New Nature paper co-led by Professor Naveed Sattar

Published: 26 February 2020

Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk

Professor Naveed Sattar as one of five co-leads, and Paul Welsh were co-authors on a paper published Feb 2020 in Nature which reports how the most commonly used diabetes drug in the world, metformin, leads to weight loss.  The work sheds light on metformin’s ability to increase GDF-15 synthesis in the distal intestine and kidney which then signals to the brain stem to lessen appetite.  This peptide hormone is also of interest to heart failure and cancer specialists where substantially elevated levels may, paradoxically, lead to unintentional and harmful weight loss.  

First published: 26 February 2020

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