Dr Julia Cordero

  • Senior Research Fellow (Epigenetics)

Biography

Julia was born and raised in Argentina as the first daughter of and Italian mother and Lebanese father. She studied Biology at the Universidad Nacional de San Luis and, in 2000, she decided to move to the United States, where she started her scientific career at Washington University in Saint Louis, first as a Research Assistant in Internal Medicine, followed by a PhD in the laboratory of Ross Cagan where she began her journey with Drosophila as a model to study tissue patterning during development.

In 2009, Julia joined the laboratory of Owen Sansom in the U.K. as a post-doctoral fellow funded by Marie Curie, EMBO fellowships to venture into the world of mice to study intestinal regeneration and cancer. In 2013, Julia received a Royal Society Dorothy Hodgkin Fellowship, which was a stepping stone into scientific independence.

Towards the end of 2014, she established her research group at the Wolfson Wohl Cancer Research Centre in Glasgow, currently funded by a Wellcome Trust/Royal Society Sir Henry Dale Fellowship.

Julia’s laboratory combines Drosophila and mouse model systems to understand the processes involved in stem cell-driven intestinal homeostasis and disease. They also study systemic roles of the intestine, the interactions between tumours and the immune system, and the impact of tumours to distant tissues in the host.

Outside of the lab, Julia enjoys travelling, physical exercise and, most of all, spending time with her children and husband.

 


Research interests

Stem cells in tissue homeostasis and transformation

Stem cells maintain tissue homeostasis by adjusting their function to micro-environmental or “niche” signals. Deregulation of such signals results in uncontrolled stem cell proliferation, which is often associated with cancer. The mechanisms mediating the interactions between stem cells and their niches are largely unknown.

The intestinal epithelium is a paradigm for the study of stem cell biology. The fruit fly Drosophila melanogaster represents an invaluable genetically tractable model system for studying conserved developmental and disease-related processes. The Drosophila adult midgut has remarkable resemblances to the mouse small intestine, including the presence of dedicated stem cells. Transcriptomic profiling of hyperplastic fly midguts reveal a high degree of conservation in the molecular events that regulate stem cell proliferation and suggest that the fly midgut could be a useful paradigm to understand the biology of multiple adult self-renewing epithelia.


My laboratory uses state-of-the-art microscopy, genetic techniques, lineage tracing analysis, tissue culture and gene expression profiling. We combine work on the Drosophila midgut and the mammalian intestine to understand how cell autonomous and niche-derived signals integrate to regulate stem cell proliferation in response to damage as well as tumourigenesis of adult self-renewing tissues.


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2009
Number of items: 23.

2019

Parvy, J.-P., Yu, Y., Dostalova, A., Kondo, S., Kurjan, A., Bulet, P., Lemaitre, B., Vidal, M. and Cordero, J. B. (2019) The antimicrobial peptide Defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila. eLife, 8, e45061. (doi:10.7554/eLife.45061) (PMID:31358113) (PMCID:PMC6667213)

Johansson, J. et al. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, (doi:10.1016/j.stem.2019.02.002) (PMID:30853556) (Early Online Publication)

Scopelliti, A., Bauer, C. , Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J. , Vidal, M., Maddocks, O. D.K. and Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29(2), 269-284.e10. (doi:10.1016/j.cmet.2018.09.021) (PMID:30344016) (PMCID:PMC6370946)

2018

Parvy, J.-P., Hodgson, J. A. and Cordero, J. B. (2018) Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death. BioMed Research International, 2018, 7152962. (doi:10.1155/2018/7152962) (PMID:29725601) (PMCID:PMC5872677)

Perochon, J. , Carroll, L. and Cordero, J. (2018) Wnt signalling in intestinal stem cells: lessons from mice and flies. Genes, 9(3), 138. (doi:10.3390/genes9030138) (PMID:29498662)

2017

Tian, A. et al. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13(7), e1006870. (doi:10.1371/journal.pgen.1006870) (PMID:28708826) (PMCID:PMC5510812)

2016

Scopelliti, A., Bauer, C. , Cordero, J. B. and Vidal, M. (2016) Bursicon-α subunit modulates dLGR2 activity in the adultDrosophila melanogastermidgut independently to Bursicon-β. Cell Cycle, 15(12), pp. 1538-1544. (doi:10.1080/15384101.2015.1121334) (PMID:27191973) (PMCID:PMC4934083)

Naszai, M. and Cordero, J. (2016) Intestinal stem cells: got calcium? Current Biology, 26(3), R117-R119. (doi:10.1016/j.cub.2015.12.012) (PMID:26859268)

Elbediwy, A. et al. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. (doi:10.1242/dev.133728) (PMID:26989177) (PMCID:PMC4874484)

2015

Naszai, M. , Carroll, L. and Cordero, J. (2015) Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut. Insect Biochemistry and Molecular Biology, 67, pp. 9-14. (doi:10.1016/j.ibmb.2015.05.016) (PMID:26024801)

Faller, W. et al. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature, 517(7535), pp. 497-500. (doi:10.1038/nature13896) (PMID:25383520) (PMCID:PMC4304784)

2014

Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J. and Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Current Biology, 24(11), pp. 1199-1211. (doi:10.1016/j.cub.2014.04.007)

Valeri, N. et al. (2014) microRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell, 25(4), pp. 469-483. (doi:10.1016/j.ccr.2014.03.006)

Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi:10.1136/gutjnl-2012-303883)

Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M., Muller, W. J., Vidal, M. and Sansom, O. J. (2014) c-Src drives intestinal regeneration and transformation. EMBO Journal, 33(3), pp. 1474-1491. (doi:10.1002/embj.201387454)

2013

Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi:10.1016/j.stem.2013.04.006)

Radulescu, S. et al. (2013) Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene, 32(16), pp. 2048-2057. (doi:10.1038/onc.2012.224)

Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J. and Cordero, J.B. (2013) Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle, 12(18), pp. 2973-2977. (doi:10.4161/cc.26031)

2012

Cordero, J. B., Stefanatos, R. K., Myant, K., Vidal, M. and Sansom, O. J. (2012) Non-autonomous crosstalk between the Jak/Stat and EGFR pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development, 139(24), pp. 4524-4535. (doi:10.1242/dev.078261)

Cordero, J.B. and Sansom, O.J. (2012) Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiologica, 204(1), pp. 137-143. (doi:10.1111/j.1748-1716.2011.02288.x)

Cordero, J. B., Stefanatos, R. K., Scopelliti, A., Vidal, M. and Sansom, O. J. (2012) Inducible progenitor-derived wingless regulates adult midgut regeneration in drosophila. EMBO Journal, 31(19), pp. 3901-3917. (doi:10.1038/emboj.2012.248)

2010

Cordero, J.B., Macagno, J.P., Stefanatos, R.K., Strathdee, K.E., Cagan, R.L. and Vidal, M. (2010) Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Developmental Cell, 18(6), pp. 999-1011. (doi:10.1016/j.devcel.2010.05.014)

2009

Cordero, J. B., Vidal, M. and Sansom, O. J. (2009) APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates. Cell Cycle, 8(18), pp. 2927-2931. (doi:10.4161/cc.8.18.9472)

This list was generated on Thu Dec 5 04:45:46 2019 GMT.
Jump to: Articles
Number of items: 23.

Articles

Parvy, J.-P., Yu, Y., Dostalova, A., Kondo, S., Kurjan, A., Bulet, P., Lemaitre, B., Vidal, M. and Cordero, J. B. (2019) The antimicrobial peptide Defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila. eLife, 8, e45061. (doi:10.7554/eLife.45061) (PMID:31358113) (PMCID:PMC6667213)

Johansson, J. et al. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, (doi:10.1016/j.stem.2019.02.002) (PMID:30853556) (Early Online Publication)

Scopelliti, A., Bauer, C. , Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J. , Vidal, M., Maddocks, O. D.K. and Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29(2), 269-284.e10. (doi:10.1016/j.cmet.2018.09.021) (PMID:30344016) (PMCID:PMC6370946)

Parvy, J.-P., Hodgson, J. A. and Cordero, J. B. (2018) Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death. BioMed Research International, 2018, 7152962. (doi:10.1155/2018/7152962) (PMID:29725601) (PMCID:PMC5872677)

Perochon, J. , Carroll, L. and Cordero, J. (2018) Wnt signalling in intestinal stem cells: lessons from mice and flies. Genes, 9(3), 138. (doi:10.3390/genes9030138) (PMID:29498662)

Tian, A. et al. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13(7), e1006870. (doi:10.1371/journal.pgen.1006870) (PMID:28708826) (PMCID:PMC5510812)

Scopelliti, A., Bauer, C. , Cordero, J. B. and Vidal, M. (2016) Bursicon-α subunit modulates dLGR2 activity in the adultDrosophila melanogastermidgut independently to Bursicon-β. Cell Cycle, 15(12), pp. 1538-1544. (doi:10.1080/15384101.2015.1121334) (PMID:27191973) (PMCID:PMC4934083)

Naszai, M. and Cordero, J. (2016) Intestinal stem cells: got calcium? Current Biology, 26(3), R117-R119. (doi:10.1016/j.cub.2015.12.012) (PMID:26859268)

Elbediwy, A. et al. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. (doi:10.1242/dev.133728) (PMID:26989177) (PMCID:PMC4874484)

Naszai, M. , Carroll, L. and Cordero, J. (2015) Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut. Insect Biochemistry and Molecular Biology, 67, pp. 9-14. (doi:10.1016/j.ibmb.2015.05.016) (PMID:26024801)

Faller, W. et al. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature, 517(7535), pp. 497-500. (doi:10.1038/nature13896) (PMID:25383520) (PMCID:PMC4304784)

Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J. and Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Current Biology, 24(11), pp. 1199-1211. (doi:10.1016/j.cub.2014.04.007)

Valeri, N. et al. (2014) microRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell, 25(4), pp. 469-483. (doi:10.1016/j.ccr.2014.03.006)

Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi:10.1136/gutjnl-2012-303883)

Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M., Muller, W. J., Vidal, M. and Sansom, O. J. (2014) c-Src drives intestinal regeneration and transformation. EMBO Journal, 33(3), pp. 1474-1491. (doi:10.1002/embj.201387454)

Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi:10.1016/j.stem.2013.04.006)

Radulescu, S. et al. (2013) Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene, 32(16), pp. 2048-2057. (doi:10.1038/onc.2012.224)

Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J. and Cordero, J.B. (2013) Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle, 12(18), pp. 2973-2977. (doi:10.4161/cc.26031)

Cordero, J. B., Stefanatos, R. K., Myant, K., Vidal, M. and Sansom, O. J. (2012) Non-autonomous crosstalk between the Jak/Stat and EGFR pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development, 139(24), pp. 4524-4535. (doi:10.1242/dev.078261)

Cordero, J.B. and Sansom, O.J. (2012) Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiologica, 204(1), pp. 137-143. (doi:10.1111/j.1748-1716.2011.02288.x)

Cordero, J. B., Stefanatos, R. K., Scopelliti, A., Vidal, M. and Sansom, O. J. (2012) Inducible progenitor-derived wingless regulates adult midgut regeneration in drosophila. EMBO Journal, 31(19), pp. 3901-3917. (doi:10.1038/emboj.2012.248)

Cordero, J.B., Macagno, J.P., Stefanatos, R.K., Strathdee, K.E., Cagan, R.L. and Vidal, M. (2010) Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Developmental Cell, 18(6), pp. 999-1011. (doi:10.1016/j.devcel.2010.05.014)

Cordero, J. B., Vidal, M. and Sansom, O. J. (2009) APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates. Cell Cycle, 8(18), pp. 2927-2931. (doi:10.4161/cc.8.18.9472)

This list was generated on Thu Dec 5 04:45:46 2019 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Drosophila as a model to study mechanisms of cancer-driven behavioural changes
    Cancer Research UK
    2019 - 2021
     
  • Regulation of stem cell function during tissue homeostasis and transformation
    Wellcome Trust
    2015 - 2021
     
  • Dorothy Hodgkin Fellowship
    The Royal Society
    2013 - 2018
     

Research datasets

Additional information

Research Fellowship

  • 2013 - 2018: University of Glasgow - Leadership Fellowship
  • 2013 - 2018: Royal Society Dorothy Hodgkin Fellowship