Professor Shireen Davies

  • Professor of Integrative Cell Signalling (Molecular Biosciences)

telephone: 01413302317
email: Shireen.Davies@glasgow.ac.uk

R325 Level 3, Institute of MC&SB, Davidson Building, Glasgow G12 8QQ

ORCID iDhttps://orcid.org/0000-0002-0472-1302

Biography

Shireen was born in Singapore and attended Convent of the Holy Infant Jesus, Singapore and Westonbirt School, England. She gained a BSc (Hons), Biochemistry 1st Class from the University of Aberdeen and a PhD in Biochemistry at the University of Glasgow. 

Personal Awards

  • University of Glasgow Faculty of Medicine Scholarship and Overseas Student Research Award
  • Overseas Student Research Award
  • BBSRC David Phillips Fellowship
  • BBSRC Flexible Interchange Award
  • BBSRC Royal Society of Edinburgh Enterprise Fellowship
  • Fellowship of the Royal Society of Edinburgh

Post-doctoral career

  • 1989-1990: Department of Biochemistry, University of Glasgow
  • 1990-1993: Career break
  • 1993-1996: Departments of Cell Biology and Genetics, University of Glasgow
  • 1995: Journal of Cell Science Travel Fellow, Institute of Neuroscience, University of Oregon, USA
  • 1996-2001: BBSRC David Phillips Fellow, Department of Genetics, University of Glasgow
  • 2002-2005: Senior Lecturer, Division of Molecular Genetics, Institute of Biomedical and Life Sciences,
    University of Glasgow
  • 2005-2009: Reader, Integrative and Systems Biology, Integrated Biology Division, Faculty of Biomedical and Life Sciences, University of Glasgow
  • 2009-current: Professor of Integrative Cell Signalling, University of Glasgow
  • 2015: Visiting Professor, Department of Molecular Medicine, Faculty of Medicine, University of Malaya

Research interests

I am interested in how organisms tolerate and survive environmental stress, and so use the model insect Drosophila melanogaster to understand this process from the molecular level to whole organisms and species. In particular, we seek to understand the key roles of peptide hormones (neuropeptides), which act on epithelial cells and tissues in stress survival. We utilise approaches including molecular and cellular biology, physiology, peptide analogues and the ‘omic' technologies (genomics, transcriptomics, metabolomics). Using these approaches in Drosophila, we can address fundamental questions of mechanisms of stress tolerance in vivo, which can also be applied to biomedicine (e.g. metabolic, oxidative stress, renal development). We can also increase understanding of insect physiology, and are working on novel insecticide targets for Food Security (insect pests of agriculture, horticulture and forestry), and for Human and Animal Health (insect vectors of disease) by working on pest insect species and by developing novel assays/screens.

Our research is supported by the Biotechnology and Biological Sciences Research Council (BBSRC); the European Union's Horizon 2020 funding programme - nEUROSTRESSPEP (Coordinator) and RenalTract; and by industry and other organisations.

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1999
Number of items: 79.

2021

Koyama, T., Terhzaz, S. , Naseem, M. T., Nagy, S., Rewitz, K., Dow, J. A.T. , Davies, S. A. and Halberg, K. V. (2021) A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila. Nature Communications, 12, 5178. (doi: 10.1038/s41467-021-25445-2) (PMID:34462441) (PMCID:PMC8405823)

2020

Cabrero, P. , Terhzaz, S. , Dornan, A. J. , Ghimire, S., Holmes, H. L., Turin, D. R., Romero, M. F., Davies, S. and Dow, J. A.T. (2020) Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Proceedings of the National Academy of Sciences of the United States of America, 117(3), pp. 1779-1787. (doi: 10.1073/pnas.1915943117) (PMID:31907321) (PMCID:PMC6983416)

2019

Ghimire, S., Terhzaz, S. , Cabrero, P. , Romero, M. F., Davies, S. and Dow, J. A.T. (2019) Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. American Journal of Physiology: Renal Physiology, 317(4), F930-F940. (doi: 10.1152/ajprenal.00551.2018) (PMID:31364377) (PMCID:PMC6843049)

Alford, L., Marley, R., Dornan, A. , Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment. Journal of Pest Science, 92, pp. 1123-1137. (doi: 10.1007/s10340-019-01100-0)

Alford, L., Marley, R., Dornan, A. , Pierre, J.-S., Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance. Pest Management Science, 75(6), pp. 1750-1759. (doi: 10.1002/ps.5372) (PMID:30734498) (PMCID:PMC6593983)

Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi: 10.1242/dev.178087) (PMID:31036543)

Davies, S.-A. , Cabrero, P. , Marley, R., Martinez-Corrales, G., Ghimire, S., Dornan, A. J. and Dow, J. A.T. (2019) Epithelial function in the Drosophila Malpighian tubule: an in vivo renal model. In: Vainio, S. (ed.) Kidney Organogenesis: Methods and Protocols. Series: Methods in molecular biology (1926). Humana Press: New York, NY, pp. 203-221. ISBN 9781493990207 (doi: 10.1007/978-1-4939-9021-4_17)

Dow, J. A.T. , Halberg, K. A., Terhzaz, S. and Davies, S. A. (2019) Drosophila as a model for neuroendocrine control of renal homeostasis. In: Ludwig, M. and Levkowitz, G. (eds.) Model Animals in Neuroendocrinology. Series: INF masterclass in neuroendocrinology series. Wiley: Hoboken, pp. 81-100. ISBN 9781119390947 (doi: 10.1002/9781119391128.ch4)

2018

Pandit, A. A. , Ragionieri, L., Marley, R., Yeoh, J. G.C. , Inward, D. J.G., Davies, S.-A. , Predel, R. and Dow, J. A.T. (2018) Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest. Insect Biochemistry and Molecular Biology, 101, pp. 94-107. (doi: 10.1016/j.ibmb.2018.08.003) (PMID:30165105)

Terhzaz, S. , Alford, L., Yeoh, J. G.C. , Marley, R., Dornan, A. J. , Dow, J. A.T. and Davies, S. A. (2018) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, 74(4), pp. 800-810. (doi: 10.1002/ps.4663) (PMID:28714258) (PMCID:PMC5888198)

Zandawala, M., Marley, R., Davies, S. A. and Nässel, D. R. (2018) Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Cellular and Molecular Life Sciences, 75(6), pp. 1099-1115. (doi: 10.1007/s00018-017-2682-y) (PMID:29043393)

2017

Leader, D. P. , Krause, S. A. , Pandit, A. , Davies, S. A. and Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, 46(D1), D809-D815. (doi: 10.1093/nar/gkx976) (PMID:29069479) (PMCID:PMC5753349)

Yeoh, J. G.C. , Pandit, A. A. , Zandawala, M., Nässel, D. R., Davies, S.-A. and Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi: 10.1016/j.ibmb.2017.05.001) (PMID:28502574)

Davies, S. (2017) nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology. International Pest Control, 59(3), pp. 164-165.

2016

Overend, G. , Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi: 10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)

Halberg, K. A., Rainey, S. M., Veland, I. R., Neuert, H., Dornan, A. J. , Klämbt, C., Davies, S.-A. and Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, 11266. (doi: 10.1038/ncomms11266) (PMID:27072072) (PMCID:PMC4833865)

Cannell, E., Dornan, A. J. , Halberg, K. A., Terhzaza, S. , Dow, J. A.T. and Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi: 10.1016/j.peptides.2016.02.004) (PMID:26896569) (PMCID:PMC4889782)

2015

MacMillan, H. A., Andersen, J. L., Davies, S. A. and Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5, 18607. (doi: 10.1038/srep18607) (PMID:26678786) (PMCID:PMC4683515)

Brinzer, R. , Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S. and Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi: 10.1016/j.ibmb.2015.09.009) (PMID:26474926)

Dow, J. A. T. and Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, p. 1. (doi: 10.1016/j.ibmb.2015.10.013) (PMID:26518152)

Overend, G. , Cabrero, P. , Halberg, K. A.,, Ranford-Cartwright, L. C. , Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007) (PMID:26003916)

Terhzaz, S. , Cabrero, P. , Brinzer, R. A. , Halberg, K. A., Dow, J. A.T. and Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, 67, pp. 38-46. (doi: 10.1016/j.ibmb.2015.06.002) (PMID:26073628) (PMCID:PMC4673087)

Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G. , Davies, S. A. , Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi: 10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)

Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi: 10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)

Terhzaz, S. , Teets, N., Cabrero, P. , Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T. , Denlinger, D. L. and Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112(9), pp. 2882-2887. (doi: 10.1073/pnas.1501518112) (PMID:25730885) (PMCID:PMC4352776)

2014

Cabrero, P. , Terhzaz, S. , Romero, M. F., Davies, S. A. , Blumenthal, E. M. and Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proceedings of the National Academy of Sciences of the United States of America, 111(39), pp. 14301-14306. (doi: 10.1073/pnas.1412706111) (PMID:25228763) (PMCID:PMC4191759)

Terhzaz, S. , Overend, G. , Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)

Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)

2013

Davies, S.A. , Cabrero, P. , Povsic, M., Johnston, N.R., Terhzaz, S. and Dow, J.A.T. (2013) Signaling by drosophila capa neuropeptides. General and Comparative Endocrinology, 188, pp. 60-66. (doi: 10.1016/j.ygcen.2013.03.012)

Cabrero, P. , Richmond, L., Nitabach, M., Davies, S.A. and Dow, J.A.T. (2013) A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in drosophila tubule stellate cells. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1757), Art. 20122943. (doi: 10.1098/rspb.2012.2943)

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)

Chintapalli, V.R., Wang, J., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2013) Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. BMC Genomics, 14(518), (doi: 10.1186/1471-2164-14-518)

2012

Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi: 10.1523/JNEUROSCI.3286-12.2012)

Patel, U., Davies, S.A. and Myat, M.M. (2012) Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle. Biology Open, 1, pp. 507-515. (doi: 10.1242/​bio.2012943)

Davies, S.A. , Overend, G. , Sebastian, S., Cundall, M., Cabrero, P. , Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi: 10.1016/j.jinsphys.2012.01.008) (PMID:22306292)

Overend, G. , Cabrero, P. , Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi: 10.1016/j.peptides.2011.08.019) (PMID:21893139)

Kanao, T., Sawada, T., Davies, S. , Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N. and Imai, Y. (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE, 7(2), e30958. (doi: 10.1371/journal.pone.0030958) (PMID:22393355) (PMCID:PMC3290610)

Chintapalli, V., Terhzaz, S. , Wang, J., Al Bratty, M., Watson, D.G., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2012) Functional correlates of positional and gender-specific renal asymmetry in drosophila. PLoS ONE, 7(4), e32577. (doi: 10.1371/journal.pone.0032577) (PMID:22496733) (PMCID:PMC3319558)

Terhzaz, S. , Cabrero, P. , Robben, J.H., Radford, J.C., Hudson, B.D. , Milligan, G. , Dow, J.A.T. and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7(1), e29897. (doi: 10.1371/journal.pone.0029897) (PMID:22253819) (PMCID:PMC3256212)

2010

Terhzaz, S., Finlayson, A. J., Stirrat, L., Yang, J., Tricoire, H., Woods, D. J., Dow, J. A.T. and Davies, S. A. (2010) Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cellular Signalling, 22(5), pp. 737-748. (doi: 10.1016/j.cellsig.2009.12.009) (PMID:20060894)

Terhzaz, S. , Cabrero, P. , Chintapalli, V.R., Davies, S.A. and Dow, J.A.T. (2010) Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiological Genomics, 41(1), pp. 33-41. (doi: 10.1152/physiolgenomics.00147.2009) (PMID:20009008) (PMCID:PMC2841493)

Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A. and Morton, D.B. (2010) Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics, 186(1), pp. 183-196. (doi: 10.1534/genetics.110.118166)

2009

Kettlewell, S., Cabrero, P., Nicklin, S.A. , Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi: 10.1016/j.yjmcc.2009.02.016) (PMID:19249308)

Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi: 10.1016/j.ygcen.2008.09.012) (PMID:18952086)

Davies, S.A. and Terhzaz, S. (2009) Organellar calcium signalling mechanisms in Drosophila epithelial function. Journal of Experimental Biology, 212(3), pp. 387-400. (doi: 10.1242/jeb.024513)

Stergiopoulos, K., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiological Genomics, 37(1), pp. 1-11. (doi: 10.1152/physiolgenomics.90360.2008) (PMID:19018044) (PMCID:PMC2661102)

2008

Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi: 10.1042/BJ20080560) (PMID:18503409)

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi: 10.1242/jcs.033084) (PMID:18628302)

Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T. and Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP. Journal of Experimental Biology, 211, pp. 890-899. (doi: 10.1242/jeb.014837) (PMID:18310115)

2006

Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi: 10.1242/jcs.02983) (PMID:16735441)

Davies, S.-A. and Day, J.P. (2006) cGMP signalling in a transporting epithelium. Biochemical Society Transactions, 34, pp. 512-514. (doi: 10.1042/BST0340512) (PMID:16856847)

Davies, S. (2006) Signalling via cGMP: Lessons from Drosophila. Cellular Signalling, 18, pp. 409-421. (doi: 10.1016/j.cellsig.2005.08.011) (PMID:16260119)

Day, J., Houslay, M. and Davies, S. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393, pp. 481-488. (doi: 10.1042/BJ20051505) (PMID:16232123) (PMCID:PMC1360698)

Dow, J. A.T. and Davies, S. A. (2006) The Malpighian tubule: Rapid insights from post-genomic biology. Journal of Insect Physiology, 52(4), pp. 365-378. (doi: 10.1016/j.jinsphys.2005.10.007) (PMID:16310213)

Southall, T. D., Terhzaz, S. , Cabrero, P. , Chintapalli, V. R., Evans, J. M., Dow, J. A.T. and Davies, S.-A. (2006) Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Physiological Genomics, 26(1), pp. 35-45. (doi: 10.1152/physiolgenomics.00038.2006) (PMID:16609144)

Terhzaz, S. , Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi: 10.1074/jbc.M603002200) (PMID:16670086)

2005

Allan, A., Du, J., Davies, S. and Dow, J. (2005) Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiological Genomics, 22, pp. 128-138. (doi: 10.1152/physiolgenomics.00233.2004) (PMID:15855386)

Day, J., Dow, J., Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi: 10.1042/BJ20050057) (PMID:15673286) (PMCID:PMC1186723)

Evans, J., Allan, A., Davies, S. and Dow, J. (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Journal of Experimental Biology, 208, pp. 3771-3783. (PMID:16169954)

MacPherson, M., Pollock, V., Kean, L., Southall, T., Giannakou, M., Broderick, K., Dow, J., Hardie, R. and Davies, S. (2005) Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics, 169, pp. 1541-1552. (doi: 10.1534/genetics.104.035139) (PMID:15695363) (PMCID:PMC1449567)

McGettigan, J. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology, 35, pp. 741-754. (doi: 10.1016/j.ibmb.2005.02.017) (PMID:15894191)

2004

Broderick, K., Kean, L., Dow, J. , Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi: 10.1074/jbc.M304679200)

Cabrero, P., Pollock, V., Davies, S. and Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects. Journal of Experimental Biology, 207, pp. 3299-3305. (doi: 10.1242/jeb.01156) (PMID:15326206)

Kerr, M., Davies, S. and Down, J. (2004) Cell-specific manipulation of second messengers: A toolbox for integrative physiology in Drosophila. Current Biology, 14, pp. 1468-1474. (doi: 10.1016/j.cub.2004.08.020) (PMID:15324663)

MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi: 10.1242/jeb.01086)

MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi: 10.1074/jbc.M405619200)

Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J. and Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera. Journal of Experimental Biology, 207, pp. 4135-4145. (doi: 10.1242/jeb.01255) (PMID:15498959)

Radford, J.H.C., Terhzaz, S. , Cabrero, P. , Davies, S.A. and Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Journal of Experimental Biology, 207, pp. 4573-4586. (doi: 10.1242/jeb.01317) (PMID:15579553)

Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S. and Dow, J. (2004) Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences of the United States of America, 101(37), pp. 13689-13693. (doi: 10.1073/pnas.0403087101) (PMID:15347816) (PMCID:PMC518814)

Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P. and Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology, 5, (PMID:15345053) (PMCID:PMC522876)

2003

Broderick, K., MacPherson, M., Regulski, M., Tully, T., Dow, J. and Davies, S. (2003) Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. American Journal of Physiology: Cell Physiology, 285, C1207-C1218. (doi: 10.1152/ajpcell.00123.2003)

Dow, J. and Davies, S. (2003) Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiological Reviews, 83, pp. 687-729. (doi: 10.1152/physrev.00035.2002)

Pollock, V., Radford, J., Pyne, S., Hasan, G., Dow, J. and Davies, S. (2003) norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. Journal of Experimental Biology, 206, pp. 901-911. (doi: 10.1242/jeb.00189)

2002

Cabrero, P. , Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S. and Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology, 205(24), pp. 3799-3807. (PMID:12432004)

Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A. , Veenstra, J.A. and Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, R1297-R1307. (doi: 10.1152/ajpregu.00584.2001)

Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi: 10.1074/jbc.M203694200)

2001

Dow, J. and Davies, S. (2001) The Drosophila melanogaster malpighian tubule. Advances in Insect Physiology, 28, pp. 1-83.

MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J. and Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology: Cell Physiology, 280, C394-C407.

1999

Terhzaz, S. , O'Connell, F. C., Pollock, V. P., Kean, L., Davies, S. A. , Veenstra, J. A. and Dow, J. A. (1999) Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. Journal of Experimental Biology, 202(Pt 24), pp. 3667-3676. (PMID:10574744)

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Number of items: 79.

Articles

Koyama, T., Terhzaz, S. , Naseem, M. T., Nagy, S., Rewitz, K., Dow, J. A.T. , Davies, S. A. and Halberg, K. V. (2021) A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila. Nature Communications, 12, 5178. (doi: 10.1038/s41467-021-25445-2) (PMID:34462441) (PMCID:PMC8405823)

Cabrero, P. , Terhzaz, S. , Dornan, A. J. , Ghimire, S., Holmes, H. L., Turin, D. R., Romero, M. F., Davies, S. and Dow, J. A.T. (2020) Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Proceedings of the National Academy of Sciences of the United States of America, 117(3), pp. 1779-1787. (doi: 10.1073/pnas.1915943117) (PMID:31907321) (PMCID:PMC6983416)

Ghimire, S., Terhzaz, S. , Cabrero, P. , Romero, M. F., Davies, S. and Dow, J. A.T. (2019) Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. American Journal of Physiology: Renal Physiology, 317(4), F930-F940. (doi: 10.1152/ajprenal.00551.2018) (PMID:31364377) (PMCID:PMC6843049)

Alford, L., Marley, R., Dornan, A. , Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment. Journal of Pest Science, 92, pp. 1123-1137. (doi: 10.1007/s10340-019-01100-0)

Alford, L., Marley, R., Dornan, A. , Pierre, J.-S., Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance. Pest Management Science, 75(6), pp. 1750-1759. (doi: 10.1002/ps.5372) (PMID:30734498) (PMCID:PMC6593983)

Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi: 10.1242/dev.178087) (PMID:31036543)

Pandit, A. A. , Ragionieri, L., Marley, R., Yeoh, J. G.C. , Inward, D. J.G., Davies, S.-A. , Predel, R. and Dow, J. A.T. (2018) Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest. Insect Biochemistry and Molecular Biology, 101, pp. 94-107. (doi: 10.1016/j.ibmb.2018.08.003) (PMID:30165105)

Terhzaz, S. , Alford, L., Yeoh, J. G.C. , Marley, R., Dornan, A. J. , Dow, J. A.T. and Davies, S. A. (2018) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, 74(4), pp. 800-810. (doi: 10.1002/ps.4663) (PMID:28714258) (PMCID:PMC5888198)

Zandawala, M., Marley, R., Davies, S. A. and Nässel, D. R. (2018) Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Cellular and Molecular Life Sciences, 75(6), pp. 1099-1115. (doi: 10.1007/s00018-017-2682-y) (PMID:29043393)

Leader, D. P. , Krause, S. A. , Pandit, A. , Davies, S. A. and Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, 46(D1), D809-D815. (doi: 10.1093/nar/gkx976) (PMID:29069479) (PMCID:PMC5753349)

Yeoh, J. G.C. , Pandit, A. A. , Zandawala, M., Nässel, D. R., Davies, S.-A. and Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi: 10.1016/j.ibmb.2017.05.001) (PMID:28502574)

Davies, S. (2017) nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology. International Pest Control, 59(3), pp. 164-165.

Overend, G. , Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi: 10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)

Halberg, K. A., Rainey, S. M., Veland, I. R., Neuert, H., Dornan, A. J. , Klämbt, C., Davies, S.-A. and Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, 11266. (doi: 10.1038/ncomms11266) (PMID:27072072) (PMCID:PMC4833865)

Cannell, E., Dornan, A. J. , Halberg, K. A., Terhzaza, S. , Dow, J. A.T. and Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi: 10.1016/j.peptides.2016.02.004) (PMID:26896569) (PMCID:PMC4889782)

MacMillan, H. A., Andersen, J. L., Davies, S. A. and Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5, 18607. (doi: 10.1038/srep18607) (PMID:26678786) (PMCID:PMC4683515)

Brinzer, R. , Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S. and Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi: 10.1016/j.ibmb.2015.09.009) (PMID:26474926)

Dow, J. A. T. and Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, p. 1. (doi: 10.1016/j.ibmb.2015.10.013) (PMID:26518152)

Overend, G. , Cabrero, P. , Halberg, K. A.,, Ranford-Cartwright, L. C. , Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007) (PMID:26003916)

Terhzaz, S. , Cabrero, P. , Brinzer, R. A. , Halberg, K. A., Dow, J. A.T. and Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, 67, pp. 38-46. (doi: 10.1016/j.ibmb.2015.06.002) (PMID:26073628) (PMCID:PMC4673087)

Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G. , Davies, S. A. , Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi: 10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)

Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi: 10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)

Terhzaz, S. , Teets, N., Cabrero, P. , Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T. , Denlinger, D. L. and Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112(9), pp. 2882-2887. (doi: 10.1073/pnas.1501518112) (PMID:25730885) (PMCID:PMC4352776)

Cabrero, P. , Terhzaz, S. , Romero, M. F., Davies, S. A. , Blumenthal, E. M. and Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proceedings of the National Academy of Sciences of the United States of America, 111(39), pp. 14301-14306. (doi: 10.1073/pnas.1412706111) (PMID:25228763) (PMCID:PMC4191759)

Terhzaz, S. , Overend, G. , Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)

Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)

Davies, S.A. , Cabrero, P. , Povsic, M., Johnston, N.R., Terhzaz, S. and Dow, J.A.T. (2013) Signaling by drosophila capa neuropeptides. General and Comparative Endocrinology, 188, pp. 60-66. (doi: 10.1016/j.ygcen.2013.03.012)

Cabrero, P. , Richmond, L., Nitabach, M., Davies, S.A. and Dow, J.A.T. (2013) A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in drosophila tubule stellate cells. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1757), Art. 20122943. (doi: 10.1098/rspb.2012.2943)

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)

Chintapalli, V.R., Wang, J., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2013) Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. BMC Genomics, 14(518), (doi: 10.1186/1471-2164-14-518)

Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi: 10.1523/JNEUROSCI.3286-12.2012)

Patel, U., Davies, S.A. and Myat, M.M. (2012) Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle. Biology Open, 1, pp. 507-515. (doi: 10.1242/​bio.2012943)

Davies, S.A. , Overend, G. , Sebastian, S., Cundall, M., Cabrero, P. , Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi: 10.1016/j.jinsphys.2012.01.008) (PMID:22306292)

Overend, G. , Cabrero, P. , Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi: 10.1016/j.peptides.2011.08.019) (PMID:21893139)

Kanao, T., Sawada, T., Davies, S. , Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N. and Imai, Y. (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE, 7(2), e30958. (doi: 10.1371/journal.pone.0030958) (PMID:22393355) (PMCID:PMC3290610)

Chintapalli, V., Terhzaz, S. , Wang, J., Al Bratty, M., Watson, D.G., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2012) Functional correlates of positional and gender-specific renal asymmetry in drosophila. PLoS ONE, 7(4), e32577. (doi: 10.1371/journal.pone.0032577) (PMID:22496733) (PMCID:PMC3319558)

Terhzaz, S. , Cabrero, P. , Robben, J.H., Radford, J.C., Hudson, B.D. , Milligan, G. , Dow, J.A.T. and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7(1), e29897. (doi: 10.1371/journal.pone.0029897) (PMID:22253819) (PMCID:PMC3256212)

Terhzaz, S., Finlayson, A. J., Stirrat, L., Yang, J., Tricoire, H., Woods, D. J., Dow, J. A.T. and Davies, S. A. (2010) Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cellular Signalling, 22(5), pp. 737-748. (doi: 10.1016/j.cellsig.2009.12.009) (PMID:20060894)

Terhzaz, S. , Cabrero, P. , Chintapalli, V.R., Davies, S.A. and Dow, J.A.T. (2010) Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiological Genomics, 41(1), pp. 33-41. (doi: 10.1152/physiolgenomics.00147.2009) (PMID:20009008) (PMCID:PMC2841493)

Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A. and Morton, D.B. (2010) Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics, 186(1), pp. 183-196. (doi: 10.1534/genetics.110.118166)

Kettlewell, S., Cabrero, P., Nicklin, S.A. , Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi: 10.1016/j.yjmcc.2009.02.016) (PMID:19249308)

Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi: 10.1016/j.ygcen.2008.09.012) (PMID:18952086)

Davies, S.A. and Terhzaz, S. (2009) Organellar calcium signalling mechanisms in Drosophila epithelial function. Journal of Experimental Biology, 212(3), pp. 387-400. (doi: 10.1242/jeb.024513)

Stergiopoulos, K., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiological Genomics, 37(1), pp. 1-11. (doi: 10.1152/physiolgenomics.90360.2008) (PMID:19018044) (PMCID:PMC2661102)

Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi: 10.1042/BJ20080560) (PMID:18503409)

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi: 10.1242/jcs.033084) (PMID:18628302)

Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T. and Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP. Journal of Experimental Biology, 211, pp. 890-899. (doi: 10.1242/jeb.014837) (PMID:18310115)

Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi: 10.1242/jcs.02983) (PMID:16735441)

Davies, S.-A. and Day, J.P. (2006) cGMP signalling in a transporting epithelium. Biochemical Society Transactions, 34, pp. 512-514. (doi: 10.1042/BST0340512) (PMID:16856847)

Davies, S. (2006) Signalling via cGMP: Lessons from Drosophila. Cellular Signalling, 18, pp. 409-421. (doi: 10.1016/j.cellsig.2005.08.011) (PMID:16260119)

Day, J., Houslay, M. and Davies, S. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393, pp. 481-488. (doi: 10.1042/BJ20051505) (PMID:16232123) (PMCID:PMC1360698)

Dow, J. A.T. and Davies, S. A. (2006) The Malpighian tubule: Rapid insights from post-genomic biology. Journal of Insect Physiology, 52(4), pp. 365-378. (doi: 10.1016/j.jinsphys.2005.10.007) (PMID:16310213)

Southall, T. D., Terhzaz, S. , Cabrero, P. , Chintapalli, V. R., Evans, J. M., Dow, J. A.T. and Davies, S.-A. (2006) Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Physiological Genomics, 26(1), pp. 35-45. (doi: 10.1152/physiolgenomics.00038.2006) (PMID:16609144)

Terhzaz, S. , Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi: 10.1074/jbc.M603002200) (PMID:16670086)

Allan, A., Du, J., Davies, S. and Dow, J. (2005) Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiological Genomics, 22, pp. 128-138. (doi: 10.1152/physiolgenomics.00233.2004) (PMID:15855386)

Day, J., Dow, J., Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi: 10.1042/BJ20050057) (PMID:15673286) (PMCID:PMC1186723)

Evans, J., Allan, A., Davies, S. and Dow, J. (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Journal of Experimental Biology, 208, pp. 3771-3783. (PMID:16169954)

MacPherson, M., Pollock, V., Kean, L., Southall, T., Giannakou, M., Broderick, K., Dow, J., Hardie, R. and Davies, S. (2005) Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics, 169, pp. 1541-1552. (doi: 10.1534/genetics.104.035139) (PMID:15695363) (PMCID:PMC1449567)

McGettigan, J. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology, 35, pp. 741-754. (doi: 10.1016/j.ibmb.2005.02.017) (PMID:15894191)

Broderick, K., Kean, L., Dow, J. , Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi: 10.1074/jbc.M304679200)

Cabrero, P., Pollock, V., Davies, S. and Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects. Journal of Experimental Biology, 207, pp. 3299-3305. (doi: 10.1242/jeb.01156) (PMID:15326206)

Kerr, M., Davies, S. and Down, J. (2004) Cell-specific manipulation of second messengers: A toolbox for integrative physiology in Drosophila. Current Biology, 14, pp. 1468-1474. (doi: 10.1016/j.cub.2004.08.020) (PMID:15324663)

MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi: 10.1242/jeb.01086)

MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi: 10.1074/jbc.M405619200)

Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J. and Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera. Journal of Experimental Biology, 207, pp. 4135-4145. (doi: 10.1242/jeb.01255) (PMID:15498959)

Radford, J.H.C., Terhzaz, S. , Cabrero, P. , Davies, S.A. and Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Journal of Experimental Biology, 207, pp. 4573-4586. (doi: 10.1242/jeb.01317) (PMID:15579553)

Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S. and Dow, J. (2004) Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences of the United States of America, 101(37), pp. 13689-13693. (doi: 10.1073/pnas.0403087101) (PMID:15347816) (PMCID:PMC518814)

Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P. and Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology, 5, (PMID:15345053) (PMCID:PMC522876)

Broderick, K., MacPherson, M., Regulski, M., Tully, T., Dow, J. and Davies, S. (2003) Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. American Journal of Physiology: Cell Physiology, 285, C1207-C1218. (doi: 10.1152/ajpcell.00123.2003)

Dow, J. and Davies, S. (2003) Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiological Reviews, 83, pp. 687-729. (doi: 10.1152/physrev.00035.2002)

Pollock, V., Radford, J., Pyne, S., Hasan, G., Dow, J. and Davies, S. (2003) norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. Journal of Experimental Biology, 206, pp. 901-911. (doi: 10.1242/jeb.00189)

Cabrero, P. , Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S. and Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology, 205(24), pp. 3799-3807. (PMID:12432004)

Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A. , Veenstra, J.A. and Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, R1297-R1307. (doi: 10.1152/ajpregu.00584.2001)

Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi: 10.1074/jbc.M203694200)

Dow, J. and Davies, S. (2001) The Drosophila melanogaster malpighian tubule. Advances in Insect Physiology, 28, pp. 1-83.

MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J. and Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology: Cell Physiology, 280, C394-C407.

Terhzaz, S. , O'Connell, F. C., Pollock, V. P., Kean, L., Davies, S. A. , Veenstra, J. A. and Dow, J. A. (1999) Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. Journal of Experimental Biology, 202(Pt 24), pp. 3667-3676. (PMID:10574744)

Book Sections

Davies, S.-A. , Cabrero, P. , Marley, R., Martinez-Corrales, G., Ghimire, S., Dornan, A. J. and Dow, J. A.T. (2019) Epithelial function in the Drosophila Malpighian tubule: an in vivo renal model. In: Vainio, S. (ed.) Kidney Organogenesis: Methods and Protocols. Series: Methods in molecular biology (1926). Humana Press: New York, NY, pp. 203-221. ISBN 9781493990207 (doi: 10.1007/978-1-4939-9021-4_17)

Dow, J. A.T. , Halberg, K. A., Terhzaz, S. and Davies, S. A. (2019) Drosophila as a model for neuroendocrine control of renal homeostasis. In: Ludwig, M. and Levkowitz, G. (eds.) Model Animals in Neuroendocrinology. Series: INF masterclass in neuroendocrinology series. Wiley: Hoboken, pp. 81-100. ISBN 9781119390947 (doi: 10.1002/9781119391128.ch4)

This list was generated on Fri Jun 9 15:53:29 2023 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Functional genomics of the insect epitheliome
    Biotechnology and Biological Sciences Research Council
    2021 - 2024
     
  • When are two cells better than one? A comparative approach to insect renal function
    Biotechnology and Biological Sciences Research Council
    2021 - 2024
     
  • High Growth Spin Out BioPesticides Discovery and Development Venture
    Scottish Enterprise
    2019 - 2020
     
  • BBSRC-FAPESP Joint Funding of Research
    Biotechnology and Biological Sciences Research Council
    2019 - 2021
     
  • Market assessment for Opportunities for Novel Models for Kidney Disease Drug Discovery & Nephrotoxicity Assessment
    Medical Research Council
    2018 - 2019
     
  • SE Early Stage Delevopment - Diligence on Biopesticides Discovery (D3)
    Scottish Enterprise
    2018 - 2019
     
  • Plasma Agriculture for pesticide reduction (STFC IPS)
    Science and Technology Facilities Council
    2018 - 2020
     
  • Multi-omic approaches to understand the evolution of insecticide resistance in Spodoptera frugiperda and Euschistus heros: Towards effective Insecticide Resistance Management (IRM) in Brazilian agri-ecosystems.
    Biotechnology and Biological Sciences Research Council
    2018 - 2019
     
  • Excellence with Impact - internal award
    Biotechnology and Biological Sciences Research Council
    2018 - 2019
     
  • ISCF Agri-Food Technology Catalyst Seeding Catalyst Award
    Biotechnology and Biological Sciences Research Council
    2017 - 2018
     
  • FlyMet.org - a tissue-based metabolomic online resource for the Drosophila and systems biology communities
    Biotechnology and Biological Sciences Research Council
    2017 - 2020
     
  • Functional analysis of insect neuropeptide G protein-coupled receptors
    Biotechnology and Biological Sciences Research Council
    2017 - 2020
     
  • SFC-GCRF: SCePTRe: Sustainable management of Crop PesTs in bRazil
    Scottish Funding Council
    2016 - 2017
     
  • nEUROSTRESSPEP
    European Commission
    2015 - 2019
     
  • RENALTRACT
    European Commission
    2015 - 2019
     
  • New approaches for insect control for Food Security
    Biotechnology and Biological Sciences Research Council
    2014 - 2016
     
  • Identifying new leads for a major medical problem, using a unique in vivo model for kidney stones - Sparking Impact Award
    Biotechnology and Biological Sciences Research Council
    2014 - 2014
     
  • FlyAtlas2: a definitive, expanded NGS expression resource for the Drosophila community and beyond.
    Biotechnology and Biological Sciences Research Council
    2013 - 2018
     
  • Functional Genomics of the enigmatic stellate cell.
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Japan-Systems Approaches to Addressing Food Security: Novel methodology for pest control using key regulators of insect survival against infection
    Biotechnology and Biological Sciences Research Council
    2012 - 2015
     
  • A new direction for insect control: transporters as novel targets for insecticidal compunds.
    Scottish Universities Life Sciences Alliance
    2012 - 2013
     
  • Extraordinary pH - the mechanism of generation of pH 12 in living systems
    Biotechnology and Biological Sciences Research Council
    2012 - 2014
     
  • Unravelling the function of the Nha gene family
    Biotechnology and Biological Sciences Research Council
    2010 - 2013
     
  • Epithelial stress sensors: novel roles for cytochrome P450s and organellar calcium in integrated stress and immune responses.
    Biotechnology and Biological Sciences Research Council
    2009 - 2013
     
  • Genetic, proteomic and functional analysis of junctional complexes in Drosophila
    Biotechnology and Biological Sciences Research Council
    2008 - 2011
     
  • Cyclic nucleotide signalling in innate immunity
    Biotechnology and Biological Sciences Research Council
    2007 - 2010
     
  • Spatiotemporal filtering in calcium control of mitochondrial function
    Biotechnology and Biological Sciences Research Council
    2006 - 2009
     
  • Investigation of calcium signalling in sarcoplasmic riticulum of cardiac myocytes using a novel targeted reporter
    Biotechnology and Biological Sciences Research Council
    2005 - 2008
     
  • Exploration of cyclic 3', 5' guanosine monophosphate (cGMP) signalling dynamics in vivo
    Biotechnology and Biological Sciences Research Council
    2004 - 2008
     
  • Confocal laser scanning microscope
    Biotechnology and Biological Sciences Research Council
    2003 - 2006
     
  • Comparative integrative physiology of novel branches of the NA+/H+ exchanger family
    Biotechnology and Biological Sciences Research Council
    2003 - 2006
     
  • Function of intracellular calcium pools in renal transport - unravelling complexities using targeted calcium reporters
    Biotechnology and Biological Sciences Research Council
    2003 - 2006
     

Teaching

•    Deputy Coordinator, Masters in Food Security
•    Level 4 Biochemistry Central Approaches in Biochemistry Option

Additional information

Grant Advisory Board

  • 2019: The Research Council of Norway - grants panel
  • 2019 - present: FWO (Research Foundation - Flanders) - Chair, Bio2 Fellowships Panel
  • 2016 - 2017: FWO (Research Foundation - Flanders) - SB Fellowships Panel
  • 2016 - present: BBSRC - Core Panel Member Committee E - Fellowships and personal awards
  • 2015 - present: European Commission - MCSA ITN and IF schemes evaluator
  • 2015 - 2018: FWO (Research Foundation - Flanders) - Core Panel Member - Bio2 Grants and Fellowships Panel
  • 2010 - 2014: BBSRC - Core Panel Member Committee D - Molecules, Cells and Industrial Biotechnology

Invited International Presentations

  • 2018: German Zoological International Conference, Griefswald
  • 2017: Research Triangle Park, North Carolina, USA - Industry workshop - Sustainable management of crop pests in Brazil
  • 2017: The Royal Society - Buckinghamshire ‘Evolution and functional biology of neuropeptide signalling: from genomes to behaviour’
  • 2016: Rehovot, Israel - Weizmann Institute for Science Innovations in Crop Protection
  • 2016: Leuven, Belgium - Conference of European Comparative Endocrinologists State of the Art Lecture
  • 2015: Brussels, Belgium - European Commission Coordinators Day
  • 2015: Sendai, Japan - Organiser, 2nd Young Researchers Conference, Tohoku University, BBSRC
  • 2015: Research Triangle Park, North Carolina, USA - Industry
  • 2015: Kuala Lumpur, Malaysia - University of Malaya
  • 2015: Myanmar - Invertebrate Neuropeptide Conference
  • 2014: Rennes, France - Conference of European Comparative Endocrinologists, State of the Art Lecture
  • 2014: Kuala Lumpur, Malaysia - University of Malaya Department of Molecular Medicine
  • 2014: Glasgow, Scotland, UK - Organiser, International conference, "The Epitheliome: potential new targets for insecticides?", BBSRC and Japan Science and Technology Agency
  • 2013: Barcelona, Spain - State of the Art Lecture, Homeostasis Symposium, International Conference of Comparative Endocrinology
  • 2013: Switzerland - Stress: challenging homeostasis, Journal of Experimental Biology
  • 2013: Thailand - Invertebrate Neuropeptide Conference
  • 2013: Oxford, England, UK - University of Oxford
  • 2013: Switzerland - Organiser, International conference, 'Stress: challenging homeostasis', Company of Biologists and Journal of Experimental Biology
  • 2013: Sendai, Japan - Organiser, Young Researchers’ Conference, Tohoku University, BBSRC
  • 2012: Zurich, Switzerland - Conference of European Comparative Endocrinologists
  • 2012: Sendai, Japan - Graduate School of Pharmaceutical Sciences, Tohoku University
  • 2012: Glasgow, Scotland, UK - Festschrift, Professor Miles Houslay
  • 2011: Glasgow, Scotland, UK - Scottish Vitae Young Researchers Network Conference, University of Glasgow
  • 2011: East Malaysia - Invertebrate Neuropeptide Conference
  • 2011: Glasgow, Scotland, UK - Society for Experimental Biology International Meeting
  • 2011: Paisley, Scotland, UK - Scottish Funding Council Equality Conference
  • 2010: London, England, UK - Leadership Conference, Imperial College
  • 2010: Glasgow, Scotland, UK - Wellcome Centre for Molecular Parasitology, University of Glasgow
  • 2010: Pecs, Hungary - Conference of European Comparative Endocrinologists, State of the Art Lecture
  • 2008: Deidesheim, Germany - BASF Symposium
  • 2008: Marseille, France - Society for Experimental Biology International Meeting
  • 2006: Maine, USA - Invited seminar speaker at Gordon Conference on Phosphodiesterases
  • 2006: Cambridge, England, UK - Invited seminar and participant in Biochemical Society meeting on cAMP compartmentalization
  • 2006: San Diego, California, USA - Invited seminar speaker at the American Society of Nephrology meeting
  • 2005: Barcelona, Spain - Co-organiser of the Insect Physiology symposium, Society for Experimental Biology International Meeting

Prizes, Awards and Distinctions

  • : BBSRC - Royal Society of Edinburgh Enterprise Fellowship
  • : Fellowship of the Royal Society of Edinburgh
  • : Overseas Student Research Award
  • : University of Glasgow - Faculty of Medicine Scholarship
  • : BBSRC - David Phillips Fellowship
  • : BBSRC - Flexible Interchange Award