We are a collective of researchers at the University of Glasgow who use Drosophila melanogaster. We work in areas including development, cancer, physiology, ageing, metabolism and food security.
Many genes and processes are eveloutionarily conserved: in diverse organisms we find the same genes doing the same things in the same tissues, even after millions of years of evloutionary divergence. This means that undertaking the function of a conserved gene in one organism often gives us a good idea of its function in another organism.
We pursue that understanding in Drosophila. We can manipulate genetics very efficiently and effectively, for example by precisely altering expressions of a specific gene, or tagging a protein to see where it localises, or by deleting parts of the genome. We can then rapidly test effects on outputs like behaviour, survival or tumour formation.
In Glasgow, we use this approach to manipulate and understand processes and functions including ageing, tissue-tissue communication and kidney function, with implications for human disease and bioindistry, as well as understanding biological function.
About Cagan Group
Dow & Davies Group
About Dow & Davies Group
Nutritional systems biology: we are interested in optimising microbiota and diet to promote lifelong health.
About O'Dell Group
Our laboratory is understanding how mitochondria contribute to the ageing process and the onset of age-related diseases. We aim to develop new therapies to help people live healthier for longer.