Professor Shireen Davies

  • Professor of Integrative Cell Signalling (Institute of Molecular Cell and Systems Biology)
  • Associate Academic (Institute of Biodiversity Animal Health and Comparative Medicine)

telephone: 01413302317
email: Shireen.Davies@glasgow.ac.uk

Biography

Shireen was born in Singapore and attended Convent of the Holy Infant Jesus, Singapore and Westonbirt School, England. After leaving school, she studied at the Univeristy of Aberdeen, gaining BSc (Hons), Biochemistry 1st Class, University of Aberdeen. She then went on to gain her PhD in Biochemistry at the University of Glasgow.

Awards
University of Glasgow Faculty of Medicine Scholarship and Overseas Student Research Award

Post-doctoral career
1989-1990: Department of Biochemistry, University of Glasgow
1990-1993: Career break
1993-1996: Departments of Cell Biology and Genetics, University of Glasgow
1995: Journal of Cell Science Travel Fellow, Institute of Neuroscience, University of Oregon, USA
1996-2001: BBSRC David Phillips Fellow, Department of Genetics, University of Glasgow
2002-2005: Senior Lecturer, Division of Molecular Genetics, Institute of Biomedical and Life Sciences,
University of Glasgow
2005-2009: Reader, Integrative and Systems Biology, Integrated Biology Division, Faculty of Biomedical
and Life Sciences, University of Glasgow
2009-current: Professor of Integrative Cell Signalling, University of Glasgow
2015: Visiting Professor, Department of Molecular Medicine, Faculty of Medicine, University of Malaya

Research interests

I am interested in how organisms tolerate and survive environmental stress, and so use the model insect Drosophila melanogaster to understand this process from the molecular level to whole organisms and species. In particular, we seek to understand the key roles of peptide hormones (neuropeptides), which act on epithelial cells and tissues in stress survival. We utilise approaches including molecular and cellular biology, physiology, peptide analogues and the ‘omic' technologies (genomics, transcriptomics, metabolomics). Using these approaches in Drosophila, we can address fundamental questions of mechanisms of stress tolerance in vivo, which can also be applied to biomedicine (e.g. metabolic, oxidative stress, renal development). We can also increase understanding of insect physiology, and are working on novel insecticide targets for Food Security (insect pests of agriculture, horticulture and forestry), and for Human and Animal Health (insect vectors of disease) by working on pest insect species and by developing novel assays/screens.

Our research is supported by the Biotechnology and Biological Sciences Research Council (BBSRC); the European Union's Horizon 2020 funding programme - nEUROSTRESSPEP (Coordinator) and RenalTract; and by industry and other organisations.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • ISCF Agri-Food Technology Catalyst Seeding Catalyst Award
    Biotechnology and Biological Sciences Research Council
    2017 - 2018
     
  • FlyMet.org - a tissue-based metabolomic online resource for the Drosophila and systems biology communities
    Biotechnology and Biological Sciences Research Council
    2017 - 2020
     
  • Functional analysis of insect neuropeptide G protein-coupled receptors
    Biotechnology and Biological Sciences Research Council
    2017 - 2020
     
  • nEUROSTRESSPEP
    European Commission
    2015 - 2019
     
  • RENALTRACT
    European Commission
    2015 - 2019
     
  • New approaches for insect control for Food Security
    Biotechnology and Biological Sciences Research Council
    2014 - 2016
     
  • Identifying new leads for a major medical problem, using a unique in vivo model for kidney stones - Sparking Impact Award
    Biotechnology and Biological Sciences Research Council
    2014 - 2014
     
  • FlyAtlas2: a definitive, expanded NGS expression resource for the Drosophila community and beyond.
    Biotechnology and Biological Sciences Research Council
    2013 - 2017
     
  • Functional Genomics of the enigmatic stellate cell.
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Japan-Systems Approaches to Addressing Food Security: Novel methodology for pest control using key regulators of insect survival against infection
    Biotechnology and Biological Sciences Research Council
    2012 - 2015
     
  • A new direction for insect control: transporters as novel targets for insecticidal compunds.
    Scottish Universities Life Sciences Alliance
    2012 - 2012
     
  • Extraordinary pH - the mechanism of generation of pH 12 in living systems
    Biotechnology and Biological Sciences Research Council
    2012 - 2014
     
  • Unravelling the function of the Nha gene family
    BBSRC
    2009 - 2012
     
  • Epithelial stress sensors: novel roles for cytochrome P450s and organellar calcium in integrated stress and immune responses.
    BBSRC
    2009 - 2013
     
  • Genetic, proteomic and functional analysis of junctional complexes in Drosophila
    BBSRC
    2008 - 2011
     
  • Cyclic nucleotide signalling in innate immunity
    BBSRC
    2007 - 2010
     
  • Spatiotemporal filtering in calcium control of mitochondrial function
    BBSRC
    2006 - 2009
     
  • Investigation of calcium signalling in sarcoplasmic riticulum of cardiac myocytes using a novel targeted reporter
    BBSRC
    2005 - 2008
     
  • Exploration of cyclic 3', 5' guanosine monophosphate (cGMP) signalling dynamics in vivo
    BBSRC
    2004 - 2008
     
  • Confocal laser scanning microscope
    BBSRC
    2003 - 2006
     
  • Function of intracellular calcium pools in renal transport - unravelling complexities using targeted calcium reporters
    BBSRC
    2003 - 2006
     
  • Comparative integrative physiology of novel branches of the NA+/H+ exchanger family
    BBSRC
    2003 - 2006
     

Teaching

•    Deputy Coordinator, Masters in Food Security
•    Level 4 Biochemistry Central Approaches in Biochemistry Option

Additional information

Grant Advisory Board

  • 2016 - ongoing: BBSRC - Core Panel Member Committee E - Fellowships and personal awards
  • 2015 - ongoing: FWO (Research Foundation - Flanders) - Core Panel Member - Bio2 Grants and Fellowships Panel
  • 2010 - 2014: BBSRC - Core Panel Member Committee D - Molecules, Cells and Industrial Biotechnology

Invited International Presentations

  • 2015: Myanmar - Invertebrate Neuropeptide Conference
  • 2015: Kuala Lumpur, Malaysia - University of Malaya
  • 2015: Brussels, Belgium - European Commission
  • 2015: Sendai, Japan - Organiser, 2nd Young Researchers Conference, Tohoku University, BBSRC
  • 2015: Research Triangle Park, North Carolina, USA - Industry
  • 2014: Rennes, France - Conference of European Comparative Endocrinologists, State of the Art Lecture
  • 2014: Kuala Lumpur, Malaysia - University of Malaya
  • 2014: Glasgow, Scotland, UK - Organiser, International conference, "The Epitheliome: potential new targets for insecticides?", BBSRC and Japan Science and Technology Agency
  • 2013: Barcelona, Spain - State of the Art Lecture, Homeostasis Symposium, International Conference of Comparative Endocrinology
  • 2013: Switzerland - Stress: challenging homeostasis, Journal of Experimental Biology
  • 2013: Thailand - Invertebrate Neuropeptide Conference
  • 2013: Oxford, England, UK - University of Oxford
  • 2013: Sendai, Japan - Organiser, Young Researchers’ Conference, Tohoku University, BBSRC
  • 2013: Switzerland - Organiser, International conference, 'Stress: challenging homeostasis', Company of Biologists and Journal of Experimental Biology
  • 2012: Zurich, Switzerland - Conference of European Comparative Endocrinologists
  • 2012: Sendai, Japan - Graduate School of Pharmaceutical Sciences, Tohoku University
  • 2012: Glasgow, Scotland, UK - Festschrift, Professor Miles Houslay
  • 2011: Paisley, Scotland, UK - Scottish Funding Council Equality Conference
  • 2011: Glasgow, Scotland, UK - Society for Experimental Biology International Meeting
  • 2011: East Malaysia - Invertebrate Neuropeptide Conference
  • 2011: Glasgow, Scotland, UK - Scottish Vitae Young Researchers Network Conference, University of Glasgow
  • 2010: Pecs, Hungary - Conference of European Comparative Endocrinologists, State of the Art Lecture
  • 2010: Glasgow, Scotland, UK - Wellcome Centre for Molecular Parasitology, University of Glasgow
  • 2010: London, England, UK - Leadership Conference, Imperial College
  • 2008: Deidesheim, Germany - BASF Symposium
  • 2008: Marseille, France - Society for Experimental Biology International Meeting
  • 2006: Maine, USA - Invited seminar speaker at Gordon Conference on Phosphodiesterases
  • 2006: Cambridge, England, UK - Invited seminar and participant in Biochemical Society meeting on cAMP compartmentalization
  • 2006: San Diego, California, USA - Invited seminar speaker at the American Society of Nephrology meeting
  • 2005: Barcelona, Spain - Co-organiser of the Insect Physiology symposium, Society for Experimental Biology International Meeting

Research Fellowship

  • 1996 - 2001: BBSRC Advanced Fellowship

Supervision

    2004
    Industry, (co-I). January 2004-2007
    BBSRC Committee Studentship (co-I), October 2004-2007 (Guanylate cyclases in Drosophila)
    BBSRC, October 2004-2008, (Exploration of cyclic nucleotide guanosine 3’, 5’- cyclic monophosphate
    (cGMP) signalling dynamics in vivo)


    2005
    BBSRC, January 2005-2008, £330k (Investigation of calcium signalling in sarcoplasmic reticulum of cardiac myocytes using a novel targeted reporter)


    2006
    BBSRC Committee Studentship, January 2006-2009 (Phosphodiesterases and cGMP homeostasis in Drosophila renal transport)
    BBSRC grant, (co-I) June 2006-2009 (Spatiotemporal filtering in calcium control of mitochondrial function)


    2007
    BBSRC, January 2007-2010 (Cyclic nucleotide modulation of innate immunity)
    Industry, (co-I). January 2007-2008.


    2008
    BBSRC grant (co-I) July 2008-2011 (Proteomic analysis of junctional complexes in Drosophila)
    Industry, (co-I). August 2008-2009
    Industry, (co-I). 2008-2010


    2009
    BBSRC June 2009-2013 (Epithelial stress sensors: novel roles for cytochrome P450s and organellar calcium in integrated stress and immune responses)


    2010
    BBSRC (co-I) March 2010-2013 (Industrial Partnership Award: Unravelling the function of the Nha gene family)
    Industry, (co-I). June 2010 - 2011


    2011
    BBSRC (co-I), December 2011-2014 (Extraordinary pH - generation of extreme pH in living systems)
    BBSRC CASE Studentship (co-I)
    University of Glasgow Kelvin Smith Scholarship, 2011-15


    2012
    SULSA Translational Biology Theme Directorate, (co-I) 2012, HTS Award,     
    BBSRC Japan International Partnering Award, 2012-15 (Novel methodology for pest control using key regulators of insect survival against infection)


    2013
    BBSRC (co-I) 2013-17 (FlyAtlas2: a definitive, expanded NGS expression resource for the Drosophila community and beyond)
    BBSRC grant, 2013-16 (Functional genomics of the enigmatic stellate cell)


    2014
    BBSRC Flexible Interchange Award with industry, 2014-16
    BBSRC, Sparking Impact Award, (co-I) 2014


    2015
    University of Glasgow Knowledge Exchange Fund


Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1999
Number of items: 70.

2017

Leader, D. P. , Krause, S. A. , Pandit, A., Davies, S. A. and Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, (doi:10.1093/nar/gkx976) (PMID:29069479) (Early Online Publication)

Zandawala, M., Marley, R., Davies, S. A. and Nässel, D. R. (2017) Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Cellular and Molecular Life Sciences, (doi:10.1007/s00018-017-2682-y) (PMID:29043393) (Early Online Publication)

Terhzaz, S., Alford, L., Yeoh, J. G.C. , Marley, R., Dornan, A. J., Dow, J. A.T. and Davies, S. A. (2017) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, (doi:10.1002/ps.4663) (PMID:28714258) (Early Online Publication)

Yeoh, J. G.C. , Pandit, A. A., Zandawala, M., Nässel, D. R., Davies, S.-A. and Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi:10.1016/j.ibmb.2017.05.001) (PMID:28502574)

Davies, S. (2017) nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology. International Pest Control, 59(3), pp. 164-165.

2016

Overend, G., Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi:10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)

Halberg, K. A., Rainey, S. M., Veland, I. R., Neuert, H., Dornan, A. J., Klämbt, C., Davies, S.-A. and Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, 11266. (doi:10.1038/ncomms11266) (PMID:27072072) (PMCID:PMC4833865)

Cannell, E., Dornan, A. J., Halberg, K. A., Terhzaza, S., Dow, J. A.T. and Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi:10.1016/j.peptides.2016.02.004) (PMID:26896569) (PMCID:PMC4889782)

2015

Brinzer, R., Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S. and Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi:10.1016/j.ibmb.2015.09.009) (PMID:26474926)

Dow, J. A. T. and Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, p. 1. (doi:10.1016/j.ibmb.2015.10.013) (PMID:26518152)

Overend, G., Cabrero, P., Halberg, K. A.,, Ranford-Cartwright, L. C., Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi:10.1016/j.ibmb.2015.05.007) (PMID:26003916)

MacMillan, H. A., Andersen, J. L., Davies, S. A. and Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5, 18607. (doi:10.1038/srep18607) (PMID:26678786) (PMCID:PMC4683515)

Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G., Davies, S. A., Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi:10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)

Halberg, K., Terhzaz, S., Cabrero, P., Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi:10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)

Terhzaz, S., Teets, N., Cabrero, P., Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T., Denlinger, D. L. and Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112(9), pp. 2882-2887. (doi:10.1073/pnas.1501518112) (PMID:25730885) (PMCID:PMC4352776)

Terhzaz, S., Cabrero, P., Brinzer, R. A., Halberg, K. A., Dow, J. A.T. and Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, (doi:10.1016/j.ibmb.2015.06.002) (PMID:26073628) (PMCID:PMC4673087)

2014

Cabrero, P., Terhzaz, S., Romero, M. F., Davies, S. A., Blumenthal, E. M. and Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proceedings of the National Academy of Sciences of the United States of America, 111(39), pp. 14301-14306. (doi:10.1073/pnas.1412706111) (PMID:25228763) (PMCID:PMC4191759)

Terhzaz, S., Overend, G., Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi:10.1016/j.peptides.2013.08.004)

Davies, S.A., Cabrero, P., Overend, G., Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi:10.1242/jeb.090571) (PMID:24353211)

2013

Davies, S.A., Cabrero, P., Povsic, M., Johnston, N.R., Terhzaz, S. and Dow, J.A.T. (2013) Signaling by drosophila capa neuropeptides. General and Comparative Endocrinology, 188, pp. 60-66. (doi:10.1016/j.ygcen.2013.03.012)

Cabrero, P., Richmond, L., Nitabach, M., Davies, S.A. and Dow, J.A.T. (2013) A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in drosophila tubule stellate cells. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1757), Art. 20122943. (doi:10.1098/rspb.2012.2943)

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi:10.1073/pnas.1303004110)

Chintapalli, V.R., Wang, J., Herzyk, P., Davies, S.A. and Dow, J.A.T. (2013) Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. BMC Genomics, 14(518), (doi:10.1186/1471-2164-14-518)

2012

Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi:10.1523/JNEUROSCI.3286-12.2012)

Patel, U., Davies, S.A. and Myat, M.M. (2012) Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle. Biology Open, 1, pp. 507-515. (doi:10.1242/​bio.2012943)

Davies, S.A., Overend, G., Sebastian, S., Cundall, M., Cabrero, P., Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi:10.1016/j.jinsphys.2012.01.008)

Overend, G., Cabrero, P., Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi:10.1016/j.peptides.2011.08.019)

Kanao, T., Sawada, T., Davies, S., Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N. and Imai, Y. (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE, 7(2), e30958. (doi:10.1371/journal.pone.0030958)

Chintapalli, V., Terhzaz, S., Wang, J., Al Bratty, M., Watson, D.G., Herzyk, P., Davies, S.A. and Dow, J.A.T. (2012) Functional correlates of positional and gender-specific renal asymmetry in drosophila. PLoS ONE, 7(4), e32577. (doi:10.1371/journal.pone.0032577)

Terhzaz, S., Cabrero, P., Robben, J.H., Radford, J.C., Hudson, B.D., Milligan, G. , Dow, J.A.T. and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7(1), e29897. (doi:10.1371/journal.pone.0029897)

2010

Terhzaz, S., Finlayson, A. J., Stirrat, L., Yang, J., Tricoire, H., Woods, D. J., Dow, J. A.T. and Davies, S. A. (2010) Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cellular Signalling, 22(5), pp. 737-748. (doi:10.1016/j.cellsig.2009.12.009)

Terhzaz, S., Cabrero, P., Chintapalli, V.R., Davies, S.A. and Dow, J.A.T. (2010) Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiological Genomics, 41(1), pp. 33-41. (doi:10.1152/physiolgenomics.00147.2009)

Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A. and Morton, D.B. (2010) Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics, 186(1), pp. 183-196. (doi:10.1534/genetics.110.118166)

2009

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi:10.1016/j.yjmcc.2009.02.016)

Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi:10.1016/j.ygcen.2008.09.012)

Davies, S.A. and Terhzaz, S. (2009) Organellar calcium signalling mechanisms in Drosophila epithelial function. Journal of Experimental Biology, 212(3), pp. 387-400. (doi:10.1242/jeb.024513)

Stergiopoulos, K., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiological Genomics, 37(1), pp. 1-11. (doi:10.1152/physiolgenomics.90360.2008)

2008

Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi:10.1042/BJ20080560)

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi:10.1242/jcs.033084)

Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T. and Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP. Journal of Experimental Biology, 211, pp. 890-899. (doi:10.1242/jeb.014837)

2006

Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi:10.1242/jcs.02983)

Davies, S.-A. and Day, J.P. (2006) cGMP signalling in a transporting epithelium. Biochemical Society Transactions, 34, pp. 512-514. (doi:10.1042/BST0340512)

Davies, S. (2006) Signalling via cGMP: Lessons from Drosophila. Cellular Signalling, 18, pp. 409-421. (doi:10.1016/j.cellsig.2005.08.011)

Day, J., Houslay, M. and Davies, S. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393, pp. 481-488. (doi:10.1042/BJ20051505)

Dow, J. A.T. and Davies, S. A. (2006) The Malpighian tubule: Rapid insights from post-genomic biology. Journal of Insect Physiology, 52(4), pp. 365-378. (doi:10.1016/j.jinsphys.2005.10.007)

Southall, T. D., Terhzaz, S., Cabrero, P., Chintapalli, V. R., Evans, J. M., Dow, J. A.T. and Davies, S.-A. (2006) Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Physiological Genomics, 26(1), pp. 35-45. (doi:10.1152/physiolgenomics.00038.2006)

Terhzaz, S., Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi:10.1074/jbc.M603002200)

2005

Allan, A., Du, J., Davies, S. and Dow, J. (2005) Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiological Genomics, 22, pp. 128-138. (doi:10.1152/physiolgenomics.00233.2004)

Day, J., Dow, J., Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi:10.1042/BJ20050057)

Evans, J., Allan, A., Davies, S. and Dow, J. (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Journal of Experimental Biology, 208, pp. 3771-3783.

MacPherson, M., Pollock, V., Kean, L., Southall, T., Giannakou, M., Broderick, K., Dow, J., Hardie, R. and Davies, S. (2005) Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics, 169, pp. 1541-1552. (doi:10.1534/genetics.104.035139)

McGettigan, J. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology, 35, pp. 741-754. (doi:10.1016/j.ibmb.2005.02.017)

2004

Broderick, K., Kean, L., Dow, J., Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi:10.1074/jbc.M304679200)

Cabrero, P., Pollock, V., Davies, S. and Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects. Journal of Experimental Biology, 207, pp. 3299-3305. (doi:10.1242/jeb.01156)

Kerr, M., Davies, S. and Down, J. (2004) Cell-specific manipulation of second messengers: A toolbox for integrative physiology in Drosophila. Current Biology, 14, pp. 1468-1474. (doi:10.1016/j.cub.2004.08.020)

MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi:10.1242/jeb.01086)

MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi:10.1074/jbc.M405619200)

Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J. and Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera. Journal of Experimental Biology, 207, pp. 4135-4145. (doi:10.1242/jeb.01255)

Radford, J.H.C., Terhzaz, S., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Journal of Experimental Biology, 207, pp. 4573-4586. (doi:10.1242/jeb.01317)

Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S. and Dow, J. (2004) Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences of the United States of America, 101(37), pp. 13689-13693. (doi:10.1073/pnas.0403087101)

Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P. and Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology, 5,

2003

Broderick, K., MacPherson, M., Regulski, M., Tully, T., Dow, J. and Davies, S. (2003) Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. American Journal of Physiology: Cell Physiology, 285, C1207-C1218. (doi:10.1152/ajpcell.00123.2003)

Dow, J. and Davies, S. (2003) Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiological Reviews, 83, pp. 687-729. (doi:10.1152/physrev.00035.2002)

Pollock, V., Radford, J., Pyne, S., Hasan, G., Dow, J. and Davies, S. (2003) norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. Journal of Experimental Biology, 206, pp. 901-911. (doi:10.1242/jeb.00189)

2002

Cabrero, P., Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S. and Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology, 205, pp. 3799-3807.

Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A., Veenstra, J.A. and Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, R1297-R1307. (doi:10.1152/ajpregu.00584.2001)

Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi:10.1074/jbc.M203694200)

2001

Dow, J. and Davies, S. (2001) The Drosophila melanogaster malpighian tubule. Advances in Insect Physiology, 28, pp. 1-83.

MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J. and Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology: Cell Physiology, 280, C394-C407.

1999

Terhzaz, S., O'Connell, F. C., Pollock, V. P., Kean, L., Davies, S. A., Veenstra, J. A. and Dow, J. A. (1999) Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. Journal of Experimental Biology, 202(Pt 24), pp. 3667-3676. (PMID:10574744)

This list was generated on Fri Nov 24 00:46:48 2017 GMT.
Jump to: Articles
Number of items: 70.

Articles

Leader, D. P. , Krause, S. A. , Pandit, A., Davies, S. A. and Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, (doi:10.1093/nar/gkx976) (PMID:29069479) (Early Online Publication)

Zandawala, M., Marley, R., Davies, S. A. and Nässel, D. R. (2017) Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Cellular and Molecular Life Sciences, (doi:10.1007/s00018-017-2682-y) (PMID:29043393) (Early Online Publication)

Terhzaz, S., Alford, L., Yeoh, J. G.C. , Marley, R., Dornan, A. J., Dow, J. A.T. and Davies, S. A. (2017) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, (doi:10.1002/ps.4663) (PMID:28714258) (Early Online Publication)

Yeoh, J. G.C. , Pandit, A. A., Zandawala, M., Nässel, D. R., Davies, S.-A. and Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi:10.1016/j.ibmb.2017.05.001) (PMID:28502574)

Davies, S. (2017) nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology. International Pest Control, 59(3), pp. 164-165.

Overend, G., Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi:10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)

Halberg, K. A., Rainey, S. M., Veland, I. R., Neuert, H., Dornan, A. J., Klämbt, C., Davies, S.-A. and Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, 11266. (doi:10.1038/ncomms11266) (PMID:27072072) (PMCID:PMC4833865)

Cannell, E., Dornan, A. J., Halberg, K. A., Terhzaza, S., Dow, J. A.T. and Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi:10.1016/j.peptides.2016.02.004) (PMID:26896569) (PMCID:PMC4889782)

Brinzer, R., Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S. and Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi:10.1016/j.ibmb.2015.09.009) (PMID:26474926)

Dow, J. A. T. and Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, p. 1. (doi:10.1016/j.ibmb.2015.10.013) (PMID:26518152)

Overend, G., Cabrero, P., Halberg, K. A.,, Ranford-Cartwright, L. C., Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi:10.1016/j.ibmb.2015.05.007) (PMID:26003916)

MacMillan, H. A., Andersen, J. L., Davies, S. A. and Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5, 18607. (doi:10.1038/srep18607) (PMID:26678786) (PMCID:PMC4683515)

Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G., Davies, S. A., Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi:10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)

Halberg, K., Terhzaz, S., Cabrero, P., Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi:10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)

Terhzaz, S., Teets, N., Cabrero, P., Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T., Denlinger, D. L. and Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112(9), pp. 2882-2887. (doi:10.1073/pnas.1501518112) (PMID:25730885) (PMCID:PMC4352776)

Terhzaz, S., Cabrero, P., Brinzer, R. A., Halberg, K. A., Dow, J. A.T. and Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, (doi:10.1016/j.ibmb.2015.06.002) (PMID:26073628) (PMCID:PMC4673087)

Cabrero, P., Terhzaz, S., Romero, M. F., Davies, S. A., Blumenthal, E. M. and Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proceedings of the National Academy of Sciences of the United States of America, 111(39), pp. 14301-14306. (doi:10.1073/pnas.1412706111) (PMID:25228763) (PMCID:PMC4191759)

Terhzaz, S., Overend, G., Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi:10.1016/j.peptides.2013.08.004)

Davies, S.A., Cabrero, P., Overend, G., Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi:10.1242/jeb.090571) (PMID:24353211)

Davies, S.A., Cabrero, P., Povsic, M., Johnston, N.R., Terhzaz, S. and Dow, J.A.T. (2013) Signaling by drosophila capa neuropeptides. General and Comparative Endocrinology, 188, pp. 60-66. (doi:10.1016/j.ygcen.2013.03.012)

Cabrero, P., Richmond, L., Nitabach, M., Davies, S.A. and Dow, J.A.T. (2013) A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in drosophila tubule stellate cells. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1757), Art. 20122943. (doi:10.1098/rspb.2012.2943)

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi:10.1073/pnas.1303004110)

Chintapalli, V.R., Wang, J., Herzyk, P., Davies, S.A. and Dow, J.A.T. (2013) Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. BMC Genomics, 14(518), (doi:10.1186/1471-2164-14-518)

Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi:10.1523/JNEUROSCI.3286-12.2012)

Patel, U., Davies, S.A. and Myat, M.M. (2012) Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle. Biology Open, 1, pp. 507-515. (doi:10.1242/​bio.2012943)

Davies, S.A., Overend, G., Sebastian, S., Cundall, M., Cabrero, P., Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi:10.1016/j.jinsphys.2012.01.008)

Overend, G., Cabrero, P., Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi:10.1016/j.peptides.2011.08.019)

Kanao, T., Sawada, T., Davies, S., Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N. and Imai, Y. (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE, 7(2), e30958. (doi:10.1371/journal.pone.0030958)

Chintapalli, V., Terhzaz, S., Wang, J., Al Bratty, M., Watson, D.G., Herzyk, P., Davies, S.A. and Dow, J.A.T. (2012) Functional correlates of positional and gender-specific renal asymmetry in drosophila. PLoS ONE, 7(4), e32577. (doi:10.1371/journal.pone.0032577)

Terhzaz, S., Cabrero, P., Robben, J.H., Radford, J.C., Hudson, B.D., Milligan, G. , Dow, J.A.T. and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7(1), e29897. (doi:10.1371/journal.pone.0029897)

Terhzaz, S., Finlayson, A. J., Stirrat, L., Yang, J., Tricoire, H., Woods, D. J., Dow, J. A.T. and Davies, S. A. (2010) Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cellular Signalling, 22(5), pp. 737-748. (doi:10.1016/j.cellsig.2009.12.009)

Terhzaz, S., Cabrero, P., Chintapalli, V.R., Davies, S.A. and Dow, J.A.T. (2010) Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiological Genomics, 41(1), pp. 33-41. (doi:10.1152/physiolgenomics.00147.2009)

Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A. and Morton, D.B. (2010) Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics, 186(1), pp. 183-196. (doi:10.1534/genetics.110.118166)

Kettlewell, S., Cabrero, P., Nicklin, S.A., Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi:10.1016/j.yjmcc.2009.02.016)

Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi:10.1016/j.ygcen.2008.09.012)

Davies, S.A. and Terhzaz, S. (2009) Organellar calcium signalling mechanisms in Drosophila epithelial function. Journal of Experimental Biology, 212(3), pp. 387-400. (doi:10.1242/jeb.024513)

Stergiopoulos, K., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiological Genomics, 37(1), pp. 1-11. (doi:10.1152/physiolgenomics.90360.2008)

Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi:10.1042/BJ20080560)

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi:10.1242/jcs.033084)

Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T. and Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP. Journal of Experimental Biology, 211, pp. 890-899. (doi:10.1242/jeb.014837)

Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi:10.1242/jcs.02983)

Davies, S.-A. and Day, J.P. (2006) cGMP signalling in a transporting epithelium. Biochemical Society Transactions, 34, pp. 512-514. (doi:10.1042/BST0340512)

Davies, S. (2006) Signalling via cGMP: Lessons from Drosophila. Cellular Signalling, 18, pp. 409-421. (doi:10.1016/j.cellsig.2005.08.011)

Day, J., Houslay, M. and Davies, S. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393, pp. 481-488. (doi:10.1042/BJ20051505)

Dow, J. A.T. and Davies, S. A. (2006) The Malpighian tubule: Rapid insights from post-genomic biology. Journal of Insect Physiology, 52(4), pp. 365-378. (doi:10.1016/j.jinsphys.2005.10.007)

Southall, T. D., Terhzaz, S., Cabrero, P., Chintapalli, V. R., Evans, J. M., Dow, J. A.T. and Davies, S.-A. (2006) Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Physiological Genomics, 26(1), pp. 35-45. (doi:10.1152/physiolgenomics.00038.2006)

Terhzaz, S., Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi:10.1074/jbc.M603002200)

Allan, A., Du, J., Davies, S. and Dow, J. (2005) Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiological Genomics, 22, pp. 128-138. (doi:10.1152/physiolgenomics.00233.2004)

Day, J., Dow, J., Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi:10.1042/BJ20050057)

Evans, J., Allan, A., Davies, S. and Dow, J. (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Journal of Experimental Biology, 208, pp. 3771-3783.

MacPherson, M., Pollock, V., Kean, L., Southall, T., Giannakou, M., Broderick, K., Dow, J., Hardie, R. and Davies, S. (2005) Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics, 169, pp. 1541-1552. (doi:10.1534/genetics.104.035139)

McGettigan, J. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology, 35, pp. 741-754. (doi:10.1016/j.ibmb.2005.02.017)

Broderick, K., Kean, L., Dow, J., Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi:10.1074/jbc.M304679200)

Cabrero, P., Pollock, V., Davies, S. and Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects. Journal of Experimental Biology, 207, pp. 3299-3305. (doi:10.1242/jeb.01156)

Kerr, M., Davies, S. and Down, J. (2004) Cell-specific manipulation of second messengers: A toolbox for integrative physiology in Drosophila. Current Biology, 14, pp. 1468-1474. (doi:10.1016/j.cub.2004.08.020)

MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi:10.1242/jeb.01086)

MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi:10.1074/jbc.M405619200)

Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J. and Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera. Journal of Experimental Biology, 207, pp. 4135-4145. (doi:10.1242/jeb.01255)

Radford, J.H.C., Terhzaz, S., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Journal of Experimental Biology, 207, pp. 4573-4586. (doi:10.1242/jeb.01317)

Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S. and Dow, J. (2004) Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences of the United States of America, 101(37), pp. 13689-13693. (doi:10.1073/pnas.0403087101)

Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P. and Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology, 5,

Broderick, K., MacPherson, M., Regulski, M., Tully, T., Dow, J. and Davies, S. (2003) Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. American Journal of Physiology: Cell Physiology, 285, C1207-C1218. (doi:10.1152/ajpcell.00123.2003)

Dow, J. and Davies, S. (2003) Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiological Reviews, 83, pp. 687-729. (doi:10.1152/physrev.00035.2002)

Pollock, V., Radford, J., Pyne, S., Hasan, G., Dow, J. and Davies, S. (2003) norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. Journal of Experimental Biology, 206, pp. 901-911. (doi:10.1242/jeb.00189)

Cabrero, P., Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S. and Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology, 205, pp. 3799-3807.

Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A., Veenstra, J.A. and Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, R1297-R1307. (doi:10.1152/ajpregu.00584.2001)

Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi:10.1074/jbc.M203694200)

Dow, J. and Davies, S. (2001) The Drosophila melanogaster malpighian tubule. Advances in Insect Physiology, 28, pp. 1-83.

MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J. and Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology: Cell Physiology, 280, C394-C407.

Terhzaz, S., O'Connell, F. C., Pollock, V. P., Kean, L., Davies, S. A., Veenstra, J. A. and Dow, J. A. (1999) Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. Journal of Experimental Biology, 202(Pt 24), pp. 3667-3676. (PMID:10574744)

This list was generated on Fri Nov 24 00:46:48 2017 GMT.