2018

Colman, M. A., Saxena, P., Kettlewell, S. and Workman, A. J. (2018) Description of the human atrial action potential derived from a single, congruent data source: novel computational models for integrated experimental-numerical study of atrial arrhythmia mechanisms. Frontiers in Physiology, (Accepted for Publication)

2016

Pandit, S. V. and Workman, A. (2016) Atrial electrophysiological remodeling and fibrillation in heart failure. Clinical Medicine Insights: Cardiology, 10(Sup 1), pp. 41-46. (doi:10.4137/CMC.S39713) (PMID:27812293) (PMCID:PMC5089851)

Colman, M. A., Sarathy, P. P., MacQuiaide, N. and Workman, A. J. (2016) A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation. Computing in Cardiology, 43, pp. 221-224.

2015

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. and Zhang, H. (2015) A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems: insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), e1004026. (doi:10.1371/journal.pcbi.1004026) (PMID:25611350) (PMCID:PMC4303377)

2014

Marshall, G. E., Russell, J. A., Tellez, J. O., Jhund, P. S. , Currie, S., Dempster, J., Boyett, M. R., Kane, K. A., Rankin, A. C. and Workman, A. J. (2014) Erratum to: Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 466(5), p. 1021. (doi:10.1007/s00424-014-1505-3)

Kharche, S. R., Stary, T., Colman, M. A., Biktasheva, I. V., Workman, A. J., Rankin, A. C., Holden, A. V. and Zhang, H. (2014) Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of AF: a computer simulation. Europace, 16(10), pp. 1524-1533. (doi:10.1093/europace/euu084)

2013

Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087) (PMCID:PMC3687753)

2012

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L. and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi:10.1113/jphysiol.2012.235986)

Grandi, E., Workman, A.J. and Pandit, S.V. (2012) Altered excitation-contraction coupling in human chronic atrial fibrillation. Journal of Atrial Fibrillation, 2(10), pp. 1-17.

Marshall, G.E., Russell, J.A., Tellez, J.O., Jhund, P.S. , Currie, S., Dempster, J., Boyett, M.R., Kane, K.A., Rankin, A.C. and Workman, A.J. (2012) Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 463(4), pp. 537-548. (doi:10.1007/s00424-011-1061-z)

2011

Pandit, S.V. et al. (2011) Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs. Cardiovascular Research, 89(4), pp. 843-851. (doi:10.1093/cvr/cvq359)

Grandi, E., Pandit, S.V., Voigt, N., Workman, A.J., Dobrev, D., Jalife, J. and Bers, D.M. (2011) Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation Research, 109(9), pp. 1055-1066. (doi:10.1161/CIRCRESAHA.111.253955)

Workman, A.J., Smith, G.L. and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi:10.1016/j.pharmthera.2011.02.002)

2010

Workman, A.J. and Rankin, A.C. (2010) Do hypoxemia or hypercapnia predispose to atrial fibrillation in breathing disorders, and, if so, how? Heart Rhythm, 7(9), pp. 1271-1272. (doi:10.1016/j.hrthm.2010.04.004)

Workman, A.J. (2010) Cardiac adrenergic control and atrial fibrillation. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(3), pp. 235-249. (doi:10.1007/s00210-009-0474-0)

2009

Rankin, A.C. and Workman, A.J. (2009) Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? Cardiovascular Research, 84(2), pp. 180-181. (doi:10.1093/cvr/cvp299)

Workman, A.J. (2009) Mechanisms of postcardiac surgery atrial fibrillation: more pieces in a difficult puzzle. Heart Rhythm, 6(10), pp. 1423-1424. (doi:10.1016/j.hrthm.2009.07.031)

Workman, A.J., Pau, D., Redpath, C., Marshall, G.E., Russell, J.A., Norrie, J., Kane, K.A. and Rankin, A.C. (2009) Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF. Heart Rhythm, 6(4), pp. 445-451. (doi:10.1016/j.hrthm.2008.12.028)

2008

Workman, A.J., Kane, K. and Rankin, A.C. (2008) Cellular bases for human atrial fibrillation. Heart Rhythm, 5(6, Sup), S1-S6. (doi:10.1016/j.hrthm.2008.01.016)

2007

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2007) Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation. Journal of Molecular and Cellular Cardiology, 42(1), pp. 54-62. (doi:10.1016/j.yjmcc.2006.08.007)

2006

Workman, A.J., Pau, D., Redpath, C.J., Marshall, G.E., Russell, J.A., Kane, K.A., Norrie, J. and Rankin, A.C. (2006) Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology. Journal of Cardiovascular Electrophysiology, 17(11), pp. 1230-1238. (doi:10.1111/j.1540-8167.2006.00592.x)

Redpath, C., Rankin, A.C., Kane, K.A. and Workman, A.J. (2006) Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic. Journal of Molecular and Cellular Cardiology, 40(5), pp. 717-724. (doi:10.1016/j.yjmcc.2006.01.012)

2005

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2005) Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. Journal of Pharmacology and Experimental Therapeutics, 313, pp. 146-153. (doi:10.1124/jpet.104.076869)

2003

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade. British Journal of Pharmacology, 140, pp. 1434-1441. (doi:10.1038/sj.bjp.0705553)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation. Cardiovascular Research, 59(3), pp. 593-602. (doi:10.1016/S0008-6363(03)00466-8)

Workman, A.J., Kane, K.A., Russell, J.A., Norrie, J. and Rankin, A.C. (2003) Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. Cardiovascular Research, 58(3), pp. 518-525. (doi:10.1016/S0008-6363(03)00263-3)

2001

Workman, A.J., MacKenzie, I. and Northover, B.J. (2001) A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-83. (doi:10.1016/S0014-2999(01)00972-4)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2001) The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular Research, 52(2), pp. 226-235. (doi:10.1016/S0008-6363(01)00380-7)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2001) A K _ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-78. (doi:10.1016/S0014-2999(01)00972-4)

2000

Workman, A.J., Kane, K.A. and Rankin, A.C. (2000) Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium. Journal of Molecular and Cellular Cardiology, 32(8), pp. 1525-1537. (doi:10.1006/jmcc.2000.1186)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2000) Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? Basic Research in Cardiology, 95(3), pp. 250-260. (doi:10.1007/s003950050188)

1999

Workman, A.J., Kane, K.A. and Rankin, A.C. (1999) Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes. Cardiovascular Research, 43(4), pp. 974-984. (doi:10.1016/S0008-6363(99)00166-2)

1998

Workman, A.J. and Rankin, A.C. (1998) Serotonin, I_f and human atrial arrhythmia. Cardiovascular Research, 40(3), p. 436. (doi:10.1016/S0008-6363(98)00258-2)

1997

Rankin, A.C., Martynyuk,, A.E., Workman, A.J. and Kane, K.A. (1997) Ionic mechanisms of the effect of adenosine on single rabbit atrioventricular node myocytes. Canadian Journal of Cardiology, 13(12), pp. 1183-1187.

Articles

Colman, M. A., Saxena, P., Kettlewell, S. and Workman, A. J. (2018) Description of the human atrial action potential derived from a single, congruent data source: novel computational models for integrated experimental-numerical study of atrial arrhythmia mechanisms. Frontiers in Physiology, (Accepted for Publication)

Pandit, S. V. and Workman, A. (2016) Atrial electrophysiological remodeling and fibrillation in heart failure. Clinical Medicine Insights: Cardiology, 10(Sup 1), pp. 41-46. (doi:10.4137/CMC.S39713) (PMID:27812293) (PMCID:PMC5089851)

Colman, M. A., Sarathy, P. P., MacQuiaide, N. and Workman, A. J. (2016) A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation. Computing in Cardiology, 43, pp. 221-224.

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. and Zhang, H. (2015) A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems: insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), e1004026. (doi:10.1371/journal.pcbi.1004026) (PMID:25611350) (PMCID:PMC4303377)

Marshall, G. E., Russell, J. A., Tellez, J. O., Jhund, P. S. , Currie, S., Dempster, J., Boyett, M. R., Kane, K. A., Rankin, A. C. and Workman, A. J. (2014) Erratum to: Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 466(5), p. 1021. (doi:10.1007/s00424-014-1505-3)

Kharche, S. R., Stary, T., Colman, M. A., Biktasheva, I. V., Workman, A. J., Rankin, A. C., Holden, A. V. and Zhang, H. (2014) Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of AF: a computer simulation. Europace, 16(10), pp. 1524-1533. (doi:10.1093/europace/euu084)

Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087) (PMCID:PMC3687753)

Workman, A.J., Marshall, G.E., Rankin, A.C., Smith, G.L. and Dempster, J. (2012) Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes. Journal of Physiology, 590(17), pp. 4289-4305. (doi:10.1113/jphysiol.2012.235986)

Grandi, E., Workman, A.J. and Pandit, S.V. (2012) Altered excitation-contraction coupling in human chronic atrial fibrillation. Journal of Atrial Fibrillation, 2(10), pp. 1-17.

Marshall, G.E., Russell, J.A., Tellez, J.O., Jhund, P.S. , Currie, S., Dempster, J., Boyett, M.R., Kane, K.A., Rankin, A.C. and Workman, A.J. (2012) Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade. Pflügers Archiv - European Journal of Physiology, 463(4), pp. 537-548. (doi:10.1007/s00424-011-1061-z)

Pandit, S.V. et al. (2011) Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs. Cardiovascular Research, 89(4), pp. 843-851. (doi:10.1093/cvr/cvq359)

Grandi, E., Pandit, S.V., Voigt, N., Workman, A.J., Dobrev, D., Jalife, J. and Bers, D.M. (2011) Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation Research, 109(9), pp. 1055-1066. (doi:10.1161/CIRCRESAHA.111.253955)

Workman, A.J., Smith, G.L. and Rankin, A.C. (2011) Mechanisms of termination and prevention of atrial fibrillation by drug therapy. Pharmacology and Therapeutics, 131(2), pp. 221-241. (doi:10.1016/j.pharmthera.2011.02.002)

Workman, A.J. and Rankin, A.C. (2010) Do hypoxemia or hypercapnia predispose to atrial fibrillation in breathing disorders, and, if so, how? Heart Rhythm, 7(9), pp. 1271-1272. (doi:10.1016/j.hrthm.2010.04.004)

Workman, A.J. (2010) Cardiac adrenergic control and atrial fibrillation. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(3), pp. 235-249. (doi:10.1007/s00210-009-0474-0)

Rankin, A.C. and Workman, A.J. (2009) Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? Cardiovascular Research, 84(2), pp. 180-181. (doi:10.1093/cvr/cvp299)

Workman, A.J. (2009) Mechanisms of postcardiac surgery atrial fibrillation: more pieces in a difficult puzzle. Heart Rhythm, 6(10), pp. 1423-1424. (doi:10.1016/j.hrthm.2009.07.031)

Workman, A.J., Pau, D., Redpath, C., Marshall, G.E., Russell, J.A., Norrie, J., Kane, K.A. and Rankin, A.C. (2009) Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF. Heart Rhythm, 6(4), pp. 445-451. (doi:10.1016/j.hrthm.2008.12.028)

Workman, A.J., Kane, K. and Rankin, A.C. (2008) Cellular bases for human atrial fibrillation. Heart Rhythm, 5(6, Sup), S1-S6. (doi:10.1016/j.hrthm.2008.01.016)

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2007) Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation. Journal of Molecular and Cellular Cardiology, 42(1), pp. 54-62. (doi:10.1016/j.yjmcc.2006.08.007)

Workman, A.J., Pau, D., Redpath, C.J., Marshall, G.E., Russell, J.A., Kane, K.A., Norrie, J. and Rankin, A.C. (2006) Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology. Journal of Cardiovascular Electrophysiology, 17(11), pp. 1230-1238. (doi:10.1111/j.1540-8167.2006.00592.x)

Redpath, C., Rankin, A.C., Kane, K.A. and Workman, A.J. (2006) Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic. Journal of Molecular and Cellular Cardiology, 40(5), pp. 717-724. (doi:10.1016/j.yjmcc.2006.01.012)

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2005) Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. Journal of Pharmacology and Experimental Therapeutics, 313, pp. 146-153. (doi:10.1124/jpet.104.076869)

Pau, D., Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade. British Journal of Pharmacology, 140, pp. 1434-1441. (doi:10.1038/sj.bjp.0705553)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2003) Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation. Cardiovascular Research, 59(3), pp. 593-602. (doi:10.1016/S0008-6363(03)00466-8)

Workman, A.J., Kane, K.A., Russell, J.A., Norrie, J. and Rankin, A.C. (2003) Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. Cardiovascular Research, 58(3), pp. 518-525. (doi:10.1016/S0008-6363(03)00263-3)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2001) A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-83. (doi:10.1016/S0014-2999(01)00972-4)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2001) The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular Research, 52(2), pp. 226-235. (doi:10.1016/S0008-6363(01)00380-7)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2001) A K _ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias. European Journal of Pharmacology, 419(1), pp. 73-78. (doi:10.1016/S0014-2999(01)00972-4)

Workman, A.J., Kane, K.A. and Rankin, A.C. (2000) Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium. Journal of Molecular and Cellular Cardiology, 32(8), pp. 1525-1537. (doi:10.1006/jmcc.2000.1186)

Workman, A.J., MacKenzie, I. and Northover, B.J. (2000) Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? Basic Research in Cardiology, 95(3), pp. 250-260. (doi:10.1007/s003950050188)

Workman, A.J., Kane, K.A. and Rankin, A.C. (1999) Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes. Cardiovascular Research, 43(4), pp. 974-984. (doi:10.1016/S0008-6363(99)00166-2)

Workman, A.J. and Rankin, A.C. (1998) Serotonin, I_f and human atrial arrhythmia. Cardiovascular Research, 40(3), p. 436. (doi:10.1016/S0008-6363(98)00258-2)

Rankin, A.C., Martynyuk,, A.E., Workman, A.J. and Kane, K.A. (1997) Ionic mechanisms of the effect of adenosine on single rabbit atrioventricular node myocytes. Canadian Journal of Cardiology, 13(12), pp. 1183-1187.