Dr Tom Van Agtmael

Senior Lecturer (Institute of Cardiovascular & Medical Sciences)
Associate (Institute of Molecular Cell & Systems Biology)
Associate (School of Life Sciences)

telephone: 01413306200
email: Tom.VanAgtmael@glasgow.ac.uk

ORCID iD https://orcid.org/0000-0003-4282-449X

Biography

Following his undergraduate training in Biochemistry at the University of Antwerp (Belgium), Dr. Van Agtmael obtained his PhD in molecular genetics at the Murdoch Childrens Research Institute in Melbourne (Australia). He then moved to the MRC Human Genetics Unit in Edinburgh for his post-doctoral training as an EU Marie Curie Fellow during which he identified the first vertebrate Col4a1 mutations and implicated type IV collagen in eye and kidney disease. Following a CVRI Wellcome Trust Fellowship at the University of Edinburgh, he was awarded a MRC New Investigator Research Grant to investigate the role of collagen IV in vascular biology. He then joined the University of Glasgow as a RCUK Fellow in Human Molecular Genetics where he established his research group within the Institute of Cardiovascular and Medical Sciences.

Research interests

Member: Vascular Research

My research focuses on identifying molecular mechanisms that cause intracerebral haemorrhage, stroke, eye and kidney disease. Role of the extracellular matrix and collagen IV in health and disease.

Research: Basement membranes and human disease

Publications

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Number of items: 20.

2020

Ngandu Mpoyi, E. et al. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, 120090. (doi: 10.1016/j.biomaterials.2020.120090) (PMID:32413593)

2019

Gatseva, A., Sin, Y. Y., Brezzo, G. and Van Agtmael, T. (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63(3), pp. 297-312. (doi: 10.1042/EBC20180071) (PMID:31387942) (PMCID:PMC6744580)

Jones, F. E. et al. (2019) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Human Molecular Genetics, 28(4), pp. 628-638. (doi: 10.1093/hmg/ddy369) (PMID:30351356) (PMCID:PMC6360271)

2018

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi: 10.1042/CS20171620) (PMID:29712883)

2017

Wang, D., Mohammad, M., Wang, Y., Tan, R., Murray, L. S., Ricardo, S., Dagher, H., van Agtmael, T. and Savige, J. (2017) The chemical chaperone, PBA, reduces ER stress and autophagy and increases collagen IV α5 expression in cultured fibroblasts from men with X-linked Alport syndrome and missense mutations. Kidney International Reports, 2(4), pp. 739-748. (doi: 10.1016/j.ekir.2017.03.004)

2016

Verdura, E. et al. (2016) Disruption of a miR-29 binding site leading to COL4A1 upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy. Annals of Neurology, 80(5), pp. 741-753. (doi: 10.1002/ana.24782) (PMID:27666438)

Jones, F. E. et al. (2016) ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice. Disease Models and Mechanisms, 9(2), pp. 165-76. (doi: 10.1242/dmm.021741) (PMID:26839400) (PMCID:PMC4770143)

2015

Rannikmäe, K. et al. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84(9), pp. 918-926. (doi: 10.1212/WNL.0000000000001309) (PMID:25653287) (PMCID:PMC4351667)

2014

Husi, H., Van Agtmael, T. , Mullen, W. , Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C. , Perco, P. and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi: 10.1161/CIRCGENETICS.113.000196)

Murray, L.S., Lu, Y., Taggart, A., Van Regemorter, N., Vilain, C., Abramowicz, M., Kadler, K.E. and Van Agtmael, T. (2014) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke. Human Molecular Genetics, 23(2), pp. 283-292. (doi: 10.1093/hmg/ddt418) (PMID:24001601) (PMCID:PMC3869351)

2011

Agarwal, S., Taylor, S.H., Al-Youha, S., Van Agtmael, T. , Lu, Y., Wong, J., McGrouther, D.A. and Kadler, K.E. (2011) Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE, 6(1), e16337. (doi: 10.1371/journal.pone.0016337)

2010

Van Agtmael, T. , Bailey, M. A., Schlotzer-Schrehardt, U., Craigie, E., Jackson, I. J., Brownstein, D. G., Megson, I. L. and Mullins, J. J. (2010) Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume. Human Molecular Genetics, 19(6), pp. 1119-1128. (doi: 10.1093/hmg/ddp584)

Van Agtmael, T. and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339(1), pp. 167-188. (doi: 10.1007/s00441-009-0866-y)

2009

Alamowitch, S., Plaisier, E., Favrole, P., Prost, C., Chen, Z., Van Agtmael, T. , Marro, B. and Ronco, P. (2009) Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. Neurology, 73(22), pp. 1873-1882. (doi: 10.1212/WNL.0b013e3181c3fd12)

2007

Plaisier, E. et al. (2007) COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. New England Journal of Medicine, 357(26), pp. 2687-2695. (doi: 10.1056/NEJMoa071906)

2005

Van Agtmael, T. (2005) Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Human Molecular Genetics, 14(21), pp. 3161-3168. (doi: 10.1093/hmg/ddi348)

2004

Van Agtmael, T. (2004) 17th International Mouse Genome Conference. Mammalian Genome, 15(7), pp. 509-514. (doi: 10.1007/s00335-004-4001-9)

2003

Van Agtmael, T. (2003) Parametric and nonparametric genome scan analyses for human handedness. European Journal of Human Genetics, 11(10), pp. 779-783. (doi: 10.1038/sj.ejhg.5201048)

2002

Van Agtmael, T. (2002) Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness. European Journal of Human Genetics, 10(10), pp. 623-630. (doi: 10.1038/sj.ejhg.5200851)

2001

Van Agtmael, T. (2001) Genes for left-handedness: How to search for the needle in the haystack? Laterality, 6(2), pp. 149-164. (doi: 10.1080/713754403)

This list was generated on Tue Jul 14 12:11:35 2020 BST.

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