Dr Matias Perez

  • Newton International Fellow (Host-Parasite Interactions & Pathogenesis)

Biography

Dr Matias Perez is a DVM from Argentina interested in how parasitic helminths modulate the host environment to prolong their survival. During his PhD in Veterinary Medicine at Buenos Aires University, he studied parasitic helminth microRNAs (miRNAs), focusing on tapeworms of human and veterinary importance. He evaluated miRNAs as potential new chemotherapeutic targets of neglected diseases. 

In 2021, he joined the University of Glasgow as a Royal Society Newton International Fellow to examine the effects of helminth miRNAs on host cell gene expression. Here, he was trained and examined parasite-host cell interactions in gastrointestinal (GI) organoids, three-dimensional ‘mini-guts’ derived from GI adult stem cells, that can be maintained in vitro and provide a physiologically relevant platform for studying GI diseases without the need for laboratory animals.

Research interests

My research focuses on how helminth parasite molecules, particularly extracellular small RNAs, can modulate immune response.  

  1. Understand host-parasite interaction.
  2. Elucidate helminth modulation by secreting exRNAs.
  3. Develop new treatments for animal and human parasitic diseases.
  4. Develop innovative treatments for GI parasitic and inflammatory diseases using synthetic miRNAs.
  5. Therapeutic intervention using stable miRNA mimics or inhibitors.

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014
Number of items: 25.

2024

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

Perez, M. (2024) MicroRNAs in infectious and parasitic diseases of dogs. In: Borras, P. (ed.) Practical Manual of Infectious and Parasitic Diseases of the Dog = Manual Práctico de Enfermedades Infecciosas y Parasitarias del Perro. Multimedica. ISBN 9788418636240

Perez, M. (2024) Organoids: In Vitro Platform in Veterinary Research and Precision Medicine. Comparative & Translational Health and Physiology, Ageing & Welfare Away Day, Glasgow, Scotland (Unpublished)

2023

Grecco, A., Macchiaroli, N., Pérez, M. G. , Casulli, A., Cucher, M. A. and Cecilia Rosenzvit, M. (2023) microRNA silencing in a whole worm cestode model provides insight into miR-71 function. International Journal for Parasitology, 53(13), pp. 699-710. (doi: 10.1016/j.ijpara.2023.08.002) (PMID:37699506)

Borrás, P. et al. (2023) First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches. Parasites and Vectors, 16(1), 389. (doi: 10.1186/s13071-023-06022-6) (PMID:37891629) (PMCID:PMC10605978)

Perez, M. (2023) Deciphering the Effect of Haemonchus contortus microRNAs in Host-Parasite Interaction. British Association for Veterinary Parasitology (BAVP) Annual Meeting 2023, Glasgow, Scotland, 14-15 Sep 2023. (Unpublished)

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

Perez, M. , Gillan, V. , Devaney, E. and Britton, C. (2023) Parasitic Nematode miRNAs and EVs - Transfection into Organoid Epithelial Cells [Poster]. Challenges, Opportunities, and New Technologies for Functional Validation of Parasitic Nematode Genes, University of Glasgow, Glasgow UK, March 2023.

Perez, M. (2023) Effects of Parasitic Helminth MicroRNAs on Gastrointestinal Organoids. Mechanisms of Intercellular and Inter-organismal Communication via RNA (exRNA-PATH), Paris, France, 11-12 Sept 2023. (Unpublished)

2022

García, L. C. A., Pérez, M. G. , Ancarola, M. E., Rosenzvit, M. C. and Cucher, M. A. (2022) In vitro system for the growth and asexual multiplication of Taenia crassiceps cysticerci. Parasitology, 149(13), pp. 1775-1780. (doi: 10.1017/S0031182022001354) (PMID:36165285)

Perez, M. G. , Gillan, V. , Maitland, K. , Devaney, E. and Britton, C. (2022) microRNAs in Gastrointestinal Nematode-host Interactions [Poster]. Hydra 2022, Hydra, Greece, 28 Aug-2 Sept 2022.

Pérez, M. G. , Grecco, A. and Rosenzvit, M. C. (2022) MicroRNA interference. In: Xiao, J. (ed.) MicroRNA: From Bench to Bedside. Elsevier (Academic Press), pp. 33-52. ISBN 9780323897747 (doi: 10.1016/B978-0-323-89774-7.00017-0)

Pérez, M. G. , Rego, N., Spiliotis, M., Brehm, K. and Rosenzvit, M. C. (2022) Transcriptional effects of electroporation on Echinococcus multilocularis primary cell culture. Parasitology Research, 121(4), pp. 1155-1168. (doi: 10.1007/s00436-022-07427-5)

2021

Perez, M. G. and Pablo, B. (2021) Zoonotic parasite Spirometra erinaceieuropaei in a domestic cat from Buenos Aires city, Argentina. Revista Argentina de Microbiología, 53(3), pp. 272-273. (doi: 10.1016/j.ram.2020.08.001)

Pérez, M. G. (2021) Taenia solium microRNAs: potential biomarkers and drug targets in neurocysticercosis. In: Morales-Montor, J., Landa, A. and Terrazas, L. I. (eds.) Current State of the Art in Cysticercosis and Neurocysticercosis. IntechOpen. ISBN 9781839693953 (doi: 10.5772/intechopen.97305)

Macchiaroli, N., Preza, M., Pérez, M. G. , Kamenetzky, L., Cucher, M., Koziol, U., Castillo, E., Berriman, M., Brehm, K. and Rosenzvit, M. C. (2021) Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro. PLoS Neglected Tropical Diseases, 15(3), e0009297. (doi: 10.1371/journal.pntd.0009297) (PMID:33750964) (PMCID:PMC8016320)

2020

Arrabal, J. P., Perez, M. , Arce, L. F. and Kamenetzky, L. (2020) First identification and molecular phylogeny of Sparganum proliferum from endangered felid (Panthera onca) and other wild definitive hosts in one of the regions with highest worldwide biodiversity. International Journal for Parasitology: Parasites and Wildlife, 13, pp. 142-149. (doi: 10.1016/j.ijppaw.2020.09.002) (PMID:33083226) (PMCID:PMC7554206)

2019

Pérez, M. G. , Spiliotis, M., Rego, N., Macchiaroli, N., Kamenetzky, L., Holroyd, N., Cucher, M. A., Brehm, K. and Rosenzvit, M. C. (2019) Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro. PLOS Neglected Tropical Diseases, 13(12), e0007932. (doi: 10.1371/journal.pntd.0007932) (PMID:31881019) (PMCID:PMC6957206)

2018

Cardillo, N. M., Ercole, M., Fariña, F., Pasqualetti, M., Loiza, Y., Perez, M. , Bonboni, A. and Ribicich, M. (2018) Corrigendum to “Larval development of Aelurostrongylus abstrusus in experimentally infected Rumina decollata snails” [Vet. Parasitol. 251 (2018) 50–55]. Veterinary Parasitology, 260, p. 5. (doi: 10.1016/j.vetpar.2018.07.010) (PMID:30197014) (PMCID:30197014)

Cardillo, N. M., Ercole, M., Fariña, F., Pasqualetti, M., Loiza, Y., Perez, M. , Bonboni, A. and Ribicich, M. (2018) Larval development of Aelurostrongylus abstrusus in experimentally infected Rumina decollata snails. Veterinary Parasitology, 251, pp. 50-55. (doi: 10.1016/j.vetpar.2018.01.002) (PMID:29426476)

2017

Ancarola, M. E., Marcilla, A., Herz, M., Macchiaroli, N., Pérez, M. , Asurmendi, S., Brehm, K., Poncini, C., Rosenzvit, M. and Cucher, M. (2017) Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo. International Journal for Parasitology, 47(10-11), pp. 675-686. (doi: 10.1016/j.ijpara.2017.05.003)

Pérez, M. G. , Macchiaroli, N., Lichtenstein, G., Conti, G., Asurmendi, S., Milone, D. H., Stegmayer, G., Kamenetzky, L., Cucher, M. and Rosenzvit, M. C. (2017) microRNA analysis of Taenia crassiceps cysticerci under praziquantel treatment and genome-wide identification of Taenia solium miRNAs. International Journal for Parasitology, 47(10-11), pp. 643-653. (doi: 10.1016/j.ijpara.2017.04.002)

Avila, H. G. et al. (2017) Implementation of new tools in molecular epidemiology studies of Echinococcus granulosus sensu lato in South America. Parasitology International, 66(3), pp. 250-257. (doi: 10.1016/j.parint.2017.02.001) (PMID:28193534)

2016

Cardillo, N. et al. (2016) First report of Toxocara cati in the domestic land snail Rumina decollata. Revista Argentina de Microbiología, 48(3), pp. 206-209. (doi: 10.1016/j.ram.2016.04.004) (PMID:27567520)

2014

Cardillo, N., Sommerfelt, I., Fariña, F., Pasqualetti, M., Pérez, M. , Ercole, M., Rosa, A. and Ribicich, M. (2014) A Toxocara cati eggs concentration method from cats’ faeces, for experimental and diagnostic purposes. Experimental Parasitology, 144, pp. 73-75. (doi: 10.1016/j.exppara.2014.06.013) (PMID:24959943)

This list was generated on Thu Sep 19 12:11:43 2024 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 25.

Articles

Grecco, A., Macchiaroli, N., Pérez, M. G. , Casulli, A., Cucher, M. A. and Cecilia Rosenzvit, M. (2023) microRNA silencing in a whole worm cestode model provides insight into miR-71 function. International Journal for Parasitology, 53(13), pp. 699-710. (doi: 10.1016/j.ijpara.2023.08.002) (PMID:37699506)

Borrás, P. et al. (2023) First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches. Parasites and Vectors, 16(1), 389. (doi: 10.1186/s13071-023-06022-6) (PMID:37891629) (PMCID:PMC10605978)

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

García, L. C. A., Pérez, M. G. , Ancarola, M. E., Rosenzvit, M. C. and Cucher, M. A. (2022) In vitro system for the growth and asexual multiplication of Taenia crassiceps cysticerci. Parasitology, 149(13), pp. 1775-1780. (doi: 10.1017/S0031182022001354) (PMID:36165285)

Pérez, M. G. , Rego, N., Spiliotis, M., Brehm, K. and Rosenzvit, M. C. (2022) Transcriptional effects of electroporation on Echinococcus multilocularis primary cell culture. Parasitology Research, 121(4), pp. 1155-1168. (doi: 10.1007/s00436-022-07427-5)

Perez, M. G. and Pablo, B. (2021) Zoonotic parasite Spirometra erinaceieuropaei in a domestic cat from Buenos Aires city, Argentina. Revista Argentina de Microbiología, 53(3), pp. 272-273. (doi: 10.1016/j.ram.2020.08.001)

Macchiaroli, N., Preza, M., Pérez, M. G. , Kamenetzky, L., Cucher, M., Koziol, U., Castillo, E., Berriman, M., Brehm, K. and Rosenzvit, M. C. (2021) Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro. PLoS Neglected Tropical Diseases, 15(3), e0009297. (doi: 10.1371/journal.pntd.0009297) (PMID:33750964) (PMCID:PMC8016320)

Arrabal, J. P., Perez, M. , Arce, L. F. and Kamenetzky, L. (2020) First identification and molecular phylogeny of Sparganum proliferum from endangered felid (Panthera onca) and other wild definitive hosts in one of the regions with highest worldwide biodiversity. International Journal for Parasitology: Parasites and Wildlife, 13, pp. 142-149. (doi: 10.1016/j.ijppaw.2020.09.002) (PMID:33083226) (PMCID:PMC7554206)

Pérez, M. G. , Spiliotis, M., Rego, N., Macchiaroli, N., Kamenetzky, L., Holroyd, N., Cucher, M. A., Brehm, K. and Rosenzvit, M. C. (2019) Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro. PLOS Neglected Tropical Diseases, 13(12), e0007932. (doi: 10.1371/journal.pntd.0007932) (PMID:31881019) (PMCID:PMC6957206)

Cardillo, N. M., Ercole, M., Fariña, F., Pasqualetti, M., Loiza, Y., Perez, M. , Bonboni, A. and Ribicich, M. (2018) Corrigendum to “Larval development of Aelurostrongylus abstrusus in experimentally infected Rumina decollata snails” [Vet. Parasitol. 251 (2018) 50–55]. Veterinary Parasitology, 260, p. 5. (doi: 10.1016/j.vetpar.2018.07.010) (PMID:30197014) (PMCID:30197014)

Cardillo, N. M., Ercole, M., Fariña, F., Pasqualetti, M., Loiza, Y., Perez, M. , Bonboni, A. and Ribicich, M. (2018) Larval development of Aelurostrongylus abstrusus in experimentally infected Rumina decollata snails. Veterinary Parasitology, 251, pp. 50-55. (doi: 10.1016/j.vetpar.2018.01.002) (PMID:29426476)

Ancarola, M. E., Marcilla, A., Herz, M., Macchiaroli, N., Pérez, M. , Asurmendi, S., Brehm, K., Poncini, C., Rosenzvit, M. and Cucher, M. (2017) Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo. International Journal for Parasitology, 47(10-11), pp. 675-686. (doi: 10.1016/j.ijpara.2017.05.003)

Pérez, M. G. , Macchiaroli, N., Lichtenstein, G., Conti, G., Asurmendi, S., Milone, D. H., Stegmayer, G., Kamenetzky, L., Cucher, M. and Rosenzvit, M. C. (2017) microRNA analysis of Taenia crassiceps cysticerci under praziquantel treatment and genome-wide identification of Taenia solium miRNAs. International Journal for Parasitology, 47(10-11), pp. 643-653. (doi: 10.1016/j.ijpara.2017.04.002)

Avila, H. G. et al. (2017) Implementation of new tools in molecular epidemiology studies of Echinococcus granulosus sensu lato in South America. Parasitology International, 66(3), pp. 250-257. (doi: 10.1016/j.parint.2017.02.001) (PMID:28193534)

Cardillo, N. et al. (2016) First report of Toxocara cati in the domestic land snail Rumina decollata. Revista Argentina de Microbiología, 48(3), pp. 206-209. (doi: 10.1016/j.ram.2016.04.004) (PMID:27567520)

Cardillo, N., Sommerfelt, I., Fariña, F., Pasqualetti, M., Pérez, M. , Ercole, M., Rosa, A. and Ribicich, M. (2014) A Toxocara cati eggs concentration method from cats’ faeces, for experimental and diagnostic purposes. Experimental Parasitology, 144, pp. 73-75. (doi: 10.1016/j.exppara.2014.06.013) (PMID:24959943)

Book Sections

Perez, M. (2024) MicroRNAs in infectious and parasitic diseases of dogs. In: Borras, P. (ed.) Practical Manual of Infectious and Parasitic Diseases of the Dog = Manual Práctico de Enfermedades Infecciosas y Parasitarias del Perro. Multimedica. ISBN 9788418636240

Pérez, M. G. , Grecco, A. and Rosenzvit, M. C. (2022) MicroRNA interference. In: Xiao, J. (ed.) MicroRNA: From Bench to Bedside. Elsevier (Academic Press), pp. 33-52. ISBN 9780323897747 (doi: 10.1016/B978-0-323-89774-7.00017-0)

Pérez, M. G. (2021) Taenia solium microRNAs: potential biomarkers and drug targets in neurocysticercosis. In: Morales-Montor, J., Landa, A. and Terrazas, L. I. (eds.) Current State of the Art in Cysticercosis and Neurocysticercosis. IntechOpen. ISBN 9781839693953 (doi: 10.5772/intechopen.97305)

Conference or Workshop Item

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

Perez, M. (2024) Organoids: In Vitro Platform in Veterinary Research and Precision Medicine. Comparative & Translational Health and Physiology, Ageing & Welfare Away Day, Glasgow, Scotland (Unpublished)

Perez, M. (2023) Deciphering the Effect of Haemonchus contortus microRNAs in Host-Parasite Interaction. British Association for Veterinary Parasitology (BAVP) Annual Meeting 2023, Glasgow, Scotland, 14-15 Sep 2023. (Unpublished)

Perez, M. , Gillan, V. , Devaney, E. and Britton, C. (2023) Parasitic Nematode miRNAs and EVs - Transfection into Organoid Epithelial Cells [Poster]. Challenges, Opportunities, and New Technologies for Functional Validation of Parasitic Nematode Genes, University of Glasgow, Glasgow UK, March 2023.

Perez, M. (2023) Effects of Parasitic Helminth MicroRNAs on Gastrointestinal Organoids. Mechanisms of Intercellular and Inter-organismal Communication via RNA (exRNA-PATH), Paris, France, 11-12 Sept 2023. (Unpublished)

Perez, M. G. , Gillan, V. , Maitland, K. , Devaney, E. and Britton, C. (2022) microRNAs in Gastrointestinal Nematode-host Interactions [Poster]. Hydra 2022, Hydra, Greece, 28 Aug-2 Sept 2022.

This list was generated on Thu Sep 19 12:11:43 2024 BST.

Supervision

Co-supervisor Masters in Veterinary Medicine (MVM) Postgraduate students, Univ Glasgow, (2022-present):

1) microRNAs as biomarkers in anal sac adenocarcinoma

2) microRNAs as biomarkers in dog epilepsy

  1. Co-supervisor Honours student in Veterinary Biosciences, Uni of Glasgow, (2024): Using organoids to study host-parasite interactions, focussing on parasite microRNAs.
  2. Co-supervisor Final year student in Biotechnology, Uni of Business - School of Engineering and Exact Sciences (UADE), Buenos Aires (2023): Optimization of asexual reproduction in vitro of the cestode Taenia crassiceps. 

Matias in the Lab