New findings from a three-year extension of the landmark Diabetes Remission Clinical Trial (DiRECT) have revealed that nearly a quarter (23%) of participants who were in remission from type 2 diabetes at two years in the original trial remained in remission at five years, no longer needing to use diabetes medications to manage their blood sugar levels. Those who were still in remission had an average weight loss of 8.9kg at five years.

The research revealed that the proportion of participants in remission after five years was more than three times that of the DiRECT control group, who did not take part in the original low-calorie diet programme or receive continued low-intensity weight management support in the extension trial.
The research, led by Professor Mike Lean, at the University of Glasgow, and Professor Roy Taylor, at Newcastle University and funded by Diabetes UK, will be presented at the Diabetes UK Professional Conference 2023 in Liverpool on 26 April.

South Asian male having a blood sugar test

The original DiRECT trial of a weight management programme for people with a diagnosis of type 2 diabetes within the last six years, involved a 12-week low-calorie formula diet, followed by support to gradually reintroduce healthy food and maintain weight loss. The landmark trial was the first to show that remission from type 2 diabetes is possible through a dietary intervention in primary care, with almost half (46%) of people in remission at one year, and 36% at two years.

In the extension study, to understand the longer-term benefits of the programme, 95 intervention group participants of the original two-year DiRECT study (48 of whom were in remission at the start of the extension) continued to receive support to help maintain weight loss over the next three years. They received nurse or dietitian appointments at their GP surgery every three months to review their weight, blood sugar levels and blood pressure, and were offered advice and support to maintain their weight loss.

Participants who regained over 2kg during years 3-5 were offered an additional package of support, available once each year, consisting of the low-calorie ‘soups and shakes’ diet for four weeks, followed by support while reintroducing normal meals.

During the three-year extension, 82 participants from the original DiRECT control group – who originally received best type 2 diabetes care according to guidelines – were advised to lose weight. Control participants did not receive the three-monthly appointments, or additional ‘soups and shakes’ packages during the extension period.

  • Data, available from 85 participants of the original DiRECT intervention group, revealed an average five-year weight loss of 6.1kg. Of the 48/85 participants who were in remission at the start of the extension period, 11 (23%) were still in remission at 5 years, with an average five-year weight loss of 8.9kg.
  • Data, available from 82 participants of the original DiRECT control group, showed an average five-year weight loss of 4.6kg, with 3.4% in remission.
  • Overall, the intervention group saw greater improvements in blood pressure and blood sugar levels, and fewer needed medication, compared to the control group.
  • The number of ‘serious adverse events’ (events resulting in hospital admission) in the intervention group was less than half that in the control group. The findings also support growing evidence that weight loss, and remission from type 2 diabetes, can prevent or delay the complications of diabetes.

Professor Mike Lean, at the University of Glasgow, said: “Type 2 diabetes causes a range of progressive and life-shortening complications, notably blindness, infections, amputations, kidney failure and heart failure. It affects over four million people in UK and accounts for about 10% of NHS funding. The DiRECT Extension has shown us that a substantial proportion of people, managed in primary care, can maintain sufficient weight loss to be free from the condition for up to 5 years.

“The weight management intervention also reduced blood pressure and the need for antihypertensive drugs. The findings are important both for individuals and for national considerations of healthcare costs. The programme used in DiRECT is a huge improvement on previous management of type 2 diabetes, but future studies must seek even better ways to help maintain weight loss.”

Professor Roy Taylor at Newcastle University, said: “The DiRECT five-year follow up shows that the rapid weight loss programme brings about considerable weight loss at five years with low-intensity support. The most important question now is how the follow-up programme can be even more successful at an affordable cost.”

Dr Elizabeth Robertson, Director of Research at Diabetes UK, said: “Diabetes UK is proud to be at the forefront of over a decade of pioneering research into type 2 diabetes remission. Our DiRECT study has been pivotal in transforming the lives of people with type 2 diabetes by showing that the condition can be put into remission through weight loss. The new findings from DiRECT confirm that for some people, it is possible to stay in remission for at least five years.

“For those who put type 2 diabetes into remission, it can be life-changing, offering a better chance of a healthier future. For those that aren’t able to go into remission, losing weight can still lead to major health benefits, including improved blood sugar levels, and reduced risk of serious diabetes complications such as heart attack and stroke.

“DiRECT inspired the NHS low-calorie diet programme, granting many more people with type 2 diabetes the opportunity to put the condition into remission. We now need to understand how best to support more people to maintain weight loss and stay in remission in the long term.”


Enquiries: ali.howard@glasgow.ac.uk or elizabeth.mcmeekin@glasgow.ac.uk / 0141 330 6557 or 0141 330 4831

First published: 19 April 2023

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