Professor Robert Jones

  • Professor of Clinical Cancer Research (Clinical Trials Research)

Publications

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Number of items: 107.

2020

Pritchard, J. J.G., Hamilton, G., Hurst, C. D., Fraser, S., Orange, C., Knowles, M. A., Jones, R. J. , Leung, H. Y. and Iwata, T. (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, (Accepted for Publication)

Dobbin, S. J.H. et al. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, (doi: 10.1002/ejhf.1847) (Early Online Publication)

Jones, R. et al. (2020) A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer patients not suitable to receive cisplatin. BJU International, (doi: 10.1111/bju.15096) (PMID:32336008) (Early Online Publication)

Baillie, K. et al. (2020) Use of record linkage to evaluate treatment outcomes and trial eligibility in a real‐world metastatic prostate cancer population in Scotland. Pharmacoepidemiology and Drug Safety, (doi: 10.1002/pds.4998) (PMID:32316077) (Early Online Publication)

Birtle, A. et al. (2020) Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial. Lancet, 395(10232), pp. 1268-1277. (doi: 10.1016/S0140-6736(20)30415-3) (PMID:32145825)

Witjes, J. A. et al. (2020) EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multistakeholder effort† EU*ACME: under the auspices of the EAU-ESMO guidelines committees. European Urology, 77(2), pp. 223-250. (doi: 10.1016/j.eururo.2019.09.035) (PMID:31753752)

Mateo, J. et al. (2020) Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncology, 21(1), pp. 162-174. (doi: 10.1016/S1470-2045(19)30684-9) (PMID:31806540) (PMCID:PMC6941219)

2019

Clark, E. et al. (2019) Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol. BMJ Open, 9(12), e034708. (doi: 10.1136/bmjopen-2019-034708) (PMID:31857319) (PMCID:PMC6937062)

Paterson, C. et al. (2019) Radiotherapy-induced xerostomia: a randomised, double-blind, controlled trial of Visco-ease™ oral spray compared with placebo in patients with cancer of the head and neck. British Journal of Oral and Maxillofacial Surgery, 57(10), pp. 1119-1125. (doi: 10.1016/j.bjoms.2019.10.300) (PMID:31672256)

Clarke, N. W. et al. (2019) Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial. Annals of Oncology, 30(123), pp. 1992-2003. (doi: 10.1093/annonc/mdz396) (PMID:31560068) (PMCID:PMC6938598)

Hoyle, A. P. et al. (2019) Abiraterone in "high-" and "low-risk" metastatic hormone-sensitive prostate cancer. European Urology, 76(6), pp. 719-728. (doi: 10.1016/j.eururo.2019.08.006) (PMID:31447077)

Horwich, A. et al. (2019) EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees. Annals of Oncology, 30(11), pp. 1697-1727. (doi: 10.1093/annonc/mdz296) (PMID:31740927)

Hasan, M. N., Rouprêt, M., Keeley, F., Cracco, C., Jones, R. , Straub, M., Traxer, O., Osther, P. J. S. and Brehmer, M. (2019) Consultation on UTUC, Stockholm 2018 aspects of risk stratification: long-term results and follow-up. World Journal of Urology, 37(11), pp. 2289-2296. (doi: 10.1007/s00345-019-02739-1) (PMID:30944969) (PMCID:PMC6825637)

Jung, H., Giusti, G., Fajkovic, H., Herrmann, T., Jones, R. , Straub, M., Baard, J., Osther, P. J. S. and Brehmer, M. (2019) Consultation on UTUC, Stockholm 2018: aspects of treatment. World Journal of Urology, 37(11), pp. 2279-2287. (doi: 10.1007/s00345-019-02811-w) (PMID:31123852) (PMCID:PMC6825640)

Attard, G. et al. (2019) Assessment of the safety of glucocorticoid regimens in combination with abiraterone acetate formetastatic castration-resistant prostate Cancer: a randomized, open-label phase 2 study. JAMA Oncology, 5(8), pp. 1159-1167. (doi: 10.1001/jamaoncol.2019.1011) (PMID:31246234) (PMCID:PMC6604092)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Anderson, R. L. et al. (2019) A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology, 16(3), pp. 185-204. (doi: 10.1038/s41571-018-0134-8) (PMID:30514977)

Hall, P. E. et al. (2019) Radiological response heterogeneity is of prognostic significance in metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. European Urology Focus, (doi: 10.1016/j.euf.2019.01.010) (PMID:30738795) (Early Online Publication)

2018

Dobbin, S. J.H. , Cameron, A. C., Petrie, M. C. , Jones, R. J. , Touyz, R. M. and Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104(24), pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726) (PMID:30228246) (PMCID:PMC6268130)

Hussain, S. A., Birtle, A., Crabb, S., Huddart, R., Small, D., Summerhayes, M., Jones, R. and Protheroe, A. (2018) From clinical trials to real-life clinical practice: the role of immunotherapy with PD-1/PD-L1 inhibitors in advanced urothelial carcinoma. European Urology Oncology, 1(6), pp. 486-500. (doi: 10.1016/j.euo.2018.05.011) (PMID:31158093)

Parker, C. C. et al. (2018) Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet, 392(10162), pp. 2353-2366. (doi: 10.1016/S0140-6736(18)32486-3) (PMID:30355464) (PMCID:PMC6269599)

Woods, B. S. et al. (2018) Addition of docetaxel to first-line long-term hormone therapy in prostate cancer (STAMPEDE): modelling to estimate long-term survival, quality-adjusted survival, and cost-effectiveness. European Urology Oncology, 1(6), pp. 449-458. (doi: 10.1016/j.euo.2018.06.004) (PMID:31158087) (PMCID:PMC6692495)

Sydes, M. R. et al. (2018) Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol. Annals of Oncology, 29(5), pp. 1235-1248. (doi: 10.1093/annonc/mdy072) (PMID:29529169)

Schmidinger, M., Danesi, R., Jones, R. , McDermott, R., Pyle, L., Rini, B. and Négrier, S. (2018) Individualized dosing with axitinib: rationale and practical guidance. Future Oncology, 14(9), pp. 861-875. (doi: 10.2217/fon-2017-0455) (PMID:29264944)

Rulach, R. J. et al. (2018) Real world uptake, safety profile and outcomes of docetaxel in newly diagnosed metastatic prostate cancer. BJU International, 121(2), pp. 268-274. (doi: 10.1111/bju.14025) (PMID:28940952)

Bilsland, A. , Kelly, C., Roccisana, J., Paul, J. , Jones, R. , Edwards, J. , Roseweir, A. , Stein, T. and West, K. (2018) An Exploratory Study on the Use of Game-based Learning Using Microsoft Kinect to Teach Oncology Phase I Clinical Trial Designs. 2018 NCRI Cancer Conference, Glasgow, UK, 04-06 Nov 2018. (doi:10.1038/s41416-018-0299-z)

Jones, R. J. (2018) Neoadjuvant vs. adjuvant chemotherapy: which is right? In: Soria, F. and Gontero, P. (eds.) Treating Urothelial Bladder Cancer. Springer: Cham, pp. 75-81. ISBN 9783319785585 (doi:10.1007/978-3-319-78559-2_10)

Jones, R. J. (2018) The role of medical oncologist. In: Soria, F. and Gontero, P. (eds.) Treating Urothelial Bladder Cancer. Springer: Cham, pp. 119-122. ISBN 9783319785585 (doi:10.1007/978-3-319-78559-2_15)

2017

Ross, K. and Jones, R. J. (2017) Immune checkpoint inhibitors in renal cell carcinoma. Clinical Science, 131(21), pp. 2627-2642. (doi: 10.1042/CS20160894) (PMID:29079639)

MacLennan, S. et al. (2017) A core outcome set for localised prostate cancer effectiveness trials. BJU International, 120(5B), E64-E79. (doi: 10.1111/bju.13854) (PMID:28346770)

Crabb, S. J. et al. (2017) ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer. Investigational New Drugs, 35(5), pp. 599-607. (doi: 10.1007/s10637-017-0433-4) (PMID:28144789) (PMCID:PMC5613074)

Escudier, B. et al. (2017) A phase II multicentre, open-label, proof-of-concept study of tasquinimod in hepatocellular, ovarian, renal cell, and gastric cancers. Targeted Oncology, 12(5), pp. 655-661. (doi: 10.1007/s11523-017-0525-2) (PMID:28798986)

James, N. D. et al. (2017) Abiraterone for prostate cancer not previously treated with hormone therapy. New England Journal of Medicine, 377(4), pp. 338-351. (doi: 10.1056/NEJMoa1702900) (PMID:28578639)

Jones, R. J. et al. (2017) Randomized phase II study investigating pazopanib versus weekly paclitaxel in relapsed or progressive urothelial cancer. Journal of Clinical Oncology, 35(16), pp. 1770-1777. (doi: 10.1200/JCO.2016.70.7828) (PMID:28402747)

Gore, M. E., Jones, R. J. , Ravaud, A., Kuczyk, M., Demkow, T., Bearz, A., Shapiro, J., Strauss, U. P. and Porta, C. (2017) Sorafenib dose escalation in treatment-naïve patients with metastatic renal cell carcinoma: a non-randomised, open-label, Phase 2b study. BJU International, 119(6), pp. 846-853. (doi: 10.1111/bju.13740) (PMID:27981711)

Mason, M. D. et al. (2017) Adding celecoxib with or without zoledronic acid for hormone-naïve prostate cancer: long-term survival results from an adaptive, multiarm, multistage, platform, randomized controlled trial. Journal of Clinical Oncology, 35(14), pp. 1530-1541. (doi: 10.1200/JCO.2016.69.0677) (PMID:28300506)

Jones, R. J. and Brown, J. (2017) Circulating biomarkers in cancer care: what possible use? Practical Laboratory Medicine, 7, pp. 45-48. (doi: 10.1016/j.plabm.2016.04.004) (PMID:28856218) (PMCID:PMC5575409)

Powles, T. et al. (2017) Phase III, double-blind, randomized trial that compared maintenance lapatinib versus placebo after first-line chemotherapy in patients with human epidermal growth factor receptor 1/2-positive metastatic bladder cancer. Journal of Clinical Oncology, 35(1), pp. 48-55. (doi: 10.1200/JCO.2015.66.3468) (PMID:28034079)

2016

Reza, M. et al. (2016) Bone scan index and progression-free survival data for progressive metastatic castration-resistant prostate cancer patients who received ODM-201 in the ARADES multicentre study. European Urology Focus, 2(5), pp. 547-552. (doi: 10.1016/j.euf.2016.01.005) (PMID:28723521)

Powles, T. et al. (2016) Safety and efficacy of pazopanib therapy prior to planned nephrectomy in metastatic clear cell renal cancer. JAMA Oncology, 2(10), pp. 1303-1309. (doi: 10.1001/jamaoncol.2016.1197) (PMID:27254750)

Conteduca, V. et al. (2016) Association between early PSA increase and clinical outcome in patients treated with enzalutamide for metastatic castration resistant prostate cancer. Molecular Diagnosis and Therapy, 20(3), pp. 255-263. (doi: 10.1007/s40291-016-0196-1) (PMID:27020582)

Davda, R., Hughes, S., Jones, R. , Crabb, S.J., Troup, J. and Payne, H. (2016) Chemotherapy at first diagnosis of advanced prostate cancer – revolution or evolution? Findings from a British uro-oncology group UK survey to evaluate oncologists' views on first-line docetaxel in combination with androgen deprivation therapy in castrate-sensitive metastatic and high-risk/locally advanced prostate cancer. Clinical Oncology, 28(6), pp. 376-385. (doi: 10.1016/j.clon.2016.01.006) (PMID:26874654)

Armstrong, A. J. et al. (2016) Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial. Lancet Oncology, 17(3), pp. 378-388. (doi: 10.1016/S1470-2045(15)00515-X) (PMID:26794930)

Wagstaff, J., Jones, R. , Hawkins, R., Porfiri, E., Pickering, L., Bahl, A., Brown, J. and Buchan, S. (2016) Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry. Annals of Oncology, 27(1), pp. 159-165. (doi: 10.1093/annonc/mdv504) (PMID:26489444) (PMCID:PMC4684158)

Conteduca, V. et al. (2016) Persistent neutrophil to lymphocyte ratio >3 during treatment with enzalutamide and clinical outcome in patients with castration-resistant prostate cancer. PLoS ONE, 11(7), e0158952. (doi: 10.1371/journal.pone.0158952) (PMID:27434372) (PMCID:PMC4951050)

Fulton, B. and Jones, R. J. (2016) Combination treatment strategies with docetaxel in patients with metastatic prostate. In: Balaji, K.C. (ed.) Managing Metastatic Prostate Cancer In Your Urological Oncology Practice. Springer: Cham, pp. 93-105. ISBN 9783319313399 (doi:10.1007/978-3-319-31341-2_7)

James, N. D. et al. (2016) Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform-randomised controlled trial. Lancet, 387(10024), pp. 1163-1177. (doi: 10.1016/S0140-6736(15)01037-5) (PMID:26719232)

Powles, T. et al. (2016) A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK). Annals of Oncology, 27(5), pp. 880-886. (doi: 10.1093/annonc/mdw014) (PMID:26802156)

Roseweir, A. K. , Qayyum, T., Lim, Z., Hammond, R., MacDonald, A. I., Fraser, S., Oades, G. M., Aitchison, M., Jones, R. J. and Edwards, J. (2016) Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients. BMC Cancer, 16, p. 229. (doi: 10.1186/s12885-016-2254-9) (PMID:26984511) (PMCID:PMC4794832)

2015

Bahl, A. et al. (2015) Final quality of life and safety data for patients with metastatic castration-resistant prostate cancer treated with cabazitaxel in the UK Early Access Programme (EAP) (NCT01254279). BJU International, 116(6), pp. 880-887. (doi: 10.1111/bju.13069) (PMID:25639506)

Hanna, C. and Jones, R. J. (2015) Emerging treatments for recurrent prostate cancer. Future Oncology, 11(21), pp. 2873-2880. (doi: 10.2217/fon.15.228) (PMID:26436556)

Eisen, T., Loembé, A.-B., Shparyk, Y., MacLeod, N., Jones, R.J. , Mazurkiewicz, M., Temple, G., Dressler, H. and Bondarenko, I. (2015) A randomised, phase II study of nintedanib or sunitinib in previously untreated patients with advanced renal cell cancer: 3-year results. British Journal of Cancer, 113(8), pp. 1140-1147. (doi: 10.1038/bjc.2015.313) (PMID:26448178) (PMCID:PMC4647871)

Boyd, K. A. , Jones, R. J. , Paul, J. , Birrell, F., Briggs, A. H. and Leung, H. Y. (2015) Decision-analytic cost-effectiveness model to compare prostate cryotherapy to androgen deprivation therapy for treatment of radiation recurrent prostate cancer. BMJ Open, 5(10), e007925. (doi: 10.1136/bmjopen-2015-007925) (PMID:26482768) (PMCID:PMC4611206)

Mateo, J. et al. (2015) DNA-repair defects and olaparib in metastatic prostate cancer. New England Journal of Medicine, 373(18), pp. 1697-1708. (doi: 10.1056/NEJMoa1506859) (PMID:26510020)

Huddart, R.A., Jones, R. and Choudhury, A. (2015) A new dawn for bladder cancer? Recommendations from the national institute for health and care excellence (NICE) on managing bladder cancer. Clinical Oncology, 27(7), pp. 380-381. (doi: 10.1016/j.clon.2015.03.008) (PMID:25869257)

James, N. D. et al. (2015) Survival with newly diagnosed metastatic prostate cancer in the "Docetaxel Era": data from 917 patients in the control arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019). European Urology, 67(6), pp. 1028-1038. (doi: 10.1016/j.eururo.2014.09.032) (PMID:25301760)

Omlin, A. et al. (2015) AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies. Investigational New Drugs, 33(3), pp. 679-690. (doi: 10.1007/s10637-015-0235-5) (PMID:25920479)

Geldart, T. et al. (2015) SUCCINCT: an open-label, single-arm, non-randomised, Phase 2 Trial of gemcitabine and cisplatin chemotherapy in combination with sunitinib as first-line treatment for patients with advanced urothelial carcinoma. European Urology, 67(4), pp. 599-602. (doi: 10.1016/j.eururo.2014.11.003)

Fizazi, K. et al. (2015) Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy: ELM-PC 5. Journal of Clinical Oncology, 33(7), pp. 723-731. (doi: 10.1200/JCO.2014.56.5119) (PMID:25624429)

Saad, F. et al. (2015) Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial. Lancet Oncology, 16(3), pp. 338-348. (doi: 10.1016/S1470-2045(15)70027-6) (PMID:25701170)

Jones, R. J. (2015) Making trials work in practice: please mind the gap. European Urology, 67(2), pp. 250-251. (doi: 10.1016/j.eururo.2014.10.006)

Harris, R., Oake, K., Hawkins, R. E., Jones, R. J. , Powles, T. and Montgomery, D. A. (2015) Patient needs in advanced renal cell carcinoma: what are patients’ priorities and how well are we meeting them. Patient Experience Journal, 2(2), 18.

Payne, H., Davda, R., Jones, R. , Crabb, S., Troup, J. and Hughes, S. (2015) Advances in advanced prostate cancer - the continuing journey. BJU International, 118(1), pp. 17-19. (doi: 10.1111/bju.13350) (PMID:26456636)

2014

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (doi: 10.1371/journal.pbio.1001966) (PMID:25313567) (PMCID:PMC4196730)

Loriot, Y. et al. (2014) Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Investigational New Drugs, 32(5), pp. 995-1004. (doi: 10.1007/s10637-014-0101-x)

Jones, R. J. (2014) Sequencing systemic therapies in advanced prostate cancer: spoiled for choice but not for evidence. European Urology, 66(3), pp. 466-467. (doi: 10.1016/j.eururo.2013.12.053)

Powles, T. et al. (2014) A phase Ib study investigating the combination of everolimus and dovitinib in vascular endothelial growth factor refractory clear cell renal cancer. European Journal of Cancer, 50(12), pp. 2057-64. (doi: 10.1016/j.ejca.2014.04.021)

Boyd, K.A. , Jones, R.J. , Paul, J. , Briggs, A. and Leung, H.Y. (2014) A decision-analytic cost-effectiveness model to compare treatment options for radiation recurrent prostate cancer against androgen deprivation therapy. British Journal of Surgery, 101(s4), p. 59. (doi: 10.1002/bjs.9510)

Molife, L. .R. et al. (2014) Randomized Phase II trial of nintedanib, afatinib and sequential combination in castration-resistant prostate cancer. Future Oncology, 10(2), pp. 219-231. (doi: 10.2217/fon.13.250)

Michaelson, M. D. et al. (2014) Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer. Journal of Clinical Oncology, 32(2), pp. 76-82. (doi: 10.1200/JCO.2012.48.5268)

Salji, M., Jones, R. , Paul, J. , Birrell, F., Dixon-Hughes, J., Hutchison, C., Johansen, T.E.B., Greene, D., Parr, N. and Leung, H.Y. (2014) Feasibility study of a randomised controlled trial to compare (deferred) androgen deprivation therapy and cryotherapy in men with localised radiation-recurrent prostate cancer. British Journal of Cancer, 111(3), pp. 424-429. (doi: 10.1038/bjc.2014.316)

2013

Eisen, T. et al. (2013) Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II study. Investigational New Drugs, 31(5), pp. 1283-1293. (doi: 10.1007/s10637-013-9962-7)

Jones, R. and DeSantis, M. (2013) Access to targeted therapies in renal cell cancer. Seminars in Oncology, 40(4), pp. 521-528. (doi: 10.1053/j.seminoncol.2013.05.012)

Ford, J. et al. (2013) Systematic review of the clinical effectiveness and cost-effectiveness, and economic evaluation, of denosumab for the treatment of bone metastases from solid tumours. Health Technology Assessment, 17(29), pp. 1-386. (doi: 10.3310/hta17290)

Jones, R. (2013) Urological medical oncology: land of opportunity. Future Oncology, 9(2), pp. 149-152. (doi: 10.2217/FON.12.176)

Ford, J.A., Jones, R. , Elders, A., Mulatero, C., Royle, P., Sharma, P., Stewart, F., Todd, R. and Mowatt, G. (2013) Denosumab for treatment of bone metastases secondary to solid tumours: systematic review and network meta-analysis. European Journal of Cancer, 49(2), pp. 416-430. (doi: 10.1016/j.ejca.2012.07.016)

Jones, R. et al. (2013) Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer. Investigational New Drugs, 31(4), pp. 1001-1007. (doi: 10.1007/s10637-013-9926-y)

Motzer, R.J. et al. (2013) Pazopanib versus Sunitinib in metastatic renal-cell carcinoma. New England Journal of Medicine, 369(8), pp. 722-731. (doi: 10.1056/NEJMoa1303989)

Salazar, R. et al. (2013) A phase I and pharmacokinetic study of elisidepsin (PM02734) in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology, 70(5), pp. 673-681. (doi: 10.1007/s00280-012-1951-6)

Venugopal, B., Ansari, J., Aitchison, M., Tho, L., Campbell, R. and Jones, R.J. (2013) Efficacy of temsirolimus in metastatic chromophobe renal cell carcinoma. BMC Urology, 13(26), (doi: 10.1186/1471-2490-13-26)

2012

Logothetis, C.J. et al. (2012) Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial. Lancet Oncology, 13(12), pp. 1210-1217. (doi: 10.1016/S1470-2045(12)70473-4)

Olmos, D. et al. (2012) Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study. Lancet Oncology, 13(11), pp. 1114-1124. (doi: 10.1016/S1470-2045(12)70372-8)

Powles, T. et al. (2012) An indirect comparison of the toxicity of sunitinib and pazopanib in metastatic clear cell renal cancer. European Journal of Cancer, 48(17), pp. 3171-3176. (doi: 10.1016/j.ejca.2012.05.022)

Fizazi, K. et al. (2012) Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncology, 13(10), pp. 983-992. (doi: 10.1016/S1470-2045(12)70379-0)

Ford, J.A., Mowatt, G. and Jones, R.J. (2012) Assessing pharmacological interventions for bone metastases: the need for more patient-centered outcomes. Expert Review of Clinical Pharmacology, 5(3), pp. 271-279. (doi: 10.1586/ecp.12.21)

Kaye, S. et al. (2012) Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours. British Journal of Cancer, 106(11), pp. 1728-1734. (doi: 10.1038/bjc.2012.158)

Leach, M.O. et al. (2012) Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging. European Radiology, 22(7), pp. 1451-1464. (doi: 10.1007/s00330-012-2446-x)

Qayyum, T. et al. (2012) Abstracts of the 10th International Kidney Cancer Symposium: The role of Src kinase in renal cell cancer. BJU International, 109(S5), p. 10. (doi: 10.1111/j.1464-410X.2012.11171.x)

Qayyum, T. et al. (2012) Expression and prognostic significance of Src family members in renal clear cell carcinoma. British Journal of Cancer, 107(5), pp. 856-863. (doi: 10.1038/bjc.2012.314)

2011

Harrington, J.A. and Jones, R.J. (2011) Management of metastatic castration-resistant prostate cancer after first-line docetaxel. European Journal of Cancer, 47(14), pp. 2133-2142. (doi: 10.1016/j.ejca.2011.04.036)

de Bono, J.S. et al. (2011) Abiraterone and increased survival in metastatic prostate cancer. New England Journal of Medicine, 364(21), pp. 1995-2005. (doi: 10.1056/NEJMoa1014618)

Le Pechoux, C. et al. (2011) Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01). Annals of Oncology, 22(5), pp. 1154-1163. (doi: 10.1093/annonc/mdq576)

Powles, T., Chowdhury, S., Jones, R. , Mantle, M., Nathan, P., Bex, A., Lim, L. and Hutson, T. (2011) Sunitinib and other targeted therapies for renal cell carcinoma. British Journal of Cancer, 104(5), pp. 741-745. (doi: 10.1038/sj.bjc.6606061)

Jones, R.J. , Green, T.P. and Elvin, P. (2011) Discovery and development of drugs targeting tumour invasion and metastasis. In: Lyden, D., Welch, D.R. and Psaila, B. (eds.) Cancer Metastasis: Biologic Basis and Therapeutics. Cambridge University Press, pp. 600-611. ISBN 9780521887212

2010

Powles, T., Jones, R.J. , Chowdhury, S., Shamash, J., Mantle, M., Lim, L. and Hutson, T. (2010) The application of the National Institute of Clinical Excellence guidelines for treatment of metastatic renal cell carcinoma in the United Kingdom: friend or foe? BJU International, 106(4), pp. 453-457. (doi: 10.1111/j.1464-410X.2010.09466.x)

2009

Paterson, C. and Jones, R.J. (2009) Tumour Flare during Interruption of Temsirolimus Treatment for Metastatic Renal Cell Cancer. Clinical Oncology, 21(9), pp. 732-733. (doi: 10.1016/j.clon.2009.07.006)

Jones, R. J. et al. (2009) Src inhibitors in early breast cancer: a methodology, feasibility and variability study. Breast Cancer Research and Treatment, 114(2), pp. 211-221. (doi: 10.1007/s10549-008-9997-1)

2008

Jones, R., Hawkins, R., Eatock, M., Ferry, D., Eskens, F., Wilke, H. and Evans, T. (2008) A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma. Cancer Chemotherapy and Pharmacology, 61(3), pp. 435-441. (doi: 10.1007/s00280-007-0486-8)

Twelves, C., Trigo, J. M., Jones, R. , De Rosa, F., Rakhit, A., Fettner, S., Wright, T. and Baselga, J. (2008) Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: a dose-escalation study. European Journal of Cancer, 44(3), pp. 419-426. (doi: 10.1016/j.ejca.2007.12.011)

Jones, R.J. , Boyce, T., Fennell, M., Jacobs, V., Pinto, F., Duffield, E., Clack, G., Green, T., Kelly, J. and Robertson, J. (2008) The impact of delay in cryo-fixation on biomarkers of Src tyrosine kinase activity in human breast and bladder cancers. Cancer Chemotherapy and Pharmacology, 61(1), pp. 23-32. (doi: 10.1007/s00280-007-0440-9)

2007

Hanauske, A., Cassidy, J., Sastre, J., Bolling, C., Jones, R. , Rakhit, A., Fettner, S., Brennscheidt, U., Feyereislova, A. and Diaz-Rubio, E. (2007) Phase 1b dose escalation study of erlotinib in combination with infusional 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced solid tumors. Clinical Cancer Research, 13(2), pp. 523-531. (doi: 10.1158/1078-0432.CCR-06-1627)

MacPherson, I. , Jones, R. and Evans, T. (2007) Clinical development of src family kinase inhibitors in malignant melanoma. Open Cancer Journal, 2007(1), pp. 9-20. (doi: 10.2174/1874079000701010009)

2003

Glen, H. and Jones, R.J. (2003) 8th international conference: primary therapy of early breast cancer, St Gallen, Switzerland, March 12-15 2003. Breast Cancer Research, 5(4), pp. 198-201. (doi: 10.1186/bcr611)

2002

Jones, R. , Avizienyte, E., Wyke, A., Owens, D., Brunton, V. and Frame, M. (2002) Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM1 2C human colorectal cancer cells. British Journal of Cancer, 87(10), pp. 1128-1135. (doi: 10.1038/sj.bjc.6600594)

Avizienyte, E., Wyke, A., Jones, R. , McLean, G., Westhoff, M., Brunton, V. and Frame, M. (2002) Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nature Cell Biology, 4(8), pp. 632-638. (doi: 10.1038/ncb829)

Jones, R. and Twelves, C. (2002) Pemetrexed: a multitargeted antifolate (ALIMTA, LY-231514). Expert Review of Anticancer Therapy, 2(1), pp. 13-22. (doi: 10.1586/14737140.2.1.13)

2001

Twelves, C. and Jones, R. (2001) Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil? Expert Opinion on Pharmacotherapy, 2(9), pp. 1495-1505. (doi: 10.1517/14656566.2.9.1495)

This list was generated on Thu Jun 4 19:38:36 2020 BST.
Number of items: 107.

Articles

Pritchard, J. J.G., Hamilton, G., Hurst, C. D., Fraser, S., Orange, C., Knowles, M. A., Jones, R. J. , Leung, H. Y. and Iwata, T. (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, (Accepted for Publication)

Dobbin, S. J.H. et al. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, (doi: 10.1002/ejhf.1847) (Early Online Publication)

Jones, R. et al. (2020) A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer patients not suitable to receive cisplatin. BJU International, (doi: 10.1111/bju.15096) (PMID:32336008) (Early Online Publication)

Baillie, K. et al. (2020) Use of record linkage to evaluate treatment outcomes and trial eligibility in a real‐world metastatic prostate cancer population in Scotland. Pharmacoepidemiology and Drug Safety, (doi: 10.1002/pds.4998) (PMID:32316077) (Early Online Publication)

Birtle, A. et al. (2020) Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial. Lancet, 395(10232), pp. 1268-1277. (doi: 10.1016/S0140-6736(20)30415-3) (PMID:32145825)

Witjes, J. A. et al. (2020) EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multistakeholder effort† EU*ACME: under the auspices of the EAU-ESMO guidelines committees. European Urology, 77(2), pp. 223-250. (doi: 10.1016/j.eururo.2019.09.035) (PMID:31753752)

Mateo, J. et al. (2020) Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncology, 21(1), pp. 162-174. (doi: 10.1016/S1470-2045(19)30684-9) (PMID:31806540) (PMCID:PMC6941219)

Clark, E. et al. (2019) Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol. BMJ Open, 9(12), e034708. (doi: 10.1136/bmjopen-2019-034708) (PMID:31857319) (PMCID:PMC6937062)

Paterson, C. et al. (2019) Radiotherapy-induced xerostomia: a randomised, double-blind, controlled trial of Visco-ease™ oral spray compared with placebo in patients with cancer of the head and neck. British Journal of Oral and Maxillofacial Surgery, 57(10), pp. 1119-1125. (doi: 10.1016/j.bjoms.2019.10.300) (PMID:31672256)

Clarke, N. W. et al. (2019) Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial. Annals of Oncology, 30(123), pp. 1992-2003. (doi: 10.1093/annonc/mdz396) (PMID:31560068) (PMCID:PMC6938598)

Hoyle, A. P. et al. (2019) Abiraterone in "high-" and "low-risk" metastatic hormone-sensitive prostate cancer. European Urology, 76(6), pp. 719-728. (doi: 10.1016/j.eururo.2019.08.006) (PMID:31447077)

Horwich, A. et al. (2019) EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees. Annals of Oncology, 30(11), pp. 1697-1727. (doi: 10.1093/annonc/mdz296) (PMID:31740927)

Hasan, M. N., Rouprêt, M., Keeley, F., Cracco, C., Jones, R. , Straub, M., Traxer, O., Osther, P. J. S. and Brehmer, M. (2019) Consultation on UTUC, Stockholm 2018 aspects of risk stratification: long-term results and follow-up. World Journal of Urology, 37(11), pp. 2289-2296. (doi: 10.1007/s00345-019-02739-1) (PMID:30944969) (PMCID:PMC6825637)

Jung, H., Giusti, G., Fajkovic, H., Herrmann, T., Jones, R. , Straub, M., Baard, J., Osther, P. J. S. and Brehmer, M. (2019) Consultation on UTUC, Stockholm 2018: aspects of treatment. World Journal of Urology, 37(11), pp. 2279-2287. (doi: 10.1007/s00345-019-02811-w) (PMID:31123852) (PMCID:PMC6825640)

Attard, G. et al. (2019) Assessment of the safety of glucocorticoid regimens in combination with abiraterone acetate formetastatic castration-resistant prostate Cancer: a randomized, open-label phase 2 study. JAMA Oncology, 5(8), pp. 1159-1167. (doi: 10.1001/jamaoncol.2019.1011) (PMID:31246234) (PMCID:PMC6604092)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Anderson, R. L. et al. (2019) A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology, 16(3), pp. 185-204. (doi: 10.1038/s41571-018-0134-8) (PMID:30514977)

Hall, P. E. et al. (2019) Radiological response heterogeneity is of prognostic significance in metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. European Urology Focus, (doi: 10.1016/j.euf.2019.01.010) (PMID:30738795) (Early Online Publication)

Dobbin, S. J.H. , Cameron, A. C., Petrie, M. C. , Jones, R. J. , Touyz, R. M. and Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104(24), pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726) (PMID:30228246) (PMCID:PMC6268130)

Hussain, S. A., Birtle, A., Crabb, S., Huddart, R., Small, D., Summerhayes, M., Jones, R. and Protheroe, A. (2018) From clinical trials to real-life clinical practice: the role of immunotherapy with PD-1/PD-L1 inhibitors in advanced urothelial carcinoma. European Urology Oncology, 1(6), pp. 486-500. (doi: 10.1016/j.euo.2018.05.011) (PMID:31158093)

Parker, C. C. et al. (2018) Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet, 392(10162), pp. 2353-2366. (doi: 10.1016/S0140-6736(18)32486-3) (PMID:30355464) (PMCID:PMC6269599)

Woods, B. S. et al. (2018) Addition of docetaxel to first-line long-term hormone therapy in prostate cancer (STAMPEDE): modelling to estimate long-term survival, quality-adjusted survival, and cost-effectiveness. European Urology Oncology, 1(6), pp. 449-458. (doi: 10.1016/j.euo.2018.06.004) (PMID:31158087) (PMCID:PMC6692495)

Sydes, M. R. et al. (2018) Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol. Annals of Oncology, 29(5), pp. 1235-1248. (doi: 10.1093/annonc/mdy072) (PMID:29529169)

Schmidinger, M., Danesi, R., Jones, R. , McDermott, R., Pyle, L., Rini, B. and Négrier, S. (2018) Individualized dosing with axitinib: rationale and practical guidance. Future Oncology, 14(9), pp. 861-875. (doi: 10.2217/fon-2017-0455) (PMID:29264944)

Rulach, R. J. et al. (2018) Real world uptake, safety profile and outcomes of docetaxel in newly diagnosed metastatic prostate cancer. BJU International, 121(2), pp. 268-274. (doi: 10.1111/bju.14025) (PMID:28940952)

Ross, K. and Jones, R. J. (2017) Immune checkpoint inhibitors in renal cell carcinoma. Clinical Science, 131(21), pp. 2627-2642. (doi: 10.1042/CS20160894) (PMID:29079639)

MacLennan, S. et al. (2017) A core outcome set for localised prostate cancer effectiveness trials. BJU International, 120(5B), E64-E79. (doi: 10.1111/bju.13854) (PMID:28346770)

Crabb, S. J. et al. (2017) ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer. Investigational New Drugs, 35(5), pp. 599-607. (doi: 10.1007/s10637-017-0433-4) (PMID:28144789) (PMCID:PMC5613074)

Escudier, B. et al. (2017) A phase II multicentre, open-label, proof-of-concept study of tasquinimod in hepatocellular, ovarian, renal cell, and gastric cancers. Targeted Oncology, 12(5), pp. 655-661. (doi: 10.1007/s11523-017-0525-2) (PMID:28798986)

James, N. D. et al. (2017) Abiraterone for prostate cancer not previously treated with hormone therapy. New England Journal of Medicine, 377(4), pp. 338-351. (doi: 10.1056/NEJMoa1702900) (PMID:28578639)

Jones, R. J. et al. (2017) Randomized phase II study investigating pazopanib versus weekly paclitaxel in relapsed or progressive urothelial cancer. Journal of Clinical Oncology, 35(16), pp. 1770-1777. (doi: 10.1200/JCO.2016.70.7828) (PMID:28402747)

Gore, M. E., Jones, R. J. , Ravaud, A., Kuczyk, M., Demkow, T., Bearz, A., Shapiro, J., Strauss, U. P. and Porta, C. (2017) Sorafenib dose escalation in treatment-naïve patients with metastatic renal cell carcinoma: a non-randomised, open-label, Phase 2b study. BJU International, 119(6), pp. 846-853. (doi: 10.1111/bju.13740) (PMID:27981711)

Mason, M. D. et al. (2017) Adding celecoxib with or without zoledronic acid for hormone-naïve prostate cancer: long-term survival results from an adaptive, multiarm, multistage, platform, randomized controlled trial. Journal of Clinical Oncology, 35(14), pp. 1530-1541. (doi: 10.1200/JCO.2016.69.0677) (PMID:28300506)

Jones, R. J. and Brown, J. (2017) Circulating biomarkers in cancer care: what possible use? Practical Laboratory Medicine, 7, pp. 45-48. (doi: 10.1016/j.plabm.2016.04.004) (PMID:28856218) (PMCID:PMC5575409)

Powles, T. et al. (2017) Phase III, double-blind, randomized trial that compared maintenance lapatinib versus placebo after first-line chemotherapy in patients with human epidermal growth factor receptor 1/2-positive metastatic bladder cancer. Journal of Clinical Oncology, 35(1), pp. 48-55. (doi: 10.1200/JCO.2015.66.3468) (PMID:28034079)

Reza, M. et al. (2016) Bone scan index and progression-free survival data for progressive metastatic castration-resistant prostate cancer patients who received ODM-201 in the ARADES multicentre study. European Urology Focus, 2(5), pp. 547-552. (doi: 10.1016/j.euf.2016.01.005) (PMID:28723521)

Powles, T. et al. (2016) Safety and efficacy of pazopanib therapy prior to planned nephrectomy in metastatic clear cell renal cancer. JAMA Oncology, 2(10), pp. 1303-1309. (doi: 10.1001/jamaoncol.2016.1197) (PMID:27254750)

Conteduca, V. et al. (2016) Association between early PSA increase and clinical outcome in patients treated with enzalutamide for metastatic castration resistant prostate cancer. Molecular Diagnosis and Therapy, 20(3), pp. 255-263. (doi: 10.1007/s40291-016-0196-1) (PMID:27020582)

Davda, R., Hughes, S., Jones, R. , Crabb, S.J., Troup, J. and Payne, H. (2016) Chemotherapy at first diagnosis of advanced prostate cancer – revolution or evolution? Findings from a British uro-oncology group UK survey to evaluate oncologists' views on first-line docetaxel in combination with androgen deprivation therapy in castrate-sensitive metastatic and high-risk/locally advanced prostate cancer. Clinical Oncology, 28(6), pp. 376-385. (doi: 10.1016/j.clon.2016.01.006) (PMID:26874654)

Armstrong, A. J. et al. (2016) Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial. Lancet Oncology, 17(3), pp. 378-388. (doi: 10.1016/S1470-2045(15)00515-X) (PMID:26794930)

Wagstaff, J., Jones, R. , Hawkins, R., Porfiri, E., Pickering, L., Bahl, A., Brown, J. and Buchan, S. (2016) Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry. Annals of Oncology, 27(1), pp. 159-165. (doi: 10.1093/annonc/mdv504) (PMID:26489444) (PMCID:PMC4684158)

Conteduca, V. et al. (2016) Persistent neutrophil to lymphocyte ratio >3 during treatment with enzalutamide and clinical outcome in patients with castration-resistant prostate cancer. PLoS ONE, 11(7), e0158952. (doi: 10.1371/journal.pone.0158952) (PMID:27434372) (PMCID:PMC4951050)

James, N. D. et al. (2016) Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform-randomised controlled trial. Lancet, 387(10024), pp. 1163-1177. (doi: 10.1016/S0140-6736(15)01037-5) (PMID:26719232)

Powles, T. et al. (2016) A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK). Annals of Oncology, 27(5), pp. 880-886. (doi: 10.1093/annonc/mdw014) (PMID:26802156)

Roseweir, A. K. , Qayyum, T., Lim, Z., Hammond, R., MacDonald, A. I., Fraser, S., Oades, G. M., Aitchison, M., Jones, R. J. and Edwards, J. (2016) Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients. BMC Cancer, 16, p. 229. (doi: 10.1186/s12885-016-2254-9) (PMID:26984511) (PMCID:PMC4794832)

Bahl, A. et al. (2015) Final quality of life and safety data for patients with metastatic castration-resistant prostate cancer treated with cabazitaxel in the UK Early Access Programme (EAP) (NCT01254279). BJU International, 116(6), pp. 880-887. (doi: 10.1111/bju.13069) (PMID:25639506)

Hanna, C. and Jones, R. J. (2015) Emerging treatments for recurrent prostate cancer. Future Oncology, 11(21), pp. 2873-2880. (doi: 10.2217/fon.15.228) (PMID:26436556)

Eisen, T., Loembé, A.-B., Shparyk, Y., MacLeod, N., Jones, R.J. , Mazurkiewicz, M., Temple, G., Dressler, H. and Bondarenko, I. (2015) A randomised, phase II study of nintedanib or sunitinib in previously untreated patients with advanced renal cell cancer: 3-year results. British Journal of Cancer, 113(8), pp. 1140-1147. (doi: 10.1038/bjc.2015.313) (PMID:26448178) (PMCID:PMC4647871)

Boyd, K. A. , Jones, R. J. , Paul, J. , Birrell, F., Briggs, A. H. and Leung, H. Y. (2015) Decision-analytic cost-effectiveness model to compare prostate cryotherapy to androgen deprivation therapy for treatment of radiation recurrent prostate cancer. BMJ Open, 5(10), e007925. (doi: 10.1136/bmjopen-2015-007925) (PMID:26482768) (PMCID:PMC4611206)

Mateo, J. et al. (2015) DNA-repair defects and olaparib in metastatic prostate cancer. New England Journal of Medicine, 373(18), pp. 1697-1708. (doi: 10.1056/NEJMoa1506859) (PMID:26510020)

Huddart, R.A., Jones, R. and Choudhury, A. (2015) A new dawn for bladder cancer? Recommendations from the national institute for health and care excellence (NICE) on managing bladder cancer. Clinical Oncology, 27(7), pp. 380-381. (doi: 10.1016/j.clon.2015.03.008) (PMID:25869257)

James, N. D. et al. (2015) Survival with newly diagnosed metastatic prostate cancer in the "Docetaxel Era": data from 917 patients in the control arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019). European Urology, 67(6), pp. 1028-1038. (doi: 10.1016/j.eururo.2014.09.032) (PMID:25301760)

Omlin, A. et al. (2015) AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies. Investigational New Drugs, 33(3), pp. 679-690. (doi: 10.1007/s10637-015-0235-5) (PMID:25920479)

Geldart, T. et al. (2015) SUCCINCT: an open-label, single-arm, non-randomised, Phase 2 Trial of gemcitabine and cisplatin chemotherapy in combination with sunitinib as first-line treatment for patients with advanced urothelial carcinoma. European Urology, 67(4), pp. 599-602. (doi: 10.1016/j.eururo.2014.11.003)

Fizazi, K. et al. (2015) Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy: ELM-PC 5. Journal of Clinical Oncology, 33(7), pp. 723-731. (doi: 10.1200/JCO.2014.56.5119) (PMID:25624429)

Saad, F. et al. (2015) Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial. Lancet Oncology, 16(3), pp. 338-348. (doi: 10.1016/S1470-2045(15)70027-6) (PMID:25701170)

Jones, R. J. (2015) Making trials work in practice: please mind the gap. European Urology, 67(2), pp. 250-251. (doi: 10.1016/j.eururo.2014.10.006)

Harris, R., Oake, K., Hawkins, R. E., Jones, R. J. , Powles, T. and Montgomery, D. A. (2015) Patient needs in advanced renal cell carcinoma: what are patients’ priorities and how well are we meeting them. Patient Experience Journal, 2(2), 18.

Payne, H., Davda, R., Jones, R. , Crabb, S., Troup, J. and Hughes, S. (2015) Advances in advanced prostate cancer - the continuing journey. BJU International, 118(1), pp. 17-19. (doi: 10.1111/bju.13350) (PMID:26456636)

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (doi: 10.1371/journal.pbio.1001966) (PMID:25313567) (PMCID:PMC4196730)

Loriot, Y. et al. (2014) Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Investigational New Drugs, 32(5), pp. 995-1004. (doi: 10.1007/s10637-014-0101-x)

Jones, R. J. (2014) Sequencing systemic therapies in advanced prostate cancer: spoiled for choice but not for evidence. European Urology, 66(3), pp. 466-467. (doi: 10.1016/j.eururo.2013.12.053)

Powles, T. et al. (2014) A phase Ib study investigating the combination of everolimus and dovitinib in vascular endothelial growth factor refractory clear cell renal cancer. European Journal of Cancer, 50(12), pp. 2057-64. (doi: 10.1016/j.ejca.2014.04.021)

Boyd, K.A. , Jones, R.J. , Paul, J. , Briggs, A. and Leung, H.Y. (2014) A decision-analytic cost-effectiveness model to compare treatment options for radiation recurrent prostate cancer against androgen deprivation therapy. British Journal of Surgery, 101(s4), p. 59. (doi: 10.1002/bjs.9510)

Molife, L. .R. et al. (2014) Randomized Phase II trial of nintedanib, afatinib and sequential combination in castration-resistant prostate cancer. Future Oncology, 10(2), pp. 219-231. (doi: 10.2217/fon.13.250)

Michaelson, M. D. et al. (2014) Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer. Journal of Clinical Oncology, 32(2), pp. 76-82. (doi: 10.1200/JCO.2012.48.5268)

Salji, M., Jones, R. , Paul, J. , Birrell, F., Dixon-Hughes, J., Hutchison, C., Johansen, T.E.B., Greene, D., Parr, N. and Leung, H.Y. (2014) Feasibility study of a randomised controlled trial to compare (deferred) androgen deprivation therapy and cryotherapy in men with localised radiation-recurrent prostate cancer. British Journal of Cancer, 111(3), pp. 424-429. (doi: 10.1038/bjc.2014.316)

Eisen, T. et al. (2013) Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II study. Investigational New Drugs, 31(5), pp. 1283-1293. (doi: 10.1007/s10637-013-9962-7)

Jones, R. and DeSantis, M. (2013) Access to targeted therapies in renal cell cancer. Seminars in Oncology, 40(4), pp. 521-528. (doi: 10.1053/j.seminoncol.2013.05.012)

Ford, J. et al. (2013) Systematic review of the clinical effectiveness and cost-effectiveness, and economic evaluation, of denosumab for the treatment of bone metastases from solid tumours. Health Technology Assessment, 17(29), pp. 1-386. (doi: 10.3310/hta17290)

Jones, R. (2013) Urological medical oncology: land of opportunity. Future Oncology, 9(2), pp. 149-152. (doi: 10.2217/FON.12.176)

Ford, J.A., Jones, R. , Elders, A., Mulatero, C., Royle, P., Sharma, P., Stewart, F., Todd, R. and Mowatt, G. (2013) Denosumab for treatment of bone metastases secondary to solid tumours: systematic review and network meta-analysis. European Journal of Cancer, 49(2), pp. 416-430. (doi: 10.1016/j.ejca.2012.07.016)

Jones, R. et al. (2013) Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer. Investigational New Drugs, 31(4), pp. 1001-1007. (doi: 10.1007/s10637-013-9926-y)

Motzer, R.J. et al. (2013) Pazopanib versus Sunitinib in metastatic renal-cell carcinoma. New England Journal of Medicine, 369(8), pp. 722-731. (doi: 10.1056/NEJMoa1303989)

Salazar, R. et al. (2013) A phase I and pharmacokinetic study of elisidepsin (PM02734) in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology, 70(5), pp. 673-681. (doi: 10.1007/s00280-012-1951-6)

Venugopal, B., Ansari, J., Aitchison, M., Tho, L., Campbell, R. and Jones, R.J. (2013) Efficacy of temsirolimus in metastatic chromophobe renal cell carcinoma. BMC Urology, 13(26), (doi: 10.1186/1471-2490-13-26)

Logothetis, C.J. et al. (2012) Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial. Lancet Oncology, 13(12), pp. 1210-1217. (doi: 10.1016/S1470-2045(12)70473-4)

Olmos, D. et al. (2012) Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study. Lancet Oncology, 13(11), pp. 1114-1124. (doi: 10.1016/S1470-2045(12)70372-8)

Powles, T. et al. (2012) An indirect comparison of the toxicity of sunitinib and pazopanib in metastatic clear cell renal cancer. European Journal of Cancer, 48(17), pp. 3171-3176. (doi: 10.1016/j.ejca.2012.05.022)

Fizazi, K. et al. (2012) Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncology, 13(10), pp. 983-992. (doi: 10.1016/S1470-2045(12)70379-0)

Ford, J.A., Mowatt, G. and Jones, R.J. (2012) Assessing pharmacological interventions for bone metastases: the need for more patient-centered outcomes. Expert Review of Clinical Pharmacology, 5(3), pp. 271-279. (doi: 10.1586/ecp.12.21)

Kaye, S. et al. (2012) Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours. British Journal of Cancer, 106(11), pp. 1728-1734. (doi: 10.1038/bjc.2012.158)

Leach, M.O. et al. (2012) Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging. European Radiology, 22(7), pp. 1451-1464. (doi: 10.1007/s00330-012-2446-x)

Qayyum, T. et al. (2012) Abstracts of the 10th International Kidney Cancer Symposium: The role of Src kinase in renal cell cancer. BJU International, 109(S5), p. 10. (doi: 10.1111/j.1464-410X.2012.11171.x)

Qayyum, T. et al. (2012) Expression and prognostic significance of Src family members in renal clear cell carcinoma. British Journal of Cancer, 107(5), pp. 856-863. (doi: 10.1038/bjc.2012.314)

Harrington, J.A. and Jones, R.J. (2011) Management of metastatic castration-resistant prostate cancer after first-line docetaxel. European Journal of Cancer, 47(14), pp. 2133-2142. (doi: 10.1016/j.ejca.2011.04.036)

de Bono, J.S. et al. (2011) Abiraterone and increased survival in metastatic prostate cancer. New England Journal of Medicine, 364(21), pp. 1995-2005. (doi: 10.1056/NEJMoa1014618)

Le Pechoux, C. et al. (2011) Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01). Annals of Oncology, 22(5), pp. 1154-1163. (doi: 10.1093/annonc/mdq576)

Powles, T., Chowdhury, S., Jones, R. , Mantle, M., Nathan, P., Bex, A., Lim, L. and Hutson, T. (2011) Sunitinib and other targeted therapies for renal cell carcinoma. British Journal of Cancer, 104(5), pp. 741-745. (doi: 10.1038/sj.bjc.6606061)

Powles, T., Jones, R.J. , Chowdhury, S., Shamash, J., Mantle, M., Lim, L. and Hutson, T. (2010) The application of the National Institute of Clinical Excellence guidelines for treatment of metastatic renal cell carcinoma in the United Kingdom: friend or foe? BJU International, 106(4), pp. 453-457. (doi: 10.1111/j.1464-410X.2010.09466.x)

Paterson, C. and Jones, R.J. (2009) Tumour Flare during Interruption of Temsirolimus Treatment for Metastatic Renal Cell Cancer. Clinical Oncology, 21(9), pp. 732-733. (doi: 10.1016/j.clon.2009.07.006)

Jones, R. J. et al. (2009) Src inhibitors in early breast cancer: a methodology, feasibility and variability study. Breast Cancer Research and Treatment, 114(2), pp. 211-221. (doi: 10.1007/s10549-008-9997-1)

Jones, R., Hawkins, R., Eatock, M., Ferry, D., Eskens, F., Wilke, H. and Evans, T. (2008) A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma. Cancer Chemotherapy and Pharmacology, 61(3), pp. 435-441. (doi: 10.1007/s00280-007-0486-8)

Twelves, C., Trigo, J. M., Jones, R. , De Rosa, F., Rakhit, A., Fettner, S., Wright, T. and Baselga, J. (2008) Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: a dose-escalation study. European Journal of Cancer, 44(3), pp. 419-426. (doi: 10.1016/j.ejca.2007.12.011)

Jones, R.J. , Boyce, T., Fennell, M., Jacobs, V., Pinto, F., Duffield, E., Clack, G., Green, T., Kelly, J. and Robertson, J. (2008) The impact of delay in cryo-fixation on biomarkers of Src tyrosine kinase activity in human breast and bladder cancers. Cancer Chemotherapy and Pharmacology, 61(1), pp. 23-32. (doi: 10.1007/s00280-007-0440-9)

Hanauske, A., Cassidy, J., Sastre, J., Bolling, C., Jones, R. , Rakhit, A., Fettner, S., Brennscheidt, U., Feyereislova, A. and Diaz-Rubio, E. (2007) Phase 1b dose escalation study of erlotinib in combination with infusional 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced solid tumors. Clinical Cancer Research, 13(2), pp. 523-531. (doi: 10.1158/1078-0432.CCR-06-1627)

MacPherson, I. , Jones, R. and Evans, T. (2007) Clinical development of src family kinase inhibitors in malignant melanoma. Open Cancer Journal, 2007(1), pp. 9-20. (doi: 10.2174/1874079000701010009)

Glen, H. and Jones, R.J. (2003) 8th international conference: primary therapy of early breast cancer, St Gallen, Switzerland, March 12-15 2003. Breast Cancer Research, 5(4), pp. 198-201. (doi: 10.1186/bcr611)

Jones, R. , Avizienyte, E., Wyke, A., Owens, D., Brunton, V. and Frame, M. (2002) Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM1 2C human colorectal cancer cells. British Journal of Cancer, 87(10), pp. 1128-1135. (doi: 10.1038/sj.bjc.6600594)

Avizienyte, E., Wyke, A., Jones, R. , McLean, G., Westhoff, M., Brunton, V. and Frame, M. (2002) Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nature Cell Biology, 4(8), pp. 632-638. (doi: 10.1038/ncb829)

Jones, R. and Twelves, C. (2002) Pemetrexed: a multitargeted antifolate (ALIMTA, LY-231514). Expert Review of Anticancer Therapy, 2(1), pp. 13-22. (doi: 10.1586/14737140.2.1.13)

Twelves, C. and Jones, R. (2001) Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil? Expert Opinion on Pharmacotherapy, 2(9), pp. 1495-1505. (doi: 10.1517/14656566.2.9.1495)

Book Sections

Jones, R. J. (2018) Neoadjuvant vs. adjuvant chemotherapy: which is right? In: Soria, F. and Gontero, P. (eds.) Treating Urothelial Bladder Cancer. Springer: Cham, pp. 75-81. ISBN 9783319785585 (doi:10.1007/978-3-319-78559-2_10)

Jones, R. J. (2018) The role of medical oncologist. In: Soria, F. and Gontero, P. (eds.) Treating Urothelial Bladder Cancer. Springer: Cham, pp. 119-122. ISBN 9783319785585 (doi:10.1007/978-3-319-78559-2_15)

Fulton, B. and Jones, R. J. (2016) Combination treatment strategies with docetaxel in patients with metastatic prostate. In: Balaji, K.C. (ed.) Managing Metastatic Prostate Cancer In Your Urological Oncology Practice. Springer: Cham, pp. 93-105. ISBN 9783319313399 (doi:10.1007/978-3-319-31341-2_7)

Jones, R.J. , Green, T.P. and Elvin, P. (2011) Discovery and development of drugs targeting tumour invasion and metastasis. In: Lyden, D., Welch, D.R. and Psaila, B. (eds.) Cancer Metastasis: Biologic Basis and Therapeutics. Cambridge University Press, pp. 600-611. ISBN 9780521887212

Conference or Workshop Item

Bilsland, A. , Kelly, C., Roccisana, J., Paul, J. , Jones, R. , Edwards, J. , Roseweir, A. , Stein, T. and West, K. (2018) An Exploratory Study on the Use of Game-based Learning Using Microsoft Kinect to Teach Oncology Phase I Clinical Trial Designs. 2018 NCRI Cancer Conference, Glasgow, UK, 04-06 Nov 2018. (doi:10.1038/s41416-018-0299-z)

This list was generated on Thu Jun 4 19:38:36 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • PREDICT-Meso: PRE-malignant Drivers Combined with Target-Drug validation in Mesothelioma
    Cancer Research UK
    2020 - 2021
     
  • MARKERS AND MEDIATORS OF ANGIOGENESIS INHIBITOR-INDUCED VASCULAR AND MYOCARDIAL TOXICITY: A Prospective Study in Patients with Cancer
    British Heart Foundation
    2019 - 2021
     
  • ECMC supplement
    Chief Scientist Office
    2019 - 2020
     
  • TRANS CeNturIOn
    Cancer Research UK (CRUK)
    2019 - 2019
     
  • TASTER (TArgeting STEm cell Resistance) - Defining leukaemic cell clonal architecture to inform and monitor drug responses in the TASTER CML Phase II Clinical Trial
    Cancer Research UK
    2018 - 2019
     
  • Glasgow ECMC
    Cancer Research UK
    2017 - 2018
     
  • Glasgow ECMC
    Chief Scientist Office
    2017 - 2018
     
  • Precision-Panc: a dynamic therapeutic development platform for pancreatic cancer
    Cancer Research UK
    2017 - 2019
     
  • Real-world experience of Radum-223 in metastatic castration resistant prostate cancer, a UK study
    Bayer plc
    2017 - 2019
     
  • Real-world experience of Radum-223 in metastatic castration resistant prostate cancer, a UK study
    NHS Greater Glasgow and Clyde
    2017 - 2020
     
  • PARADIGM-2: Olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in newly diagnosed glioblastoma stratified by MGMT status: 2 parallel phase I studies
    Cancer Research UK
    2016 - 2020
     
  • ATLANTIS - Maintaining response in Urothelial Cancer: A Personalised Medicine Trial
    Cancer Research UK
    2016 - 2017
     
  • A clinical research fellowship in cancer clinical trials
    Cancer Research UK
    2015 - 2017
     
  • Combined Suppression of cholesterol bioavailability and androgen de novo syntheseis to treat castrate resistant prostate cancer
    Prostate Cancer UK
    2015 - 2019
     
  • Evaluating cancer services across the NHS in Scotland, Wales and Northern Ireland.
    Cancer Research UK
    2015 - 2016
     
  • Optimising the use of chemotherapy in prostate cancer
    Prostate Cancer Research Foundation
    2015 - 2018
     
  • Investment to support purchase of electronic remote data capture (eRDC) system for clinical trials
    Cancer Research UK
    2015 - 2017
     
  • Cancer Research UK Clinical Trials Unit - Core Programme Funding
    Cancer Research UK
    2013 - 2018
     
  • The effect of Dasatinib administration on metastases gene expression in early and late stage prostate cancer in vitro
    Cancer Research UK
    2012 - 2013
     
  • MAdCaP: Mdm2 inhibition and Abiraterone in Carcinoma of the Prostate - a randomized phase II trial of abiraterone acetate with or without RO5045337
    Cancer Research UK
    2012 - 2016
     
  • CROP Imaging substudy to the main trial (A randomised controlled trial of deferred androgen deprivation therapy +/- upfront cryotherapy in men with localised radiation recurrent prostate cancer.
    Cancer Research UK
    2012 - 2013
     
  • A randomised controlled trial of deferred androgen deprivation therapy +/- upfront cryotherapy in men with localised radiation recurrent prostate cancer (RRPC) to evaluate efficacy and tolerability
    Cancer Research UK
    2011 - 2013
     
  • Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC): proteomic reconstruction of molecular pathways to predict renal cell cancer recurrence and response to treatment
    Chief Scientist Office
    2010 - 2013
     
  • Biomarkers of Invasion: Methodology, feasibility and pre-clinical modelling
    NHS Greater Glasgow and Clyde Endowment Funds
    2007 - 2010
     

Research datasets

Jump to: 2019
Number of items: 1.

2019

Ross, K., Keith, N. , Aitchison, I., Allbutt, E., Banks, E., Basra, S., Bilsland, A., Charalambous, A., Chapal, C., Drummond, M., Dunipace, S., Erridge, A., Fremin-Besombes, M., Glasspool, R., Hamilton, V., Hanna, C. , Herfurth, L., Humpleby, M., Hush, G., Ivanova, Y., Jones, R. , Kaleta-Pyrek, A., Kalt, L., Kantor, M., Karolak, G., Keith, A., Klink, S., Laing, B., Lister, A., Mallon, E., Mccann, E., McLaughlin, R., Merchant, Z., Mozel, A., Mrozek, O., Painter, C., Paul, J. , Paxton, J., Perry, M. , Prendergast, E., Proudfoot, B., Raina, T., Roberts, F., Safrany, S., Scott, J., Sleight, R., Smith, C., Strain, E., Stricevic, M., Svanera, S., Tobias, E. , Vansteenhouse, H., Williams, N. and Zhang, H. (2019) A collaborative approach to exploring the future of Cancer treatment and care in relation to Precision Medicine: A design perspective. [Data Collection]

This list was generated on Thu Jun 4 19:38:38 2020 BST.