Dr Tom Van Agtmael
- Reader (Institute of Cardiovascular & Medical Sciences)
- Associate (Institute of Molecular Cell & Systems Biology)
- Associate (School of Life Sciences)
telephone:
01413306200
email:
Tom.VanAgtmael@glasgow.ac.uk
R423 Level 4, Institute of C&MS, Davidson Building, Glasgow G12 8QQ
Biography
Following his undergraduate training in Biochemistry at the University of Antwerp (Belgium), Dr. Van Agtmael obtained his PhD in molecular genetics at the Murdoch Childrens Research Institute in Melbourne (Australia). He then moved to the MRC Human Genetics Unit in Edinburgh for his post-doctoral training as an EU Marie Curie Fellow during which he identified the first vertebrate Col4a1 mutations and implicated type IV collagen in eye and kidney disease. Following a CVRI Wellcome Trust Fellowship at the University of Edinburgh, he was awarded a MRC New Investigator Research Grant to investigate the role of collagen IV in vascular biology. He then joined the University of Glasgow as a RCUK Fellow in Human Molecular Genetics where he established his research group within the Institute of Cardiovascular and Medical Sciences.
Research interests
Member: Vascular Research
My research focuses on identifying molecular mechanisms that cause intracerebral haemorrhage, stroke, eye and kidney disease. Role of the extracellular matrix and collagen IV in health and disease.
Research: Basement membranes and human disease
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Elucidation of molecular pathways underlying cardiac disease caused by Col4a1 mutations
Heart Research UK
2018 - 2021
- Developing MRI methods to Detect Subtle Changes in Blood Brain Barrier Permeability
Neurosciences Foundation
2018 - 2019
- Collagen IV variants and their role in intracerebral haemorrhage in the general population
Medical Research Council
2018 - 2021
- Disintegration of the cerebral matrisome: a central mechanism leading to small vessel disease and vascular cognitive impairment
Stroke Association
2017 - 2021
- Targeting intracellular pathways to dissect mechanisms of cerebrovascular disease.
British Heart Foundation
2016 - 2019
- Using C. elegans to identify novel genetic modifiers of collagen IV mutations that cause stroke
Tenovus Scotland
2015 - 2015
- A polyomics based approach to identify molecular pathways and genetic modifiers which influence the development of stroke caused by collagen IV mutations (ISSF)
Wellcome Trust
2013 - 2014
- Elucidation of molecular pathways underlying renal disease caused by Co/4a 1 mutations using mouse models.
Kidney Research UK
2013 - 2015
- New Investigator Research Grant
Medical Research Council
2007 - 2010
- RCUK Academic Fellowship - IBLS
Engineering and Physical Sciences Research Council
2007 - 2012
Additional information
Invited International Presentations
- 2012: Melbourne, Australia - Invited seminar speaker, Faculty of Medicine, Northern Hospital, University of Melbourne
- 2012: Melbourne, Australia - Invited seminar speaker, Murdoch Childrens Research Institute
- 2012: Oxford, England, UK - Joint Meeting of the British and German Societies for Matrix Biology
- 2011: Brussels, Belgium - Invited seminar speaker, Department of Medical Genetics Université Libre de Bruxelles - Erasmus Hospital
- 2011: Scottish Society for Experimental Medicine
- 2011: Leicester, England, UK - Invited seminar speaker, Cardiovascular Research Theme, University of Leicester
- 2011: Bristol, England, UK - Invited seminar speaker, Department of Paediatric Neurology, Royal Hospital for Sick Children
- 2011: Southampton, England, UK - Invited seminar speaker, Department of Medical Genetics, University of Southampton
- 2010: Manchester, England, UK - British Society Matrix Biology Meeting
- 2009: New Hampshire, USA - Invited speaker at the Collagen Gordon Conference
- 2007: Oulu, Finland - Invited speaker, Biocenter Day University of Oulu
- 2007: Paris, France - Invited seminar speaker, INSERM Unit, Tenon Hospital, Department of Nephrology
- 2006: Manchester, England, UK - Invited seminar speaker, Wellcome Trust Centre for Cell-Matrix Biology
- 2006: Glasgow, Scotland, UK - Invited speaker at the ERA-EDTA (European Renal Association) Conference
- 2005: New Hampshire, USA - Invited speaker at the Collagen Gordon Conference
- 2005: Paris, France - Invited seminar speaker, INSERM Unit, Tenon Hospital, Department of Nephrology
- 2005: Strasbourg, France - International Mouse Genome Conference
- 2004: Rhode Island, USA - Invited speaker at the Basement Membrane Gordon Conference
Professional Learned Society
- 2012 - present: British Society for Matrix Biology - Committee Member
- 2011 - present: Genetics Society - Member
- 2010 - present: British Society for Matrix Biology - Member
- 2007 - present: International Society of Matrix Biology - Member
Research Fellowship
- 2007 - 2012: Research Councils UK Academic Fellowship
- 2004 - 2007: Wellcome Trust CVRI Fellow
- 2002 - 2004: EU Marie Curie Fellow