Dr Katie Wakeham

  • Honorary Lecturer (Institute of Cancer Sciences)

Research interests

Research Interests

The epidemiology of HPV-associated ano-genital and oropharyngeal cancers is under going substantial change. Cervical cancer remains a major public health concern, particular in resource-limited settings.  Evidence suggests that cancers associated with HPV, including oropharyngeal and vulval malignancies, may be increasing in incidence. The change in occurrence of these cancers may reflect an increase in HPV transmission. The screening programme and the HPV vaccine offer optimism that HPV-associated cancers can in the future be prevented. 

To investigate the future burden of all HPV-associated cancers and the potential impact of both HPV vaccination and screening, a collaboration has been established between Professor Sheila Graham, Centre for Virus Research, University of Glasgow, Dr Kate Cuschieri, Scottish HPV Reference Laboratory, Royal Infirmary of Edinburgh, Dr David Millan, Department of Pathology, Southern General Hospital, Glasgow and Dr Kimberly Kavanagh, Statistics, University of Strathclyde.  We are members of the Scottish HPV Investigators’ Network (http://www.shine.mvm.ed.ac.uk/). Further work on the development of screening strategies for risk stratification of HPV-associated pre-cancers and malignancies among high-risk groups is underway in well-characterised cohorts, as is HPV-associated biomarker testing for oropharyngeal, anal and vulval cancers.  These research projects benefit from the wealth of biological samples and data held in the NHS Research Scotland’s national tissue bank and Information Services Division, NHS National Services Scotland.

Additional information

Clinician in Clinical Oncology
Beatson West of Scotland Cancer Centre
1053 Great Western Road
Glasgow
G12 0YN


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • The epidemiology and significance of human papillomavirus in anal intraepithelial neoplasia and anal cancer.
    Academy of Medical Sciences
    2014 - 2016
     
  • The prognostic significance of HPV in vulvar intraepithelial neoplasia and vulvar cancer.
    Beatson Oncology Fund
    2013 - 2016
     
  • The epidemiology of human papillomavirus associated oropharyngeal cancers in the west of Scotland
    Cancer Research UK
    2012 - 2013
     

Publications

List by: Type | Date

Jump to: 2019 | 2017 | 2015 | 2014 | 2013 | 2011 | 2010 | 2006 | 2005
Number of items: 18.

2019

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, (doi:10.1002/ijc.32126) (PMID:30650180) (Early Online Publication)

Wakeham, K. et al. (2019) A prospective cohort study of HPV-driven oropharyngeal cancers; implications for prognosis and immunisation. Clinical Oncology, (Accepted for Publication)

2017

Rawstron, A. C. et al. (2017) Monoclonal B-cell lymphocytosis in a hospital-based UK population and a rural Ugandan population: a cross-sectional study. Lancet Haematology, 4(7), e334-e340. (doi:10.1016/S2352-3026(16)30192-2) (PMID:28668191) (PMCID:PMC5493519)

Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K. G., Bell, S., Burton, K., Reed, N. S. and Graham, S. V. (2017) HPV status and favorable outcome in vulvar squamous cancer. International Journal of Cancer, 140(5), pp. 1134-1146. (doi:10.1002/ijc.30523) (PMID:27864932)

Sallah, N. et al. (2017) Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot. Global Health, Epidemiology and Genomics, 2, e18. (doi:10.1017/gheg.2017.16) (PMID:29868224) (PMCID:PMC5870407)

2015

Parkes-Ratanshi, R., Katende, D., Levin, J., Wakeham, K., Heiner, G., Kamali, A. and Lalloo, D. G. (2015) Development of severe anemia and changes in hemoglobin in a cohort of HIV-infected Ugandan adults receiving zidovudine-, stavudine-, and tenofovir-containing antiretroviral regimens. Journal of the International Association of Providers of AIDS Care, 14(5), pp. 455-462. (doi:10.1177/2325957414557264) (PMID:25425638)

Wakeham, K., Johnston, W. T., Nalwoga, A., Webb, E. L., Mayanja, B. N., Miley, W., Elliott, A. M., Whitby, D. and Newton, R. (2015) Trends in Kaposi's sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study. International Journal of Cancer, 136(12), pp. 2822-2830. (doi:10.1002/ijc.29329) (PMID:25395177)

Nalwoga, A., Cose, S., Wakeham, K., Miley, W., Ndibazza, J., Drakeley, C., Elliott, A., Whitby, D. and Newton, R. (2015) Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda. Tropical Medicine and International Health, 20(5), pp. 665-672. (doi:10.1111/tmi.12464) (PMID:25611008)

2014

Wakeham, K. and Kavanagh, K. (2014) The burden of HPV-associated anogenital cancers. Current Oncology Reports, 16(9), p. 402. (doi:10.1007/s11912-014-0402-4)

Asiki, G. et al. (2014) A pilot study to evaluate aflatoxin exposure in a rural Ugandan population. Tropical Medicine and International Health, 19(5), pp. 592-599. (doi:10.1111/tmi.12283) (PMID:24612197)

2013

Wakeham, K. et al. (2013) Risk factors for seropositivity to Kaposi sarcoma‚Äďassociated herpesvirus among children in Uganda. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 63(2), pp. 228-233. (doi:10.1097/QAI.0b013e31828a7056)

2011

Parkes-Ratanshi, R., Wakeham, K., Levin, J., Namusoke, D., Whitworth, J., Coutinho, A., Mugisha, N. K., Grosskurth, H., Kamali, A. and Lalloo, D. G. (2011) Primary prophylaxis of cryptococcal disease with fluconazole in HIV-positive Ugandan adults: a double-blind, randomised, placebo-controlled trial. Lancet Infectious Diseases, 11(12), pp. 933-941. (doi:10.1016/S1473-3099(11)70245-6) (PMID:21982529)

Wakeham, K., Webb, E. L., Sebina, I., Muhangi, L., Miley, W., Johnson, W. T., Ndibazza, J., Elliott, A. M., Whitby, D. and Newton, R. (2011) Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infectious Agents and Cancer, 6(1), p. 15. (doi:10.1186/1750-9378-6-15)

2010

Wakeham, K., Harding, R., Bamukama-Namakoola, D., Levin, J., Kissa, J., Parkes-Ratanshi, R., Muzaaya, G., Grosskurth, H. and Lalloo, D. G. (2010) Symptom burden in HIV-infected adults at time of HIV diagnosis in rural Uganda. Journal of Palliative Medicine, 13(4), pp. 375-380. (doi:10.1089/jpm.2009.0259)

Namakoola, I., Wakeham, K., Parkes-Ratanshi, R., Levin, J., Mugagga, T., Seymour, C., Kissa, J.., Kamali, A. and Lalloo, D. G. (2010) Use of nail and oral pigmentation to determine ART eligibility among HIV-infected Ugandan adults. Tropical Medicine and International Health, 15(2), pp. 259-262. (doi:10.1111/j.1365-3156.2009.02448.x)

Wakeham, K., Parkes-Ratanshi, R., Watson, V., Ggayi, A.-B., Khoo, S. and Lalloo, D. G. (2010) Co-administration of fluconazole increases nevirapine concentrations in HIV-infected Ugandans. Journal of Antimicrobial Chemotherapy, 65(2), pp. 316-319. (doi:10.1093/jac/dkp451) (PMID:20032007) (PMCID:PMC2809247)

2006

Williams, M. and Wakeham, K. (2006) Radiotherapy might not be the answer in Africa. Lancet Oncology, 7(9), p. 705. (doi:10.1016/S1470-2045(06)70840-3)

2005

Kojodjojo, P., Chew, S., Wakeham, K. and Lancaster, R. (2005) Splenomegaly, anaemia and pleural effusion. Journal of the Royal Society of Medicine, 98(1), pp. 23-24. (doi:10.1258/jrsm.98.1.23) (PMID:15632233) (PMCID:PMC1079235)

This list was generated on Wed Jun 19 22:59:26 2019 BST.
Jump to: Articles
Number of items: 18.

Articles

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, (doi:10.1002/ijc.32126) (PMID:30650180) (Early Online Publication)

Wakeham, K. et al. (2019) A prospective cohort study of HPV-driven oropharyngeal cancers; implications for prognosis and immunisation. Clinical Oncology, (Accepted for Publication)

Rawstron, A. C. et al. (2017) Monoclonal B-cell lymphocytosis in a hospital-based UK population and a rural Ugandan population: a cross-sectional study. Lancet Haematology, 4(7), e334-e340. (doi:10.1016/S2352-3026(16)30192-2) (PMID:28668191) (PMCID:PMC5493519)

Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K. G., Bell, S., Burton, K., Reed, N. S. and Graham, S. V. (2017) HPV status and favorable outcome in vulvar squamous cancer. International Journal of Cancer, 140(5), pp. 1134-1146. (doi:10.1002/ijc.30523) (PMID:27864932)

Sallah, N. et al. (2017) Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot. Global Health, Epidemiology and Genomics, 2, e18. (doi:10.1017/gheg.2017.16) (PMID:29868224) (PMCID:PMC5870407)

Parkes-Ratanshi, R., Katende, D., Levin, J., Wakeham, K., Heiner, G., Kamali, A. and Lalloo, D. G. (2015) Development of severe anemia and changes in hemoglobin in a cohort of HIV-infected Ugandan adults receiving zidovudine-, stavudine-, and tenofovir-containing antiretroviral regimens. Journal of the International Association of Providers of AIDS Care, 14(5), pp. 455-462. (doi:10.1177/2325957414557264) (PMID:25425638)

Wakeham, K., Johnston, W. T., Nalwoga, A., Webb, E. L., Mayanja, B. N., Miley, W., Elliott, A. M., Whitby, D. and Newton, R. (2015) Trends in Kaposi's sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study. International Journal of Cancer, 136(12), pp. 2822-2830. (doi:10.1002/ijc.29329) (PMID:25395177)

Nalwoga, A., Cose, S., Wakeham, K., Miley, W., Ndibazza, J., Drakeley, C., Elliott, A., Whitby, D. and Newton, R. (2015) Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda. Tropical Medicine and International Health, 20(5), pp. 665-672. (doi:10.1111/tmi.12464) (PMID:25611008)

Wakeham, K. and Kavanagh, K. (2014) The burden of HPV-associated anogenital cancers. Current Oncology Reports, 16(9), p. 402. (doi:10.1007/s11912-014-0402-4)

Asiki, G. et al. (2014) A pilot study to evaluate aflatoxin exposure in a rural Ugandan population. Tropical Medicine and International Health, 19(5), pp. 592-599. (doi:10.1111/tmi.12283) (PMID:24612197)

Wakeham, K. et al. (2013) Risk factors for seropositivity to Kaposi sarcoma‚Äďassociated herpesvirus among children in Uganda. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 63(2), pp. 228-233. (doi:10.1097/QAI.0b013e31828a7056)

Parkes-Ratanshi, R., Wakeham, K., Levin, J., Namusoke, D., Whitworth, J., Coutinho, A., Mugisha, N. K., Grosskurth, H., Kamali, A. and Lalloo, D. G. (2011) Primary prophylaxis of cryptococcal disease with fluconazole in HIV-positive Ugandan adults: a double-blind, randomised, placebo-controlled trial. Lancet Infectious Diseases, 11(12), pp. 933-941. (doi:10.1016/S1473-3099(11)70245-6) (PMID:21982529)

Wakeham, K., Webb, E. L., Sebina, I., Muhangi, L., Miley, W., Johnson, W. T., Ndibazza, J., Elliott, A. M., Whitby, D. and Newton, R. (2011) Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infectious Agents and Cancer, 6(1), p. 15. (doi:10.1186/1750-9378-6-15)

Wakeham, K., Harding, R., Bamukama-Namakoola, D., Levin, J., Kissa, J., Parkes-Ratanshi, R., Muzaaya, G., Grosskurth, H. and Lalloo, D. G. (2010) Symptom burden in HIV-infected adults at time of HIV diagnosis in rural Uganda. Journal of Palliative Medicine, 13(4), pp. 375-380. (doi:10.1089/jpm.2009.0259)

Namakoola, I., Wakeham, K., Parkes-Ratanshi, R., Levin, J., Mugagga, T., Seymour, C., Kissa, J.., Kamali, A. and Lalloo, D. G. (2010) Use of nail and oral pigmentation to determine ART eligibility among HIV-infected Ugandan adults. Tropical Medicine and International Health, 15(2), pp. 259-262. (doi:10.1111/j.1365-3156.2009.02448.x)

Wakeham, K., Parkes-Ratanshi, R., Watson, V., Ggayi, A.-B., Khoo, S. and Lalloo, D. G. (2010) Co-administration of fluconazole increases nevirapine concentrations in HIV-infected Ugandans. Journal of Antimicrobial Chemotherapy, 65(2), pp. 316-319. (doi:10.1093/jac/dkp451) (PMID:20032007) (PMCID:PMC2809247)

Williams, M. and Wakeham, K. (2006) Radiotherapy might not be the answer in Africa. Lancet Oncology, 7(9), p. 705. (doi:10.1016/S1470-2045(06)70840-3)

Kojodjojo, P., Chew, S., Wakeham, K. and Lancaster, R. (2005) Splenomegaly, anaemia and pleural effusion. Journal of the Royal Society of Medicine, 98(1), pp. 23-24. (doi:10.1258/jrsm.98.1.23) (PMID:15632233) (PMCID:PMC1079235)

This list was generated on Wed Jun 19 22:59:26 2019 BST.