Senescence and Stem Cell Heterogeneity
Dr Kristina Kirschner
- Research Fellow (Paul O'Gorman Leukaemia Research Centre)
Kristina received her Ph.D. from the University of Edinburgh characterising one of the first premature ageing mouse models. Her interest in ageing and cancer continued throughout her postdoc at the CRUK Cambridge Institute and at the Department of Haematology at the University of Cambridge, where she worked on the functional genomics of p53 in senescence and on haematopoietic stem cell ageing using single cell approaches. Kristina recently moved to the Institute of Cancer Sciences at the University of Glasgow, continuing her work in age-related haematopoietic stem cell heterogeneity and clonal hameopoiesis as a junior group leader. Another focus in the lab continues to be senescence heterogeneity. Kristina also runs the single cell advanced technologies for the Institute of Cancer Sciences.
LEUKA John Goldman Fellow 2019-2021
EHA-ASH TRTH Training Fellowship 2018
Kristina is interested in the interplay between stem cell ageing and cancer, using a variety of model systems.
Current research themes are:
- Elucidating heterogeneity in the ageing haematopoietic stem cell compartment
We combine single cell omics and metabolomics approaches to interrogate properties of aged haematopoietic stem cells in vitro and in vivo in normal haemopoiesis and myeloproliferative disease context.
- Exploring secondary senescence pathways in vitro and in vivo
By using co-culture in vitro approaches and advanced mouse models of secondary senescence, we aim to define functional differences between primary and secondary senescence.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- What is the role of secondary senescence in disease? Elucidating the role of notch signalling in secondary senescence
Academy of Medical Sciences
2020 - 2022
- Early detection of pre-leukaemic clones in the aged haematopoietic compartment using single cell approaches
2019 - 2021
- Elucidating metabolomics changes in myeloproliferative neoplasms
2019 - 2020
- heterotypic intercellular ERBB signalling in early progression of KRAS LuAd
Cancer Research UK
2019 - 2022
- Defining Epigenetic age as a novel tool for cancer grading
NHS Greater Glasgow and Clyde
2019 - 2019
- ERADICATION OF THE LEUKAEMIC CLONE IN MYELOPROLIFERATIVE NEOPLASMS
University of Manchester
2018 - 2019
- Support for Epigenetics research
Medical Research Council
2017 - 2017
- Fellowship Award:Elucidating the response of the aged transcriptome and genome to oncogenic stress in haematopoietic stem cells using single cell approaches
2016 - 2018
Kristina currently supervises Ph.D. students and M.Sc. students in the lab.
Kristina currently teaches on the M.Sc. Cancer Research & Precision Oncology programme.