Dr Nicole Perry-Hauser
- Lecturer (Molecular Biosciences)
email:
Nicole.Perry-Hauser@glasgow.ac.uk
pronouns:
She/her/hers
Biography
I am a Lecturer (Research & Teaching Track) at the University of Glasgow in the School of Molecular Biosciences, where I am building an independent scientific research career focused on adhesion G protein-coupled receptor (aGPCR) biology. Despite their pharmacological tractability, there are currently no drugs approved for targeting aGPCRs, and their fundamental molecular mechanisms remain poorly understood. I lead a research program that addresses these gaps in knowledge, with a particular emphasis on the role of aGPCRs in neuropsychiatric disorders.
I completed my PhD in the Department of Pharmacology at Vanderbilt University under the co-mentorship of Dr. Vsevolod Gurevich and Dr. T.M. Iverson. My research focused on the arrestins, adaptor proteins involved in the desensitization and internalization of G protein-coupled receptors. After completing my PhD, I joined Dr. Jonathan A. Javitch’s laboratory at Columbia University in the Department of Psychiatry, where I began investigating aGPCRs. My currect research investigates the role of aGPCR latrophilin-3 in modulating dopaminergic neurotransmission.
ORCID: https://orcid.org/0000-0003-3130-3023
Research interests
Adhesion G Protein-Coupled Receptors
Neuropsychiatric disorders
Signal Transduction
Rodent Models
Research groups
Publications
Prior publications
Article
Hyunggu Hahn, Carole Daly, John Little, IV, Nicole A Perry-Hauser, Emmanuel Flores-Espinoza, Asuka Inoue, Bianca Plouffe, Alex RB Thomsen (2025) Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration eLife Crossref. (doi: 10.7554/eLife.99373.3)
Nicole A. Perry-Hauser, Jonathan R. Du Rand, Kuo Hao Lee, Lei Shi, Jonathan A. Javitch (2025) N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3 Journal of Biological Chemistry Nicole A. Perry-Hauser (Perry). ISSN 0021-9258 (doi: 10.1016/j.jbc.2025.108174)
Hyunggu Hahn, Carole Daly, John Little, IV, Nicole A Perry-Hauser, Emmanuel Flores-Espinoza, Asuka Inoue, Bianca Plouffe, Alex Rojas Bie Thomsen (2024) Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration Crossref. (doi: 10.7554/eLife.99373.1)
Perry-Hauser, N., Maudsley, S., Berchiche, Y.A., Slosky, L.M. (2024) Editorial: GPCRs: signal transduction Frontiers in Molecular Biosciences Scopus - Elsevier. ISSN 2296889X (doi: 10.3389/fmolb.2024.1403161)
Daniel T Pederick, Nicole A Perry-Hauser, Huyan Meng, Zhigang He, Jonathan A Javitch, Liqun Luo (2023) Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons eLife Crossref. (doi: 10.7554/eLife.83529)
Perry-Hauser, N.A., VanDyck, M.W., Lee, K.H., Shi, L., Javitch, J.A. (2022) Disentangling autoproteolytic cleavage from tethered agonist–dependent activation of the adhesion receptor ADGRL3 Journal of Biological Chemistry Scopus - Elsevier. ISSN 1083351X 00219258 (doi: 10.1016/j.jbc.2022.102594)
Perry-Hauser, N.A., Kaoud, T.S., Stoy, H., Zhan, X., Chen, Q., Dalby, K.N., Iverson, T.M., Gurevich, V.V., Gurevich, E.V. (2022) Short Arrestin-3-Derived Peptides Activate JNK3 in Cells International Journal of Molecular Sciences Scopus - Elsevier. ISSN 14220067 16616596 (doi: 10.3390/ijms23158679)
Perry-Hauser, N.A. et al. (2022) The Two Non-Visual Arrestins Engage ERK2 Differently Journal of Molecular Biology Scopus - Elsevier. ISSN 10898638 00222836 (doi: 10.1016/j.jmb.2022.167465)
Bender, B.J., Bock, A., Nesheva, D.N., Perry-Hauser, N.A. (2021) Viewpoints on the First Transatlantic GPCR Symposium for Early-Career Investigators ACS Pharmacology and Translational Science Scopus - Elsevier. ISSN 25759108 (doi: 10.1021/acsptsci.1c00203)
Signe Mathiasen et al. (2020) Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3 Nature Chemical Biology Crossref. (doi: 10.1038/s41589-020-0649-z)
(2020) Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor Proceedings of the National Academy of Sciences Nicole A. Perry-Hauser (Perry). ISSN 26928205 (doi: 10.1101/2020.03.03.971846)
Mathiasen, S. et al. (2020) G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3 Nature Chemical Biology Scopus - Elsevier. ISSN 15524469 15524450 (doi: 10.1038/s41589-020-0617-7)
(2019) Arrestin-3 interaction with maternal embryonic leucine-zipper kinase Cellular Signalling Nicole A. Perry-Hauser (Perry). ISSN 0898-6568 (doi: 10.1016/j.cellsig.2019.109366)
(2019) A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation ACS Chemical Biology Nicole A. Perry-Hauser (Perry). ISSN 1554-8937 (doi: 10.1021/acschembio.9b00093)
(2019) Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification Proceedings of the National Academy of Sciences Nicole A. Perry-Hauser (Perry). ISSN 1091-6490 (doi: 10.1073/pnas.1819230116)
(2018) The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains Biochemistry Nicole A. Perry-Hauser (Perry). ISSN 1520-4995 (doi: 10.1021/acs.biochem.8b00836)
(2017) Structural basis of arrestin-3 activation and signaling Nature Communications Nicole A. Perry-Hauser (Perry). ISSN 2041-1723 (doi: 10.1038/s41467-017-01218-8)
(2017) Hepatic β-arrestin 2 is essential for maintaining euglycemia Journal of Clinical Investigation Nicole A. Perry-Hauser (Perry). ISSN 1558-8238 (doi: 10.1172/jci92913)
(2017) β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions Nature Communications Nicole A. Perry-Hauser (Perry). ISSN 2041-1723 (doi: 10.1038/ncomms14295)
(2016) Peptide mini-scaffold facilitates JNK3 activation in cells Scientific Reports Nicole A. Perry-Hauser (Perry). ISSN 2045-2322 (doi: 10.1038/srep21025)
Book Section
Nicole A. Perry-Hauser, Xuanzhi Zhan, T.M. Iverson (2022) Arrestin scaffolding and activation of MAPK cascades Crossref. (doi: 10.1016/B978-0-323-85756-7.00001-7)
Perry-Hauser, N.A., Asher, W.B., Hauge Pedersen, M., Javitch, J.A. (2021) Assays for detecting arrestin interaction with GPCRs Methods in Cell Biology Scopus - Elsevier. ISBN 9780128233511 ISSN 0091679X (doi: 10.1016/bs.mcb.2021.06.007)
(2019) Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin Beta-Arrestins Nicole A. Perry-Hauser (Perry). ISBN 9781493991587 ISSN 1940-6029 (doi: 10.1007/978-1-4939-9158-7_7)
(2017) Monofunctional elements of multi-functional arrestin proteins. Ch 18 The structural basis of arrestin functions Nicole A. Perry-Hauser (Perry). ISBN 978-3-319-57552-0
(2014) Microbial Indicators for Monitoring Pollution and Bioremediation Microbial Biodegradation and Bioremediation Nicole A. Perry-Hauser (Perry). ISBN 9780128000212 (doi: 10.1016/b978-0-12-800021-2.00005-4)
Professional activities & recognition
Prizes, awards & distinctions
- 2023: Vanderbilt School of Medicine (Discovery Science Emerging Scholar)
- 2023: University of Utah (Postdoc Rising Star, Neurobiology Session)
- 2023: Yale University (Intersections Science Fellows Symposium (ISFS) Associate)
- 2021: HHMI/Janelia Research Campus (Leading Edge Fellow)
- 2018: Vanderbilt School of Medicine (Inaugural Awardee of Dean’s Award for Exceptional Achievement)
- 2018: Vanderbilt School of Medicine (Lai Sulin Scholarship)
- 2017: Philanthropic Educational Organization (P.E.O.) (Scholar Award)
Research fellowships
- 2023 - 2025: Columbia University Institute for Developmental Sciences Award
- 2020 - 2023: Ruth L. Kirschstein National Research Service Award in Mood and Anxiety Disorders
- 2018 - 2019: American Heart Association One Year Fellowship
- 2016 - 2018: American Heart Association Predoctoral Fellowship
- 2015 - 2016: Ruth L. Kirschstein National Research Service Award Training in Pharmacological Sciences
Grant committees & research advisory boards
- 2024: Adhesion GPCR Consortium, Board
Professional & learned societies
- 2019: Board Member, Adhesion GPCR Consortium
- 2025: Member, British Pharmacological Society
- 2025: Member, British Biochemical Society
Selected international presentations
- 2024: Adhesion GPCR Workshop (Mexico City, Mexico)
- 2023: Gordon Research Conference in Molecular Pharmacology (Les Diablerets, Switzerland)
- 2022: Adhesion GPCR Workshop (Copenhagen, Denmark)