Cardiovascular fibrosis platform
Published: 12 January 2018
Animal models of fibrosis, aimed at enhancing the understanding of the molecular and pathophysiological mechanisms underlying cardiac, vascular and renal fibrosis are a key focus of research supported by the Node.
Animal models of fibrosis, aimed at enhancing the understanding of the molecular and pathophysiological mechanisms underlying cardiac, vascular and renal fibrosis are a key focus of research supported by the Node.
Pathologists within the MRC Node have completed histological analysis of heart, vessels and kidneys in a humanized mouse model of vascular Nox5 expression and are working to develop a platform to assess cardiovascular and renal fibrosis and inflammation in experimental models.
In a second project novel approaches to study cardiac, vascular and renal fibrosis were used to assess fibrosis in experimental models. Based on the preliminary data Professor Rhian Touyz successfully obtained pump priming funding through a MRC Pathways to Discovery grant to complete the study.
First published: 12 January 2018