s11764-021-01122-7)

Falcone, M., Huerta Uribe, A., Papalazarou, V., Newman, A. C., Athineos, D., Stevenson, K., Sauvé, C.-E. G., Gao, Y., Kim, J. K., Del Latto, M., Kierstead, M., Wu, C., Smith, J. J., Romesser, P. B., Chalmers, A. J., Blyth, K., Maddocks, O. D.K. (2022) Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. British Journal of Cancer, 127, pp. 1773-1786. (doi: 10.1038/s41416-022-01965-6)

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29, pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3)

van der Wiel, A. M. A., Schuitmaker, L., Cong, Y., Theys, J., Van Hoeck, A., Vens, C., Lambin, P., Yaromina, A., Dubois, L. J. (2022) Homologous recombination deficiency scar: mutations and beyond—implications for precision oncology. Cancers, 14, (doi: 10.3390/cancers14174157)

Gillespie, C. S., Bligh, E. R., Poon, M. T.C., Solomou, G., Islim, A. I., Mustafa, M. A., Rominiyi, O., Williams, S. T., Kalra, N., Mathew, R. K., Booth, T. C., Thompson, G., Brennan, P. M., Jenkinson, M. D., INTERVAL-GB Collaborative, (2022) Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study. BMJ Open, 12, (doi: 10.1136/bmjopen-2022-063043)

McKinley, A., Lammy, S., James, A., Stan, A., Barrett, C. (2022) Emergency surgical decompression and long term survival of glioblastoma presenting in coma in old age: case report and review of prognostic factors. Oxford Medical Case Reports, 2022, pp. 271-273. (doi: 10.1093/omcr/omac074)

McAleavey, P. G., Walls, G. M., Chalmers, A. J. (2022) Radiotherapy-drug combinations in the treatment of glioblastoma: a brief review. CNS Oncology, 11, (doi: 10.2217/cns-2021-0015)

Zhang, Y., McGowan Holloway, S., Zoë Wilson, M., Alshaikhi, J., Tan, W., Royle, G., Bär, E. (2022) DIR-based models to predict weekly anatomical changes in head and neck cancer proton therapy. Physics in Medicine and Biology, 67, (doi: 10.1088/1361-6560/ac5fe2)

May, G., Lammy, S., Kumar, A., Hegde, A., St. George, E. J. (2022) First reported case of hydrocephalus in jointly diagnosed bacterial meningitis and a colloid cyst: how Ockham’s razor became Hickam’s dictum. British Journal of Neurosurgery, 36, pp. 420-423. (doi: 10.1080/02688697.2022.2077911)

Willers, H., Krause, M., Faivre-Finn, C., Chalmers, A. (2022) Targeting PARP for chemoradiosensitization: opportunities, challenges, and the road ahead. International Journal of Radiation Oncology, Biology, Physics, 112, pp. 265-270. (doi: 10.1016/j.ijrobp.2021.10.142)

Jackson, M. R., Stevenson, K., Chahal, S. K., Curley, E., Finney, G. E., Gutierrez-Quintana, R., Onwubiko, E., Rupp, A., Strathdee, K., Williams, K., MacLeod, M. K.L., McSharry, C., Chalmers, A. J. (2022) Low-dose lung radiotherapy for COVID-19 lung disease: a preclinical efficacy study in a bleomycin model of pneumonitis. International Journal of Radiation Oncology, Biology, Physics, 112, pp. 197-211. (doi: 10.1016/j.ijrobp.2021.08.029)

Aiyappa-Maudsley, R., Chalmers, A. J., Parsons, J. L. (2022) Factors affecting the radiation response in glioblastoma. Neuro-Oncology Advances, 4, (doi: 10.1093/noajnl/vdac156)

Gutierrez-Quintana, R., Walker, D. J., Williams, K. J., Forster, D. M., Chalmers, A. J. (2022) Radiation-induced neuroinflammation: a potential protective role for poly(ADP-ribose) polymerase inhibitors? Neuro-Oncology Advances, 4, (doi: 10.1093/noajnl/vdab190)

Derby, S. J., Chalmers, A. J., Carruthers, R. (2022) Radiotherapy-poly(ADP-ribose) polymerase inhibitor combinations: progress to date. Seminars in Radiation Oncology, 32, pp. 15-28. (doi: 10.1016/j.semradonc.2021.09.005)

2021

COVIDSurg Collaborative, , GlobalSurg Collaborative, (2021) SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia, 77, pp. 28-39. (doi: 10.1111/anae.15563)

COVIDSurg Collaborative, (2021) Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. Lancet Oncology, 22, pp. 1507-1517. (doi: 10.1016/s1470-2045(21)00493-9)

COVIDSurg Collaborative, , GlobalSurg Collaborative, (2021) Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia, 76, pp. 1454-1464. (doi: 10.1111/anae.15560)

COVIDSurg Collaborative, (2021) Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. British Journal of Surgery, 108, pp. 1274-1292. (doi: 10.1093/bjs/znab183)

Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16, pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018)

Fountain, D.M. et al. (2021) First report of a multicenter prospective registry of cranioplasty in the United Kingdom and Ireland. Neurosurgery, 89, pp. 518-526. (doi: 10.1093/neuros/nyab220)

COVIDSurg Collaborative, , GlobalSurg Collaborative, (2021) SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. British Journal of Surgery, 108, pp. 1056-1063. (doi: 10.1093/bjs/znab101)

Derby, S., Wallace, J., Venugopal, B., Garcia, A. C. (2021) Advanced penile cancer presenting with renal failure. Oncology, 35, pp. 425-428. (doi: 10.46883/onc.2021.3507.0425)

Bradley, R., Bremner, M., McKinley, A., Lammy, S. (2021) Usefulness of Royal College of Surgeons of England operation note guidelines to neurosurgical practice: a closed loop audit. British Journal of Neurosurgery, 35, pp. 418-423. (doi: 10.1080/02688697.2020.1817858)

Koessinger, A. L., Koessinger, D., Kinch, K., Martínez-Escardó, L., Paul, N. R., Elmasry, Y., Malviya, G., Cloix, C., Campbell, K. J., Bock, F. J., O'Prey, J., Stevenson, K., Nixon, C., Jackson, M. R., Ichim, G., Stewart, W., Blyth, K., Ryan, K. M., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)

COVIDSurg Collaborative, , GlobalSurg Collaborative, (2021) Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. Anaesthesia, 76, pp. 748-758. (doi: 10.1111/anae.15458)

Nile, D. L., Rae, C., Walker, D. J., Canning Waddington, J., Vincent, I., Burgess, K., Gaze, M. N., Mairs, R. J., Chalmers, A. J. (2021) Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells. Cancer and Metabolism, 9, (doi: 10.1186/s40170-021-00258-5)

Chalmers, A.J., Carruthers, R.D. (2021) Radiobiology summaries: DNA damage and repair. Clinical Oncology, 33, pp. 275-278. (doi: 10.1016/j.clon.2020.12.006)

Piper, R. J., Afshari, F. T., Soon, W. C., Kolias, A. G., Dyson, E. W., Watkins, L., Laing, R., Lo, W. B., Jayamohan, J., the British Neurosurgical Trainee Research Collaborative (BNTRC), (2021) UK Chiari 1 Study: protocol for a prospective, observational, multicentre study. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-043712)

Hanna, C. R., Robb, K. A., Blyth, K. G., Jones, R. J., Chalmers, A. J. (2021) Clinician attitudes to using low dose radiotherapy to treat COVID-19 lung disease. International Journal of Radiation Oncology, Biology, Physics, 109, pp. 886-890. (doi: 10.1016/j.ijrobp.2020.12.003)

Rulach, R., Ball, D., Chua, K., Dahele, M., De Ruysscher, D., Franks, K., Gomez, D., Guckenberger, M., Hanna, G., Louie, A., Moghanaki, D., Palma, D., Peedell, C., Salem, A., Silva, S., Videtic, G., Chalmers, A., Harrow, S. (2021) An international expert survey on the indications and practice of radical thoracic reirradiation for non-small cell lung cancer. Advances in Radiation Oncology, 6, (doi: 10.1016/j.adro.2021.100653)

Liu, Q., Palomero, L., Moore, J., Guiz, I., Espín, R., Aytés, A., Mao, J.-H., Paulovich, A. G., Whiteaker, J. R., Ivey, R. G., Iliakis, G., Luo, D., Chalmers, A. J., Murnane, J., Pujana, M. A., Barcellos-Hoff, M. H. (2021) Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Science Translational Medicine, 13, (doi: 10.1126/scitranslmed.abc4465)

Kanani, M., Lammy, S. (2021) Surgical Critical Care For the MRCS OSCE. Cambridge University Press

Al-mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Chalmers, A.J., Holmes, W.M. (2021) Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of glioblastoma. Magnetic resonance imaging, 85, pp. 121-127. (doi: 10.1016/j.mri.2021.10.030)

Hadjiyiannakis, D., Dimitroyannis, D., Eastlake, L., Peedell, C., Tripathi, L., Simcock, R., Vyas, A., Deutsch, E., Chalmers, A.J. (2021) Personal view: low-dose lung radiotherapy should be evaluated as a treatment for severe COVID-19 lung disease. Clinical Oncology, 33, pp. e64-e68. (doi: 10.1016/j.clon.2020.08.003)

Derby, S., Forshaw, M., Lowrie, C., Grose, D., Marashi, H., McLoone, P., Wilson, C., McIntosh, D. (2021) Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus. BMJ Open Gastroenterology, 8, (doi: 10.1136/bmjgast-2020-000492)

2020

Hanna, C., Kurian, K. M., Williams, K., Watts, C., Jackson, A., Carruthers, R., Strathdee, K., Cruickshank, G., Dunn, L., Erridge, S., Godfrey, L., Jefferies, S., McBain, C., Sleigh, R., McCormick, A., Pittman, M., Halford, S., Chalmers, A. J. (2020) Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial. Neuro-Oncology, 22, pp. 1840-1850. (doi: 10.1093/neuonc/noaa104)

Lammy, S., Taylor, A., Willetts, S., St George, E. J. (2020) Fifteen-year institutional retrospective case series of decompressive craniectomy for malignant middle cerebral artery infarction. World Neurosurgery, 143, pp. e456-e463. (doi: 10.1016/j.wneu.2020.07.185)

Lammy, S., Taylor, A., Willetts, S., St George, E. J. (2020) In reply to the letter to the editor regarding “15-Year Institutional Retrospective Case Series of Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction (mMCAI)” World Neurosurgery, 143, pp. 640. (doi: 10.1016/j.wneu.2020.08.155)

Lammy, S. (2020) Management of traumatic brain injury in China versus Europe. Lancet Neurology, 19, pp. 886. (doi: 10.1016/S1474-4422(20)30345-8)

Lee, L. Y. W. et al. (2020) COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study. Lancet Oncology, 21, pp. 1309-1316. (doi: 10.1016/s1470-2045(20)30442-3)

Nassar, A.H.M. et al. (2020) Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system. Surgical Endoscopy, 34, pp. 4549-4561. (doi: 10.1007/s00464-019-07244-5)

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, (doi: 10.1038/s41598-020-72322-x)

Rae, C., Fragkoulis, G. I., Chalmers, A. J. (2020) Cytotoxicity and radiosensitizing activity of the fatty acid synthase inhibitor C75 is enhanced by blocking fatty acid uptake in prostate cancer cells. Advances in Radiation Oncology, 5, pp. 944-1005. (doi: 10.1016/j.adro.2020.06.022)

Vergani, F. et al. (2020) Management evaluation of metastasis in the brain (MEMBRAIN)—a United Kingdom and Ireland prospective, multicenter observational study. Neuro-Oncology Practice, 7, pp. 344-355. (doi: 10.1093/nop/npz063)

Litchfield, K. et al. (2020) Representative sequencing: unbiased sampling of solid tumor tissue. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107550)

Jackson, M. R., Ashton, M., Koessinger, A. L., Dick, C., Verheij, M., Chalmers, A. J. (2020) Mesothelioma cells depend on the anti-apoptotic protein Bcl-xL for survival and are sensitized to ionizing radiation by BH3-mimetics. International Journal of Radiation Oncology, Biology, Physics, 106, pp. 867-877. (doi: 10.1016/j.ijrobp.2019.11.029)

Gomez-Roman, N., Chong, M. Y., Chahal, S. K., Caragher, S. P., Jackson, M. R., Stevenson, K. H., Dongre, S. A., Chalmers, A. J. (2020) Radiation responses of 2D and 3D glioblastoma cells: a novel, 3D-specific radioprotective role of VEGF/Akt signaling through functional activation of NHEJ. Molecular Cancer Therapeutics, 19, pp. 575-589. (doi: 10.1158/1535-7163.MCT-18-1320)

Chalmers, A.J., Chan, C., Sebag-Montefiore, D. (2020) CTRad 10 years on: from 10-point plan to top 10 achievements. Clinical Oncology, 32, pp. 9-12. (doi: 10.1016/j.clon.2019.09.043)

2019

Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P., Chalmers, A. J. (2019) An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment? CNS Oncology, 8, (doi: 10.2217/cns-2019-0017)

Beckta, J. M., Bindra, R. S., Chalmers, A. J. (2019) Targeting DNA repair in gliomas. Current Opinion in Neurology, 32, pp. 878-885. (doi: 10.1097/WCO.0000000000000760)

Al-Mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Gilmour, L., Foster, J., Chalmers, A.J., Holmes, W.M. (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: application to an infiltrative brain tumour model. Journal of Neuroscience Methods, 326, (doi: 10.1016/j.jneumeth.2019.108372)

Venkataramani, V. et al. (2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature, 573, pp. 532-538. (doi: 10.1038/s41586-019-1564-x)

Derby, S., Graham, J., McIntosh, D. (2019) An unusual cause of paraesthesia in a neo-adjuvant gastro-oesophageal cancer. BMJ Case Reports, 12, (doi: 10.1136/bcr-2018-225450)

Palma, D. A. et al. (2019) Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial. BMC Cancer, 19, (doi: 10.1186/s12885-019-5977-6)

El-Sharkawy, A.M. et al. (2019) The Cholecystectomy As A Day Case (CAAD) score: a validated score of preoperative predictors of successful day-case cholecystectomy using the CholeS data set. World Journal of Surgery, 43, pp. 1928-1934. (doi: 10.1007/s00268-019-04981-5)

Vallatos, A., Al-Mubarak, H.F.I., Birch, J.L., Gallagher, L., Mullin, J.M., Gilmour, L., Holmes, W.M., Chalmers, A.J. (2019) Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. Journal of Magnetic Resonance Imaging, 50, pp. 529-540. (doi: 10.1002/jmri.26580)

Kokurewicz, K., Brunetti, E., Welsh, G.H., Wiggins, S.M., Boyd, M., Sorensen, A., Chalmers, A.J., Schettino, G., Subiel, A., DesRosiers, C., Jaroszynski, D.A. (2019) Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. Scientific Reports, 9, (doi: 10.1038/s41598-019-46630-w)

Gomez-Roman, N., Chalmers, A. J. (2019) Patient-specific 3D-printed glioblastomas. Nature Biomedical Engineering, 3, pp. 498-499. (doi: 10.1038/s41551-019-0379-2)

Poorthuis, M. H.F., Rinkel, L. A., Lammy, S., Al-Shahi Salman, R. (2019) Stereotactic radiosurgery for cerebral cavernous malformations: a systematic review. Neurology, 93, pp. e1971-e1979. (doi: 10.1212/WNL.0000000000008521)

Gobin, M., Nazarov, P. V., Warta, R., Timmer, M., Reifenberger, G., Felsberg, J., Vallar, L., Chalmers, A. J., Herold-Mende, C. C., Goldbrunner, R., Niclou, S. P., Van Dyck, E. (2019) A DNA repair and cell cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications. Cancer Research, 79, pp. 1226-1238. (doi: 10.1158/0008-5472.CAN-18-2076)

Caragher, S., Chalmers, A. J., Gomez-Roman, M. (2019) Glioblastoma's next top model: novel culture systems for brain cancer radiotherapy research. Cancers, 11, (doi: 10.3390/cancers11010044)

Rutherford, A., Stevenson, K., Tulk, A., Chalmers, A. J. (2019) Evaluation of four different small animal radiation plans on tumour and normal tissue dosimetry in a glioblastoma mouse model. British Journal of Radiology, 92, (doi: 10.1259/bjr.20180469)

2018

Birch, J. L., Strathdee, K., Gilmour, L., Vallatos, A., McDonald, L., Kouzeli, A., Vasan, R., Qaisi, A. H., Croft, D. R., Crighton, D., Gill, K., Gray, C. H., Konczal, J., Mezna, M., McArthur, D., Schüttelkopf, A. W., McConnell, P., Sime, M., Holmes, W. M., Bower, J., McKinnon, H. J., Drysdale, M., Olson, M. F., Chalmers, A. J. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78, pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697)

Sharma, R. A. et al. (2018) Clinical development of new drug–radiotherapy combinations. Nature Reviews Clinical Oncology, 13, pp. 627-642. (doi: 10.1038/nrclinonc.2016.79)

Carruthers, R. D., Ahmed, S. U., Ramachandran, S., Strathdee, K., Kurian, K. M., Hedley, A., Gomez-Roman, N., Kalna, G., Neilson, M. P., Gilmour, L., Stevenson, K. H., Hammond, E. M., Chalmers, A. J. (2018) Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research, 78, pp. 5060-5071. (doi: 10.1158/0008-5472.CAN-18-0569)

Martinez-Zubiaurre, I., Chalmers, A. J., Hellevik, T. (2018) Radiation-induced transformation of immunoregulatory networks in the tumor stroma. Frontiers in Immunology, 9, (doi: 10.3389/fimmu.2018.01679)

Bharamgoudar, R. et al. (2018) The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy. Surgical Endoscopy, 32, pp. 3149-3157. (doi: 10.1007/s00464-018-6030-6)

Martin, G. A., Tsim, S., Kidd, A. C., Foster, J. E., McLoone, P., Chalmers, A., Blyth, K. G. (2018) Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2018-000293)

Zmuda, F., Blair, A., Liuzzi, M. C., Malviya, G., Chalmers, A. J., Lewis, D., Sutherland, A., Pimlott, S. L. (2018) An 18F-labeled poly(ADP-ribose) polymerase positron emission tomography imaging agent. Journal of Medicinal Chemistry, 61, pp. 4103-4114. (doi: 10.1021/acs.jmedchem.8b00138)

Gray, E., Butler, H. J., Board, R., Brennan, P. M., Chalmers, A. J., Dawson, T., Goodden, J., Hamilton, W., Hegarty, M. G., James, A., Jenkinson, M. D., Kernick, D., Lekka, E., Livermore, L. J., Mills, S. J., O’Neill, K., Palmer, D. S., Vaqas, B., Baker, M. J. (2018) Health economic evaluation of a serum-based blood test for brain tumour diagnosis: exploration of two clinical scenarios. BMJ Open, 8, (doi: 10.1136/bmjopen-2017-017593)

Holmes, W. M., Vallatos, A., Gilmour, L., Chalmers, A. J. (2018) Multiple boli arterial spin labelling for high signal-to-noise rodent brain perfusion imaging. Magnetic Resonance in Medicine, 79, pp. 1020-1030. (doi: 10.1002/mrm.26706)

Fulton, B., Short, S. C., James, A., Nowicki, S., McBain, C., Jefferies, S., Kelly, C., Stobo, J., Morris, A., Williamson, A., Chalmers, A. (2018) PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT status. Clinical and Translational Radiation Oncology, 8, pp. 12-16. (doi: 10.1016/j.ctro.2017.11.003)

Ashton, M., O'Rourke, N., Macleod, N., Laird, B., Stobo, J., Kelly, C., Alexander, L., Franks, K., Moore, K., Currie, S., Valentine, R., Chalmers, A.J. (2018) SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma. Clinical and Translational Radiation Oncology, 8, pp. 45-49. (doi: 10.1016/j.ctro.2017.11.004)

Thompson, M. K., Poortmans, P., Chalmers, A. J., Faivre-Finn, C., Hall, E., Huddart, R. A., Lievens, Y., Sebag-Montefiore, D., Coles, C. E. (2018) Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie? British Journal of Cancer, 119, pp. 389-407. (doi: 10.1038/s41416-018-0201-z)

Lammy, S., Bhattacharya, J., Dervin, J., St. George, E. J. (2018) Trans-cranial embolisation of a complex transverse sigmoid sinus dural arteriovenous fistula by direct puncture of the superior sagittal sinus. Asian Journal of Neurosurgery, 13, pp. 946-948. (doi: 10.4103/ajns.AJNS_330_16)

2017

Lorimer, C.F., Hanna, C., Saran, F., Chalmers, A., Brock, J. (2017) Challenges to treating older glioblastoma patients: the influence of clinical and tumour characteristics on survival outcomes. Clinical Oncology, 29, pp. 739-747. (doi: 10.1016/j.clon.2017.05.010)

Ashton, M., O'Rourke, N., Currie, S., Rimner, A., Chalmers, A. (2017) The role of radical radiotherapy in the management of malignant pleural mesothelioma: a systematic review. Radiotherapy and Oncology, 125, pp. 1-12. (doi: 10.1016/j.radonc.2017.08.003)

Bindra, R. S., Chalmers, A. J., Evans, S., Dewhirst, M. (2017) GBM radiosensitizers: dead in the water…or just the beginning? Journal of Neuro-Oncology, 134, pp. 513-521. (doi: 10.1007/s11060-017-2427-7)

Gomez-Roman, N., Stevenson, K., Gilmour, L., Hamilton, G., Chalmers, A. (2017) A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses. Neuro-Oncology, 19, pp. 229-241. (doi: 10.1093/neuonc/now164)

Paterson, C., Allwood-Spiers, S., McCrea, I., Foster, J., McJury, M., Thomson, M., Sankaralingam, M., Grose, D., James, A., Rizwanullah, M., McLoone, P., Chalmers, A., Duffton, A. (2017) Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study. Clinical and Translational Radiation Oncology, 2, pp. 13-18. (doi: 10.1016/j.ctro.2016.12.003)

Sutton, A.J. et al. (2017) Cost-effectiveness of emergency versus delayed laparoscopic cholecystectomy for acute gallbladder pathology. British Journal of Surgery, 104, pp. 98-107. (doi: 10.1002/bjs.10317)

Carruthers, R., Chalmers, A. J. (2017) Improving the therapeutic ratio of radiotherapy by targeting the DNA damage response. Humana Press

2016

Lammy, S., Fivey, P., Sangra, M. (2016) Decompressive craniectomy for malignant middle cerebral artery infarction in a 16-year old boy: a case report. Journal of Medical Case Reports, 10, (doi: 10.1186/s13256-016-1145-7)

Kaur, A., Denisova, O., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, S. U., Raheem, O., Haapasalo, H. K., Eriksson, J., Chalmers, A. J., Laakkonen, P. M., Westermarck, J. (2016) PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Research, 76, pp. 7001-7011. (doi: 10.1158/0008-5472.CAN-16-1134)

Lammy, S., Al-Romhain, B., Osborne, L., St. George, E. J. (2016) 10-year institutional retrospective case series of decompressive craniectomy for malignant middle cerebral artery infarction (mMCAI) World Neurosurgery, 96, pp. 383-389. (doi: 10.1016/j.wneu.2016.09.004)

Tsim, S., Kelly, C., Alexander, L., McCormick, C., Thomson, F., Woodward, R., Foster, J. E., Stobo, D. B., Paul, J., Maskell, N. A., Chalmers, A., Blyth, K. G. (2016) Diagnostic and prognostic biomarkers in the rational assessment of mesothelioma (DIAPHRAGM) study: protocol of a prospective, multi-centre, observational study. BMJ Open, 6, (doi: 10.1136/bmjopen-2016-013324)

Lorimer, C. F., Saran, F., Chalmers, A. J., Brock, J. (2016) Glioblastoma in the elderly - how do we choose who to treat? Journal of Geriatric Oncology, 7, pp. 453-456. (doi: 10.1016/j.jgo.2016.07.005)

Vohra, R.S. et al. (2016) Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases. British Journal of Surgery, 103, pp. 1704-1715. (doi: 10.1002/bjs.10287)

Vohra, R.S. et al. (2016) Population-based cohort study of variation in the use of emergency cholecystectomy for benign gallbladder diseases. British Journal of Surgery, 103, pp. 1716-1726. (doi: 10.1002/bjs.10288)

Sutcliffe, R. et al. (2016) Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients. HPB, 18, pp. 922-928. (doi: 10.1016/j.hpb.2016.07.015)

Harrow, S., Hanna, G.G., Faivre-Finn, C., McDonald, F., Chalmers, A. (2016) The challenges faced in developing novel drug radiation combinations in non-small cell lung cancer. Clinical Oncology, 28, pp. 720-725. (doi: 10.1016/j.clon.2016.08.004)

Birch, J., Clarke, C., Campbell, A. D., Campbell, K., Mitchell, L., Liko, D., Kalna, G., Strathdee, D., Sansom, O. J., Neilson, M., Blyth, K., Norman, J. C. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5, pp. 1371-1379. (doi: 10.1242/bio.019075)

Lammy, S., Blackmur, J. P., Perkins, J. M.T. (2016) Intravenous heparin during ruptured abdominal aortic aneurysmal repair. Cochrane Database of Systematic Reviews, 2016, (doi: 10.1002/14651858.CD011486.pub2)

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M.O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B.P., Theys, J., Short, S. C., Verhaegen, F., Vooijs, M. (2016) NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. Oncotarget, 7, pp. 41251-41264. (doi: 10.18632/oncotarget.9275)

Chalmers, A. J. (2016) Science in focus: combining radiotherapy with inhibitors of the DNA damage response. Clinical Oncology, 28, pp. 279-282. (doi: 10.1016/j.clon.2016.01.035)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26, pp. 755-765. (doi: 10.1016/j.cub.2016.01.045)

Gomez-Roman, N., McGregor, F., Chalmers, A. J., Plumb, J. (2016) Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget, 7, (doi: 10.18632/oncotarget.7998)

Niyazi, M., Brada, M., Chalmers, A. J., Combs, S. E., Erridge, S. C., Fiorentino, A., Grosu, A. L., Lagerwaard, F. J., Minniti, G., Mirimanoff, R.-O., Ricardi, U., Short, S. C., Weber, D. C., Belka, C. (2016) ESTRO-ACROP guideline 'target delineation of glioblastomas' Radiotherapy and Oncology, 118, pp. 35-42. (doi: 10.1016/j.radonc.2015.12.003)

  • Uncover new treatments to improve outcomes for patients with adverse prognoses, as well as improved symptom management and survival rate
  • Identification and pre-clinical validation of new chemotherapeutics for use alongside standard of care
  • Use of radiotherapy as a standalone and adjunct therapy
  • Interest in metastasis & invasion of brain cancers
  • Pre-clinical modelling