TransSCOT is the translational arm of the SCOT trial, an “international, randomised, phase 3, non-inferiority trial” involving adult patients with high-risk stage II or stage III colorectal cancer.

The TransSCOT project aims to support collaborators with CRC research.  We will do this by: 

  • Managing a large tissue bank of tumour resections and matched normal FFPE blocks from over 3,000 patients from the SCOT trial.
  • Managing a large blood bank of the same patients (serum and EDTA)
  • constructing a biobank of tissue microarrays containing tumour centre and invasive edge from the SCOT tissue blocks for use in future projects
  • Extracting DNA and RNA for sequencing and future projects
  • building a large bank of digital images for data sharing
  • building a comprehensive database of anonymised information for data mining projects, including, but not limited to: anonymised linked clinical data, anonymised pathology data, anonymised genomic and transcriptomics data, shared outputs and results from collaborators to build upon existing research.