Dr Rucha Karnik

  • Royal Society University Research Fellow (Institute of Molecular Cell and Systems Biology)

telephone: 01413301945
email: Rucha.Karnik@glasgow.ac.uk

Biography

I obtained my Bachelor’s degree in Biochemistry (St Xavier’s College, Ahmedabad) and Masters in Biotechnology from the Gujarat University in India, earned with a 1st rank in the Masters programme. I then spent over six years in the pharma-biotech industry where I worked on research, marketing and management aspects of various projects including development of recombinant protein-based diagnostic kits, human therapeutics, biosimilars and the agro-biotech business. Drawn to fundamental research in human disease, I left the industry and moved to the UK to pursue my PhD at the University of Leeds, in the Institute of Membrane and Systems Biology. I was awarded fellowships from the prestigious Overseas Research Students Awards Scheme (ORSAS) sponsored by the British government, the Tetley & Lupton Scholarship and the International Research Scholarship from the University of Leeds for my PhD. At Leeds, I investigated membrane traffic of human K+ channels and its implications for health and disease. For my postdoc, I joined Mike Blatt’s group at the University of Glasgow (2011) where I started working with plants. I have since pursued closely related themes of membrane transport, regulation of membrane traffic and cellular homeostasis, developing a fundamental interest in molecular mechanisms of vesicle traffic and its coordination with transport, which are critical for plant physiology.  As a Royal Society University Research Fellow, the University of Glasgow continues to be my home. To achieve food security in the face of global environment change, it is essential that we improve agricultural crops for efficient growth, nutrient uptake, CO2 and water utilisation and responses to biotic stresses. Therefore, research directed to understanding, predicting, and manipulating the molecular mechanisms of plant growth and responses to the environment is at the forefront of scientific interest. My research focus centres around understainding the role of hormone regulated membrane traffic in plant growth and homeostasis.

Outreach:

Book concept, design and editing for Plant Scientists ‘Glimpses into the Minds’ , a unique book with doodle art from Dr Mathis Riehle showcasing research interests of the Plant Science Group.

Available for download at: https://docs.wixstatic.com/ugd/8cabfa_bcc30b9859b347e294d6ffe6c924205b.pdf [22mb PDF]

For paper copy, please contact me.

Research interests

Technical staffLab staffUG studentsPhD studentsLab alumni
Mr Craig Bruce Dr Maria Del Mar Marques-Beuno

Elka Kyurkchieva

MVLS Summer Studentship

Lab intern 2017-18

Hayleigh Hunter

Royal Society funded PhD Student

David Gibbs-Smith

MSc Biomedical Science

  Ms Swati Patil

Matthew Habasque

Honours Student 2017-18

Lingfeng Xia

China Scholarship Council (CSC) & University of Glasgow funded PhD Student

 

 

 

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Proton Transport Modulators - Spatial Regulation and Effects on Plant Physiology
    Royal Society
    2017 - 2021
     
  • Hormone-Regulated Membrane Traffic and Plant Morphogenesis
    Royal Society
    2016 - 2021
     

Publications

List by: Type | Date

Jump to: 2017 | 2015 | 2014 | 2013 | 2012
Number of items: 9.

2017

Karnik, R., Waghmare, S., Zhang, B. , Larson, E., Lefoulon, C., Gonzalez, W. and Blatt, M. R. (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22(1), pp. 81-95. (doi:10.1016/j.tplants.2016.10.006) (PMID:27818003) (PMCID:PMC5224186)

Zhang, B. , Karnik, R., Waghmare, S., Donald, N. A. and Blatt, M. R. (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173(1), pp. 536-551. (doi:10.1104/pp.16.01549) (PMID:27821719)

2015

Grefen, C., Karnik, R., Larson, E., Lefoulon, C., Wang, Y., Waghmare, S., Zhang, B. , Hills, A. and Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, 15108. (doi:10.1038/nplants.2015.108)

Zhang, B. , Karnik, R., Wang, Y., Wallmeroth, N., Blatt, M. R. and Grefen, C. (2015) The arabidopsis R-SNARE VAMP721 interacts with KAT1 and KC1 K+ channels to moderate K+ current at the plasma membrane. Plant Cell, 27(6), pp. 1697-1717. (doi:10.1105/tpc.15.00305) (PMID:26002867) (PMCID:PMC4498211)

Karnik, R., Zhang, B. , Waghmare, S., Aderhold, C., Grefen, C. and Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27(3), pp. 675-694. (doi:10.1105/tpc.114.134429) (PMID:25747882)

2014

Lefoulon, C., Karnik, R., Honsbein, A., Gutla, P. V., Grefen, C., Riedelsberger, J., Poblete, T., Dreyer, I., Gonzalez, W. and Blatt, M. R. (2014) Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor. Plant Physiology, 166(2), pp. 960-975. (doi:10.1104/pp.114.244319) (PMID:25185120)

2013

Karnik, R., Grefen, C., Bayne, R., Honsbein, A., Kohler, T., Kioumourtzoglou, D., Williams, M., Bryant, N.J. and Blatt, M.R. (2013) Arabidopsis Sec1/Munc18 protein SEC11 is a competitive and dynamic modulator of SNARE binding and SYP121-dependent vesicle traffic. Plant Cell, 25(4), pp. 1368-1382. (doi:10.1105/tpc.112.108506)

Karnik, A., Karnik, R. and Grefen, C. (2013) SDM-Assist software to design site-directed mutagenesis primers introducing “silent” restriction sites. BMC Bioinformatics, 14, 105. (doi:10.1186/1471-2105-14-105) (PMID:23522286) (PMCID:PMC3644487)

2012

Wang, Y., Papanatsiou, M., Eisenach, C., Karnik, R., Williams, M., Hills, A., Lew, V.L. and Blatt, M.R. (2012) Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration. Plant Physiology, 160(4), pp. 1956-1967. (doi:10.1104/pp.112.207704)

This list was generated on Sat Oct 21 15:35:51 2017 BST.
Jump to: Articles
Number of items: 9.

Articles

Karnik, R., Waghmare, S., Zhang, B. , Larson, E., Lefoulon, C., Gonzalez, W. and Blatt, M. R. (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22(1), pp. 81-95. (doi:10.1016/j.tplants.2016.10.006) (PMID:27818003) (PMCID:PMC5224186)

Zhang, B. , Karnik, R., Waghmare, S., Donald, N. A. and Blatt, M. R. (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173(1), pp. 536-551. (doi:10.1104/pp.16.01549) (PMID:27821719)

Grefen, C., Karnik, R., Larson, E., Lefoulon, C., Wang, Y., Waghmare, S., Zhang, B. , Hills, A. and Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, 15108. (doi:10.1038/nplants.2015.108)

Zhang, B. , Karnik, R., Wang, Y., Wallmeroth, N., Blatt, M. R. and Grefen, C. (2015) The arabidopsis R-SNARE VAMP721 interacts with KAT1 and KC1 K+ channels to moderate K+ current at the plasma membrane. Plant Cell, 27(6), pp. 1697-1717. (doi:10.1105/tpc.15.00305) (PMID:26002867) (PMCID:PMC4498211)

Karnik, R., Zhang, B. , Waghmare, S., Aderhold, C., Grefen, C. and Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27(3), pp. 675-694. (doi:10.1105/tpc.114.134429) (PMID:25747882)

Lefoulon, C., Karnik, R., Honsbein, A., Gutla, P. V., Grefen, C., Riedelsberger, J., Poblete, T., Dreyer, I., Gonzalez, W. and Blatt, M. R. (2014) Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor. Plant Physiology, 166(2), pp. 960-975. (doi:10.1104/pp.114.244319) (PMID:25185120)

Karnik, R., Grefen, C., Bayne, R., Honsbein, A., Kohler, T., Kioumourtzoglou, D., Williams, M., Bryant, N.J. and Blatt, M.R. (2013) Arabidopsis Sec1/Munc18 protein SEC11 is a competitive and dynamic modulator of SNARE binding and SYP121-dependent vesicle traffic. Plant Cell, 25(4), pp. 1368-1382. (doi:10.1105/tpc.112.108506)

Karnik, A., Karnik, R. and Grefen, C. (2013) SDM-Assist software to design site-directed mutagenesis primers introducing “silent” restriction sites. BMC Bioinformatics, 14, 105. (doi:10.1186/1471-2105-14-105) (PMID:23522286) (PMCID:PMC3644487)

Wang, Y., Papanatsiou, M., Eisenach, C., Karnik, R., Williams, M., Hills, A., Lew, V.L. and Blatt, M.R. (2012) Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration. Plant Physiology, 160(4), pp. 1956-1967. (doi:10.1104/pp.112.207704)

This list was generated on Sat Oct 21 15:35:51 2017 BST.