Dr Tom Van Agtmael

  • Senior Lecturer (Institute of Cardiovascular & Medical Sciences)
  • Associate (Institute of Molecular Cell & Systems Biology)
  • Associate (School of Life Sciences)

Biography

Following his undergraduate training in Biochemistry at the University of Antwerp (Belgium), Dr. Van Agtmael obtained his PhD in molecular genetics at the Murdoch Childrens Research Institute in Melbourne (Australia). He then moved to the MRC Human Genetics Unit in Edinburgh for his post-doctoral training as an EU Marie Curie Fellow during which he identified the first vertebrate Col4a1 mutations and implicated type IV collagen in eye and kidney disease. Following a CVRI Wellcome Trust Fellowship at the University of Edinburgh, he was awarded a MRC New Investigator Research Grant to investigate the role of collagen IV in vascular biology. He then joined the University of Glasgow as a RCUK Fellow in Human Molecular Genetics where he established his research group within the Institute of Cardiovascular and Medical Sciences.


Research interests

Member: Vascular Research

My research focuses on identifying molecular mechanisms that cause intracerebral haemorrhage, stroke, eye and kidney disease. Role of the extracellular matrix and collagen IV in health and disease.

Research: Basement membranes and human disease

 


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Elucidation of molecular pathways underlying cardiac disease caused by Col4a1 mutations
    Heart Research UK
    2018 - 2021
     
  • Developing MRI methods to Detect Subtle Changes in Blood Brain Barrier Permeability
    Neurosciences Foundation
    2018 - 2019
     
  • Collagen IV variants and their role in intracerebral haemorrhage in the general population
    Medical Research Council
    2018 - 2021
     
  • Disintegration of the cerebral matrisome: a central mechanism leading to small vessel disease and vascular cognitive impairment
    Stroke Association
    2017 - 2021
     
  • Targeting intracellular pathways to dissect mechanisms of cerebrovascular disease.
    British Heart Foundation
    2016 - 2019
     
  • Using C. elegans to identify novel genetic modifiers of collagen IV mutations that cause stroke
    Tenovus Scotland
    2015 - 2015
     
  • A polyomics based approach to identify molecular pathways and genetic modifiers which influence the development of stroke caused by collagen IV mutations (ISSF)
    Wellcome Trust
    2013 - 2014
     
  • Elucidation of molecular pathways underlying renal disease caused by Co/4a 1 mutations using mouse models.
    Kidney Research UK
    2013 - 2015
     
  • New Investigator Research Grant
    Medical Research Council
    2007 - 2010
     
  • RCUK Academic Fellowship - IBLS
    Engineering and Physical Sciences Research Council
    2007 - 2012
     

Additional information

Invited International Presentations

  • 2012: Melbourne, Australia - Invited seminar speaker, Faculty of Medicine, Northern Hospital, University of Melbourne
  • 2012: Melbourne, Australia - Invited seminar speaker, Murdoch Childrens Research Institute
  • 2012: Oxford, England, UK - Joint Meeting of the British and German Societies for Matrix Biology
  • 2011: Brussels, Belgium - Invited seminar speaker, Department of Medical Genetics Université Libre de Bruxelles - Erasmus Hospital
  • 2011: Scottish Society for Experimental Medicine
  • 2011: Leicester, England, UK - Invited seminar speaker, Cardiovascular Research Theme, University of Leicester
  • 2011: Bristol, England, UK - Invited seminar speaker, Department of Paediatric Neurology, Royal Hospital for Sick Children
  • 2011: Southampton, England, UK - Invited seminar speaker, Department of Medical Genetics, University of Southampton
  • 2010: Manchester, England, UK - British Society Matrix Biology Meeting
  • 2009: New Hampshire, USA - Invited speaker at the Collagen Gordon Conference
  • 2007: Oulu, Finland - Invited speaker, Biocenter Day University of Oulu
  • 2007: Paris, France - Invited seminar speaker, INSERM Unit, Tenon Hospital, Department of Nephrology
  • 2006: Manchester, England, UK - Invited seminar speaker, Wellcome Trust Centre for Cell-Matrix Biology
  • 2006: Glasgow, Scotland, UK - Invited speaker at the ERA-EDTA (European Renal Association) Conference
  • 2005: New Hampshire, USA - Invited speaker at the Collagen Gordon Conference
  • 2005: Paris, France - Invited seminar speaker, INSERM Unit, Tenon Hospital, Department of Nephrology
  • 2005: Strasbourg, France - International Mouse Genome Conference
  • 2004: Rhode Island, USA - Invited speaker at the Basement Membrane Gordon Conference

Professional Learned Society

  • 2012 - present: British Society for Matrix Biology - Committee Member
  • 2011 - present: Genetics Society - Member
  • 2010 - present: British Society for Matrix Biology - Member
  • 2007 - present: International Society of Matrix Biology - Member

Research Fellowship

  • 2007 - 2012: Research Councils UK Academic Fellowship
  • 2004 - 2007: Wellcome Trust CVRI Fellow
  • 2002 - 2004: EU Marie Curie Fellow

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2011 | 2010 | 2009 | 2007 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 18.

2018

Jones, F. E. et al. (2018) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Human Molecular Genetics, (doi:10.1093/hmg/ddy369) (PMID:30351356) (Early Online Publication)

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi:10.1042/CS20171620) (PMID:29712883)

2017

Wang, D., Mohammad, M., Wang, Y., Tan, R., Murray, L. S., Ricardo, S., Dagher, H., van Agtmael, T. and Savige, J. (2017) The chemical chaperone, PBA, reduces ER stress and autophagy and increases collagen IV α5 expression in cultured fibroblasts from men with X-linked Alport syndrome and missense mutations. Kidney International Reports, 2(4), pp. 739-748. (doi:10.1016/j.ekir.2017.03.004)

2016

Verdura, E. et al. (2016) Disruption of a miR-29 binding site leading to COL4A1 upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy. Annals of Neurology, 80(5), pp. 741-753. (doi:10.1002/ana.24782) (PMID:27666438)

Jones, F. E. et al. (2016) ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice. Disease Models and Mechanisms, 9(2), pp. 165-76. (doi:10.1242/dmm.021741) (PMID:26839400) (PMCID:PMC4770143)

2015

Rannikmäe, K. et al. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84(9), pp. 918-926. (doi:10.1212/WNL.0000000000001309) (PMID:25653287) (PMCID:PMC4351667)

2014

Husi, H., Van Agtmael, T. , Mullen, W. , Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C. , Perco, P. and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi:10.1161/CIRCGENETICS.113.000196)

Murray, L.S., Lu, Y., Taggart, A., Van Regemorter, N., Vilain, C., Abramowicz, M., Kadler, K.E. and Van Agtmael, T. (2014) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke. Human Molecular Genetics, 23(2), pp. 283-292. (doi:10.1093/hmg/ddt418) (PMID:24001601) (PMCID:PMC3869351)

2011

Agarwal, S., Taylor, S.H., Al-Youha, S., Van Agtmael, T. , Lu, Y., Wong, J., McGrouther, D.A. and Kadler, K.E. (2011) Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE, 6(1), e16337. (doi:10.1371/journal.pone.0016337)

2010

Van Agtmael, T. , Bailey, M. A., Schlotzer-Schrehardt, U., Craigie, E., Jackson, I. J., Brownstein, D. G., Megson, I. L. and Mullins, J. J. (2010) Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume. Human Molecular Genetics, 19(6), pp. 1119-1128. (doi:10.1093/hmg/ddp584)

Van Agtmael, T. and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339(1), pp. 167-188. (doi:10.1007/s00441-009-0866-y)

2009

Alamowitch, S., Plaisier, E., Favrole, P., Prost, C., Chen, Z., Van Agtmael, T. , Marro, B. and Ronco, P. (2009) Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. Neurology, 73(22), pp. 1873-1882. (doi:10.1212/WNL.0b013e3181c3fd12)

2007

Plaisier, E. et al. (2007) COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. New England Journal of Medicine, 357(26), pp. 2687-2695. (doi:10.1056/NEJMoa071906)

2005

Van Agtmael, T. (2005) Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Human Molecular Genetics, 14(21), pp. 3161-3168. (doi:10.1093/hmg/ddi348)

2004

Van Agtmael, T. (2004) 17th International Mouse Genome Conference. Mammalian Genome, 15(7), pp. 509-514. (doi:10.1007/s00335-004-4001-9)

2003

Van Agtmael, T. (2003) Parametric and nonparametric genome scan analyses for human handedness. European Journal of Human Genetics, 11(10), pp. 779-783. (doi:10.1038/sj.ejhg.5201048)

2002

Van Agtmael, T. (2002) Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness. European Journal of Human Genetics, 10(10), pp. 623-630. (doi:10.1038/sj.ejhg.5200851)

2001

Van Agtmael, T. (2001) Genes for left-handedness: How to search for the needle in the haystack? Laterality, 6(2), pp. 149-164. (doi:10.1080/713754403)

This list was generated on Mon May 20 20:24:37 2019 BST.
Jump to: Articles
Number of items: 18.

Articles

Jones, F. E. et al. (2018) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Human Molecular Genetics, (doi:10.1093/hmg/ddy369) (PMID:30351356) (Early Online Publication)

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi:10.1042/CS20171620) (PMID:29712883)

Wang, D., Mohammad, M., Wang, Y., Tan, R., Murray, L. S., Ricardo, S., Dagher, H., van Agtmael, T. and Savige, J. (2017) The chemical chaperone, PBA, reduces ER stress and autophagy and increases collagen IV α5 expression in cultured fibroblasts from men with X-linked Alport syndrome and missense mutations. Kidney International Reports, 2(4), pp. 739-748. (doi:10.1016/j.ekir.2017.03.004)

Verdura, E. et al. (2016) Disruption of a miR-29 binding site leading to COL4A1 upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy. Annals of Neurology, 80(5), pp. 741-753. (doi:10.1002/ana.24782) (PMID:27666438)

Jones, F. E. et al. (2016) ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice. Disease Models and Mechanisms, 9(2), pp. 165-76. (doi:10.1242/dmm.021741) (PMID:26839400) (PMCID:PMC4770143)

Rannikmäe, K. et al. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84(9), pp. 918-926. (doi:10.1212/WNL.0000000000001309) (PMID:25653287) (PMCID:PMC4351667)

Husi, H., Van Agtmael, T. , Mullen, W. , Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C. , Perco, P. and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi:10.1161/CIRCGENETICS.113.000196)

Murray, L.S., Lu, Y., Taggart, A., Van Regemorter, N., Vilain, C., Abramowicz, M., Kadler, K.E. and Van Agtmael, T. (2014) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke. Human Molecular Genetics, 23(2), pp. 283-292. (doi:10.1093/hmg/ddt418) (PMID:24001601) (PMCID:PMC3869351)

Agarwal, S., Taylor, S.H., Al-Youha, S., Van Agtmael, T. , Lu, Y., Wong, J., McGrouther, D.A. and Kadler, K.E. (2011) Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE, 6(1), e16337. (doi:10.1371/journal.pone.0016337)

Van Agtmael, T. , Bailey, M. A., Schlotzer-Schrehardt, U., Craigie, E., Jackson, I. J., Brownstein, D. G., Megson, I. L. and Mullins, J. J. (2010) Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume. Human Molecular Genetics, 19(6), pp. 1119-1128. (doi:10.1093/hmg/ddp584)

Van Agtmael, T. and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339(1), pp. 167-188. (doi:10.1007/s00441-009-0866-y)

Alamowitch, S., Plaisier, E., Favrole, P., Prost, C., Chen, Z., Van Agtmael, T. , Marro, B. and Ronco, P. (2009) Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. Neurology, 73(22), pp. 1873-1882. (doi:10.1212/WNL.0b013e3181c3fd12)

Plaisier, E. et al. (2007) COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. New England Journal of Medicine, 357(26), pp. 2687-2695. (doi:10.1056/NEJMoa071906)

Van Agtmael, T. (2005) Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Human Molecular Genetics, 14(21), pp. 3161-3168. (doi:10.1093/hmg/ddi348)

Van Agtmael, T. (2004) 17th International Mouse Genome Conference. Mammalian Genome, 15(7), pp. 509-514. (doi:10.1007/s00335-004-4001-9)

Van Agtmael, T. (2003) Parametric and nonparametric genome scan analyses for human handedness. European Journal of Human Genetics, 11(10), pp. 779-783. (doi:10.1038/sj.ejhg.5201048)

Van Agtmael, T. (2002) Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness. European Journal of Human Genetics, 10(10), pp. 623-630. (doi:10.1038/sj.ejhg.5200851)

Van Agtmael, T. (2001) Genes for left-handedness: How to search for the needle in the haystack? Laterality, 6(2), pp. 149-164. (doi:10.1080/713754403)

This list was generated on Mon May 20 20:24:37 2019 BST.


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