Professor Kevin Ryan

  • Professor (Beatson Institute for Cancer Research)

Research interests

The aim of our group is to understand the factors regulating programmed cell death in cancer cells. Since it is known that inhibition of cell death mechanisms is a common event in tumour development, this poses problems for many forms of chemotherapy which utilize cell death pathways, leading to drug resistance. We are investigating both known cell death regulators as well as searching for novel proteins that control cell death and chemosensitivity. We envisage that the knowledge gained from our studies will be translated and lead to the improvement of existing clinical regimens or new targets for therapeutic intervention.

Link to Tumour Cell Death website


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Characterising a novel oncogenic mechanism of the major human viral carcinogen: human papillomavirus 16 (HPV16) E2 suppresses the p53 response
    Cancer Research UK
    2010 - 2012
     
  • Functional studies of autophagy for in vivo survival of CML stem cells
    Cancer Research UK
    2010 - 2012
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 84.

2018

Baquero, P. et al. (2018) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, (doi:10.1038/s41375-018-0252-4) (PMID:30185934) (Early Online Publication)

Riley, J. S. et al. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37(17), e99238. (doi:10.15252/embj.201899238) (PMID:30049712) (PMCID:PMC6120664)

Mitchell, R. et al. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110(5), pp. 467-478. (doi:10.1093/jnci/djx236) (PMID:29165716)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi:10.1038/s41419-017-0035-2) (PMID:29339815)

Deretic, V. et al. (2018) Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 14(6), pp. 925-929. (doi:10.1080/15548627.2018.1465784) (PMID:29938597)

Sierra Gonzalez, P. et al. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi:10.1038/s41586-018-0729-3) (PMID:30464341)

2017

Sakamaki, J.-I., Long, J. S., New, M., Van Acker, T., Tooze, S. A. and Ryan, K. M. (2017) Emerging roles of transcriptional programs in autophagy regulation. Transcription, 9(2), pp. 131-136. (doi:10.1080/21541264.2017.1372045) (PMID:28980873)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi:10.1038/ncb3596) (PMID:28846096)

Galluzzi, L. et al. (2017) Molecular definitions of autophagy and related processes. EMBO Journal, 36(13), pp. 1811-1836. (doi:10.15252/embj.201796697) (PMID:28596378)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi:10.1038/cdd.2016.120) (PMID:28106883)

Simon, H.-U., Friis, R., Tait, S. W.G. and Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10(468), eaag2791. (doi:10.1126/scisignal.aag2791) (PMID:28246201)

Sakamaki, J.-I. and Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13(11), pp. 2006-2007. (doi:10.1080/15548627.2017.1364822) (PMID:28933601)

2016

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K., Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi:10.1021/acs.jproteome.6b00166) (PMID:27246970)

Sakamaki, J.-i. and Ryan, K. M. (2016) Autophagy determines the path on the TRAIL to death. Developmental Cell, 37(4), pp. 291-293. (doi:10.1016/j.devcel.2016.05.010) (PMID:27219055)

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P. and Ryan, K. M. (2016) p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death. Cell Cycle, 15(17), pp. 2299-2308. (doi:10.1080/15384101.2016.1191714) (PMID:27315169) (PMCID:PMC5004703)

Gillespie, D. A. and Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3(1), e1030538. (doi:10.1080/23723556.2015.1030538) (PMID:27308547) (PMCID:PMC4845186)

Klionsky, D. J. et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. (doi:10.1080/15548627.2015.1100356) (PMID:26799652) (PMCID:PMC4835977)

Mrschtik, M. and Ryan, K. M. (2016) Another DRAM involved in autophagy and cell death. Autophagy, 12(3), pp. 603-605. (doi:10.1080/15548627.2015.1137412) (PMID:27046253) (PMCID:PMC4836028)

2015

Graczyk, D., White, R. and Ryan, K. (2015) Involvement of RNA polymerase III in immune responses. Molecular and Cellular Biology, 35(10), pp. 1848-1859. (doi:10.1128/MCB.00990-14) (PMID:25776554)

Mrschtik, M. and Ryan, K. M. (2015) Lysosomal proteins in cell death and autophagy. FEBS Journal, 282(10), pp. 1858-1870. (doi:10.1111/febs.13253) (PMID:25735653)

Baudot, A., Haller, M., Mrschtik, M., Tait, S. and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi:10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Liu, E. Y. et al. (2015) Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proceedings of the National Academy of Sciences of the United States of America, 112(3), pp. 773-778. (doi:10.1073/pnas.1409563112)

Galluzzi, L. et al. (2015) Autophagy in malignant transformation and cancer progression. EMBO Journal, 34(7), pp. 856-880. (doi:10.15252/embj.201490784) (PMID:25712477) (PMCID:PMC4388596)

Long, J.S., Schoonen, P.M., Graczyk, D., O'Prey, J. and Ryan, K. (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene, 34(40), pp. 5152-5162. (doi:10.1038/onc.2014.436) (PMID:25659586)

Mrschtik, M., O'Prey, J., Lao, L.Y., Long, J.S., Beaumatin, F., Strachan, D., O'Prey, M., Skommer, J. and Ryan, K.M. (2015) DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Cell Death and Differentiation, 22(10), pp. 1714-1726. (doi:10.1038/cdd.2015.26) (PMID:25929859) (PMCID:PMC4563785)

2014

Klionsky, D. J. et al. (2014) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), pp. 445-544. (doi:10.4161/auto.19496) (PMID:22966490) (PMCID:PMC3404883)

Joshi, S. and Ryan, K.M. (2014) Autophagy chews Fap to promote apoptosis. Nature Cell Biology, 16(1), pp. 23-25. (doi:10.1038/ncb2899)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M. , Vousden, K. H. and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi:10.4161/15548627.2014.981914) (PMID:25629932)

Rosenfeldt, M.T., Bell, L.A., Long, J.S., O'Prey, J., Nixon, C., Roberts, F., Dufès, C. and Ryan, K.M. (2014) E2F1 drives chemotherapeutic drug resistance via ABCG2. Oncogene, 33(32), pp. 4164-4172. (doi:10.1038/onc.2013.470)

2013

Macintosh, R.L. and Ryan, K.M. (2013) Autophagy in tumour cell death. Seminars in Cancer Biology, 23(5), pp. 344-351. (doi:10.1016/j.semcancer.2013.05.006)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi:10.1016/j.molcel.2013.03.016)

Bennett, H.L., Stockley, J., Fleming, J.T., Mandal, R., O'Prey, J., Ryan, K.M. , Robson, C.N. and Leung, H.Y. (2013) Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells? BJU International, 111(4), pp. 672-682. (doi:10.1111/j.1464-410X.2012.11409.x)

Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi:10.1158/2159-8290.CD-12-0292)

Helgason, G.V. , Holyoake, T.L. and Ryan, K.M. (2013) Role of autophagy in cancer prevention, development and therapy. Essays in Biochemistry, 55(1), pp. 133-151. (doi:10.1042/BSE0550133)

Ramirez-Peinado, S., Leon-Annicchiarico, C. L., Galindo-Moreno, J., Iurlaro, R., Caro-Maldonado, A., Prehn, J. H.M., Ryan, K. M. and Munoz-Pinedo, C. (2013) Glucose-starved cells do not engage in prosurvival autophagy. Journal of Biological Chemistry, 288(42), pp. 30387-30398. (doi:10.1074/jbc.M113.490581)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi:10.1038/nature12865)

2012

Liu, E.Y. and Ryan, K.M. (2012) Autophagy and cancer - issues we need to digest. Journal of Cell Science, 125(10), pp. 2349-2358.

Ladoire, S. et al. (2012) Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy, 8(8), pp. 1175-1184. (doi:10.4161/auto.20353)

Lemarié, F., Croft, D.R., Tate, R.J., Ryan, K.M. and Dufès, C. (2012) Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system. Biomaterials, 33(9), pp. 2701-2709. (doi:10.1016/j.biomaterials.2011.12.019)

Long, J.S. and Ryan, K.M. (2012) New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene, 31(49), pp. 5045-5060. (doi:10.1038/onc.2012.7)

Mah, L.Y. and Ryan, K.M. (2012) Autophagy and cancer. Cold Spring Harbor Perspectives in Biology, 4(1), a008821-a008821. (doi:10.1101/cshperspect.a008821)

2011

Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi:10.1038/cr.2010.154)

Baudot, A.D. and Ryan, K.M. (2011) p53 and tumor surveillance: killer finds way to recruit assassins. Cell Cycle, 10(22), p. 3818. (doi:10.4161/cc.10.22.18191)

Rosenfeldt, M.T. and Ryan, K.M. (2011) The multiple roles of autophagy in cancer. Carcinogenesis, 32(7), pp. 955-963. (doi:10.1093/carcin/bgr031)

Ryan, K.M. (2011) p53 and autophagy in cancer: Guardian of the genome meets guardian of the proteome. European Journal of Cancer, 47(1), pp. 44-50. (doi:10.1016/j.ejca.2010.10.020)

Stindt, M.H., Carter, S., Vigneron, A.M., Ryan, K.M. and Vousden, K.H. (2011) MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle, 10(18), pp. 3176-3188. (doi:10.4161/cc.10.18.17436)

Wilkinson, S., Croft, D.R., O’Prey, J., Meedendorp, A., O’Prey, M., Dufès, C. and Ryan, K.M. (2011) The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy. Autophagy, 7(11), pp. 1295-1301. (doi:10.4161/auto.7.11.16646)

2010

Long, J.S. and Ryan, K.M. (2010) p53 and senescence: a little goes a long way. Cell Cycle, 9(20), pp. 4050-4051. (doi:10.4161/cc.9.20.13747)

Bennett, H.L., Fleming, J.T., O'Prey, J., Ryan, K.M. and Leung, H.Y. (2010) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death and Disease, 1(9), e72. (doi:10.1038/cddis.2010.50)

Fricker, M., O'Prey, J., Tolkovsky, A.M. and Ryan, K.M. (2010) Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death and Disease, 1(7), e59. (doi:10.1038/cddis.2010.38)

Helgason, G.V. , O'Prey, J. and Ryan, K.M. (2010) Oncogene-induced sensitization to chemotherapy-induced death requires induction as well as deregulation of E2F1. Cancer Research, 70(10), pp. 4074-4080. (doi:10.1158/0008-5472.CAN-09-2876)

Huser, C.A., Pringle, M.A., Heath, V.J., Bell, A.K., Kendrick, H., Smalley, M.J., Crighton, D., Ryan, K.M. , Gusterson, B.A. and Stein, T. (2010) TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death and Differentiation, 17(2), pp. 304-315. (doi:10.1038/cdd.2009.126)

Lorin, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2010) Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy. Autophagy, 6(1), pp. 153-154. (doi:10.4161/auto.6.1.10537)

O'Prey, J., Crighton, D., Martin, A., Vousden, K., Fearnhead, H. and Ryan, K. (2010) p53-mediated induction of Noxa and p53AIP1 requires NF kappa B. Cell Cycle, 9(5), pp. 947-952.

Ryan, K.M. (2010) Cancer: Viruses' backup plan. Nature, 466(7310), pp. 1054-1055. (doi:10.1038/4661054a)

Wilkinson, S. and Ryan, K.M. (2010) Autophagy: an adaptable modifier of tumourigenesis. Current Opinion in Genetics and Development, 20(1), pp. 57-64. (doi:10.1016/j.gde.2009.12.004)

2009

Lorin, S., Borges, A., Ribeiro Dos Santos, L., Souquere, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2009) c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells. Cancer Research, 69(17), pp. 6924-6931. (doi:10.1158/0008-5472.CAN-09-1270)

Martin, A.G., Trama, J., Crighton, D., Ryan, K.M. and Fearnhead, H.O. (2009) Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Aging, 1(3), pp. 335-349.

O'Prey, J., Skommer, J., Wilkinson, S. and Ryan, K.M. (2009) Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle, 8(14), pp. 2260-2265. (doi:10.4161/cc.8.14.9050)

Rosenfeldt, M.T. and Ryan, K.M. (2009) The role of autophagy in tumour development and cancer therapy. Expert Reviews in Molecular Medicine, 11, e36. (doi:10.1017/S1462399409001306)

Vousden, K. and Ryan, K. (2009) p53 and metabolism. Nature Reviews Cancer, 9(10), pp. 691-700. (doi:10.1038/nrc2715)

Wilkinson, S., O'Prey, J., Fricker, M. and Ryan, K.M. (2009) Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes and Development, 23(11), pp. 1283-1288. (doi:10.1101/gad.521709)

Wilkinson, S. and Ryan, K.M. (2009) Growth factor signaling permits hypoxia-induced autophagy by a HIF1 alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells. Autophagy, 5(7), pp. 1068-1069.

Yee, K., Wilkinson, S., James, J., Ryan, K. and Vousden, K. (2009) PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death and Differentiation, 16(8), pp. 1135-1145. (doi:10.1038/cdd.2009.28)

2008

Bell, H. and Ryan, K. (2008) iASPP inhibition: Increased options in targeting the p53 family for cancer therapy. Cancer Research, 68(13), pp. 4959-4962. (doi:10.1158/0008-5472.CAN-08-0182)

O'Prey, J., Wilkinson, S. and Ryan, K.M. (2008) Tumor Antigen LRRC15 Impedes Adenoviral Infection: Implications for Virus-Based Cancer Therapy. Journal of Virology, 82(12), pp. 5933-5939. (doi:10.1128/JVI.02273-07)

Park, M. et al. (2008) Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biology and Therapy, 7(10), pp. 1648-1662.

2007

Bell, H., Dufes, C., O'Prey, J., Crighton, D., Bergamaschi, D., Lu, X., Schatzlein, A., Vousden, K. and Ryan, K. (2007) A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. Journal of Clinical Investigation, 117, pp. 1008-1018. (doi:10.1172/JCI28920)

Bell, H. and Ryan, K. (2007) Targeting the p53 family for cancer therapy - 'Big brother' joins the fight. Cell Cycle, 6(16), pp. 1995-2000. (doi:10.4161/cc.6.16.4614)

Crighton, D., Wilkinson, S. and Ryan, K. (2007) DRAM links autophagy to p53 and programmed cell death. Autophagy, 3(1), pp. 72-74.

Crighton, D., O'Prey, J., Bell, H.S. and Ryan, K.M. (2007) p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death and Differentiation, 14(6), pp. 1071-1079. (doi:10.1038/sj.cdd.4402108)

Ewings, K.E. and Ryan, K.M. (2007) Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression. Cell Research, 17(10), pp. 829-831. (doi:10.1038/cr.2007.85)

2006

Bell, L.A., O'Prey, J. and Ryan, K.M. (2006) DNA-binding independent cell death from a minimal proapoptotic region of E2F-1. Oncogene, 25(41), pp. 5656-5663. (doi:10.1038/sj.onc.1209580)

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., Gasco, M., Garrone, O., Crook, T. and Ryan, K. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell, 126(1), pp. 121-134. (doi:10.1016/j.cell.2006.05.034)

2005

Bell, H. and Ryan, K. (2005) Intracellular signalling and cancer: complex pathways lead to multiple targets. European Journal of Cancer, 41(2), pp. 206-215. (doi:10.1016/j.ejca.2004.10.022)

2004

Bell, L. and Ryan, K. (2004) Life and death decisions by E2F-1. Cell Death and Differentiation, 11(2), pp. 137-142. (doi:10.1038/sj.cdd.4401324)

Crighton, D. and Ryan, K.M. (2004) Splicing DNA-damage responses to turnour cell death. Biochimica et Biophysica Acta: Reviews on Cancer, 1705(1), pp. 3-15. (doi:10.1016/j.bbcan.2004.09.001)

Ryan, K. , O'Prey, J. and Vousden, K. (2004) Loss of nuclear factor-KB is tumor promoting but does not substitute for loss of p53. Cancer Research, 64(13), pp. 4415-4418. (doi:10.1158/0008-5472.CAN-04-1474)

Wang, W., Cassidy, J., O'Brien, V., Ryan, K. and Collie-Duguid, E. (2004) Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells. Cancer Research, 64(22), pp. 8167-8176. (doi:10.1158/0008-5472.CAN-04-0970)

2003

Gorgoulis, V.G., Zacharatos, P., Kotsinas, A., Kletsas, D., Mariatos, G., Zoumpourlis, V., Ryan, K.M. , Kittas, C. and Papavassiliou, A.G. (2003) p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO Journal, 22(7), pp. 1567-1578. (doi:10.1093/emboj/cdg157)

2002

Ryan, K. and Vousden, K. (2002) Cancer: Pinning a change on p53. Nature, 419(6909), pp. 795-797. (doi:10.1038/419795a)

2001

Baird, J. et al. (2001) Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. Journal of Biological Chemistry, 276(12), pp. 9189-9198. (doi:10.1074/jbc.M008354200)

Blagosklonny, M., Giannakakou, P., Romanova, L., Ryan, K. , Vousden, K. and Fojo, T. (2001) Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions. Carcinogenesis, 22(6), pp. 861-867. (doi:10.1093/carcin/22.6.861)

Ryan, K. , Phillips, A. and Vousden, K. (2001) Regulation and function of the p53 tumor suppressor protein. Current Opinion in Cell Biology, 13(3), pp. 332-337. (doi:10.1016/S0955-0674(00)00216-7)

This list was generated on Tue Jun 25 19:19:27 2019 BST.
Jump to: Articles
Number of items: 84.

Articles

Baquero, P. et al. (2018) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, (doi:10.1038/s41375-018-0252-4) (PMID:30185934) (Early Online Publication)

Riley, J. S. et al. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37(17), e99238. (doi:10.15252/embj.201899238) (PMID:30049712) (PMCID:PMC6120664)

Mitchell, R. et al. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110(5), pp. 467-478. (doi:10.1093/jnci/djx236) (PMID:29165716)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi:10.1038/s41419-017-0035-2) (PMID:29339815)

Deretic, V. et al. (2018) Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 14(6), pp. 925-929. (doi:10.1080/15548627.2018.1465784) (PMID:29938597)

Sierra Gonzalez, P. et al. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi:10.1038/s41586-018-0729-3) (PMID:30464341)

Sakamaki, J.-I., Long, J. S., New, M., Van Acker, T., Tooze, S. A. and Ryan, K. M. (2017) Emerging roles of transcriptional programs in autophagy regulation. Transcription, 9(2), pp. 131-136. (doi:10.1080/21541264.2017.1372045) (PMID:28980873)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi:10.1038/ncb3596) (PMID:28846096)

Galluzzi, L. et al. (2017) Molecular definitions of autophagy and related processes. EMBO Journal, 36(13), pp. 1811-1836. (doi:10.15252/embj.201796697) (PMID:28596378)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi:10.1038/cdd.2016.120) (PMID:28106883)

Simon, H.-U., Friis, R., Tait, S. W.G. and Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10(468), eaag2791. (doi:10.1126/scisignal.aag2791) (PMID:28246201)

Sakamaki, J.-I. and Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13(11), pp. 2006-2007. (doi:10.1080/15548627.2017.1364822) (PMID:28933601)

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K., Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi:10.1021/acs.jproteome.6b00166) (PMID:27246970)

Sakamaki, J.-i. and Ryan, K. M. (2016) Autophagy determines the path on the TRAIL to death. Developmental Cell, 37(4), pp. 291-293. (doi:10.1016/j.devcel.2016.05.010) (PMID:27219055)

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P. and Ryan, K. M. (2016) p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death. Cell Cycle, 15(17), pp. 2299-2308. (doi:10.1080/15384101.2016.1191714) (PMID:27315169) (PMCID:PMC5004703)

Gillespie, D. A. and Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3(1), e1030538. (doi:10.1080/23723556.2015.1030538) (PMID:27308547) (PMCID:PMC4845186)

Klionsky, D. J. et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. (doi:10.1080/15548627.2015.1100356) (PMID:26799652) (PMCID:PMC4835977)

Mrschtik, M. and Ryan, K. M. (2016) Another DRAM involved in autophagy and cell death. Autophagy, 12(3), pp. 603-605. (doi:10.1080/15548627.2015.1137412) (PMID:27046253) (PMCID:PMC4836028)

Graczyk, D., White, R. and Ryan, K. (2015) Involvement of RNA polymerase III in immune responses. Molecular and Cellular Biology, 35(10), pp. 1848-1859. (doi:10.1128/MCB.00990-14) (PMID:25776554)

Mrschtik, M. and Ryan, K. M. (2015) Lysosomal proteins in cell death and autophagy. FEBS Journal, 282(10), pp. 1858-1870. (doi:10.1111/febs.13253) (PMID:25735653)

Baudot, A., Haller, M., Mrschtik, M., Tait, S. and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi:10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Liu, E. Y. et al. (2015) Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proceedings of the National Academy of Sciences of the United States of America, 112(3), pp. 773-778. (doi:10.1073/pnas.1409563112)

Galluzzi, L. et al. (2015) Autophagy in malignant transformation and cancer progression. EMBO Journal, 34(7), pp. 856-880. (doi:10.15252/embj.201490784) (PMID:25712477) (PMCID:PMC4388596)

Long, J.S., Schoonen, P.M., Graczyk, D., O'Prey, J. and Ryan, K. (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene, 34(40), pp. 5152-5162. (doi:10.1038/onc.2014.436) (PMID:25659586)

Mrschtik, M., O'Prey, J., Lao, L.Y., Long, J.S., Beaumatin, F., Strachan, D., O'Prey, M., Skommer, J. and Ryan, K.M. (2015) DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Cell Death and Differentiation, 22(10), pp. 1714-1726. (doi:10.1038/cdd.2015.26) (PMID:25929859) (PMCID:PMC4563785)

Klionsky, D. J. et al. (2014) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), pp. 445-544. (doi:10.4161/auto.19496) (PMID:22966490) (PMCID:PMC3404883)

Joshi, S. and Ryan, K.M. (2014) Autophagy chews Fap to promote apoptosis. Nature Cell Biology, 16(1), pp. 23-25. (doi:10.1038/ncb2899)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M. , Vousden, K. H. and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi:10.4161/15548627.2014.981914) (PMID:25629932)

Rosenfeldt, M.T., Bell, L.A., Long, J.S., O'Prey, J., Nixon, C., Roberts, F., Dufès, C. and Ryan, K.M. (2014) E2F1 drives chemotherapeutic drug resistance via ABCG2. Oncogene, 33(32), pp. 4164-4172. (doi:10.1038/onc.2013.470)

Macintosh, R.L. and Ryan, K.M. (2013) Autophagy in tumour cell death. Seminars in Cancer Biology, 23(5), pp. 344-351. (doi:10.1016/j.semcancer.2013.05.006)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi:10.1016/j.molcel.2013.03.016)

Bennett, H.L., Stockley, J., Fleming, J.T., Mandal, R., O'Prey, J., Ryan, K.M. , Robson, C.N. and Leung, H.Y. (2013) Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells? BJU International, 111(4), pp. 672-682. (doi:10.1111/j.1464-410X.2012.11409.x)

Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi:10.1158/2159-8290.CD-12-0292)

Helgason, G.V. , Holyoake, T.L. and Ryan, K.M. (2013) Role of autophagy in cancer prevention, development and therapy. Essays in Biochemistry, 55(1), pp. 133-151. (doi:10.1042/BSE0550133)

Ramirez-Peinado, S., Leon-Annicchiarico, C. L., Galindo-Moreno, J., Iurlaro, R., Caro-Maldonado, A., Prehn, J. H.M., Ryan, K. M. and Munoz-Pinedo, C. (2013) Glucose-starved cells do not engage in prosurvival autophagy. Journal of Biological Chemistry, 288(42), pp. 30387-30398. (doi:10.1074/jbc.M113.490581)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi:10.1038/nature12865)

Liu, E.Y. and Ryan, K.M. (2012) Autophagy and cancer - issues we need to digest. Journal of Cell Science, 125(10), pp. 2349-2358.

Ladoire, S. et al. (2012) Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy, 8(8), pp. 1175-1184. (doi:10.4161/auto.20353)

Lemarié, F., Croft, D.R., Tate, R.J., Ryan, K.M. and Dufès, C. (2012) Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system. Biomaterials, 33(9), pp. 2701-2709. (doi:10.1016/j.biomaterials.2011.12.019)

Long, J.S. and Ryan, K.M. (2012) New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene, 31(49), pp. 5045-5060. (doi:10.1038/onc.2012.7)

Mah, L.Y. and Ryan, K.M. (2012) Autophagy and cancer. Cold Spring Harbor Perspectives in Biology, 4(1), a008821-a008821. (doi:10.1101/cshperspect.a008821)

Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi:10.1038/cr.2010.154)

Baudot, A.D. and Ryan, K.M. (2011) p53 and tumor surveillance: killer finds way to recruit assassins. Cell Cycle, 10(22), p. 3818. (doi:10.4161/cc.10.22.18191)

Rosenfeldt, M.T. and Ryan, K.M. (2011) The multiple roles of autophagy in cancer. Carcinogenesis, 32(7), pp. 955-963. (doi:10.1093/carcin/bgr031)

Ryan, K.M. (2011) p53 and autophagy in cancer: Guardian of the genome meets guardian of the proteome. European Journal of Cancer, 47(1), pp. 44-50. (doi:10.1016/j.ejca.2010.10.020)

Stindt, M.H., Carter, S., Vigneron, A.M., Ryan, K.M. and Vousden, K.H. (2011) MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle, 10(18), pp. 3176-3188. (doi:10.4161/cc.10.18.17436)

Wilkinson, S., Croft, D.R., O’Prey, J., Meedendorp, A., O’Prey, M., Dufès, C. and Ryan, K.M. (2011) The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy. Autophagy, 7(11), pp. 1295-1301. (doi:10.4161/auto.7.11.16646)

Long, J.S. and Ryan, K.M. (2010) p53 and senescence: a little goes a long way. Cell Cycle, 9(20), pp. 4050-4051. (doi:10.4161/cc.9.20.13747)

Bennett, H.L., Fleming, J.T., O'Prey, J., Ryan, K.M. and Leung, H.Y. (2010) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death and Disease, 1(9), e72. (doi:10.1038/cddis.2010.50)

Fricker, M., O'Prey, J., Tolkovsky, A.M. and Ryan, K.M. (2010) Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death and Disease, 1(7), e59. (doi:10.1038/cddis.2010.38)

Helgason, G.V. , O'Prey, J. and Ryan, K.M. (2010) Oncogene-induced sensitization to chemotherapy-induced death requires induction as well as deregulation of E2F1. Cancer Research, 70(10), pp. 4074-4080. (doi:10.1158/0008-5472.CAN-09-2876)

Huser, C.A., Pringle, M.A., Heath, V.J., Bell, A.K., Kendrick, H., Smalley, M.J., Crighton, D., Ryan, K.M. , Gusterson, B.A. and Stein, T. (2010) TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death and Differentiation, 17(2), pp. 304-315. (doi:10.1038/cdd.2009.126)

Lorin, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2010) Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy. Autophagy, 6(1), pp. 153-154. (doi:10.4161/auto.6.1.10537)

O'Prey, J., Crighton, D., Martin, A., Vousden, K., Fearnhead, H. and Ryan, K. (2010) p53-mediated induction of Noxa and p53AIP1 requires NF kappa B. Cell Cycle, 9(5), pp. 947-952.

Ryan, K.M. (2010) Cancer: Viruses' backup plan. Nature, 466(7310), pp. 1054-1055. (doi:10.1038/4661054a)

Wilkinson, S. and Ryan, K.M. (2010) Autophagy: an adaptable modifier of tumourigenesis. Current Opinion in Genetics and Development, 20(1), pp. 57-64. (doi:10.1016/j.gde.2009.12.004)

Lorin, S., Borges, A., Ribeiro Dos Santos, L., Souquere, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2009) c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells. Cancer Research, 69(17), pp. 6924-6931. (doi:10.1158/0008-5472.CAN-09-1270)

Martin, A.G., Trama, J., Crighton, D., Ryan, K.M. and Fearnhead, H.O. (2009) Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Aging, 1(3), pp. 335-349.

O'Prey, J., Skommer, J., Wilkinson, S. and Ryan, K.M. (2009) Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle, 8(14), pp. 2260-2265. (doi:10.4161/cc.8.14.9050)

Rosenfeldt, M.T. and Ryan, K.M. (2009) The role of autophagy in tumour development and cancer therapy. Expert Reviews in Molecular Medicine, 11, e36. (doi:10.1017/S1462399409001306)

Vousden, K. and Ryan, K. (2009) p53 and metabolism. Nature Reviews Cancer, 9(10), pp. 691-700. (doi:10.1038/nrc2715)

Wilkinson, S., O'Prey, J., Fricker, M. and Ryan, K.M. (2009) Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes and Development, 23(11), pp. 1283-1288. (doi:10.1101/gad.521709)

Wilkinson, S. and Ryan, K.M. (2009) Growth factor signaling permits hypoxia-induced autophagy by a HIF1 alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells. Autophagy, 5(7), pp. 1068-1069.

Yee, K., Wilkinson, S., James, J., Ryan, K. and Vousden, K. (2009) PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death and Differentiation, 16(8), pp. 1135-1145. (doi:10.1038/cdd.2009.28)

Bell, H. and Ryan, K. (2008) iASPP inhibition: Increased options in targeting the p53 family for cancer therapy. Cancer Research, 68(13), pp. 4959-4962. (doi:10.1158/0008-5472.CAN-08-0182)

O'Prey, J., Wilkinson, S. and Ryan, K.M. (2008) Tumor Antigen LRRC15 Impedes Adenoviral Infection: Implications for Virus-Based Cancer Therapy. Journal of Virology, 82(12), pp. 5933-5939. (doi:10.1128/JVI.02273-07)

Park, M. et al. (2008) Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biology and Therapy, 7(10), pp. 1648-1662.

Bell, H., Dufes, C., O'Prey, J., Crighton, D., Bergamaschi, D., Lu, X., Schatzlein, A., Vousden, K. and Ryan, K. (2007) A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. Journal of Clinical Investigation, 117, pp. 1008-1018. (doi:10.1172/JCI28920)

Bell, H. and Ryan, K. (2007) Targeting the p53 family for cancer therapy - 'Big brother' joins the fight. Cell Cycle, 6(16), pp. 1995-2000. (doi:10.4161/cc.6.16.4614)

Crighton, D., Wilkinson, S. and Ryan, K. (2007) DRAM links autophagy to p53 and programmed cell death. Autophagy, 3(1), pp. 72-74.

Crighton, D., O'Prey, J., Bell, H.S. and Ryan, K.M. (2007) p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death and Differentiation, 14(6), pp. 1071-1079. (doi:10.1038/sj.cdd.4402108)

Ewings, K.E. and Ryan, K.M. (2007) Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression. Cell Research, 17(10), pp. 829-831. (doi:10.1038/cr.2007.85)

Bell, L.A., O'Prey, J. and Ryan, K.M. (2006) DNA-binding independent cell death from a minimal proapoptotic region of E2F-1. Oncogene, 25(41), pp. 5656-5663. (doi:10.1038/sj.onc.1209580)

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., Gasco, M., Garrone, O., Crook, T. and Ryan, K. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell, 126(1), pp. 121-134. (doi:10.1016/j.cell.2006.05.034)

Bell, H. and Ryan, K. (2005) Intracellular signalling and cancer: complex pathways lead to multiple targets. European Journal of Cancer, 41(2), pp. 206-215. (doi:10.1016/j.ejca.2004.10.022)

Bell, L. and Ryan, K. (2004) Life and death decisions by E2F-1. Cell Death and Differentiation, 11(2), pp. 137-142. (doi:10.1038/sj.cdd.4401324)

Crighton, D. and Ryan, K.M. (2004) Splicing DNA-damage responses to turnour cell death. Biochimica et Biophysica Acta: Reviews on Cancer, 1705(1), pp. 3-15. (doi:10.1016/j.bbcan.2004.09.001)

Ryan, K. , O'Prey, J. and Vousden, K. (2004) Loss of nuclear factor-KB is tumor promoting but does not substitute for loss of p53. Cancer Research, 64(13), pp. 4415-4418. (doi:10.1158/0008-5472.CAN-04-1474)

Wang, W., Cassidy, J., O'Brien, V., Ryan, K. and Collie-Duguid, E. (2004) Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells. Cancer Research, 64(22), pp. 8167-8176. (doi:10.1158/0008-5472.CAN-04-0970)

Gorgoulis, V.G., Zacharatos, P., Kotsinas, A., Kletsas, D., Mariatos, G., Zoumpourlis, V., Ryan, K.M. , Kittas, C. and Papavassiliou, A.G. (2003) p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO Journal, 22(7), pp. 1567-1578. (doi:10.1093/emboj/cdg157)

Ryan, K. and Vousden, K. (2002) Cancer: Pinning a change on p53. Nature, 419(6909), pp. 795-797. (doi:10.1038/419795a)

Baird, J. et al. (2001) Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. Journal of Biological Chemistry, 276(12), pp. 9189-9198. (doi:10.1074/jbc.M008354200)

Blagosklonny, M., Giannakakou, P., Romanova, L., Ryan, K. , Vousden, K. and Fojo, T. (2001) Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions. Carcinogenesis, 22(6), pp. 861-867. (doi:10.1093/carcin/22.6.861)

Ryan, K. , Phillips, A. and Vousden, K. (2001) Regulation and function of the p53 tumor suppressor protein. Current Opinion in Cell Biology, 13(3), pp. 332-337. (doi:10.1016/S0955-0674(00)00216-7)

This list was generated on Tue Jun 25 19:19:27 2019 BST.