Upcoming Events & Seminars
Upcoming Events & Seminars
Computational modeling and simulation of neuronal processes in neuronal aging and neuropathologies
Prof Sean Gillian Queisser, Temple University, USA
Location: Seminar Room 311B, School of Mathematics & Statistics, University of Glasgow
Date: Thursday, September 17 at 2:00 pm
Abstract: Neurons rely predominantly on electrical and calcium signaling to encode information and adapt for development, learning, and survival. During aging or pathological aging, such as in Alzheimer’s disease, neurons are known to change, among other things, their morphology, intracellular organization ,and biophysical properties. These changes can lead to pathological states leading, ultimately, to cell death. In this talk we introduce a coupled electrical and calcium model that can incorporate detailed cell morphology, intracellular organelles, as well as external electric fields, used to simulate and study a broad range of aging-related and pathological neuronal states. We cover four main applications, (1) the study of synaptic spines at the ultrastructural level, (2) improving transcranial magnetic stimulation (TMS), a clinically used medical device for addiction, epilepsy, and schizophrenia treatment, (3) changes in electrical and calcium signaling in aging neurons, and (4) the NMDA/TRPM4 receptor complex and its involvement in Alzheimer’s disease.
Future Events
If you would like to propose or help organise any future events then please reach out to the seminar organisers in the CMALS Executive Committee.
Past Events and Seminars
You can find more information about our previous events and seminars in the relevant sections on this website.