Professor James Norman

  • Professor of Cell Sciences (Beatson Institute for Cancer Research)

Research interests

Rab GTPases that control integrin trafficking are linked to cancer. Our work aims for a full description of the molecular machinery that coordinates integrin traffic during cell migration as these may represent novel targets for anti-metastatic drugs. Integrin trafficking may also guide mRNA to ribosomes associated with the protrusive regions of metastatic cells, and thus localise the synthesis of pro-migratory proteins. A major aim of our research is to characterise the mechanisms by which integrin-associated proteins command mRNA transport and translation during the invasive migration of cancer cells.

Link to Intergrin Cell Biology website


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Evaluation of metabotropic glutamate receptor 3 as a therapeutic target in breast cancer.
    Breast Cancer Now
    2019 - 2022
     
  • The role of the transfer RNA repertoire in dictating secretory phenotypes during epithelial homeostasis
    Medical Research Council
    2017 - 2022
     
  • Glasgow Cancer Centre Clinical Research Fellowship 2016/2017
    Beatson Institute for Cancer Research
    2016 - 2018
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004
Number of items: 54.

2018

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi:10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

2017

Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8(1), 2255. (doi:10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)

Dornier, E. G. and Norman, J. C. (2017) Tensin links energy metabolism to extracellular matrix assembly. Journal of Cell Biology, 216(4), pp. 867-869. (doi:10.1083/jcb.201702025) (PMID:28325807)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi:10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I. , Edwards, J. , Zanivan, S. and Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130(4), pp. 697-711. (doi:10.1242/jcs.190835) (PMID:28062852)

Norman, J. and Zanivan, S. (2017) Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), pp. 1993-1994. (doi:10.1080/15384101.2017.1377031) (PMID:28933594)

2016

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi:10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Boulay, P.-L. et al. (2016) Rab11-FIP1C Is a critical negative regulator in ErbB2-mediated mammary tumor progression. Cancer Research, 76(9), pp. 2662-2674. (doi:10.1158/0008-5472.CAN-15-2782) (PMID:26933086)

2015

Rainero, E. and Norman, J. C. (2015) Endosomal integrin signals for survival. Nature Cell Biology, 17(11), pp. 1373-1375. (doi:10.1038/ncb3261) (PMID:26515017)

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B. , Anderson, K., Critchley, D. R., Machesky, L. and Norman, J. C. (2015) Ligand-occupied integrin internalization links nutrient signaling to invasive migration. Cell Reports, 10(3), pp. 398-413. (doi:10.1016/j.celrep.2014.12.037)

2014

MacPherson, I. R. et al. (2014) CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. Journal of Cell Science, 127(18), pp. 3893-3901. (doi:10.1242/jcs.135947) (PMID:25015290)

Haugsten, E. M., Brech, A., Liestøl, K., Norman, J. C. and Wesche, J. (2014) Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling. Traffic, 15(6), pp. 665-683. (doi:10.1111/tra.12168)

Muller, P. A.J., Trinidad, A. G., Caswell, P. T., Norman, J. C. and Vousden, K. H. (2014) Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. Journal of Biological Chemistry, 289(1), pp. 122-132. (doi:10.1074/jbc.M113.502138)

Macagno, J. P., Diaz Vera, J., Yu, Y., MacPherson, I. , Sandilands, E., Palmer, R., Norman, J. C. , Frame, M. and Vidal, M. (2014) FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genetics, 10(3), e1004262. (doi:10.1371/journal.pgen.1004262)

Rainero, E. et al. (2014) The diacylglycerol kinase α/Atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness. PLoS ONE, 9(6), e97144. (doi:10.1371/journal.pone.0097144) (PMID:24887021) (PMCID:PMC4041662)

2013

Jacquemet, G., Green, D.M., Bridgewater, R.E., von Kriegsheim, A., Humphries, M.J., Norman, J.C. and Caswell, P.T. (2013) RCP-driven 5 1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. Journal of Cell Biology, 202(6), pp. 917-935. (doi:10.1083/jcb.201302041)

Rainero, E. and Norman, J.C. (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. BioEssays, 35(6), pp. 523-532. (doi:10.1002/bies.201200160)

Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi:10.1038/onc.2012.148)

Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. (2013) P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS ONE, 8(1), e53982. (doi:10.1371/journal.pone.0053982) (PMID:23382862) (PMCID:PMC3559689)

2012

Rizzolio, S., Rabinowicz, N., Rainero, E., Lanzetti, L., Serini, G., Norman, J. , Neufeld, G. and Tamagnone, L. (2012) Neuropilin-1-dependent regulation of EGF-receptor signaling. Cancer Research, 72(22), pp. 5801-5811. (doi:10.1158/0008-5472.CAN-12-0995)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi:10.1083/jcb.201203025)

Christoforides, C., Rainero, E., Brown, K.K., Norman, J.C. and Toker, A. (2012) PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Developmental Cell, 23(3), pp. 560-572. (doi:10.1016/j.devcel.2012.08.008)

Chen, Y. et al. (2012) Aquaporin 2 promotes cell migration and epithelial morphogenesis. Journal of the American Society of Nephrology, 23(9), pp. 1506-1517. (doi:10.1681/ASN.2012010079)

Bridgewater, R.E., Norman, J.C. and Caswell, P.T. (2012) Integrin trafficking at a glance. Journal of Cell Science, 125(16), pp. 3695-3701. (doi:10.1242/jcs.095810)

Eva, R., Crisp, S., Marland, J.R.K., Norman, J.C. , Kanamarlapudi, V., ffrench-Constant, C. and Fawcett, J.W. (2012) ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons. Journal of Neuroscience, 32(30), pp. 10352-10364.

von Thun, A., Birtwistle, M., Kalna, G., Grindlay, J., Strachan, D., Kolch, W., von Kriegsheim, A. and Norman, J.C. (2012) ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. Journal of Cell Science, 125(6), pp. 1465-1477. (doi:10.1242/jcs.092916)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi:10.1016/j.devcel.2011.11.008)

Margadant, C., Kreft, M., de Groot, D., Norman, J.C. and Sonnenberg, A. (2012) Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking. Current Biology, 22(17), pp. 1554-1563. (doi:10.1016/j.cub.2012.06.060)

Rainero, E., Caswell, P.T., Muller, P.A.J., Grindlay, J., McCaffrey, M.W., Zhang, Q., Wakelam, M.J.O., Vousden, K.H., Graziani, A. and Norman, J.C. (2012) Diacylglycerol kinase controls RCP-dependent integrin trafficking to promote invasive migration. Journal of Cell Biology, 196(2), pp. 277-295. (doi:10.1083/jcb.201109112)

2011

Margadant, C., Monsuur, H.N., Norman, J.C. and Sonnenberg, A. (2011) Mechanisms of integrin activation and trafficking. Current Opinion in Cell Biology, 23(5), pp. 607-614. (doi:10.1016/j.ceb.2011.08.005)

Muller, P.A.J., Vousden, K. and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192(2), pp. 209-218. (doi:10.1083/jcb.201009059)

Rainero, E. and Norman, J.C. (2011) New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing. Science Signaling, 4(171), pe24. (doi:10.1126/scisignal.2002053)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H. , Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi:10.1242/jcs.080986)

2010

Di Blasio, L., Droetto, S., Norman, J. , Bussolino, F. and Primo, L. (2010) Protein Kinase D1 Regulates VEGF-A-Induced αvβ3 Integrin Trafficking and Endothelial Cell Migration. Traffic, 11(8), pp. 1107-1118. (doi:10.1111/j.1600-0854.2010.01077.x)

Eva, R., Dassie, E., Caswell, P.T., Dick, G., ffrench-Constant, C., Norman, J.C. and Fawcett, J.W. (2010) Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of beta 1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells. Journal of Neuroscience, 30(35), pp. 11654-11669. (doi:10.1523/JNEUROSCI.2425-10.2010)

2009

Caswell, P.T., Vadrevu, S. and Norman, J.C. (2009) Integrins: masters and slaves of endocytic transport. Nature Reviews Molecular Cell Biology, 10(12), pp. 843-853. (doi:10.1038/nrm2799)

Jones, M.C., Caswell, P.T., Moran-Jones, K., Roberts, M., Barry, S.T., Gampel, A., Mellor, H. and Norman, J.C. (2009) VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching. Traffic, 10(6), pp. 754-766. (doi:10.1111/j.1600-0854.2009.00898.x)

Kelly, E.E., Horgan, C.P., Adams, C., Patzer, T.M., Ní Shúilleabháin, D.M., Norman, J.C. and McCaffrey, M.W. (2009) Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. Biology of the Cell, 102(1), pp. 51-62. (doi:10.1042/BC20090068)

Mills, G.B., Jurisica, I., Yarden, Y. and Norman, J.C. (2009) Genomic amplicons target vesicle recycling in breast cancer. Journal of Clinical Investigation, 119(8), pp. 2123-2127. (doi:10.1172/JCI40256)

Moran-Jones, K., Grindlay, J., Jones, M., Smith, R. and Norman, J.C. (2009) hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration. Cancer Research, 69(24), pp. 9219-9227. (doi:10.1158/0008-5472.CAN-09-1852)

Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi:10.1016/j.cell.2009.11.026)

Reynolds, A.R. et al. (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15(4), pp. 392-400. (doi:10.1038/nm.1941)

Valdembri, D. et al. (2009) Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells. PLoS Biology, 7(1), e1000025. (doi:10.1371/journal.pbio.1000025)

2008

Caswell, P. and Norman, J. (2008) Endocytic transport of integrins during cell migration and invasion. Trends in Cell Biology, 18(6), pp. 257-263. (doi:10.1016/j.tcb.2008.03.004)

Caswell, P.T., Chan, M., Lindsay, A.J., McCaffrey, M.W., Boettiger, D. and Norman, J.C. (2008) Rab-coupling protein coordinates recycling of  5 1 integrin and EGFR1 to promote cell migration in 3D microenvironments. Journal of Cell Biology, 183(1), pp. 143-155. (doi:10.1083/jcb.200804140)

Frame, M. and Norman, J. (2008) A tal(in) of cell spreading. Nature Cell Biology, 10(9), pp. 1017-1019. (doi:10.1038/ncb0908-1017)

2007

Caswell, P. et al. (2007) Rab25 associates with alpha 5 beta 1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell, 13(4), pp. 496-510. (doi:10.1016/j.devcel.2007.08.012)

Kim, M. et al. (2007) Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis, 29(3), pp. 629-637. (doi:10.1093/carcin/bgm291)

Muddasani, P., Norman, J. , Ellman, M., van Wijnen, A. and Im, H. (2007) Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. Journal of Biological Chemistry, 282(43), pp. 31409-31421. (doi:10.1074/jbc.M706508200)

White, D., Caswell, P. and Norman, J. (2007) alpha V beta 3 and alpha 5B1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. Journal of Cell Biology, 177(3), pp. 515-525. (doi:10.1083/jcb.200609004)

2006

Caswell, P. and Norman, J. (2006) Integrin trafficking and the control of cell migration. Traffic, 7, pp. 14-21. (doi:10.1111/j.1600-0854.2005.00362.x)

Gampel, A., Moss, L., Jones, M., Brunton, V., Norman, J. and Mellor, H. (2006) VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood, 108, pp. 2624-2631. (doi:10.1182/blood-2005-12-007484)

Jones, M., Caswell, T. and Norman, J. (2006) Endocytic recycling pathways: emerging regulators of cell migration. Current Opinion in Cell Biology, 18(5), pp. 549-557. (doi:10.1016/j.ceb.2006.08.003)

2004

Sandilands, E., Cans, C., Fincham, V., Brunton, V., Mellor, H., Prendergast, G., Norman, J. , Superti-Furga, G. and Frame, M. (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Developmental Cell, 7(6), pp. 855-869. (doi:10.1016/j.devcel.2004.09.019)

This list was generated on Sat Jul 20 07:19:49 2019 BST.
Jump to: Articles
Number of items: 54.

Articles

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi:10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8(1), 2255. (doi:10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)

Dornier, E. G. and Norman, J. C. (2017) Tensin links energy metabolism to extracellular matrix assembly. Journal of Cell Biology, 216(4), pp. 867-869. (doi:10.1083/jcb.201702025) (PMID:28325807)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi:10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Diaz-Vera, J., Palmer, S., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., MacPherson, I. , Edwards, J. , Zanivan, S. and Norman, J. C. (2017) A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. Journal of Cell Science, 130(4), pp. 697-711. (doi:10.1242/jcs.190835) (PMID:28062852)

Norman, J. and Zanivan, S. (2017) Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), pp. 1993-1994. (doi:10.1080/15384101.2017.1377031) (PMID:28933594)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi:10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Boulay, P.-L. et al. (2016) Rab11-FIP1C Is a critical negative regulator in ErbB2-mediated mammary tumor progression. Cancer Research, 76(9), pp. 2662-2674. (doi:10.1158/0008-5472.CAN-15-2782) (PMID:26933086)

Rainero, E. and Norman, J. C. (2015) Endosomal integrin signals for survival. Nature Cell Biology, 17(11), pp. 1373-1375. (doi:10.1038/ncb3261) (PMID:26515017)

Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B. , Anderson, K., Critchley, D. R., Machesky, L. and Norman, J. C. (2015) Ligand-occupied integrin internalization links nutrient signaling to invasive migration. Cell Reports, 10(3), pp. 398-413. (doi:10.1016/j.celrep.2014.12.037)

MacPherson, I. R. et al. (2014) CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. Journal of Cell Science, 127(18), pp. 3893-3901. (doi:10.1242/jcs.135947) (PMID:25015290)

Haugsten, E. M., Brech, A., Liestøl, K., Norman, J. C. and Wesche, J. (2014) Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling. Traffic, 15(6), pp. 665-683. (doi:10.1111/tra.12168)

Muller, P. A.J., Trinidad, A. G., Caswell, P. T., Norman, J. C. and Vousden, K. H. (2014) Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. Journal of Biological Chemistry, 289(1), pp. 122-132. (doi:10.1074/jbc.M113.502138)

Macagno, J. P., Diaz Vera, J., Yu, Y., MacPherson, I. , Sandilands, E., Palmer, R., Norman, J. C. , Frame, M. and Vidal, M. (2014) FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genetics, 10(3), e1004262. (doi:10.1371/journal.pgen.1004262)

Rainero, E. et al. (2014) The diacylglycerol kinase α/Atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness. PLoS ONE, 9(6), e97144. (doi:10.1371/journal.pone.0097144) (PMID:24887021) (PMCID:PMC4041662)

Jacquemet, G., Green, D.M., Bridgewater, R.E., von Kriegsheim, A., Humphries, M.J., Norman, J.C. and Caswell, P.T. (2013) RCP-driven 5 1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. Journal of Cell Biology, 202(6), pp. 917-935. (doi:10.1083/jcb.201302041)

Rainero, E. and Norman, J.C. (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. BioEssays, 35(6), pp. 523-532. (doi:10.1002/bies.201200160)

Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi:10.1038/onc.2012.148)

Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. (2013) P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS ONE, 8(1), e53982. (doi:10.1371/journal.pone.0053982) (PMID:23382862) (PMCID:PMC3559689)

Rizzolio, S., Rabinowicz, N., Rainero, E., Lanzetti, L., Serini, G., Norman, J. , Neufeld, G. and Tamagnone, L. (2012) Neuropilin-1-dependent regulation of EGF-receptor signaling. Cancer Research, 72(22), pp. 5801-5811. (doi:10.1158/0008-5472.CAN-12-0995)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi:10.1083/jcb.201203025)

Christoforides, C., Rainero, E., Brown, K.K., Norman, J.C. and Toker, A. (2012) PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Developmental Cell, 23(3), pp. 560-572. (doi:10.1016/j.devcel.2012.08.008)

Chen, Y. et al. (2012) Aquaporin 2 promotes cell migration and epithelial morphogenesis. Journal of the American Society of Nephrology, 23(9), pp. 1506-1517. (doi:10.1681/ASN.2012010079)

Bridgewater, R.E., Norman, J.C. and Caswell, P.T. (2012) Integrin trafficking at a glance. Journal of Cell Science, 125(16), pp. 3695-3701. (doi:10.1242/jcs.095810)

Eva, R., Crisp, S., Marland, J.R.K., Norman, J.C. , Kanamarlapudi, V., ffrench-Constant, C. and Fawcett, J.W. (2012) ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons. Journal of Neuroscience, 32(30), pp. 10352-10364.

von Thun, A., Birtwistle, M., Kalna, G., Grindlay, J., Strachan, D., Kolch, W., von Kriegsheim, A. and Norman, J.C. (2012) ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. Journal of Cell Science, 125(6), pp. 1465-1477. (doi:10.1242/jcs.092916)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi:10.1016/j.devcel.2011.11.008)

Margadant, C., Kreft, M., de Groot, D., Norman, J.C. and Sonnenberg, A. (2012) Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking. Current Biology, 22(17), pp. 1554-1563. (doi:10.1016/j.cub.2012.06.060)

Rainero, E., Caswell, P.T., Muller, P.A.J., Grindlay, J., McCaffrey, M.W., Zhang, Q., Wakelam, M.J.O., Vousden, K.H., Graziani, A. and Norman, J.C. (2012) Diacylglycerol kinase controls RCP-dependent integrin trafficking to promote invasive migration. Journal of Cell Biology, 196(2), pp. 277-295. (doi:10.1083/jcb.201109112)

Margadant, C., Monsuur, H.N., Norman, J.C. and Sonnenberg, A. (2011) Mechanisms of integrin activation and trafficking. Current Opinion in Cell Biology, 23(5), pp. 607-614. (doi:10.1016/j.ceb.2011.08.005)

Muller, P.A.J., Vousden, K. and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192(2), pp. 209-218. (doi:10.1083/jcb.201009059)

Rainero, E. and Norman, J.C. (2011) New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing. Science Signaling, 4(171), pe24. (doi:10.1126/scisignal.2002053)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H. , Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi:10.1242/jcs.080986)

Di Blasio, L., Droetto, S., Norman, J. , Bussolino, F. and Primo, L. (2010) Protein Kinase D1 Regulates VEGF-A-Induced αvβ3 Integrin Trafficking and Endothelial Cell Migration. Traffic, 11(8), pp. 1107-1118. (doi:10.1111/j.1600-0854.2010.01077.x)

Eva, R., Dassie, E., Caswell, P.T., Dick, G., ffrench-Constant, C., Norman, J.C. and Fawcett, J.W. (2010) Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of beta 1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells. Journal of Neuroscience, 30(35), pp. 11654-11669. (doi:10.1523/JNEUROSCI.2425-10.2010)

Caswell, P.T., Vadrevu, S. and Norman, J.C. (2009) Integrins: masters and slaves of endocytic transport. Nature Reviews Molecular Cell Biology, 10(12), pp. 843-853. (doi:10.1038/nrm2799)

Jones, M.C., Caswell, P.T., Moran-Jones, K., Roberts, M., Barry, S.T., Gampel, A., Mellor, H. and Norman, J.C. (2009) VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching. Traffic, 10(6), pp. 754-766. (doi:10.1111/j.1600-0854.2009.00898.x)

Kelly, E.E., Horgan, C.P., Adams, C., Patzer, T.M., Ní Shúilleabháin, D.M., Norman, J.C. and McCaffrey, M.W. (2009) Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. Biology of the Cell, 102(1), pp. 51-62. (doi:10.1042/BC20090068)

Mills, G.B., Jurisica, I., Yarden, Y. and Norman, J.C. (2009) Genomic amplicons target vesicle recycling in breast cancer. Journal of Clinical Investigation, 119(8), pp. 2123-2127. (doi:10.1172/JCI40256)

Moran-Jones, K., Grindlay, J., Jones, M., Smith, R. and Norman, J.C. (2009) hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration. Cancer Research, 69(24), pp. 9219-9227. (doi:10.1158/0008-5472.CAN-09-1852)

Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi:10.1016/j.cell.2009.11.026)

Reynolds, A.R. et al. (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15(4), pp. 392-400. (doi:10.1038/nm.1941)

Valdembri, D. et al. (2009) Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells. PLoS Biology, 7(1), e1000025. (doi:10.1371/journal.pbio.1000025)

Caswell, P. and Norman, J. (2008) Endocytic transport of integrins during cell migration and invasion. Trends in Cell Biology, 18(6), pp. 257-263. (doi:10.1016/j.tcb.2008.03.004)

Caswell, P.T., Chan, M., Lindsay, A.J., McCaffrey, M.W., Boettiger, D. and Norman, J.C. (2008) Rab-coupling protein coordinates recycling of  5 1 integrin and EGFR1 to promote cell migration in 3D microenvironments. Journal of Cell Biology, 183(1), pp. 143-155. (doi:10.1083/jcb.200804140)

Frame, M. and Norman, J. (2008) A tal(in) of cell spreading. Nature Cell Biology, 10(9), pp. 1017-1019. (doi:10.1038/ncb0908-1017)

Caswell, P. et al. (2007) Rab25 associates with alpha 5 beta 1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell, 13(4), pp. 496-510. (doi:10.1016/j.devcel.2007.08.012)

Kim, M. et al. (2007) Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis, 29(3), pp. 629-637. (doi:10.1093/carcin/bgm291)

Muddasani, P., Norman, J. , Ellman, M., van Wijnen, A. and Im, H. (2007) Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. Journal of Biological Chemistry, 282(43), pp. 31409-31421. (doi:10.1074/jbc.M706508200)

White, D., Caswell, P. and Norman, J. (2007) alpha V beta 3 and alpha 5B1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. Journal of Cell Biology, 177(3), pp. 515-525. (doi:10.1083/jcb.200609004)

Caswell, P. and Norman, J. (2006) Integrin trafficking and the control of cell migration. Traffic, 7, pp. 14-21. (doi:10.1111/j.1600-0854.2005.00362.x)

Gampel, A., Moss, L., Jones, M., Brunton, V., Norman, J. and Mellor, H. (2006) VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood, 108, pp. 2624-2631. (doi:10.1182/blood-2005-12-007484)

Jones, M., Caswell, T. and Norman, J. (2006) Endocytic recycling pathways: emerging regulators of cell migration. Current Opinion in Cell Biology, 18(5), pp. 549-557. (doi:10.1016/j.ceb.2006.08.003)

Sandilands, E., Cans, C., Fincham, V., Brunton, V., Mellor, H., Prendergast, G., Norman, J. , Superti-Furga, G. and Frame, M. (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Developmental Cell, 7(6), pp. 855-869. (doi:10.1016/j.devcel.2004.09.019)

This list was generated on Sat Jul 20 07:19:49 2019 BST.