Drugomics - untargeted metabolomics as more versatile alternative for untargeted LC-MS/MS drug assays
Published: 12 January 2018
Non-adherence to cardiovascular medicines is particularly important as there is substantial evidence of harm caused upon non-adherence, whilst an improvement in adherence is associated with improvement in prognosis and reduction of cardiovascular events.
Non-adherence to cardiovascular medicines is particularly important as there is substantial evidence of harm caused upon non-adherence, whilst an improvement in adherence is associated with improvement in prognosis and reduction of cardiovascular events.
An objective test for drug adherence would be of great use in order to identify individuals who are truly non-adherent and will benefit from interventions to improve adherence. For precision medicine, there is a need for a comprehensive method for drug screening that addresses all these limitations of traditional drug assays.
Professor Sandosh Padmanabhan has demonstrated in a proof-of-concept study a novel method of drug screening that allows detection of drugs and their metabolites in spot urine samples directly from patients by integrating molecular networking into a mass spectrometry workflow by acquiring mass fragmentation data. The initial analysis has been completed and the study has now been extended the study to include a further 100 samples.
First published: 12 January 2018