2025

Campillo Poveda, M. et al. (2025) Metabolomic and functional analyses of small molecules secreted by intestinal nematodes in the activation of epithelial tuft cells. Metabolomics, (Accepted for Publication)

Brinzer, R. A. , McIntyre, J. R. , Britton, C. and Laing, R. (2025) The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro. International Journal for Parasitology, 55(2), pp. 117-128. (doi: 10.1016/j.ijpara.2024.11.004) (PMID:39617094)

2024

Ndjim, M. et al. (2024) Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity. Immunity, 57(6), 1260-1273.e7. (doi: 10.1016/j.immuni.2024.04.018) (PMID:38744292)

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

2023

Borrás, P. et al. (2023) First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches. Parasites and Vectors, 16(1), 389. (doi: 10.1186/s13071-023-06022-6) (PMID:37891629) (PMCID:PMC10605978)

Campillo Poveda, M. , Britton, C. , Devaney, E. , McNeilly, T. N., Gerbe, F., Jay, P. and Maizels, R. M. (2023) Tuft cells: detectors, amplifiers, effectors and targets in parasite infection. Cells, 12(20), 2477. (doi: 10.3390/cells12202477) (PMID:37887321) (PMCID:PMC10605326)

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

Perez, M. , Gillan, V. , Devaney, E. and Britton, C. (2023) Parasitic Nematode miRNAs and EVs - Transfection into Organoid Epithelial Cells [Poster]. Challenges, Opportunities, and New Technologies for Functional Validation of Parasitic Nematode Genes, University of Glasgow, Glasgow UK, March 2023.

2022

Doyle, S. R. et al. (2022) Genomic landscape of drug response reveals mediators of anthelmintic resistance. Cell Reports, 41(3), 111522. (doi: 10.1016/j.celrep.2022.111522) (PMID:36261007) (PMCID:PMC9597552)

Perez, M. G. , Gillan, V. , Maitland, K. , Devaney, E. and Britton, C. (2022) microRNAs in Gastrointestinal Nematode-host Interactions [Poster]. Hydra 2022, Hydra, Greece, 28 Aug-2 Sept 2022.

Lins, J. G. G., Almeida, F. A., Albuquerque, A. C. A., Britton, C. and Amarante, A. F.T. (2022) Early-onset immune response to Haemonchus contortus infection in resistant Santa Ines suckling lambs compared with susceptible Ile de France. Veterinary Parasitology, 307-8, 109734. (doi: 10.1016/j.vetpar.2022.109734) (PMID:35660130)

Laing, R. et al. (2022) Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode. PLoS Pathogens, 18(6), e1010545. (doi: 10.1371/journal.ppat.1010545) (PMID:35696434) (PMCID:PMC9232149)

2021

Hildersley, K. A., Mcneilly, T. N., Gillan, V. , Otto, T. D. , Löser, S., Gerbe, F., Jay, P., Maizels, R. M. , Devaney, E. and Britton, C. (2021) Tuft cells increase following ovine intestinal parasite infections and define evolutionarily conserved and divergent responses. Frontiers in Immunology, 12, 781108. (doi: 10.3389/fimmu.2021.781108) (PMID:34880874) (PMCID:PMC8646091)

2020

Doyle, S. R. et al. (2020) Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm. Communications Biology, 3, 656. (doi: 10.1038/s42003-020-01377-3) (PMID:33168940) (PMCID:PMC7652881)

Britton, C. , Laing, R. and Devaney, E. (2020) Small RNAs in parasitic nematodes - forms and functions. Parasitology, 147(8), pp. 855-864. (doi: 10.1017/S0031182019001689) (PMID:31843030) (PMCID:PMC7284814)

Britton, C. , Emery, D. L., Mcneilly, T., Nisbet, A. and Stear, M. J. (2020) The potential for vaccines against scour worms of small ruminants. International Journal for Parasitology, 50(8), pp. 533-553. (doi: 10.1016/j.ijpara.2020.04.003) (PMID:32569640)

Hanks, E., Todd, H., Palarea-Albaladejo, J., Mcneilly, T. N., Britton, C. and Ballingall, K. T. (2020) A novel technique for retrospective genetic analysis of the response to vaccination or infection using cell-free DNA from archived sheep serum and plasma. Veterinary Research, 51(1), 9. (doi: 10.1186/s13567-020-0737-9) (PMID:32024546) (PMCID:PMC7003321)

2019

Albuquerque, A. C. A., Bassetto, C. C., Almeida, F. A., Hildersley, K. A., McNeilly, T. N., Britton, C. and Amarante, A. F.T. (2019) Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens. Veterinary Research, 50, 104. (doi: 10.1186/s13567-019-0722-3) (PMID:31783921) (PMCID:PMC6884896)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)

2018

Sallé, G. et al. (2018) Transcriptomic profiling of nematode parasites surviving vaccine exposure. International Journal for Parasitology, 48(5), pp. 395-402. (doi: 10.1016/j.ijpara.2018.01.004) (PMID:29534987) (PMCID:PMC5909036)

Palevich, N., Britton, C. , Kamenetzky, L., Mitreva, M., de Moraes Mourão, M., Bennuru, S., Quack, T., Scholte, L. L. S., Tyagi, R. and Slatko, B. E. (2018) Tackling hypotheticals in helminth genomes. Trends in Parasitology, 34(3), pp. 179-183. (doi: 10.1016/j.pt.2017.11.007) (PMID:29249363)

Doyle, S. R. et al. (2018) A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Genome Biology and Evolution, 10(2), pp. 396-409. (doi: 10.1093/gbe/evx269) (PMID:29267942) (PMCID:PMC5793844)

2017

Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)

Terron-Canedo, N., Weir, W. , Nicolson, L., Britton, C. and Nasir, L. (2017) Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells. Veterinary and Comparative Oncology, 15(3), pp. 764-774. (doi: 10.1111/vco.12216) (PMID:27039895)

Britton, C. (2017) microRNAs - key players in host-parasite interactions. Parasite Immunology, 39(2), e12418. (doi: 10.1111/pim.12418) (PMID:28171701)

Gu, H. Y., Marks, N. D., Winter, A. D., Weir, W. , Tzelos, T., McNeilly, T. N., Britton, C. and Devaney, E. (2017) Conservation of a microRNA cluster in parasitic nematodes and profiling of miRNAs in excretory-secretory products and microvesicles of Haemonchus contortus. PLoS Neglected Tropical Diseases, 11(11), e0006056. (doi: 10.1371/journal.pntd.0006056) (PMID:29145392) (PMCID:PMC5709059)

2016

Britton, C. , Roberts, B. and Marks, N.D. (2016) Functional genomics tools for Haemonchus contortus and lessons from other helminths. Advances in Parasitology, 93, pp. 599-623. (doi: 10.1016/bs.apar.2016.02.017) (PMID:27238014)

2015

Britton, C. , Winter, A. D., Marks, N. D., Gu, H., McNeilly, T. N., Gillan, V. and Devaney, E. (2015) Application of small RNA technology for improved control of parasitic helminths. Veterinary Parasitology, 212(1-2), pp. 47-53. (doi: 10.1016/j.vetpar.2015.06.003) (PMID:26095949) (PMCID:PMC4535316)

Britton, C. (2015) Ascaris: The Neglected Parasite, by Celia Holland. Parasitology, 142(4), p. 633. (doi: 10.1017/S0031182014001541)[Book Review]

Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi: 10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)

2014

Britton, C. , Winter, A. D., Gillan, V. and Devaney, E. (2014) microRNAs of parasitic helminths – identification, characterization and potential as drug targets. International Journal for Parasitology: Drugs and Drug Resistance, 4(2), pp. 85-94. (doi: 10.1016/j.ijpddr.2014.03.001)

2013

Roberts, B., Antonopoulos, A., Haslam, S.M., Dicker, A.J., Mcneilly, T.N., Johnston, S.L., Dell, A., Knox, D.P. and Britton, C. (2013) Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans. Veterinary Research, 44, 111. (doi: 10.1186/1297-9716-44-111) (PMID:24289031) (PMCID:PMC4176091)

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi: 10.1186/gb-2013-14-8-r88) (PMID:23985316) (PMCID:PMC4054779)

Saunders, G. I., Wasmuth, J. D., Beech, R., Laing, R. , Hunt, M., Naghra, H., Cotton, J. A. , Berriman, M., Britton, C. and Gilleard, J. S. (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011) (PMID:23416426)

Britton, C. (2013) Proteases of nematodes: from free-living to parasite. In: Kennedy, M.W. and Harnett, W. (eds.) Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology. Cabi Publishing, pp. 354-374. ISBN 9781845937591 (doi: 10.1079/9781845937591.0351)

Caffrey, C.R., Britton, C. and McKerrow, J.H. (2013) Helminth cysteine proteases. In: Rawlings, N.D. and Salvesen, G. (eds.) Handbook of Proteolytic Enzymes. Elsevier Science, pp. 1949-1957. ISBN 9780123822192 (doi: 10.1016/B978-0-12-382219-2.00444-0)

2012

Baker, R.H., Britton, C. , Roberts, B., Loer, C.M., Matthews, J.B. and Nisbet, A.J. (2012) Melanisation of teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-Cyclohydrolase in nematode survival. International Journal for Parasitology, 42(10), pp. 887-891. (doi: 10.1016/j.ijpara.2012.06.005)

Baker, R.H., Britton, C. , Roberts, B., Loer, C.M., Matthews, J.B. and Nisbet, A.J. (2012) Melanisation of Teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-cyclohydrolase in nematode survival. International Journal for Parasitology, 42(10), pp. 887-891. (doi: 10.1016/j.ijpara.2012.06.005)

Selkirk, M.E., Huang, S.C., Knox, D.P. and Britton, C. (2012) The development of RNA interference (RNAi) in gastrointestinal nematodes. Parasitology, 139(5), pp. 605-612. (doi: 10.1017/S0031182011002332)

Britton, C. , Samarasinghe, B. and Knox, D.P. (2012) Ups and downs of RNA interference in parasitic nematodes. Experimental Parasitology, 132(1), pp. 56-61. (doi: 10.1016/j.exppara.2011.08.002)

Britton, C. (2012) RNA interference: A potential discovery tool for therapeutic targets of parasitic nematodes. In: Parasitic helminths: Targets, screens, drugs and vaccines. Wiley-Blackwell, pp. 89-103.

Winter, A.D., Weir, W. , Hunt, M., Berriman, M., Gilleard, J.S., Devaney, E. and Britton, C. (2012) Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics, 13, p. 4. (doi: 10.1186/1471-2164-13-4)

2011

Samarasinghe, S.B., Knox, D.P. and Britton, C. (2011) Factors affecting susceptibility to RNA interference in Haemonchus contortus and in vivo silencing of an H11 aminopeptidase gene. International Journal for Parasitology, 41(1), pp. 51-59. (doi: 10.1016/j.ijpara.2010.07.005)

2010

Devaney, E.A. , Winter, A.D. and Britton, C. (2010) microRNAs: a role in drug resistance in parasitic nematodes? Trends in Parasitology, 26(9), pp. 428-433. (doi: 10.1016/j.pt.2010.05.003) (PMID:20541972) (PMCID:PMC2930248)

2009

Nic An Ultaigh, S., Carolan, J. C., Britton, C. , Murray, L. and Ryan, M. F. (2009) A cathepsin L-like protease from Strongylus vulgaris: an orthologue of Caenorhabditis elegans CPL-1. Experimental Parasitology, 121(4), pp. 293-299. (doi: 10.1016/j.exppara.2008.11.002) (PMID:19059238)

2008

Britton, C. (2008) Genetically modified parasites and the immune response. Parasite Immunology, 30(4), pp. 191-193. (doi: 10.1111/j.1365-3024.2008.01018.x)

2007

Geldhof, P., Visser, A., Clark, D., Saunders, G., Britton, C., Gilleard, J., Berriman, M. and Knox, D. (2007) RNA interference in parasitic helminths: current situation, potential pitfalls and future prospects. Parasitology, 134, pp. 609-619. (doi: 10.1017/S0031182006002071) (PMID:17201997)

Knox, D. P., Geldhof, P., Visser, A. and Britton, C. (2007) RNA interference in parasitic nematodes of animals: a reality check? Trends in Parasitology, 23(3), pp. 105-107. (doi: 10.1016/j.pt.2007.01.007) (PMID:17276139)

Murray, L., Geldhof, P., Clark, D., Knox, D. P. and Britton, C. (2007) Expression and purification of an active cysteine protease of Haemonchus contortus using Caenorhabditis elegans. Trends in Parasitology, 37(10), pp. 1117-1125. (doi: 10.1016/j.ijpara.2007.02.012) (PMID:17451718)

2006

Britton, C. and Murray, L. (2006) Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes. International Journal for Parasitology, 36(6), pp. 651-659. (doi: 10.1016/j.ijpara.2006.02.010) (PMID:16616144)

Geldhof, P., Murray, L., Couthier, A., Gilleard, J. S., McLauchlan, G., Knox, D. P. and Britton, C. (2006) Testing the efficacy of RNA interference in Haemonchus contortus. International Journal for Parasitology, 36(7), pp. 801-810. (doi: 10.1016/j.ijpara.2005.12.004) (PMID:16469321)

2004

Britton, C. and Murray, L. (2004) Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans. Journal of Cell Science, 117, pp. 5133-5143. (doi: 10.1242/jcs.01387)

2002

Britton, C. and Murray, L. (2002) A cathepsin L protease essential for Caenorhabditis elegans embryogenesis is functionally conserved in parasitic nematodes. Molecular and Biochemical Parasitology, 122, pp. 21-33.

Gomez-Escobar, N., Gregory, W., Britton, C. , Murray, L., Corton, C., Hall, N., Daub, J., Blaxter, M. and Maizels, R. (2002) Abundant larval transcript-1 and -2 genes from Brugia malayi: diversity of genomic environments but conservation of 5 ' promoter sequences functional in Caenorhabditis elegans. Molecular and Biochemical Parasitology, 125, pp. 59-71.

Hashmi, S., Britton, C. , Liu, J., Guiliano, D., Oksov, Y. and Lustigman, S. (2002) Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. Journal of Biological Chemistry, 277, pp. 3477-3486. (doi: 10.1074/jbc.M106117200)

Thompson, F., Britton, C. , Wheatley, I., Maitland, K., Walker, G., Anant, S., Davidson, N. and Devaney, E. (2002) Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Biochemical Journal, 365, pp. 99-107.

2001

Thompson, F., Cockroft, A., Wheatley, I., Britton, C. and Devaney, E. (2001) Heat shock and developmental expression of hsp83 in the filarial nematode Brugia pahangi. European Journal of Biochemistry, 268, pp. 5808-5815.

1999

Britton, C. , Redmond, D. L., Knox, D. P., McKerrow, J. H. and Barry, J. D. (1999) Identification of promoter elements of parasitic nematodes in transgenic Caenorhabditis elegans. Molecular and Biochemical Parasitology, 103(2), pp. 171-181. (doi: 10.1016/S0166-6851(99)00121-8) (PMID:10551361)

1998

Britton, C. , McKerrow, J. H. and Johnstone, I. L. (1998) Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. Journal of Molecular Biology, 283(1), pp. 15-27. (doi: 10.1006/jmbi.1998.2093) (PMID:9761670)

1997

McCririe, L., Bairden, K., Britton, C. , Buitkamp, J., McKeand, J.B. and Stear, M.J. (1997) Heterogeneity in the recognition of Ostertagia circumcincta antigens by serum antibody from mature, infected sheep. Parasite Immunology, 19(5), pp. 235-242. (doi: 10.1046/j.1365-3024.1997.d01-202.x) (PMID:9194101)

1995

Kennedy, M. W. , Britton, C. , Price, N. C., Kelly, S. M. and Cooper, A. (1995) The DvA-1 polyprotein of the parasitic nematode Dictyocaulus viviparus. A small helix-rich lipid-binding protein. Journal of Biological Chemistry, 270(33), pp. 19277-19281. (doi: 10.1074/jbc.270.33.19277) (PMID:7642601)

Britton, C. , Moore, J., Gilleard, J. S. and Kennedy, M. W. (1995) Extensive diversity in repeat unit sequences of the cDNA encoding the polyprotein antigen/allergen from the bovine lungworm Dictyocaulus viviparus. Molecular and Biochemical Parasitology, 72(1-2), pp. 77-88. (doi: 10.1016/0166-6851(95)00088-I) (PMID:8538702)

1994

Britton, C. , Knox, D.P. and Kennedy, M.W. (1994) Superoxide dismutase (SOD) activity of Dictyocaulus viviparus and its inhibition by antibody from infected and vaccinated bovine hosts. Parasitology, 109(2), pp. 257-263. (doi: 10.1017/s0031182000076381) (PMID:8084670)

1993

Britton, C. , Canto, G. J., Urquhart, G. M. and Kennedy, M. W. (1993) Stage-specific surface antigens of the cattle lungworm Dictyocaulus viviparus. Parasite Immunology, 15(11), pp. 625-634. (doi: 10.1111/j.1365-3024.1993.tb00576.x) (PMID:7877839)

Britton, C. , Canto, G., Urquhart, G. M. and Kennedy, M. W. (1993) Characterization of excretory-secretory products of adult Dictyocaulus viviparus and the antibody response to them in infection and vaccination. Parasite Immunology, 15(3), pp. 163-174. (doi: 10.1111/j.1365-3024.1993.tb00596.x) (PMID:8316410)

Britton, C. , Knox, D. P. and Kennedy, M. W. (1993) Excretory-Secretory Superoxide Dismutase (SOD) of the Bovine Lungworm Dictyocaulus Viviparus. Molecular Helminthology: An Integrated Approach, Tamarron, Colorado, USA, 10-17 Feb 1993. (doi: 10.1002/jcb.240530704)

1992

Britton, C. , Knox, D.P., Canto, G.J., Urquhart, G.M. and Kennedy, M.W. (1992) The secreted and somatic proteinases of the bovine lungworm Dictyocaulus viviparus and their inhibition by antibody from infected and vaccinated animals. Parasitology, 105(2), pp. 325-333. (doi: 10.1017/s0031182000074254) (PMID:1454428)

Britton, C. , Canto, G. J., Urquhart, G. M. and Kennedy, M. W. (1992) The antibody repertoire in infection and vaccination with Dictyocaulus viviparus: heterogeneity in infected cattle and genetic control in guinea pigs. Veterinary Immunology and Immunopathology, 31(3-4), pp. 313-322. (doi: 10.1016/0165-2427(92)90018-L) (PMID:1534189)

Articles

Campillo Poveda, M. et al. (2025) Metabolomic and functional analyses of small molecules secreted by intestinal nematodes in the activation of epithelial tuft cells. Metabolomics, (Accepted for Publication)

Brinzer, R. A. , McIntyre, J. R. , Britton, C. and Laing, R. (2025) The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro. International Journal for Parasitology, 55(2), pp. 117-128. (doi: 10.1016/j.ijpara.2024.11.004) (PMID:39617094)

Ndjim, M. et al. (2024) Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity. Immunity, 57(6), 1260-1273.e7. (doi: 10.1016/j.immuni.2024.04.018) (PMID:38744292)

Borrás, P. et al. (2023) First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches. Parasites and Vectors, 16(1), 389. (doi: 10.1186/s13071-023-06022-6) (PMID:37891629) (PMCID:PMC10605978)

Campillo Poveda, M. , Britton, C. , Devaney, E. , McNeilly, T. N., Gerbe, F., Jay, P. and Maizels, R. M. (2023) Tuft cells: detectors, amplifiers, effectors and targets in parasite infection. Cells, 12(20), 2477. (doi: 10.3390/cells12202477) (PMID:37887321) (PMCID:PMC10605326)

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

Doyle, S. R. et al. (2022) Genomic landscape of drug response reveals mediators of anthelmintic resistance. Cell Reports, 41(3), 111522. (doi: 10.1016/j.celrep.2022.111522) (PMID:36261007) (PMCID:PMC9597552)

Lins, J. G. G., Almeida, F. A., Albuquerque, A. C. A., Britton, C. and Amarante, A. F.T. (2022) Early-onset immune response to Haemonchus contortus infection in resistant Santa Ines suckling lambs compared with susceptible Ile de France. Veterinary Parasitology, 307-8, 109734. (doi: 10.1016/j.vetpar.2022.109734) (PMID:35660130)

Laing, R. et al. (2022) Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode. PLoS Pathogens, 18(6), e1010545. (doi: 10.1371/journal.ppat.1010545) (PMID:35696434) (PMCID:PMC9232149)

Hildersley, K. A., Mcneilly, T. N., Gillan, V. , Otto, T. D. , Löser, S., Gerbe, F., Jay, P., Maizels, R. M. , Devaney, E. and Britton, C. (2021) Tuft cells increase following ovine intestinal parasite infections and define evolutionarily conserved and divergent responses. Frontiers in Immunology, 12, 781108. (doi: 10.3389/fimmu.2021.781108) (PMID:34880874) (PMCID:PMC8646091)

Doyle, S. R. et al. (2020) Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm. Communications Biology, 3, 656. (doi: 10.1038/s42003-020-01377-3) (PMID:33168940) (PMCID:PMC7652881)

Britton, C. , Laing, R. and Devaney, E. (2020) Small RNAs in parasitic nematodes - forms and functions. Parasitology, 147(8), pp. 855-864. (doi: 10.1017/S0031182019001689) (PMID:31843030) (PMCID:PMC7284814)

Britton, C. , Emery, D. L., Mcneilly, T., Nisbet, A. and Stear, M. J. (2020) The potential for vaccines against scour worms of small ruminants. International Journal for Parasitology, 50(8), pp. 533-553. (doi: 10.1016/j.ijpara.2020.04.003) (PMID:32569640)

Hanks, E., Todd, H., Palarea-Albaladejo, J., Mcneilly, T. N., Britton, C. and Ballingall, K. T. (2020) A novel technique for retrospective genetic analysis of the response to vaccination or infection using cell-free DNA from archived sheep serum and plasma. Veterinary Research, 51(1), 9. (doi: 10.1186/s13567-020-0737-9) (PMID:32024546) (PMCID:PMC7003321)

Albuquerque, A. C. A., Bassetto, C. C., Almeida, F. A., Hildersley, K. A., McNeilly, T. N., Britton, C. and Amarante, A. F.T. (2019) Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens. Veterinary Research, 50, 104. (doi: 10.1186/s13567-019-0722-3) (PMID:31783921) (PMCID:PMC6884896)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)

Sallé, G. et al. (2018) Transcriptomic profiling of nematode parasites surviving vaccine exposure. International Journal for Parasitology, 48(5), pp. 395-402. (doi: 10.1016/j.ijpara.2018.01.004) (PMID:29534987) (PMCID:PMC5909036)

Palevich, N., Britton, C. , Kamenetzky, L., Mitreva, M., de Moraes Mourão, M., Bennuru, S., Quack, T., Scholte, L. L. S., Tyagi, R. and Slatko, B. E. (2018) Tackling hypotheticals in helminth genomes. Trends in Parasitology, 34(3), pp. 179-183. (doi: 10.1016/j.pt.2017.11.007) (PMID:29249363)

Doyle, S. R. et al. (2018) A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Genome Biology and Evolution, 10(2), pp. 396-409. (doi: 10.1093/gbe/evx269) (PMID:29267942) (PMCID:PMC5793844)

Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)

Terron-Canedo, N., Weir, W. , Nicolson, L., Britton, C. and Nasir, L. (2017) Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells. Veterinary and Comparative Oncology, 15(3), pp. 764-774. (doi: 10.1111/vco.12216) (PMID:27039895)

Britton, C. (2017) microRNAs - key players in host-parasite interactions. Parasite Immunology, 39(2), e12418. (doi: 10.1111/pim.12418) (PMID:28171701)

Gu, H. Y., Marks, N. D., Winter, A. D., Weir, W. , Tzelos, T., McNeilly, T. N., Britton, C. and Devaney, E. (2017) Conservation of a microRNA cluster in parasitic nematodes and profiling of miRNAs in excretory-secretory products and microvesicles of Haemonchus contortus. PLoS Neglected Tropical Diseases, 11(11), e0006056. (doi: 10.1371/journal.pntd.0006056) (PMID:29145392) (PMCID:PMC5709059)

Britton, C. , Roberts, B. and Marks, N.D. (2016) Functional genomics tools for Haemonchus contortus and lessons from other helminths. Advances in Parasitology, 93, pp. 599-623. (doi: 10.1016/bs.apar.2016.02.017) (PMID:27238014)

Britton, C. , Winter, A. D., Marks, N. D., Gu, H., McNeilly, T. N., Gillan, V. and Devaney, E. (2015) Application of small RNA technology for improved control of parasitic helminths. Veterinary Parasitology, 212(1-2), pp. 47-53. (doi: 10.1016/j.vetpar.2015.06.003) (PMID:26095949) (PMCID:PMC4535316)

Winter, A. D. et al. (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16, 331. (doi: 10.1186/s12864-015-1536-y) (PMID:25896062) (PMCID:PMC4428239)

Britton, C. , Winter, A. D., Gillan, V. and Devaney, E. (2014) microRNAs of parasitic helminths – identification, characterization and potential as drug targets. International Journal for Parasitology: Drugs and Drug Resistance, 4(2), pp. 85-94. (doi: 10.1016/j.ijpddr.2014.03.001)

Roberts, B., Antonopoulos, A., Haslam, S.M., Dicker, A.J., Mcneilly, T.N., Johnston, S.L., Dell, A., Knox, D.P. and Britton, C. (2013) Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans. Veterinary Research, 44, 111. (doi: 10.1186/1297-9716-44-111) (PMID:24289031) (PMCID:PMC4176091)

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi: 10.1186/gb-2013-14-8-r88) (PMID:23985316) (PMCID:PMC4054779)

Saunders, G. I., Wasmuth, J. D., Beech, R., Laing, R. , Hunt, M., Naghra, H., Cotton, J. A. , Berriman, M., Britton, C. and Gilleard, J. S. (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011) (PMID:23416426)

Baker, R.H., Britton, C. , Roberts, B., Loer, C.M., Matthews, J.B. and Nisbet, A.J. (2012) Melanisation of teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-Cyclohydrolase in nematode survival. International Journal for Parasitology, 42(10), pp. 887-891. (doi: 10.1016/j.ijpara.2012.06.005)

Baker, R.H., Britton, C. , Roberts, B., Loer, C.M., Matthews, J.B. and Nisbet, A.J. (2012) Melanisation of Teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-cyclohydrolase in nematode survival. International Journal for Parasitology, 42(10), pp. 887-891. (doi: 10.1016/j.ijpara.2012.06.005)

Selkirk, M.E., Huang, S.C., Knox, D.P. and Britton, C. (2012) The development of RNA interference (RNAi) in gastrointestinal nematodes. Parasitology, 139(5), pp. 605-612. (doi: 10.1017/S0031182011002332)

Britton, C. , Samarasinghe, B. and Knox, D.P. (2012) Ups and downs of RNA interference in parasitic nematodes. Experimental Parasitology, 132(1), pp. 56-61. (doi: 10.1016/j.exppara.2011.08.002)

Winter, A.D., Weir, W. , Hunt, M., Berriman, M., Gilleard, J.S., Devaney, E. and Britton, C. (2012) Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics, 13, p. 4. (doi: 10.1186/1471-2164-13-4)

Samarasinghe, S.B., Knox, D.P. and Britton, C. (2011) Factors affecting susceptibility to RNA interference in Haemonchus contortus and in vivo silencing of an H11 aminopeptidase gene. International Journal for Parasitology, 41(1), pp. 51-59. (doi: 10.1016/j.ijpara.2010.07.005)

Devaney, E.A. , Winter, A.D. and Britton, C. (2010) microRNAs: a role in drug resistance in parasitic nematodes? Trends in Parasitology, 26(9), pp. 428-433. (doi: 10.1016/j.pt.2010.05.003) (PMID:20541972) (PMCID:PMC2930248)

Nic An Ultaigh, S., Carolan, J. C., Britton, C. , Murray, L. and Ryan, M. F. (2009) A cathepsin L-like protease from Strongylus vulgaris: an orthologue of Caenorhabditis elegans CPL-1. Experimental Parasitology, 121(4), pp. 293-299. (doi: 10.1016/j.exppara.2008.11.002) (PMID:19059238)

Britton, C. (2008) Genetically modified parasites and the immune response. Parasite Immunology, 30(4), pp. 191-193. (doi: 10.1111/j.1365-3024.2008.01018.x)

Geldhof, P., Visser, A., Clark, D., Saunders, G., Britton, C., Gilleard, J., Berriman, M. and Knox, D. (2007) RNA interference in parasitic helminths: current situation, potential pitfalls and future prospects. Parasitology, 134, pp. 609-619. (doi: 10.1017/S0031182006002071) (PMID:17201997)

Knox, D. P., Geldhof, P., Visser, A. and Britton, C. (2007) RNA interference in parasitic nematodes of animals: a reality check? Trends in Parasitology, 23(3), pp. 105-107. (doi: 10.1016/j.pt.2007.01.007) (PMID:17276139)

Murray, L., Geldhof, P., Clark, D., Knox, D. P. and Britton, C. (2007) Expression and purification of an active cysteine protease of Haemonchus contortus using Caenorhabditis elegans. Trends in Parasitology, 37(10), pp. 1117-1125. (doi: 10.1016/j.ijpara.2007.02.012) (PMID:17451718)

Britton, C. and Murray, L. (2006) Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes. International Journal for Parasitology, 36(6), pp. 651-659. (doi: 10.1016/j.ijpara.2006.02.010) (PMID:16616144)

Geldhof, P., Murray, L., Couthier, A., Gilleard, J. S., McLauchlan, G., Knox, D. P. and Britton, C. (2006) Testing the efficacy of RNA interference in Haemonchus contortus. International Journal for Parasitology, 36(7), pp. 801-810. (doi: 10.1016/j.ijpara.2005.12.004) (PMID:16469321)

Britton, C. and Murray, L. (2004) Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans. Journal of Cell Science, 117, pp. 5133-5143. (doi: 10.1242/jcs.01387)

Britton, C. and Murray, L. (2002) A cathepsin L protease essential for Caenorhabditis elegans embryogenesis is functionally conserved in parasitic nematodes. Molecular and Biochemical Parasitology, 122, pp. 21-33.

Gomez-Escobar, N., Gregory, W., Britton, C. , Murray, L., Corton, C., Hall, N., Daub, J., Blaxter, M. and Maizels, R. (2002) Abundant larval transcript-1 and -2 genes from Brugia malayi: diversity of genomic environments but conservation of 5 ' promoter sequences functional in Caenorhabditis elegans. Molecular and Biochemical Parasitology, 125, pp. 59-71.

Hashmi, S., Britton, C. , Liu, J., Guiliano, D., Oksov, Y. and Lustigman, S. (2002) Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. Journal of Biological Chemistry, 277, pp. 3477-3486. (doi: 10.1074/jbc.M106117200)

Thompson, F., Britton, C. , Wheatley, I., Maitland, K., Walker, G., Anant, S., Davidson, N. and Devaney, E. (2002) Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Biochemical Journal, 365, pp. 99-107.

Thompson, F., Cockroft, A., Wheatley, I., Britton, C. and Devaney, E. (2001) Heat shock and developmental expression of hsp83 in the filarial nematode Brugia pahangi. European Journal of Biochemistry, 268, pp. 5808-5815.

Britton, C. , Redmond, D. L., Knox, D. P., McKerrow, J. H. and Barry, J. D. (1999) Identification of promoter elements of parasitic nematodes in transgenic Caenorhabditis elegans. Molecular and Biochemical Parasitology, 103(2), pp. 171-181. (doi: 10.1016/S0166-6851(99)00121-8) (PMID:10551361)

Britton, C. , McKerrow, J. H. and Johnstone, I. L. (1998) Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. Journal of Molecular Biology, 283(1), pp. 15-27. (doi: 10.1006/jmbi.1998.2093) (PMID:9761670)

McCririe, L., Bairden, K., Britton, C. , Buitkamp, J., McKeand, J.B. and Stear, M.J. (1997) Heterogeneity in the recognition of Ostertagia circumcincta antigens by serum antibody from mature, infected sheep. Parasite Immunology, 19(5), pp. 235-242. (doi: 10.1046/j.1365-3024.1997.d01-202.x) (PMID:9194101)

Kennedy, M. W. , Britton, C. , Price, N. C., Kelly, S. M. and Cooper, A. (1995) The DvA-1 polyprotein of the parasitic nematode Dictyocaulus viviparus. A small helix-rich lipid-binding protein. Journal of Biological Chemistry, 270(33), pp. 19277-19281. (doi: 10.1074/jbc.270.33.19277) (PMID:7642601)

Britton, C. , Moore, J., Gilleard, J. S. and Kennedy, M. W. (1995) Extensive diversity in repeat unit sequences of the cDNA encoding the polyprotein antigen/allergen from the bovine lungworm Dictyocaulus viviparus. Molecular and Biochemical Parasitology, 72(1-2), pp. 77-88. (doi: 10.1016/0166-6851(95)00088-I) (PMID:8538702)

Britton, C. , Knox, D.P. and Kennedy, M.W. (1994) Superoxide dismutase (SOD) activity of Dictyocaulus viviparus and its inhibition by antibody from infected and vaccinated bovine hosts. Parasitology, 109(2), pp. 257-263. (doi: 10.1017/s0031182000076381) (PMID:8084670)

Britton, C. , Canto, G. J., Urquhart, G. M. and Kennedy, M. W. (1993) Stage-specific surface antigens of the cattle lungworm Dictyocaulus viviparus. Parasite Immunology, 15(11), pp. 625-634. (doi: 10.1111/j.1365-3024.1993.tb00576.x) (PMID:7877839)

Britton, C. , Canto, G., Urquhart, G. M. and Kennedy, M. W. (1993) Characterization of excretory-secretory products of adult Dictyocaulus viviparus and the antibody response to them in infection and vaccination. Parasite Immunology, 15(3), pp. 163-174. (doi: 10.1111/j.1365-3024.1993.tb00596.x) (PMID:8316410)

Britton, C. , Knox, D.P., Canto, G.J., Urquhart, G.M. and Kennedy, M.W. (1992) The secreted and somatic proteinases of the bovine lungworm Dictyocaulus viviparus and their inhibition by antibody from infected and vaccinated animals. Parasitology, 105(2), pp. 325-333. (doi: 10.1017/s0031182000074254) (PMID:1454428)

Britton, C. , Canto, G. J., Urquhart, G. M. and Kennedy, M. W. (1992) The antibody repertoire in infection and vaccination with Dictyocaulus viviparus: heterogeneity in infected cattle and genetic control in guinea pigs. Veterinary Immunology and Immunopathology, 31(3-4), pp. 313-322. (doi: 10.1016/0165-2427(92)90018-L) (PMID:1534189)

Book Sections

Britton, C. (2013) Proteases of nematodes: from free-living to parasite. In: Kennedy, M.W. and Harnett, W. (eds.) Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology. Cabi Publishing, pp. 354-374. ISBN 9781845937591 (doi: 10.1079/9781845937591.0351)

Caffrey, C.R., Britton, C. and McKerrow, J.H. (2013) Helminth cysteine proteases. In: Rawlings, N.D. and Salvesen, G. (eds.) Handbook of Proteolytic Enzymes. Elsevier Science, pp. 1949-1957. ISBN 9780123822192 (doi: 10.1016/B978-0-12-382219-2.00444-0)

Britton, C. (2012) RNA interference: A potential discovery tool for therapeutic targets of parasitic nematodes. In: Parasitic helminths: Targets, screens, drugs and vaccines. Wiley-Blackwell, pp. 89-103.

Book Reviews

Britton, C. (2015) Ascaris: The Neglected Parasite, by Celia Holland. Parasitology, 142(4), p. 633. (doi: 10.1017/S0031182014001541)[Book Review]

Conference or Workshop Item

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

Perez, M. , Gillan, V. , Devaney, E. and Britton, C. (2023) Parasitic Nematode miRNAs and EVs - Transfection into Organoid Epithelial Cells [Poster]. Challenges, Opportunities, and New Technologies for Functional Validation of Parasitic Nematode Genes, University of Glasgow, Glasgow UK, March 2023.

Perez, M. G. , Gillan, V. , Maitland, K. , Devaney, E. and Britton, C. (2022) microRNAs in Gastrointestinal Nematode-host Interactions [Poster]. Hydra 2022, Hydra, Greece, 28 Aug-2 Sept 2022.

Britton, C. , Knox, D. P. and Kennedy, M. W. (1993) Excretory-Secretory Superoxide Dismutase (SOD) of the Bovine Lungworm Dictyocaulus Viviparus. Molecular Helminthology: An Integrated Approach, Tamarron, Colorado, USA, 10-17 Feb 1993. (doi: 10.1002/jcb.240530704)